![Bruce Caterson](https://profiles-cardiff.imgix.net/attachments/651?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Bruce Caterson
Timau a rolau for Bruce Caterson
Athro Emeritws
Ysgol y Biowyddorau
Cyhoeddiad
2027
- Zhang, W. et al., 2027. Regulation of epithelial-mesenchymal cell-cell partners by complexes of paracrine signals and sulfated oligosaccharides. Biomaterials 336 124461. (10.1016/j.biomaterials.2026.124461)
2025
- Bondeson, J. et al. 2025. ADAMTS4. In: Rawlings, N. D. and Auld, D. S. eds. Handbook of Proteolytic Enzymes. 4th ed.. London: Academic Press. , pp.1263-1273. (10.1016/B978-0-443-28849-4.00196-X)
2020
- Nandadasa, S. et al., 2020. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. eLife 9 e60683. (10.7554/eLife.60683)
2018
- Tribble, J. R. et al. 2018. Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma. Molecular Brain 11 (1) 69. (10.1186/s13041-018-0412-5)
- Hayes, A. J. et al. 2018. Concise Review: Stem/progenitor cell proteoglycans decorated with 7-D-4, 4-C-3, and 3-B-3(-) chondroitin sulfate motifs are morphogenetic markers of tissue development. STEM CELLS 36 (10), pp.1475-1486. (10.1002/stem.2860)
- Caterson, B. and Melrose, J. 2018. Keratan sulfate, a complex glycosaminoglycan with unique functional capability. Glycobiology 28 (4), pp.182-206. (10.1093/glycob/cwy003)
- Littlechild, S. et al. 2018. Keratan sulfate phenotype in the β-1,3-N-acetylglucosaminyltransferase-7-null mouse cornea. Investigative Ophthalmology and Visual Science 59 , pp.1641-1651. (10.1167/iovs.17-22716)
- Hayes, A. et al. 2018. Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis. Biochemical Journal 475 (3), pp.587-620. (10.1042/BCJ20170820)
2017
- Powell, A. et al. 2017. Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?. Journal of Drug Targeting 25 (9-10), pp.919-926. (10.1080/1061186X.2017.1378660)
- Brown, S. et al., 2017. Contaminants in commercial preparations of 'purified' small leucine-rich proteoglycans may distort mechanistic studies. Bioscience Reports 37 (1) BSR20160465. (10.1042/BSR20160465)
2016
- Hayes, A. J. et al. 2016. The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow. Stem Cells and Development 25 (11), pp.836-847. (10.1089/scd.2016.0054)
- Farrugia, B. L. et al., 2016. Mast cells produce a unique chondroitin sulfate epitope. Journal of Histochemistry and Cytochemistry 64 (2), pp.85-98. (10.1369/0022155415620649)
- Bascoul-Colombo, C. et al., 2016. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1α in bovine cartilage explants. Cartilage 7 (1), pp.70-81. (10.1177/1947603515603762)
2015
- Yamada, K. et al., 2015. Mesenchymal-epithelial cell interactions and proteoglycan matrix composition in the presumptive stem cell niche of the rabbit corneal limbus. Molecular Vision 21 , pp.1328-1329.
- Roberts, S. et al., 2015. ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage 23 (9), pp.1622-1626. (10.1016/j.joca.2015.05.006)
- Beckett, M. C. et al., 2015. The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc. European Cells and Materials 30 , pp.69-88.
- Esa, A. et al. 2015. Investigating the role of Wnt antagonist protein Dkk-1 in the pathogenesis of osteoarthritis [Abstract]. International Journal of Experimental Pathology 96 (2), pp.A29-A29. (10.1111/iep.12125)
- Pantazopoulos, H. et al., 2015. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Translational Psychiatry 5 (1) e496. (10.1038/tp.2014.128)
- Chen, J. et al., 2015. Altered proteolytic activity and expression of mmps and aggrecanases and their inhibitors in Kashin-Beck disease. Journal of Orthopaedic Research 33 (1), pp.47-55. (10.1002/jor.22708)
- Fu, Q. et al., 2015. Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study. Osteoarthritis and Cartilage 23 (6), pp.868-873. (10.1016/j.joca.2015.01.009)
2014
- Turner, S. et al., 2014. Viability, growth kinetics and stem cell markers of single and clustered cells in human intervertebral discs: implications for regenerative therapies. European Spine Journal 23 (11), pp.2462-2472. (10.1007/s00586-014-3500-y)
- Li, S. et al., 2014. Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS ONE 9 (10) e109536. (10.1371/journal.pone.0109536)
- Ho, L. T. Y. et al. 2014. A comparison of glycosaminoglycan distributions, keratan sulphate sulphation patterns and collagen fibril architecture from central to peripheral regions of the bovine cornea. Matrix Biology 38 , pp.59-68. (10.1016/j.matbio.2014.06.004)
- Luo, M. et al., 2014. Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease. Osteoarthritis and Cartilage 22 (7), pp.986-995. (10.1016/j.joca.2014.05.012)
- Sivan, S. S. et al., 2014. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. European Spine Journal 23 (3), pp.344-353. (10.1007/s00586-013-2767-8)
- Smith, R. et al., 2014. Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal 46 (1), pp.4-9. (10.1111/evj.12128)
- Caterson, B. 2014. The effect of mycotoxins and selenium on the modification of cartilage proteoglycan sulphation. Presented at: 3rd International Conference on Selenium in the Environment and Human Health Hefei, China 10-14 November 2013. Published in: Banuelos, G. S. , Lin, Z. and Yin, X. eds. Selenium in the Environment and Human Health: Proceedings of the 3rd International Conference on Selenium in the Environment and Human Health. Boca Raton, Florida: CRC Press.
