Dr William Ford
Senior Lecturer
Trosolwyg
Cymwysterau
- BSc Anrh: Gwyddorau Biolegol Cymhwysol
- PhD: Ffarmacoleg Gardiofasgwlaidd
Aelod o Ddisgyblaeth Ymchwil Ffarmacoleg a Ffisioleg yr Ysgol
Cyhoeddiad
2023
- Alotaibi, M. M., Hughes, L. and Ford, W. R. 2023. Assessing inhaler techniques of asthma patients using aerosol inhalation monitors (aim): a cross-sectional study. Healthcare 11(8), article number: 1125. (10.3390/healthcare11081125)
2022
- Alotaibi, M. M., Hughes, L., Bowen, J. L. and Ford, W. R. 2022. Stakeholders' views about the management of stable chronic conditions in community pharmacies. Pharmacy 10(3), article number: 59. (10.3390/pharmacy10030059)
2021
- Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)
2020
- Adner, M. et al. 2020. Back to the future: re-establishing guinea pig in vivo asthma models. Clinical Science 134(11), pp. 1219-1242. (10.1042/CS20200394)
2017
- Lowe, A. P. P., Thomas, R. S., Nials, A. T., Kidd, E. J., Broadley, K. J. and Ford, W. R. 2017. Route of administration affects corticosteroid sensitivity of a combined ovalbumin and lipopolysaccharide model of asthma exacerbation in guinea-pigs. Journal of Pharmacology and Experimental Therapeutics 362(2), pp. 327-337. (10.1124/jpet.117.241927)
- Turner, D. L., Ford, W. R., Kidd, E. J., Broadley, K. J. and Powell, C. 2017. Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. European Journal of Pharmacology 801, pp. 79-85. (10.1016/j.ejphar.2017.03.004)
2016
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
2015
- Lowe, A. P. P., Thomas, R., Nials, A. T., Kidd, E., Broadley, K. and Ford, W. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Evans, R. L. et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407)
- Lowe, A., Broadley, K. J., Nials, A. T., Ford, W. R. and Kidd, E. J. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007)
2013
- Ford, W. R., Blair, A. E., Evans, R. L., John, E., Bugert, J. J., Broadley, K. J. and Kidd, E. J. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130)
- Broadley, K. J., Fehler, M., Ford, W. R. and Kidd, E. J. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034)
- Anwar, M. A., Ford, W. R., Herbert, A. A. and Broadley, K. J. 2013. Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed. Vascular Pharmacology 58(1-2), pp. 140-149., article number: 10.1016/j.vph.2012.10.007. (10.1016/j.vph.2012.10.007)
2012
- Evans, R. L., Nials, A. T., Knowles, R. G., Kidd, E. J., Ford, W. R. and Broadley, K. J. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004)
- Turner, D. L. et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)
- Anwar, M. A., Ford, W. R., Broadley, K. J. and Herbert, A. A. 2012. Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine. British Journal of Pharmacology 165(7), pp. 2191-2202. (10.1111/j.1476-5381.2011.01706.x)
2011
- Natividad, G. M., Broadley, K. J., Kariuki, B., Kidd, E. J., Ford, W. R. and Simons, C. 2011. Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. Journal of Ethnopharmacology 137(1), pp. 808-816. (10.1016/j.jep.2011.06.042)
2010
- Broadley, K. J., Blair, A. E., Kidd, E. J., Bugert, J. J. and Ford, W. R. 2010. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. Journal of Pharmacology and Experimental Therapeutics 335(3), pp. 681-692. (10.1124/jpet.110.171876)
- Fehler, M., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by beta-phenylethylamine. Naunyn Schmiedeburgs Archives of Pharmacology 382(4), pp. 385-398. (10.1007/s00210-010-0554-1)
