Athro Emeritws Aled Phillips

2021

• Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297 (3) 100987. (10.1016/j.jbc.2021.100987)
• Holmes, J. et al., 2021. Acute kidney injury demographics and outcomes: changes following introduction of electronic acute kidney injury alerts—an analysis of a national dataset. Nephrology Dialysis Transplantation 36 (8), pp.1433-1439. (10.1093/ndt/gfaa071)
• Khalid, S. A. et al., 2021. Gum Arabic in renal disease (GARDS Study): Clinical evidence of dietary supplementation impact on progression of renal dysfunction. Journal of Functional Foods 82 104515. (10.1016/j.jff.2021.104515)
• Jones, A. et al., 2021. Using electronic AKI alerts to define the epidemiology of acute kidney injury in renal transplants. Journal of Nephrology 34 , pp.829-838. (10.1007/s40620-020-00869-z)

2020

• Holmes, J. et al., 2020. Recurrent acute kidney injury: predictors and impact in a large population-based cohort. Nephrology Dialysis Transplantation 35 (8), pp.1361-1369. (10.1093/ndt/gfz155)
• Midgley, A. C. et al. 2020. Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions. American Journal of Pathology 190 (6), pp.1236-1255. (10.1016/j.ajpath.2020.02.012)
• Foxwell, D. A. et al. 2020. Epidemiology of emergency department acute kidney injury. Nephrology 25 (6), pp.457-466. (10.1111/nep.13672)
• Gubb, S. et al. 2020. Acute kidney injury in children based on electronic alerts. Journal of Pediatrics 220 , pp.4-6.e1. (10.1016/j.jpeds.2019.11.019)

2019

• Allen, L. A. et al. 2019. Cardiovascular and renal outcomes following percutaneous coronary intervention in a population with renal disease: a case-control study. QJM: An International Journal of Medicine 112 (9), pp.669-674. (10.1093/qjmed/hcz130)

2018

• Phillips, D. et al. 2018. The influence of socioeconomic status on presentation and outcome of acute kidney injury. QJM: An International Journal of Medicine 111 (12), pp.849-857. (10.1093/qjmed/hcy180)
• Wang, J. et al., 2018. Structural characterization of an α-1, 6-linked galactomannan from natural Cordyceps 2 sinensis. Food Hydrocolloids 78 , pp.77-91. (10.1016/j.foodhyd.2017.07.024)
• Huang, D. et al., 2018. Cordyceps Sinensis: anti-fibrotic and inflammatory effects of a cultured polysaccharide extract. Bioactive Carbohydrates and Dietary Fibre 14 , pp.2-8. (10.1016/j.bcdf.2017.07.012)

2017

• Midgley, A. C. et al. 2017. Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype. Science Signaling 10 (506) eaao1822. (10.1126/scisignal.aao1822)
• Holmes, J. et al. 2017. Community acquired acute kidney injury: findings from a large population cohort. QJM: An International Journal of Medicine 110 (11), pp.741-746. (10.1093/qjmed/hcx151)
• Phillips, D. et al. 2017. Seasonal pattern of incidence and outcome of acute kidney injury: A national study of Welsh AKI electronic alerts. International Journal of Clinical Practice 71 (9) e13000. (10.1111/ijcp.13000)
• Holmes, J. et al., 2017. Acute kidney injury: electronic alerts in primary care - findings from a large population cohort. QJM: An International Journal of Medicine 110 (9), pp.577-582. (10.1093/qjmed/hcx080)
• Holmes, J. et al., 2017. The incidence of pediatric acute kidney injury is increased when identified by a change in a creatinine-based electronic alert. Kidney International 92 (2), pp.432-439. (10.1016/j.kint.2017.03.009)
• Wang, J. et al., 2017. Structural characterization and immunostimulatory activity of a glucan from natural Cordyceps sinensis. Food Hydrocolloids 67 , pp.139-147. (10.1016/j.foodhyd.2017.01.010)
• Wang, J. et al., 2017. Comparison of structural features and antioxidant activity of polysaccharides from natural and cultured Cordyceps sinensis. Food Science and Biotechnology 26 (1) 55. (10.1007/s10068-017-0008-3)

2016

• Holmes, J. et al., 2016. Acute kidney injury in the era of the AKI E-Alert. Clinical Journal of the American Society of Nephrology 11 (10.2215/CJN.05170516)
• Johnson, F. et al. 2016. The impact of acute kidney injury in diabetes mellitus. Journal of Thrombosis and Haemostatis 21 (6), pp.506-511. (10.1111/nep.12649)
• Midgley, A. C. et al. 2016. 17β‐estradiol ameliorates age‐associated loss of fibroblast function by attenuating IFN‐γ/STAT1‐dependent miR‐7 upregulation. Aging Cell 15 (3), pp.531-541. (10.1111/acel.12462)
• Martin, J. et al. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291 , pp.13789-13801. (10.1074/jbc.M115.670521)
• El-hassan, E. E. A. et al., 2016. Glomerular disease and acute kidney injury in Sudan: Demographics, histological diagnosis and outcome. South African Medical Journal 106 (7), pp.704-708. (10.7196/SAMJ.2016.v106i7.10392)

2015

• Beltrami, C. et al., 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1 (2), pp.151-166. (10.3390/ncrna1020151)
• Roberts, G. et al., 2015. Acute kidney injury risk assessment at the hospital front door: what is the best measure of risk?. Clinical Kidney Journal 8 (6), pp.673-680. (10.1093/ckj/sfv080)
• Midgley, A. C. et al. 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. Journal of Biological Chemistry 290 (18), pp.11218-11234. (10.1074/jbc.M114.625939)

2014

• Wonnacott, A. et al. 2014. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clinical Journal of the American Society of Nephrology 9 (6), pp.1007-1014. (10.2215/CJN.07920713)
• Talabani, B. et al. 2014. Epidemiology and outcome of community-acquired acute kidney injury. Nephrology 19 (5), pp.282-287. (10.1111/nep.12221)
• Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184 (4), pp.996-1009. (10.1016/j.ajpath.2013.12.028)
• Midgley, A. C. et al. 2014. MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. Aging Cell 13 (2), pp.235-244. (10.1111/acel.12167)
• Meran, S. et al. 2014. How good are we at managing acute kidney injury in hospital?. Clinical Kidney Journal 7 (2), pp.144-150. (10.1093/ckj/sfu010)
• Phillips, B. M. et al., 2014. Severe hyperkalaemia: demographics and outcome. Clinical Kidney Journal 7 (2), pp.127-133. (10.1093/ckj/sft158)
• Phillips, L. et al., 2014. The long-term impact of eGFR reporting on referral patterns. European Journal of Internal Medicine 25 (1), pp.97-101. (10.1016/j.ejim.2013.08.001)
• Yao, X. et al., 2014. Cordyceps sinensis: in vitro anti-fibrotic bioactivity of natural and cultured preparations. Food Hydrocolloids 35 , pp.444-452. (10.1016/j.foodhyd.2013.06.023)

2013

• Jones, N. J. et al. 2013. Prevalence of risk factors for foot ulceration in a general haemodialysis population. International Wound Journal 10 (6), pp.683-688. (10.1111/j.1742-481X.2012.01044.x)
• Jones, R. K. et al. 2013. Diabetes and renal disease: who does what?. Clinical Medicine 13 (5), pp.460-464. (10.7861/clinmedicine.13-5-460)
• Meran, S. et al. 2013. Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding. American Journal of Pathology 182 (6), pp.2223-2240. (10.1016/j.ajpath.2013.02.038)
• Midgley, A. C. et al. 2013. Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation Is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Journal of Biological Chemistry 288 (21), pp.14824-14838. (10.1074/jbc.M113.451336)
• Nie, S. et al., 2013. Bioactive polysaccharides from Cordyceps sinensis: Isolation, structure features and bioactivities [Review]. Bioactive Carbohydrates and Dietary Fibre 1 (1), pp.38-52. (10.1016/j.bcdf.2012.12.002)
• Pan, M. et al., 2013. Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food and Chemical Toxicology 58 , pp.487-494. (10.1016/j.fct.2013.04.037)
• Phillips, L. A. et al., 2013. Acute kidney injury risk factor recognition in three teaching hospitals in Ethiopia. South African Medical Journal 103 (6), pp.413-418. (10.7196/samj.6424)
• Riley, S. G. et al. 2013. Renal impairment amongst acute hospital admissions in a rural Ethiopian hospital. Nephrology 18 (2), pp.92-96. (10.1111/nep.12002)

2012

• Beltrami, C. et al. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4), pp.875-879. (10.1042/BST20120090)
• Jenkins, R. H. et al. 2012. Pleiotropy of microRNA-192 in the kidney. Biochemical Society Transactions 40 (4), pp.762-767. (10.1042/BST20120085)
• Jenkins, R. H. et al. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443 (2), pp.407-416. (10.1042/BJ20111861)
• Wonnacott, A. et al. 2012. Applying estimated glomerular filtration rate to an ageing population: are we in danger of becoming ageist?. European Journal of Internal Medicine 23 (8), pp.705-710. (10.1016/j.ejim.2012.08.012)
• Zhang, X. L. et al., 2012. Cordyceps sinensis decreases TGF-β1 dependent epithelial to mesenchymal transdifferentiation and attenuates renal fibrosis. Food Hydrocolloids 28 (1), pp.200-212. (10.1016/j.foodhyd.2011.12.016)
• Zheng, M. et al., 2012. Urinary mRNA markers of epithelial-mesenchymal transition correlate with progression of diabetic nephropathy. Clinical Endocrinology 76 (5), pp.657-664. (10.1111/j.1365-2265.2011.04192.x)

2011

• Michael, D. R. et al. 2011. The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell. Journal of Biological Chemistry 286 (22), pp.19523-19532. (10.1074/jbc.M111.233916)
• Meran, S. et al. 2011. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Journal of Biological Chemistry 286 (20), pp.17618-17630. (10.1074/jbc.M111.226563)
• Martin, J. et al. 2011. Post-transcriptional regulation of transforming growth factor beta-1 by microrna-744. PLoS ONE 6 (10) e25044. (10.1371/journal.pone.0025044)
• Asderakis, A. et al., 2011. RO-101 Nitric oxide post-perfusion levels differ in DCD and DBD donor transplants [Abstract]. Transplant International 24 (s2), pp.157. (10.1111/j.1432-2277.2011.01350.x)
• Bommayya, G. et al. 2011. Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial–mesenchymal transition of proximal tubular epithelial cells. International Journal of Biochemistry & Cell Biology 43 (12), pp.1739-1746. (10.1016/j.biocel.2011.08.009)
• Khammas, H. et al. 2011. Characterisation of the human ADAM15 promoter. Nephron Experimental Nephrology 118 (2), pp.e27-e38. (10.1159/000320698)
• Li, Q. et al., 2011. Monocytes induce proximal tubular epithelial-mesenchymal transition through NF-kappa B dependent upregulation of ICAM-1. Journal of Cellular Biochemistry 112 (6), pp.1585-1592. (10.1002/jcb.23074)
• Nie, S. et al., 2011. Elucidation of the structure of a bioactive hydrophilic polysaccharide from Cordyceps sinensis by methylation analysis and NMR spectroscopy. Carbohydrate Polymers 84 (3), pp.894-899. (10.1016/j.carbpol.2010.12.033)
• Phillips, A. O. and Phillips, G. O. 2011. Biofunctional behaviour and health benefits of a specific gum arabic. Food Hydrocolloids 25 (2), pp.165-169. (10.1016/j.foodhyd.2010.03.012)
• Tian, Y. et al., 2011. Leptospira santorosai serovar shermani detergent extract induces an increase in fibronectin production through a toll-like receptor 2-mediated pathway. Infection and Immunity 79 (3), pp.1134-1142. (10.1128/IAI.01287-09)

2010

• Simpson, R. M. L. et al. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176 (3), pp.1215-1228. (10.2353/ajpath.2010.090802)
• Jenkins, R. H. et al. 2010. A conserved stem loop motif in the 5'Untranslated Region regulates transforming growth factor-β1 translation. PLoS One 5 (8) e12283. (10.1371/journal.pone.0012283)
• Krupa, A. et al. 2010. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology 21 (3), pp.438-447. (10.1681/ASN.2009050530)
• Luo, D. D. , Phillips, A. O. and Fraser, D. J. 2010. Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell smad3 signaling via increased SnoN expression. American Journal of Pathology 176 (3), pp.1139-1147. (10.2353/ajpath.2010.090459)
• Meran, S. et al. 2010. Impact of chronic kidney disease management in primary care. QJM 104 (1), pp.27-34. (10.1093/qjmed/hcq151)
• Phillips, A. O. and Fraser, D. J. 2010. BMP-7 stops TGF-β in peritoneal fibrosis. Nephrology Dialysis Transplantation 25 (4), pp.1036-1038. (10.1093/ndt/gfq032)

2009

• Simpson, R. M. L. et al. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175 (5), pp.1915-1928. (10.2353/ajpath.2009.090045)
• Luo, D. D. et al. 2009. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrology Dialysis Transplantation 24 (9), pp.2655-2665. (10.1093/ndt/gfp208)
• Simpson, R. M. et al. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90 (2), pp.A128-A129.
• Glover, D. A. et al. 2009. Acacia(sen) SUPERGUM™ (gum arabic): an evaluation of potential health benefits in human subjects. Food Hydrocolloids 23 (8), pp.2410-2415. (10.1016/j.foodhyd.2009.06.020)
• Phillips, L. A. , Donovan, K. and Phillips, A. O. 2009. Renal quality outcomes framework and eGFR: impact on secondary care. QJM 102 (6), pp.415-423. (10.1093/qjmed/hcp030)
• Webber, J. P. et al. 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175 (1), pp.148-160. (10.2353/ajpath.2009.080837)
• Webber, J. P. et al. 2009. Hyaluronan orchestrates transforming growth factor-β1-dependent maintenance of myofibroblast phenotype. Journal of Biological Chemistry 284 (14), pp.9083-9092. (10.1074/jbc.M806989200)

2008

• Meran, S. et al. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283 (10), pp.6530-6545. (10.1074/jbc.M704819200)
• Lewis, A. G. et al. 2008. Diabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis. Histology and Histopathology 23 (6), pp.731-739.
• Chang, C. et al., 2008. Transforming growth factor-β1 decreases epithelial sodium channel functionality in renal collecting duct cells via a Smad4-dependent pathway. Nephrology Dialysis Transplantation 23 (4), pp.1126-1134. (10.1093/ndt/gfm786)
• Fraser, D. J. et al. 2008. Y-box protein-1 controls transforming growth factor-β1 translation in proximal tubular cells. Kidney International 73 (6), pp.724-732. (10.1038/sj.ki.5002719)
• Liu, B. C. et al., 2008. Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. American Journal of Nephrology 28 (1), pp.143-151. (10.1159/000110019)
• Meran, S. et al. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16 (2), pp.A12. (10.1111/j.1524-475X.2008.00371.x)
• Nair, S. et al., 2008. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. Journal of Nephology 21 (3), pp.400-405.

2007

• Zhang, M. et al., 2007. Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. Journal of Biological Chemistry 282 (39), pp.28639-28647. (10.1074/jbc.m700594200)
• Meran, S. et al. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282 (35), pp.25687-25697. (10.1074/jbc.M700773200)

2006

• Khera, T. et al., 2006. Glucose enhances mesangial cell apoptosis. Laboratory Investigation 86 (6), pp.566-577. (10.1038/labinvest.3700418)
• Matsumoto, N. et al., 2006. Butyrate modulates TGF-beta1 generation and function: potential renal benefit for Acacia(sen) SUPERGUM (gum arabic)?. Kidney International 69 (2), pp.257-65. (10.1038/sj.ki.5000028)
• Matsumoto, N. et al., 2006. The effects of butyrate on TGF-β1 generation and function. Potential renal benefit for Acacia(sen) SUPER GUM™(gum arabic)?. Foods & Food Ingredients Journal of Japan 211 (1), pp.62-71. (10.34457/ffij.211.1_062)
• Rashid Selbi, W. et al. 2006. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. Kidney International 70 (7), pp.1287-1295. (10.1038/sj.ki.5001760)
• Zhang, M. , Fraser, D. J. and Phillips, A. O. 2006. ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. American Journal of Pathology 169 (4), pp.1282-1293. (10.2353/ajpath.2006.050921)

2005

• Zhang, X. L. et al. 2005. Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling. The Journal of Biological Chemistry 280 (13), pp.12239-12245. (10.1074/jbc.M413284200)
• Zhang, X. L. et al., 2005. Bone morphogenic protein-7 inhibits monocyte-stimulated TGF-beta1 generation in renal proximal tubular epithelial cells. Journal of the American Society of Nephrology 16 (1), pp.79-89. (10.1681/ASN.2004050395)
• Craig, K. L. et al., 2005. The impact of an out-reach clinic on referral of patients with renal impairment. Nephron Clinical Practice 101 (4), pp.c168-c173. (10.1159/000087392)
• Craig, K. J. et al. 2005. Anemia and diabetes in the absence of nephropathy. Diabetes Care 28 (5), pp.1118-1123. (10.2337/diacare.28.5.1118)

2004

• Zhang, X. L. et al., 2004. Renal proximal tubular epithelial cell transforming growth factor-beta1 generation and monocyte binding. American Journal of Pathology 165 (3), pp.763-773.
• Ito, T. et al., 2004. Hyaluronan regulates transforming growth factor-beta1 receptor compartmentalization. The Journal of Biological Chemistry 279 (24), pp.25326-25332. (10.1074/jbc.M403135200)
• Ito, T. et al., 2004. Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. American Journal of Pathology 164 (6), pp.1979-1988. (10.1016/s0002-9440(10)63758-3)

2003

• Wong, T. Y. H. et al., 2003. Glucose-mediated induction of TGF-beta 1 and MCP-1 in mesothelial cells in vitro is osmolality and polyol pathway dependent. Kidney International 63 (4), pp.1404-1416. (10.1046/j.1523-1755.2003.00883.x)
• Craig, K. J. et al. 2003. Identification and management of diabetic nephropathy in the diabetes clinic. Diabetes Care 26 (6), pp.1806-1811. (10.2337/diacare.26.6.1806)
• Fraser, D. J. et al. 2003. Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop. American Journal of Pathology 163 (6), pp.2565-2574.
• Tian, Y. et al., 2003. TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype. American Journal of Physiology - Renal Physiology 285 (1), pp.F130-142. (10.1152/ajprenal.00408.2002)

2002

• Fraser, D. J. , Phillips, A. O. and Wakefield, L. 2002. Independent regulation of transforming growth factor-beta1 transcription and translation by glucose and platelet-derived growth factor. American Journal of Pathology 161 (3), pp.1039-1049.