2013
- Lord, M. S. et al., 2013. Sulfation of the Bikunin Chondroitin Sulfate Chain Determines Heavy Chain·Hyaluronan Complex Formation. Journal of Biological Chemistry 288 (32), pp.22930-22941. (10.1074/jbc.M112.404186)
- Roberts, S. , Fuller, H. and Caterson, B. 2013. Contamination: Uphold standards for lab reagents [Letter]. Nature 496 (7445), pp.300. (10.1038/496300c)
- Bondeson, J. et al. 2013. ADAMTS4. In: Rawlings, N. D. and Salvesen, G. eds. Handbook of Proteolytic Enzymes. 3rd ed.. Vol. 1, London: Academic Press. , pp.1166-1173. (10.1016/B978-0-12-382219-2.00262-3)
- Bondeson, J. et al. 2013. ADAMTS5. In: Rawlings, N. D. and Salvesen, G. eds. Handbook of Proteolytic Enzymes. 3rd ed.. Vol. 1, London: Academic Press. , pp.1174-1180. (10.1016/B978-0-12-382219-2.00263-5)
- Coulson-Thomas, V. J. , Caterson, B. and Kao, W. W. 2013. Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of Mucopolysaccharidosis VII mice. Stem Cells 31 (10), pp.2116-2126. (10.1002/stem.1481)
- Guan, F. et al., 2013. Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions. Rheumatology International 33 (1), pp.157-166. (10.1007/s00296-011-2335-7)
- Hayes, A. J. et al. 2013. Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental Dynamics 242 (6), pp.778-789. (10.1002/dvdy.23970)
- Hayes, A. J. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8 (9), pp.e75787. (10.1371/journal.pone.0075787)
- Li, S. et al., 2013. The effect of beta-xylosides on the chondrogenic differentiation of mesenchymal stem cells. Histochemistry and Cell Biology 139 (1), pp.59-74. (10.1007/s00418-012-1017-1)
- Sheeran, L. et al. 2013. Classification-guided versus generalized postural intervention in subgroups of nonspecific chronic low back pain: a pragmatic randomized controlled study. Spine 38 (19), pp.1613-1625. (10.1097/BRS.0b013e31829e049b)
- Shu, C. et al., 2013. The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal 30 (7), pp.717-725. (10.1007/s10719-013-9475-9)
- Wainwright, S. D. et al. 2013. ADAMTS4_v1 is a splice variant of ADAMTS4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain. Arthritis & Rheumatism 65 (11), pp.2866-2875. (10.1002/art.38102)
2012
- Sheeran, L. et al. 2012. Spinal position sense and trunk muscle activity during sitting and standing in non-specific chronic low back pain: classification analysis. Spine 37 (8), pp.E486-E495. (10.1097/BRS.0b013e31823b00ce)
- Serpi, M. et al. 2012. Novel phosphoramidate prodrugs of N-Acetyl-(d)-Glucosamine with antidegenerative activity on bovine and human cartilage explants. Journal of Medicinal Chemistry 55 (10), pp.4629-4639. (10.1021/jm300074y)
- Bara, J. J. et al., 2012. Articular Cartilage Glycosaminoglycans Inhibit the Adhesion of Endothelial Cells. Connective Tissue Research 53 (3), pp.220-228. (10.3109/03008207.2011.629310)
- Brown, S. et al., 2012. A comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discs. European Spine Journal 21 (S2), pp.154-159. (10.1007/s00586-012-2179-1)
- Caterson, B. 2012. Fell-Muir Lecture: Chondroitin sulphate glycosaminoglycans: fun for some and confusion for others. International Journal of Experimental Pathology 93 (1), pp.1-10. (10.1111/j.1365-2613.2011.00807.x)
- Hatzirodos, N. et al., 2012. Glycomic analyses of ovarian follicles during development and atresia. Matrix Biology 31 (1), pp.45-56. (10.1016/j.matbio.2011.10.002)
- Li, S. et al., 2012. Proteoglycan metabolism, cell death and Kashin-Beck Disease. Glycoconjugate Journal 29 (5-6), pp.241-248. (10.1007/s10719-012-9421-2)
- Lu, M. et al., 2012. The Effects of Mycotoxins and Selenium Deficiency on Tissue-Engineered Cartilage. Cells Tissues Organs 196 (3), pp.241-250. (10.1159/000335046)
- Melrose, J. et al., 2012. Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology 138 (3), pp.461-475. (10.1007/s00418-012-0968-6)
- Phitak, T. et al., 2012. Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry 80 , pp.77-88. (10.1016/j.phytochem.2012.05.016)
- Schwend, T. et al., 2012. Corneal sulfated glycosaminoglycans and their effects on trigeminal nerve growth cone behavior in vitro: roles for ECM in cornea innervation. Investigative Ophthalmology and Visual Science 53 (13), pp.8118-8137. (10.1167/iovs.12-10832)
- Taylor, D. W. et al., 2012. Hyaline cartilage tissue is formed through the co-culture of passaged human chondrocytes and primary bovine chondrocytes. Journal of Histochemistry & Cytochemistry 60 (8), pp.576-587. (10.1369/0022155412449018)
- Wainwright, S. D. et al. 2012. Human osteoarthritis synovium contains an alternatively spliced transcript of ADAMTS4 [Abstract]. Osteoarthritis and Cartilage 20 (S1), pp.S136. (10.1016/j.joca.2012.02.185)
2011
- Akhtar, S. et al., 2011. Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 249 (3), pp.413-420. (10.1007/s00417-010-1512-9)
- Hayes, A. J. et al. 2011. Chondroitin sulphate sulphation motif expression in the ontogeny of the intervertebral disc. European Cells and Materials 21 , pp.1-14.
- Hayes, A. J. et al. 2011. Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc. European Cells and Materials 22 , pp.226-241.
2010
- Bondeson, J. et al. 2010. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis & Rheumatism 62 (3), pp.647-657. (10.1002/art.27290)
- Liles, M. et al., 2010. Differential relative sulfation of keratan sulfate glycosaminoglycan in the chick cornea during embryonic development. Investigative Ophthalmology and Visual Science 51 (3), pp.1365-1372. (10.1167/iovs.09-4004)
- Caterson, B. et al. 2010. Method for decreasing cartilage damage in dogs. US20100261793A1[Patent]
- Gabriel, N. et al., 2010. Development of an in vitro model of feline cartilage degradation. Journal of Feline Medicine & Surgery 12 (8), pp.614-620. (10.1016/j.jfms.2010.03.007)
- Hurst, S. et al., 2010. Dietary fatty acids and arthritis. Prostaglandins Leukotrienes & Essential Fatty Acids 82 (4-6), pp.315-318. (10.1016/j.plefa.2010.02.008)
- Ralphs, J. R. et al. 2010. Chondroitin sulphate sulfation motifs in intervertebral disc development [Abstract]. European Cells and Materials 20 (Supp 2), pp.3.
- Yang, B. et al., 2010. In vitrocartilage tissue engineering using cancellous bone matrix gelatin as a biodegradable scaffold. Biomedical Materials 5 (4) 045003. (10.1088/1748-6041/5/4/045003)
- Zhang, A. et al., 2010. Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease. Journal of Zhejiang University-Science B 11 (3), pp.200-208. (10.1631/jzus.B0900074)
2009
- Clarkin, C. E. et al., 2009. Phenotypic plasticity of superficial zone chondrocytes is revealed by increased glycosaminoglycan release and a unique angiogenic secretory profile from neo-cartilage grafts [Abstract]. International Journal of Experimental Pathology 90 (2), pp.A103-A104. (10.1111/j.1365-2613.2009.00644.x)
- Gealy, E. C. et al. 2009. Actin and type I collagen propeptide distribution in the developing chick cornea. Investigative Ophthalmology & Visual Science 50 (4), pp.1653 -1658. (10.1167/iovs.08-2554)
- Hurst, S. et al., 2009. Contrasting Effects of n-3 and n-6 Fatty Acids on Cyclooxygenase-2 in Model Systems for Arthritis. Lipids 44. (10), pp.889-896. (10.1007/s11745-009-3347-x)
- Rees, S. G. , Dent, C. M. and Caterson, B. 2009. Metabolism of proteoglycans in tendon. Scandinavian Journal of Medicine & Science in Sports 19 (4), pp.470-478. (10.1111/j.1600-0838.2009.00938.x)
- Rees, S. G. et al., 2009. Immunolocalisation and expression of keratocan in tendon. Osteoarthritis and Cartilage 17 (2), pp.276-279. (10.1016/j.joca.2008.07.007)
- Roberts, H. C. et al. 2009. Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation. International Journal of Experimental Pathology 90 (1), pp.A78-A79.
- Roberts, H. C. et al. 2009. Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation [Abstract]. International Journal of Experimental Pathology 90 (1), pp.A78-A79. (10.1111/j.1365-2613.2008.00612.x)
- Zainal, Z. et al., 2009. Modification of Palm Oil for Anti-Inflammatory Nutraceutical Properties. Lipids 44 (7), pp.581-592. (10.1007/s11745-009-3304-8)
- Zainal, Z. et al., 2009. Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis and Cartilage 17 (7), pp.896-905. (10.1016/j.joca.2008.12.009)
2008
- Akhtar, S. et al., 2008. Immunochemical localisation of keratan sulphate proteoglycans in cornea, sclera and limbus using a keratanase generated neoepitope monoclonal antibody. Investigative Ophthalmology and Visual Science 49 (6), pp.2424-2431. (10.1167/iovs.06-1498)
- Bondeson, J. et al. 2008. The regulation of ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review. Clinical and Experimental Rheumatology 26 (1), pp.139-145.
- Cao, J. et al., 2008. Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China. Osteoarthritis and Cartilage 16 (6), pp.680-8. (10.1016/j.joca.2007.09.002)
- Caterson, B. et al. 2008. Chondroitin sulphate motifs as biomarkers for the stem/progenitor cell niche in musculoskeletal tissues. European Cells and Materials 16 (Supp 2), pp.47-47.
- Davies, L. C. et al., 2008. The potential of IGF-1 and TGFβ1 for promoting “adult” articular cartilage repair: An in vitro study. Tissue Engineering Part A 14 (7), pp.1251-1261. (10.1089/ten.tea.2007.0211)
- Davies, L. C. et al. 2008. Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes. Osteoarthritis and Cartilage 16 (8), pp.855-864. (10.1016/j.joca.2007.12.005)
- Hayes, A. J. , Hughes, C. E. and Caterson, B. 2008. Antibodies and immunohistochemistry in extracellular matrix research. Methods 45 (1), pp.10-21. (10.1016/j.ymeth.2008.01.011)
- Hayes, A. J. et al. 2008. Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry & Cytochemistry 56 (2), pp.125-38. (10.1369/jhc.7A7320.2007)
- Khan, I. M. et al. 2008. Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage. Osteoarthritis and Cartilage 16 (6), pp.698-707. (10.1016/j.joca.2007.10.004)
- Li, S. et al., 2008. Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. Journal of Zhejiang University-Science B 9 (1), pp.22-33. (10.1631/jzus.B071322)
- McGuigan, C. et al. 2008. Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery. Journal of Medicinal Chemistry 51 (18), pp.5807-5812. (10.1021/jm800594c)
- Melrose, J. et al., 2008. Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research & Therapy 10 (4) R79. (10.1186/ar2453)
2007
- Young, R. D. et al. 2007. Keratan sulfate glycosaminoglycan and the association with collagen fibrils in rudimentary lamellae in the developing avian cornea. Investigative Ophthalmology and Visual Science 48 (7), pp.3083-3088. (10.1167/iovs.06-1323)
- Rees, S. G. et al., 2007. Inhibition of aggrecan turnover in short-term explant cultures of bovine tendon. Matrix Biology 26 (4), pp.280-290. (10.1016/j.matbio.2007.01.003)
- Bondeson, J. et al. 2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. The Journal of Rheumatology 34 (3), pp.523-533.
- Fang, S. C. et al., 2007. Fracture healing and its potential as a bioreactor for skeletal tissue engineering. European Cells and Materials 13 (Supp 2), pp.28-29.
- Gealy, E. C. et al. 2007. Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis. Histochemistry and Cell Biology 128 (6), pp.551-555. (10.1007/s00418-007-0332-4)
- Gendron, C. et al., 2007. Proteolytic activities of human ADAMTS-5: Comparative studies wth ADAMTS - 4. Journal of Biological Chemistry 282 (25), pp.18294-18306. (10.1074/jbc.M701523200)
- Hayes, A. J. et al. 2007. Macromolecular organization and in vitro growth characteristics of scaffold-free neocartilage grafts. Journal of Histochemistry & Cytochemistry 55 (8), pp.853-866. (10.1369/jhc.7A7210.2007)
- Jones, A. R. et al., 2007. Binding and localization of recombinant lubricin to articular cartilage surfaces. Journal of Orthopaedic Research 25 (3), pp.283-292. (10.1002/jor.20325)
- Young, R. D. et al. 2007. Differential immunogold localisation of sulphated and unsulphated keratan sulphate proteoglycans in normal and macular dystrophy cornea using sulphation motif-specific antibodies. Histochemistry and Cell Biology 127 (1), pp.115-120. (10.1007/s00418-006-0228-8)
2006
- Hayashida, Y. et al., 2006. Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. PNAS 103 (36), pp.13333-13338. (10.1073/pnas.0605441103)
- Grau, S. et al., 2006. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry 281 (10), pp.6124-6129. (10.1074/jbc.M500361200)
- Davies, L. et al., 2006. Comparing the responsiveness of chondrocytes isolated from young and mature articular cartilage to IGF-1 and TGFβ1. European Cells and Materials 12 (Supp 1), pp.54-54.
- Gealy, E. C. et al. 2006. Association between the cytoskeleton and collagen secretion in the developing cornea [Abstract]. International Journal of Experimental Pathology 87 (1), pp.A43-A44. (10.1111/j.0959-9673.2006.00458.x)
- Young, R. D. et al. 2006. Immunogold localization of keratan sulphate in macular corneal dystrophy using monoclonal antibodies to specific sulphation motifs [Abstract]. International Journal of Experimental Pathology 87 (1), pp.A49-A50. (10.1111/j.0959-9673.2006.00458.x)
2005
- Little, C. B. et al., 2005. Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and Cartilage 13 (2)(10.1016/j.joca.2004.10.014)
- Akhtar, S. , Davies, J. R. and Caterson, B. 2005. Ultrastructural immunolocalization of [alpha]-elastin and keratan sulfate proteoglycan in normal and scoliotic lumbar disc. Spine 30 (15), pp.1762-1769. (10.1097/01.brs.0000171912.44625.29)
- Hall, A. K. et al. 2005. Tissue-engineered cartilage grafts for use in cartilage repair technologies [Abstract]. International Journal of Experimental Pathology 86 (3), pp.A9. (10.1111/j.0959-9673.2005.00426.x)
- Hayes, A. J. et al. 2005. Novel chondroitin sulphation motifs as putative biomarkers of articular cartilage chondroprogenitor cells [Abstract]. European Cells and Materials 10 (Supp 2), pp.72.
- Innes, J. F. et al., 2005. Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis. American Journal of Veterinary Research 66 (10), pp.1679-1685. (10.2460/ajvr.2005.66.1679)
- Johnson, W. E. B. et al., 2005. Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in vitro. Spine 30 (10), pp.1139-1147. (10.1097/01.brs.0000162624.95262.73)
- Rees, S. G. et al. 2005. Catabolism of aggrecan proteoglycan aggregate components in short-term explant cultures of tendon. Matrix biology 24 (3), pp.219-231. (10.1016/j.matbio.2005.02.002)
- Young, R. D. et al. 2005. Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma. Investigative Ophthalmology and Visual Science 46 (6), pp.1973-1978. (10.1167/iovs.04-1309)
2004
- Kashiwagi, M. et al., 2004. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. Journal of Biological Chemistry 279 (11), pp.10109-10119. (10.1074/jbc.M312123200)
- Curtis, C. et al., 2004. The Effects of n-3 Polyunsaturated Fatty Acids on Cartilage Metabolism in Patients with Osteoarthritis: the Results of a Pilot Clinical Trial. Presented at: 3rd Euro Fed Lipid Congress Edinburgh, Scotland 5-8 September 2004.
- Curtis, C. L. et al., 2004. Biological basis for the benefit of nutraceutical supplementation in arthritis. Drug Discovery Today 9 (4), pp.165-172. (10.1016/S1359-6446(03)02980-5)
- Davies, L. C. , Caterson, B. and Duance, V. C. 2004. Novel strategies for enhancing tissue integration in cartilage repair. International Journal of Experimental Pathology 85 (1), pp.A21-A22. (10.1111/j.0959-9673.2004.369aa.x)
- Janusz, M. J. et al., 2004. Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. Osteoarthritis and Cartilage 12 (9), pp.720-728. (10.1016/j.joca.2004.06.004)
- Johnson, K. A. et al., 2004. Comparison of the effects of caudal pole hemi-meniscectomy and complete medial meniscectomy in the canine stifle joint. American Journal of Veterinary Research 65 (8), pp.1053-1060.
2003
- Harris, C. L. et al. 2003. Generation of anti-complement 'prodrugs': cleavable reagents for specific delivery of complement regulators to disease sites. The Journal of Biological Chemistry 278 (38), pp.36068-36076. (10.1074/jbc.M306351200)
- Connon, C. J. et al. 2003. Proteoglycan alterations and collagen reorganisation in the secondary avian cornea during development. Ophthalmic Research 35 (4), pp.177-184. (10.1159/000071168)
- Curtis, C. L. et al., 2003. The effect of n-3 (omega-3) polyunsaturated fatty acids on degenerative joint disease [review]. Agro Food Industry Hi-Tech 14 (3), pp.22-25.
- Gendron, C. et al., 2003. TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors. FEBS Letters 555 (3), pp.431-436. (10.1016/S0014-5793(03)01295-X)
- Hughes, C. E. , Little, C. B. and Caterson, B. 2003. Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols. Vol. 225, Methods in Molecular Biology Humana Press. , pp.89-98. (10.1385/1-59259-374-7:89)
2002
- Johnson, W. E. B. et al., 2002. Human intervertebral disc aggrecan inhibits nerve growth in vitro. Arthritis and Rheumatism 46 (10), pp.2658-2664. (10.1002/art.10585)
- Akhtar, S. et al. 2002. Scientific correspondence: clinical and morphological features including expression of βig-h3 and keratan sulphate proteoglycans in Maroteaux-Lamy syndrome type B and in normal cornea. British Journal of Ophthalmology 86 (2), pp.147-151. (10.1136/bjo.86.2.147)
- Curtis, C. L. et al., 2002. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids [RETRACTED]. Arthritis & Rheumatism 46 (6), pp.1544-1553. (10.1002/art.10305)
- Curtis, C. L. et al. 2002. Effects of n-3 fatty acids on cartilage metabolism [RETRACTED]. Proceedings of the Nutrition Society 61 (3), pp.381-389. (10.1079/PNS2002174)
- Fox, K. D. and Caterson, B. 2002. Freeing the brain from the perineuronal net. Science 298 (5596), pp.1187-1189. (10.1126/science.1079224)
- Johnson, K. A. et al., 2002. Cartilage-derived biomarkers of osteoarthritis in synovial fluid of dogs with naturally acquired rupture of the cranial cruciate ligament. American Journal of Veterinary Research 63 (6), pp.775-781.
- Little, C. B. et al., 2002. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis and Rheumatism - 46 (1), pp.124-129.
- Little, C. B. et al., 2002. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix biology 21 (3), pp.271-288. (10.1016/S0945-053X(02)00004-5)
- McK. Ciombor, D. et al., 2002. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. Journal of Orthopaedic Research 20 (1), pp.40-50. (10.1016/S0736-0266(01)00071-7)
- Quantock, A. J. et al. 2002. Keratan sulphate levels during development of the embryonic avian cornea. Investigative Ophthalmology and Visual Science 43 (E-Abst)
- Rees, S. G. et al. 2002. Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. Matrix biology 21 (7), pp.593-602. (10.1016/S0945-053X(02)00056-2)
2001
- Davies, J. R. et al., 2001. Appearance of a proteoglycan layer on the articular surface in murine antigen induced arthritis - Is this an accumulation of superficial zone proteoglycan (SZP)? [Poster Abstract]. International Journal of Experimental Pathology 82 (6), pp.A5. (10.1046/j.1365-2613.2001.82_6am.x)
- Little, C. B. et al., 2001. Species specificity of neoepitope antibodies to aggrecanase and MMP-generated sequences in the interglobular domain of aggrecan [Poster Abstract]. International Journal of Experimental Pathology 82 (6), pp.A12. (10.1046/j.1365-2613.2001.82_6am.x)
- Rees, S. G. et al., 2001. Expression and immunolocalization of superficial zone proteoglycan (SZP) in tendon. International Journal of Experimental Pathology 82 (6), pp.A16-A17.
- Roberts, S. et al., 2001. Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation. Arthritis & Rheumatism 44 (11), pp.2586-2598.
2000
- Caterson, B. et al. 2000. Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biology 19 (4), pp.333-344. (10.1016/S0945-053X(00)00078-0)
- Curtis, C. L. et al., 2000. n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation. Journal of Biological Chemistry 275 (2), pp.721-724. (10.1074/jbc.275.2.721)
- Flannery, C. R. et al., 2000. IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix biology 19 (6), pp.549-553. (10.1016/S0945-053X(00)00111-6)
- Hiscock, D. R. R. , Caterson, B. and Flannery, C. R. 2000. Expression of hyaluronan synthases in articular cartilage. Osteoarthritis and Cartilage 8 (2), pp.120-126. (10.1053/joca.1999.0280)
- Rees, S. G. et al. 2000. Catabolism of aggrecan, decorin and biglycan in tendon. Biochemical Journal 350 (1), pp.181-188. (10.1042/0264-6021:3500181)
- Roberts, S. et al., 2000. Matrix metalloproteinases and aggrecanase. Spine 25 (23), pp.3005-3013. (10.1097/00007632-200012010-00007)
Adrannau llyfrau
- Bondeson, J. et al. 2025. ADAMTS4. In: Rawlings, N. D. and Auld, D. S. eds. Handbook of Proteolytic Enzymes. 4th ed.. London: Academic Press. , pp.1263-1273. (10.1016/B978-0-443-28849-4.00196-X)
- Bondeson, J. et al. 2013. ADAMTS4. In: Rawlings, N. D. and Salvesen, G. eds. Handbook of Proteolytic Enzymes. 3rd ed.. Vol. 1, London: Academic Press. , pp.1166-1173. (10.1016/B978-0-12-382219-2.00262-3)
- Bondeson, J. et al. 2013. ADAMTS5. In: Rawlings, N. D. and Salvesen, G. eds. Handbook of Proteolytic Enzymes. 3rd ed.. Vol. 1, London: Academic Press. , pp.1174-1180. (10.1016/B978-0-12-382219-2.00263-5)
- Hughes, C. E. , Little, C. B. and Caterson, B. 2003. Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis. In: Winyard, P. G. and Willoughby, D. A. eds. Inflammation Protocols. Vol. 225, Methods in Molecular Biology Humana Press. , pp.89-98. (10.1385/1-59259-374-7:89)
Cynadleddau
- Caterson, B. 2014. The effect of mycotoxins and selenium on the modification of cartilage proteoglycan sulphation. Presented at: 3rd International Conference on Selenium in the Environment and Human Health Hefei, China 10-14 November 2013. Published in: Banuelos, G. S. , Lin, Z. and Yin, X. eds. Selenium in the Environment and Human Health: Proceedings of the 3rd International Conference on Selenium in the Environment and Human Health. Boca Raton, Florida: CRC Press.
- Curtis, C. et al., 2004. The Effects of n-3 Polyunsaturated Fatty Acids on Cartilage Metabolism in Patients with Osteoarthritis: the Results of a Pilot Clinical Trial. Presented at: 3rd Euro Fed Lipid Congress Edinburgh, Scotland 5-8 September 2004.
Erthyglau
- Zhang, W. et al., 2027. Regulation of epithelial-mesenchymal cell-cell partners by complexes of paracrine signals and sulfated oligosaccharides. Biomaterials 336 124461. (10.1016/j.biomaterials.2026.124461)
- Nandadasa, S. et al., 2020. Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth. eLife 9 e60683. (10.7554/eLife.60683)
- Tribble, J. R. et al. 2018. Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma. Molecular Brain 11 (1) 69. (10.1186/s13041-018-0412-5)
- Hayes, A. J. et al. 2018. Concise Review: Stem/progenitor cell proteoglycans decorated with 7-D-4, 4-C-3, and 3-B-3(-) chondroitin sulfate motifs are morphogenetic markers of tissue development. STEM CELLS 36 (10), pp.1475-1486. (10.1002/stem.2860)
- Caterson, B. and Melrose, J. 2018. Keratan sulfate, a complex glycosaminoglycan with unique functional capability. Glycobiology 28 (4), pp.182-206. (10.1093/glycob/cwy003)
- Littlechild, S. et al. 2018. Keratan sulfate phenotype in the β-1,3-N-acetylglucosaminyltransferase-7-null mouse cornea. Investigative Ophthalmology and Visual Science 59 , pp.1641-1651. (10.1167/iovs.17-22716)
- Hayes, A. et al. 2018. Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis. Biochemical Journal 475 (3), pp.587-620. (10.1042/BCJ20170820)
- Powell, A. et al. 2017. Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?. Journal of Drug Targeting 25 (9-10), pp.919-926. (10.1080/1061186X.2017.1378660)
- Brown, S. et al., 2017. Contaminants in commercial preparations of 'purified' small leucine-rich proteoglycans may distort mechanistic studies. Bioscience Reports 37 (1) BSR20160465. (10.1042/BSR20160465)
- Hayes, A. J. et al. 2016. The CS sulphation motifs 4C3, 7D4, 3B3[-]; and perlecan identify stem cell populations and niches, activated progenitor cells and transitional tissue development in the fetal human elbow. Stem Cells and Development 25 (11), pp.836-847. (10.1089/scd.2016.0054)
- Farrugia, B. L. et al., 2016. Mast cells produce a unique chondroitin sulfate epitope. Journal of Histochemistry and Cytochemistry 64 (2), pp.85-98. (10.1369/0022155415620649)
- Bascoul-Colombo, C. et al., 2016. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1α in bovine cartilage explants. Cartilage 7 (1), pp.70-81. (10.1177/1947603515603762)
- Yamada, K. et al., 2015. Mesenchymal-epithelial cell interactions and proteoglycan matrix composition in the presumptive stem cell niche of the rabbit corneal limbus. Molecular Vision 21 , pp.1328-1329.
- Roberts, S. et al., 2015. ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage 23 (9), pp.1622-1626. (10.1016/j.joca.2015.05.006)
- Beckett, M. C. et al., 2015. The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc. European Cells and Materials 30 , pp.69-88.
- Esa, A. et al. 2015. Investigating the role of Wnt antagonist protein Dkk-1 in the pathogenesis of osteoarthritis [Abstract]. International Journal of Experimental Pathology 96 (2), pp.A29-A29. (10.1111/iep.12125)
- Pantazopoulos, H. et al., 2015. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Translational Psychiatry 5 (1) e496. (10.1038/tp.2014.128)
- Chen, J. et al., 2015. Altered proteolytic activity and expression of mmps and aggrecanases and their inhibitors in Kashin-Beck disease. Journal of Orthopaedic Research 33 (1), pp.47-55. (10.1002/jor.22708)
- Fu, Q. et al., 2015. Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study. Osteoarthritis and Cartilage 23 (6), pp.868-873. (10.1016/j.joca.2015.01.009)
- Turner, S. et al., 2014. Viability, growth kinetics and stem cell markers of single and clustered cells in human intervertebral discs: implications for regenerative therapies. European Spine Journal 23 (11), pp.2462-2472. (10.1007/s00586-014-3500-y)
- Li, S. et al., 2014. Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS ONE 9 (10) e109536. (10.1371/journal.pone.0109536)
- Ho, L. T. Y. et al. 2014. A comparison of glycosaminoglycan distributions, keratan sulphate sulphation patterns and collagen fibril architecture from central to peripheral regions of the bovine cornea. Matrix Biology 38 , pp.59-68. (10.1016/j.matbio.2014.06.004)
- Luo, M. et al., 2014. Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease. Osteoarthritis and Cartilage 22 (7), pp.986-995. (10.1016/j.joca.2014.05.012)
- Sivan, S. S. et al., 2014. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. European Spine Journal 23 (3), pp.344-353. (10.1007/s00586-013-2767-8)
- Smith, R. et al., 2014. Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal 46 (1), pp.4-9. (10.1111/evj.12128)
- Lord, M. S. et al., 2013. Sulfation of the Bikunin Chondroitin Sulfate Chain Determines Heavy Chain·Hyaluronan Complex Formation. Journal of Biological Chemistry 288 (32), pp.22930-22941. (10.1074/jbc.M112.404186)
- Roberts, S. , Fuller, H. and Caterson, B. 2013. Contamination: Uphold standards for lab reagents [Letter]. Nature 496 (7445), pp.300. (10.1038/496300c)
- Coulson-Thomas, V. J. , Caterson, B. and Kao, W. W. 2013. Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of Mucopolysaccharidosis VII mice. Stem Cells 31 (10), pp.2116-2126. (10.1002/stem.1481)
- Guan, F. et al., 2013. Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions. Rheumatology International 33 (1), pp.157-166. (10.1007/s00296-011-2335-7)
- Hayes, A. J. et al. 2013. Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental Dynamics 242 (6), pp.778-789. (10.1002/dvdy.23970)
- Hayes, A. J. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8 (9), pp.e75787. (10.1371/journal.pone.0075787)
- Li, S. et al., 2013. The effect of beta-xylosides on the chondrogenic differentiation of mesenchymal stem cells. Histochemistry and Cell Biology 139 (1), pp.59-74. (10.1007/s00418-012-1017-1)
- Sheeran, L. et al. 2013. Classification-guided versus generalized postural intervention in subgroups of nonspecific chronic low back pain: a pragmatic randomized controlled study. Spine 38 (19), pp.1613-1625. (10.1097/BRS.0b013e31829e049b)
- Shu, C. et al., 2013. The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal 30 (7), pp.717-725. (10.1007/s10719-013-9475-9)
- Wainwright, S. D. et al. 2013. ADAMTS4_v1 is a splice variant of ADAMTS4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain. Arthritis & Rheumatism 65 (11), pp.2866-2875. (10.1002/art.38102)
- Sheeran, L. et al. 2012. Spinal position sense and trunk muscle activity during sitting and standing in non-specific chronic low back pain: classification analysis. Spine 37 (8), pp.E486-E495. (10.1097/BRS.0b013e31823b00ce)
- Serpi, M. et al. 2012. Novel phosphoramidate prodrugs of N-Acetyl-(d)-Glucosamine with antidegenerative activity on bovine and human cartilage explants. Journal of Medicinal Chemistry 55 (10), pp.4629-4639. (10.1021/jm300074y)
- Bara, J. J. et al., 2012. Articular Cartilage Glycosaminoglycans Inhibit the Adhesion of Endothelial Cells. Connective Tissue Research 53 (3), pp.220-228. (10.3109/03008207.2011.629310)
- Brown, S. et al., 2012. A comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discs. European Spine Journal 21 (S2), pp.154-159. (10.1007/s00586-012-2179-1)
- Caterson, B. 2012. Fell-Muir Lecture: Chondroitin sulphate glycosaminoglycans: fun for some and confusion for others. International Journal of Experimental Pathology 93 (1), pp.1-10. (10.1111/j.1365-2613.2011.00807.x)
- Hatzirodos, N. et al., 2012. Glycomic analyses of ovarian follicles during development and atresia. Matrix Biology 31 (1), pp.45-56. (10.1016/j.matbio.2011.10.002)
- Li, S. et al., 2012. Proteoglycan metabolism, cell death and Kashin-Beck Disease. Glycoconjugate Journal 29 (5-6), pp.241-248. (10.1007/s10719-012-9421-2)
- Lu, M. et al., 2012. The Effects of Mycotoxins and Selenium Deficiency on Tissue-Engineered Cartilage. Cells Tissues Organs 196 (3), pp.241-250. (10.1159/000335046)
- Melrose, J. et al., 2012. Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology 138 (3), pp.461-475. (10.1007/s00418-012-0968-6)
- Phitak, T. et al., 2012. Chondroprotective and anti-inflammatory effects of sesamin. Phytochemistry 80 , pp.77-88. (10.1016/j.phytochem.2012.05.016)
- Schwend, T. et al., 2012. Corneal sulfated glycosaminoglycans and their effects on trigeminal nerve growth cone behavior in vitro: roles for ECM in cornea innervation. Investigative Ophthalmology and Visual Science 53 (13), pp.8118-8137. (10.1167/iovs.12-10832)
- Taylor, D. W. et al., 2012. Hyaline cartilage tissue is formed through the co-culture of passaged human chondrocytes and primary bovine chondrocytes. Journal of Histochemistry & Cytochemistry 60 (8), pp.576-587. (10.1369/0022155412449018)
- Wainwright, S. D. et al. 2012. Human osteoarthritis synovium contains an alternatively spliced transcript of ADAMTS4 [Abstract]. Osteoarthritis and Cartilage 20 (S1), pp.S136. (10.1016/j.joca.2012.02.185)
- Akhtar, S. et al., 2011. Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 249 (3), pp.413-420. (10.1007/s00417-010-1512-9)
- Hayes, A. J. et al. 2011. Chondroitin sulphate sulphation motif expression in the ontogeny of the intervertebral disc. European Cells and Materials 21 , pp.1-14.
- Hayes, A. J. et al. 2011. Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc. European Cells and Materials 22 , pp.226-241.
- Bondeson, J. et al. 2010. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis & Rheumatism 62 (3), pp.647-657. (10.1002/art.27290)
- Liles, M. et al., 2010. Differential relative sulfation of keratan sulfate glycosaminoglycan in the chick cornea during embryonic development. Investigative Ophthalmology and Visual Science 51 (3), pp.1365-1372. (10.1167/iovs.09-4004)
- Gabriel, N. et al., 2010. Development of an in vitro model of feline cartilage degradation. Journal of Feline Medicine & Surgery 12 (8), pp.614-620. (10.1016/j.jfms.2010.03.007)
- Hurst, S. et al., 2010. Dietary fatty acids and arthritis. Prostaglandins Leukotrienes & Essential Fatty Acids 82 (4-6), pp.315-318. (10.1016/j.plefa.2010.02.008)
- Ralphs, J. R. et al. 2010. Chondroitin sulphate sulfation motifs in intervertebral disc development [Abstract]. European Cells and Materials 20 (Supp 2), pp.3.
- Yang, B. et al., 2010. In vitrocartilage tissue engineering using cancellous bone matrix gelatin as a biodegradable scaffold. Biomedical Materials 5 (4) 045003. (10.1088/1748-6041/5/4/045003)
- Zhang, A. et al., 2010. Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease. Journal of Zhejiang University-Science B 11 (3), pp.200-208. (10.1631/jzus.B0900074)
- Clarkin, C. E. et al., 2009. Phenotypic plasticity of superficial zone chondrocytes is revealed by increased glycosaminoglycan release and a unique angiogenic secretory profile from neo-cartilage grafts [Abstract]. International Journal of Experimental Pathology 90 (2), pp.A103-A104. (10.1111/j.1365-2613.2009.00644.x)
- Gealy, E. C. et al. 2009. Actin and type I collagen propeptide distribution in the developing chick cornea. Investigative Ophthalmology & Visual Science 50 (4), pp.1653 -1658. (10.1167/iovs.08-2554)
- Hurst, S. et al., 2009. Contrasting Effects of n-3 and n-6 Fatty Acids on Cyclooxygenase-2 in Model Systems for Arthritis. Lipids 44. (10), pp.889-896. (10.1007/s11745-009-3347-x)
- Rees, S. G. , Dent, C. M. and Caterson, B. 2009. Metabolism of proteoglycans in tendon. Scandinavian Journal of Medicine & Science in Sports 19 (4), pp.470-478. (10.1111/j.1600-0838.2009.00938.x)
- Rees, S. G. et al., 2009. Immunolocalisation and expression of keratocan in tendon. Osteoarthritis and Cartilage 17 (2), pp.276-279. (10.1016/j.joca.2008.07.007)
- Roberts, H. C. et al. 2009. Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation. International Journal of Experimental Pathology 90 (1), pp.A78-A79.
- Roberts, H. C. et al. 2009. Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation [Abstract]. International Journal of Experimental Pathology 90 (1), pp.A78-A79. (10.1111/j.1365-2613.2008.00612.x)
- Zainal, Z. et al., 2009. Modification of Palm Oil for Anti-Inflammatory Nutraceutical Properties. Lipids 44 (7), pp.581-592. (10.1007/s11745-009-3304-8)
- Zainal, Z. et al., 2009. Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis and Cartilage 17 (7), pp.896-905. (10.1016/j.joca.2008.12.009)
- Akhtar, S. et al., 2008. Immunochemical localisation of keratan sulphate proteoglycans in cornea, sclera and limbus using a keratanase generated neoepitope monoclonal antibody. Investigative Ophthalmology and Visual Science 49 (6), pp.2424-2431. (10.1167/iovs.06-1498)
- Bondeson, J. et al. 2008. The regulation of ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review. Clinical and Experimental Rheumatology 26 (1), pp.139-145.
- Cao, J. et al., 2008. Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China. Osteoarthritis and Cartilage 16 (6), pp.680-8. (10.1016/j.joca.2007.09.002)
- Caterson, B. et al. 2008. Chondroitin sulphate motifs as biomarkers for the stem/progenitor cell niche in musculoskeletal tissues. European Cells and Materials 16 (Supp 2), pp.47-47.
- Davies, L. C. et al., 2008. The potential of IGF-1 and TGFβ1 for promoting “adult” articular cartilage repair: An in vitro study. Tissue Engineering Part A 14 (7), pp.1251-1261. (10.1089/ten.tea.2007.0211)
- Davies, L. C. et al. 2008. Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes. Osteoarthritis and Cartilage 16 (8), pp.855-864. (10.1016/j.joca.2007.12.005)
- Hayes, A. J. , Hughes, C. E. and Caterson, B. 2008. Antibodies and immunohistochemistry in extracellular matrix research. Methods 45 (1), pp.10-21. (10.1016/j.ymeth.2008.01.011)
- Hayes, A. J. et al. 2008. Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry & Cytochemistry 56 (2), pp.125-38. (10.1369/jhc.7A7320.2007)
- Khan, I. M. et al. 2008. Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage. Osteoarthritis and Cartilage 16 (6), pp.698-707. (10.1016/j.joca.2007.10.004)
- Li, S. et al., 2008. Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. Journal of Zhejiang University-Science B 9 (1), pp.22-33. (10.1631/jzus.B071322)
- McGuigan, C. et al. 2008. Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery. Journal of Medicinal Chemistry 51 (18), pp.5807-5812. (10.1021/jm800594c)
- Melrose, J. et al., 2008. Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research & Therapy 10 (4) R79. (10.1186/ar2453)
- Young, R. D. et al. 2007. Keratan sulfate glycosaminoglycan and the association with collagen fibrils in rudimentary lamellae in the developing avian cornea. Investigative Ophthalmology and Visual Science 48 (7), pp.3083-3088. (10.1167/iovs.06-1323)
- Rees, S. G. et al., 2007. Inhibition of aggrecan turnover in short-term explant cultures of bovine tendon. Matrix Biology 26 (4), pp.280-290. (10.1016/j.matbio.2007.01.003)
- Bondeson, J. et al. 2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. The Journal of Rheumatology 34 (3), pp.523-533.
- Fang, S. C. et al., 2007. Fracture healing and its potential as a bioreactor for skeletal tissue engineering. European Cells and Materials 13 (Supp 2), pp.28-29.
- Gealy, E. C. et al. 2007. Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis. Histochemistry and Cell Biology 128 (6), pp.551-555. (10.1007/s00418-007-0332-4)
- Gendron, C. et al., 2007. Proteolytic activities of human ADAMTS-5: Comparative studies wth ADAMTS - 4. Journal of Biological Chemistry 282 (25), pp.18294-18306. (10.1074/jbc.M701523200)
- Hayes, A. J. et al. 2007. Macromolecular organization and in vitro growth characteristics of scaffold-free neocartilage grafts. Journal of Histochemistry & Cytochemistry 55 (8), pp.853-866. (10.1369/jhc.7A7210.2007)
- Jones, A. R. et al., 2007. Binding and localization of recombinant lubricin to articular cartilage surfaces. Journal of Orthopaedic Research 25 (3), pp.283-292. (10.1002/jor.20325)
- Young, R. D. et al. 2007. Differential immunogold localisation of sulphated and unsulphated keratan sulphate proteoglycans in normal and macular dystrophy cornea using sulphation motif-specific antibodies. Histochemistry and Cell Biology 127 (1), pp.115-120. (10.1007/s00418-006-0228-8)
- Hayashida, Y. et al., 2006. Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. PNAS 103 (36), pp.13333-13338. (10.1073/pnas.0605441103)
- Grau, S. et al., 2006. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry 281 (10), pp.6124-6129. (10.1074/jbc.M500361200)
- Davies, L. et al., 2006. Comparing the responsiveness of chondrocytes isolated from young and mature articular cartilage to IGF-1 and TGFβ1. European Cells and Materials 12 (Supp 1), pp.54-54.
- Gealy, E. C. et al. 2006. Association between the cytoskeleton and collagen secretion in the developing cornea [Abstract]. International Journal of Experimental Pathology 87 (1), pp.A43-A44. (10.1111/j.0959-9673.2006.00458.x)
- Young, R. D. et al. 2006. Immunogold localization of keratan sulphate in macular corneal dystrophy using monoclonal antibodies to specific sulphation motifs [Abstract]. International Journal of Experimental Pathology 87 (1), pp.A49-A50. (10.1111/j.0959-9673.2006.00458.x)
- Little, C. B. et al., 2005. Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and Cartilage 13 (2)(10.1016/j.joca.2004.10.014)
- Akhtar, S. , Davies, J. R. and Caterson, B. 2005. Ultrastructural immunolocalization of [alpha]-elastin and keratan sulfate proteoglycan in normal and scoliotic lumbar disc. Spine 30 (15), pp.1762-1769. (10.1097/01.brs.0000171912.44625.29)
- Hall, A. K. et al. 2005. Tissue-engineered cartilage grafts for use in cartilage repair technologies [Abstract]. International Journal of Experimental Pathology 86 (3), pp.A9. (10.1111/j.0959-9673.2005.00426.x)
- Hayes, A. J. et al. 2005. Novel chondroitin sulphation motifs as putative biomarkers of articular cartilage chondroprogenitor cells [Abstract]. European Cells and Materials 10 (Supp 2), pp.72.
- Innes, J. F. et al., 2005. Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis. American Journal of Veterinary Research 66 (10), pp.1679-1685. (10.2460/ajvr.2005.66.1679)
- Johnson, W. E. B. et al., 2005. Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in vitro. Spine 30 (10), pp.1139-1147. (10.1097/01.brs.0000162624.95262.73)
- Rees, S. G. et al. 2005. Catabolism of aggrecan proteoglycan aggregate components in short-term explant cultures of tendon. Matrix biology 24 (3), pp.219-231. (10.1016/j.matbio.2005.02.002)
- Young, R. D. et al. 2005. Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma. Investigative Ophthalmology and Visual Science 46 (6), pp.1973-1978. (10.1167/iovs.04-1309)
- Kashiwagi, M. et al., 2004. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. Journal of Biological Chemistry 279 (11), pp.10109-10119. (10.1074/jbc.M312123200)
- Curtis, C. L. et al., 2004. Biological basis for the benefit of nutraceutical supplementation in arthritis. Drug Discovery Today 9 (4), pp.165-172. (10.1016/S1359-6446(03)02980-5)
- Davies, L. C. , Caterson, B. and Duance, V. C. 2004. Novel strategies for enhancing tissue integration in cartilage repair. International Journal of Experimental Pathology 85 (1), pp.A21-A22. (10.1111/j.0959-9673.2004.369aa.x)
- Janusz, M. J. et al., 2004. Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. Osteoarthritis and Cartilage 12 (9), pp.720-728. (10.1016/j.joca.2004.06.004)
- Johnson, K. A. et al., 2004. Comparison of the effects of caudal pole hemi-meniscectomy and complete medial meniscectomy in the canine stifle joint. American Journal of Veterinary Research 65 (8), pp.1053-1060.
- Harris, C. L. et al. 2003. Generation of anti-complement 'prodrugs': cleavable reagents for specific delivery of complement regulators to disease sites. The Journal of Biological Chemistry 278 (38), pp.36068-36076. (10.1074/jbc.M306351200)
- Connon, C. J. et al. 2003. Proteoglycan alterations and collagen reorganisation in the secondary avian cornea during development. Ophthalmic Research 35 (4), pp.177-184. (10.1159/000071168)
- Curtis, C. L. et al., 2003. The effect of n-3 (omega-3) polyunsaturated fatty acids on degenerative joint disease [review]. Agro Food Industry Hi-Tech 14 (3), pp.22-25.
- Gendron, C. et al., 2003. TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors. FEBS Letters 555 (3), pp.431-436. (10.1016/S0014-5793(03)01295-X)
- Johnson, W. E. B. et al., 2002. Human intervertebral disc aggrecan inhibits nerve growth in vitro. Arthritis and Rheumatism 46 (10), pp.2658-2664. (10.1002/art.10585)
- Akhtar, S. et al. 2002. Scientific correspondence: clinical and morphological features including expression of βig-h3 and keratan sulphate proteoglycans in Maroteaux-Lamy syndrome type B and in normal cornea. British Journal of Ophthalmology 86 (2), pp.147-151. (10.1136/bjo.86.2.147)
- Curtis, C. L. et al., 2002. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids [RETRACTED]. Arthritis & Rheumatism 46 (6), pp.1544-1553. (10.1002/art.10305)
- Curtis, C. L. et al. 2002. Effects of n-3 fatty acids on cartilage metabolism [RETRACTED]. Proceedings of the Nutrition Society 61 (3), pp.381-389. (10.1079/PNS2002174)
- Fox, K. D. and Caterson, B. 2002. Freeing the brain from the perineuronal net. Science 298 (5596), pp.1187-1189. (10.1126/science.1079224)
- Johnson, K. A. et al., 2002. Cartilage-derived biomarkers of osteoarthritis in synovial fluid of dogs with naturally acquired rupture of the cranial cruciate ligament. American Journal of Veterinary Research 63 (6), pp.775-781.
- Little, C. B. et al., 2002. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis and Rheumatism - 46 (1), pp.124-129.
- Little, C. B. et al., 2002. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix biology 21 (3), pp.271-288. (10.1016/S0945-053X(02)00004-5)
- McK. Ciombor, D. et al., 2002. Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. Journal of Orthopaedic Research 20 (1), pp.40-50. (10.1016/S0736-0266(01)00071-7)
- Quantock, A. J. et al. 2002. Keratan sulphate levels during development of the embryonic avian cornea. Investigative Ophthalmology and Visual Science 43 (E-Abst)
- Rees, S. G. et al. 2002. Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. Matrix biology 21 (7), pp.593-602. (10.1016/S0945-053X(02)00056-2)
- Davies, J. R. et al., 2001. Appearance of a proteoglycan layer on the articular surface in murine antigen induced arthritis - Is this an accumulation of superficial zone proteoglycan (SZP)? [Poster Abstract]. International Journal of Experimental Pathology 82 (6), pp.A5. (10.1046/j.1365-2613.2001.82_6am.x)
- Little, C. B. et al., 2001. Species specificity of neoepitope antibodies to aggrecanase and MMP-generated sequences in the interglobular domain of aggrecan [Poster Abstract]. International Journal of Experimental Pathology 82 (6), pp.A12. (10.1046/j.1365-2613.2001.82_6am.x)
- Rees, S. G. et al., 2001. Expression and immunolocalization of superficial zone proteoglycan (SZP) in tendon. International Journal of Experimental Pathology 82 (6), pp.A16-A17.
- Roberts, S. et al., 2001. Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation. Arthritis & Rheumatism 44 (11), pp.2586-2598.
- Caterson, B. et al. 2000. Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biology 19 (4), pp.333-344. (10.1016/S0945-053X(00)00078-0)
- Curtis, C. L. et al., 2000. n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation. Journal of Biological Chemistry 275 (2), pp.721-724. (10.1074/jbc.275.2.721)
- Flannery, C. R. et al., 2000. IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix biology 19 (6), pp.549-553. (10.1016/S0945-053X(00)00111-6)
- Hiscock, D. R. R. , Caterson, B. and Flannery, C. R. 2000. Expression of hyaluronan synthases in articular cartilage. Osteoarthritis and Cartilage 8 (2), pp.120-126. (10.1053/joca.1999.0280)
- Rees, S. G. et al. 2000. Catabolism of aggrecan, decorin and biglycan in tendon. Biochemical Journal 350 (1), pp.181-188. (10.1042/0264-6021:3500181)
- Roberts, S. et al., 2000. Matrix metalloproteinases and aggrecanase. Spine 25 (23), pp.3005-3013. (10.1097/00007632-200012010-00007)
Patentau
- Caterson, B. et al. 2010. Method for decreasing cartilage damage in dogs. US20100261793A1[Patent]
Ymchwil
Figure1: Monoclonal Antibodies to GAG sulphation Motif Epitopes and Neoepitopes on Aggrecan, Aggrecanase-generated Catabolites and Link Protein
Over the past 27 years Professor Bruce Caterson’s research has focussed on the production, development and use of monoclonal antibody (mAb) technologies for studies of connective tissue proteoglycan metabolism in health and disease. These studies have focussed on matrix proteoglycan metabolism in musculoskeletal tissues with a particular emphasis on studies involving molecular mechanism underlying the pathogenesis of degenerative joint diseases; i.e. osteoarthritis and rheumatoid arthritis. Our lab has now developed and characterised numerous mAbs that recognise both carbohydrate and protein epitopes and neoepitopes that are present on proteoglycans in all connective tissues throughout the body (see Figure 1 and publications, as recent examples). Many of these mAbs are now commercially available to researchers worldwide.
Figure 2:
Immunochemical identification of stem/progenitor cells in the surface/superficial zone of articular cartilage: Immunohistochemical localisation of cell surface and matrix proteoglycans containing native chondroitin sulphate (CS) glycosaminoglycan (GAG) sulphation motifs recognised by monoclonal antibodies 4-C-3(-) and 7-D-4(-). These antibodies identify the pericellular environment surrounding stem/progenitor cells located in the surface/superficial zone of 7-day old bovine articular cartilage. Antibody 4-C-3(-) also recognises CS on proteoglycans surrounding cells (pericytes?) in small blood vessels located in the calcified zone of the immature cartilage.
These reagents and technologies are also being applied to development of new antibody-based biomarker assays to diagnose and monitor the efficacy of therapeutic or surgical interventions in the treatment of degenerative joint diseases and changes in matrix proteoglycan and protein metabolism associated changes in the peri-neuronal net in the pathogenesis of Alzheimer’s disease. Furthermore, these mAb technologies have been applied to tissue engineering & tissue regeneration applications involving the repair of articular cartilage and other musculoskeletal tissues (7, 10). In recent years, these research interests have extended to several collaborative studies investigating proteoglycan metabolism and extracellular matrix organisation in the cornea of the eye during development and with the onset of pathology (2, 4). Very recent work (10) has used several monoclonal antibodies that recognise chondroitin sulphate (CS) glycosaminoglycan sulphation motifs to identify stem/progenitor cells in their “stem cell niches” of musculoskeletal tissues (i.e. cartilage, tendon and intervertebral disc), the eye and the gut of several different animal species (see Figures 2 above & 3 below).
Figure 3:Chondroitin sulphate (CS) glycosaminoglycan (GAG) sulphation motifs and the “stem/progenitor cell niche”:(A) Hyaluronan (HA) bound to CD44 and minimally sulphated CS GAG chains occur on cell surface and matrix proteoglycans and form a protective barrier around stem/progenitor cells in the tissue matrix. These lowly sulphat'ed CS proteoglycans and HA have a low affinity for binding and/or presentation of growth factors, cytokines and chemokines to the dormant stem/progenitor cell. However, many of these growth factors are sequestered on more abundant and highly sulphated CS GAG chains in the territorial and extracellular matrix of the tissue; (B) After being presented with an activating stimulus (e.g. mechanical stress, matrix depletion), the stem/progenitor cell is stimulated to divide and produce two daughter cells. This division physically pushes one of the daughter cells out into the territorial matrix where its cell surface receptors can now interact with growth factors & chemokines already bound to more highly sulphated CS and other GAGs with conformations favourable for receptor binding. (C) These interactions with cell surface receptors stimulate this one daughter cell to proliferate and further differentiate down a chondrocytic lineage. The other daughter cell remains in the “stem/progenitor cell niche” protected from stimulation by growth factors, cytokine and chemokines by the lesser sulphated CS GAGs on proteoglycan and hyaluronan bound to CD44 surrounding this still naive stem/progenitor daughter cell.
Current Funding
- Arthritis Research Campaign
- BBSRC
- EPSRC
- Alzheimer’s Research Fund
- Industry
Funded Collaborations
Cardiff University
Professor John L. Harwood, Head of School, School of Biosciences: Effects of n-3 fatty acids on brain peri-neuronal net metabolism in the pathogenesis of Alzheimer’s disease.
Mr Colin Dent, FRCS (Orth), Professor of Orthopaedics & Trauma, School of Medicine: Tendon matrix proteoglycan metabolism in health and disease. Biomarkers for musculoskeletal diseases.
and Dr Andrew Quantok, School of Optometry: Corneal matrix organisation and metabolism during development and pathology.
Professor Ruth Duncan, School of Pharmacy and Dr Peter Griffith, School of Chemistry: Nanotechnology drug delivery systems for treatment of arthritic diseases.
Professor Chris McGuigan, School of Pharmacy: The beneficial effects of chemically-modified glucosamine on cartilage metabolism in the pathogenesis of osteoarthritis.
Dr Jan Bondeson, Rheumatology, School of Medicine: Regulation of aggrecanases and matrix metalloproteinase expression in the pathogenesis of degenerative joint diseases.
Dr Jim Ralphs, School of Biosciences: Corneal matrix organisation during development.
National
Dr Sally Roberts & Professor James B. Richardson, RJAH Orthopaedic Hospital, Oswestry: Biomarkers for degenerative joint and disc disease.
Professor Richard Oreffo, Department of Orthopaedics, University of Southhampton: Glycosaminoglycan and polymer scaffolds for tissue engineering and regeneration.
Dr Sarah G. Rees, School of Medicine, Swansea University: Tendon proteoglycan metabolism in health and disease.
International
Dr Virginia Kraus, Department of Rheumatology, Duke University, Durham, NC, USA: Biomarkers of musculoskeletal diseases & cartilage metabolism in the pathogenesis of Kashin-Beck disease.
Professor Junling Cao, Institute of Endemic Diseases, Xi’an Jiaotong Medical University, Xi’an, China: Cartilage metabolism in the pathogenesis of Kashin-Beck Disease.
Dr Chris B. Little, Director, Raymond Purves Institute of Bone and Joint Research, University of Sydney, Australia: Proteoglycan metabolism in cartilage and intervertebral disc disease.
Affiliated Staff
Senior Lecturer
Visiting Clinical Fellow
Mrs Amy Morgan
Scientific Officer
Postdoctoral Researchers
Dr Helen Roberts
Orthopaedic Surgery Registrar Trainees
Contact Details
[email protected]
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX