Professor John Aggleton FRS, FMedSci, BA MA Cantab, DPhil Oxon

Professor

: Aggleton@cardiff.ac.uk
: +44 29208 74563
: Tower Building, 70 Park Place, Cardiff, CF10 3AT

My research concerns the neural basis of cognition (especially memory), using a variety of methodologies to understand the interactions between supporting brain networks.

I have been Professor of Cognitive Neuroscience in the School of Psychology since 1994 and my research examines the architecture of the brain and how various brain structures cooperate to support different forms of memory. This research is multidisciplinary, bringing together neuroanatomy, behavioural neuroscience, and neuropsychology, to help reveal and understand contrasting neural pathways for recognition memory and episodic memory. One specific focus has been on cortical – subcortical interactions that support spatial memory and attention in rodents.

I am a Fellow of the Academy of Medical Sciences (2002 -), the Learned Society of Wales (2011 -), and a Fellow of the Royal Society (2012 -).

I have published over 300 scientific papers, and am a former President of the European Brain and Behaviour Society (2004 -2006) and of the British Neuroscience Association (2015-2017).

Date
Type

2023

Mathiasen, M. L., Aggleton, J. P. and Witter, M. P. 2023. Projections of the insular cortex to orbitofrontal and medial prefrontal cortex. A tracing study in the rat. Frontiers in Neuroanatomy 17, article number: 1131167. (10.3389/fnana.2023.1131167)

2022

Yanakieva, S., Mathiasen, M. L., Amin, E., Nelson, A. J. D., O'Mara, S. M. and Aggleton, J. P. 2022. Collateral rostral thalamic projections to prelimbic, infralimbic, anterior cingulate and retrosplenial cortices in the rat brain. European Journal of Neuroscience 56(10), pp. 5869-5887. (10.1111/ejn.15819)
Aggleton, J. P., Nelson, A. J. D. and O'Mara, S. M. 2022. Time to retire the serial Papez circuit: Implications for space, memory, and attention. Neuroscience and Biobehavioral Reviews 140, article number: 104813. (10.1016/j.neubiorev.2022.104813)
Aggleton, J. P. and O’Mara, S. M. 2022. The anterior thalamic nuclei: core components of a tripartite episodic memory system. Nature Reviews Neuroscience 23, pp. 505-516. (10.1038/s41583-022-00591-8)
Berry, S. C., Lawrence, A. D., Lancaster, T. M., Casella, C., Aggleton, J. P. and Postans, M. 2022. Subiculum – BNST structural connectivity in humans and macaques. NeuroImage 253, article number: 119096. (10.1016/j.neuroimage.2022.119096)
Coad, B., Ghomroudi, P. A., Sims, R., Aggleton, J., Vann, S. D. and Metzler-Baddeley, C. 2022. Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults. Neurobiology of Aging 113, pp. 39-54. (10.1016/j.neurobiolaging.2022.02.004)

2021

Aggleton, J. P., Yanakieva, S., Sengpiel, F. and Nelson, A. J. 2021. The separate and combined properties of the granular (area 29) and dysgranular (area 30) retrosplenial cortex. Neurobiology of Learning and Memory 185, article number: 107516. (10.1016/j.nlm.2021.107516)
Lomi, E., Mathiasen, M. L., Cheng, H. Y., Zhang, N., Aggleton, J. P., Mitchell, A. S. and Jeffery, K. J. 2021. Evidence for two distinct thalamocortical circuits in retrosplenial cortex. Neurobiology of Learning and Memory 185, article number: 107525. (10.1016/j.nlm.2021.107525)
Coad, B. M., Ghomroudi, P. A., Sims, R., Aggleton, J. P., Vann, S. D. and Metzler-Baddeley, C. 2021. Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.11.12.468385
Mathiasen, M. L., Nelson, A. J., Amin, E., O’Mara, S. M. and Aggleton, J. P. 2021. A direct comparison of afferents to the rat anterior thalamic nuclei and nucleus reuniens: overlapping but different. eNeuro 8(5), article number: 103. (10.1523/ENEURO.0103-20.2021)
Frost, B. E., Martin, S. K., Cafalchio, M., Islam, M. N., Aggleton, J. P. and O'Mara, S. M. 2021. Anterior thalamic inputs are required for subiculum spatial coding, with associated consequences for hippocampal spatial memory. Journal of Neuroscience 41(30), pp. 6511-6525. (10.1523/JNEUROSCI.2868-20.2021)
Bubb, E. J., Aggleton, J. P., O'Mara, S. M. and Nelson, A. J. D. 2021. Chemogenetics reveal an anterior cingulate-thalamic pathway for attending to task-relevant information. Cerebral Cortex 31(4), pp. 2169-2186. (10.1093/cercor/bhaa353)

2020

Mathiasen, M. L., O'Mara, S. and Aggerton, J. P. 2020. The anterior thalamic nuclei and nucleus reuniens: So similar but so different. Neuroscience and Biobehavioral Reviews 119, pp. 268-280. (10.1016/j.neubiorev.2020.10.006)
O'Connor, D. B. et al. 2020. Research priorities for the COVID-19 pandemic and beyond: a call to action for psychological science. British Journal of Psychology 111(4), pp. 603-629., article number: e12468. (10.1111/bjop.12468)
Bubb, E. J., Nelson, A. J. D., Cozens, T. C. and Aggleton, J. P. 2020. Organisation of cingulum bundle fibres connecting the anterior thalamic nuclei with the rodent anterior cingulate and retrosplenial cortices. Brain and Neuroscience Advances 4, pp. 1-22. (10.1177/2398212820957160)
Nelson, A. J. D., Kinnavane, L., Amin, E., O’Mara, S. M. and Aggleton, J. P. 2020. Deconstructing the direct reciprocal hippocampal-anterior thalamic pathways for spatial learning. Journal of Neuroscience 40(36), pp. 6978-6990. (10.1523/JNEUROSCI.0874-20.2020)
Powell, A. et al. 2020. Stable encoding of visual cues in the mouse retrosplenial cortex. Cerebral Cortex 30(8), pp. 4424-4437. (10.1093/cercor/bhaa030)
Aggleton, J. and Nelson, A. 2020. Distributed interactive brain circuits for object-in-place memory: a place for time?. Brain and Neuroscience Advances 4, pp. 1-11. (10.1177/2398212820933471)
Postans, M. et al. 2020. Uncovering a role for the dorsal hippocampal commissure in recognition memory. Cerebral Cortex 30(3), pp. 1001-1015. (10.1093/cercor/bhz143)
Coad, B., Craig, E., Louch, R., Aggleton, J., Vann, S. and Metzler-Baddeley, C. 2020. Precommissural and postcommissural fornix microstructure in healthy aging and cognition. Brain and Neuroscience Advances 4, pp. 1-12. (10.1177/2398212819899316)
Mole, J. P., Fasano, F., Evans, J., Sims, R., Kidd, E., Aggleton, J. and Metzler-Baddeley, C. 2020. APOE-e4-related differences in left thalamic microstructure in cognitively healthy adults. Scientific Reports 10, article number: 19787. (10.1038/s41598-020-75992-9)

2019

Islam, M. N., Martin, S. K., Aggleton, J. P. and O'Mara, S. M. 2019. NeuroChaT: A toolbox to analyse the dynamics of neuronal encoding in freely-behaving rodents in vivo [version 1; peer review: awaiting peer review]. Wellcome Open Research 4, pp. -., article number: 196. (10.12688/wellcomeopenres.15533.1)
Mathiasen, M., Louch, R., Nelson, A., Dillingham, C. and Aggleton, J. P. 2019. Trajectory of hippocampal fibres to the contralateral anterior thalamus and mammillary bodies in rats, mice, and macaque monkeys. Brain and Neuroscience Advances 3, pp. 1-18. (10.1177/2398212819871205)
Mathiasen, M. L., Amin, E., Nelson, A. J. D., Dillingham, C. M., O'Mara, S. M. and Aggleton, J. P. 2019. Separate cortical and hippocampal cell populations target the rat nucleus reuniens and mammillary bodies. European Journal of Neuroscience 49(12), pp. 1649-1672. (10.1111/ejn.14341)
Matulewicz, P., Ulrich, K., Islam, M. N., Mathiasen, M. L., Aggleton, J. P. and O'Mara, S. M. 2019. Proximal perimeter encoding in the rat rostral thalamus. Scientific Reports 9(1), article number: 2865. (10.1038/s41598-019-39396-8)
Kinnavane, L., Amin, E., Aggleton, J. P. and Nelson, A. J. D. 2019. Do the rat anterior thalamic nuclei contribute to behavioural flexibility?. Behavioural Brain Research 359, pp. 536-549. (10.1016/j.bbr.2018.10.012)
Metzler-Baddeley, C. et al. 2019. Fornix white matter glia damage causes hippocampal gray matter damage during age-dependent limbic decline. Scientific Reports 9, article number: 1060. (10.1038/s41598-018-37658-5)
Hartopp, N., Wright, P., Ray, N., Evans, T., Metzler-Baddeley, C., Aggleton, J. and O'Sullivan, M. 2019. A key role for subiculum-fornix connectivity in recollection in older age. Frontiers in Systems Neuroscience 12, article number: 70. (10.3389/fnsys.2018.00070)
Dillingham, C. M. et al. 2019. The anatomical boundary of the rat claustrum. Frontiers in Neuroanatomy 13, article number: 53. (10.3389/fnana.2019.00053)

