![Giuseppe Di Giovanni Professor BSc, MSc, PhD](https://profiles-cardiff.imgix.net/attachments/6401?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Giuseppe Di Giovanni
(e/fe)
Professor BSc, MSc, PhD
Athro Anrhydeddus
Ysgol y Biowyddorau
Trosolwyg
Trosolwg ymchwil
Mae astudiaethau yn Labordy'r Athro Giuseppe Di Giovanni yn cynnwys:-
- Habenula ochrol mewn caethiwed ac iselder nicotin.
- System serotoninergic mewn epilepsi a nam gwybyddol cyd-forbid.
- Cannabinoidau fel targed therapiwtig posibl ar gyfer Epilepsi Absenoldeb.
- Gwahaniaethau rhwng y rhywiau mewn effeithiau niweidiol hirdymor goryfed a cham-drin canabis.
Cyhoeddiad
2024
- Casarrubea, M. et al. 2024. Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board. Progress in Neuro-Psychopharmacology and Biological Psychiatry 133, article number: 111034. (10.1016/j.pnpbp.2024.111034)
- Casarrubea, M. et al. 2024. A quantitative and T‐pattern analysis of anxiety‐like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests. CNS Neuroscience and Therapeutics 30(3), article number: e14443. (10.1111/cns.14443)
2023
- Casarrubea, M., Di Giovanni, G., Aiello, S. and Crescimanno, G. 2023. The Hole-Board apparatus in the study of anxiety. Physiology & Behavior 271, article number: 114346. (10.1016/j.physbeh.2023.114346)
- Neuparth-Sottomayor, M. et al. 2023. Cognitive comorbidities of experimental absence seizures are independent of anxiety. Neurobiology of Disease 186, article number: 106275. (10.1016/j.nbd.2023.106275)
- Arias, H. R., De Deurwaerdère, P., Scholze, P., Sakamoto, S., Hamachi, I., Di Giovanni, G. and Chagraoui, A. 2023. Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA. European Journal of Pharmacology 953, article number: 175854. (10.1016/j.ejphar.2023.175854)
- Peters, J., Trabace, L. and Di Giovanni, G. 2023. Editorial: The role of alcohol in modifying behavior. Frontiers in Behavioral Neuroscience 17, article number: 1175405. (10.3389/fnbeh.2023.1175405)
- Abela, N., Haywood, K. and Di Giovanni, G. 2023. Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment. Frontiers in Behavioral Neuroscience 17, article number: 1129866. (10.3389/fnbeh.2023.1129866)
- Arias, H. R. et al. 2023. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. European Journal of Pharmacology 939, article number: 175454. (10.1016/j.ejphar.2022.175454)
2022
- De Deurwaerdère, P., Ponimaskin, E., Chagraoui, A. and Di Giovanni, G. 2022. Editorial: new GPCR targets and modulators to treat CNS disorders. Frontiers in Molecular Neuroscience 15, article number: 1104336. (10.3389/fnmol.2022.1104336)
- De Deurwaerdere, P., Samb, N., El Boukhari, H., Corne, R., Chagraoui, A. and Di Giovanni, G. 2022. In vivo study of monoamine oxidases using multisite intracerebral microdialysis. In: Methods in Molecular Biology: Monoamine Oxidase., Vol. 2558. Methods in Molecular Biology Humana, New York: Springer, pp. 183-195., (10.1007/978-1-0716-2643-6_14)
- Cassar, D., Radic, M., Casarrubea, M., Crunelli, V. and Di Giovanni, G. 2022. The effect of cannabinoid receptor agonist WIN 55,212–2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze. CNS Neuroscience and Therapeutics 28(8), pp. 1268-1270. (10.1111/cns.13848)
- De Deurwaerdère, P. and Di Giovanni, G. 2022. Pathophysiology of the serotonin system in the nervous system and beyond. International Journal of Molecular Sciences 23(9), article number: 4712. (10.3390/ijms23094712)
- Chagraoui, A., Di Giovanni, G. and De Deurwaerdère, P. 2022. Neurobiological and pharmacological perspectives of D3 receptors in Parkinson's disease. Biomolecules 12(2), article number: 243. (10.3390/biom12020243)
- Pierucci, M. et al. 2022. Nicotine modulation of the lateral habenula/ventral tegmental area circuit dynamics: An electrophysiological study in rats. Neuropharmacology 202, article number: 108859. (10.1016/j.neuropharm.2021.108859)
2021
- Deidda, G., Pierucci, M., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in neurodevelopment and plasticity. In: Progress in Brain Research., Vol. 259. ELSEVIER SCIENCE BV, pp. 287-317., (10.1016/bs.pbr.2021.01.009)
- Gazea, M. et al. 2021. Reciprocal lateral hypothalamic and raphe GABAergic projections promote wakefulness. Journal of Neuroscience 41(22), pp. 4840-4849. (10.1523/JNEUROSCI.2850-20.2021)
- Casarrubea, M., Di Giovanni, G. and Crescimanno, G. 2021. Effects of different anxiety levels on the behavioral patternings investigated through T-pattern analysis in Wistar rats tested in the Hole-Board apparatus. Brain Sciences 11(6), article number: 714. (10.3390/brainsci11060714)
- Grillo, A. et al. 2021. Selective fatty acid amide hydrolase inhibitors as potential novel antiepileptic agents. ACS Chemical Neuroscience 12(9), pp. 1716. (10.1021/acschemneuro.1c00192)
- Bombardi, C. et al. 2021. Lateral habenula 5-HT2C receptor function Is altered by acute and chronic nicotine exposures. International Journal of Molecular Sciences 22(9), article number: 4775. (10.3390/ijms22094775)
- De Deurwaerdère, P., Chagraoui, A. and Di Giovanni, G. 2021. Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B., Vol. 261. Progress in Brain Research Elsevier, pp. 161-264., (10.1016/bs.pbr.2021.02.001)
- Beyeler, A., Ju, A., Chagraoui, A., Cuvelle, L., Teixeira, M., Di Giovanni, G. and De Deurwaerdère, P. 2021. Multiple facets of serotonergic modulation. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B., Vol. 261. Progress in Brain Research Elsevier, pp. 3-39., (10.1016/bs.pbr.2021.02.002)
- Bombardi, C. et al. 2021. Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B., Vol. 261. Progress in Brain Research Elsevier, pp. 83-158., (10.1016/bs.pbr.2021.01.031)
- Casarrubea, M. et al. 2021. The impact of chronic daily nicotine exposure and its overnight withdrawal on the structure of anxiety-related behaviors in rats: Role of the lateral habenula. Progress in Neuro-Psychopharmacology and Biological Psychiatry 105, article number: 110131. (10.1016/j.pnpbp.2020.110131)
- Deidda, G., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in epilepsy. In: Progress in Brain Research., Vol. 259. ELSEVIER, pp. 265-286., (10.1016/bs.pbr.2021.01.008)
- De Deurwaerdere, P. and Di Giovanni, G. 2021. 5-HT interaction with other neurotransmitters: an overview. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part A., Vol. 259. Progress in Brain Research Elsevier, pp. 1-5., (10.1016/bs.pbr.2021.01.001)
- Colangeli, R., Teskey, G. C. and Di Giovanni, G. 2021. Endocannabinoid-serotonin systems interaction in health and disease. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part A., Vol. 259. Progress in Brain Research Elsevier, pp. 83-134., (10.1016/bs.pbr.2021.01.003)
2020
- Crunelli, V., Lorincz, M. L., McCafferty, C., Regis, L. C., Leresche, N., Di Giovanni, G. and David, F. 2020. Clinical and experimental insight in pathophysiology, comorbidity and therapy of absence seizures. Brain 143(8), pp. 2341-2368. (10.1093/brain/awaa072)
2018
- David, F. et al. 2018. Suppression of HCN channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. Journal of Neuroscience 38(30), pp. 6615-6627. (10.1523/JNEUROSCI.0896-17.2018)
- Di Giovanni, G., Crunelli, V. and Rizzolatti, G. 2018. Editorial: Interdisciplinary approaches for neuropathology. CNS Neuroscience & Therapeutics 24(8), pp. 665-668. (10.1111/cns.13004)
- Bombardi, C., Venzi, M., Crunelli, V. and Di Giovanni, G. 2018. Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. Neuropharmacology 136(Part A), pp. 56-67. (10.1016/j.neuropharm.2018.01.047)
- McCafferty, C. et al. 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience 21, pp. 744-756. (10.1038/s41593-018-0130-4)
- Colangeli, R., Pierucci, M., Benigno, A., Campiani, G., Butini, S. and Di Giovanni, G. 2018. The FAAH inhibitor URB597 suppresses hippocampal maximal dentate after-discharges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific Reports 7, article number: 11152. (10.1038/s41598-017-11606-1)
2017
- Bortolato, M. and Di Giovanni, G. 2017. Editorial on Special Issue: Animal models of Tourette syndrome. Journal of Neuroscience Methods 292, pp. 1. (10.1016/j.jneumeth.2017.10.008)
- De Deurwaerdere, P., Ramsay, R. R. and Di Giovanni, G. 2017. Neurobiology and neuropharmacology of monoaminergic systems. Progress in Neurobiology 151, pp. 1-3. (10.1016/j.pneurobio.2017.02.001)
- De Deurwaerdere, P., Di Giovanni, G. and Millan, M. J. 2017. Expanding the repertoire of L-DOPA's actions: A comprehensive review of its functional neurochemistry. Progress in Neurobiology 151, pp. 57-100. (10.1016/j.pneurobio.2016.07.002)
- Schiavone, S. et al. 2017. Early loss of blood-brain barrier integrity precedes NOX2 elevation in the prefrontal cortex of an animal model of psychosis. Molecular Neurobiology 54(3), pp. 2031-2044. (10.1007/s12035-016-9791-8)
- Simic, G. et al. 2017. Monoaminergic neuropathology in Alzheimer's disease. Progress in Neurobiology 151, pp. 101-138. (10.1016/j.pneurobio.2016.04.001)
2016
- Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V. and Di Giovanni, G. 2016. Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology 108, pp. 292-304. (10.1016/j.neuropharm.2016.04.016)
2015
- Crunelli, V. and Di Giovanni, G. 2015. Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [Letter]. CNS Neuroscience & Therapeutics 21(12), pp. 967-970. (10.1111/cns.12480)
- Venzi, M., Di Giovanni, G. and Crunelli, V. 2015. A critical evaluation of the Gamma-Hydroxybutyrate (GHB) model of absence seizures. CNS Neuroscience & Therapeutics 21(2), pp. 123-140. (10.1111/cns.12337)
2014
- Godar, S. C., Mosher, L. J., Di Giovanni, G. and Bortolato, M. 2014. Animal models of tic disorders: a translational perspective. Journal of Neuroscience Methods 238, pp. 54-69. (10.1016/j.jneumeth.2014.09.008)
- Taylor, H. L. et al. 2014. Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo. Journal of Neuroscience Methods 235, pp. 83-91. (10.1016/j.jneumeth.2014.06.031)
- Crunelli, V. and Di Giovanni, G. 2014. Monoamine modulation of tonic GABAA inhibition. Reviews in the Neurosciences 25(2), pp. 195-206. (10.1515/revneuro-2013-0059)
2013
- David, F. et al. 2013. Essential thalamic contribution to slow waves of natural sleep. Journal of Neuroscience 33(50), article number: 19599. (10.1523/JNEUROSCI.3169-13.2013)
- Yagüe, J. G., Cavaccini, A., Errington, A. C., Crunelli, V. and Di Giovanni, G. 2013. Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats. Experimental Neurology 247, pp. 1-7. (10.1016/j.expneurol.2013.03.023)
2011
- Errington, A. C., Di Giovanni, G., Crunelli, V. and Cope, D. W. 2011. mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus. Journal of Neuroscience 31(23), pp. 8669-8680. (10.1523/JNEUROSCI.0317-11.2011)
2009
- Cope, D. W. et al. 2009. Enhanced tonic GABA(A) inhibition in typical absence epilepsy. Nature Medicine 15(12), pp. 1392-1398. (10.1038/nm.2058)
Adrannau llyfrau
- De Deurwaerdere, P., Samb, N., El Boukhari, H., Corne, R., Chagraoui, A. and Di Giovanni, G. 2022. In vivo study of monoamine oxidases using multisite intracerebral microdialysis. In: Methods in Molecular Biology: Monoamine Oxidase., Vol. 2558. Methods in Molecular Biology Humana, New York: Springer, pp. 183-195., (10.1007/978-1-0716-2643-6_14)
- Deidda, G., Pierucci, M., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in neurodevelopment and plasticity. In: Progress in Brain Research., Vol. 259. ELSEVIER SCIENCE BV, pp. 287-317., (10.1016/bs.pbr.2021.01.009)
- De Deurwaerdère, P., Chagraoui, A. and Di Giovanni, G. 2021. Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B., Vol. 261. Progress in Brain Research Elsevier, pp. 161-264., (10.1016/bs.pbr.2021.02.001)
- Beyeler, A., Ju, A., Chagraoui, A., Cuvelle, L., Teixeira, M., Di Giovanni, G. and De Deurwaerdère, P. 2021. Multiple facets of serotonergic modulation. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B., Vol. 261. Progress in Brain Research Elsevier, pp. 3-39., (10.1016/bs.pbr.2021.02.002)
- Bombardi, C. et al. 2021. Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part B., Vol. 261. Progress in Brain Research Elsevier, pp. 83-158., (10.1016/bs.pbr.2021.01.031)
- Deidda, G., Crunelli, V. and Di Giovanni, G. 2021. 5-HT/GABA interaction in epilepsy. In: Progress in Brain Research., Vol. 259. ELSEVIER, pp. 265-286., (10.1016/bs.pbr.2021.01.008)
- De Deurwaerdere, P. and Di Giovanni, G. 2021. 5-HT interaction with other neurotransmitters: an overview. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part A., Vol. 259. Progress in Brain Research Elsevier, pp. 1-5., (10.1016/bs.pbr.2021.01.001)
- Colangeli, R., Teskey, G. C. and Di Giovanni, G. 2021. Endocannabinoid-serotonin systems interaction in health and disease. In: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance - Part A., Vol. 259. Progress in Brain Research Elsevier, pp. 83-134., (10.1016/bs.pbr.2021.01.003)
Erthyglau
- Casarrubea, M. et al. 2024. Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board. Progress in Neuro-Psychopharmacology and Biological Psychiatry 133, article number: 111034. (10.1016/j.pnpbp.2024.111034)
- Casarrubea, M. et al. 2024. A quantitative and T‐pattern analysis of anxiety‐like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests. CNS Neuroscience and Therapeutics 30(3), article number: e14443. (10.1111/cns.14443)
- Casarrubea, M., Di Giovanni, G., Aiello, S. and Crescimanno, G. 2023. The Hole-Board apparatus in the study of anxiety. Physiology & Behavior 271, article number: 114346. (10.1016/j.physbeh.2023.114346)
- Neuparth-Sottomayor, M. et al. 2023. Cognitive comorbidities of experimental absence seizures are independent of anxiety. Neurobiology of Disease 186, article number: 106275. (10.1016/j.nbd.2023.106275)
- Arias, H. R., De Deurwaerdère, P., Scholze, P., Sakamoto, S., Hamachi, I., Di Giovanni, G. and Chagraoui, A. 2023. Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA. European Journal of Pharmacology 953, article number: 175854. (10.1016/j.ejphar.2023.175854)
- Peters, J., Trabace, L. and Di Giovanni, G. 2023. Editorial: The role of alcohol in modifying behavior. Frontiers in Behavioral Neuroscience 17, article number: 1175405. (10.3389/fnbeh.2023.1175405)
- Abela, N., Haywood, K. and Di Giovanni, G. 2023. Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment. Frontiers in Behavioral Neuroscience 17, article number: 1129866. (10.3389/fnbeh.2023.1129866)
- Arias, H. R. et al. 2023. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. European Journal of Pharmacology 939, article number: 175454. (10.1016/j.ejphar.2022.175454)
- De Deurwaerdère, P., Ponimaskin, E., Chagraoui, A. and Di Giovanni, G. 2022. Editorial: new GPCR targets and modulators to treat CNS disorders. Frontiers in Molecular Neuroscience 15, article number: 1104336. (10.3389/fnmol.2022.1104336)
- Cassar, D., Radic, M., Casarrubea, M., Crunelli, V. and Di Giovanni, G. 2022. The effect of cannabinoid receptor agonist WIN 55,212–2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze. CNS Neuroscience and Therapeutics 28(8), pp. 1268-1270. (10.1111/cns.13848)
- De Deurwaerdère, P. and Di Giovanni, G. 2022. Pathophysiology of the serotonin system in the nervous system and beyond. International Journal of Molecular Sciences 23(9), article number: 4712. (10.3390/ijms23094712)
- Chagraoui, A., Di Giovanni, G. and De Deurwaerdère, P. 2022. Neurobiological and pharmacological perspectives of D3 receptors in Parkinson's disease. Biomolecules 12(2), article number: 243. (10.3390/biom12020243)
- Pierucci, M. et al. 2022. Nicotine modulation of the lateral habenula/ventral tegmental area circuit dynamics: An electrophysiological study in rats. Neuropharmacology 202, article number: 108859. (10.1016/j.neuropharm.2021.108859)
- Gazea, M. et al. 2021. Reciprocal lateral hypothalamic and raphe GABAergic projections promote wakefulness. Journal of Neuroscience 41(22), pp. 4840-4849. (10.1523/JNEUROSCI.2850-20.2021)
- Casarrubea, M., Di Giovanni, G. and Crescimanno, G. 2021. Effects of different anxiety levels on the behavioral patternings investigated through T-pattern analysis in Wistar rats tested in the Hole-Board apparatus. Brain Sciences 11(6), article number: 714. (10.3390/brainsci11060714)
- Grillo, A. et al. 2021. Selective fatty acid amide hydrolase inhibitors as potential novel antiepileptic agents. ACS Chemical Neuroscience 12(9), pp. 1716. (10.1021/acschemneuro.1c00192)
- Bombardi, C. et al. 2021. Lateral habenula 5-HT2C receptor function Is altered by acute and chronic nicotine exposures. International Journal of Molecular Sciences 22(9), article number: 4775. (10.3390/ijms22094775)
- Casarrubea, M. et al. 2021. The impact of chronic daily nicotine exposure and its overnight withdrawal on the structure of anxiety-related behaviors in rats: Role of the lateral habenula. Progress in Neuro-Psychopharmacology and Biological Psychiatry 105, article number: 110131. (10.1016/j.pnpbp.2020.110131)
- Crunelli, V., Lorincz, M. L., McCafferty, C., Regis, L. C., Leresche, N., Di Giovanni, G. and David, F. 2020. Clinical and experimental insight in pathophysiology, comorbidity and therapy of absence seizures. Brain 143(8), pp. 2341-2368. (10.1093/brain/awaa072)
- David, F. et al. 2018. Suppression of HCN channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. Journal of Neuroscience 38(30), pp. 6615-6627. (10.1523/JNEUROSCI.0896-17.2018)
- Di Giovanni, G., Crunelli, V. and Rizzolatti, G. 2018. Editorial: Interdisciplinary approaches for neuropathology. CNS Neuroscience & Therapeutics 24(8), pp. 665-668. (10.1111/cns.13004)
- Bombardi, C., Venzi, M., Crunelli, V. and Di Giovanni, G. 2018. Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. Neuropharmacology 136(Part A), pp. 56-67. (10.1016/j.neuropharm.2018.01.047)
- McCafferty, C. et al. 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience 21, pp. 744-756. (10.1038/s41593-018-0130-4)
- Colangeli, R., Pierucci, M., Benigno, A., Campiani, G., Butini, S. and Di Giovanni, G. 2018. The FAAH inhibitor URB597 suppresses hippocampal maximal dentate after-discharges and restores seizure-induced impairment of short and long-term synaptic plasticity. Scientific Reports 7, article number: 11152. (10.1038/s41598-017-11606-1)
- Bortolato, M. and Di Giovanni, G. 2017. Editorial on Special Issue: Animal models of Tourette syndrome. Journal of Neuroscience Methods 292, pp. 1. (10.1016/j.jneumeth.2017.10.008)
- De Deurwaerdere, P., Ramsay, R. R. and Di Giovanni, G. 2017. Neurobiology and neuropharmacology of monoaminergic systems. Progress in Neurobiology 151, pp. 1-3. (10.1016/j.pneurobio.2017.02.001)
- De Deurwaerdere, P., Di Giovanni, G. and Millan, M. J. 2017. Expanding the repertoire of L-DOPA's actions: A comprehensive review of its functional neurochemistry. Progress in Neurobiology 151, pp. 57-100. (10.1016/j.pneurobio.2016.07.002)
- Schiavone, S. et al. 2017. Early loss of blood-brain barrier integrity precedes NOX2 elevation in the prefrontal cortex of an animal model of psychosis. Molecular Neurobiology 54(3), pp. 2031-2044. (10.1007/s12035-016-9791-8)
- Simic, G. et al. 2017. Monoaminergic neuropathology in Alzheimer's disease. Progress in Neurobiology 151, pp. 101-138. (10.1016/j.pneurobio.2016.04.001)
- Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V. and Di Giovanni, G. 2016. Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology 108, pp. 292-304. (10.1016/j.neuropharm.2016.04.016)
- Crunelli, V. and Di Giovanni, G. 2015. Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [Letter]. CNS Neuroscience & Therapeutics 21(12), pp. 967-970. (10.1111/cns.12480)
- Venzi, M., Di Giovanni, G. and Crunelli, V. 2015. A critical evaluation of the Gamma-Hydroxybutyrate (GHB) model of absence seizures. CNS Neuroscience & Therapeutics 21(2), pp. 123-140. (10.1111/cns.12337)
- Godar, S. C., Mosher, L. J., Di Giovanni, G. and Bortolato, M. 2014. Animal models of tic disorders: a translational perspective. Journal of Neuroscience Methods 238, pp. 54-69. (10.1016/j.jneumeth.2014.09.008)
- Taylor, H. L. et al. 2014. Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo. Journal of Neuroscience Methods 235, pp. 83-91. (10.1016/j.jneumeth.2014.06.031)
- Crunelli, V. and Di Giovanni, G. 2014. Monoamine modulation of tonic GABAA inhibition. Reviews in the Neurosciences 25(2), pp. 195-206. (10.1515/revneuro-2013-0059)
- David, F. et al. 2013. Essential thalamic contribution to slow waves of natural sleep. Journal of Neuroscience 33(50), article number: 19599. (10.1523/JNEUROSCI.3169-13.2013)
- Yagüe, J. G., Cavaccini, A., Errington, A. C., Crunelli, V. and Di Giovanni, G. 2013. Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats. Experimental Neurology 247, pp. 1-7. (10.1016/j.expneurol.2013.03.023)
- Errington, A. C., Di Giovanni, G., Crunelli, V. and Cope, D. W. 2011. mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus. Journal of Neuroscience 31(23), pp. 8669-8680. (10.1523/JNEUROSCI.0317-11.2011)
- Cope, D. W. et al. 2009. Enhanced tonic GABA(A) inhibition in typical absence epilepsy. Nature Medicine 15(12), pp. 1392-1398. (10.1038/nm.2058)
- Bombardi, C., Venzi, M., Crunelli, V. and Di Giovanni, G. 2018. Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. Neuropharmacology 136(Part A), pp. 56-67. (10.1016/j.neuropharm.2018.01.047)
- McCafferty, C. et al. 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience 21, pp. 744-756. (10.1038/s41593-018-0130-4)
- Venzi, M., David, F., Bellet, J., Cavaccini, A., Bombardi, C., Crunelli, V. and Di Giovanni, G. 2016. Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures. Neuropharmacology 108, pp. 292-304. (10.1016/j.neuropharm.2016.04.016)
- Crunelli, V. and Di Giovanni, G. 2015. Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [Letter]. CNS Neuroscience & Therapeutics 21(12), pp. 967-970. (10.1111/cns.12480)
- Venzi, M., Di Giovanni, G. and Crunelli, V. 2015. A critical evaluation of the Gamma-Hydroxybutyrate (GHB) model of absence seizures. CNS Neuroscience & Therapeutics 21(2), pp. 123-140. (10.1111/cns.12337)
- Godar, S. C., Mosher, L. J., Di Giovanni, G. and Bortolato, M. 2014. Animal models of tic disorders: a translational perspective. Journal of Neuroscience Methods 238, pp. 54-69. (10.1016/j.jneumeth.2014.09.008)
- Taylor, H. L. et al. 2014. Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo. Journal of Neuroscience Methods 235, pp. 83-91. (10.1016/j.jneumeth.2014.06.031)
- Crunelli, V. and Di Giovanni, G. 2014. Monoamine modulation of tonic GABAA inhibition. Reviews in the Neurosciences 25(2), pp. 195-206. (10.1515/revneuro-2013-0059)
- David, F. et al. 2013. Essential thalamic contribution to slow waves of natural sleep. Journal of Neuroscience 33(50), article number: 19599. (10.1523/JNEUROSCI.3169-13.2013)
- Yagüe, J. G., Cavaccini, A., Errington, A. C., Crunelli, V. and Di Giovanni, G. 2013. Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats. Experimental Neurology 247, pp. 1-7. (10.1016/j.expneurol.2013.03.023)
- Errington, A. C., Di Giovanni, G., Crunelli, V. and Cope, D. W. 2011. mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus. Journal of Neuroscience 31(23), pp. 8669-8680. (10.1523/JNEUROSCI.0317-11.2011)
- Cope, D. W. et al. 2009. Enhanced tonic GABA(A) inhibition in typical absence epilepsy. Nature Medicine 15(12), pp. 1392-1398. (10.1038/nm.2058)
Ymchwil
Grŵp Ymchwil Lab Niwroffisioleg
Aelodau'r Grŵp:
1. Dr Massimo Pierucci, Ôl-doc (Prifysgol Malta) (2010-) Teitl y prosiect: Rôl yr habenula ochrol mewn caethiwed ac iselder nicotin. Astudiaeth electroffisiolegol, niwrocemegol ac anatomegol mewn llygod mawr.
2. Dr Daniel Cassar, myfyriwr PhD (Prifysgol Malta) (2017-) Teitl y prosiect: Rôl system serotoninergic mewn epilepsi a nam gwybyddol cyd-forbid. Astudiaeth electroffisiolegol, niwrocemegol ac anatomegol mewn llygod mawr.
3. Dr Chris Cremona, myfyriwr PhD (Prifysgol Malta) (2016-) Teitl y prosiect: Datgelu rôl cannabinoidau fel Targed Therapiwtig Posibl ar gyfer Epilepsi Absenoldeb.
4. Mr Norbert Abela, myfyriwr MS (Prifysgol Malta) (2016-). Teitl y prosiect: Gwahaniaethau Rhyw mewn Effeithiau Niweidiol hirdymor Yfed Binge a Cham-drin Canabis: Astudiaeth Electroffisiolegol, Ymddygiadol a Niwroanatomegol mewn llygod mawr.
5. Ms Stephanie Mari Camilleri (Prifysgol Malta) (2016-) Teitl y prosiect: Effeithiau epigenetig goryfed plant (F0) ar epigenetig gor-yfed ar epil oedolion (F1) pryder a nodweddion iselder. Myfyriwr Seicoleg.
Grantiau Rhyngwladol:
R&I-2013-014, o'r enw 'Closed loop Serotonin optogenetic Stimulate with EEG recording to Suppress Epileptic Seizures: A Therapeutic Device' € 150000 PI, GDG (AAT MT a phartneriaid allanol Cardiff UK). 3 blynedd (11/2014- 10/2017).
Epilepsy Research UK grant N. P1202 o'r enw 'Modiwleiddio serotonergig o GABA tonig Aatal : goblygiadau pathoffisiolegol a therapiwtig ar gyfer trawiadau absennol'. 3 blynedd, £50,000.
Cymdeithas Ffisiolegol y Deyrnas Unedig. Grant Ymchwil Uwch Ryngwladol. Recordiadau ensemble Niwronol Dopamanine mewn llygod mawr sy'n symud yn rhydd. £7000.
PON (programmi operativi nazionali), Yr Eidal. "Polo Cyberbrain". Consortiwm (NEUROMED, IEMEST, Fondazione Nerone di Roma) € 5,000,000.
Partneriaethau:
Yr Athro Vincenzo Crunelli, Prifysgol Caerdydd.
Yr Athro Philippe de Deurwaerdere, Université de Bordeaux, Ffrainc.
Yr Athro Mauro Pessia, Prifysgol Malta, Malta.
Yr Athro Giacomo Rizzolatti, Prifysgol Parma, yr Eidal.
Bywgraffiad
Derbyniodd Giuseppe Di Giovanni ei Ph.D. mewn Niwrowyddoniaeth o Brifysgol Chieti, yr Eidal, ac roedd yn gymrawd ôl-ddoethurol ym Mhrifysgol Yale, UDA. Cyn hynny, bu'n Uwch Ddarlithydd Ffisioleg Ddynol yn y Gyfadran Meddygaeth a Llawfeddygaeth, Prifysgol Palermo, ac yn ddiweddarach, yn Athro Cyswllt ac yna'n Athro ym Mhrifysgol Malta. Ar hyn o bryd, mae'n Athro Ffisioleg Dynol yn Ysgol Feddygol Prifysgol "Magna Graecia" Catanzaro, yr Eidal.
Mae ei ymchwil yn canolbwyntio ar ddeall pathoffisioleg systemau monoaminergig gan ddefnyddio dulliau electroffisiolegol a niwrocemegol. Mae wedi cyhoeddi dros 200 o bapurau a adolygwyd gan gymheiriaid, wedi golygu 7 llyfr, ac 8 rhifyn arbennig o gyfnodolion amrywiol. Ef yw Ysgrifennydd Cyffredinol presennol IBRO ac Is-lywydd Cymdeithas Niwrowyddoniaeth Môr y Canoldir (MPS). Ef yw Prif Olygydd y cyfnodolyn nodedig Journal of Neuroscience Methods gan Elsevier, Amsterdam, yr Iseldiroedd, a Golygydd y gyfres lyfrau "The Receptors" gan Springer, UDA (http://www.springer.com/series/7668). Yn ogystal, mae'n gwasanaethu fel golygydd cyswllt ar gyfer CNS Neuroscience and Therapeutics gan Wiley.
Anrhydeddau a dyfarniadau
Ar 28 Mai 2020 dyfarnwyd anrhydedd Cavaliere (Knight) Urdd Seren yr Eidal iddo gan Arlywydd Gweriniaeth yr Eidal Sergio Mattarella.