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Yr Athro Alun Davies
FRS
Timau a rolau for Alun Davies
Athro Anrhydeddus
Ysgol y Biowyddorau
Athro Emeritws
Ysgol y Biowyddorau
Trosolwyg
Rydym yn defnyddio amrywiaeth eang o ddulliau cellular, moleciwlaidd a thrawsgenig i ddeall rheoleiddio goroesiad niwronau a thwf ac ymhelaethu axons a dendrites yn y system nerfol fertebratau sy'n datblygu.
Cyhoeddiad
2021
- Carriba, P. and Davies, A. M. 2021. Signalling pathways mediating the effects of CD40-activated CD40L reverse signalling on inhibitory medium spiny neuron Neurite growth. Cells 10(4), article number: 829. (10.3390/cells10040829)
- Howard, L., Wyatt, S. and Davies, A. M. 2021. Neuregulin-4 contributes to the establishment of cutaneous sensory innervation. Developmental Neurobiology 81(2), pp. 139-148. (10.1002/dneu.22803)
- Paramo, B., Bachmann, S. O., Baudouin, S. J., Martinez Garay, I. and Davies, A. M. 2021. Neuregulin-4 is required for maintaining soma size of pyramidal neurons in the motor cortex. eNeuro 8(1), article number: 0288-20.2021. (10.1523/ENEURO.0288-20.2021)
- Carriba, P. and Davies, A. M. 2021. How CD40L reverse signaling regulates axon and dendrite growth. Cellular and Molecular Life Sciences 78, pp. 1065-1083. (10.1007/s00018-020-03563-2)
- Carriba, P. and Davies, A. M. 2021. CD40L/CD40 bidirectional signaling is a major regulator of neuronal morphology in the developing nervous system. Neural Regeneration Research 16(8), pp. 1539-1541. (10.4103/1673-5374.303025)
2020
- Horton, A. R. and Davies, A. M. 2020. Initial axon growth rate from embryonic sensory neurons is correlated with birth date. Developmental Neurobiology 80(3-4), pp. 126-131. (10.1002/dneu.22743)
- Carriba, P., Wyatt, S. and Davies, A. M. 2020. CD40L Reverse signaling influences dendrite spine morphology and expression of PSD-95 and Rho small GTPases. Frontiers in Cell and Developmental Biology 8, article number: 254. (10.3389/fcell.2020.00254)
2019
- Calhan, O. Y., Wyatt, S. and Davies, A. M. 2019. CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation. Developmental Neurobiology 79(11-12), pp. 949-962. (10.1002/dneu.22735)
- Howard, L., McWilliams, T. G., Wyatt, S. and Davies, A. M. 2019. CD40 forward signalling is a physiological regulator of early sensory axon growth. Development 146(18), article number: dev176495. (10.1242/dev.176495)
- Paramo, B., Wyatt, S. and Davies, A. M. 2019. Neuregulin-4 is required for the growth and elaboration of striatal medium spiny neuron dendrites. Journal of Neuropathology and Experimental Neurology 78(8), pp. 725-734. (10.1093/jnen/nlz046)
- Erice, C., Calhan, O. Y., Kisiswa, L., Wyatt, S. and Davies, A. M. 2019. Regional differences in the contributions of TNF reverse and forward signaling to the establishment of sympathetic innervation. Developmental Neurobiology 79(4), pp. 317-334. (10.1002/dneu.22680)
2018
- Howard, L., Wosnitzka, E., Okakpu, D., White, M. A., Wyatt, S. and Davies, A. M. 2018. TWE-PRIL reverse signaling suppresses sympathetic axon growth and tissue innervation. Development 145(22), article number: dev165936. (10.1242/dev.165936)
- Pellegrinelli, V. et al. 2018. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. Nature Communications 9, article number: 4974. (10.1038/s41467-018-07453-x)
- Paramo, B., Wyatt, S. and Davies, A. 2018. An essential role for neuregulin-4 in the growth and elaboration of developing neocortical pyramidal dendrites. Experimental Neurology 302, pp. 85-92. (10.1016/j.expneurol.2018.01.002)
2017
- Carriba, P. and Davies, A. M. 2017. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. eLife 6, article number: e30442. (10.7554/eLife.30442)
- McWilliams, T. G., Howard, L., Wyatt, S. and Davies, A. M. 2017. TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. Experimental Neurology 298, pp. 97-103. (10.1016/j.expneurol.2017.09.007)
- Kisiswa, L., Erice Jurecky, C., Ferron, L., Wyatt, S., Osório, C., Dolphin, A. C. and Davies, A. M. 2017. T-type Ca 2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling. Open Biology 7(1), article number: 160288. (10.1098/rsob.160288)
2016
- O'Keeffe, G. et al. 2016. Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. Neural Development 11, article number: 4. (10.1186/s13064-016-0060-3)
2015
- Vizard, T. N., Newton, M., Howard, L., Wyatt, S. L. and Davies, A. M. 2015. ERK signaling mediates CaSR-promoted axon growth. Neuroscience Letters 603, pp. 77-83. (10.1016/j.neulet.2015.07.019)
- McWilliams, T. G., Howard, L., Wyatt, S. and Davies, A. M. 2015. Regulation of autocrine signaling in subsets of sympathetic neurons has regional effects on tissue innervation. Cell Reports 10(9), pp. 1443-1449. (10.1016/j.celrep.2015.02.016)
2014
- Osório, C. R., Chacon Fernandez, P. J., White, M., Kisiswa, L., Wyatt, S. L., Rodríguez-Tébar, A. and Davies, A. M. 2014. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Molecular and Cellular Neuroscience 59, pp. 24-36. (10.1016/j.mcn.2014.01.002)
2013
- Osorio, C. R., Chacon Fernandez, P., Kisiswa, L., White, M., Wyatt, S. L., Rodriguez-Tebar, A. and Davies, A. M. 2013. Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development 140(23), pp. 4751-4762. (10.1242/dev.101378)
- Kisiswa, L., Osório, C. R., Erice Jurecky, C., Vizard, T. N., Wyatt, S. L. and Davies, A. M. 2013. TNFα reverse signaling promotes sympathetic axon growth and target innervation. Nature Neuroscience 16(7), pp. 865-873. (10.1038/nn.3430)
- Howard, L., Wyatt, S. L., Nagappan, G. and Davies, A. M. 2013. ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75(NTR)-dependent mechanism. Development 140(10), pp. 2108-2117. (10.1242/dev.085266)
- Gatto, G., Dudanova, I., Suetterlin, P., Davies, A. M., Drescher, U., Bixby, J. L. and Klein, R. 2013. Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling. Journal of Neuroscience 33(12), pp. 5399-5410. (10.1523/JNEUROSCI.4707-12.2013)
- Gutierrez, H., Kisiswa, L., O'Keeffe, G. W., Smithen, M. J., Wyatt, S. L. and Davies, A. M. 2013. Regulation of neurite growth by tumour necrosis superfamily member RANKL. Open Biology 3(1), article number: 120150. (10.1098/rsob.120150)
- Davies, A. M. 2013. Regulation of neuronal survival by neurotrophins in the developing peripheral nervous system. In: Rubenstein, J. L. R. and Rakic, P. eds. Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS., Vol. 1. Amsterdam: Elsevier, pp. 303-311.
2011
- Gutierrez, H. and Davies, A. M. 2011. Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends in Neurosciences 34(6), pp. 316-325. (10.1016/j.tins.2011.03.001)
- Wyatt, S. L., Spori, B., Vizard, T. N. and Davies, A. M. 2011. Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation. Neural Development 6, article number: 18. (10.1186/1749-8104-6-18)
2010
- Moubarak, R. et al. 2010. The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. Journal of Neuroscience 30(17), pp. 6094-6105. (10.1523/JNEUROSCI.0537-10.2010)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
2009
- Gavalda, N., Gutierrez, H. and Davies, A. M. 2009. Developmental switch in NF-kappa B signalling required for neurite growth. Development 136(20), pp. 3405-3412. (10.1242/dev.035295)
- Franklin, S. L., Davies, A. M. and Wyatt, S. L. 2009. Macrophage stimulating protein is a neurotrophic factor for a sub-population of adult nociceptive sensory neurons. Molecular and Cellular Neuroscience 41(2), pp. 175-185. (10.1016/j.mcn.2009.02.009)
- Gavalda, N., Gutierrez, H. and Davies, A. M. 2009. Developmental regulation of sensory neurite growth by the tumor necrosis factor superfamily member LIGHT. Journal of Neuroscience 29(6), pp. 1599-1607. (10.1523/JNEUROSCI.3566-08.2009)
- Davies, A. M. 2009. Extracellular signals regulating sympathetic neuron survival and target innervation during development. Autonomic Neuroscience-Basic & Clinical 151(1), pp. 39-45. (10.1016/j.autneu.2009.07.011)
2008
- Gutierrez, H., O'Keeffe, G., Gavaldà, N., Gallagher, D. and Davies, A. M. 2008. Nuclear factor κB signaling either stimulates or inhibits neurite growth depending on the phosphorylation Status of p65/RelA. Journal of Neuroscience 28(33), pp. 8246-8256. (10.1523/JNEUROSCI.1941-08.2008)
- Bishop, T. et al. 2008. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Molecular and Cellular Biology 28(10), pp. 3386-3400. (10.1128/MCB.02041-07)
- Andres, R., Herraez-Baranda, L. A., Thompson, J., Wyatt, S. L. and Davies, A. M. 2008. Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. Neuroscience Letters 431(3), pp. 241-246. (10.1016/j.neulet.2007.11.045)
- O'Keeffe, G., Gutierrez, H., Pandolfi, P. P., Riccardi, C. and Davies, A. M. 2008. NGF-promoted axon growth and target innervation requires GITRL-GITR signaling. Nature Neuroscience 11(2), pp. 135-142. (10.1038/nn2034)
- Vizard, T. N., O'Keeffe, G. W., Gutierrez, H., Kos, C. H., Riccardi, D. and Davies, A. M. 2008. Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor. Nature Neuroscience 11(3), pp. 285-291. (10.1038/nn2044)
- Andres, R., Herraez-Baranda, L. A., Thompson, J., Wyatt, S. L. and Davies, A. M. 2008. Regulation of developing sympathetic neuron phenotype by endogenous NGF and NT3. Neuroscience Letters 431(3), pp. 241-246. (10.1016/j.neulet.2007.11.045)
- Acosta, C. and Davies, A. M. 2008. Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons. Journal of Neuroscience Research 86(5), pp. 1077-1086. (10.1002/jnr.21565)
- Davies, A. M. 2008. Neurotrophins giveth and they taketh away. Nature Neuroscience 11(6), pp. 627-628. (10.1038/nn0608-627)
- Pape, M., Doxakis, E., Duong, C. V., Davies, A. M., Geissen, M. and Rohrer, H. 2008. A function for the calponin family member NP25 in neurite outgrowth. Developmental Biology 321(2), pp. 434-443. (10.1016/j.ydbio.2008.07.001)
- Doxakis, E., Howard, L., Rohrer, H. and Davies, A. M. 2008. Hand transcription factors are required for postnatal sympathetic neuron survival. EMBO Reports 9(10), pp. 1041-1047. (10.1038/embor.2008.161)
2006
- Hefti, F. F., Rosenthal, A., Walicke, P. A., Wyatt, S. L., Vergara, G., Shelton, S. and Davies, A. M. 2006. Novel class of pain drugs based on antagonism of NGF. Trends in Pharmacological Sciences 27(2), pp. 85-91. (10.1016/j.tips.2005.12.001)
2005
- Gutierrez, H., Hale, V. A., Dolcet, X. and Davies, A. M. 2005. NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS. Development, pp. 1713-1726. (10.1242/dev.01702)
- Thomas, K. L. and Davies, A. 2005. Neurotrophins: a ticket to ride for BDNF. Current Biology 15(7), pp. R262-R264. (10.1016/j.cub.2005.03.023)
2004
- Davies, A. M., Doxakis, E. and Huang, E. 2004. Homeodomain-interacting protein kinase-2 (HIPK2) regulates apoptosis in developing sensory and sympathetic neurons. Current Biology, pp. 1761-1765. (10.1016/j.cub.2004.09.050)
2003
- Forgie, A., Wyatt, S. L., Correll, P. H. and Davies, A. M. 2003. Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons. Development 130(5), pp. 995-1002. (10.1242/dev.00329)
2001
- Barker, V., Middleton, G., Davey, F. and Davies, A. M. 2001. TNFalpha contributes to the death of NGF-dependent neurons during development. Nature Neuroscience, pp. 1194-1198. (10.1038/nn755)
- Andres, R., Forgie, A., Wyatt, S. L., Chen, Q., de Sauvage, F. J. and Davies, A. M. 2001. Multiple effects of artemin on sympathetic neurone generation, survival and growth. Development 128(19), pp. 3685-3695.
- Orike, N., Middleton, G., Borthwick, E., Buchman, V. L., Cowen, T. and Davies, A. M. 2001. Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons. Journal of cell biology, pp. 995-1005. (10.1083/jcb.200101068)
- Middleton, G., Wyatt, S. L., Ninkina, N. and Davies, A. M. 2001. Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. Development 128(3), pp. 447-457.
- Alonzi, T. et al. 2001. Role of STAT3 and PI 3-Kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Molecular and Cellular Neuroscience 18(3), pp. 270-282. (10.1006/mcne.2001.1018)
2000
- Middleton, G. et al. 2000. Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. Journal of cell biology 148(2), pp. 325-332. (10.1083/jcb.148.2.325)
- Middleton, G., Wyatt, S. L., Cox, A., Korsmeyer, S. and Davies, A. 2000. Differences in Bcl-2- and Bax-independent function in regulating apoptosis in sensory neuron populations. European Journal of Neuroscience 12(3), pp. 819-827. (10.1046/j.1460-9568.2000.00966.x)
- Forgie, A., Kuehnel, F., Wyatt, S. L. and Davies, A. M. 2000. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. European Journal of Neuroscience 12(2), pp. 670-676. (10.1046/j.1460-9568.2000.00951.x)
Articles
- Carriba, P. and Davies, A. M. 2021. Signalling pathways mediating the effects of CD40-activated CD40L reverse signalling on inhibitory medium spiny neuron Neurite growth. Cells 10(4), article number: 829. (10.3390/cells10040829)
- Howard, L., Wyatt, S. and Davies, A. M. 2021. Neuregulin-4 contributes to the establishment of cutaneous sensory innervation. Developmental Neurobiology 81(2), pp. 139-148. (10.1002/dneu.22803)
- Paramo, B., Bachmann, S. O., Baudouin, S. J., Martinez Garay, I. and Davies, A. M. 2021. Neuregulin-4 is required for maintaining soma size of pyramidal neurons in the motor cortex. eNeuro 8(1), article number: 0288-20.2021. (10.1523/ENEURO.0288-20.2021)
- Carriba, P. and Davies, A. M. 2021. How CD40L reverse signaling regulates axon and dendrite growth. Cellular and Molecular Life Sciences 78, pp. 1065-1083. (10.1007/s00018-020-03563-2)
- Carriba, P. and Davies, A. M. 2021. CD40L/CD40 bidirectional signaling is a major regulator of neuronal morphology in the developing nervous system. Neural Regeneration Research 16(8), pp. 1539-1541. (10.4103/1673-5374.303025)
- Horton, A. R. and Davies, A. M. 2020. Initial axon growth rate from embryonic sensory neurons is correlated with birth date. Developmental Neurobiology 80(3-4), pp. 126-131. (10.1002/dneu.22743)
- Carriba, P., Wyatt, S. and Davies, A. M. 2020. CD40L Reverse signaling influences dendrite spine morphology and expression of PSD-95 and Rho small GTPases. Frontiers in Cell and Developmental Biology 8, article number: 254. (10.3389/fcell.2020.00254)