2018

Powell, A., Hindley, E., Nelson, A., Davies, M., Amin, E., Aggleton, J. and Vann, S. 2018. Lesions of retrosplenial cortex spare immediate-early gene activity in related limbic regions in the rat. Brain and Neuroscience Advances 2, pp. 1-15. (10.1177/2398212818811235)
Nelson, A., Powell, A., Kinnavane, L. and Aggleton, J. 2018. Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats. Behavioral Neuroscience 132(5), pp. 378-387. (10.1037/bne0000265)
Nelson, A., Hindley, E., Vann, S. and Aggleton, J. 2018. When is the rat retrosplenial cortex required for stimulus integration?. Behavioral Neuroscience 132(5), pp. 366-377. (10.1037/bne0000267)
Bubb, E., Metzler-Baddeley, C. and Aggleton, J. 2018. The cingulum bundle: anatomy, function, and dysfunction. Neuroscience and Biobehavioral Reviews 92, pp. 104-127. (10.1016/j.neubiorev.2018.05.008)
Aggleton, J. P. and Morris, R. G. M. 2018. Memory: looking back and looking forward. Brain and Neuroscience Advances 2, pp. 1-9. (10.1177/2398212818794830)
Kinnavane, L., Vann, S. D., Nelson, A. J. D., O'Mara, S. M. and Aggleton, J. P. 2018. Collateral projections innervate the mammillary bodies and retrosplenial cortex: A new category of hippocampal cells. eNeuro 5(1), article number: e0383-17.2018. (10.1523/ENEURO.0383-17.2018)

2017

Powell, A. L., Nelson, A., Hindley, E., Davies, M., Aggleton, J. P. and Vann, S. D. 2017. The rat retrosplenial cortex as a link for frontal functions: a lesion analysis. Behavioural Brain Research 335, pp. 88-102. (10.1016/j.bbr.2017.08.010)
Powell, A. L. et al. 2017. The retrosplenial cortex and object recency memory in the rat. European Journal of Neuroscience 45(11), pp. 1451-1464. (10.1111/ejn.13577)
Mathiasen, M. L., Dillingham, C. M., Kinnavane, L., Powell, A. L. and Aggleton, J. P. 2017. Asymmetric cross-hemispheric connections link the rat anterior thalamic nuclei with the cortex and hippocampal formation. Neuroscience 349, pp. 128-143. (10.1016/j.neuroscience.2017.02.026)
Kinnavane, L., Amin, E., Olarte-Sanchez, C. and Aggleton, J. 2017. Medial temporal pathways for contextual learning: Network c-fos mapping in rats with or without perirhinal cortex lesions. Brain and Neuroscience Advances 1, pp. 1-14. (10.1177/2398212817694167)
Bubb, E., Kinnavane, L. and Aggleton, J. P. 2017. Hippocampal - diencephalic - cingulate networks for memory and emotion: An anatomical guide. Brain and Neuroscience Advances (10.1177/2398212817723443)

2016

Christiansen, K., Metzler-Baddeley, C., Parker, G., Muhlert, N., Jones, D. K., Aggleton, J. P. and Vann, S. D. 2016. Topographic separation of fornical fibers associated with the anterior and posterior hippocampus in the human brain: an MRI-diffusion study. Brain and Behavior 7(1) (10.1002/brb3.604)
Kinnavane, L., Amin, E., Olarte-Sanchez, C. and Aggleton, J. P. 2016. Detecting and discriminating novel objects: the impact of perirhinal cortex disconnection on hippocampal activity patterns. Hippocampus 26(11), pp. 1393-1413. (10.1002/hipo.22615)
Nelson, A., Olarte-Sanchez, C., Amin, E. and Aggleton, J. P. 2016. Perirhinal cortex lesions that impair object recognition memory spare landmark discriminations. Behavioural Brain Research 313, pp. 255-259. (10.1016/j.bbr.2016.07.031)
Aggleton, J. P., Pralus, A., Nelson, A. J. D. and Hornberger, M. 2016. Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit. Brain 139(7), pp. 1877-1890. (10.1093/brain/aww083)
Christiansen, K., Aggleton, J. P., Parker, G. D., O'Sullivan, M. J., Vann, S. D. and Metzler-Baddeley, C. 2016. The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study. NeuroImage 130, pp. 35-47. (10.1016/j.neuroimage.2015.12.055)
Christiansen, K., Dillingham, C. M., Wright, N. F., Saunders, R. C., Vann, S. D. and Aggleton, J. P. 2016. Complementary subicular pathways to the anterior thalamic nuclei and mammillary bodies in the rat and macaque monkey brain. European Journal of Neuroscience 43(8), pp. 1044-1061. (10.1111/ejn.13208)

2015

Olarte-Sánchez, C. M., Amin, E., Clea Warburton, E. and Aggleton, J. P. 2015. Perirhinal cortex lesions impair tests of object recognition memory yet spare novelty detection. European Journal of Neuroscience 42(12), pp. 3117-3127. (10.1111/ejn.13106)
Aggleton, J. P., Wright, N. F., Rosene, D. L. and Saunders, R. C. 2015. Complementary patterns of direct amygdala and hippocampal projections to the macaque prefrontal cortex. Cerebral Cortex 25(11), pp. 4351-4373. (10.1093/cercor/bhv019)
Jankowski, M. M., Passecker, J., Islam, M. N., Vann, S., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. 2015. Evidence for spatially-responsive neurons in the rostral thalamus. Frontiers in Behavioral Neuroscience 9, article number: 256. (10.3389/fnbeh.2015.00256)
Dillingham, C. M., Erichsen, J. T., O'Mara, S. M., Aggleton, J. P. and Vann, S. D. 2015. Fornical and non-fornical projections from the rat hippocampal formation to the anterior thalamic nuclei. Hippocampus 25(9), pp. 977-992. (10.1002/hipo.22421)
Dillingham, C. M., Holmes, J. D., Wright, N. F., Erichsen, J. T., Aggleton, J. P. and Vann, S. D. 2015. Calcium-binding protein immunoreactivity in Gudden's tegmental nuclei and the hippocampal formation: differential co-localization in neurons projecting to the mammillary bodies. Frontiers in Neuroanatomy 9, article number: 103. (10.3389/fnana.2015.00103)
Aggleton, J. P. and Nelson, A. J. D. 2015. Why do lesions in the rodent anterior thalamic nuclei cause such severe spatial deficits?. Neuroscience & Biobehavioral Reviews 54, pp. 131-144. (10.1016/j.neubiorev.2014.08.013)
Albasser, M. M., Olarte-Sánchez, C. M., Amin, E., Brown, M. W., Kinnavane, L. and Aggleton, J. P. 2015. Perirhinal cortex lesions in rats: Novelty detection and sensitivity to interference. Behavioral Neuroscience 129(3), pp. 227-243. (10.1037/bne0000049)
Nelson, A. J. D., Powell, A., Holmes, J. D., Vann, S. D. and Aggleton, J. P. 2015. What does spatial alternation tell us about retrosplenial cortex function?. Frontiers in Behavioral Neuroscience 9, article number: 126. (10.3389/fnbeh.2015.00126)
Kinnavane, L., Albasser, M. M. and Aggleton, J. P. 2015. Advances in the behavioural testing and network imaging of rodent recognition memory. Behavioural Brain Research 285, pp. 67-78. (10.1016/j.bbr.2014.07.049)
Wright, N. F., Vann, S. D., Aggleton, J. P. and Nelson, A. J. D. 2015. A critical role for the anterior thalamus in directing attention to task-relevant stimuli. Journal of Neuroscience 35(14), pp. 5480-5488. (10.1523/JNEUROSCI.4945-14.2015)
Nelson, A. J. D., Hindley, E., Pearce, J. M., Vann, S. D. and Aggleton, J. P. 2015. The effect of retrosplenial cortex lesions in rats on incidental and active spatial learning. Frontiers in Behavioral Neuroscience 9, article number: 11. (10.3389/fnbeh.2015.00011)
Dumont, J. R., Amin, E., Wright, N. F., Dillingham, C. M. and Aggleton, J. P. 2015. The impact of fornix lesions in rats on spatial learning tasks sensitive to anterior thalamic and hippocampal damage. Behavioural Brain Research 278, pp. 360-374. (10.1016/j.bbr.2014.10.016)
Ray, N. J. et al. 2015. Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience 35(2), pp. 739-747. (10.1523/JNEUROSCI.3617-14.2015)
Aggleton, J. P. and Christiansen, K. 2015. The subiculum: the heart of the extended hippocampal system. In: Progress in Brain Research., Vol. 219. Elsevier, pp. 65-82., (10.1016/bs.pbr.2015.03.003)

