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Dr Marion Bonnet PhD
Cymrawd Ymchwil MRC
- BonnetM@caerdydd.ac.uk
- +44 29206 87302
- Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell 3F08, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Trosolwyg
Rwy'n Gymrawd Ymchwil MRC mewn Meddygaeth Foleciwlaidd a Cellog yn yr Adran Heintiau ac Imiwnedd yn yr Ysgol Meddygaeth. Mae fy labordy yn astudio rôl marwolaeth celloedd necrosis wedi'i raglennu, larymau ac imiwnedd cynhenid mewn croen a llid ar y cyd.
Cyhoeddiad
2021
- Chinnery, P. F. et al. 2021. Choosing drugs for UK COVID-19 treatment trials. Nature Reviews Drug Discovery (10.1038/d41573-021-00203-7)
- Kervevan, J. et al. 2021. Targeting human langerin promotes HIV-1 specific humoral immune responses. PLoS Pathogens 17(7), article number: e1009749. (10.1371/journal.ppat.1009749)
- Eugénio, M. S. et al. 2021. TRIM21, a new component of the TRAIL-induced endogenous necrosome complex. Frontiers in Molecular Biosciences 8, article number: 645134. (10.3389/fmolb.2021.645134)
2017
- Michel, L. et al. 2017. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signaling pathways. British Journal of Dermatology 177(5), pp. 1322-1336. (10.1111/bjd.15577)
- Delehouze, C. et al. 2017. 6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury. Scientific Reports 7, article number: 12931. (10.1038/s41598-017-12788-4)
- Le Cann, F. et al. 2017. Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. FEBS Journal 284(18), pp. 3050-3068. (10.1111/febs.14176)
2014
- Eguether, T. et al. 2014. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nature Communications 5, article number: 4585. (10.1038/ncomms5585)
2013
- Kumari, S. et al. 2013. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39(5), pp. 899-911. (10.1016/j.immuni.2013.10.009)
2011
- Wullaert, A., Bonnet, M. and Pasparakis, M. 2011. NF-kB in the regulation of epithelial homeostasis and inflammation.. Cell Research 21, pp. 146-158. (10.1038/cr.2010.175)
- Bonnet, M. C. et al. 2011. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35(4), pp. 572-582. (10.1016/j.immuni.2011.08.014)
2009
- Clerzius, G., Gelinas, J., Daher, A., Bonnet, M., Meurs, E. and Gatignol, A. 2009. ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.. Journal of Virology 83, pp. 10119-10128. (10.1128/JVI.02457-08)
2006
- Bonnet, M., Daurat, C., Ottone, C. and Meurs, E. F. 2006. The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex. Cellular Signalling 18(11), pp. 1865-1875. (10.1016/j.cellsig.2006.02.010)
- Puel, A. et al. 2006. The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation. American Journal of Human Genetics 78(4), pp. 691-701. (10.1086/501532)
2003
- Courtois, G. et al. 2003. A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. Journal of Clinical Investigation 112(7), pp. 1108-1115. (10.1172/JCI18714)
- Picard, C. et al. 2003. Pyogenic bacterial infections in humans with IRAK-4 deficiency.. Science 299(5615), pp. 2076-2079. (10.1126/science.1081902)
2002
- Wecker, K., Bonnet, M., Meurs, E. and Delepierre, M. 2002. The role of the phosphorus BI-BII transition in protein-DNA recognition: the NF-kappaB complex.. Nucleic Acids Research 30(20), pp. 4452-4459. (10.1093/nar/gkf559)
2000
- Bonnet, M., Weil, R., Dam, E., Hovanessian, A. and Meurs, E. 2000. PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.. Molecular and Cellular Biology 20(3), pp. 4532-4542. (10.1128/mcb.20.13.4532-4542.2000)
Erthyglau
- Chinnery, P. F. et al. 2021. Choosing drugs for UK COVID-19 treatment trials. Nature Reviews Drug Discovery (10.1038/d41573-021-00203-7)
- Kervevan, J. et al. 2021. Targeting human langerin promotes HIV-1 specific humoral immune responses. PLoS Pathogens 17(7), article number: e1009749. (10.1371/journal.ppat.1009749)
- Eugénio, M. S. et al. 2021. TRIM21, a new component of the TRAIL-induced endogenous necrosome complex. Frontiers in Molecular Biosciences 8, article number: 645134. (10.3389/fmolb.2021.645134)
- Michel, L. et al. 2017. Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signaling pathways. British Journal of Dermatology 177(5), pp. 1322-1336. (10.1111/bjd.15577)
- Delehouze, C. et al. 2017. 6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury. Scientific Reports 7, article number: 12931. (10.1038/s41598-017-12788-4)
- Le Cann, F. et al. 2017. Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. FEBS Journal 284(18), pp. 3050-3068. (10.1111/febs.14176)
- Eguether, T. et al. 2014. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nature Communications 5, article number: 4585. (10.1038/ncomms5585)
- Kumari, S. et al. 2013. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39(5), pp. 899-911. (10.1016/j.immuni.2013.10.009)
- Wullaert, A., Bonnet, M. and Pasparakis, M. 2011. NF-kB in the regulation of epithelial homeostasis and inflammation.. Cell Research 21, pp. 146-158. (10.1038/cr.2010.175)
- Bonnet, M. C. et al. 2011. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35(4), pp. 572-582. (10.1016/j.immuni.2011.08.014)
- Clerzius, G., Gelinas, J., Daher, A., Bonnet, M., Meurs, E. and Gatignol, A. 2009. ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.. Journal of Virology 83, pp. 10119-10128. (10.1128/JVI.02457-08)
- Bonnet, M., Daurat, C., Ottone, C. and Meurs, E. F. 2006. The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex. Cellular Signalling 18(11), pp. 1865-1875. (10.1016/j.cellsig.2006.02.010)
- Puel, A. et al. 2006. The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation. American Journal of Human Genetics 78(4), pp. 691-701. (10.1086/501532)
- Courtois, G. et al. 2003. A hypermorphic IκBα mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. Journal of Clinical Investigation 112(7), pp. 1108-1115. (10.1172/JCI18714)
- Picard, C. et al. 2003. Pyogenic bacterial infections in humans with IRAK-4 deficiency.. Science 299(5615), pp. 2076-2079. (10.1126/science.1081902)
- Wecker, K., Bonnet, M., Meurs, E. and Delepierre, M. 2002. The role of the phosphorus BI-BII transition in protein-DNA recognition: the NF-kappaB complex.. Nucleic Acids Research 30(20), pp. 4452-4459. (10.1093/nar/gkf559)
- Bonnet, M., Weil, R., Dam, E., Hovanessian, A. and Meurs, E. 2000. PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.. Molecular and Cellular Biology 20(3), pp. 4532-4542. (10.1128/mcb.20.13.4532-4542.2000)
Ymchwil
Mae ein labordy yn defnyddio modelau vivo ynghyd â samplau clinigol i ddehongli mecanweithiau moleciwlaidd croen a achosir gan farwolaeth celloedd a llid ar y cyd.
Necrosis wedi'i raglennu a larymau mewn llid
Ystyriwyd yn hir fel ffurf oddefol o farwolaeth celloedd, yn ddiweddar dangoswyd bod necrosis yn broses reoleiddiedig, wedi'i actifadu gan amrywiaeth o ysgogiadau mewndarddol neu alldarddol, Derbynyddion Marwolaeth o'r fath (DRs), ymyrryd (IFNs), neu Derbynnydd tebyg i Doll (TLRs). Mae marwolaeth Necrotig yn hynod o lidiol oherwydd rhyddhau moleciwlau mewngellog, o'r enw larymau neu Batrymau Moleciwlaidd Cysylltiedig â Pherygl (DAMPs). Necroptosis yw'r ffurf nodwedd orau o necrosis wedi'i raglennu a dangoswyd ei fod yn achosi llid mewn nifer o organau, yn enwedig mewn epithelia rhwystr (croen, colon, aren). Mae'n cael ei reoleiddio gan y cymhleth necrosome sy'n cynnwys kinases RIPK1 a RIPK3 a'u swbstrad, pseudo-kinase MLKL.
Gan ddefnyddio dulliau genetig ac mewn modelau vivo, nod ein gwaith yw egluro rôl necrosis a larymau wedi'u rhaglennu, yn ogystal â dehongli'r rheoliad moleciwlaidd o necrosis wedi'i raglennu mewn clefydau llidiol, mewn cydweithrediad â chlinigwyr, i nodi biofarcwyr cynnar a thargedau therapiwtig newydd ar gyfer meddygaeth wedi'i phersonoli.
Bywgraffiad
Anrhydeddau a dyfarniadau
- 2017: Grant Ymchwil Ymchwilwyr Newydd MRC
- 2014: Cadeirydd Ymchwil Rhagoriaeth (Co-I), Universite Europeenne de Bretagne
- 2012: Gwobr Sefydliad Ymchwil Croen Ewrop
Aelodaethau proffesiynol
- Cymdeithas Dermatoleg Ymchwiliol Prydain (BSID)
- Cymdeithas Ewropeaidd ar gyfer Ymchwil Dermatolegol (ESDR)
- Sefydliad Marwolaeth Celloedd Ewropeaidd (ECDO)
Safleoedd academaidd blaenorol
- Cadeirydd Ymchwil Rhagoriaeth (Co-I), Institut de Recherche Sante-Environnmenet-Travail IRSET), Universite Rennes-I (Rennes, Ffrainc)
- Uwch Wyddonydd, INSERM U976, Hopital St-Louis (Paris, Ffrainc)
- Cymrawd Ôl-ddoethurol, Prifysgol Cologne (Cologne, yr Almaen)
Pwyllgorau ac adolygu
- 2023: Pwyllgor EDHR DII
- 2022: Golygydd Gwadd a Golygydd Adolygu, Frontiers in Immunology
Meysydd goruchwyliaeth
Marwolaeth celloedd
Llid
Bioleg croen
Arthritis
Goruchwyliaeth gyfredol
Africa Fernandez Nasarre
Myfyriwr ymchwil
Prosiectau'r gorffennol
Patrymau moleciwlaidd sy'n gysylltiedig â difrod mewn llid croen sy'n dibynnu ar necroptosis.
Themâu ymchwil
Arbenigeddau
- Imiwnoleg enetig
- Bioleg foleciwlaidd
- Bioleg Celloedd
- Dermatoleg