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John Harwood
Athro Emeritws
Ysgol y Biowyddorau
Trosolwyg
Trosolwg ymchwil
Mae ymchwil yn y gorffennol a'r presennol yn fy labordy yn canolbwyntio ar fetabolaeth a swyddogaeth lipidau acyl. Mae'r gwaith hwn wedi cynnwys egluro llwybrau metabolaidd newydd, ynysu ac astudio ensymau pwysig a phenlinio mecanweithiau rheoleiddio. Ar gyfer yr olaf, rydym wedi arloesi cymhwyso dadansoddiad rheoli fflwcs i fiosynthesis lipid. Ar hyn o bryd ranked rhif 2 yn y byd fel ysgolhaig ranked iawn ymchwilio metaboledd lipid.
Mae ymchwil wedi'i seilio mewn tri phrif faes. Yn gyntaf, rydym wedi astudio effaith straen amgylcheddol ar metaboledd lipid. Yn ail, rydym wedi archwilio biosynthesis lipidau planhigion gwahanol a mecanweithiau rheoleiddio. Mae'r gwaith hwn wedi cynnwys lipidau bilen a storio a'u asidau brasterog cyfansoddol. Mae trydydd maes yn ymwneud â chwynion meddygol lle mae lipidau yn chwarae rhan allweddol. Arthritis, clefyd cardiofasgwlaidd a dementia yw'r tri phrif ffoci.
Cyhoeddiad
2024
- Weselake, R. J., Fell, D. A., Wang, X., Scofield, S., Chen, G. and Harwood, J. L. 2024. Increasing oil content in Brassica oilseed species. Progress in Lipid Research 96, article number: 101306. (10.1016/j.plipres.2024.101306)
2023
- Fell, D. A., Taylor, D. C., Weselake, R. J. and Harwood, J. L. 2023. Metabolic control analysis of triacylglycerol accumulation in oilseed rape. BioSystems 227-22, article number: 104905. (10.1016/j.biosystems.2023.104905)
- Harwood, J. L. 2023. Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources. International Journal of Molecular Sciences 24(10), article number: 8838. (10.3390/ijms24108838)
2022
- Chen, G., Harwood, J. L., Lemieux, M. J., Stone, S. J. and Weselake, R. J. 2022. Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control. Progress in Lipid Research 88, article number: 101181. (10.1016/j.plipres.2022.101181)
- Fuchs, L. K. et al. 2022. Genetic manipulation of biosynthetic pathways in mint. Frontiers in Plant Science 13, article number: 928178. (10.3389/fpls.2022.928178)
- Fenyk, S. et al. 2022. Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation. Biochemical Journal 479(6), pp. 805-823. (10.1042/BCJ20220003)
- Liao, P. et al. 2022. Transgenic manipulation of triacylglycerol biosynthetic enzymes in B. napus alters lipid-associated gene expression and lipid metabolism. Scientific Reports 12(1), article number: 3352. (10.1038/s41598-022-07387-x)
2021
- Guschina, I. A. and Harwood, J. L. 2021. Chemical diversity of lipids. In: Encyclopedia of Biophysics. Springer, (10.1007/978-3-642-35943-9_526-1)
2020
- Harwood, J. L. 2020. Working with Randy: the diacylglycerol acyltransferase story. Lipids 55(5), pp. 419-423. (10.1002/lipd.12267)
- Harwood, J. L. and Lloyd-Evans, E. eds. 2020. Essays in biochemistry volume 64, issue 3: lipid mediators. Portland Press.
- Christie, W. and Harwood, J. L. 2020. Oxidation of polyunsaturated fatty acids to produce lipid mediators. Essays in Biochemistry 64(3), pp. 401-421. (10.1042/EBC20190082)
- Amiruddin, N. et al. 2020. Characterization of oil palm Acyl-CoA-Binding proteins and correlation of their gene expression with oil synthesis. Plant and Cell Physiology 61(4), pp. 735-747. (10.1093/pcp/pcz237)
2019
- Liao, P., Woodfield, H. K., Harwood, J. L., Chye, M. and Scofield, S. 2019. Comparative transcriptomics analysis of Brassica napus L. during seed maturation reveals dynamic changes in gene expression between embryos and seed coats and distinct expression profiles of Acyl-CoA-binding proteins for lipid accumulation. Plant and Cell Physiology 60(12), pp. 2812-2825. (10.1093/pcp/pcz169)
- Woodfield, H. K. et al. 2019. Increase in lysophosphatidate acyltransferase activity in oilseed rape (Brassica napus) increases seed triacylglycerol content despite its low intrinsic flux control coefficient. New Phytologist 224(2), pp. 700-711. (10.1111/nph.16100)
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)
- Balogi, Z. et al. 2019. Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. Progress in Lipid Research 74, pp. 18-30. (10.1016/j.plipres.2019.01.004)
- Li-Beisson, Y., Thelen, J. J., Fedosejevs, E. and Harwood, J. L. 2019. The lipid biochemistry of eukaryotic algae. Progress in Lipid Research 74, pp. 31-68. (10.1016/j.plipres.2019.01.003)
- Harwood, J. 2019. Algae: critical sources of very long-chain polyunsaturated fatty acids. Biomolecules 9(11), article number: 708. (10.3390/biom9110708)
2018
- Guschina, I. A. and Harwood, J. L. 2018. Strategies for the analysis of plant lipids. In: Encyclopedia of Analytical Chemistry. John Wiley & Sons, Ltd., (10.1002/9780470027318.a9920.pub2)
- Rosli, R. et al. 2018. In silico characterization and expression profiling of the diacylglycerol acyltransferase gene family (DGAT1, DGAT2, DGAT3 and WS/DGAT) from oil palm, Elaeis guineensis. Plant Science 275, pp. 84-96. (10.1016/j.plantsci.2018.07.011)
- Pope, I. et al. 2018. Coherent Raman Scattering microscopy: technology developments and biological applications. Presented at: 20th International Conference on Transparent Optical Networks (ICTON), Bucharest, Romania, 1-5 Jul 201820th International Conference on Transparent Optical Networks (ICTON). IEEE, (10.1109/ICTON.2018.8473706)
- Woodfield, H. K., Cazenave-Gassiot, A., Haslam, R. P., Guschina, I. A., Wenk, M. R. and Harwood, J. L. 2018. Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.). Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(3) (10.1016/j.bbalip.2017.12.010)
2017
- Kendall, A. C., Kiezel-Tsugunova, M., Brownbridge, L. C., Harwood, J. L. and Nicolaou, A. 2017. Lipid functions in skin: differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859(9b), pp. 1679-1689. (10.1016/j.bbamem.2017.03.016)
- Harwood, J. L., Woodfield, H. K., Chen, G. and Weselake, R. J. 2017. Modification of oil crops to produce fatty acids for industrial applications. In: Ahmad, M. U. ed. Fatty Acids Chemistry, Synthesis, and Applications. Elsevier, pp. 187-236., (10.1016/B978-0-12-809521-8.00005-2)
- Woodfield, H. K., Sturtevant, D., Borisjuk, L., Munz, E., Guschina, I. A., Chapman, K. and Harwood, J. L. 2017. Spatial and temporal mapping of key lipid species in Brassica napus seeds. Plant Physiology 173(4), pp. 1998-2009. (10.1104/pp.16.01705)
- Harwood, J. L. 2017. Inspired by lipids: the Morton Lecture Award Presentation. Biochemical Society Transactions 45(2), pp. 297-302. (10.1042/BST20160406)
- Weselake, R. J., Woodfield, H. K., Field, C. J. and Harwood, J. L. 2017. Production of edible oils through metabolic engineering. In: Food Lipids Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press, pp. 973.
- Harwood, J. and Price-Jones, M. J. 2017. Phosphatidate phosphohydrolase in plants and microorganisms. In: Phosphatidate Phosphohydrolase. CRC Press, pp. 1-37.
- Hall, J. H. and Harwood, J. L. 2017. Brain lipids in health and disease. In: Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press, pp. 747-764.
2016
- Harwood, J. L. 2016. Research with a purpose. INFORM: International News on Fats, Oils, and Related Materials 27(10), pp. 28-31.