- Calhan, O. Y., Wyatt, S. and Davies, A. M. 2019. CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation. Developmental Neurobiology 79(11-12), pp. 949-962. (10.1002/dneu.22735)
- Howard, L., McWilliams, T. G., Wyatt, S. and Davies, A. M. 2019. CD40 forward signalling is a physiological regulator of early sensory axon growth. Development 146(18), article number: dev176495. (10.1242/dev.176495)
- Paramo, B., Wyatt, S. and Davies, A. M. 2019. Neuregulin-4 is required for the growth and elaboration of striatal medium spiny neuron dendrites. Journal of Neuropathology and Experimental Neurology 78(8), pp. 725-734. (10.1093/jnen/nlz046)
- Erice, C., Calhan, O. Y., Kisiswa, L., Wyatt, S. and Davies, A. M. 2019. Regional differences in the contributions of TNF reverse and forward signaling to the establishment of sympathetic innervation. Developmental Neurobiology 79(4), pp. 317-334. (10.1002/dneu.22680)
- Howard, L., Wosnitzka, E., Okakpu, D., White, M. A., Wyatt, S. and Davies, A. M. 2018. TWE-PRIL reverse signaling suppresses sympathetic axon growth and tissue innervation. Development 145(22), article number: dev165936. (10.1242/dev.165936)
- Pellegrinelli, V. et al. 2018. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. Nature Communications 9, article number: 4974. (10.1038/s41467-018-07453-x)
- Paramo, B., Wyatt, S. and Davies, A. 2018. An essential role for neuregulin-4 in the growth and elaboration of developing neocortical pyramidal dendrites. Experimental Neurology 302, pp. 85-92. (10.1016/j.expneurol.2018.01.002)
- Carriba, P. and Davies, A. M. 2017. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. eLife 6, article number: e30442. (10.7554/eLife.30442)
- McWilliams, T. G., Howard, L., Wyatt, S. and Davies, A. M. 2017. TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. Experimental Neurology 298, pp. 97-103. (10.1016/j.expneurol.2017.09.007)
- Kisiswa, L., Erice Jurecky, C., Ferron, L., Wyatt, S., Osório, C., Dolphin, A. C. and Davies, A. M. 2017. T-type Ca 2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling. Open Biology 7(1), article number: 160288. (10.1098/rsob.160288)
- O'Keeffe, G. et al. 2016. Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. Neural Development 11, article number: 4. (10.1186/s13064-016-0060-3)
- Vizard, T. N., Newton, M., Howard, L., Wyatt, S. L. and Davies, A. M. 2015. ERK signaling mediates CaSR-promoted axon growth. Neuroscience Letters 603, pp. 77-83. (10.1016/j.neulet.2015.07.019)
- McWilliams, T. G., Howard, L., Wyatt, S. and Davies, A. M. 2015. Regulation of autocrine signaling in subsets of sympathetic neurons has regional effects on tissue innervation. Cell Reports 10(9), pp. 1443-1449. (10.1016/j.celrep.2015.02.016)
- Osório, C. R., Chacon Fernandez, P. J., White, M., Kisiswa, L., Wyatt, S. L., Rodríguez-Tébar, A. and Davies, A. M. 2014. Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL. Molecular and Cellular Neuroscience 59, pp. 24-36. (10.1016/j.mcn.2014.01.002)
- Osorio, C. R., Chacon Fernandez, P., Kisiswa, L., White, M., Wyatt, S. L., Rodriguez-Tebar, A. and Davies, A. M. 2013. Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development. Development 140(23), pp. 4751-4762. (10.1242/dev.101378)
- Kisiswa, L., Osório, C. R., Erice Jurecky, C., Vizard, T. N., Wyatt, S. L. and Davies, A. M. 2013. TNFα reverse signaling promotes sympathetic axon growth and target innervation. Nature Neuroscience 16(7), pp. 865-873. (10.1038/nn.3430)
- Howard, L., Wyatt, S. L., Nagappan, G. and Davies, A. M. 2013. ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75(NTR)-dependent mechanism. Development 140(10), pp. 2108-2117. (10.1242/dev.085266)
- Gatto, G., Dudanova, I., Suetterlin, P., Davies, A. M., Drescher, U., Bixby, J. L. and Klein, R. 2013. Protein Tyrosine Phosphatase Receptor Type O Inhibits Trigeminal Axon Growth and Branching by Repressing TrkB and Ret Signaling. Journal of Neuroscience 33(12), pp. 5399-5410. (10.1523/JNEUROSCI.4707-12.2013)
- Gutierrez, H., Kisiswa, L., O'Keeffe, G. W., Smithen, M. J., Wyatt, S. L. and Davies, A. M. 2013. Regulation of neurite growth by tumour necrosis superfamily member RANKL. Open Biology 3(1), article number: 120150. (10.1098/rsob.120150)
- Gutierrez, H. and Davies, A. M. 2011. Regulation of neural process growth, elaboration and structural plasticity by NF-κB. Trends in Neurosciences 34(6), pp. 316-325. (10.1016/j.tins.2011.03.001)
- Wyatt, S. L., Spori, B., Vizard, T. N. and Davies, A. M. 2011. Selective regulation of nerve growth factor expression in developing cutaneous tissue by early sensory innervation. Neural Development 6, article number: 18. (10.1186/1749-8104-6-18)
