Dr Girish Kandubhai Patel
Senior Lecturer
Ysgol y Biowyddorau
Trosolwyg
Research overview
My group researches cancer stem cells in the common human skin cancers: basal cell carcinoma, squamous cell carcinoma and melanoma. The primary aims of the group are to elucidate the evolution and progression of cancer stem cells in primary and metastatic disease, and in so doing identify and validate novel cancer biomarkers and therapeutic targets.
Research division
Related link
Cyhoeddiad
2024
- Lovatt, C. et al. 2024. Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules. Skin Health and Disease 4(5), article number: e394. (10.1002/ski2.394)
- Morgan, H. J. et al. 2024. HPV8-induced STAT3 activation led keratinocyte stem cell expansion in human actinic keratoses. JCI Insight 9(15), article number: e177898. (10.1172/jci.insight.177898)
2022
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
2020
- Morgan, H. J. et al. 2020. Human basal cell carcinoma: the induction of anagen hair follicle differentiation. Clinical and Experimental Dermatology 45(3), pp. 309-317. (10.1111/ced.14108)
- Adams-Smith, R., Colmont, C., Mukhtar, A., Morgan, H. and Patel, G. K. 2020. A novel oncostatin M/interleukin-31 receptor mutation in familial primary localized cutaneous amyloidosis. Clinical and Experimental Dermatology 45(2), pp. 254-256. (10.1111/ced.14059)
2018
- Olivero, C., Lanfredini, S., Borgogna, C., Gariglio, M. and Patel, G. K. 2018. HPV-induced field cancerisation: Transformation of adult tissue stem cell into cancer stem cell. Frontiers in Microbiology 9, article number: 546. (10.3389/fmicb.2018.00546)
- Borgogna, C. et al. 2018. β-HPV infection correlates with early stages of carcinogenesis in skin tumors and patient-derived xenografts from a kidney transplant recipient cohort. Frontiers in Microbiology 9, article number: 117. (10.3389/fmicb.2018.00117)
- Olivero, C., Morgan, H. and Patel, G. K. 2018. Identification of human cutaneous squamous cell carcinoma cancer stem cells. In: Turksen, K. ed. Skin Stem Cells., Vol. 1879. Methods in Molecular Biology Humana Press, pp. 415-433., (10.1007/7651_2018_134)
2017
- Lanfredini, S. et al. 2017. HPV8 field cancerization in a transgenic mouse model is due to Lrig1+Keratinocyte stem cell expansion. Journal of Investigative Dermatology 137(10), pp. 2208-2216. (10.1016/j.jid.2017.04.039)
- Tang, H. K. C., Lee, D. Y. H., Thompson, I., Ingram, J. R., Stone, N. and Patel, G. . K. 2017. Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. The Breast Journal 23(6), pp. 747-749. (10.1111/tbj.12910)
2015
- Hiom, S. et al. 2015. Topical delivery of gabapentin (Gaba Gel™) for neuropathic pain: a proof of concept study.. Presented at: Royal Pharmaceutical Society Annual Conference 2015, Birmingham, England, 13-14 September 2015, Vol. 23. Vol. S2. Royal Pharmaceutical Society of Great Britain pp. 46-47., (10.1111/ijpp.12213)
- Hiom, S., Patel, G., Newcombe, R. and Khot, S. 2015. Severe postherpetic neuralgia and other neuropathic pain syndromes alleviated by topical gabapentin. British Journal of Dermatology 173(1), pp. 300-302. (10.1111/bjd.13624)
- Hiom, S., Patel, G. K., Newcombe, R. G., Khot, S. and Martin, C. 2015. Severe postherpetic neuralgia and other neuropathic pain syndromes alleviated by topical gabapentin. British Journal of Dermatology 173(1), pp. 300-302. (10.1111/bjd.13624)
2013
- Colmont, C. S., Ben Ketah, A., Errington, R. J., Reed, S. H., Udey, M. C. and Patel, G. K. 2013. Human basal cell carcinoma tumor-initiating cells are resistant to etoposide [Letter]. Journal of Investigative Dermatology 134(3), pp. 867-870. (10.1038/jid.2013.377)
- Bhatti, H., Basra, M. and Patel, G. K. 2013. Hair restoration approaches for early onset male androgenetic alopecia. Journal of Cosmetic Dermatology 12(3), pp. 223-231. (10.1111/jocd.12047)
- Colmont, C. S. et al. 2013. CD200-expressing human basal cell carcinoma cells initiate tumor growth. Proceedings of the National Academy of Sciences of the United States of America 110(4), pp. 1434-1439. (10.1073/pnas.1211655110)
2012
- Colmont, C. S., Harding, K. G., Piguet, V. and Patel, G. K. 2012. Human skin cancer stem cells: a tale of mice and men. Experimental Dermatology 21(8), pp. 576-580. (10.1111/j.1600-0625.2012.01533.x)
- Patel, G. K., Yee, C. L., Yuspa, S. H. and Vogel, J. C. 2012. A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice. Journal of Investigative Dermatology 132(2), pp. 284-290. (10.1038/jid.2011.284)
- Patel, G. K., Yee, C. L., Terunuma, A., Telford, W. G., Voong, N., Yuspa, S. H. and Vogel, J. C. 2012. Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma. Journal of Investigative Dermatology 132(2), pp. 401-409. (10.1038/jid.2011.317)
2011
- Annakesavan, A., Patel, G. K. and Harding, K. G. 2011. Recurrence of diffuse large B cell lymphoma presenting as a chronic non healing wound - case report [Abstract]. Wound Repair and Regeneration 19(2), pp. A10. (10.1111/j.1524-475X.2010.00670.x)
- Richards, A. J., Hagelstein, S. M., Patel, G. K., Ivins, N. M., Sweetland, H. M. and Harding, K. G. 2011. Early use of negative pressure therapy in combination with silver dressings in a difficult breast abscess. International Wound Journal 8(6), pp. 608-611. (10.1111/j.1742-481X.2011.00838.x)
- Sanders, A. J., Jiang, D. G., Jiang, W. G., Harding, K. G. and Patel, G. K. 2011. Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. International Wound Journal 8(5), pp. 500-507. (10.1111/j.1742-481X.2011.00823.x)
- Bosanquet, D. C., Davies, W. L., May, K., Harding, K. G. and Patel, G. K. 2011. Acute generalised exanthematous pustulosis following intravitreal Ranibizumab. International Wound Journal 8(3), pp. 317-319. (10.1111/j.1742-481X.2011.00799.x)
2010
- Patel, G. K. and Harding, K. G. 2010. Nicorandil ulcer: moves beyond the mucosa. Annals of the Royal College of Surgeons of England 92(6), pp. 451-452. (10.1308/003588410X12699663905195)
- Patel, G. K., Davies, W. L., Price, P. E. and Harding, K. G. 2010. Ulcerated tophaceous gout. International Wound Journal 7(5), pp. 423-427. (10.1111/j.1742-481X.2010.00700.x)
- Ghafoor, S. Z. . A., MacRae, E. A., Harding, K. G. and Patel, G. K. 2010. Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy. International Wound Journal 7(5), pp. 418-422. (10.1111/j.1742-481X.2010.00697.x)
- Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes. Wound Repair and Regeneration 18(6), pp. 594-604. (10.1111/j.1524-475X.2010.00630.x)
- Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins, in human wound tissues and the cellular impact of WAVEs on keratinocytes [Abstract]. Wound Repair and Regeneration 18(6), pp. A84. (10.1111/j.1524-475X.2010.00633.x)
- Minhas, U., Sanders, A. J., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair and Regeneration 18(6), pp. A89. (10.1111/j.1524-475X.2010.00633.x)
- Rangaraj, A., Ye, L., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
- Rangaraj, A., Ye, L., Patel, G. K., Price, P. E., Harding, K. G. and Jiang, W. G. 2010. The molecular and cellular roles of Psoriasin (S100A4) in human cutaneous wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
2006
- Patel, G. K., Goodwin, R., Chawla, M., Laidler, P., Price, P. E., Finlay, A. Y. and Motley, R. J. 2006. Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): a randomized, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology 54(6), pp. 1025-1032. (10.1016/j.jaad.2006.01.055)
2001
- Patel, G. K. and Anstey, A. V. 2001. Rifampicin-induced lupus erythematosus. Clinical and Experimental Dermatology 26(3), pp. 260-262. (10.1046/j.1365-2230.2001.00809.x)
- Patel, G., Taylor, D. and Anstey, A. V. 2001. No need for sunscreen or occlusive dressings for benign naevi during routine phototherapy [Letter]. Photodermatology, Photoimmunology & Photomedicine 17(5), pp. 245-246. (10.1111/j.1600-0781.2001.170508.x)
Adrannau llyfrau
- Olivero, C., Morgan, H. and Patel, G. K. 2018. Identification of human cutaneous squamous cell carcinoma cancer stem cells. In: Turksen, K. ed. Skin Stem Cells., Vol. 1879. Methods in Molecular Biology Humana Press, pp. 415-433., (10.1007/7651_2018_134)
Cynadleddau
- Hiom, S. et al. 2015. Topical delivery of gabapentin (Gaba Gel™) for neuropathic pain: a proof of concept study.. Presented at: Royal Pharmaceutical Society Annual Conference 2015, Birmingham, England, 13-14 September 2015, Vol. 23. Vol. S2. Royal Pharmaceutical Society of Great Britain pp. 46-47., (10.1111/ijpp.12213)
Erthyglau
- Lovatt, C. et al. 2024. Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules. Skin Health and Disease 4(5), article number: e394. (10.1002/ski2.394)
- Morgan, H. J. et al. 2024. HPV8-induced STAT3 activation led keratinocyte stem cell expansion in human actinic keratoses. JCI Insight 9(15), article number: e177898. (10.1172/jci.insight.177898)
