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Yr Athro John Wild
Timau a rolau for John Wild
Pennaeth yr Ysgol, Ysgol Optometreg a Gwyddorau Gweledigaeth
Trosolwg
Trosolwg o Ymchwil
Mae fy niddordebau ymchwil yn ymwneud â (i) datblygu methodolegau ar gyfer mireinio, ac ar gyfer dehongli, yr archwiliad maes gweledol a (ii) y berthynas rhwng y canlyniadau swyddogaethol, h.y. y rhai o perimetreg a'r canlyniadau strwythurol, h.y. y rhai o ddelweddu.
Mae'r ymchwil yn canolbwyntio ar glawcoma ongl agored ac ar wenwyndra llygaid sy'n deillio o'r cyffur gwrth-epileptig, vigabatrin.
Trosolwg o Addysgu
Rwy'n darparu cyfres o 15 darlith ar y modiwl Ail Flwyddyn, OP2203, mewn Technegau Ymchwilio. Rwyf hefyd yn oruchwyliwr yn y Clinig Lens Cyswllt Trydedd Flwyddyn ar gyfer y modiwl OP3202 mewn Lensys Cyffwrdd a Gweledigaeth Isel.
Cyhoeddiad
2025
- Wild, J. M. , Smith, P. E. and Knupp, C. 2025. Machine-learning algorithms for the identification of visual field loss associated with the antiseizure medication vigabatrin-a proof of concept. British Journal of Ophthalmology 109 (8), pp.932-940. (10.1136/bjo-2024-325804)
2019
- Wild, J. , Smith, P. E. M. and Knupp, C. 2019. Objective derivation of the morphology and staging of visual field loss associated with long-term vigabatrin therapy. CNS Drugs 33 (8), pp.817-829. (10.1007/s40263-019-00634-2)
- Wild, J. M. et al. 2019. The topographical relationship between visual field loss and peripapillary retinal nerve fibre layer thinning arising from long-term exposure to vigabatrin. CNS Drugs 33 , pp.161-173. (10.1007/s40263-018-0583-8)
2018
- Acton, J. et al. 2018. Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy. Scientific Reports 8 15769. (10.1038/s41598-018-33781-5)
- Cassels, N. et al. 2018. The use of microperimetry in assessing visual function in age-related macular degeneration. Survey of Ophthalmology 63 (1), pp.40-55. (10.1016/j.survophthal.2017.05.007)
2013
- Wild, J. M. et al. 2013. Modelling the risk of visual field loss arising from long-term exposure to the antiepileptic drug vigabatrin: a cross-sectional approach. CNS Drugs 27 (10), pp.841-849. (10.1007/s40263-013-0100-z)
2012
- Morgan, J. E. et al. 2012. The accuracy of the inferior>superior>nasal>temporal neuroretinal rim area rule for diagnosing glaucomatous optic disc damage. Ophthalmology 119 (4), pp.723-730. (10.1016/j.ophtha.2011.10.004)
2010
- Maguire, M. J. et al., 2010. Prevalence of visual field loss following exposure to vigabatrin therapy: A systematic review. Epilepsia 51 (12), pp.2423-2431. (10.1111/j.1528-1167.2010.02772.x)
- North, R. V. et al. 2010. Electrophysiological evidence of early functional damage in glaucoma and ocular hypertension. Investigative Ophthalmology & Visual Science 51 (2), pp.1216-1222. (10.1167/iovs.09-3409)
- Ryan, B. et al. 2010. The newly established primary care based Welsh Low Vision Service is effective and has improved access to low vision services in Wales. Ophthalmic And Physiological Optics 30 (4), pp.358-364. (10.1111/j.1475-1313.2010.00729.x)
2009
- Lawthom, C. , Smith, P. E. M. and Wild, J. M. 2009. In utero exposure to vigabatrin: No indication of visual field loss. Epilepsia 50 (2), pp.318-321. (10.1111/j.1528-1167.2008.01700.x)
- Lawthom, C. , Smith, P. E. M. and Wild, J. M. 2009. Nasal retinal nerve fiber layer attenuation: A biomarker for vigabatrin toxicity. Ophthalmology 116 (3), pp.565-571. (10.1016/j.ophtha.2008.09.047)
- Wild, J. M. et al. 2009. Visual field loss in patients with refractory partial epilepsy treated with vigabatrin. CNS Drugs 23 (11), pp.965-982. (10.2165/11317650-000000000-00000)
2008