- Moubarak, R. et al. 2010. The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. Journal of Neuroscience 30(17), pp. 6094-6105. (10.1523/JNEUROSCI.0537-10.2010)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
- Gavalda, N., Gutierrez, H. and Davies, A. M. 2009. Developmental switch in NF-kappa B signalling required for neurite growth. Development 136(20), pp. 3405-3412. (10.1242/dev.035295)
- Franklin, S. L., Davies, A. M. and Wyatt, S. L. 2009. Macrophage stimulating protein is a neurotrophic factor for a sub-population of adult nociceptive sensory neurons. Molecular and Cellular Neuroscience 41(2), pp. 175-185. (10.1016/j.mcn.2009.02.009)
- Gavalda, N., Gutierrez, H. and Davies, A. M. 2009. Developmental regulation of sensory neurite growth by the tumor necrosis factor superfamily member LIGHT. Journal of Neuroscience 29(6), pp. 1599-1607. (10.1523/JNEUROSCI.3566-08.2009)
- Davies, A. M. 2009. Extracellular signals regulating sympathetic neuron survival and target innervation during development. Autonomic Neuroscience-Basic & Clinical 151(1), pp. 39-45. (10.1016/j.autneu.2009.07.011)
- Gutierrez, H., O'Keeffe, G., Gavaldà, N., Gallagher, D. and Davies, A. M. 2008. Nuclear factor κB signaling either stimulates or inhibits neurite growth depending on the phosphorylation Status of p65/RelA. Journal of Neuroscience 28(33), pp. 8246-8256. (10.1523/JNEUROSCI.1941-08.2008)
- Bishop, T. et al. 2008. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Molecular and Cellular Biology 28(10), pp. 3386-3400. (10.1128/MCB.02041-07)
- Andres, R., Herraez-Baranda, L. A., Thompson, J., Wyatt, S. L. and Davies, A. M. 2008. Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. Neuroscience Letters 431(3), pp. 241-246. (10.1016/j.neulet.2007.11.045)
- O'Keeffe, G., Gutierrez, H., Pandolfi, P. P., Riccardi, C. and Davies, A. M. 2008. NGF-promoted axon growth and target innervation requires GITRL-GITR signaling. Nature Neuroscience 11(2), pp. 135-142. (10.1038/nn2034)
- Vizard, T. N., O'Keeffe, G. W., Gutierrez, H., Kos, C. H., Riccardi, D. and Davies, A. M. 2008. Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor. Nature Neuroscience 11(3), pp. 285-291. (10.1038/nn2044)
- Andres, R., Herraez-Baranda, L. A., Thompson, J., Wyatt, S. L. and Davies, A. M. 2008. Regulation of developing sympathetic neuron phenotype by endogenous NGF and NT3. Neuroscience Letters 431(3), pp. 241-246. (10.1016/j.neulet.2007.11.045)
- Acosta, C. and Davies, A. M. 2008. Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons. Journal of Neuroscience Research 86(5), pp. 1077-1086. (10.1002/jnr.21565)
- Davies, A. M. 2008. Neurotrophins giveth and they taketh away. Nature Neuroscience 11(6), pp. 627-628. (10.1038/nn0608-627)
- Pape, M., Doxakis, E., Duong, C. V., Davies, A. M., Geissen, M. and Rohrer, H. 2008. A function for the calponin family member NP25 in neurite outgrowth. Developmental Biology 321(2), pp. 434-443. (10.1016/j.ydbio.2008.07.001)
- Doxakis, E., Howard, L., Rohrer, H. and Davies, A. M. 2008. Hand transcription factors are required for postnatal sympathetic neuron survival. EMBO Reports 9(10), pp. 1041-1047. (10.1038/embor.2008.161)
- Hefti, F. F., Rosenthal, A., Walicke, P. A., Wyatt, S. L., Vergara, G., Shelton, S. and Davies, A. M. 2006. Novel class of pain drugs based on antagonism of NGF. Trends in Pharmacological Sciences 27(2), pp. 85-91. (10.1016/j.tips.2005.12.001)
- Gutierrez, H., Hale, V. A., Dolcet, X. and Davies, A. M. 2005. NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS. Development, pp. 1713-1726. (10.1242/dev.01702)
- Thomas, K. L. and Davies, A. 2005. Neurotrophins: a ticket to ride for BDNF. Current Biology 15(7), pp. R262-R264. (10.1016/j.cub.2005.03.023)
- Davies, A. M., Doxakis, E. and Huang, E. 2004. Homeodomain-interacting protein kinase-2 (HIPK2) regulates apoptosis in developing sensory and sympathetic neurons. Current Biology, pp. 1761-1765. (10.1016/j.cub.2004.09.050)
- Forgie, A., Wyatt, S. L., Correll, P. H. and Davies, A. M. 2003. Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons. Development 130(5), pp. 995-1002. (10.1242/dev.00329)
- Barker, V., Middleton, G., Davey, F. and Davies, A. M. 2001. TNFalpha contributes to the death of NGF-dependent neurons during development. Nature Neuroscience, pp. 1194-1198. (10.1038/nn755)
- Andres, R., Forgie, A., Wyatt, S. L., Chen, Q., de Sauvage, F. J. and Davies, A. M. 2001. Multiple effects of artemin on sympathetic neurone generation, survival and growth. Development 128(19), pp. 3685-3695.
- Orike, N., Middleton, G., Borthwick, E., Buchman, V. L., Cowen, T. and Davies, A. M. 2001. Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons. Journal of cell biology, pp. 995-1005. (10.1083/jcb.200101068)
- Middleton, G., Wyatt, S. L., Ninkina, N. and Davies, A. M. 2001. Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. Development 128(3), pp. 447-457.
- Alonzi, T. et al. 2001. Role of STAT3 and PI 3-Kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Molecular and Cellular Neuroscience 18(3), pp. 270-282. (10.1006/mcne.2001.1018)
- Middleton, G. et al. 2000. Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons. Journal of cell biology 148(2), pp. 325-332. (10.1083/jcb.148.2.325)
- Middleton, G., Wyatt, S. L., Cox, A., Korsmeyer, S. and Davies, A. 2000. Differences in Bcl-2- and Bax-independent function in regulating apoptosis in sensory neuron populations. European Journal of Neuroscience 12(3), pp. 819-827. (10.1046/j.1460-9568.2000.00966.x)
- Forgie, A., Kuehnel, F., Wyatt, S. L. and Davies, A. M. 2000. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. European Journal of Neuroscience 12(2), pp. 670-676. (10.1046/j.1460-9568.2000.00951.x)
Book sections
- Davies, A. M. 2013. Regulation of neuronal survival by neurotrophins in the developing peripheral nervous system. In: Rubenstein, J. L. R. and Rakic, P. eds. Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing CNS and PNS., Vol. 1. Amsterdam: Elsevier, pp. 303-311.
Ymchwil
Rydym yn defnyddio amrywiaeth o ddulliau i ymchwilio i sut mae moleciwlau signalau wedi'u secretu yn effeithio ar gynhyrchu a goroesi niwronau a dylanwadu ar sefydlu ac addasu eu cysylltiadau yn y system nerfol fertebratau sy'n datblygu. Rydym wedi sefydlu systemau diwylliant celloedd sydd wedi'u nodweddu'n dda i ganfod rolau'r ffactorau hyn ar gamau diffiniedig mewn niwroblast a datblygiad niwronau ac rydym yn dechnoleg drawsgenig i ymchwilio i ganlyniadau treigladau yn y genynnau sy'n amgodio'r ffactorau hyn, eu derbynyddion a moleciwlau rheoleiddio eraill. Mae gennym ddiddordeb cyfredol penodol yn rôl y ffactor necrosis tiwmor superfamily wrth reoleiddio twf prosesau niwral.
Aelodau'r tîm ymchwil
Grantiau ymchwil
Gwobr Uwch Ymchwilydd Ymddiriedolaeth Wellcome, 2014-2019, £2,043,743 'Uwchdeulu TNF ymlaen a gwrthdroi signalau mewn datblygiad niwral'.
Cyhoeddiadau dethol
- McWilliams, T., Howard, L. a Davies, A. M. 2015. Mae rheoleiddio signalau autocrine mewn is-setiau o niwronau sympathetig yn cael effeithiau rhanbarthol ar innervation meinwe. Adroddiadau Cell 10, tt. 1443-1449.
- Kisiswa, L., Osório, C., Erice, C., Vizard, T., Wyatt, S. a Davies, A. M. 2013. Mae signalau gwrthdro TNFα yn hyrwyddo twf echelin sympathetig a chynhyrfu targed. Natur Niwrowyddoniaeth 16, tt. 865-873.
- Osório, C., Chacon, P., Kisiswa, L., Gwyn, M., Wyatt, S., Rodiguez-Tebar, A. a Davies, A. M. 2013. Mae ffactor gwahaniaethu twf 5 yn rheoleiddiwr ffisiolegol allweddol ar gyfer twf dendrite yn ystod y datblygiad. Datblygiad 140, tt. 4751-4562.
- Howard, L., Wyatt, S., Nagappan G., a Davies, A. M. 2013. Mae ProNGF yn hyrwyddo twf niworit o is-set o niwronau NGF dibynnol gan fecanwaith dibynnol p75NTR. Datblygu140, tt. 2108-2117
- Gavalda, N., Gutierrez, H. a Davies, A. M. 2009. Newid datblygiadol mewn signalau NF-kB sy'n ofynnol ar gyfer twf niwrite. Datblygiad 136, tt.3405-3412Gutierrez, H., Hale, V. A., Dolcet, X. a Davies, A. M. 2005. Mae signalau NF-kB yn rheoleiddio twf prosesau niwral yn ystod y datblygiad. Datblygiad 132, tt. 1713-1726.
- O'Keeffe, G., Gutierrez, H., Pandolfi, P., Riccardi, C., Davies, A. M. 2008. Mae twf echelin a tharged NGF yn gofyn am signalau GITRL-GITR. Natur Niwrowyddoniaeth 11, tt. 135-142.
- Vizard, T. N., O'Keeffe, G., Gutierrez, H., Kos, C., Riccardi, D., Davies, A. M. 2008. Rheoleiddio twf echelinol a dendritig gan y derbynnydd calsiwm allgellog. Natur Niwrowyddoniaeth 11, tt. 285-291.
- Gutierrez, H., Dolcet, X., Tolcos M. a Davies, A. M. 2004. HGF yn ysgogi datblygiad dendrites niwronau pyramidaidd cortig. Datblygiad 131, tt. 3717-3726.
- Forgie, A., Wyatt, S., Correll, P. a Davies, A. M. 2003. Mae protein ysgogol macrophage (MSP) yn ffactor niwrotroffig newydd sy'n deillio o darged ar gyfer datblygu niwronau synhwyraidd a chydymdeimladol. Datblygiad 130, tt. 995-1002.
- Orike, N., Middleton, G., Buchman, V. L., Cowen, T. a Davies, A. M. 2001. Rôl proteinau PI 3-kinase, Akt a Bcl-2 wrth gynnal goroesiad niwronau sympathetig oedolion niwro-annibynnol ffactor niwrotroffig. Journal of Cell Biology 154, tt. 995-1005.
- Barker, V., Middleton, G., Davey, F. a Davies, A. M. 2001. Rôl ar gyfer TNFa wrth gyflymu apoptosis niwronau yn dilyn NGF amddifadedd Natur Niwrowyddoniaeth 4, tt. 1194-1198.
- Andres, R., Forgie, A., Wyatt, S., Chen, Q., de Sauvage, F. J. a Davies, A. M. 2001. Effeithiau lluosog artemin ar gynhyrchu niwronau sympathetig, goroesiad a thwf. Datblygiad 128, tt. 3685-3695.
- Enokido, Y., Wyatt, S. a Davies, A. M. 1999. Newidiadau datblygiadol yn ymateb niwronau trigeminal i niwronau trigeminal i niwrotroffinau: Dylanwad y dyddiad geni a'r amgylchedd ganglion. Datblygiad 126, tt. 4365-4373.
- Buchman, V. L., Adu, J., Pinõn, L. G. P., Ninkina, N. N. a Davies, A. M. 1998. Mae Persyn, synuclein nofel, yn dylanwadu ar gyfanrwydd rhwydwaith niwroffilament. Natur niwrowyddoniaeth 1, tt. 101-103.
- Maina, F., Hilton, M. C., Andres, R., Wyatt, S., Klein, R. a Davies, A. M. 1998. Rolau lluosog ar gyfer ffactor twf hepatocyte mewn datblygiad niwronau sympathetig. Niwron 20, tt. 835-846.
- Buj-Bello, A., Adu, J., Piñón, L. G. P., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V. L. a Davies, A. M. 1997. Mae ymatebolrwydd niwrturin yn gofyn am dderbynnydd GPI cysylltiedig ynghyd â'r kinase tyrosine derbynnydd Ret. Natur 387, tt. 721-724.
- Wyatt, S., Piñón, L. G. P., Ernfors, P. a Davies, A. M. 1997. Goroesi niwronau sympathetig a mynegiant TrkA mewn embryonau llygoden diffygiol NT3. EMBO Journal 16, tt. 3115-3123.
- Ninkina, N., Adu, J., Fischer, A., Piñón, L. G., Buchman, V. L. a Davies, A. M. 1996. Mynegiant a swyddogaeth amrywiadau TrkB wrth ddatblygu niwronau synhwyraidd. EMBO Journal 15, tt. 6385-6393.
- Buj-Bello, A., Buchman, V. L., Horton, A., Rosenthal, A. a Davies, A. M. 1995.
- Mae GDNF yn ffactor goroesi sy'n benodol i oedran ar gyfer niwronau synhwyraidd ac awtonomig. Niwron 15, tt. 821-828.
- Davies, A. M., Minichiello, L. a Klein, R. 1995. Newidiadau datblygiadol mewn signalau NT3 trwy TrkA a TrkB mewn niwronau embryonig. EMBO Journal 14, tt. 4482-4489.
- Davies, A. M., Lee, KF a Jaenisch, R. 1993. Mae gan niwronau trigeminal p75-ddiffygiol ymateb wedi'i newid i NGF ond nid i niwrotroffau eraill. Niwron 11, tt. 565-574.
- Allsopp, T., Robinson, M., Wyatt, S. a Davies, A. M. 1993. Mae mynegiant Ectopic TrkA yn cyfryngu ymateb goroesi NGF mewn niwronau synhwyraidd annibynnol NGF ond nid mewn niwronau parasympathetig. Journal of Cell Biology 123, tt. 1555-1566.
- Allsopp, T., Wyatt, S., Patterson, H. a Davies, A. M. 1993. Gall y bcl-2 proto-oncogene achub niwronau sy'n dibynnu ar ffactor niwrotroffig yn ddetholus rhag apoptosis. Cell 73, tt. 295-307.
- Buchman, V. I. a Davies, A. M. 1993. Mynegir gwahanol niwrotrophins ac maent yn gweithredu mewn dilyniant datblygiadol i hyrwyddo goroesiad niwronau synhwyraidd embryonig. Datblygiad 118, tt. 989-1001.
- Wright, E., Vogel, K. S. a Davies, A. M. 1992. Mae ffactorau niwrotroffig yn hyrwyddo aeddfedu datblygu niwronau synhwyraidd cyn iddynt ddod yn ddibynnol ar y ffactorau hyn ar gyfer goroesi. Niwron 9, tt. 139-150.
- Larmet, Y., Dolphin, A. C. a Davies, A. M. 1992. Mae calsiwm mewngellol yn rheoleiddio goroesiad niwronau synhwyraidd cynnar cyn iddynt ddod yn ddibynnol ar ffactorau niwrotroffig. Niwron 9, tt. 563-574.
- Vogel, K. S. a Davies, A. M. 1991. Mae hyd annibyniaeth ffactor niwrotroffig mewn niwronau synhwyraidd cynnar yn cael ei gyfateb â'r cwrs amser o innervation maes targed. Niwron 7, tt. 819-830.
- Wyatt, S., Shooter, E.M. a Davies, A. M. 1990. Mynegiant o'r genyn derbynnydd NGF mewn niwronau synhwyraidd a'u targedau cutaneous cyn ac yn ystod innervation. Niwron 4, tt. 421-427.
- Davies, A. M. 1989. Gwahaniaethau cynhenid yng nghyfradd twf ffibrau nerfau cynnar sy'n gysylltiedig â phellter targed. Natur 337, tt. 553-555.
- Davies, A. M., Bandtlow, C., Heumann, R., Korsching, S. Rohrer, H. a Thoenenen, H. 1987. Amseru a safle synthesis ffactor twf nerf wrth ddatblygu croen mewn perthynas â nerfol a mynegiant y derbynnydd. Natur 326, tt. 353-358.
- Lumsden, A.G.S. a Davies, A. M. 1986. Effaith cemotropig epitheliwm targed penodol yn y system nerfol mamalaidd sy'n datblygu. Natur 323, tt. 538-539.
- Davies, A. M., Thoenen, H. a Barde, Y.-A. 1986. Mae gwahanol ffactorau o'r system nerfol ganolog ac ymylol yn rheoleiddio goroesiad niwronau synhwyraidd. Natur 319, tt. 497-499.
- Lumsden, A. G. S. a Davies, A. M. 1983. Mae ffibrau nerf synhwyraidd cynharaf yn cael eu harwain at dargedau ymylol gan dynwyr heblaw ffactor twf nerfau. Natur 306, tt. 786-788.
Bywgraffiad
Gwnes i raddau mewn biocemeg a meddygaeth ym Mhrifysgol Lerpwl ac yna PhD mewn niwrobioleg ddatblygiadol ym Mhrifysgol Llundain. Rwyf wedi dal penodiadau fel Darlithydd, Uwch Ddarlithydd a Darllenydd mewn Niwrobioleg ym Mhrifysgol Llundain, Athro Niwrobioleg Ddatblygiadol yn Ysgol Bioleg Prifysgol St Andrews, Athro Ffisioleg yn Ysgol Filfeddygol Prifysgol Caeredin ac Is-lywydd Gweithredol Ymchwil yn Rinat Neuroscience Corp., UDA.
Cefais fy ethol yn Gymrawd Cymdeithas Frenhinol Caeredin yn 2000, Aelod o'r Sefydliad Bioleg Foleciwlaidd Ewropeaidd yn 2000, yn Gymrawd Academi'r Gwyddorau Meddygol yn 2010, yn Gymrawd Cymdeithas Ddysgedig Cymru yn 2011, yn Aelod o'r Academia Europaea yn 2011 ac yn Gymrawd y Gymdeithas Frenhinol yn 2011. Cefais fy mhenodi'n Athro Ymchwil Nodedig ym Mhrifysgol Caerdydd yn 2004 a deuthum yn Uwch Ymchwilydd Ymddiriedolaeth Wellcome yn 2014.
Contact Details
DAVIESALUN@caerdydd.ac.uk
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX