Dr Selinda Orr
Timau a rolau for Selinda Orr
Cyhoeddiad
2021
- Griffiths, J. S. et al. 2021. A novel strategy to identify haematology patients at high risk of developing Aspergillosis. Frontiers in Immunology 12, article number: 780160. (10.3389/fimmu.2021.780160)
- Griffiths, J. S. et al. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224(7), pp. 1219-1224. (10.1093/infdis/jiab145)
- Thompson, A., da Fonseca, D. M., Walker, L., Griffiths, J. S., Taylor, P. R., Gow, N. A. R. and Orr, S. J. 2021. Dependence on Mincle and Dectin-2 varies with multiple Candida species during systemic infection. Frontiers in Microbiology 12, article number: 633229. (10.3389/fmicb.2021.633229)
2020
2019
- Thompson, A. et al. 2019. Dependence on Dectin-1 varies with multiple candida species. Frontiers in Microbiology 10, article number: 1800. (10.3389/fmicb.2019.01800)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Patin, E. C., Thompson, A. and Orr, S. J. 2019. Pattern recognition receptors in fungal immunity. Seminars in Cell & Developmental Biology 89, pp. 24-33. (10.1016/j.semcdb.2018.03.003)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
2018
2017
2016
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197(1), pp. 208-221. (10.4049/jimmunol.1501204)
- Burg, A., Quigley, L., Jones, A. V., O'Connor, G., Boelte, K., McVicar, D. and Orr, S. J. 2016. Orally administered β-glucan attenuates
the Th2 response in a model of airway
hypersensitivity. SpringerPlus 5, article number: 815. (10.1186/s40064-016-2501-1)
- Patin, E. C., Willcocks, S., Orr, S. J., Ward, T. H., Lang, R. and Schaible, U. E. 2016. Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immunity 22(3), pp. 181-185. (10.1177/1753425916636671)
2015
- Bryant, C. E., Orr, S. J., Ferguson, B., Symmons, M. F., Boyle, J. P. and Monie, T. P. 2015. International union of basic and clinical pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacological Reviews 67(2), pp. 462-504. (10.1124/pr.114.009928)
2014
2013
2012
2010
- Orr, S. J., Roessler, S., Quigley, L., Chan, T., Ford, J. W., O'Connor, G. M. and McVicar, D. W. 2010. Implications for gene therapy-limiting expression of IL-2R c delineate differences in signaling thresholds required for lymphocyte development and maintenance. The Journal of Immunology 185(3), pp. 1393-1403. (10.4049/jimmunol.0903528)
- Orr, S. J. and McVicar, D. W. 2010. LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?. Journal of Leukocyte Biology 89(1), pp. 11-19. (10.1189/jlb.0410221)
- Whittaker, G. C., Orr, S. J., Quigley, L., Hughes, L., Francischetti, I. M. B., Zhang, W. and McVicar, D. W. 2010. The linker for activation of B cells (LAB)/Non-T Cell Activation Linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage Inflammatory responses independently of the linker for activation of T cells. Journal of Biological Chemistry 285(5), pp. 2976-2985. (10.1074/jbc.M109.038398)
2009
2008
- Whittaker, G. C. et al. 2008. Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. Blood 112(7), pp. 2869-2877. (10.1182/blood-2007-11-121590)
- Scott, C. J., Marouf, W. M., Quinn, D. J., Buick, R. J., Orr, S. J., Donnelly, R. F. and McCarron, P. A. 2008. Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles. Pharmaceutical Research 25(1), pp. 135-146. (10.1007/s11095-007-9400-7)
2007
- Orr, S. J., Morgan, N. M., Elliott, J., Burrows, J. F., Scott, C. J., McVicar, D. W. and Johnston, J. A. 2007. CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover. Blood 109(3), pp. 1061-1068. (10.1182/blood-2006-05-023556)
2006
Erthyglau
- Griffiths, J. S. et al. 2021. A novel strategy to identify haematology patients at high risk of developing Aspergillosis. Frontiers in Immunology 12, article number: 780160. (10.3389/fimmu.2021.780160)
- Griffiths, J. S. et al. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224(7), pp. 1219-1224. (10.1093/infdis/jiab145)
- Thompson, A., da Fonseca, D. M., Walker, L., Griffiths, J. S., Taylor, P. R., Gow, N. A. R. and Orr, S. J. 2021. Dependence on Mincle and Dectin-2 varies with multiple Candida species during systemic infection. Frontiers in Microbiology 12, article number: 633229. (10.3389/fmicb.2021.633229)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Thompson, A. et al. 2019. Dependence on Dectin-1 varies with multiple candida species. Frontiers in Microbiology 10, article number: 1800. (10.3389/fmicb.2019.01800)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Patin, E. C., Thompson, A. and Orr, S. J. 2019. Pattern recognition receptors in fungal immunity. Seminars in Cell & Developmental Biology 89, pp. 24-33. (10.1016/j.semcdb.2018.03.003)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
- Thompson, A. and Orr, S. J. 2018. Emerging IL-12 family cytokines in the fight against fungal infections. Cytokine(111), pp. 398-407. (10.1016/j.cyto.2018.05.019)
- Patin, E. C., Orr, S. J. and Schaible, U. E. 2017. Macrophage inducible C-type lectin as a multifunctional player in immunity. Frontiers in Immunology 8, article number: 861. (10.3389/fimmu.2017.00861)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197(1), pp. 208-221. (10.4049/jimmunol.1501204)
- Burg, A., Quigley, L., Jones, A. V., O'Connor, G., Boelte, K., McVicar, D. and Orr, S. J. 2016. Orally administered β-glucan attenuates
the Th2 response in a model of airway
hypersensitivity. SpringerPlus 5, article number: 815. (10.1186/s40064-016-2501-1)
- Patin, E. C., Willcocks, S., Orr, S. J., Ward, T. H., Lang, R. and Schaible, U. E. 2016. Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate Immunity 22(3), pp. 181-185. (10.1177/1753425916636671)
- Bryant, C. E., Orr, S. J., Ferguson, B., Symmons, M. F., Boyle, J. P. and Monie, T. P. 2015. International union of basic and clinical pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacological Reviews 67(2), pp. 462-504. (10.1124/pr.114.009928)
- Cardone, M. et al. 2014. Interleukin-1 and interferon-γ orchestrate β-glucan-activated human dendritic cell programming via IκB-ζ modulation. PLoS ONE 9(12), article number: e114516. (10.1371/journal.pone.0114516)
- Orr, S. J. et al. 2013. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells. PLoS Pathogens 9(5), article number: e1003357. (10.1371/journal.ppat.1003357)
- Karsten, C. M. et al. 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1 [Letter]. Nature Medicine 18(9), pp. 1401-1406. (10.1038/nm.2862)
- Orr, S. J., Roessler, S., Quigley, L., Chan, T., Ford, J. W., O'Connor, G. M. and McVicar, D. W. 2010. Implications for gene therapy-limiting expression of IL-2R c delineate differences in signaling thresholds required for lymphocyte development and maintenance. The Journal of Immunology 185(3), pp. 1393-1403. (10.4049/jimmunol.0903528)
- Orr, S. J. and McVicar, D. W. 2010. LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?. Journal of Leukocyte Biology 89(1), pp. 11-19. (10.1189/jlb.0410221)
- Whittaker, G. C., Orr, S. J., Quigley, L., Hughes, L., Francischetti, I. M. B., Zhang, W. and McVicar, D. W. 2010. The linker for activation of B cells (LAB)/Non-T Cell Activation Linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage Inflammatory responses independently of the linker for activation of T cells. Journal of Biological Chemistry 285(5), pp. 2976-2985. (10.1074/jbc.M109.038398)
- Orr, S. J., Quigley, L. and McVicar, D. W. 2009. In vivo expression of signaling proteins in reconstituted NK cells. Journal of Immunological Methods 340(2), pp. 158-163. (10.1016/j.jim.2008.10.014)
- Boyd, C. R. et al. 2009. Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production. The Journal of Immunology 183(12), pp. 7703-7709. (10.4049/jimmunol.0902780)
- Whittaker, G. C. et al. 2008. Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. Blood 112(7), pp. 2869-2877. (10.1182/blood-2007-11-121590)
- Scott, C. J., Marouf, W. M., Quinn, D. J., Buick, R. J., Orr, S. J., Donnelly, R. F. and McCarron, P. A. 2008. Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles. Pharmaceutical Research 25(1), pp. 135-146. (10.1007/s11095-007-9400-7)
- Orr, S. J., Morgan, N. M., Elliott, J., Burrows, J. F., Scott, C. J., McVicar, D. W. and Johnston, J. A. 2007. CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover. Blood 109(3), pp. 1061-1068. (10.1182/blood-2006-05-023556)
- Orr, S. J. et al. 2006. SOCS3 targets siglec 7 for proteasomal degradation and blocks siglec 7-mediated responses. Journal of Biological Chemistry 282(6), pp. 3418-3422. (10.1074/jbc.C600216200)