2014

Kinnavane, L., Amin, E., Horner, M. and Aggleton, J. P. 2014. Mapping parahippocampal systems for recognition and recency memory in the absence of the rat hippocampus. European Journal of Neuroscience 40(12), pp. 3720-3734. (10.1111/ejn.12740)
Tsanov, M. et al. 2014. The irregular firing properties of thalamic head direction cells mediate turn-specific modulation of the directional tuning curve. Journal of Neurophysiology 112(9), pp. 2316-2331. (10.1152/jn.00583.2013)
Olarte-Sánchez, C. M., Kinnavane, L., Amin, E. and Aggleton, J. P. 2014. Contrasting networks for recognition memory and recency memory revealed by immediate-early gene imaging in the rat. Behavioral Neuroscience 128(4), pp. 504-522. (10.1037/a0037055)
Jankowski, M. M., Islam, M. N., Wright, N. F., Vann, S. D., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. 2014. Nucleus reuniens of the thalamus contains head direction cells. eLife 3, article number: e03075. (10.7554/eLife.03075)
Aggleton, J. P. 2014. Looking beyond the hippocampus: old and new neurological targets for understanding memory disorders. Proceedings of the Royal Society B: Biological Sciences 281(1786) (10.1098/rspb.2014.0565)
Hindley, E., Nelson, A. J. D., Aggleton, J. P. and Vann, S. D. 2014. The rat retrosplenial cortex is required when visual cues are used flexibly to determine location. Behavioural Brain Research 263, pp. 98-107. (10.1016/j.bbr.2014.01.028)
Dumont, J. R., Wright, N. F., Pearce, J. M. and Aggleton, J. P. 2014. The impact of anterior thalamic lesions on active and passive spatial learning in stimulus controlled environments: Geometric cues and pattern arrangement. Behavioral Neuroscience 128(2), pp. 161-177. (10.1037/a0036280)
Hindley, E. L., Nelson, A. J. D., Aggleton, J. P. and Vann, S. D. 2014. Dysgranular retrosplenial cortex lesions in rats disrupt cross-modal object recognition. Learning and Memory 21(3), pp. 171-179. (10.1101/lm.032516.113)
Nelson, A. J. D., Hindley, E. L., Haddon, J. E., Vann, S. D. and Aggleton, J. P. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21(2), pp. 90-97. (10.1101/lm.032136.113)
Dumont, J. R., Amin, E. and Aggleton, J. P. 2014. Selective importance of the rat anterior thalamic nuclei for configural learning involving distal spatial cues. European Journal of Neuroscience 39(2), pp. 241-256. (10.1111/ejn.12409)
Aggleton, J. P., Saunders, R. C., Wright, N. F. and Vann, S. D. 2014. The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys. European Journal of Neuroscience 39(1), pp. 107-123. (10.1111/ejn.12389)

2013

Albasser, M. M., Dumont, J. R., Amin, E., Holmes, J., Horne, M. R., Pearce, J. M. and Aggleton, J. P. 2013. Association rules for rat spatial learning: the importance of the hippocampus for binding item identity with item location. Hippocampus 23(12), pp. 1162-1178. (10.1002/hipo.22154)
Wright, N. F., Vann, S. D., Erichsen, J. T., O'Mara, S. M. and Aggleton, J. P. 2013. Segregation of parallel inputs to the anteromedial and anteroventral thalamic nuclei of the rat. Journal of Comparative Neurology 521(13), pp. 2966-2986. (10.1002/cne.23325)
Jankowski, M. M. et al. 2013. The anterior thalamus provides a subcortical circuit supporting memory and spatial navigation. Frontiers in Systems Neuroscience 7, article number: 45. (10.3389/fnsys.2013.00045)
Metzler-Baddeley, C., Baddeley, R. J., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. 2013. Individual differences in fornix microstructure and body mass index. PLoS ONE 8(3), article number: e59849. (10.1371/journal.pone.0059849)
Jones, D. K., Christiansen, K. Y., Chapman, R. J. and Aggleton, J. 2013. Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: Implications for europsychological investigations.. Neuropsychologia 51(1), pp. 67-78. (10.1016/j.neuropsychologia.2012.11.018)

2012

Metzler-Baddeley, C., Jones, D. K., Steventon, J., Westacott, L., Aggleton, J. P. and O'Sullivan, M. 2012. Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience 32(49), pp. 17612-17619. (10.1523/JNEUROSCI.3299-12.2012)
Metzler-Baddeley, C., Hunt, S., Jones, D. K., Leemans, A., Aggleton, J. P. and O'Sullivan, M. 2012. Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology 79(23), pp. 2233-2240. (10.1212/WNL.0b013e31827689e8)
Aggleton, J. P., Brown, M. W. and Albasser, M. M. 2012. Contrasting brain activity patterns for item recognition memory and associative recognition memory: Insights from immediate-early gene imaging. Neuropsychologia 50(13), pp. 3141-3155. (10.1016/j.neuropsychologia.2012.05.018)
Brown, M. W., Barker, G. R. I., Aggleton, J. P. and Warburton, E. C. 2012. What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory. Neuropsychologia 50(13), pp. 3122-3140. (10.1016/j.neuropsychologia.2012.07.034)
Albasser, M. M., Amin, E., Lin, T. E., Iordanova, M. D. and Aggleton, J. P. 2012. Evidence that the rat hippocampus has contrasting roles in object recognition memory and object recency memory. Behavioral Neuroscience 126(5), pp. 659-669. (10.1037/a0029754)
Aggleton, J. P., Wright, N. F., Vann, S. D. and Saunders, R. C. 2012. Medial temporal lobe projections to the retrosplenial cortex of the macaque monkey brain. Hippocampus 22(9), pp. 1883-1900. (10.1002/hipo.22024)
Aggleton, J. P. 2012. Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function. Neuroscience & Biobehavioral Reviews 36(7), pp. 1579-1596. (10.1016/j.neubiorev.2011.09.005)
Oitzl, M. S., Schwabe, L. and Aggleton, J. P. 2012. Memory formation: Its changing face [Editorial]. Neuroscience & Biobehavioral Reviews 36(7), pp. 1577-1578. (10.1016/j.neubiorev.2012.03.004)
Saunders, R. C., Vann, S. D. and Aggleton, J. P. 2012. Projections from Gudden's tegmental nuclei to the mammillary body region in the cynomolgus monkey (Macaca fascicularis). Journal of Comparative Neurology 520(6), pp. 1128-1145. (10.1002/cne.22740)

2011

Metzler-Baddeley, C., Jones, D. K., Belaroussi, B., Aggleton, J. P. and O'Sullivan, M. 2011. Frontotemporal connections in episodic memory and aging: A diffusion MRI tractography study. The Journal of Neuroscience 31(37), pp. 13236-13245. (10.1523/JNEUROSCI.2317-11.2011)
Vann, S. D., Erichsen, J. T., O'Mara, S. M. and Aggleton, J. P. 2011. Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function. Hippocampus 21(9), pp. 945-957. (10.1002/hipo.20796)
Tsanov, M., Chah, E., Vann, S. D., Reilly, R. B., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. 2011. Theta-modulated head direction cells in the rat anterior thalamus. The Journal of Neuroscience 31(26), pp. 9489-9502. (10.1523/JNEUROSCI.0353-11.2011)
Metzler-Baddeley, C., Jones, D. K., Aggleton, J. P. and O'Sullivan, M. 2011. The fornix in ageing and memory decline: a diffusion MRI tractography study. Journal of Neurology 258(S1), pp. 18-18. (10.1007/s00415-011-6026-9)
Aggleton, J. P., Amin, E., Jenkins, T. A., Pearce, J. M. and Ward-Robinson, J. 2011. Lesions in the anterior thalamic nuclei of rats do not disrupt acquisition of stimulus sequence learning. The Quarterly Journal of Experimental Psychology 64(1), pp. 65-73. (10.1080/17470218.2010.495407)
Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M. and Aggleton, J. P. 2011. Perirhinal cortex lesions uncover subsidiary systems in the rat for the detection of novel and familiar objects. European Journal of Neuroscience 34(2), pp. 331-342. (10.1111/j.1460-9568.2011.07755.x)
Albasser, M. M., Amin, E., Iordanova, M. D., Brown, M. W., Pearce, J. M. and Aggleton, J. P. 2011. Separate but interacting recognition memory systems for different senses: The role of the rat perirhinal cortex. Learning & Memory 18(7), pp. 435-443. (10.1101/lm.2132911)
Tsanov, M., Vann, S. D., Erichsen, J. T., Wright, N. F., Aggleton, J. P. and O'Mara, S. M. 2011. Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus. Hippocampus 21(1), pp. 1-8. (10.1002/hipo.20749)
Poirier, G. L., Amin, E., Good, M. A. and Aggleton, J. P. 2011. Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice. Neuroscience 174, pp. 71-83. (10.1016/j.neuroscience.2010.11.025)
Tsanov, M., Wright, N. F., Vann, S. D., Erichsen, J. T., Aggleton, J. P. and O'Mara, S. M. 2011. Hippocampal inputs mediate theta-related plasticity in anterior thalamus. Neuroscience 187, pp. 52-62. (10.1016/j.neuroscience.2011.03.055)
Tsanov, M. et al. 2011. Oscillatory entrainment of thalamic neurons by theta rhythm in freely moving rats. Journal of Neurophysiology 105(1), pp. 4-17. (10.1152/jn.00771.2010)
Tinsley, C. J., Fontaine-Palmer, N. S., Vincent, M., Endean, E. P. E., Aggleton, J. P., Brown, M. W. and Warburton, E. C. 2011. Differing time dependencies of object recognition memory impairments produced by nicotinic and muscarinic cholinergic antagonism in perirhinal cortex. Learning & Memory 18(7), pp. 484-492. (10.1101/lm.2274911)
Aggleton, J. P., Dumont, J. R. and Warburton, E. C. 2011. Unraveling the contributions of the diencephalon to recognition memory: A review. Learning & Memory 18(6), pp. 384-400. (10.1101/lm.1884611)

2010

Amin, E., Wright, N. F., Poirier, G. L., Thomas, K. L., Erichsen, J. T. and Aggleton, J. P. 2010. Selective lamina dysregulation in granular retrosplenial cortex (area 29) after anterior thalamic lesions: an in situ hybridization and trans-neuronal tracing study in rats. Neuroscience 169(3), pp. 1255-1267. (10.1016/j.neuroscience.2010.05.055)
Wright, N. F., Erichsen, J. T., Vann, S. D., O'Mara, S. M. and Aggleton, J. P. 2010. Parallel but separate inputs from limbic cortices to the mammillary bodies and anterior thalamic nuclei in the rat. The Journal of Comparative Neurology 518(12), pp. 2334-2354. (10.1002/cne.22336)
Aggleton, J. P., O'Mara, S. M., Vann, S. D., Wright, N. F., Tsanov, M. and Erichsen, J. T. 2010. Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions. European Journal of Neuroscience 31(12), pp. 2292-2307. (10.1111/j.1460-9568.2010.07251.x)
Albasser, M. M., Chapman, R. J., Amin, E., Iordanova, M. D., Vann, S. D. and Aggleton, J. P. 2010. New behavioral protocols to extend our knowledge of rodent object recognition memory. Learning & Memory 17(8), pp. 407-419. (10.1101/lm.1879610)
Aggleton, J. P. 2010. Understanding retrosplenial amnesia: Insights from animal studies. Neuropsychologia 48(8), pp. 2328-2338. (10.1016/j.neuropsychologia.2009.09.030)
Horne, M. R., Iordanova, M. D., Albasser, M. M., Aggleton, J. P., Honey, R. C. and Pearce, J. M. 2010. Lesions of the perirhinal cortex do not impair integration of visual and geometric information in rats. Behavioral Neuroscience 124(3), pp. 311-320. (10.1037/a0019287)
Brown, M. W., Warburton, E. C. and Aggleton, J. P. 2010. Recognition memory: Material, processes, and substrates. Hippocampus 20(11), pp. 1228-1244. (10.1002/hipo.20858)
Aggleton, J. P., Albasser, M. M., Aggleton, D. J., Poirier, G. L. and Pearce, J. M. 2010. Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition. Behavioral Neuroscience 124(1), pp. 55-68. (10.1037/a0018320)
Albasser, M. M., Poirier, G. L. and Aggleton, J. P. 2010. Qualitatively different modes of perirhinal–hippocampal engagement when rats explore novel vs. familiar objects as revealed by c-Fos imaging. European Journal of Neuroscience 31(1), pp. 134-147. (10.1111/j.1460-9568.2009.07042.x)
Pothuizen, H. H. J., Davies, M., Aggleton, J. P. and Vann, S. D. 2010. Effects of selective granular retrosplenial cortex lesions on spatial working memory in rats. Behavioural Brain Research 208(2), pp. 566-575. (10.1016/j.bbr.2010.01.001)

2009

Garden, D. L. F., Massey, P. . V., Caruana, D. A., Johnson, B., Warburton, E. C., Aggleton, J. P. and Bashir, Z. I. 2009. Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia. Brain 132(7), pp. 1847-1857. (10.1093/brain/awp090)
Denby, C. E., Vann, S. D., Tsivilis, D., Aggleton, J. P., Montaldi, D., Roberts, N. and Mayes, A. R. 2009. The frequency and extent of mammillary body atrophy associated with surgical removal of a colloid cyst. American Journal of Neuroradiology 30(4), pp. 736-743. (10.3174/ajnr.A1424)
Vann, S. D. et al. 2009. Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods. Proceedings of the National Academy of Sciences 106(13), pp. 5442-5447. (10.1073/pnas.0812097106)
Iordanova, M. D., Burnett, D. J., Aggleton, J. P., Good, M. A. and Honey, R. C. 2009. The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies. European Journal of Neuroscience 30(11), pp. 2177-2189. (10.1111/j.1460-9568.2009.07010.x)
Robinson, J., Sanderson, D. J., Aggleton, J. P. and Jenkins, T. A. 2009. Suppression to visual, auditory, and gustatory stimuli habituates normally in rats with excitotoxic lesions of the perirhinal cortex. Behavioral Neuroscience 123(6), pp. 1238-1250. (10.1037/a0017444)
Vann, S. D., Aggleton, J. P. and Maguire, E. A. 2009. What does the retrosplenial cortex do?. Nature Reviews Neuroscience 10(11), pp. 792-802. (10.1038/nrn2733)
Pothuizen, H. H. J., Davies, M., Albasser, M. M., Aggleton, J. P. and Vann, S. D. 2009. Granular and dysgranular retrosplenial cortices provide qualitatively different contributions to spatial working memory: evidence from immediate-early gene imaging in rats. European Journal of Neuroscience 30(5), pp. 877-888. (10.1111/j.1460-9568.2009.06881.x)
Aggleton, J. P., Poirier, G. L., Aggleton, H. S., Vann, S. D. and Pearce, J. M. 2009. Lesions of the fornix and anterior thalamic nuclei dissociate different aspects of hippocampal-dependent spatial learning: Implications for the neural basis of scene learning. Behavioral Neuroscience 123(3), pp. 504-519. (10.1037/a0015404)
Albasser, M. M., Davies, M., Futter, J. E. and Aggleton, J. P. 2009. Magnitude of the object recognition deficit associated with perirhinal cortex damage in rats: Effects of varying the lesion extent and the duration of the sample period. Behavioral Neuroscience 123(1), pp. 115-124. (10.1037/a0013829)
Poirier, G. L. and Aggleton, J. P. 2009. Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity. Neuroscience 160(2), pp. 452-469. (10.1016/j.neuroscience.2009.02.021)