- Woodfield, H. K. and Harwood, J. L. 2016. Oilseed crops: linseed, rapeseed, soybean, and sunflower. In: Thomas, B., Murray, B. G. and Murphy, D. J. eds. Encyclopedia of Applied Plant Sciences 2nd Edition. Elsevier, pp. 34-38., (10.1016/B978-0-12-394807-6.00212-4)
- Stokes, C. A. et al. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9(5), pp. 1303-1316. (10.1038/mi.2015.137)
- Gurr, M. L., Harwood, J. L., Frayn, K. N., Murphy, D. J. and Michell, R. H. 2016. Lipids: biochemistry, biotechnology and health, 6th Edition. UK: Wiley/Blackwell.
- Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
- Hall, J. H., Wiseman, F. K., Fisher, E. M. C., Tybulewicz, V. L. J., Harwood, J. L. and Good, M. A. 2016. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory 130, pp. 118-128. (10.1016/j.nlm.2016.02.002)
- Wacker, A., Piepho, M., Harwood, J. L., Guschina, I. and Arts, M. T. 2016. Light-induced changes in fatty acid profiles of specific lipid classes in several freshwater phytoplankton species. Frontiers in Plant Science 7, article number: 264. (10.3389/fpls.2016.00264)
- Nicolaou, A. and Harwood, J. L. 2016. Skin lipids in health and disease. Lipid Technology 28(2), pp. 36-39. (10.1002/lite.201600012)
- Bascoul-Colombo, C., Garaiova, I., Plummer, S. F., Harwood, J. L., Caterson, B. and Hughes, C. E. 2016. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1α in bovine cartilage explants. Cartilage 7(1), pp. 70-81. (10.1177/1947603515603762)
- Li-Beisson, Y., Nakamura, Y. and Harwood, J. L. 2016. Lipids: from chemical structures, biosynthesis, and analyses to industrial applications. In: Nakamura, Y. and Li-Beisson, Y. eds. Lipids in Plant and Algae Development., Vol. 86. Subcellular Biochemistry Vol. 86. Springer, pp. 1-18., (10.1007/978-3-319-25979-6_1)
2015
- Chen, G., Woodfield, H., Pan, X., Harwood, J. and Weselake, R. J. 2015. Acyl-trafficking during plant oil accumulation. Lipids 50(11), pp. 1057-1068. (10.1007/s11745-015-4069-x)
- Escribá, P. V. et al. 2015. Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Progress in Lipid Research 59, pp. 38-53. (10.1016/j.plipres.2015.04.003)
- Harwood, J. L. 2015. Inspiré par les lipides (Médaille Chevreul 2014). OCL 22(2), article number: A202. (10.1051/ocl/2015002)
- Woodfield, H., Harwood, J. L. and Weselake, R. J. 2015. Tailoring lipid synthesis in oil crops. Inform 26(2), pp. 78-83.
- Guschina, I., Everard, J. D., Kinney, A. J., Quant, P. A. and Harwood, J. L. 2015. Erratum to ‘Studies on the regulation of lipid biosynthesis in plants: Application of control analysis to soybean’ [Biochim. Biophys. Acta 1838 (2014) 1488–1500]. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848(1), pp. 104. (10.1016/j.bbamem.2014.10.011)
2014
- Harwood, J. L. 2014. Inspired by lipids (the Chevreul Award Lecture 2014). European Journal of Lipid Science and Technology 116(10), pp. 1259-1267. (10.1002/ejlt.201400021)
- Salas, J. J. et al. 2014. Biochemistry of high stearic sunflower, a new source of saturated fats. Progress in Lipid Research 55, pp. 30-42. (10.1016/j.plipres.2014.05.001)
- Guschina, I., Everard, J. D., Kinney, A. J., Quant, P. A. and Harwood, J. 2014. Studies on the regulation of lipid biosynthesis in plants: application of control analysis to soybean. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(6), pp. 1488-1500. (10.1016/j.bbamem.2014.02.008)
- Török, Z. et al. 2014. Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(6), pp. 1594-1618. (10.1016/j.bbamem.2013.12.015)
- Morris, C., Owen, J. R., Thomas, M. C., El-Hiti, G. A., Harwood, J. L. and Kille, P. 2014. Intracellular localization and induction of a dynamic RNA-editing event of macro-algal V-ATPase subunit A (VHA-A) in response to copper. Plant, Cell & Environment 37(1), pp. 189-203. (10.1111/pce.12145)
- Ramli, U. S., Tang, M., Quant, P. A., Guschina, I., Fawcett, T. and Harwood, J. L. 2014. Informed metabolic engineering of oil crops using control analysis. Biocatalysis and Agricultural Biotechnology 3(1), pp. 49-52. (10.1016/j.bcab.2013.12.001)
- Steiner, T. et al. 2014. Protective role for properdin in progression of experimental murine atherosclerosis. PLoS ONE 9(3), article number: e92404. (10.1371/journal.pone.0092404)
2013
- Harwood, J. L., Ramli, U. S., Tang, M., Quant, P. A., Weselake, R. J., Fawcett, T. and Guschina, I. 2013. Regulation and enhancement of lipid accumulation in oil crops: The use of metabolic control analysis for informed genetic manipulation. European Journal of Lipid Science and Technology 115(11), pp. 1239-1246. (10.1002/ejlt.201300257)
- Randall, J., Cable, J., Guschina, I., Harwood, J. L. and Lello, J. 2013. Endemic infection reduces transmission potential of an epidemic parasite during co-infection. Proceedings of the Royal Society B: Biological Sciences 280(1769), article number: 20131500. (10.1098/rspb.2013.1500)
- Rahman, H., Harwood, J. L. and Weselake, R. 2013. Increasing seed oil content in Brassica species through breeding and biotechnology. Lipid Technology 25(8), pp. 182-185. (10.1002/lite.201300291)
- Balogh, G. et al. 2013. Key role of lipids in heat stress management. FEBS Letters 587(13), pp. 1970-1980. (10.1016/j.febslet.2013.05.016)
- Harwood, J. L. and Guschina, I. 2013. Regulation of lipid synthesis in oil crops. FEBS Letters 587(13), pp. 2079-2081. (10.1016/j.febslet.2013.05.018)
2012
- Péter, M. et al. 2012. Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture. Molecular Membrane Biology 29(7), pp. 274-289. (10.3109/09687688.2012.680203)
- Tang, M., Guschina, I., O'Hara, P., Slabas, A. R., Quant, P. A., Fawcett, T. and Harwood, J. L. 2012. Metabolic control analysis of developing oilseed rape (Brassica napus cv Westar) embryos shows that lipid assembly exerts significant control over oil accumulation. New Phytologist 196(2), pp. 414-426. (10.1111/j.1469-8137.2012.04262.x)
- Owen, J. R., Morris, C., Nicolaus, B., Harwood, J. L. and Kille, P. 2012. Induction of expression of a 14-3-3 gene in response to copper exposure in the marine alga, Fucus vesiculosus. Ecotoxicology 21(1), pp. 124-138. (10.1007/s10646-011-0772-4)
- Falinska, A. M., Bascoul-Colombo, C., Guschina, I., Good, M. A. and Harwood, J. L. 2012. The role of n-3 dietary polyunsaturated fatty acids in brain function and ameliorating Alzheimer's disease: Opportunities for biotechnology in the development of nutraceuticals. Biocatalysis and Agricultural Biotechnology 1(2), pp. 159-166. (10.1016/j.bcab.2011.09.001)
- Horváth, I. et al. 2012. Heat shock response in photosynthetic organisms: Membrane and lipid connections. Progress in Lipid Research 51(3), pp. 208-220. (10.1016/j.plipres.2012.02.002)
- Hemmerlin, A., Harwood, J. L. and Bach, T. J. 2012. A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?. Progress in Lipid Research 51(2), pp. 95-148. (10.1016/j.plipres.2011.12.001)
- Elphick, L. M. et al. 2012. Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease Models & Mechanisms 5(2), pp. 231-240. (10.1242/dmm.008391)
2011
- McLaren, J. E., Michael, D. R., Guschina, I., Harwood, J. L. and Ramji, D. P. 2011. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46(11), pp. 1053-1061.