- Turner, D. L., Ferrari, N., Ford, W. R., Kidd, E. J., Paquet, L., Renzi, P. and Broadley, K. J. 2010. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. European Journal of Pharmacology 641(2-3), pp. 213-219. (10.1016/j.ejphar.2010.05.025)
- Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulmonary Pharmacology and Therapeutics 23(4), pp. 300-307. (10.1016/j.pupt.2010.03.001)
- Aljayyoussi, G., Ford, W. R., McKeown, N. B. and Gumbleton, M. 2010. Differential transport of anionic PAMAM dendrimers across in vitro biological barriers [Abstract]. Drug Discovery Today 15(23-24), pp. 1114. (10.1016/j.drudis.2010.09.440)
2009
- Broadley, K. J. et al. 2009. Effects of dietary amines on the gut and its vasculature. British Journal of Nutrition 101(11), pp. 1645-1652. (10.1017/s0007114508123431)
2008
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6), pp. 589-597. (10.1007/s00210-008-0331-6)
- Fernandez-Rodriguez, S., Ford, W. R., Broadley, K. J. and Kidd, E. J. 2008. Establishing the phenotype in novel acute and chronic murine models of allergic asthma. International Immunopharmacology 8(5), pp. 756-763. (10.1016/j.intimp.2008.01.025)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Protective role of beta 2- and beta 3-adrenoceptors at reperfusion in isolated rat heart. Journal of Molecular and Cellular Cardiology 44(4), pp. 719-719. (10.1016/j.yjmcc.2008.02.020)
2007
- Penson, P. E., Ford, W. R. and Broadley, K. J. 2007. Vasopressors for cardiopulmonary resuscitation - Does pharmacological evidence support clinical practice?. Pharmacology and Therapeutics 115(1), pp. 37-55. (10.1016/j.pharmthera.2007.03.003)
2005
- Ford, W. R., Underdown, N. and Hiley, C. 2005. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. British Journal of Pharmacology 146(6), pp. 809-816. (10.1038/sj.bjp.0706391)
- Ford, W. R., Fletcher, A., Forhead, A. and Fowden, A. 2005. Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation. The Journal of Physiology 562(2), pp. 493-505. (10.1113/jphysiol.2004.074161)
2002
- Ford, W. R., Honan, S. A., White, R. and Hiley, C. R. 2002. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. British Journal of Pharmacology 135(5), pp. 1191-1198. (10.1038/sj.bjp.0704565)
2001
- White, R., Ho, W. V., Bottrill, F. E., Ford, W. R. and Hiley, C. R. 2001. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. British Journal of Pharmacology 134(4), pp. 921-929. (10.1038/sj.bjp.0704333)
Articles
- Alotaibi, M. M., Hughes, L. and Ford, W. R. 2023. Assessing inhaler techniques of asthma patients using aerosol inhalation monitors (aim): a cross-sectional study. Healthcare 11(8), article number: 1125. (10.3390/healthcare11081125)
- Alotaibi, M. M., Hughes, L., Bowen, J. L. and Ford, W. R. 2022. Stakeholders' views about the management of stable chronic conditions in community pharmacies. Pharmacy 10(3), article number: 59. (10.3390/pharmacy10030059)
- Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)
- Adner, M. et al. 2020. Back to the future: re-establishing guinea pig in vivo asthma models. Clinical Science 134(11), pp. 1219-1242. (10.1042/CS20200394)
- Lowe, A. P. P., Thomas, R. S., Nials, A. T., Kidd, E. J., Broadley, K. J. and Ford, W. R. 2017. Route of administration affects corticosteroid sensitivity of a combined ovalbumin and lipopolysaccharide model of asthma exacerbation in guinea-pigs. Journal of Pharmacology and Experimental Therapeutics 362(2), pp. 327-337. (10.1124/jpet.117.241927)
- Turner, D. L., Ford, W. R., Kidd, E. J., Broadley, K. J. and Powell, C. 2017. Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. European Journal of Pharmacology 801, pp. 79-85. (10.1016/j.ejphar.2017.03.004)
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
- Lowe, A. P. P., Thomas, R., Nials, A. T., Kidd, E., Broadley, K. and Ford, W. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Evans, R. L. et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407)
- Lowe, A., Broadley, K. J., Nials, A. T., Ford, W. R. and Kidd, E. J. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007)
- Ford, W. R., Blair, A. E., Evans, R. L., John, E., Bugert, J. J., Broadley, K. J. and Kidd, E. J. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130)
- Broadley, K. J., Fehler, M., Ford, W. R. and Kidd, E. J. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034)
- Anwar, M. A., Ford, W. R., Herbert, A. A. and Broadley, K. J. 2013. Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed. Vascular Pharmacology 58(1-2), pp. 140-149., article number: 10.1016/j.vph.2012.10.007. (10.1016/j.vph.2012.10.007)
- Evans, R. L., Nials, A. T., Knowles, R. G., Kidd, E. J., Ford, W. R. and Broadley, K. J. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004)
- Turner, D. L. et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)
- Anwar, M. A., Ford, W. R., Broadley, K. J. and Herbert, A. A. 2012. Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine. British Journal of Pharmacology 165(7), pp. 2191-2202. (10.1111/j.1476-5381.2011.01706.x)
- Natividad, G. M., Broadley, K. J., Kariuki, B., Kidd, E. J., Ford, W. R. and Simons, C. 2011. Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. Journal of Ethnopharmacology 137(1), pp. 808-816. (10.1016/j.jep.2011.06.042)
- Broadley, K. J., Blair, A. E., Kidd, E. J., Bugert, J. J. and Ford, W. R. 2010. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. Journal of Pharmacology and Experimental Therapeutics 335(3), pp. 681-692. (10.1124/jpet.110.171876)
- Fehler, M., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by beta-phenylethylamine. Naunyn Schmiedeburgs Archives of Pharmacology 382(4), pp. 385-398. (10.1007/s00210-010-0554-1)
- Turner, D. L., Ferrari, N., Ford, W. R., Kidd, E. J., Paquet, L., Renzi, P. and Broadley, K. J. 2010. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. European Journal of Pharmacology 641(2-3), pp. 213-219. (10.1016/j.ejphar.2010.05.025)
- Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulmonary Pharmacology and Therapeutics 23(4), pp. 300-307. (10.1016/j.pupt.2010.03.001)
- Aljayyoussi, G., Ford, W. R., McKeown, N. B. and Gumbleton, M. 2010. Differential transport of anionic PAMAM dendrimers across in vitro biological barriers [Abstract]. Drug Discovery Today 15(23-24), pp. 1114. (10.1016/j.drudis.2010.09.440)
- Broadley, K. J. et al. 2009. Effects of dietary amines on the gut and its vasculature. British Journal of Nutrition 101(11), pp. 1645-1652. (10.1017/s0007114508123431)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6), pp. 589-597. (10.1007/s00210-008-0331-6)
- Fernandez-Rodriguez, S., Ford, W. R., Broadley, K. J. and Kidd, E. J. 2008. Establishing the phenotype in novel acute and chronic murine models of allergic asthma. International Immunopharmacology 8(5), pp. 756-763. (10.1016/j.intimp.2008.01.025)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Protective role of beta 2- and beta 3-adrenoceptors at reperfusion in isolated rat heart. Journal of Molecular and Cellular Cardiology 44(4), pp. 719-719. (10.1016/j.yjmcc.2008.02.020)
- Penson, P. E., Ford, W. R. and Broadley, K. J. 2007. Vasopressors for cardiopulmonary resuscitation - Does pharmacological evidence support clinical practice?. Pharmacology and Therapeutics 115(1), pp. 37-55. (10.1016/j.pharmthera.2007.03.003)
- Ford, W. R., Underdown, N. and Hiley, C. 2005. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. British Journal of Pharmacology 146(6), pp. 809-816. (10.1038/sj.bjp.0706391)
- Ford, W. R., Fletcher, A., Forhead, A. and Fowden, A. 2005. Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation. The Journal of Physiology 562(2), pp. 493-505. (10.1113/jphysiol.2004.074161)
- Ford, W. R., Honan, S. A., White, R. and Hiley, C. R. 2002. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. British Journal of Pharmacology 135(5), pp. 1191-1198. (10.1038/sj.bjp.0704565)
- White, R., Ho, W. V., Bottrill, F. E., Ford, W. R. and Hiley, C. R. 2001. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. British Journal of Pharmacology 134(4), pp. 921-929. (10.1038/sj.bjp.0704333)
Ymchwil
Aelod o Ddisgyblaeth Ymchwil Ffarmacoleg a Ffisioleg yr Ysgol
Diddordebau ymchwil
Mae fy niddordebau ymchwil wedi'u gwasgaru ar draws tri phrif faes gydag llinynnau cyffredin yn plethu trwyddynt. Yn hanesyddol mae fy nghefndir wedi bod ym maes ffarmacoleg gardiofasgwlaidd ac yn fwy penodol mewn anafiadau isgemia-ad-adfer-llif-gwaed myocardaidd (myocardial ischaemia-reperfusion injury). Rwyf wedi astudio sut mae'r system rennin-angiotensin yn effeithio ar adferiad tymor byr a thymor hir wedi anaf isgemia-ac-adfer-llif-gwaed myocardaidd. Yn fwy diweddar, rwy'n ymwneud ag ymchwilio i ymatebion cardiofasgwlaidd i endocannabinoidau ac aminau hybrin. Rwyf hefyd yn ymwneud ag ymchwil ysgyfeiniol lle rydym yn astudio effeithiau addasu cydrannau o’r ymateb i’r llid (gan gynnwys defnyddio endocannabinoidau) i leihau llid a chaethni’r bronci a achosir gan alergenau. Mae astudio'r system endocannainoid hefyd yn sail i gydweithrediad newydd gyda Norgine i astudio clefyd llid y coluddyn.
Cannabinoidau yn y system gardiofasgwlaidd
Mae'r corff yn gallu cynhyrchu a rhyddhau cyfansoddion (endocannabinoidau) tebyg i'r rhai a geir mewn darnau o Ganabis sativa. Yr hyn mae gennym ddiddordeb ynddo yw darganfod pa dderbynyddion sy'n cysylltu'r endocannabinoidau hyn ag ymateb cardiofasgwlaidd. Drwy’n gwaith rydym wedi nodi ymatebion cardiofasgwlaidd yr ymddengys eu bod yn cael eu cyfryngu gan un neu ragor o safleoedd gweithredu newydd. Gan ein bod ni ac eraill wedi dangos bod endocannabinoidau yn cyfryngu ymatebion cardiofasgwlaidd pwysig, megis amddiffyn rhag anafiadau isgemia-ac-adfer-llif-gwaed, mae'r safleoedd gweithredu newydd hyn yn cynrychioli targedau therapiwtig posibl.
Cannabinoidau yn y llwybr gastroberfeddol
Mae arsylwadau yn ymwneud â defnyddwyr canabis yn awgrymu y gallai endocannabinoidau fod â rôl fuddiol i'w chwarae wrth drin clefyd llid y coluddyn (IBD). Ar hyn o bryd rydym yn ymchwilio i'r posibilrwydd o fanteisio ar y system endocannabinoid ar gyfer trin IBD mewn cydweithrediad â phartner diwydiannol.
Llid yr ysgyfaint
Mae llid ar yr ysgyfaint, sydd heb ei reoleiddio yn sail i glefydau’ ysgyfaint dynol megis asthma a chlefyd rhwystrol cronig yr ysgyfaint (COPD). Mae gennym fodelau o lid guinea-mochyn a achosir gan ovalbumin a llid yr ysgyfaint murine. Yn y ddau fodel hyn gall caethni’r bronci yn ei gyfnod cynnar a’r cyfnod ar ei ddiwedd o ganlyniad i anadlu alergennau gael eu gweld. Yn y mochyn-cwta, rydym hefyd wedi cynhyrchu model o lid yr ysgyfaint o ganlyniad i haint firaol PIV-3 a ffliw yn ogystal â gwaethygiad achosir gan feirws o ran asthma alergaidd (wedi achosi gan ovalbumin). Yn ogystal â nodi priodweddau’r modelau hyn ymhellach, mae gennym ddiddordeb yn effeithiau endocannabinoidau, bradykinin ac oaminau hybrin ar swyddogaeth yr ysgyfaint ac ar lid ar yr ysgyfaint.
ysgogiad β-adrenodderbynyddion ac anafiadau isgema-ac-adfer-llif-gwaed myocardaidd
Mae adrenalin wedi cael ei roi ers blynyddoedd lawer i geisio dadebru cleifion asystolig. Mae'r cyfiawnhad ffarmacolegol dros ymyriad o'r fath yn wan. Fodd bynnag, rydym wedi bod yn ymchwilio i'r potensial y gall actifadu un neu fwy o β-adrenodderbynyddion amddiffyn y galon rhag anaf isgema-ac-adfer-llif-gwaed. O bosibl, gallai'r ymchwil hon arwain at driniaeth ar gyfer anafiadau isgema-ac-adfer-llif-gwaed myocardaidd.
Cydweithredwyr
- Rwyf wedi cydweithio â Dr Joachim Bugert yn Adran Microbioleg Feddygol yr Ysgol Meddygaeth ym maes heintiau firaol y llwybrau anadlu. Mae gennym ddiddordeb arbennig mewn heintiau a achosir gan feirws y ffliw a feirws parainffliwensa math 3, gan gynnwys mecanweithiau llid yr ysgyfaint a'i effeithiau ar sut mae’r ysgyfaint yn gweithio.
- Mae Dr Tony Nials, GlaxoSmithKline, wedi cyd-oruchwylio pedwar myfyriwr PhD â'r Athro Broadley gyda chymorth y cwmni dros y 10 mlynedd diwethaf.
- Rydym yng nghamau olaf y broses o gyflwyno cynnig gyda Dr Audrey Long, gynaecolegydd ymgynghorol sy’n gweithio i Ymddiriedolaeth GIG Caerdydd a'r Fro, i astudio rôl canabinoidau mewndarddol mewn achosion o newidiadau a achosir gan feichiogrwydd i gylchrediad y gwaed.
- Rwyf wedi cydweithio â'r Athro Broadley a Dr Kidd (ymchwil i’r systemau ysgyfeiniol a chardiofasgwlaidd). Rwyf hefyd yn datblygu prosiectau cydweithredol gyda'r Athro Baxter (ymchwil i’r system gardiofasgwlaidd), sydd wedi ymuno â'r Ysgol yn ddiweddar, a Dr Mark Gumbleton (ymchwil i’r bibell gastroberfeddol)
Ôl-ddoethurol: Dr M Akhtar Anwar
Prif arbenigedd
- Calon Langendorff
- Swyddogaeth meinwe cyhyrau ynysedig y galon
- Astudiaeth in vivo o'r system gardiofasgwlaidd
- Mesur swyddogaeth yr ysgyfaint gan ddefnyddio plethysmograffeg
Cyllid ymchwil
- Ysgoloriaethau cydweithredol gan Gyngor Ymchwil Biodechnoleg a’r Gwyddorau Biolegol (2006-9) i astudio effeithiau sensiteiddio ofalbwmin cronig ar yr ysgyfaint gyda GlaxoSmithKline
- Ysgoloriaeth gan Sefydliad Prydeinig y Galon (2004-8) i astudio sut mae is-deipiau o β-adrenodderbynyddion yn cael effaith ar ddifrifoldeb anafiadau ischaemia-ad-ddarlifiad myocardiaidd, a grant prosiect (2002-5) i ymchwilio i sut y gallai canabinoidau mewndarddol leihau achosion o anaf ischemia-ad-ddarlifiad myocardiaidd
- Ymchwil contract ar gyfer Ferring Research i ymchwilio i gyfansoddion gwrthlidiol newydd mewn perthynas â llid ar y llwybr anadlu
- Ysgoloriaethau a noddir gan ddiwydiant gyda Topigen (2006-9) i ymchwilio i effeithiau cyfansoddion sy’n rhyddhau nitrig-ocsid ar lid ar y llwybr anadlu a Norgine (2008-2011) i astudio rôl bosibl canabinoidau mewndarddol mewn achosion o glefyd llidiol y coluddyn
Addysgu
- PH1122 Rôl y fferyllydd mewn ymarfer proffesiynol
- PH1124 Systemau cyrff dynol
- PH1125 Priodweddau cemegol a biolegol moleciwlau cyffuriau
- PH2112 Egwyddorion dylunio cyffuriau
- PH2113 Clefydau a chyffuriau I
- PH2203 Tueddiadau cyffuriau
- PH3110 Optimeiddio gofal fferyllol
- PH3113 Clefydau a chyffuriau II
- PH3202 Methodoleg ymchwil
- PH4116 Prosiect ysgoloriaeth neu ymchwil ym maes fferylliaeth
- PH4118 Gwyddorau Fferyllol, Ymarfer Fferyllol a’r Claf
Bywgraffiad
Proffil gyrfa
- 2002 - Darlithydd Prifysgol Caerdydd (Caerdydd, y DU) yn Ysgol Fferylliaeth Cymru. (dyrchafwyd yn Uwch-ddarlithydd yn 2010)
- 1998-2002 - Prifysgol Caergrawnt (Caergrawnt, y DU) Cymrodoriaeth yr Adran Ffarmacoleg. Apwyntiad pum mlynedd gyda grant gweithredu adrannol (£72,000 dros 5 mlynedd). Cyflog: £24,227
- 1996-1998 - Prifysgol Alberta (Edmonton, Canada): Cymrodoriaeth ôl-ddoethurol gyda Dr BI Jugdutt yn ymchwilio i ffarmacoleg angiotensin II mewn ailfodelu cnawdychiad ôl-fyocardiaidd, anaf isgemia-ac-adfer-llif gwaed a metaboledd is-haen ynni myocardiaidd.
- 1994-96 - Prifysgol Alberta (Edmonton, Canada): Cymrodoriaeth ôl-ddoethurol Ciba-Giegy gyda Dr AS Clanachan, Dr R Schulz a Dr GD Lopaschuk. Ymchwilio i dderbynnydd adenosin A1 a ffarmacoleg sianel KATPwrth amddiffyn y galon rhag anaf isgemia-ac-adfer-llif gwaed a metaboledd is-haen ynni myocardiaidd.
Gwasanaeth gwyddonol
- Prif Olygydd Autonomic and Autacoid Pharmacology
- Aelod o fwrdd golygyddol Autonomic and Autocoid Pharmacology
Anrhydeddau a dyfarniadau
Anrhydeddau a dyfarniadau
Gwobr Robert Beamish, Papur gorau 1998
Enillydd gwobr Robert Beamish am y papur 'Effect of the novel angiotensin II type 1 receptor antagonist L-158,809 on acute infarct expansion and acute anterior myocardial infarction in the dog' a gyhoeddwyd yn y Canadian Journal of Cardiology
Gwobr Cymrodoriaeth Sefydliad Calon a Strôc Canada (1997)
Aelodaethau proffesiynol
- Cymdeithas Ffarmacolegol Prydain
- Cymdeithas Ryngwladol Ymchwil y Galon
- Cymdeithas Brydeinig ar gyfer Ymchwil Cardiofasgwlaidd