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
- Morgan, H. J. et al. 2020. Human basal cell carcinoma: the induction of anagen hair follicle differentiation. Clinical and Experimental Dermatology 45(3), pp. 309-317. (10.1111/ced.14108)
- Adams-Smith, R., Colmont, C., Mukhtar, A., Morgan, H. and Patel, G. K. 2020. A novel oncostatin M/interleukin-31 receptor mutation in familial primary localized cutaneous amyloidosis. Clinical and Experimental Dermatology 45(2), pp. 254-256. (10.1111/ced.14059)
- Olivero, C., Lanfredini, S., Borgogna, C., Gariglio, M. and Patel, G. K. 2018. HPV-induced field cancerisation: Transformation of adult tissue stem cell into cancer stem cell. Frontiers in Microbiology 9, article number: 546. (10.3389/fmicb.2018.00546)
- Borgogna, C. et al. 2018. β-HPV infection correlates with early stages of carcinogenesis in skin tumors and patient-derived xenografts from a kidney transplant recipient cohort. Frontiers in Microbiology 9, article number: 117. (10.3389/fmicb.2018.00117)
- Lanfredini, S. et al. 2017. HPV8 field cancerization in a transgenic mouse model is due to Lrig1+Keratinocyte stem cell expansion. Journal of Investigative Dermatology 137(10), pp. 2208-2216. (10.1016/j.jid.2017.04.039)
- Tang, H. K. C., Lee, D. Y. H., Thompson, I., Ingram, J. R., Stone, N. and Patel, G. . K. 2017. Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. The Breast Journal 23(6), pp. 747-749. (10.1111/tbj.12910)
- Hiom, S., Patel, G., Newcombe, R. and Khot, S. 2015. Severe postherpetic neuralgia and other neuropathic pain syndromes alleviated by topical gabapentin. British Journal of Dermatology 173(1), pp. 300-302. (10.1111/bjd.13624)
- Hiom, S., Patel, G. K., Newcombe, R. G., Khot, S. and Martin, C. 2015. Severe postherpetic neuralgia and other neuropathic pain syndromes alleviated by topical gabapentin. British Journal of Dermatology 173(1), pp. 300-302. (10.1111/bjd.13624)
- Colmont, C. S., Ben Ketah, A., Errington, R. J., Reed, S. H., Udey, M. C. and Patel, G. K. 2013. Human basal cell carcinoma tumor-initiating cells are resistant to etoposide [Letter]. Journal of Investigative Dermatology 134(3), pp. 867-870. (10.1038/jid.2013.377)
- Bhatti, H., Basra, M. and Patel, G. K. 2013. Hair restoration approaches for early onset male androgenetic alopecia. Journal of Cosmetic Dermatology 12(3), pp. 223-231. (10.1111/jocd.12047)
- Colmont, C. S. et al. 2013. CD200-expressing human basal cell carcinoma cells initiate tumor growth. Proceedings of the National Academy of Sciences of the United States of America 110(4), pp. 1434-1439. (10.1073/pnas.1211655110)
- Colmont, C. S., Harding, K. G., Piguet, V. and Patel, G. K. 2012. Human skin cancer stem cells: a tale of mice and men. Experimental Dermatology 21(8), pp. 576-580. (10.1111/j.1600-0625.2012.01533.x)
- Patel, G. K., Yee, C. L., Yuspa, S. H. and Vogel, J. C. 2012. A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice. Journal of Investigative Dermatology 132(2), pp. 284-290. (10.1038/jid.2011.284)
- Patel, G. K., Yee, C. L., Terunuma, A., Telford, W. G., Voong, N., Yuspa, S. H. and Vogel, J. C. 2012. Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma. Journal of Investigative Dermatology 132(2), pp. 401-409. (10.1038/jid.2011.317)
- Annakesavan, A., Patel, G. K. and Harding, K. G. 2011. Recurrence of diffuse large B cell lymphoma presenting as a chronic non healing wound - case report [Abstract]. Wound Repair and Regeneration 19(2), pp. A10. (10.1111/j.1524-475X.2010.00670.x)
- Richards, A. J., Hagelstein, S. M., Patel, G. K., Ivins, N. M., Sweetland, H. M. and Harding, K. G. 2011. Early use of negative pressure therapy in combination with silver dressings in a difficult breast abscess. International Wound Journal 8(6), pp. 608-611. (10.1111/j.1742-481X.2011.00838.x)
- Sanders, A. J., Jiang, D. G., Jiang, W. G., Harding, K. G. and Patel, G. K. 2011. Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. International Wound Journal 8(5), pp. 500-507. (10.1111/j.1742-481X.2011.00823.x)
- Bosanquet, D. C., Davies, W. L., May, K., Harding, K. G. and Patel, G. K. 2011. Acute generalised exanthematous pustulosis following intravitreal Ranibizumab. International Wound Journal 8(3), pp. 317-319. (10.1111/j.1742-481X.2011.00799.x)
- Patel, G. K. and Harding, K. G. 2010. Nicorandil ulcer: moves beyond the mucosa. Annals of the Royal College of Surgeons of England 92(6), pp. 451-452. (10.1308/003588410X12699663905195)
- Patel, G. K., Davies, W. L., Price, P. E. and Harding, K. G. 2010. Ulcerated tophaceous gout. International Wound Journal 7(5), pp. 423-427. (10.1111/j.1742-481X.2010.00700.x)
- Ghafoor, S. Z. . A., MacRae, E. A., Harding, K. G. and Patel, G. K. 2010. Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy. International Wound Journal 7(5), pp. 418-422. (10.1111/j.1742-481X.2010.00697.x)
- Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes. Wound Repair and Regeneration 18(6), pp. 594-604. (10.1111/j.1524-475X.2010.00630.x)
- Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins, in human wound tissues and the cellular impact of WAVEs on keratinocytes [Abstract]. Wound Repair and Regeneration 18(6), pp. A84. (10.1111/j.1524-475X.2010.00633.x)
- Minhas, U., Sanders, A. J., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair and Regeneration 18(6), pp. A89. (10.1111/j.1524-475X.2010.00633.x)
- Rangaraj, A., Ye, L., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
- Rangaraj, A., Ye, L., Patel, G. K., Price, P. E., Harding, K. G. and Jiang, W. G. 2010. The molecular and cellular roles of Psoriasin (S100A4) in human cutaneous wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
- Patel, G. K., Goodwin, R., Chawla, M., Laidler, P., Price, P. E., Finlay, A. Y. and Motley, R. J. 2006. Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): a randomized, double-blind, placebo-controlled trial. Journal of the American Academy of Dermatology 54(6), pp. 1025-1032. (10.1016/j.jaad.2006.01.055)
- Patel, G. K. and Anstey, A. V. 2001. Rifampicin-induced lupus erythematosus. Clinical and Experimental Dermatology 26(3), pp. 260-262. (10.1046/j.1365-2230.2001.00809.x)
- Patel, G., Taylor, D. and Anstey, A. V. 2001. No need for sunscreen or occlusive dressings for benign naevi during routine phototherapy [Letter]. Photodermatology, Photoimmunology & Photomedicine 17(5), pp. 245-246. (10.1111/j.1600-0781.2001.170508.x)
Ymchwil
The principal focus of my laboratory lies in understanding the biological basis of cancer, with a specific focus on skin cancer stem cells.
The central tenet of the cancer stem cell theory evocatively promises cure for cancer patients if a relatively small portion of cancer cells, called cancer stem cells, are efficiently killed. Conversely, therapies that target the tumour bulk and not cancer stem cells specifically risk leaving cancer stem cells behind that can re-populate the tumour bulk. Over the last decade we and others have defined the presence of cancer stem cells in 16 human malignancies as the drivers of cancer growth, typically representing <2% of tumour cells in skin cancers.
Skin cancers (basal cell carcinoma, squamous cell carcinoma and melanoma) have been the fastest growing types of cancer, and numbers will likely continue to increase. Skin cancers are the most common of all malignancies worldwide, with over 100,000 new cases per year in the UK. They represent an enormous socioeconomic burden, at a cost £500M per annum in the UK, and cause ~3000 UK deaths each year.
Skin cancers are also model tumours for the study of cancer stem cell biology since fresh human tumour tissue is readily accessible, their biology is similar to other malignancies, and that DNA mutations that give rise to these cancers can be characterised by a UV signature. We have used in vivo and in vitro assays, which we have developed, to define cancer stem cell populations in human basal cell carcinoma and human squamous cell carcinoma. In human basal cell carcinoma we have been able to show that the cancer stem cells are responsible for resistance and recurrence after conventional chemotherapy and also the recently introduced smoothened antagonists.
All the common skin cancers are notoriously resistant to chemotherapy and metastatic disease is invariably fatal. In addition to exploring drug resistance mechanism, we are currently exploring new cancer targets. While these studies are laboratory based, we also plan to begin cancer stem cell based therapeutic clinical trials in 2014.
Current grant support
- Cancer Research UK
- Welsh Assembly Government (NISCHR)
- British Skin Foundation
- Life Sciences Research Network
- Cancer Research Wales
- Commonwealth
- Hywel Dda UHB NHS R&D