- Sheen, N. J. L. et al. 2008. Novel optometrist-led all Wales primary eye-care services: evaluation of a prospective case series. British Journal of Ophthalmology 93 (4), pp.435-438. (10.1136/bjo.2008.144329)
2007
- Wild, J. M. et al. 2007. Vigabatrin and epilepsy: lessons learned. Epilepsia 48 (7), pp.1318-1327. (10.1111/j.1528-1167.2007.01133.x)
- Wild, J. M. et al. 2007. The normal age-corrected and reaction time-corrected isopter derived by semi-automated kinetic perimetry. Ophthalmology 114 (6), pp.1065-1072. (10.1016/j.ophtha.2006.09.030)
2006
- Wild, J. M. et al. 2006. Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer. Investigative Ophthalmology and Visual Science 47 (3), pp.917-924. (10.1167/iovs.05-0854)
- Wild, J. M. et al. 2006. Evidence for a learning effect in short-wavelength automated perimetry. Ophthalmology 113 (2), pp.206-215. (10.1016/j.ophtha.2005.11.002)
2005
- Margrain, T. H. , Ryan, B. and Wild, J. M. 2005. A revolution in Welsh low vision service provision. British Journal of Ophthalmology 89 (8), pp.933-934. (10.1136/bjo.2005.066142)
2002
- Drasdo, N. et al. 2002. Ocular optics, electroretinography and primary open angle glaucoma. Ophthalmic and Physiological Optics 22 (5), pp.455-462. (10.1046/j.1475-1313.2002.00078.x)
2001
- Wild, J. 2001. Short wavelength automated perimetry. Acta Ophthalmologica Scandinavica 79 (6), pp.546-559. (10.1034/j.1600-0420.2001.790602.x)
- Hutchings, N. et al., 2001. Long-term fluctuation in short-wavelength automated perimetry in glaucoma suspects and glaucoma patients. Investigative Ophthalmology and Visual Science 42 (10), pp.2332-2337.
Articles
- Wild, J. M. , Smith, P. E. and Knupp, C. 2025. Machine-learning algorithms for the identification of visual field loss associated with the antiseizure medication vigabatrin-a proof of concept. British Journal of Ophthalmology 109 (8), pp.932-940. (10.1136/bjo-2024-325804)
- Wild, J. , Smith, P. E. M. and Knupp, C. 2019. Objective derivation of the morphology and staging of visual field loss associated with long-term vigabatrin therapy. CNS Drugs 33 (8), pp.817-829. (10.1007/s40263-019-00634-2)
- Wild, J. M. et al. 2019. The topographical relationship between visual field loss and peripapillary retinal nerve fibre layer thinning arising from long-term exposure to vigabatrin. CNS Drugs 33 , pp.161-173. (10.1007/s40263-018-0583-8)
- Acton, J. et al. 2018. Microperimetry and multimodal imaging in polypoidal choroidal vasculopathy. Scientific Reports 8 15769. (10.1038/s41598-018-33781-5)
- Cassels, N. et al. 2018. The use of microperimetry in assessing visual function in age-related macular degeneration. Survey of Ophthalmology 63 (1), pp.40-55. (10.1016/j.survophthal.2017.05.007)
- Wild, J. M. et al. 2013. Modelling the risk of visual field loss arising from long-term exposure to the antiepileptic drug vigabatrin: a cross-sectional approach. CNS Drugs 27 (10), pp.841-849. (10.1007/s40263-013-0100-z)
- Morgan, J. E. et al. 2012. The accuracy of the inferior>superior>nasal>temporal neuroretinal rim area rule for diagnosing glaucomatous optic disc damage. Ophthalmology 119 (4), pp.723-730. (10.1016/j.ophtha.2011.10.004)
- Maguire, M. J. et al., 2010. Prevalence of visual field loss following exposure to vigabatrin therapy: A systematic review. Epilepsia 51 (12), pp.2423-2431. (10.1111/j.1528-1167.2010.02772.x)
- North, R. V. et al. 2010. Electrophysiological evidence of early functional damage in glaucoma and ocular hypertension. Investigative Ophthalmology & Visual Science 51 (2), pp.1216-1222. (10.1167/iovs.09-3409)
