Dr David Harrison

2026

• Chibnall, A. et al. 2026. Sex-specific consequences of loss-of-imprinting of the maternally expressed gene Pleckstrin Homology-Like Domain Family A Member 2 (Phlda2) on placental development and fetal growth. Biology of Sex Differences (10.1186/s13293-026-00972-z)

2025

• Harrison, D. J. et al. 2025. Complex cognitive and motivational deficits precede motor dysfunction in the zQ175 (190 CAG repeat) Huntington's disease model.. Experimental Neurology 392 115350. (10.1016/j.expneurol.2025.115350)
• Paisey, S. J. et al. 2025. Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes. Neurobiology of Disease 209 106910. (10.1016/j.nbd.2025.106910)

2024

• Tyson, H. R. et al. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18 1374781. (10.3389/fnins.2024.1374781)

2022

• Lane, E. L. et al. 2022. Spontaneous graft-induced dyskinesias are independent of 5-HT neurons and levodopa priming in a model of Parkinson's disease. Movement Disorders 37 (3), pp.613-619. (10.1002/mds.28856)

2021

• Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30 (19), pp.1863-1880. ddab154. (10.1093/hmg/ddab154)

2020

• Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14 313. (10.3389/fnins.2020.00313)

2018

• Harrison, D. et al. 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27 (2), pp.230-244. (10.1177/0963689717744788)
• McNamara, G. I. et al. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27 (3), pp.440-450. (10.1093/hmg/ddx412)
• Harrison, D. J. 2018. Optimisation of transplantation methodology in mouse models of Huntington’s Disease. PhD Thesis , Cardiff University.

2017

• Hensman Moss, D. J. et al., 2017. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurology 16 (9), pp.701-711. (10.1016/S1474-4422(17)30161-8)
• Trueman, R. C. et al., 2017. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism 37 (4), pp.1349-1361. (10.1177/0271678X16654921)
• Ahmed, J. et al., 2017. Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism 37 (3), pp.755-761. (10.1177/0271678X16684141)

2016

• Bayram-Weston, Z. et al. 2016. Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease. Journal of Neuroscience Methods 265 , pp.81-88. (10.1016/j.jneumeth.2015.09.033)

2015

• Steventon, J. et al. 2015. In Vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's Disease mouse model. Journal of Huntington's Disease 4 (2), pp.149-160. (10.3233/JHD-150147)

2013

• Roberton, V. H. et al. 2013. Is the adult mouse striatum a hostile host for neural transplant survival?. NeuroReport 24 (18), pp.1010-1015. (10.1097/WNR.0000000000000066)
• Harrison, D. J. et al. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248 , pp.457-469. (10.1016/j.expneurol.2013.07.014)
• Lelos, M. J. et al. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71 , pp.287-294. (10.1016/j.appet.2013.09.003)

2012

• Lelos, M. J. , Harrison, D. J. and Dunnett, S. B. 2012. Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. European Journal of Neuroscience 36 (10), pp.3420-3428. (10.1111/j.1460-9568.2012.08256.x)

2011

• Lelos, M. J. , Harrison, D. J. and Dunnett, S. B. 2011. Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural Brain Research 225 (2), pp.522-528. (10.1016/j.bbr.2011.08.017)
• Trueman, R. C. et al. 2011. A critical re-Examination of the intraluminal filament MCAO model: impact of External Carotid Artery transection. Translational Stroke Research 2 (4), pp.651-661. (10.1007/s12975-011-0102-4)

2002

• Armit, C. et al., 2002. Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC Cell Biology 3 (27)(10.1186/1471-2121-3-27)
• Menke, A. et al., 2002. Genetic interactions between the Wilms’ Tumor 1 Gene and the p53 Gene. Cancer Research 62 (22), pp.6615-6620.
• Guo, J. et al., 2002. WT1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 11 (6), pp.651-659. (10.1093/hmg/11.6.651)