Professor David Lloyd
Teacher: Diagnostic Radiography and Imaging
Studies in Professor David Lloyd's Laboratory include:
- Biological timekeeping especially in the range seconds to hours in living organisms
- Monitoring intracellular events by non-invasive methods such as mass spectrometry, fluorescence techniques and NMR
- Using these approaches to solve medical, environmental and industrial problems
- Microwave interactions with biological systems: separated electric and magnetic field effects, and putative non-thermal components.
- Biology of the flagellate fish parasite, Spironucleus vortens (with Professor Jo Cable, BIOSI)
- Newly-synthesised fluorophores and phosphors as biological optical imaging agents [with Dr Simon J. A. Pope, Dr Ian A. Fallis and Dr Angelo J. Amoroso (Chemistry), Dr Catrin F. Williams (Engineering and BIOSI), and Dr Anthony J. Hayes (BIOSI Confocal)]
- Biological effects of microwaves with Dr Catrin F. Williams (Engineering and BIOSI) and Professor Adrian Porch (Engineering)
- Coupling of oscillatory behaviour in yeasts by intracellular water dynamics with Dr Lars Folke Olsen and Professor Luis A. Bagatolli (University of Southern Denmark)
Work supported by
- EU Funding
- The Royal Society
- Ser Cymru
- US National Institute of Health on Aging, Baltimore, USA 2015 - present
- Keio University: Institute for Advanced Biosciences at Tsuruoka, Japan 2005
- Johns Hopkins Medical School, Molecular Cardiobiology, Baltimore, USA 2002 to present
- INTECH, Buenos Aires, Argentina 1998
- Sabbatical at University of New South Wales, Australia 1999
- National Institute for Biosciences/Human Technology, Tsukuba Science City, Japan 1997; 1998
- University of New South Wales, Sydney, Australia 1997
- University of Kebansang, Kuala Lumpur, Malaysia 1989
- TATA Institute for Fundamental Research, Bombay, India 1989; 1991; 1993; 1995; 1997; 1998 to present
- Harvard University, USA 1986
- ATOMKI, Debrecen, Hungary 1984
- INRA, Bordeaux, France 1984
- Soviet Academy of Science, Moscow, USSR 1979
- Moscow State University, USSR 1979
- University of Southern Denmark at Odense, Denmark 1978 to present
- Odense University, Denmark 1977; 1978; 1980; 1981; 1983; 1986; 1990; 1994; 1996
- Rockefeller University, USA 1978
- University of Pennsylvania, USA 1967; 1969; 1971; 1975; 1978; 1979
Industrial collaboration with more than 50 companies and institutes.
Professor Marc Roussel (on sabbatical leave from Lethbridge, Alberta) used membrane inlet mass spectrometry to reveal the strange attractor that underlies the respiratory dynamics of yeast in continuous culture. This required simultaneous monitoring of dissolved H2S, CO2 and O2; 40,000 points at 15s intervals were acquired in a 3 month continuous culture experiment. This is the first unequivocal demonstration of chaotic control in a biological system at whole cell level.
Dr Katey Lemar established mechanisms for the anti-candidal properties of selected garlic components, diallyldisulphide and allyl alcohol produce apoptotic cell death in this organism without being too toxic to humans. This affords a new way of tackling antibiotic resistance; there are no reported incidents of microorganisms becoming resistant to the garlic compounds.
Dr Catrin F. Williams with Neem Biotechnology (Dr David Williams, Dr Gareth Evans, Dr Robert Saunders and Dr MIchael Graz), Professor Jo Cable and Dr Michael P. Coogan studied the biochemistry and infectivity of the protozoan, Spironucleus vortens towards angelfish, especially sensitivity of the parasite to garlic comstituents.
With Professor Adrian Porch (Engineering), Catrin currently studies effects and their mechanisms of 2.45 GHz microwaves on the bioluminescence of the marine bacterium, Vibrio fischeri and on cultured normal and cancerous human cell lines.
Recent Former Associates
Dr Stefanie Scheerer and Dr Francisco Gomez have established a stable continuous culture of Photobacterium fisheri. This can be used as an on-line monitor for toxic compounds (e.g. biocides) in environmental samples including water supplies. Miniaturization will lead to the development of personal protection systems. Effects of microwaves were studied.
Dr Simon Cottrell showed that freeze dried garlic powder is toxic to MRSA, and that synergistic affects in combination with oxycillin may provide a new chemotherapeutic strategy.