- Stefanoudaki, E., Koutsaftakis, A. and Harwood, J. L. 2011. Influence of malaxation conditions on characteristic qualities of olive oil. Food Chemistry 127(4), pp. 1481-1486. (10.1016/j.foodchem.2011.01.120)
- Fuschino, J., Guschina, I., Dobson, G., Yan, N., Harwood, J. L. and Arts, M. 2011. Rising water temperatures alter lipid dynamics and reduce n-3 essential fatty acid concerntrations in Scenedesmus obliquus (chlorophyta). Journal of Phycology 47(4), pp. 763-774. (10.1111/j.1529-8817.2011.01024.x)
- Harwood, J. L. 2011. Fascinating lipids: from brain to plants and soil and back to brain. International News on Fats, Oils and Related Materials 22(7), pp. 448-451.
- Balogh, G. et al. 2011. Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells. PLoS ONE 6(6), article number: e21182. (10.1371/journal.pone.0021182)
- Guschina, I., Millership, S., O'Donnell, V. B., Ninkina, N., Harwood, J. and Buchman, V. L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46(2), pp. 121-130. (10.1007/s11745-010-3486-0)
2010
- Balogh, G. et al. 2010. Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801(9), pp. 1036-1047. (10.1016/j.bbalip.2010.04.011)
- Stefanoudaki, E., Williams, M. and Harwood, J. L. 2010. Changes in virgin olive oil characteristics during different storage conditions. European Journal of Lipid Science and Technology 112(8), pp. 906-914. (10.1002/ejlt.201000066)
- Ruiz-Lopez, N., Garces, R., Harwood, J. and Martinez-Force, E. 2010. Characterization and partial purification of acyl-CoA:glycerol 3-phosphate acyltransferase from sunflower (Helianthus annuus L.) developing seeds. Plant Physiology and Biochemistry 48(2-3), pp. 73-80. (10.1016/j.plaphy.2009.12.001)
- Yang, X., Guschina, I., Hurst, S., Wood, S., Langford, M., Hawkes, T. and Harwood, J. 2010. The action of herbicides on fatty acid biosynthesis and elongation in barley and cucumber. Pest management Science 66(7), pp. 794-800. (10.1002/ps.1944)
- Hurst, S., Zainal, Z., Caterson, B., Hughes, C. E. and Harwood, J. L. 2010. Dietary fatty acids and arthritis. Prostaglandins Leukotrienes & Essential Fatty Acids 82(4-6), pp. 315-318. (10.1016/j.plefa.2010.02.008)
2009
- Ramli, U. S., Salas, J. J., Quant, P. A. and Harwood, J. L. 2009. Use of metabolic control analysis to give quantitative information on control of lipid biosynthesis in the important oil crop, Elaeis guineensis (oilpalm). New Phytologist 184(2), pp. 330-339. (10.1111/j.1469-8137.2009.02962.x)
- Harwood, J. L. 2009. Special roles for special lipids- it's not just fat. Biochemist 31(5), pp. 10-14.
- Zainal, Z., Longman, A. J., Hurst, S., Duggan, K., Caterson, B., Hughes, C. E. and Harwood, J. L. 2009. Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis and Cartilage 17(7), pp. 896-905. (10.1016/j.joca.2008.12.009)
- Hurst, S., Rees, S. G., Randerson, P. F., Caterson, B. and Harwood, J. 2009. Contrasting Effects of n-3 and n-6 Fatty Acids on Cyclooxygenase-2 in Model Systems for Arthritis. Lipids 44.(10), pp. 889-896. (10.1007/s11745-009-3347-x)
- Stefanoudaki, E., Williams, M., Chartzoulakis, K. and Harwood, J. 2009. Effect of irrigation on quality attributes of olive oil. Journal of Agricultural and Food Chemistry 57(15), pp. 7048-7055. (10.1021/jf900862w)
- Weselake, R., Taylor, D., Rahman, M., Shah, S., Laroche, A., McVetty, P. E. and Harwood, J. L. 2009. Increasing the flow of carbon into seed oil. Biotechnology Advances 27(6), pp. 866-878. (10.1016/j.biotechadv.2009.07.001)
- Balogh, G. et al. 2009. Membrane origin of stress response in B16 cells: a lipidomic approach. Chemistry and Physics of Lipids 160(S1), pp. S18-S19. (10.1016/j.chemphyslip.2009.06.003)
- Guschina, I., Harris, K. M., Maskrey, B., Goldberg, B., Lloyd, D. and Harwood, J. 2009. The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. Journal of Eukaryotic Microbiology 56(1), pp. 52-57. (10.1111/j.1550-7408.2008.00365.x)
- Taylor, D. C. et al. 2009. Molecular modification of triacylglycerol accumulation by over-expression of DGAT1 to produce canola with increased seed oil content under field conditions. Botany-Botanique 87(6), pp. 533-543. (10.1139/B08-101)
- Zainal, Z., Longman, A. J., Hurst, S., Duggan, K., Hughes, C. E., Caterson, B. and Harwood, J. 2009. Modification of Palm Oil for Anti-Inflammatory Nutraceutical Properties. Lipids 44(7), pp. 581-592. (10.1007/s11745-009-3304-8)
- Stefanoudaki, E., Williams, M., Chartzoulakis, K. and Harwood, J. 2009. Olive oil qualitative parameters after orchard irrigation with saline water. Journal of Agricultural and Food Chemistry 57(4), pp. 1421-1425. (10.1021/jf8030327)
- Harwood, J. L. and Guschina, I. 2009. The versatility of algae and their lipid metabolism. Biochimie 91(6), pp. 679-684. (10.1016/j.biochi.2008.11.004)
- Grønlund, A. L., Dickinson, J. R., Kille, P., Harwood, J. L., Herbert, R., Francis, D. and Rogers, H. J. 2009. Plant WEE1 Kinase Interacts with a 14-3-3 Protein, GF14ω but a Mutation of WEE1 at S485 Alters Their Spatial Interaction. The Open Plant Science Journal 3, pp. 40-48. (10.2174/1874294700903010040)
2008
- Jackson, S. K., Abate, W., Parton, J., Jones, S. and Harwood, J. L. 2008. Lysophospholipid metabolism facilitates Toll-like receptor 4 membrane translocation to regulate the inflammatory response. Journal of Leukocyte Biology 84(1), pp. 86-92. (10.1189/jlb.0907601)
- Williams, M. and Harwood, J. 2008. Characterisation of lipoxygenase isoforms from olive callus cultures. Phytochemistry 69(14), pp. 2532-2538. (10.1016/j.phytochem.2008.08.001)
- Hernandez, M. L., Guschina, I., Martinez-Rivas, J. M., Mancha, M. and Harwood, J. L. 2008. The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. Journal of Experimental Botany 59(9), pp. 2425-2435. (10.1093/jxb/ern121)
- Weselake, R. et al. 2008. Metabolic control analysis is helpful for informed genetic manipulation of oilseed rape (Brassica napus) to increase seed oil content. Journal of Experimental Botany 59(13), pp. 3543-3549. (10.1093/jxb/ern206)
2005
- Harwood, J., Quant, P., Ramli, U. and Salas, J. 2005. Metabolic control analysis reveals an important role for diacylglycerol acyltransferase in olive but not in oil palm lipid accumulation. FEBS Journal, pp. 5764-5770. (10.1111/j.1742-4658.2005.04964.x)
- Heard, C. M. et al. 2005. Preferential π–π complexation between tamoxifen and borage oil/γ linolenic acid: transcutaneous delivery and NMR spectral modulation. International Journal of Pharmaceutics 302(1-2), pp. 47-55. (10.1016/j.ijpharm.2005.06.013)
- Gomez-Escalada, M., Harwood, J., Maillard, J. and Ochs, D. 2005. Triclosan inhibition of fatty acid synthesis and its effect on growth of Escherichia coli and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 55(6), pp. 879-882. (10.1093/jac/dki123)
- Vigh, L. et al. 2005. The significance of lipid composition for membrane activity: New concepts and ways of assessing function. Progress in Lipid Research 44(5), pp. 303-344. (10.1016/j.plipres.2005.08.001)
- Jones, S. M., Urch, J. E., Kaiser, M., Brun, R., Harwood, J. L., Berry, C. and Gilbert, I. H. 2005. Analogues of thiolactomycin as potential antimalarial agents. Journal of Medicinal Chemistry 48(19), pp. 5932-5941. (10.1021/jm049067d)
2004
- Curtis, C., Rees, S., Evans, R., Dent, C., Caterson, B. and Harwood, J. L. 2004. The Effects of n-3 Polyunsaturated Fatty Acids on Cartilage Metabolism in Patients with Osteoarthritis: the Results of a Pilot Clinical Trial. Presented at: 3rd Euro Fed Lipid Congress, Edinburgh, Scotland, 5-8 September 2004.