2008

Tsivilis, D., Vann, S. D., Denby, C., Roberts, N., Mayes, A. R., Montaldi, D. and Aggleton, J. P. 2008. A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory. Nature Neuroscience 11(7), pp. 834-842. (10.1038/nn.2149)
Kyd, R. J., Pearce, J. M., Haselgrove, M., Amin, E. and Aggleton, J. P. 2008. The effects of hippocampal system lesions on a novel temporal discrimination task for rats. Behavioural Brain Research 187(1), pp. 159-171. (10.1016/j.bbr.2007.09.010)
Poirier, G. L., Amin, E. and Aggleton, J. P. 2008. Qualitatively different hippocampal subfield engagement emerges with mastery of a spatial memory task by rats. The Journal of Neuroscience 28(5), pp. 1034-1045. (10.1523/JNEUROSCI.4607-07.2008)
Aggleton, J. P. 2008. Understanding anterograde amnesia: Disconnections and hidden lesions. Quarterly Journal of Experimental Psychology 61(10), pp. 1441-1471. (10.1080/17470210802215335)
Pothuizen, H. H. J., Aggleton, J. P. and Vann, S. D. 2008. Do rats with retrosplenial cortex lesions lack direction?. European Journal Of Neuroscience 28(12), pp. 2486-2498. (10.1111/j.1460-9568.2008.06550.x)
Shires, K. L. and Aggleton, J. P. 2008. Mapping immediate-early gene activity in the rat after place learning in a water-maze: the importance of matched control conditions. European Journal Of Neuroscience 28(5), pp. 982-996. (10.1111/j.1460-9568.2008.06402.x)
Poirier, G. L., Shires, K. L., Sugden, D., Amin, E., Thomas, K. L., Carter, D. A. and Aggleton, J. P. 2008. Anterior thalamic lesions produce chronic and profuse transcriptional deregulation in retrosplenial cortex: A model of retrosplenial hypoactivity and covert pathology. Thalamus and Related Systems 4(1), pp. 59-77.
Denby, C., Vann, S. D., Tsivilis, D., Mayes, A., Montaldi, D. and Aggleton, J. P. 2008. Neuroimaging of the fornix: present and future. Neuroscience Imaging 2(3), pp. 135-148.
Denby, C. et al. 2008. MRI measurement of fornix pathology: evidence of extensive fornix damage following surgical removal of colloid cysts in the third ventricle. Neuroscience Imaging 2(3), pp. 109-125.
Aggleton, J. P., Saunders, R. C. and Vann, S. D. 2008. Using hippocampal amnesia to understand the neural basis of diencephalic amnesia. In: Dere, E. et al. eds. Handbook of Episodic Memory., Vol. 18. Amsterdam: Elsevier, pp. 503-519., (10.1016/S1569-7339(08)00227-0)

2002

Jenkins, T. A., Dias, R., Amin, E., Brown, M. W. and Aggleton, J. P. 2002. Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats. Journal of Neuroscience 22(12), pp. 5230-5238.
Baddeley, A., Aggleton, J. P. and Conway, M. A. eds. 2002. Episodic memory: new directions in research. Oxford: Oxford University Press.
Jenkins, T. A., Dias, R., Amin, E. and Aggleton, J. P. 2002. Changes in Fos expression in the rat brain after unilateral lesions of the anterior thalamic nuclei. European Journal of Neuroscience 16(8), pp. 1425-1432. (10.1046/j.1460-9568.2002.02211.x)
Commins, S., Aggleton, J. P. and O'Mara, S. M. 2002. Physiological evidence for a possible projection from dorsal subiculum to hippocampal area CA1. Experimental Brain Research 146(2), pp. 155-160. (10.1007/s00221-002-1158-x)
Friedman, D. P., Aggleton, J. P. and Saunders, R. C. 2002. Comparison of hippocampal, amygdala, and perirhinal projections to the nucleus accumbens: Combined anterograde and retrograde tracing study in the Macaque brain. The Journal of Comparative Neurology 450(4), pp. 345-365. (10.1002/cne.10336)
Machin, P., Vann, S. D., Muir, J. L. and Aggleton, J. P. 2002. Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition of performance of tests of allocentric spatial memory. Behavioral Neuroscience 116(2), pp. 232-240. (10.1037//0735-7044.116.2.232)
Vann, S. D. and Aggleton, J. P. 2002. Extensive cytotoxic lesions of the rat retrosplenial cortex revel consistent deficits on tasks that tax allocentric spatial memory. Behavioral Neuroscience 116(1), pp. 85-94. (10.1037//0735-7044.116.1.85)
Ward-Robinson, J., Wilton, L. A. K., Muir, J. L., Honey, R. C., Vann, S. D. and Aggleton, J. P. 2002. Sensory preconditioning in rats with lesions of the anterior thalamic nuclei: evidence for intact nonspatial 'relational' processing. Behavioural Brain Research 133(2), pp. 125-133. (10.1016/S0166-4328(01)00465-X)
Aggleton, J. P. and Brown, M. W. 2002. Integrating systems for event memory: testing the contribution of the fornix. In: Squire, L. R. and Schacter, D. L. eds. Neuropsychology of Memory (3rd ed.). New York: Guilford Press, pp. 377-394.
Aggleton, J. P. and Pearce, J. M. 2002. Neural systems underlying episodic memory: insights from animal research. In: Baddeley, A., Aggleton, J. P. and Conway, M. eds. Episodic Memory: New Directions in Research. Oxford: Oxford University Press, pp. 204-231., (10.1093/acprof:oso/9780198508809.003.0012)
Bussey, T. J. and Aggleton, J. P. 2002. The 'what' and 'where' of event memory: Independence and interactivity within the medial temporal lobe. In: Parker, A., Wilding, E. L. and Bussey, T. J. eds. The Cognitive Neuroscience of Memory: Encoding and Retrieval. Studies in Cognition Hove: Psychology Press, pp. 217-233.

2001

Warburton, E. C., Baird, A. L., Morgan, A., Muir, J. L. and Aggleton, J. P. 2001. The conjoint importance of the hippocampus and anterior thalamic nuclei for allocentric spatial learning: evidence from a disconnection study in the rat. Journal of Neuroscience 21(18), pp. 7323-7330.
Brown, M. W. and Aggleton, J. P. 2001. Recognition memory: what are the roles of the perirhinal cortex and hippocampus?. Nature Reviews Neuroscience 2(1), pp. 51-61. (10.1038/35049064)
Aggleton, J. P. and Pearce, J. M. 2001. Neural systems underlying episodic memory: insights from animal research. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 356(1413), pp. 1467-1482. (10.1098/rstb.2001.0946)
Gaffan, E. A., Bannerman, D. M., Warburton, E. C. and Aggleton, J. P. 2001. Rats' processing of visual scenes: effects of lesions to fornix, anterior thalamus, mamillary nuclei or the retrohippocampal region. Behavioural Brain Research 121(1-2), pp. 103-117. (10.1016/S0166-4328(00)00389-2)
Wan, H., Warburton, E. C., Kusmierek, P., Aggleton, J. P., Kowalska, D. M. and Brown, M. W. 2001. Fos imaging reveals differential neuronal activation of areas of rat temporal cortex by novel and familiar sounds. European Journal of Neuroscience 14(1), pp. 118-124. (10.1046/j.0953-816x.2001.01625.x)
Bussey, T. J., Dias, R., Amin, E., Muir, J. L. and Aggleton, J. P. 2001. Perirhinal cortex and place-object conditional learning in the rat. Behavioral Neuroscience 115(4), pp. 776-785. (10.1037/0735-7044.115.4.776)
Wilton, L. A. K., Baird, A. L., Muir, J. L. and Aggleton, J. P. 2001. Excitotoxic lesions of the rostral thalamic reticular nucleus do not affect the performance of spatial learning and memory tasks in the rat. Behavioural Brain Research 120(2), pp. 177-187. (10.1016/S0166-4328(00)00369-7)
Wilton, L. A. K., Baird, A. L., Muir, J. L., Honey, R. C. and Aggleton, J. P. 2001. Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats. Behavioral Neuroscience 115(4), pp. 861-869. (10.1037/0735-7044.115.4.861)
Cho, K., Aggleton, J. P., Brown, M. W. and Bashir, Z. I. 2001. An experimental test of the role of postsynaptic calcium levels in determining synaptic strength using perirhinal cortex of rat. Journal of Physiology 532(2), pp. 459-466. (10.1111/j.1469-7793.2001.0459f.x)

2000

Vann, S. D., Brown, M. W., Erichsen, J. T. and Aggleton, J. P. 2000. Using Fos imaging in the rat to reveal the anatomical extent of the disruptive effects of fornix lesions. Journal of Neuroscience 20(21), pp. 8144-8152.
Holdstock, J. S., Mayes, A. R., Cezayirli, E., Isaac, C. L., Aggleton, J. P. and Roberts, N. 2000. A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage. Neuropsychologia 38(4), pp. 410-425. (10.1016/S0028-3932(99)00099-8)
Vann, S. D., Brown, M. W., Erichsen, J. T. and Aggleton, J. P. 2000. Fos imaging reveals differential patterns of hippocampal and parahippocampal subfield activation in rats in response to different spatial memory tests. Journal of Neuroscience 20(7), pp. 2711-2718.
Cho, K., Kemp, N., Noel, J., Aggleton, J. P., Brown, M. W. and Bashir, Z. I. 2000. A new form of long-term depression in the perirhinal cortex. Nature Neuroscience 3(2), pp. 150-156. (10.1038/72093)
Aggleton, J. P. et al. 2000. Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix. Brain 123(4), pp. 800-815. (10.1093/brain/123.4.800)
Bussey, T. J., Dias, R., Redhead, E. S., Pearce, J. M., Muir, J. L. and Aggleton, J. P. 2000. Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions. Experimental Brain Research 134(4), pp. 506-519. (10.1007/s002210000481)
Vann, S. D., Brown, M. W. and Aggleton, J. P. 2000. Fos expression in the rostral thalamic nuclei and associated cortical regions in response to different spatial memory tests. Neuroscience 101(4), pp. 983-991. (10.1016/S0306-4522(00)00288-8)
Dias, R. and Aggleton, J. P. 2000. Effects of selective excitotoxic prefrontal lesions on acquisition of nonmatching- and matching-to-place in the T-maze in the rat: differential involvement of the prelimbic-infralimbic and anterior cingulate cortices in providing behavioural flexibility. European Journal of Neuroscience 12(12), pp. 4457-4466. (10.1046/j.0953-816X.2000.01323.x)
Bussey, T. J., Duck, J., Muir, J. L. and Aggleton, J. P. 2000. Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat. Behavioural Brain Research 111(1-2), pp. 187-202. (10.1016/S0166-4328(00)00155-8)
Warburton, E. C., Baird, A. L., Morgan, A., Muir, J. L. and Aggleton, J. P. 2000. Disconnecting hippocampal projections to the anterior thalamus produces deficits on tests of spatial memory in rats. European Journal of Neuroscience 12(5), pp. 1714-1726. (10.1046/j.1460-9568.2000.00039.x)
Banati, R. B., Goerres, G. W., Tjoa, C., Aggleton, J. P. and Grasby, P. 2000. The functional anatomy of visual-tactile integration in man: a study using positron emission tomography. Neuropsychologia 38(2), pp. 115-124. (10.1016/S0028-3932(99)00074-3)
Aggleton, J. P., Vann, S. D., Oswald, C. J. P. and Good, M. A. 2000. Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer. Hippocampus 10(4), pp. 466-474. (10.1002/1098-1063(2000)10:4<466::AID-HIPO13>3.0.CO;2-Y)
Aggleton, J. P. ed. 2000. The Amygdala: a functional analysis. Oxford: Oxford University Press.
Aggleton, J. P. and Saunders, J. P. 2000. The amygdala - what's happened in the last decade?. In: Aggleton, J. P. ed. The Amygdala: A Functional Analysis (2nd ed.). Oxford: Oxford University Press, pp. 1-30.
Barton, R. A. and Aggleton, J. P. 2000. Primate evolution and the amygdala. In: Aggleton, J. P. ed. The Amygdala: A Functional Analysis (2nd ed.). Oxford: Oxford University Press, pp. 479-508.
Aggleton, J. P. and Young, A. W. 2000. The enigma of the amygdala: Concerning its contribution to human emotion. In: Lane, R. D. and Nadel, L. eds. Cognitive Neuroscience of Emotion. Series in Affective Science Oxford: Oxford University Press, pp. 106-128.

1999

Aggleton, J. 1999. Mapping recognition memory in the primate brain: why it's sometimes right to be wrong. Brain Research Bulletin 50(5-6), pp. 447-448. (10.1016/S0361-9230(99)00127-6)
McCaffery, B. et al. 1999. Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro. Neuroscience 93(3), pp. 977-984. (10.1016/S0306-4522(99)00205-5)
Dix, S. L. and Aggleton, J. 1999. Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behavioural Brain Research 99(2), pp. 191-200. (10.1016/S0166-4328(98)00079-5)
Aggleton, J. P. and Waskett, L. 1999. The ability of odours to serve as state-dependent cues for real-world memories: Can Viking smells aid the recall of Viking experiences?. British Journal of Psychology 90(1), pp. 1-7. (10.1348/000712699161170)
Holdstock, J. S., Mayes, A., Cezayirli, E., Aggleton, J. and Roberts, N. 1999. A comparison of egocentric and allocentric spatial memory in medial temporal lobe and Korsakoff amnesics. Cortex 35(4), pp. 479-501. (10.1016/S0010-9452(08)70814-1)
Warburton, E. C., Morgan, A., Baird, A. L., Muir, J. L. and Aggleton, J. P. 1999. Does pretraining spare the spatial deficit associated with anterior thalamic damage in rats?. Behavioral Neuroscience 113(5), pp. 956. (10.1037//0735-7044.113.5.956)
Wan, H., Aggleton, J. P. and Brown, M. W. 1999. Different contributions of the hippocampus and perirhinal cortex to recognition memory. The Journal of Neuroscience 19(3), pp. 1142-1148.
Aggleton, J. P. and Brown, M. W. 1999. Thanks for the memories: Extending the hippocampal-diencephalic mnemonic system [Letter]. Behavioral and Brain Sciences 22(3), pp. 471-479. (10.1017/S0140525X99482032)
Aggleton, J. P. and Brown, M. W. 1999. Episodic memory, amnesia and the hippocampal - anterior thalamic axis. Behavioral and Brain Sciences 22(3), pp. 425-444.
Bussey, T. J., Muir, J. L. and Aggleton, J. P. 1999. Functionally dissociating aspects of event memory: The effects of combined perirhinal and postrhinal lesions on object and place memory in the rat. The Journal of Neuroscience 19(1), pp. 495-502.

1998

Warburton, E. and Aggleton, J. 1998. Differential deficits in the Morris water maze following cytotoxic lesions of the anterior thalamus and fornix transection. Behavioural Brain Research 98(1), pp. 27-38. (10.1016/S0166-4328(98)00047-3)
Hunt, P. R. and Aggleton, J. 1998. An examination of the spatial working memory deficit following neurotoxic medial dorsal thalamic lesions in rats. Behavioural Brain Research 97(1-2), pp. 129-141. (10.1016/S0166-4328(98)00033-3)
Warburton, E. C., Aggleton, J. P. and Muir, J. L. 1998. Comparing the effects of selective cingulate cortex and cingulum bundle lesions on a spatial navigation task. European Journal of Neuroscience 10(2), pp. 622-634. (10.1046/j.1460-9568.1998.00074.x)
Steckler, T., Sahgal, A., Aggleton, J. and Drinkenburg, W. H. I. M. 1998. Recognition memory in rats-III. Neurochemical substrates. Progress in Neurobiology 54(3), pp. 333-348. (10.1016/S0301-0082(97)00062-2)
Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A. and Aggleton, J. 1998. Recognition memory in rats-II. Neuroanatomical substrates. Progress in Neurobiology 54(3), pp. 313-332. (10.1016/S0301-0082(97)00061-0)
Steckler, T., Drinkenburg, W. H. I. M., Sahgal, A. and Aggleton, J. 1998. Recognition memory in rats-I. Concepts and classification. Progress in Neurobiology 54(3), pp. 289-311. (10.1016/S0301-0082(97)00060-9)
Hunt, P. R. and Aggleton, J. P. 1998. Neurotoxic lesions of the dorsomedial thalamus impair the acquisition but not the performance of delayed matching to place by rats: a deficit in shifting response rules. The Journal of Neuroscience 18(23), pp. 10045-10052.
Bussey, T. J., Warburton, E. C., Aggleton, J. P. and Muir, J. L. 1998. Fornix lesions can facilitate acquisition of the transverse patterning task: a challenge for "configural" theories of hippocampal function. The Journal of Neuroscience 18(4), pp. 1622-1631.
Reeve, D. K. and Aggleton, J. P. 1998. On the specificity of expert knowledge about a soap opera: an everyday story of farming folk. Applied Cognitive Psychology 12(1), pp. 35-42. (10.1002/%28SICI%291099-0720%28199802%2912:1%3C35::AID-ACP485%3E3.0.CO;2-2)