Dr Victoria Gray has shown that the morphology of Salmonella typhimurium and poona species is continually dependent on the tyrosine content of the growth medium. Various sources of the peptone used in the complex diagnostic media may be quite unsuitable on account of their tyrosine deficiency. Aflagellate organisms, unrecognisable as the pathogen, result if the medium is unsuitable.
Dr Kristina Harris investigated the effects of difluoro methylornithine on the growth, structure and function of Trichomonas vaginalis. Defective hydrogenosemes are one consequence of this ornithine decarboxylase inhibitor.
Dr Jonathan Wood investigated the application of garlic as an antibacterial specifically against MRSA. Resolution of effects required separation of the main toxic constituents; synergy with penicillin derivatives was researched.
Dr Coralie Millet investigated protozoal fish parasites Hexamita and Spironucleus spp. Market for viticulture of aquarium fish is $7b/an. Pathogenicity and invasiveness; biodiversity was studied and compared with that of free living species.
- 2015 - present Collaboration with US National Institute of Health on Aging, Baltimore, USA
- 2008 - present Honorary Professor (Cardiff University)
- 2008 – 2017 H.C. Andersen Professor of Biochemistry and Molecular Biology, (University of Southern Denmark, Odense, Denmark)
- 2001 - present Collaboration with Department of Molecular Cardiobiology, Johns Hopkins Medical University, Baltimore, USA
- 1978 - 2008 Professor of Microbiology (Cardiff University)
- 2001 - 2009 (six 1 week visits) Johns Hopkins University, Baltimore, USA, Department of Molecular Cardiobiology
- 1999 (6 months) University of New South Wales, Australia, Department of Biochemistry
- 1998 - 2009 (4 visits) AIST, Tsukuba City and Keio University, Japan
- 1998 (3 months) Tata Institute of Fundamental Research, Mumbai, India, Department of Molecular Biology
- 1997 (3 months) University of New South Wales, Australia, Department of Biochemistry
- 1990 (4 months) Odense University (U.S. Denmark), Department of Biochemistry
- 1986 (2 months) Harvard University, Biolabs, USA
- 1985 (2 months) ATOMKI Debrecen, Hungary
- 1984 (1 month) INRA Bordeaux, France
- 1982 - 1987 Head of the Microbiology Department, University College Cardiff, University of Wales
- 1978 Personal Chair (University College of South Wales & Monmouthshire)
- 1976 - 1978 Reader (University College of South Wales & Monmouthshire)
- 1977 Guest Scientist (2 months) Rockefeller University, New York, USA
- 1976 Senior Lecturer (University College of South Wales & Monmouthshire)
- 1972 DSc (Sheffield)
- 1969 - 1976 Lecturer (University College of South Wales & Monmouthshire)
- 1968 - 1979 (4 visits Wellcome, Leverhulme & RS) University of Pennsylvania, USA
- 1967 University of Pennsylvania, Philadelphia, USA, Department of Biophysics
- 1967 - 1969 Research Assistant MRC Group (Microbial Structure & Function)
- 1964 - 1967 ICI Research Fellowship (University College of South Wales & Monmouthshire)
- 1964 PhD (Wales) (University College of South Wales & Monmouthshire)
- 1961 BSc (Biochemistry, 1st Class Hons) (Sheffield University)
Honours and awards
- Lifetime award: British Society of Protozoology
- Lifetime award: International Society of Protistology
- Fellow of the Learned Society of Wales
- 2008-present Honorary Professor, Cardiff University
- 2008-2017 H.C. Andersen Professor of Biochemistry and Molecular Biology, University of Southern Denmark, Odense
- 1978-2008 Professor of Microbiology, Cardiff University
- 1982-1987 Head of the Microbiology Department, University College Cardiff, University of Wales
- 1978 Personal Chair, University College Cardiff, University of Wales
- 1976 -1978 Reader, University College of South Wales & Monmouthshire
- 1977 Guest Scientist (2 months) Rockefeller University, New York
- 1976 Senior Lecturer, University College of South Wales & Monmouthshire
- 1969-1976 Lecturer, University College of South Wales & Monmouthshire
- 1967-1969 Research Assistant MRC Group (Microbial Structure & Function), University College of South Wales & Monmouthshire
- 1964-1967 ICI Research Fellowship, University College of South Wales & Monmouthshire