Yr Athro Tom Margrain

2026

• Binns, A. M. et al., 2026. Oral glycoside supplement (triterpenoid saponins) for early and intermediate stage age-related macular degeneration (SAMADI trial): study protocol for a double masked randomised placebo-controlled feasibility trial. Pilot and Feasibility Studies (10.1186/s40814-026-01888-6)

2025

• Nollett, C. et al. 2025. Involving stakeholders in designing a mental health curriculum for staff in the vision impairment sector. British Journal of Visual Impairment 43 (3), pp.882-894. (10.1177/02646196241250210)

2024

• Pattni, K. et al. 2024. Visual pigment concentration and photoreceptor outer segment length in the human retina. Ophthalmic and Physiological Optics 44 (5), pp.917-924. (10.1111/opo.13307)
• Goddard, P. et al. 2024. Seeing art differently: design considerations to improve visual art engagement for people with low vision. Presented at: ACM Designing Interactive Systems Conference Copenhagen, Denmark 1-5 July 2024. Published in: Vallgarda, A. et al., Proceedings of the 2024 ACM Designing Interactive Systems Conference. New York, US: ACM. , pp.2820-2832. (10.1145/3643834.3660675)

2021

• Eslambolchilar, P. et al. 2021. Augmented reality glasses as a mobility aid for people with low vision: a feasibility study of experiences and requirements. Presented at: ACM CHI Conference on Human Factors in Computing Systems Yokohama, Japan 8-13 May 2021. CHI '21: Proceedings of the 2021 CHI Conference on Human Factors in Computing Systems. ACM. , pp.729. (10.1145/3411764.3445327)

2020

• Htike, H. M. et al. 2020. Ability of head-mounted display technology to improve mobility in people with low vision: a systematic review. Translational Vision Science & Technology 9 (10) 26. (10.1167/tvst.9.10.26)
• Margrain, T. H. et al. 2020. Functional imaging of the outer retinal complex using high fidelity imaging retinal densitometry. Scientific Reports 10 4494. (10.1038/s41598-020-60660-9)
• Callaghan, T. , Margrain, T. H. and Binns, A. M. 2020. The effect of systemic hyperoxia and hypoxia on scotopic thresholds in people with early and intermediate age-related macular degeneration. Current Eye Research 45 (10), pp.1273-1282. (10.1080/02713683.2020.1739315)

2019

• Cassels, N. K. et al. 2019. Microperimetry in age-related macular degeneration: an evidence-base for Pattern Deviation probability analysis in microperimetry. Translational Vision Science & Technology 8 (6) 48. (10.1167/tvst.8.6.48)
• Dunn, M. J. et al. 2019. An automated segmentation approach to calibrating infantile nystagmus waveforms. Behavior Research Methods 51 (5), pp.2074-2084. (10.3758/s13428-018-1178-5)
• Morny, E. K. A. et al. 2019. The relationship between the photopic negative response and retinal ganglion cell topography. Investigative Ophthalmology & Visual Science 60 (6), pp.1879-1887. (10.1167/iovs.18-25272)
• Nollett, C. et al. 2019. Depressive symptoms in people with a vision impairment: A cross-sectional study to identify who is most at risk. BMJ Open 9 (1) e026163. (10.1136/bmjopen-2018-026163)

2018

• Robinson, D. G. et al. 2018. Low-­level night-­time light-­therapy for age-­related macular degeneration: a randomized clinical trial. Investigative Ophthalmology & Visual Science 59 (11), pp.4531-4541. (10.1167/iovs.18-24284)
• Robinson, G. et al. 2018. An evaluation of a battery of functional and structural tests as predictors of likely risk of progression of age-related macular degeneration. Investigative Ophthalmology & Visual Science 60 , pp.580-589. (10.1167/iovs.18-25092)
• Cassels, N. et al. 2018. The use of microperimetry in assessing visual function in age-related macular degeneration. Survey of Ophthalmology 63 (1), pp.40-55. (10.1016/j.survophthal.2017.05.007)

2017

• Ravenscroft, D. et al., 2017. AMD classification in choroidal OCT using hierarchical texton mining. Presented at: ACIVS 2017 Antwerp, Belgium 18-21 Sep 2017. Published in: Blanc-Talon, J. et al., Advanced Concepts for Intelligent Vision Systems. Vol. 10617.Lecture Notes in Artificial Intelligence Cham, Switzerland: Springer. , pp.237-248. (10.1007/978-3-319-70353-4_21)
• Dunn, M. et al. 2017. The effect of gaze angle on visual acuity in infantile nystagmus. Investigative Ophthalmology and Visual Science 58 (1), pp.642-650. (10.1167/iovs.16-20370)

2016

• Acton, J. H. et al. 2016. Effect of a home visit-based low vision rehabilitation intervention on visual function outcomes: an exploratory randomized controlled trial. Investigative Ophthalmology & Visual Science 57 (15), pp.6662-6667. (10.1167/iovs.16-19901)
• Terry, L. et al. 2016. Automated Retinal Layer Segmentation Using Spectral Domain Optical Coherence Tomography: Evaluation of Inter-Session Repeatability and Agreement between Devices. Plos One 11 (9) e0162001. (10.1371/journal.pone.0162001)
• van der Aa, H. et al., 2016. Psychosocial interventions to improve mental health in adults with vision impairment: systematic review and meta-analysis. Ophthalmic And Physiological Optics 36 (5), pp.584-606. (10.1111/opo.12313)
• Nollett, C. L. et al. 2016. Depression in Visual Impairment Trial (DEPVIT): a randomized clinical trial of depression treatments in people with low vision. Investigative Ophthalmology & Visual Science 57 (10), pp.4247-4254. (10.1167/iovs.16-19345)
• Deng, J. et al., 2016. Age-related macular degeneration detection and stage classification using choroidal OCT images. Presented at: ICIAR 2016 Póvoa de Varzim, Portugal 13-15 Jul 2016. Published in: Campilho, A. and Karray, F. eds. Image Analysis and Recognition: ICIAR 2016. Vol. 9730.Lecture Notes in Computer Science Cham, Switzerland: Springer Verlag. , pp.707-715. (10.1007/978-3-319-41501-7_79)
• Acton, J. H. et al. 2016. Effect of rehabilitation worker input on visual function outcomes in individuals with low vision: study protocol for a randomised controlled trial. Trials 17 105. (10.1186/s13063-016-1235-2)
• Nollett, C. et al. 2016. High prevalence of untreated depression in patients accessing low-vision services. Ophthalmology 123 (2), pp.440-441. (10.1016/j.ophtha.2015.07.009)

2015

• Morny, E. K. A. et al. 2015. Electrophysiological ON and OFF responses in autosomal dominant optic atrophy. Investigative Ophthalmology & Visual Science 56 (13), pp.7629-7637. (10.1167/iovs.15-17951)
• van der Aa, H. P. A. et al., 2015. Stepped care for depression and anxiety in visually impaired older adults: multicentre randomised controlled trial. BMJ 351 h6127. (10.1136/bmj.h6127)
• Dunn, M. et al. 2015. Visual processing in infantile nystagmus is not slow. Investigative Ophthalmology & Visual Science 56 (9), pp.5094-5101. (10.1167/iovs.15-16977)

2014

• Dunn, M. et al. 2014. Author response: grating visual acuity in infantile nystagmus in the absence of image motion [Letter]. Investigative Ophthalmology and Visual Science 55 (8), pp.4955-4957. (10.1167/iovs.14-15070)
• Gaffney, A. J. et al. 2014. How effective is eccentric viewing training? A systematic literature review. Ophthalmic and Physiological Optics 34 (4), pp.427-437. (10.1111/opo.12132)
• McKeague, C. et al. 2014. Low-level night-time light therapy for age-related macular degeneration (ALight): study protocol for a randomized controlled trial. Trials 15 246. (10.1186/1745-6215-15-246)
• Wood, A. , Margrain, T. H. and Binns, A. 2014. Detection of Early Age-related macular degeneration using novel functional parameters of the focal cone electroretinogram. PLoS ONE 9 (5) e96742. (10.1371/journal.pone.0096742)
• Dunn, M. J. et al. 2014. Grating visual acuity in infantile nystagmus in the absence of image motion. Investigative Ophthalmology & Visual Science 55 (4), pp.2682-2686. (10.1167/iovs.13-13455)
• Gaffney, A. J. , Binns, A. and Margrain, T. H. 2014. Measurement of cone dark adaptation: a comparison of four psychophysical methods. Documenta Ophthalmologica 128 (1), pp.33-41. (10.1007/s10633-013-9418-6)