- Ryan, B. et al. 2010. The newly established primary care based Welsh Low Vision Service is effective and has improved access to low vision services in Wales. Ophthalmic And Physiological Optics 30 (4), pp.358-364. (10.1111/j.1475-1313.2010.00729.x)
- Lawthom, C. , Smith, P. E. M. and Wild, J. M. 2009. In utero exposure to vigabatrin: No indication of visual field loss. Epilepsia 50 (2), pp.318-321. (10.1111/j.1528-1167.2008.01700.x)
- Lawthom, C. , Smith, P. E. M. and Wild, J. M. 2009. Nasal retinal nerve fiber layer attenuation: A biomarker for vigabatrin toxicity. Ophthalmology 116 (3), pp.565-571. (10.1016/j.ophtha.2008.09.047)
- Wild, J. M. et al. 2009. Visual field loss in patients with refractory partial epilepsy treated with vigabatrin. CNS Drugs 23 (11), pp.965-982. (10.2165/11317650-000000000-00000)
- Sheen, N. J. L. et al. 2008. Novel optometrist-led all Wales primary eye-care services: evaluation of a prospective case series. British Journal of Ophthalmology 93 (4), pp.435-438. (10.1136/bjo.2008.144329)
- Wild, J. M. et al. 2007. Vigabatrin and epilepsy: lessons learned. Epilepsia 48 (7), pp.1318-1327. (10.1111/j.1528-1167.2007.01133.x)
- Wild, J. M. et al. 2007. The normal age-corrected and reaction time-corrected isopter derived by semi-automated kinetic perimetry. Ophthalmology 114 (6), pp.1065-1072. (10.1016/j.ophtha.2006.09.030)
- Wild, J. M. et al. 2006. Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer. Investigative Ophthalmology and Visual Science 47 (3), pp.917-924. (10.1167/iovs.05-0854)
- Wild, J. M. et al. 2006. Evidence for a learning effect in short-wavelength automated perimetry. Ophthalmology 113 (2), pp.206-215. (10.1016/j.ophtha.2005.11.002)
- Margrain, T. H. , Ryan, B. and Wild, J. M. 2005. A revolution in Welsh low vision service provision. British Journal of Ophthalmology 89 (8), pp.933-934. (10.1136/bjo.2005.066142)
- Drasdo, N. et al. 2002. Ocular optics, electroretinography and primary open angle glaucoma. Ophthalmic and Physiological Optics 22 (5), pp.455-462. (10.1046/j.1475-1313.2002.00078.x)
- Wild, J. 2001. Short wavelength automated perimetry. Acta Ophthalmologica Scandinavica 79 (6), pp.546-559. (10.1034/j.1600-0420.2001.790602.x)
- Hutchings, N. et al., 2001. Long-term fluctuation in short-wavelength automated perimetry in glaucoma suspects and glaucoma patients. Investigative Ophthalmology and Visual Science 42 (10), pp.2332-2337.
Ymchwil
Mae fy ymchwil yn cynnwys tri maes: datblygu methodolegau ar gyfer mireinio'r archwiliad maes gweledol; y berthynas rhwng strwythur a swyddogaeth mewn glawcoma; ac ymchwilio i golli maes gweledol sy'n gysylltiedig â chyffuriau, yn enwedig y rhai sy'n gysylltiedig â therapi gwrth-gonvulsant.
Isolation of factors influencing the short-term and long-term fluctuation of the threshold response and the separation of the optical component of perimetric sensitivity from that of the neural component. The result of the visual field examination can be influence by a variety of artifacts which can mimic the appearance of both diffuse and focal loss, thus impairing the clinical precision of the examination. We have documented the presence of a learning effect in automated perimetry whereby perimetric sensitivity improved with repeat examination both within-and between-eyes at a given examination and also between-examinations - a finding of considerable ramification for the monitoring of the efficacy of therapeutic intervention. We have also shown that forward light scatter arising from media opacities causes an apparent diffuse depression of the visual field in primary open angle glaucoma and to produce an apparent reduction in the size and/or depth of focal visual loss.
Datblygu gweithdrefnau ystadegol ar gyfer adnabod colli maes gweledol cynhalgar: Mae'r amrywioldeb tymor byr a'r hirdymor yn rhwystro adnabod colli maes gweledol cynyddol mewn dadansoddiad maes gweledol cyfresol. Dros nifer o flynyddoedd mae gwaith cydweithredol yng Nghanada gyda John Flanagan ym Mhrifysgolion Waterloo a Toronto a Graham Trope ym Mhrifysgol Toronto wedi arwain at ddatblygu model mathemategol ar gyfer dosbarthiad pwynt sensitifrwydd mewn normalau, gorbwysedd llygaid a glawcoma ongl agored cynradd yn seiliedig ar atchweliad polynomial a lluosog.
Perimetry awtomataidd tonfedd byr: Ar hyn o bryd mae llawer o ddiddordeb yn canolbwyntio ar y defnydd o perimetreg awtomataidd tonfedd fer (SWAP) ar gyfer canfod colli maes gweledol yn gynnar mewn glawcoma ongl agored cynradd. Mae pum grŵp ymchwil, gan gynnwys fy hun, bellach wedi awgrymu y gall colli maes gweledol SWS ddigwydd mewn glawcoma ongl agored cynradd cyn colli maes gwyn-ar-wyn confensiynol (W-W) a gallant arddangos dilyniant cyn hynny pan gaiff ei gofnodi gyda perimetry W-W confensiynol. Fodd bynnag, rydym wedi dangos bod amrywioldeb arferol rhwng y pwnc yn fwy nag ar gyfer perimetry W-W confensiynol. Yn ogystal, rydym hefyd wedi adrodd bod yr amrywioldeb o fewn y pwnc a'r amrywioldeb rhwng prawf hefyd yn fwy ar gyfer SWAP nag ar gyfer perimetry W-W. Mae'r terfynau hyder uwch ar gyfer SWAP yn rhwystro canfod annormaledd tra bod yr amrywioldeb mwy o fewn y prawf a'r prawf yn rhwystro canfod colli maes sy'n datblygu. Mae'r dechneg yn ei fformat presennol felly yn rhy anodd ac o ganlyniad nid yw wedi cael ei sefydlu fel rhan arferol o ymarfer offthalmolegol.
Mae'r berthynas rhwng ymddangosiad pen y nerf optig mewn glawcoma ongl agored cynradd ac ymddangosiad y maes gweledol confensiynol W-W yn wan. Mae'r diffyg cydberthynas yn awgrymu newid strwythurol cyn colli swyddogaethol. Mae tomograffeg cydlyniant optegol yn dechneg ddelweddu a gyflwynwyd yn ddiweddar sy'n gallu perfformio delweddu trawsdoriadol neu tomograffig. Mae'r dechneg yn seiliedig ar interferometreg cydlyniant isel a ddefnyddir i fesur amser oedi adlais golau a adlewyrchir o'r gwahanol nodweddion microstrwythurol sy'n cael eu hymchwilio. Mae'r dechnoleg yn gallu mesur trwch haen ffibr nerf retinol (RNFL). Rydym wedi datblygu methodoleg sy'n cynhyrchu mesur atgynhyrchadwy o'r RNFL mewn glawcoma. Ar hyn o bryd mae astudiaethau sy'n ymwneud â strwythur â swyddogaeth ar y gweill sy'n cynnwys dadansoddiad RNFL, tomograffeg pen nerf optig, perimetreg gwyn-ar-wyn confensiynol SWAP a Perimetreg Dyblu Amledd.
The prevalence and aetiology of visual field loss associated with anticonvulsant medicine: The anti-epileptic drug vigabatrin is an effective and well-tolerated drug used for the treatment of partial seizures in adults and children. A typical pattern of visual field loss is associated with vigabatrin; sef, a bilateral constriction. We have shown that within the central field, only, (i.e. out to 30 from fixation) the vigabatrin-attributed visual field loss can take on a variety of forms. In mild and moderate cases, the defect manifests as a steeply bordered, crescent-like loss in the nasal field which typically extend superiorly and inferiorly with a preservation of the temporal field. In severe cases, the defect is steeply bordered and concentric to within approximately 15 from fixation. In early cases, the defect can happen inferior-nasally. Mae'r golled maes yn asymptomatig yn y mwyafrif o gleifion. Yn ôl pob tebyg, mae cadwraeth aciwtedd gweledol canolog da ynghyd â chynildeb rhesymol o'r maes amserol yn galluogi'r claf i gynnal gweithgareddau arferol bywyd bob dydd heb anhawster amlwg. Mae ymchwil ar y cyd â Graham Harding ym Mhrifysgol Aston wedi dangos bod rhai annormaleddau electroffisiolegol gweledol yr ERG (osgled ffotopig a-b, hwyrni tonnau a hwyrni OP2) yn gysylltiedig yn sylweddol â therapi vigabatrin cyfredol. Rydym hefyd wedi dangos bod latency amodau y don a o dan 30 Hz, osgled yr ymateb 30Hz a-b a hwyrni y don ffotopig a yn gysylltiedig yn sylweddol â phresenoldeb colli maes gweledol difrifol.
Cyllid
Gwyllt, £60,000, Perimetreg Sŵn Deinamig Cronfa bartneriaeth Caerdydd, 2010-2012
Bywgraffiad
Cymwysterau Addysgol a Phroffesiynol
- 2012 DSc, Prifysgol Dinas Llundain
- 1977 - 2001: PhD, Seicoffiseg glinigol pobl ifanc â nam ar eu golwg, Prifysgol Aston
- 1976 - 1977: MSc, Dulliau Arholiad Offthalmig, Prifysgol Aston
- 1975 FBOA, FSMC (bellach FCOptom)
- 1971 -1974 BSc (Anrh) Opteg Offthalmig, Prifysgol y Ddinas
Anrhydeddau a dyfarniadau
- 2013: Cymdeithas yr Optometryddion (AOP), Enwebwyd ar gyfer Darlithydd y Flwyddyn
- 2013: Gwobr Bywyd Myfyrwyr Cyfoethogi Prifysgol Caerdydd, wedi'i henwebu ar gyfer yr Athro Mwyaf Effeithiol ac ar gyfer yr Aelod Staff Mwyaf Dyrchafol
Safleoedd academaidd blaenorol
- 2010 - presennol: Athro, Ysgol Optometreg a Gwyddorau Golwg Caerdydd, Prifysgol Caerdydd
- 1996 - 2000 Uwch Ddarlithydd, Adran Gwyddorau Gweledigaeth, Prifysgol Aston
- 1980 - 1996 Darlithydd, Adran Gwyddorau Gweledigaeth, Prifysgol Aston.
- 2013 - presennol Darlithydd Gwadd, Adran Opteg ac Optometreg, Ysgol Uwchradd y Brifysgol, Brwsel
- 1996 - 2000. Gwyddonydd Gweledol Ymgynghorol Anrhydeddus, Ymddiriedolaeth GIG Birmingham Heartlands a Solihull (Addysgu)
- 1994 - 2000. Gwyddonydd Clinigol er Anrhydedd. Canolfan Llygaid Birmingham a Chanolbarth Lloegr, Ymddiriedolaeth GIG Ysbytai y Ddinas
- 1991 - 1998. Athro Cyswllt Gwadd Cynorthwyol, Prifysgol Waterloo, Ontario, Canada.
Pwyllgorau ac adolygu
- 2010 - presennol: Aelod o'r Pwyllgor Ymchwil
- 2014 - presennol Bwrdd Cyfarwyddwyr
- 2014 - presennol Pwyllgor Moeseg Archwilio Ymchwil Ysgolion
Pwyllgorau/Aelodaeth Allanol
- 2000 - presennol Pwyllgor Optometrig Cymru
- 1988 - presennol: Aelod o'r Gymdeithas Ymchwil mewn Golwg ac Offthalmoleg (ARVO)
- 2008 - presennol: Aelod o'r Gymdeithas Glawcoma Ewropeaidd
- 2007 - presennol: Aelod o Gymdeithas Glawcoma y Deyrnas Unedig ac Iwerddon
- 2002 - presennol Cymdeithas Glawcoma Optometrig.
- 1986 - 2010 Cymdeithas Delweddu a Perimetrig (Llywydd 1996-2000).