- Karia, C., Harwood, J. L., Morris, A. and Heard, C. M. 2004. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. International Journal of Pharmaceutics 271(1-2), pp. 305-309. (10.1016/j.ijpharm.2003.11.017)
- Jones, S. M., Urch, J. E., Brun, R., Harwood, J. L., Berry, C. and Gilbert, I. H. 2004. Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents. Bioorganic & Medicinal Chemistry 12(4), pp. 683-692. (10.1016/j.bmc.2003.11.023)
- Curtis, C. L., Harwood, J. L., Dent, C. M. and Caterson, B. 2004. Biological basis for the benefit of nutraceutical supplementation in arthritis. Drug Discovery Today 9(4), pp. 165-172. (10.1016/S1359-6446(03)02980-5)
2003
- Roy, A. B., Hewlins, M. J. E., Ellis, A. J., Harwood, J. L. and White, G. F. 2003. Glycolytic breakdown of sulfoquinovose in bacteria: a missing link in the sulfur cycle. Applied and Environmental Microbiology 69(11), pp. 6434-6441. (10.1128/AEM.69.11.6434-6441.2003)
- Price, L. J., Herbert, D., Moss, S. R., Cole, D. J. and Harwood, J. 2003. Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase isoforms. Biochemical Journal, pp. 415-423. (10.1042/BJ20030665)
- Heard, C. M., Gallagher, S. J., Harwood, J. L. and Maguire, P. B. 2003. The in vitro delivery of NSAIDS across skin was in proportion to the delivery of essential fatty acids in the vehicle - evidence that solutes permeate skin associated with their solvation cages?. International Journal of Pharmaceutics 261(1-2), pp. 165-169. (10.1016/S0378-5173(03)00297-7)
- Roy, A. B., Hewlins, M. J. E., Ellis, A. J., Harwood, J. L. and White, G. F. 2003. Glycolytic breakdown of sulfoquinovose in bacteria: a missing link in the sulphur cycle. Applied and Environmental Microbiology 69(11), pp. 6434-6441. (10.1128/AEM.69.11.6434-6441.2003)
2002
- Rutter, A. J., Thomas, K. L., Herbert, D., Henderson, R. J., Lloyd, D. and Harwood, J. 2002. Oxygen induction of a novel fatty acid n-6 desaturase in the soil protozoon, Acanthamoeba castellanii. Biochemical Journal, pp. 57-67. (10.1042/BJ20020189)
- Ramli, U. S., Baker, D. S., Quant, P. A. and Harwood, J. 2002. Control analysis of lipid biosynthesis in tissue cultures from oil crops shows that flux control is shared between fatty acid synthesis and lipid assembly. Biochemical Journal 364, pp. 393-401. (10.1042/BJ20010203)
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2000
- Curtis, C. L., Hughes, C. E., Flannery, C. R., Little, C. B., Harwood, J. L. and Caterson, B. 2000. n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation. Journal of Biological Chemistry 275(2), pp. 721-724. (10.1074/jbc.275.2.721)
- Al-Malki, A., Morby, A. P. and Harwood, J. L. 2000. Pea choline kinase: purification, properties and isolation of a cDNA. Biochemical Society Transactions 28(6), pp. 721-723. (10.1042/0300-5127:0280721)
1999
- Perry, H. J., Bligny, R., Gout, E. and Harwood, J. L. 1999. Changes in Kennedy pathway intermediates associated with increased triacylglycerol synthesis in oil-seed rape. Phytochemistry 52(5), pp. 799-804. (10.1016/S0031-9422(99)00294-0)
Adrannau llyfrau
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- Harwood, J. and Price-Jones, M. J. 2017. Phosphatidate phosphohydrolase in plants and microorganisms. In: Phosphatidate Phosphohydrolase. CRC Press, pp. 1-37.
- Hall, J. H. and Harwood, J. L. 2017. Brain lipids in health and disease. In: Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition. CRC Press, pp. 747-764.
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Cynadleddau
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Erthyglau
- Weselake, R. J., Fell, D. A., Wang, X., Scofield, S., Chen, G. and Harwood, J. L. 2024. Increasing oil content in Brassica oilseed species. Progress in Lipid Research 96, article number: 101306. (10.1016/j.plipres.2024.101306)
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- Harwood, J. L. 2016. Research with a purpose. INFORM: International News on Fats, Oils, and Related Materials 27(10), pp. 28-31.
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- Hall, J. H., Wiseman, F. K., Fisher, E. M. C., Tybulewicz, V. L. J., Harwood, J. L. and Good, M. A. 2016. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory 130, pp. 118-128. (10.1016/j.nlm.2016.02.002)
- Wacker, A., Piepho, M., Harwood, J. L., Guschina, I. and Arts, M. T. 2016. Light-induced changes in fatty acid profiles of specific lipid classes in several freshwater phytoplankton species. Frontiers in Plant Science 7, article number: 264. (10.3389/fpls.2016.00264)
- Nicolaou, A. and Harwood, J. L. 2016. Skin lipids in health and disease. Lipid Technology 28(2), pp. 36-39. (10.1002/lite.201600012)
- Bascoul-Colombo, C., Garaiova, I., Plummer, S. F., Harwood, J. L., Caterson, B. and Hughes, C. E. 2016. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1α in bovine cartilage explants. Cartilage 7(1), pp. 70-81. (10.1177/1947603515603762)
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- Woodfield, H., Harwood, J. L. and Weselake, R. J. 2015. Tailoring lipid synthesis in oil crops. Inform 26(2), pp. 78-83.
- Guschina, I., Everard, J. D., Kinney, A. J., Quant, P. A. and Harwood, J. L. 2015. Erratum to ‘Studies on the regulation of lipid biosynthesis in plants: Application of control analysis to soybean’ [Biochim. Biophys. Acta 1838 (2014) 1488–1500]. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848(1), pp. 104. (10.1016/j.bbamem.2014.10.011)
- Harwood, J. L. 2014. Inspired by lipids (the Chevreul Award Lecture 2014). European Journal of Lipid Science and Technology 116(10), pp. 1259-1267. (10.1002/ejlt.201400021)
- Salas, J. J. et al. 2014. Biochemistry of high stearic sunflower, a new source of saturated fats. Progress in Lipid Research 55, pp. 30-42. (10.1016/j.plipres.2014.05.001)
- Guschina, I., Everard, J. D., Kinney, A. J., Quant, P. A. and Harwood, J. 2014. Studies on the regulation of lipid biosynthesis in plants: application of control analysis to soybean. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838(6), pp. 1488-1500. (10.1016/j.bbamem.2014.02.008)
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- Morris, C., Owen, J. R., Thomas, M. C., El-Hiti, G. A., Harwood, J. L. and Kille, P. 2014. Intracellular localization and induction of a dynamic RNA-editing event of macro-algal V-ATPase subunit A (VHA-A) in response to copper. Plant, Cell & Environment 37(1), pp. 189-203. (10.1111/pce.12145)
- Ramli, U. S., Tang, M., Quant, P. A., Guschina, I., Fawcett, T. and Harwood, J. L. 2014. Informed metabolic engineering of oil crops using control analysis. Biocatalysis and Agricultural Biotechnology 3(1), pp. 49-52. (10.1016/j.bcab.2013.12.001)
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- Harwood, J. L., Ramli, U. S., Tang, M., Quant, P. A., Weselake, R. J., Fawcett, T. and Guschina, I. 2013. Regulation and enhancement of lipid accumulation in oil crops: The use of metabolic control analysis for informed genetic manipulation. European Journal of Lipid Science and Technology 115(11), pp. 1239-1246. (10.1002/ejlt.201300257)
- Randall, J., Cable, J., Guschina, I., Harwood, J. L. and Lello, J. 2013. Endemic infection reduces transmission potential of an epidemic parasite during co-infection. Proceedings of the Royal Society B: Biological Sciences 280(1769), article number: 20131500. (10.1098/rspb.2013.1500)
- Rahman, H., Harwood, J. L. and Weselake, R. 2013. Increasing seed oil content in Brassica species through breeding and biotechnology. Lipid Technology 25(8), pp. 182-185. (10.1002/lite.201300291)
- Balogh, G. et al. 2013. Key role of lipids in heat stress management. FEBS Letters 587(13), pp. 1970-1980. (10.1016/j.febslet.2013.05.016)
- Harwood, J. L. and Guschina, I. 2013. Regulation of lipid synthesis in oil crops. FEBS Letters 587(13), pp. 2079-2081. (10.1016/j.febslet.2013.05.018)
- Péter, M. et al. 2012. Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture. Molecular Membrane Biology 29(7), pp. 274-289. (10.3109/09687688.2012.680203)
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- Owen, J. R., Morris, C., Nicolaus, B., Harwood, J. L. and Kille, P. 2012. Induction of expression of a 14-3-3 gene in response to copper exposure in the marine alga, Fucus vesiculosus. Ecotoxicology 21(1), pp. 124-138. (10.1007/s10646-011-0772-4)
- Falinska, A. M., Bascoul-Colombo, C., Guschina, I., Good, M. A. and Harwood, J. L. 2012. The role of n-3 dietary polyunsaturated fatty acids in brain function and ameliorating Alzheimer's disease: Opportunities for biotechnology in the development of nutraceuticals. Biocatalysis and Agricultural Biotechnology 1(2), pp. 159-166. (10.1016/j.bcab.2011.09.001)
- Horváth, I. et al. 2012. Heat shock response in photosynthetic organisms: Membrane and lipid connections. Progress in Lipid Research 51(3), pp. 208-220. (10.1016/j.plipres.2012.02.002)
- Hemmerlin, A., Harwood, J. L. and Bach, T. J. 2012. A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?. Progress in Lipid Research 51(2), pp. 95-148. (10.1016/j.plipres.2011.12.001)
- Elphick, L. M. et al. 2012. Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Disease Models & Mechanisms 5(2), pp. 231-240. (10.1242/dmm.008391)
- McLaren, J. E., Michael, D. R., Guschina, I., Harwood, J. L. and Ramji, D. P. 2011. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46(11), pp. 1053-1061.