1997

Young, A. W. and Aggleton, J. P. 1997. Response from Young and Aggleton [reply to Daniel Tranel: Emotional processing and the human amygdala]. Trends in Cognitive Sciences 1(2), pp. 47-48. (10.1016/S1364-6613(97)01020-6)
Ennaceur, A. and Aggleton, J. 1997. The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behavioural Brain Research 88(2), pp. 181-193. (10.1016/S0166-4328(97)02297-3)
Warburton, E. C., Baird, A. and Aggleton, J. 1997. Assessing the magnitude of the allocentric spatial deficit associated with complete loss of the anterior thalamic nuclei in rats. Behavioural Brain Research 87(2), pp. 223-232. (10.1016/S0166-4328(97)02285-7)
Aggleton, J., Keen, S., Warburton, E. C. and Bussey, T. J. 1997. Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Research Bulletin 43(3), pp. 279-287. (10.1016/S0361-9230(97)00007-5)
Ennaceur, A., Aggleton, J. P. and Fray, P. J. 1997. Delayed non-matching to sample in a novel automated visual apparatus using mixed retention intervals. Neuroscience Research Communications 20(2), pp. 103-111. (10.1002/%28SICI%291520-6769%28199703%2920:2%3C103::AID-NRC191%3E3.0.CO;2-A)
Scott, S. K., Young, A. W., Calder, A. J., Hellawell, D. J., Aggleton, J. P. and Johnsons, M. 1997. Impaired auditory recognition of fear and anger following bilateral amygdala lesions [Letter]. Nature 385(6613), pp. 254-257. (10.1038/385254a0)
Zhu, X. O., McCabe, B. J., Aggleton, J. P. and Brown, M. W. 1997. Differential activation of the rat hippocampus and perirhinal cortex by novel visual stimuli and a novel environment. Neuroscience Letters 229(2), pp. 141-143. (10.1016/S0304-3940(97)00437-0)
Ennaceur, A., Neave, N. and Aggleton, J. P. 1997. Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Experimental Brain Research 113(3), pp. 509-519. (10.1007/PL00005603)
Good, J. M. M., Aggleton, J. P., Kentridge, R. W., Barker, J. G. M. and Neave, N. J. 1997. Measuring musical aptitude in children: on the role of age, handedness, scholastic achievement, and socioeconomic status. Psychology of Music 25(1), pp. 57-69. (10.1177/0305735697251005)
Neave, N., Nagle, S. and Aggleton, J. P. 1997. Evidence for the involvement of the mammillary bodies and cingulum bundle in allocentric spatial processing by rats. European Journal of Neuroscience 9(5), pp. 941-955. (10.1111/j.1460-9568.1997.tb01445.x)
Aggleton, J. P. and Saunders, R. C. 1997. The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia. Memory 5(1-2), pp. 49-72. (10.1080/741941143)
Bentivoglio, M., Aggleton, J. P. and Mishkin, M. 1997. The thalamus and memory formation. In: Steriade, M., Jones, E. G. and McCormick, D. A. eds. Thalamus. Amsterdam: Elsevier, pp. 689-720.

1996

Aggleton, J. P. and Shaw, C. 1996. Amnesia and recognition memory: a re-analysis of psychometric data. Neuropsychologia 34(1), pp. 51-62. (10.1016/0028-3932(95)00150-6)
Neave, N., Nagle, S., Sahgal, A. and Aggleton, J. P. 1996. The effects of discrete cingulum bundle lesions in the rat on the acquisition and performance of two tests of spatial working memory. Behavioural Brain Research 80(1-2), pp. 75-85. (10.1016/0166-4328(96)00022-8)
Ennaceur, A., Neave, N. and Aggleton, J. P. 1996. Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat. Behavioural Brain Research 80(1-2), pp. 9-25. (10.1016/0166-4328(96)00006-X)
Zhu, X. O., McCabe, B. J., Aggleton, J. P. and Brown, M. W. 1996. Mapping visual recognition memory through expression of the immediate early gene c-fos. NeuroReport 7(11), pp. 1871-1875.
Aggleton, J. P., Hunt, P. R., Nagle, S. and Neave, N. 1996. The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat. Behavioural Brain Research 80(1-2), pp. 75-85. (10.1016/S0166-4328(96)89080-2)
Aggleton, J. P. 1996. The ability of different strains of rats to acquire a visual nonmatching-to-sample task. Psychobiology 24, pp. 44-48.

1995

Holdstock, J., Shaw, C. and Aggleton, J. P. 1995. The performance of amnesic subjects on tests of delayed matching-to-sample and delayed matching-to-position. Neuropsychologia 33(12), pp. 1583-1596. (10.1016/0028-3932(95)00145-X)
Zhu, X. O., Brown, M. W., McCabe, B. J. and Aggleton, J. P. 1995. Effects of the novelty or familiarity of visual stimuli on the expression of the immediate early gene c-fos in rat brain. Neuroscience 69(3), pp. 821-829. (10.1016/0306-4522(95)00320-I)
Aggleton, J. P., Neave, N., Nagle, S. and Sahgal, A. 1995. A comparison of the effects of medial prefrontal, cingulate cortex, and cingulum bundle lesions on tests of spatial memory: evidence of a double dissociation between frontal and cingulum bundle contributions. The Journal of Neuroscience 15(11), pp. 7270-7281.
Aggleton, J. P., Neave, N., Nagle, S. and Hunt, P. R. 1995. A comparison of the effects of anterior thalamic, mamillary body and fornix lesions on reinforced spatial alternation. Behavioural Brain Research 68(1), pp. 91-101. (10.1016/0166-4328(94)00163-A)
Zhu, X. O., Brown, M. W. and Aggleton, J. P. 1995. Neuronal Signalling of Information Important to Visual Recognition-Memory in Rat Rhinal aid Neighbouring Cortices. European Journal of Neuroscience 7(4), pp. 753-765. (10.1111/j.1460-9568.1995.tb00679.x)
Shaw, C. and Aggleton, J. P. 1995. Evidence for the independence of recognition and recency memory in amnesic subjects. Cortex 31(1), pp. 57-71.
Young, A. W., Aggleton, J. P., Hellawell, D. J., Johnson, M., Broks, P. and Hanley, J. R. 1995. Face processing impairments after amygdalotomy. Brain 118(1), pp. 15-24. (10.1093/brain/118.1.15)

1994

Neave, N., Lloyd, S., Sahgal, A. and Aggleton, J. 1994. Lack of effect of lesions in the anterior cingulate cortex and retrosplenial cortex on certain tests of spatial memory in the rat. Behavioural Brain Research 65(1), pp. 89-101. (10.1016/0166-4328(94)90077-9)
Hunt, P., Neave, N., Shaw, C. and Aggleton, J. P. 1994. The effects of lesions to the fornix and dorsomedial thalamus on concurrent discrimination learning by rats. Behavioural Brain Research 62(2), pp. 195-205. (10.1016/0166-4328(94)90028-0)
Shaw, C. and Aggleton, J. P. 1994. The ability of amnesic subjects to estimate time intervals. Neuropsychologia 32(7), pp. 857-873. (10.1016/0028-3932(94)90023-X)

1993

Aggleton, J. P. and Sahgal, A. 1993. The contribution of the anterior thalamic nuclei to anterograde amnesia. Neuropsychologia 31(10), pp. 1001-1019. (10.1016/0028-3932(93)90029-Y)
Neave, N., Sahgal, A. and Aggleton, J. P. 1993. Lack of effect of dorsomedial thalamic lesions on automated tests of spatial memory in the rat. Behavioural Brain Research 55(1), pp. 39-49. (10.1016/0166-4328(93)90005-B)
Shaw, C. and Aggleton, J. P. 1993. The effects of fornix and medial prefrontal lesions on delayed non-matching-to-sample by rats. Behavioural Brain Research 54(1), pp. 91-102. (10.1016/0166-4328(93)90051-Q)

1991

Hunt, P. and Aggleton, J. P. 1991. Medial dorsal thalamic lesions and working memory in the rat. Behavioral and Neural Biology 55(2), pp. 227-246. (10.1016/0163-1047(91)80141-Z)

1990

Aggleton, J. P. and Mishkin, M. 1990. Visual impairments in macaques following inferior temporal lesions are exacerbated selectively by additional damage to superior temporal sulcus. Behavioural Brain Research 39(3), pp. 262-274. (10.1016/0166-4328(90)90032-A)
Shaw, C., Kentridge, R. W. and Aggleton, J. P. 1990. Cross-modal matching by amnesic subjects. Neuropsychologia 28(7), pp. 665-671. (10.1016/0028-3932(90)90121-4)

