Artificial metalloenzymes for catalysing new-to-nature reactions
Cross-coupling reactions are a powerful class of chemical transformations that enable synthetic chemists to efficiently form carbon-carbon bonds. Despite their widespread use, most transformations require high temperatures, toxic solvents, and scarce metals. To overcome these limitations, we are developing artificial metalloenzymes (ArMs), which are enzymes that contain non-natural metals or metal cofactors. In this project we are creating ArMs, by combining thermostable protein scaffolds with 3d-transition-metal cofactors, to catalyse the Mizoroki-Heck cross-coupling reaction. We envisage our engineered Heckase could replace existing catalysts, contributing to biocompatible catalytic pathways and the green synthesis of complex molecules.
Honours and awards
BSc Biological Sciences: Biochemistry (Hons), The University of Edinburgh, 2017-2021
MSc Systems and Synthetic Biology, The University of Edinburgh, 2021-2022
Eurpean RosettaCon Leipzig 2023: "Protein design in the age of artificial intelligence" poster prize
- Biocatalysis and enzyme technology
- Protein design and engineering