- Stefanoudaki, E., Koutsaftakis, A. and Harwood, J. L. 2011. Influence of malaxation conditions on characteristic qualities of olive oil. Food Chemistry 127(4), pp. 1481-1486. (10.1016/j.foodchem.2011.01.120)
- Fuschino, J., Guschina, I., Dobson, G., Yan, N., Harwood, J. L. and Arts, M. 2011. Rising water temperatures alter lipid dynamics and reduce n-3 essential fatty acid concerntrations in Scenedesmus obliquus (chlorophyta). Journal of Phycology 47(4), pp. 763-774. (10.1111/j.1529-8817.2011.01024.x)
- Harwood, J. L. 2011. Fascinating lipids: from brain to plants and soil and back to brain. International News on Fats, Oils and Related Materials 22(7), pp. 448-451.
- Balogh, G. et al. 2011. Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells. PLoS ONE 6(6), article number: e21182. (10.1371/journal.pone.0021182)
- Guschina, I., Millership, S., O'Donnell, V. B., Ninkina, N., Harwood, J. and Buchman, V. L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46(2), pp. 121-130. (10.1007/s11745-010-3486-0)
- Balogh, G. et al. 2010. Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801(9), pp. 1036-1047. (10.1016/j.bbalip.2010.04.011)
- Stefanoudaki, E., Williams, M. and Harwood, J. L. 2010. Changes in virgin olive oil characteristics during different storage conditions. European Journal of Lipid Science and Technology 112(8), pp. 906-914. (10.1002/ejlt.201000066)
- Ruiz-Lopez, N., Garces, R., Harwood, J. and Martinez-Force, E. 2010. Characterization and partial purification of acyl-CoA:glycerol 3-phosphate acyltransferase from sunflower (Helianthus annuus L.) developing seeds. Plant Physiology and Biochemistry 48(2-3), pp. 73-80. (10.1016/j.plaphy.2009.12.001)
- Yang, X., Guschina, I., Hurst, S., Wood, S., Langford, M., Hawkes, T. and Harwood, J. 2010. The action of herbicides on fatty acid biosynthesis and elongation in barley and cucumber. Pest management Science 66(7), pp. 794-800. (10.1002/ps.1944)
- Hurst, S., Zainal, Z., Caterson, B., Hughes, C. E. and Harwood, J. L. 2010. Dietary fatty acids and arthritis. Prostaglandins Leukotrienes & Essential Fatty Acids 82(4-6), pp. 315-318. (10.1016/j.plefa.2010.02.008)
- Ramli, U. S., Salas, J. J., Quant, P. A. and Harwood, J. L. 2009. Use of metabolic control analysis to give quantitative information on control of lipid biosynthesis in the important oil crop, Elaeis guineensis (oilpalm). New Phytologist 184(2), pp. 330-339. (10.1111/j.1469-8137.2009.02962.x)
- Harwood, J. L. 2009. Special roles for special lipids- it's not just fat. Biochemist 31(5), pp. 10-14.
- Zainal, Z., Longman, A. J., Hurst, S., Duggan, K., Caterson, B., Hughes, C. E. and Harwood, J. L. 2009. Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis and Cartilage 17(7), pp. 896-905. (10.1016/j.joca.2008.12.009)
- Hurst, S., Rees, S. G., Randerson, P. F., Caterson, B. and Harwood, J. 2009. Contrasting Effects of n-3 and n-6 Fatty Acids on Cyclooxygenase-2 in Model Systems for Arthritis. Lipids 44.(10), pp. 889-896. (10.1007/s11745-009-3347-x)
- Stefanoudaki, E., Williams, M., Chartzoulakis, K. and Harwood, J. 2009. Effect of irrigation on quality attributes of olive oil. Journal of Agricultural and Food Chemistry 57(15), pp. 7048-7055. (10.1021/jf900862w)
- Weselake, R., Taylor, D., Rahman, M., Shah, S., Laroche, A., McVetty, P. E. and Harwood, J. L. 2009. Increasing the flow of carbon into seed oil. Biotechnology Advances 27(6), pp. 866-878. (10.1016/j.biotechadv.2009.07.001)
- Balogh, G. et al. 2009. Membrane origin of stress response in B16 cells: a lipidomic approach. Chemistry and Physics of Lipids 160(S1), pp. S18-S19. (10.1016/j.chemphyslip.2009.06.003)
- Guschina, I., Harris, K. M., Maskrey, B., Goldberg, B., Lloyd, D. and Harwood, J. 2009. The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. Journal of Eukaryotic Microbiology 56(1), pp. 52-57. (10.1111/j.1550-7408.2008.00365.x)
- Taylor, D. C. et al. 2009. Molecular modification of triacylglycerol accumulation by over-expression of DGAT1 to produce canola with increased seed oil content under field conditions. Botany-Botanique 87(6), pp. 533-543. (10.1139/B08-101)
- Zainal, Z., Longman, A. J., Hurst, S., Duggan, K., Hughes, C. E., Caterson, B. and Harwood, J. 2009. Modification of Palm Oil for Anti-Inflammatory Nutraceutical Properties. Lipids 44(7), pp. 581-592. (10.1007/s11745-009-3304-8)
- Stefanoudaki, E., Williams, M., Chartzoulakis, K. and Harwood, J. 2009. Olive oil qualitative parameters after orchard irrigation with saline water. Journal of Agricultural and Food Chemistry 57(4), pp. 1421-1425. (10.1021/jf8030327)
- Harwood, J. L. and Guschina, I. 2009. The versatility of algae and their lipid metabolism. Biochimie 91(6), pp. 679-684. (10.1016/j.biochi.2008.11.004)
- Grønlund, A. L., Dickinson, J. R., Kille, P., Harwood, J. L., Herbert, R., Francis, D. and Rogers, H. J. 2009. Plant WEE1 Kinase Interacts with a 14-3-3 Protein, GF14ω but a Mutation of WEE1 at S485 Alters Their Spatial Interaction. The Open Plant Science Journal 3, pp. 40-48. (10.2174/1874294700903010040)
- Jackson, S. K., Abate, W., Parton, J., Jones, S. and Harwood, J. L. 2008. Lysophospholipid metabolism facilitates Toll-like receptor 4 membrane translocation to regulate the inflammatory response. Journal of Leukocyte Biology 84(1), pp. 86-92. (10.1189/jlb.0907601)
- Williams, M. and Harwood, J. 2008. Characterisation of lipoxygenase isoforms from olive callus cultures. Phytochemistry 69(14), pp. 2532-2538. (10.1016/j.phytochem.2008.08.001)
- Hernandez, M. L., Guschina, I., Martinez-Rivas, J. M., Mancha, M. and Harwood, J. L. 2008. The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. Journal of Experimental Botany 59(9), pp. 2425-2435. (10.1093/jxb/ern121)
- Weselake, R. et al. 2008. Metabolic control analysis is helpful for informed genetic manipulation of oilseed rape (Brassica napus) to increase seed oil content. Journal of Experimental Botany 59(13), pp. 3543-3549. (10.1093/jxb/ern206)
- Harwood, J., Quant, P., Ramli, U. and Salas, J. 2005. Metabolic control analysis reveals an important role for diacylglycerol acyltransferase in olive but not in oil palm lipid accumulation. FEBS Journal, pp. 5764-5770. (10.1111/j.1742-4658.2005.04964.x)