1986

Aggleton, J. P., Hunt, P. R. and Rawlins, J. N. P. 1986. The effects of hippocampal lesions upon spatial and non-spatial tests of working memory. Behavioural Brain Research 19(2), pp. 133-146. (10.1016/0166-4328(86)90011-2)

1985

Aggleton, J. P. 1985. X-ray localization of limbic structures in the cynomolgus monkey (Macaca fascicularis). Journal of Neuroscience Methods 14(2), pp. 101-108. (10.1016/0165-0270(85)90121-9)

1984

Aggleton, J. P. and Mishkin, M. 1984. Memory impairments following restricted thalamic lesions in monkeys [Abstract]. Behavioural Brain Research 12(2), pp. 165. (10.1016/0166-4328(84)90039-1)

1983

Aggleton, J. P. and Mishkin, M. 1983. Visual recognition impairment following medial thalamic lesions in monkeys. Neuropsychologia 21(3), pp. 189-197. (10.1016/0028-3932(83)90037-4)

Research topics and related papers

My research examines how different brain regions interact to support different forms of memory. The focus of this research has largely been on two distinct regions within the brain, the medial temporal lobe and the medial diencephalon. These questions are being pursued at a variety of levels; anatomical, behavioural and clinical. My anatomical studies examine the nature of the interactions between the temporal lobe and medial diencephalic structures, i.e. , their origin, the routes taken within the brain, and the degree to which single pathways link multiple regions (see below).

My behavioural studies examine animal models of amnesic conditions. For this reason, I am interested in refining learning tasks that tax the specific classes of cognitive problems found in amnesia. An important component has been the development of new tests of recognition memory, so enabling the study of the neural basis of recognition memory. I have proposed new models of how recognition memory and recall interact, and then tested these models with rodents and with clinical populations. My current focus is on the role of the anterior thalamic nuclei and how they interact with the hippocampus. This research, which is in close collaboration with researchers at Trinity College Dublin, is funded by a grant from the Wellcome Trust. In this way, I am trying to tease apart the functional contributions of a series of parallel temporal – medial diencephalic pathways that conjointly support memory.

A further part of my research involves collaborating on clinical studies of amnesia. In the past I have studied the effects on memory of surgeries to remove a colloid cyst in the third ventricle. These patients showed an informative distinction between recognition memory (spared) and recall (impaired). More recently I have collaborated with neuroimagers studying white matter to help identify how different brain pathways support different aspects of cognition.

Funding

2020-2023 - BBSRC Integrating and storing visuo-spatial cues in the retrosplenial cortex. With Frank Sengpiel (PI) and Seralynne Vann.

2016-2024 - Wellcome Trust PhD Programme in 'Integrative Neuroscience'. Lead Applicant and Director.

2014-2021 - Wellcome Trust Senior Investigator Award (with Shane O'Mara, TCD). The cognitive thalamus: More than a relay.

2015 - Welsh Government. Research Award 'Miniature microscopes to image neuronal ensembles in models of neuropsychiatric disorders' Co-applicant with R. Brambilla, S. Vann, V. Crunelli, M. Good, J. Hall, F. Sengpiel, K. Thomas.

Research group

Current researchers based in Cardiff University include: Dr Andrew Nelson, Dr Mathias Mathiasen, Ms Eman Amin, and Ms Steliana Yanakieva.

Research collaborators

UK based

Professor Zafir Bashir, Bristol University

Professor Clea Warburton Bristol University

Dr Seralynne Vann, Cardiff University

Dr Joseph O'Neill, Cardiff University

Dr Claudia Metzler-Baddeley, Cardiff University

Dr Michael Craig, Glasgow University

International

Professor Michael O'Sullivan, Perth Australia

Professor Shane O'Mara, Trinity College, Dublin

Undergraduate education

1965-72: Trinity School, Croydon 1973-6: B.A. University of Cambridge, Clare College; Natural Sciences

Postgraduate education

1980: D.Phil., Jesus College, University of Oxford, Thesis: Anatomical and Functional Subdivisions of the Amygdala. Supervisor: Dr. R.E. Passingham

Employment

1994-present: Professor of Cognitive Neuroscience, School of Psychology, University of Wales, Cardiff 1992-1994: Senior Lecturer, Department of Psychology, University of Durham 1983–1992: Lecturer, Department of Psychology, University of Durham 1980-1983: NIH Visiting Fellow, National Institute of Mental Health, Bethesda, Maryland. Laboratory of Neuropsychology (Head: Dr. M. Mishkin)

Honours and awards

Awards/external committees

Awards etc

2002: Fellow of the Academy of Medical Sciences (FMedSci)
2004-6: President of the European Brain and Behaviour Society
2006: Experimental Psychology Society – 4th Mid Career Award Prize
2007-9: Council Member, Academy of Medical Sciences
2009-2014: Royal Society Wolfson Research Merit Award
2011 - Fellow of the Learned Society of Wales
2012: Fellow of the Royal Society.
2015 - 2017 President of British Neuroscience Association
2009 Fellow of the Association of Psychological Science
2011 – Fellow of the Learned Society of Wales
2012 – Fellow of the Royal Society
2013 – Honorary Chair, Leicester University
2015 – 2017 President of the British Neuroscience Association

External Committees

Editorial Boards 1997-2000: European Journal of Neuroscience - Receiving Editor 1990-1993: Quarterly Journal of Experimental Psychology - Section B Associate Editor 1995-present: Brain Research Bulletin - Editorial Advisory Board 1995-present: Neuroscience and Biobehavioral Reviews - Editorial Advisory Board 1998-present: Behavioural Brain Research - Editorial Board 1998-present: Behavioral Neuroscience - Editorial Board 2000-present: European Journal of Neuroscience – Editorial Board 2001-present: Neuropsychologia –Board of Associate Editors

National Committees 1993-1995: MRC - NAHH (Neuroscience Approach to Human Health) Steering Committee 1996-2002: MRC - Neurosciences and Mental Health Studentships Allocation Panel 1997: MRC - Clinical Training and Career Development Panel 1997-2001: MRC - Neurosciences and Mental Health Board 1997-2002: MRC - Clinical Trials - Clinical Cross-Board subgroup 2003-2004: MRC – Cross Board 2008-present: MRC ad hoc committees

2004-2007: Wellcome Trust - Cognitive and Higher Systems Funding Committee 2004-2007: Wellcome Trust - Neuroscience and Mental Health (Joint) Committee 2007-present: Wellcome Trust - Chair of Cognitive and Higher Systems Funding Committee 2007-present: Wellcome Trust - Co Chair Neuroscience and Mental Health (Joint) Committee 2008-present: Wellcome Trust - Strategy Committee for Neuroscience and Mental Health 2009-present: British Neuroscience Association - Scientific Strategy Board

Wellcome Trust – Chair of Expert Review Group 3: Cognitive Neuroscience and Mental Health 2013 – 2017

Wellcome Trust - Interview Panels for grants/fellowships 2013, 2017, 2018

British Neuroscience Association, Scientific Strategy Board 2009 – 2014

British Neuroscience Association, Council member 2013 – 2019

Learned Society of Wales - Admissions Scrutiny Committee A1 2012 – 2014

Royal Society – Sectional Committee 8 2015 – 2018

Royal Society – Research System Community of Members 2019

Academy of Medical Sciences – Sectional Committee 2019 –

Royal Society & Wellcome Trust – Chair Sir Henry Dale Fellowship Committee 2020 -

International Committees

2004-2006: President of the European Brain and Behaviour Society 2002-2004: Council member of the European Brain and Behaviour Society 2004-2006: Council member of FENS (Federation of European Neuroscience Societies) 2008: Programme committee member for FENS (Geneva) 2007: International Jury for Inaugural Evens Scientific Research Challenge

2017 – 2019: Council member of FENS (Federation of European Neuroscience Societies)

Professional memberships

Learned Society of Wales

Royal Society

Academy Medical Sciences

European Brain and Behaviour Society

British Neuroscience Association

Experimental Psychology Society

Postgraduate research interests

There are currently two different, but related, programmes of research.

The first programme concerns temporal lobe structures and how they interact to support different forms of recognition memory. The principal area of interest concerns the behavioural analysis of recognition memory and other closely related forms of memory. Structural interactions are examined with a mixture of lesion, gene-expression and anatomical studies.

The second programme concerns the functions of structures in the diencephalon (thalamus and hypothalamus), and how these structures support memory. Here the focus is more on aspects of spatial memory. As part of this research, the significance of the links between the temporal lobe and diencephalon are also of especial interest.

If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.

Current students

Ms Julie Dumont