2013

• Jones, P. H. et al. 2013. Stress and visual function in infantile nystagmus syndrome. Investigative Ophthalmology and Visual Science 54 (13), pp.7943-7951. (10.1167/iovs.13-12560)
• Gaffney, A. J. , Binns, A. and Margrain, T. H. 2013. The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration. Documenta Ophthalmologica 127 (3), pp.191-199. (10.1007/s10633-013-9400-3)
• van der Aa, H. P. A. et al., 2013. Stepped-care to prevent depression and anxiety in visually impaired older adults - design of a randomised controlled trial. BMC Psychiatry 13 209. (10.1186/1471-244X-13-209)

2012

• Binns, A. et al. 2012. How effective is low vision service provision? A systematic review. Survey of Ophthalmology 57 (1), pp.34-65. (10.1016/j.survophthal.2011.06.006)
• Gaffney, A. J. , Binns, A. and Margrain, T. H. 2012. Aging and cone dark adaptation. Optometry and Vision Science 89 (8), pp.1219-1224. (10.1097/OPX.0b013e318263c6b1)
• Jones, P. H. et al. 2012. The impact of stress on visual performance in congenital nystagmus. In: Harris, C. M. , Gottlob, I. and Sanders, J. eds. The Challenge of Nystagmus. Nystagmus Network. , pp.239-260.
• Khadka, J. et al., 2012. Listening to voices of children with a visual impairment: A focus group study. British Journal of Visual Impairment 30 (3), pp.182-196. (10.1177/0264619612453105)
• Margrain, T. , Smith, D. and Nollett, C. 2012. Depression and Vision Loss in Ageing. Optometry in Practice 13 (2)
• Margrain, T. H. et al. 2012. The depression in Visual Impairment Trial (DEPVIT): trial design and protocol. BMC Psychiatry 12 (1) 57. (10.1186/1471-244X-12-57)

2011

• Wood, A. et al. 2011. Retinal and choroidal thickness in early age-related macular degeneration. American Journal of Ophthalmology 152 (6), pp.1030-1038. (10.1016/j.ajo.2011.05.021)
• Wood, A. , Margrain, T. H. and Binns, A. 2011. The effect of bleach duration and age on the ERG photostress test. Graefe's Archive for Clinical and Experimental Ophthalmology 249 (9), pp.1359-1365. (10.1007/s00417-011-1627-7)
• Court, H. J. et al. 2011. How effective is the new community-based Welsh low vision service?. British Journal of Ophthalmology 95 (2), pp.178-184. (10.1136/bjo.2010.179606)
• Dickinson, C. et al., 2011. A profile of low vision services in England: the Low Vision Service Model Evaluation (LOVSME) project [Editorial]. Eye 25 (7), pp.829-831. (10.1038/eye.2011.112)
• Gaffney, A. J. , Binns, A. and Margrain, T. H. 2011. The repeatability of the Goldmann-Weekers adaptometer for measuring cone adaptation. Documenta Ophthalmologica 122 (2), pp.71-75. (10.1007/s10633-011-9261-6)
• Gaffney, A. J. , Binns, A. and Margrain, T. H. 2011. Topography of Cone Dark Adaptation Deficits in Age-Related Maculopathy. Optometry and Vision Science 88 (9), pp.1080-1087. (10.1097/OPX.0b013e3182223697)

2010

• O'Connor, E. , Margrain, T. H. and Freeman, T. C. A. 2010. Age, eye movement and motion discrimination. Vision Research 50 (23), pp.2588-2599. (10.1016/j.visres.2010.08.015)
• Court, H. , Greenland, K. and Margrain, T. H. 2010. Measuring patient anxiety in primary care: Rasch analysis of the 6-item Spielberger State Anxiety Scale. Value In Health 13 (6), pp.813-819. (10.1111/j.1524-4733.2010.00758.x)
• Khadka, J. et al. 2010. Development of the 25-item Cardiff Visual Ability Questionnaire for Children (CVAQC). British Journal of Ophthalmology 94 (6), pp.730-735. (10.1136/bjo.2009.171181)
• Kolarik, A. J. , Margrain, T. H. and Freeman, T. C. A. 2010. Precision and accuracy of ocular following: influence of age and type of eye movement. Experimental Brain Research 201 (2), pp.271-282. (10.1007/s00221-009-2036-6)
• Ryan, B. and Margrain, T. H. 2010. Registration for people with sight impairment: Fit for purpose?. British Journal of Ophthalmology 94 (12), pp.1692-1693. (10.1136/bjo.2009.178558)
• Ryan, B. and Margrain, T. H. 2010. Research findings no 28: All Wales visual impairment database. Project Report.London, UK: Thomas Pocklington Trust.
• Ryan, B. et al. 2010. Occasional paper no 24: All Wales visual impairment database. Project Report.London, UK: Thomas Pocklington Trust.
• Ryan, B. et al. 2010. The newly established primary care based Welsh Low Vision Service is effective and has improved access to low vision services in Wales. Ophthalmic And Physiological Optics 30 (4), pp.358-364. (10.1111/j.1475-1313.2010.00729.x)

2009

• Tumlinson, A. R. et al. 2009. Techniques for extraction of depth-resolved in vivo human retinal intrinsic optical signals with optical coherence tomography. Japanese Journal of Ophthalmology 53 (4), pp.315-326. (10.1007/s10384-009-0684-5)
• Carson, D. , Margrain, T. H. and Patel, A. 2009. Reply: Lipofuscin phototoxicity: Reality or myth? [Letter]. Journal of Cataract & Refractive Surgery 35 (8), pp.1479-1480. (10.1016/j.jcrs.2009.03.032)
• Carson, D. , Margrain, T. H. and Patel, A. 2009. Reply: Refractive error and age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 35 (7), pp.1321-1322. (10.1016/j.jcrs.2009.02.021)
• Carson, D. , Margrain, T. H. and Patel, A. 2009. Reply: Retinal phototoxicity in the aging pseudophakic and phakic eye [Letter]. Journal of Cataract & Refractive Surgery 35 (2), pp.210-211. (10.1016/j.jcrs.2008.11.017)
• Court, H. , Greenland, K. and Margrain, T. H. 2009. Predicting state anxiety in optometric practice. Optometry and Vision Science 86 (11), pp.1295-1302. (10.1097/OPX.0b013e3181bb4212)
• Court, H. J. , Greenland, K. and Margrain, T. H. 2009. Evaluating the association between anxiety and satisfaction. Optometry and Vision Science 86 (3), pp.216-221. (10.1097/OPX.0b013e318196cf59)

2008

• Carson, D. , Margrain, T. h. and Patel, A. 2008. New approach to evaluate retinal protection by intraocular lenses against age-related lipofuscin accumulation-mediated retinal phototoxicity. Journal of Cataract & Refractive Surgery 34 (10), pp.1785-1792. (10.1016/j.jcrs.2008.06.034)
• Court, H. , Greenland, K. and Margrain, T. H. 2008. Evaluating patient anxiety levels during contact lens fitting. Optometry and Vision Science 85 (7), pp.574-580. (10.1097/OPX.0b013e31817dad7a)
• Khadka, J. et al. 2008. Focusing children in focus groups [Abstract]. Ophthalmic and Physiological Optics 28 (1), pp.99-99. (10.1111/j.1475-1313.2007.00530_11.x)
• Kolarik, A. J. , Freeman, T. C. A. and Margrain, T. H. 2008. Age and eye movement [Abstract]. Perception 37 (2), pp.314-314. (10.1068/ava07)
• Ryan, B. , Court, H. J. and Margrain, T. H. 2008. Measuring low vision service outcomes: Rasch Analysis of the seven-item National Eye Institute visual function questionnaire. Optometry and Vision Science 85 (2), pp.112-121. (10.1097/OPX.0b013e31816225dc)

2007

• Wiggins, D. et al. 2007. Infantile nystagmus adapts to visual demand. Investigative Ophthalmology and Visual Science 48 (5), pp.2089-2094. (10.1167/iovs.06-1108)
• Binns, A. and Margrain, T. H. 2007. Evaluating Retinal Function in Age-Related Maculopathy with the ERG Photostress Test. Investigative Ophthalmology and Visual Science 48 (6), pp.2806-2813. (10.1167/iovs.06-0392)
• Court, H. , Greenland, K. and Margrain, T. H. 2007. Content development of the optometric patient anxiety scale. Optometry and Vision Science 84 (8), pp.729-744. (10.1097/OPX.0b013e31812f7361)

2006

• Binns, A. and Margrain, T. H. 2006. Development of a technique for recording the focal rod ERG. Ophtalmic and physiological optics 26 (1), pp.71-79. (10.1111/j.1475-1313.2005.00355.x)

2005

• Binns, A. and Margrain, T. H. 2005. Evaluation of retinal function using the Dynamic Focal Cone ERG. Ophthalmic and Physiological Optics 25 (6), pp.492-500. (10.1111/j.1475-1313.2005.00338.x)
• Margrain, T. H. , Ryan, B. and Wild, J. M. 2005. A revolution in Welsh low vision service provision. British Journal of Ophthalmology 89 (8), pp.933-934. (10.1136/bjo.2005.066142)
• Qin, X. et al., 2005. Anisometropia is independently associated with both spherical and cylindrical ametropia. Investigative Ophthalmology & Visual Science 46 (11), pp.4024-4031. (10.1167/iovs.05-0120)

2004

• Margrain, T. H. et al. 2004. Do blue light filters confer protection against age-related macular degeneration?. Progress in Retinal and Eye Research 23 (5), pp.523-531. (10.1016/j.preteyeres.2004.05.001)
• Margrain, T. H. , Court, H. and Greenland, K. 2004. Content development of the optometric patient anxiety scale. Progress in Retinal and Eye Research 23 (5), pp.523-531.

2003

• Margrain, T. H. , Greenland, K. and Anderson, J. 2003. Evaluating anxiety in patients attending optometric practice. Ophthalmic and Physiological Optics 23 (4), pp.287-293. (10.1046/j.1475-1313.2003.00118.x)

2002

• Margrain, T. H. and Thomson, D. 2002. Sources of variability in the clinical photostress test. Ophthalmic and Physiological Optics 22 (1), pp.61-67. (10.1046/j.1475-1313.2002.00005.x)
• Freeman, T. C. A. , Naji, J. J. and Margrain, T. H. 2002. Head-centred motion perception in the ageing visual system. Spatial Vision 15 (2), pp.117-127. (10.1163/15685680252875110)

2000

• Margrain, T. H. 2000. Helping blind and partially sighted people to read: the effectiveness of low vision aids [Letter]. British Journal of Ophthalmology 84 (8), pp.919-921. (10.1136/bjo.84.8.919)

1999

• Margrain, T. H. 1999. Minimising the impact of visual impairment: Low vision aids are a simple way of alleviating impairment [Editorial]. BMJ 318 (7197), pp.1504.

1997

• Margrain, T. H. and Thomson, W. D. 1997. Recovery of spatial vision during dark adaptation in normal subjects. Ophthalmic and Physiological Optics 17 (6), pp.509-515. (10.1046/j.1475-1313.1997.97000331.x)
• Owen, C. G. , Margrain, T. H. and Woodward, E. G. 1997. Use of contact lenses by firefighters. Part 1: Questionnaire data. Ophthalmic and Physiological Optics 17 (2), pp.102-111. (10.1046/j.1475-1313.1997.96000592.x)
• Owen, C. G. , Margrain, T. H. and Woodward, E. G. 1997. Use of contact lenses by firefighters: Part 2. Clinical evaluation. Ophthalmic and Physiological Optics 17 (3), pp.205-215. (10.1111/j.1475-1313.1997.opo_021.x)

1996

• Margrain, T. H. , Birch, J. and Owen, C. G. 1996. Colour vision requirements of firefighters. Occupational Medicine 46 (2), pp.114-124. (10.1093/occmed/46.2.114)
• Margrain, T. H. and Owen, C. 1996. The misting characteristics of spectacle lenses. Ophthalmic and Physiological Optics 16 (2), pp.108-114. (10.1046/j.1475-1313.1996.95000232.x)
• Margrain, T. H. , Owen, C. G. and Woodward, E. G. 1996. Prevalence of spectacle and contact lens wear in the UK fire service. Ophthalmic and Physiological Optics 16 (1), pp.11-18. (10.1046/j.1475-1313.1996.95000089.x)

1995

• Owen, C. G. , Margrain, T. H. and Woodward, E. G. 1995. Aetiology and prevalence of eye injuries within the United Kingdom fire service. Eye 9 (6S), pp.54-58.

1994

• Margrain, T. H. and Birch, J. 1994. A suitable study to evaluate colour vision requirements for firefighters?. Occupational Medicine 44 (5), pp.257-258. (10.1093/occmed/44.5.257)