- Heard, C. M. et al. 2005. Preferential π–π complexation between tamoxifen and borage oil/γ linolenic acid: transcutaneous delivery and NMR spectral modulation. International Journal of Pharmaceutics 302(1-2), pp. 47-55. (10.1016/j.ijpharm.2005.06.013)
- Gomez-Escalada, M., Harwood, J., Maillard, J. and Ochs, D. 2005. Triclosan inhibition of fatty acid synthesis and its effect on growth of Escherichia coli and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 55(6), pp. 879-882. (10.1093/jac/dki123)
- Vigh, L. et al. 2005. The significance of lipid composition for membrane activity: New concepts and ways of assessing function. Progress in Lipid Research 44(5), pp. 303-344. (10.1016/j.plipres.2005.08.001)
- Jones, S. M., Urch, J. E., Kaiser, M., Brun, R., Harwood, J. L., Berry, C. and Gilbert, I. H. 2005. Analogues of thiolactomycin as potential antimalarial agents. Journal of Medicinal Chemistry 48(19), pp. 5932-5941. (10.1021/jm049067d)
- Karia, C., Harwood, J. L., Morris, A. and Heard, C. M. 2004. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. International Journal of Pharmaceutics 271(1-2), pp. 305-309. (10.1016/j.ijpharm.2003.11.017)
- Jones, S. M., Urch, J. E., Brun, R., Harwood, J. L., Berry, C. and Gilbert, I. H. 2004. Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents. Bioorganic & Medicinal Chemistry 12(4), pp. 683-692. (10.1016/j.bmc.2003.11.023)
- Curtis, C. L., Harwood, J. L., Dent, C. M. and Caterson, B. 2004. Biological basis for the benefit of nutraceutical supplementation in arthritis. Drug Discovery Today 9(4), pp. 165-172. (10.1016/S1359-6446(03)02980-5)
- Roy, A. B., Hewlins, M. J. E., Ellis, A. J., Harwood, J. L. and White, G. F. 2003. Glycolytic breakdown of sulfoquinovose in bacteria: a missing link in the sulfur cycle. Applied and Environmental Microbiology 69(11), pp. 6434-6441. (10.1128/AEM.69.11.6434-6441.2003)
- Price, L. J., Herbert, D., Moss, S. R., Cole, D. J. and Harwood, J. 2003. Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase isoforms. Biochemical Journal, pp. 415-423. (10.1042/BJ20030665)
- Heard, C. M., Gallagher, S. J., Harwood, J. L. and Maguire, P. B. 2003. The in vitro delivery of NSAIDS across skin was in proportion to the delivery of essential fatty acids in the vehicle - evidence that solutes permeate skin associated with their solvation cages?. International Journal of Pharmaceutics 261(1-2), pp. 165-169. (10.1016/S0378-5173(03)00297-7)
- Roy, A. B., Hewlins, M. J. E., Ellis, A. J., Harwood, J. L. and White, G. F. 2003. Glycolytic breakdown of sulfoquinovose in bacteria: a missing link in the sulphur cycle. Applied and Environmental Microbiology 69(11), pp. 6434-6441. (10.1128/AEM.69.11.6434-6441.2003)
- Rutter, A. J., Thomas, K. L., Herbert, D., Henderson, R. J., Lloyd, D. and Harwood, J. 2002. Oxygen induction of a novel fatty acid n-6 desaturase in the soil protozoon, Acanthamoeba castellanii. Biochemical Journal, pp. 57-67. (10.1042/BJ20020189)
- Ramli, U. S., Baker, D. S., Quant, P. A. and Harwood, J. 2002. Control analysis of lipid biosynthesis in tissue cultures from oil crops shows that flux control is shared between fatty acid synthesis and lipid assembly. Biochemical Journal 364, pp. 393-401. (10.1042/BJ20010203)
- Curtis, C. L. et al. 2002. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids [RETRACTED]. Arthritis & Rheumatism 46(6), pp. 1544-1553. (10.1002/art.10305)
- Curtis, C. L. et al. 2002. Effects of n-3 fatty acids on cartilage metabolism [RETRACTED]. Proceedings of the Nutrition Society 61(3), pp. 381-389. (10.1079/PNS2002174)
- Curtis, C. L., Hughes, C. E., Flannery, C. R., Little, C. B., Harwood, J. L. and Caterson, B. 2000. n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation. Journal of Biological Chemistry 275(2), pp. 721-724. (10.1074/jbc.275.2.721)
- Al-Malki, A., Morby, A. P. and Harwood, J. L. 2000. Pea choline kinase: purification, properties and isolation of a cDNA. Biochemical Society Transactions 28(6), pp. 721-723. (10.1042/0300-5127:0280721)
- Perry, H. J., Bligny, R., Gout, E. and Harwood, J. L. 1999. Changes in Kennedy pathway intermediates associated with increased triacylglycerol synthesis in oil-seed rape. Phytochemistry 52(5), pp. 799-804. (10.1016/S0031-9422(99)00294-0)
Llyfrau
- Harwood, J. L. and Lloyd-Evans, E. eds. 2020. Essays in biochemistry volume 64, issue 3: lipid mediators. Portland Press.
- Gurr, M. L., Harwood, J. L., Frayn, K. N., Murphy, D. J. and Michell, R. H. 2016. Lipids: biochemistry, biotechnology and health, 6th Edition. UK: Wiley/Blackwell.
Ymchwil
Metaboledd a Swyddogaeth Lipidau Acyl
Straen amgylcheddol a metaboledd lipid
Mae ymchwil yn cynnwys ystod eang o ffactorau amgylcheddol ac organebau targed yn amrywio o ficrobau i blanhigion uwch.
Canfuwyd bod yr Effaith Tŷ Gwydr (CO2 a thymheredd atmosfferig uwch) yn newid metaboledd lipid, yn unol â'i weithred wrth ysgogi biogenesis bilen a thwf. Gellir esbonio'r newidiadau mewn metaboledd trwy fynegiant newidiol o ddau ensym allweddol sydd bellach yn cael eu profi'n uniongyrchol. Yn gysylltiedig â'r gwaith hwn mae arbrofion ar addasu tymheredd yn y protozoon pridd pwysig, Acathamoeba castellanii. Mae effeithiau tymheredd isel wedi'u gwahanu oddi wrth effeithiau ocsigen wrth gymell mynegiant o ddirwasgiad asid brasterog n-6 sy'n gwneud y lipidau bilen yn fwy 'hylif' ac yn caniatáu ffagocytosis, a fyddai fel arall yn stopio ar dymheredd isel.
Mae rheoleiddwyr twf planhigion, fel auxins, yn ysgogi biosynthesis lipid bilen mewn pys ac rydym wedi astudio rheolaeth ffurfio ffosffatidylcholine. Mae pwynt rheoli pwysig ar lefel cytidylyltransferase ac rydym wedi astudio ei reoleiddio yn ogystal ag ynysu ei genyn. Yn fwy diweddar, rydym wedi ynysu'r genyn ar gyfer colin kinase ac wedi puro ac astudio'r ensym. Cyfansoddyn bilen planhigion pwysig arall yw'r sylffolipid. Rydym wedi egluro ei lwybr biosynthetig a'i ddiraddiad. Mae'r olaf yn bwysig ar gyfer ail-feicio sylffwr sy'n gorfod digwydd bob hydref (Fall) wrth i ddail gael eu diraddio. Mae'r broses yn cynnwys llwybr ffug-glycolytig gan ddefnyddio bacteria pridd.
Mae sawl dosbarth o blaladdwyr yn gweithredu trwy eu dylanwad ar metaboledd lipid. Rydym wedi astudio sawl ffwng sy'n lladd ffyngau planhigion (malltod tatws, llwydni) ac sy'n ymddangos fel pe baent yn newid metaboledd lipid. Mae astudiaethau hirsefydlog hefyd yn ymwneud â thiocarbamates (dosbarth chwynladdwr sy'n effeithiol trwy atal elongation asid brasterog ac, felly, ffurfiant haen wyneb) a graminicides.
Mae diddordeb cynyddol yn effeithiau gwenwynig metelau trwm. Rydym wedi dangos bod metelau o'r fath yn ymyrryd â metaboledd lipid ar wahanol lefelau mewn algâu morol, bryoffytau a chennau. Mae rhai bryoffytau braidd yn gwrthsefyll her plwm neu gopr a gellir eu datblygu ar gyfer bioadfer. O algâu brown, rydym wedi gallu ynysu metallothionein sy'n bwysig ar gyfer homeostasis metel arferol.
Rheoleiddio synthesis lipid mewn cnydau olew
Mae cnydau olew yn cynhyrchu tua 135 miliwn tunnell o gynnyrch, sy'n werth tua 115 biliwn US $ bob blwyddyn. Mewn termau meintiol palmwydd olew yw'r pwysicaf (cyfanswm o tua 25%), ffa soia yr ail (cyfanswm o 22%) a threisio hadau olew y trydydd (cyfanswm o 13% o olew). Mae angen amlwg i gynhyrchu mwy o olew, nid yn unig ar gyfer defnyddiau bwytadwy ond hefyd fel porthiant cemegol adnewyddadwy. Ar ben hynny, mae deall sut mae ansawdd yn cael ei reoli hefyd yn bwysig. Ni oedd y labordy cyntaf i gymhwyso'r dechneg o ddadansoddi rheoli fflwcs i synthesis lipid ac ers hynny rydym wedi ei ddefnyddio i archwilio rheolaeth fetabolig mewn cnydau pwysig fel palmwydd olew, ffa soia, had trais rhywiol ac olewydd.
Mewn palmwydd olew mae'r prif reolaeth yn cael ei weithredu gan gyflenwi asidau brasterog. Felly, dylid canolbwyntio ymdrechion i gynyddu cynnyrch olew mewn llinellau palmwydd olew sydd â chyfraddau uwch o synthesis asid brasterog. Er bod palmwydd olew 5 - 10 gwaith mor gynhyrchiol â chnydau olew eraill (fesul hectar), mae potensial o hyd i gynyddu ei gynnyrch 2 - 3 plygu. Byddai hyn o fudd mawr i'r byd.
Brassica napus (rape hadau olew) yw'r prif gnwd olew yng Ngogledd Ewrop a Chanada. Mae'r rhan fwyaf o blanhigfeydd yn defnyddio'r mathau isel o ddŵr sy'n addas ar gyfer olewau bwytadwy. Wrth astudio rheoleiddio cronni olew yn B. napus , gwnaethom ragweld y byddai llinellau â diacylglycerol acyltransferase uwch (DGAT) yn cynhyrchu mwy o olew. Dangoswyd bod llinellau trawsgenig gyda gweithgaredd DGAT uchel yn cynhyrchu 8% o gynnyrch cynyddol yn gyson ac yn fwy cadarn mewn amodau sychder. Rydym nawr yn edrych i weld sut y gellir cael cynnydd pellach mewn cynnyrch.
Biocemeg lipid ac agweddau meddygol
Mae nifer o brosiectau yn y labordy. yn archwilio rôl lipidau acyl mewn problemau meddygol.
Mae ysgytwad yr ysgyfaint, sy'n cael ei secretu'n barhaus i'r alfeoli, yn atal cwymp yr ysgyfaint ar anadlu allan (diwedd dod i ben). Nid yw babanod cynamserol yn gwneud syrffactydd ac, felly, gallant ddioddef o drallod anadlol. Roeddem yn un o'r labordai cyntaf i ddylunio a phrofi syrffactydd artiffisial – mae cymysgeddau o'r fath mor llwyddiannus nes eu bod yn cael eu defnyddio'n rheolaidd y dyddiau hyn. Aethom ymlaen i ddangos sut y gall metaboledd syrffactydd gael ei ddylanwadu'n sylweddol gan lwch (e.e. silica) anadlu a pin pwyntiodd y mecanwaith moleciwlaidd. Mae secretion tebyg sy'n llawn ffosffolipidau hefyd yn cael ei ffurfio yn y ceudod peritoneal lle mae ei effeithlonrwydd yn gysylltiedig â phroblemau gyda dialysis arennol ac adweithiau llidiol sy'n gysylltiedig â adlyniadau llawfeddygol.
Mae llid hefyd yn chwarae rhan mewn sioc endotoxic — adwaith acíwt gan rai cleifion i heintiau bacteriol negyddol gram yn dilyn llawdriniaeth. Rydym wedi dod o hyd i gydberthynas rhwng metaboledd asidau brasterog amlannirlawn mewn lipidau pilen penodol a rhagddodiad i sioc endotoxic. Dilynwyd y darganfyddiad hwn gan nodi acyltransferases penodol a all gyfryngu'r newidiadau mewn metaboledd. Astudiwyd un o'r ensymau hyn yn fanwl a nodwyd ei genyn. Yn ddiddorol, mae'n dangos newidiadau mewn lleoleiddio celloedd yn ystod ysgogiad cytokine.
Mae arthritis yn glefyd eang sy'n achosi llawer o ddioddefaint ac sy'n cael ei gyfryngu trwy lid gormodol a chronig. Rydym wedi bod yn astudio'r mecanweithiau moleciwlaidd y tu ôl i'r rhyddhad a ddarperir gan ddeietau olew pysgod sy'n gyfoethog mewn asidau brasterog amlannirlawn n-3 (PUFA). Gall asidau o'r fath (ond nid mathau eraill o asidau annirlawn neu dirlawn) leihau mynegiant o cytocinau llidiol ac eicosanoidau a gweithgaredd cartilag - gan ddiraddio proteinases mewn diwylliannau chondrocyte gwartheg. Yn ogystal, rydym yn treiddio'r llwybrau signalau sy'n sail i'r effeithiau ar drawsgrifio. Rydym wedi ymestyn y canlyniadau cyffrous hyn i dreialon clinigol yn ogystal ag arddangosiadau bod PUFAs dietegol n-3 yn effeithiol iawn mewn bwyd cŵn, yn enwedig ar gyfer bridiau sy'n dueddol o arthritis. Maent bellach yn cael eu defnyddio mewn llawer o frandiau perchnogol.
Mae clefydau eraill sydd â llid cronig fel ffactor sylfaenol pwysig yn cynnwys clefyd cardiofasgwlaidd (CVD) a dementia. Ar gyfer CVD, gellir dangos bod PUFAs n-3 o fudd i unigolion sydd mewn perygl o glefyd y galon. Rydym wedi dangos eu bod yn lleihau'r defnydd o lipoprotein dwysedd isel gan macrophages ac, felly, gallent leihau ffurfiant celloedd ewyn. PUFA arall (dietegol) o fudd posibl yw asid dihomogama-linolenig (DGLA) sydd, er bod pufa n-6, yn cael ei drawsnewid yn gynhyrchion gwrthlidiol ac yn lleihau llid mewn macroffagau.
Gyda disgwyliad oes cynyddol, mae dementia yn dod yn fwy a mwy cyffredin. Mae clefyd Alzheimer (AD) yn cyfrif am oddeutu 70% o gyfanswm yr achosion o ddementia ac mae'n costio dros £25 biliwn y flwyddyn i'r DU. Gellir lleihau'r llid sy'n gysylltiedig ag AD yn sylweddol gan ymyrraeth ddeietegol (olew pysgod neu pufa n-3). Mae hyn yn arwain at lai o ddyddodion beta-amyloid ac ymddygiad gwybyddol gwell. Yn ddiddorol, mae'r docosahexaenate ymennydd cynyddol (DHA) yn ddetholus ar gyfer y ffosffoglyceridau ethanolamine sydd wedi'u cysylltu ag AD.
Anrhydeddau a Gwobrau
| 2016 | Gwobr Stephen S Chang (Cymdeithas Cemegwyr Olew America) am gyflawniadau pendant mewn ymchwil ar gyfer gwella neu ddatblygu cynhyrchion sy'n gysylltiedig â lipidau |
| 2016 | Gwobr Darlith Morton (Biochem. Soc.) |
| 2014 | Dyfarnwyd Medal Chevreul (Soc. Francaise Etudes Lipides, SFEL) |
| 2014 | Etholwyd yn Gymrawd Cymdeithas Cemegwyr Olew America |
| 2014 | Penodwyd yn aelod rhyngwladol OTKA (Hwngari) |
| 2013 | Etholwyd yn Gymrawd Sefydliad Biocatalysis a Biotechnoleg Amaethyddol 2013 |
| 2012 | Gwahoddiad i fod yn Gyd-olygydd y Llyfrgell Lipid (prif ffynhonnell wybodaeth ar-lein am lipidau) |
| 2011 | Cymrawd Etholedig Cymdeithas Ddysgedig Cymru |
| 2011 | Gwobr Ymchwil AOCS Supelco/Nicholas Pelick am ymchwil wreiddiol mewn cemeg lipid |
| 2010 | Etholwyd yn Aelod Anrhydeddus o Academi Gwyddorau Hwngari |
| 2010 | Gwobrau Elsevier Y rhan fwyaf o erthyglau a lawrlwythwyd yn 2009 oedd Guschina and Harwood (2006) a Harwood and Guschina (2009), yn eu cyfnodolion priodol. |
| 2006 | Gwobr Papur a ddyfynnwyd fwyaf gan Elsevier am waith ar wrth-malarials newydd (Jones et al. 2004) |
| 2002 | Darlithydd Sefydliad Treftadaeth (Alberta, Canada) |
| 2002, 2005, 2009 | Gwobrau cyhoeddi gorau MPOB am bapurau gan Ph.D. myfyriwr, Umi Ramli, ar reoli fflwcs. (Ramli et al., 2002a, b, 2005, 2009) |
| 2001 | Clare Curtis (myfyriwr PhD) wedi derbyn Gwobr Anrhydedd Arbennig i Fyfyrwyr |
| 2000 | Gwobr Papur Maeth Gorau AOCS (Salas et al.,1999) |
| 1999 | Gwobr Ryngwladol (International Society for Fats and Oils ISF) |
| 1998 | Medal Terry Galliard am biocemeg lipid planhigion (ISPL) |
| 1998 | Gwobr Kunio Yagi (PIPAC) |
| 1997 | Gwyddonydd Ymweld y Gymdeithas Frenhinol, Rwsia |
| 1994 | Darlith Gwyddoniaeth Israddedig, Coleg Imperial Llundain |
| 1992 | Darlith Fotaneg Arbennig, Prifysgol Bryste |
| 1990 | Gwobr Cymdeithas Ffytochemistry Ewrop am 'ymchwil ragorol mewn ffytocemeg gan wyddonydd Ewropeaidd iau' |
| 1986 | British Council Visiting Scientist, Japan |
| 1979 | D.Sc. (Prifysgol Birmingham) 'Metaboledd a swyddogaeth lipidau acyl' |
Grantiau
Gwaith diweddar yn y labordy. Cyllidwyd gan yr EPSRC, nerc, BBSRC, Ymddiriedolaeth Wellcome, Ymddiriedolaeth Ymchwil Alzheimer a'r CE.
Fe'i cefnogwyd hefyd gan gydweithrediadau diwydiannol gydag AgrEvo, Arcadia, DSM, DuPont, Johnson a Johnson, MPOB, Obsidian, Rhône-Poulenc a Syngenta.
Partneriaethau cyfredol (allanol)
- Kent Chapman (Prifysgol Gogledd Texas)
- Me-Len Chye (Prifysgol Hong Kong)
- Gary Dobson (Scottish Crop Research Inst., Dundee)
- Tony Fawcett (Prifysgol Durham)
- David Fell (Oxford Brooks University)
- Tony Kinney (DuPont, Wilmington)
- Enrique Martinez-Force (Instituto de la Grasa, Seville)
- Johnathan Napier (Rothamsted Research, Herts)
- Umi Ramli (Bwrdd olew palmwydd Malaysia)
- Laszlo Vigh (Academi Gwyddorau Hwngari, Szeged)
- Markus Wenk (Prifysgol Genedlaethol Singapore)
- Randall Weselake (Prifysgol Alberta, Edmonton)
Gwyddonwyr cysylltiedig (Caerdydd)
Ysgol y Biowyddorau
- Valerie O'Donnell (Ysgol Meddygaeth)
- Mark Good (Ysgol Seicoleg)
Myfyrwyr PhD
Bywgraffiad
- B.Sc. (1966) Ph.D (1969) DSc. (1979) Prifysgol Birmingham
- Ôl-ddoethurol. yng Nghaliffornia (gyda Paul Stumpf) a Leeds (gyda Don Robinson)
- Darlithydd yng Nghaerdydd 1973, darllenydd 1980, athro 1984
- Cyfarwyddwr a Phennaeth Ysgol y Biowyddorau, Prifysgol Caerdydd 2004-10
- Dirprwy Gyfarwyddwr, Ysgol y Biowyddorau, 2010-2015
- Athro Biocemeg Lipid, Ysgol y Biowyddorau, 2015-
Dros 640 o gyhoeddiadau gwyddonol gan gynnwys 5 llyfr a 14 o gyfrolau wedi'u golygu. Mae'r llyfrau yn cynnwys Lipidau: biocemeg, biotechnoleg ac iechyd ( Gurr, M.I. et al., chweched argraffiad, 2016, Wiley-Blackwell) sef y testun myfyrwyr datblygedig diffiniol ar lipidau. Rwyf wedi bod yn gyd-awdur ar y tri argraffiad diwethaf. Golygais Handbook of Olive Oil ( R. Aparicio and J.Harwood, ail argraffiad, 2013, Springer ) sydd wedi cael dau argraffiad a chyfieithiad i'r Sbaeneg. Dyma'r prif gyfrol gyfeirio awdurdodol ar olew olewydd. Rwyf hefyd wedi bod yn gyd-olygydd pob un o'r tri argraffiad o The Lipid Handbook, y prif waith cyfeirio ar lipidau ( Gunstone, FD, Harwood, J.L. a Dijkstra, A.J., eds.,trydydd argraffiad, 2007, Gwasg CRC ). Roeddwn hefyd yn Gyd-olygydd yn Bennaeth Llyfrgell Lipid AOCS (2011-2016), prif ffynhonnell wybodaeth ar-lein ar lipidau.
Rhai anrhydeddau, gwobrau
- 1990 Gwobr Phytochemistry Soc. of Europe – ymchwil rhagorol gan wyddonydd Ewropeaidd iau
- 1998 Gwobr Kunio Yagi
- 1998 Medal Terry Galliard am biocemeg lipid planhigion
- Gwobr Ryngwladol 1999 (International Soc. for Fats and Oils)
- 2010 Etholwyd yn Aelod o Academi Gwyddorau Hwngari
- Gwobr Ymchwil AOCS Supelco/Nicholas Pelick 2011 – ymchwil gwreiddiol mewn cemeg lipid
- 2011 Etholwyd yn Gymrawd Cymdeithas Ddysgedig Cymru
- 2012 Etholwyd yn Gymrawd Cymdeithas Cemegwyr Olew America
- Etholwyd 2013 yn Gymrawd Anrhydeddus yr Internat. Soc. ar gyfer Biotechnol a Biocatalysts
- Medal Chevreul 2014 (SFEL, Ffrainc)
- Gwobr Darlith Morton 2016 (Cymdeithas Biocemegol)
- 2016 Gwobr Stephen S Chang (AOCS, ar gyfer cymhwyso ymchwil sylfaenol i ddiwydiant)
- 2024 Ysgolhaig ranked iawn ar ScholarGPS.
Ar gyfer hobi, mae John yn dringo creigiau. Mae wedi gwneud dros 1200 o esgyniadau cyntaf wedi'u lledaenu dros bedwar cyfandir, ac mae wedi ysgrifennu sawl llyfr tywys.
Contact Details
Harwood@caerdydd.ac.uk
+44 29208 74108
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
+44 29208 74108
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
