![Majd Protty MBChB (Hons), PgDip, MSc, PhD, MRCP (UK), MAcadMEd, FRCP, FESC, FACC](https://profiles-cardiff.imgix.net/attachments/2546?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Majd Protty
MBChB (Hons), PgDip, MSc, PhD, MRCP (UK), MAcadMEd, FRCP, FESC, FACC
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Majd Protty
Uwch Ddarlithydd Anrhydeddus
Trosolwg
Mae Dr Protty yn gardiolegydd ymyriadol sydd â diddordebau ymchwil mewn llid (adwaith corfforol i lidwyr niweidiol), thrombosis a haemostasis (ffurfio ceuladau mewn iechyd a chlefydau), gan ei fod yn ymwneud â chleifion sy'n dioddef o gyflyrau'r galon.
Cwblhaodd ei PhD yng Ngrŵp Lipidomeg Caerdydd yn 2021, a ariannwyd gan gymrodoriaeth Ymddiriedolaeth Wellcome GW4CAT. Yn dilyn hyn, dyfarnwyd Grant Cychwynnol iddo ar gyfer Darlithwyr Clinigol o Academi'r Gwyddorau Meddygol i ymchwilio i'r rôl y mae ffosffolipidau procoagulaidd llidiol yn ei chwarae mewn thrombosis arterial (e.e. trawiadau ar y galon). Ochr yn ochr â hyn, mae Dr Protty yn cymryd rhan weithredol mewn ymchwil sy'n cael ei yrru gan ddata sy'n ymchwilio i ganlyniadau ymyrraeth goronaidd unionsyth (PCI), gan ganolbwyntio ar weithdrefnau cymhleth, gan ddefnyddio setiau data cenedlaethol ac aml-ganolfan.
Ym mis Mawrth 2025, mae gwaith clinigol Dr Protty wedi'i leoli yn Ysbyty Athrofaol Cymru fel cardiolegydd ymyriadol ymgynghorol.
Cyhoeddiad
2026
- Costa, D. O. et al. 2026. Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.. Journal of Lipid Research 67 (8) 101093. (10.1016/j.jlr.2026.101093)
2025
- Lemor, A. et al., 2025. Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention. Cardiovascular Revascularization Medicine 81 , pp.86-94. (10.1016/j.carrev.2025.05.031)
- Sant Bakshsingh, V. , Bundhoo, S. S. and Protty, M. B. 2025. The role of enhanced stent visualization imaging in percutaneous coronary intervention: a systematic review of efficacy and clinical outcomes. Expert Review of Cardiovascular Therapy 23 (12), pp.915-921. (10.1080/14779072.2025.2574262)
- Thomas, C. P. et al. 2025. 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation. Proceedings of the National Academy of Sciences 122 (36) e2502640122. (10.1073/pnas.2502640122)
- Jaafar, M. et al., 2025. The role of cardiac magnetic resonance imaging in obstructive sleep apnea: a systematic scoping review. Journal of Clinical Sleep Medicine 21 (9), pp.1627-1638. (10.5664/jcsm.11742)
- Costa, D. O. et al. 2025. Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis.. Journal of Lipid Research 66 (7) 100842. (10.1016/j.jlr.2025.100842)
- Protty, M. B. et al. 2025. Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.. Journal of Lipid Research 66 (1) 100727. (10.1016/j.jlr.2024.100727)
- Protty, M. B. et al. 2025. Complex high-risk indicated PCI (CHIP-PCI): is it safe to let fellows-in-training perform it as primary operators?. Open Heart 12 (1) e003131. (10.1136/openhrt-2024-003131)
- Ghorasaini, M. et al., 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology. Vol. 2855, New York, NY, USA: Springer. , pp.155-169. (10.1007/978-1-0716-4116-3_10)
2024
- Kinnaird, T. et al. 2024. In-hospital outcomes of ad hoc versus planned PCI for unprotected left-main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018. Catheterization & Cardiovascular Interventions 104 (4), pp.697-706. (10.1002/ccd.31210)
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44 (9), pp.2038-2052. (10.1161/ATVBAHA.124.320902)
- Elwood, P. et al. 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130 , pp.3-8. (10.1038/s41416-023-02506-5)
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65 (1) 100484. (10.1016/j.jlr.2023.100484)
2023
- Protty, M. and Ionescu, A. 2023. The devastating impact of artificial intelligence (AI) on the traditional ways of practising imaging and cardiology are 'imagers' an endangered species, and should trainees rethink their careers?. Romanian Journal of Cardiology 33 (4), pp.134-137. (10.2478/rjc-2023-0023)
- Protty, M. et al. 2023. DIRO: Useful comparative trial on rotational vs orbital atherectomy, but there are caveats [Letter to the Editor]. JACC: Cardiovascular Interventions 16 (23) 2935. (10.1016/j.jcin.2023.10.008)
- Protty, M. B. et al. 2023. Predictors of 1- and 12-month mortality in bifurcation coronary intervention: a contemporary perspective. Future Cardiology 0 (0)(10.2217/fca-2023-0058)
- Protty, M. B. et al. 2023. Stent failure: the diagnosis and management of intracoronary stent restenosis. Expert Review of Cardiovascular Therapy 21 (7), pp.501-506. (10.1080/14779072.2023.2221852)
- Kinnaird, T. et al. 2023. Temporal trends in in-hospital outcomes following unprotected left-main percutaneous coronary intervention: an analysis of 14 522 cases from British cardiovascular intervention society database 2009 to 2017. Circulation: Cardiovascular Interventions 16 (1) e012350. (10.1161/CIRCINTERVENTIONS.122.012350)
2022
- Carande, E. J. et al., 2022. Predictors of 30 day and 12 month mortality in left main stem percutaneous coronary intervention 2016-2020: a study from two UK centers. Catheterization and Cardiovascular Interventions 100 (4), pp.585-592. (10.1002/ccd.30400)
- Elwood, P. et al. 2022. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology 12 (9) 220124. (10.1098/rsob.220124)
- Galusko, V. et al., 2022. Endoscopy findings in patients on dual antiplatelet therapy following percutaneous coronary intervention. Postgraduate Medical Journal 98 (1162), pp.591-597. (10.1136/postgradmedj-2021-139928)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63 (6) 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B. et al. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12 (4) 210318. (10.1098/rsob.210318)
- Poacher, A. T. et al., 2022. The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. Postgraduate Medical Journal 141628. (10.1136/postgradmedj-2022-141628)
- Mohee, K. et al., 2022. Comparison of an e-learning package with lecture-based teaching in the management of supraventricular tachycardia (SVT): a randomised controlled study. Postgraduate Medical Journal 98 (1157), pp.187-192. (10.1136/postgradmedj-2020-139003)
- Protty, M. B. et al. 2022. The impact of intracoronary imaging on PCI outcomes in cases utilising rotational atherectomy: an analysis of 8,417 rotational atherectomy cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology 2022 5879187. (10.1155/2022/5879187)
- Ding, W. Y. et al., 2022. Relationship between lipoproteins, thrombosis and atrial fibrillation. Cardiovascular Research 118 (3), pp.716-731. (10.1093/cvr/cvab017)
- Protty, M. et al. 2022. Brachial arterial access for PCI: an analysis of the British Cardiovascular Intervention Society database. Eurointervention 17 (13), pp.1100-1103. (10.4244/EIJ-D-21-00294)
- Protty, M. et al. 2022. Defining percutaneous coronary intervention complexity and risk. JACC: Cardiovascular Interventions 15 (1), pp.39-49. (10.1016/j.jcin.2021.09.039)
2021
- Malik, N. et al., 2021. The status quo of gastroenterology training in the UK. The Lancet Gastroenterology & Hepatology 6 (10) 781. (10.1016/S2468-1253(21)00234-X)
- AL RAISI, S. et al., 2021. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry. Minerva Cardiology and Angiology 69 (4), pp.408-416. (10.23736/S2724-5683.21.05591-5)
- Protty, M. B. et al. 2021. Rotational atherectomy complicated by coronary perforation is associated with poor outcomes: analysis of 10,980 cases from the British Cardiovascular Intervention Society database. Cardiovascular Revascularization Medicine 28 , pp.9-13. (10.1016/j.carrev.2020.07.040)
- Kinnaird, T. et al. 2021. Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database. JACC: Cardiovascular Interventions 14 (13), pp.1423-1430. (10.1016/j.jcin.2021.04.034)
- Protty, M. B. et al. 2021. Combined use of rotational and excimer lASER coronary atherectomy ( RASER ) during complex coronary angioplasty-An analysis of cases (2006-2016) from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97 (7), pp.E911-E918. (10.1002/ccd.29377)
- Protty, M. B. et al. 2021. Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies. European Heart Journal: Case Reports 5 (5) ytab181. (10.1093/ehjcr/ytab181)
- Protty, M. B. et al. 2021. Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97 (5), pp.E653-E660. (10.1002/ccd.29251)
- Hussain, H. I. et al., 2021. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97 (2), pp.E179-E185. (10.1002/ccd.28933)
- Elwood, P. C. et al. 2021. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. ecancermedicalscience 15 1258. (10.3332/ecancer.2021.1258)
- Protty, M. 2021. Characterising the role of inflammatory procoagulant phospholipids in arterial thrombosis. PhD Thesis , Cardiff University.
- Yin, W. L. et al., 2021. Review of implementation of the universal variable rate insulin infusion (VRII) chart introduced at the Royal Gwent Hospital based on Rowan Hillson Inpatient Safety Award 2019 (Joint British Diabetes Societies guidelines) [Abstract]. Diabetic Medicine 38 (S1) P86.
2020
- Elwood, P. C. et al., 2020. Better than any pill - and no side effects! Healthy lifestyles, statins and aspirin. Lifestyle Medecine 1 (1) e4. (10.1002/lim2.4)
- Galusko, V. et al., 2020. The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost [Letter]. Scandinavian Cardiovascular Journal 54 (6), pp.383-384. (10.1080/14017431.2020.1775879)
- Borna, S. et al., 2020. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Journal of Cellular and Molecular Medicine 24 (2), pp.1980-1992. (10.1111/jcmm.14895)
2019
- Mohee, K. et al., 2019. Impact of social deprivation on outcome following transcatheter aortic valve implantation (TAVI). Open Heart 6 (2) e001089. (10.1136/openhrt-2019-001089)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16), pp.8038-8047. (10.1073/pnas.1814409116)
- Protty, M. B. 2019. Coronary artery disease and schizophrenia: the interplay of heart and mind. European Heart Journal - Quality of Care and Clinical Outcomes 5 (2), pp.90-91. (10.1093/ehjqcco/qcz005)
- Verhemel, S. et al., 2019. De-differentiated myxofibrosarcoma metastasis in the right atrium. JACC: Case Reports 1 (2), pp.151-155. (10.1016/j.jaccas.2019.06.021)
2018
- Protty, M. B. et al. 2018. Prescribing patterns of oral antiplatelets in Wales: evolving trends from 2005 to 2016. Future Cardiology 14 (4), pp.277-282. (10.2217/fca-2018-0003)
2017
- Protty, M. B. et al. 2017. Securing a cardiology speciality training programme in the UK: how did other people do it?. Postgraduate Medical Journal 94 (1109), pp.155-158. (10.1136/postgradmedj-2017-135199)
- Protty, M. et al. 2017. The liver as the homeostatic alarm: abnormal liver function tests precede the onset of diabetes mellitusby more than two years. Gut 66 (S2), pp.A172. (10.1136/gutjnl-2017-314472.336)
- Protty, M. et al. 2017. Older (higher risk) patients with non-st-elevation acute coronary syndrome (NSTEACS) have the most to gain from invasive therapy: a population study in South Wales 2004–2014. Presented at: British Cardiovascular Society (BCS) Annual Conference 2017 Manchester, UK 5–7 June 2017. Heart. Vol. 103.BMJ Publishing Group. , pp.A48-A49. (10.1136/heartjnl-2017-311726.63)
- Protty, M. B. et al. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236 , pp.5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M. , Haboubi, H. and Yeoman, A. 2017. Changes in the Model for End-Stage Liver Disease (MELD) scores on day 7 predict mortality in acute on chronic liver disease: the delta-MELD project. Presented at: The International Liver Congress 2017 Amsterdam, Netherlands 19-23 April 2017. Journal of Hepatology. Vol. 66.Vol. S1. Elsevier. , pp.S387-S387. (10.1016/S0168-8278(17)31124-8)
- Protty, M. B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42 (2), pp.132-134. (10.1111/jcpt.12481)
- Protty, M. B. et al. 2017. Statins for secondary prevention: clinical use in patients with acute coronary syndrome in Wales. Future Cardiology 13 (2), pp.137-141. (10.2217/fca-2016-0060)
2016
- Protty, M. B. et al. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205 (11), pp.523-525. (10.5694/mja16.00870)
- Freeman, P. M. et al. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3 (1) e000414. (10.1136/openhrt-2016-000414)
- Protty, M. B. et al. 2016. Statins for primary prevention in practice: clinical use in Wales and the NICE guideline effect [Letter]. British Journal of Clinical Pharmacology 82 (3), pp.892-894. (10.1111/bcp.13014)
2015
- Androshchuk, V. et al. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: Transcatheter Cardiovascular Therapeutics 2015 (tct2015) San Francisco, USA 11-15 October 2015. Journal of the American College of Cardiology. Vol. 66.Vol. 15. Elsevier. , pp.B68-B68. (10.1016/j.jacc.2015.08.196)
- Androshchuk, V. et al. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: British Cardiovascular Society (BCS) Annual Conference 2015 Manchester, UK 8-10 June 2015. Vol. 101.BMJ Publishing Group. , pp.A68-A68. (10.1136/heartjnl-2015-308066.118)
- Protty, M. B. et al. 2015. The debate over mechanical thromboprophylaxis after hip fracture: time to choose sides. Presented at: British Geriatrics Society Autumn Meeting Brighton, UK 15–17 October 2014. Age and Ageing. Vol. 44.Oxford University Press (OUP). , pp.i12-i12. (10.1093/ageing/afv032.04)
- Protty, M. et al. 2015. Severe symptomatic aortic stenosis: medical treatment versus Transcatheter Aortic Valve Implantation: a real world analysis of admission profiles, cost, and mortality using the Secure Anonymised Information Linkage (SAIL) databank. Presented at: American College of Cardiology / i2 Annual Scientific Session (ACC-i2) San Diego, USA 14-16 March 2015. Journal of the American College of Cardiology. Vol. 65.Vol. 10. Elsevier. , pp.A1867-A1867. (10.1016/S0735-1097(15)61867-8)
- Protty, M. B. et al. 2015. Mechanical prophylaxis after hip fracture: what is the risk of deep vein thrombosis? A retrospective observational study. BMJ Open 5 (2) e006956. (10.1136/bmjopen-2014-006956)
- Sako, Z. et al., 2015. Postal consent for gastrointestinal endoscopy: a patient based analysis. Presented at: Irish Society Of Gastroentrology Summer Meeting Naas, Ireland 12-13 June 2014. Vol. 184.Springer Verlag. , pp.S97-S98.
2013
- Protty, M. B. et al. 2013. Students as teachers: The impact of a near-peer-led didactic teaching model on tutee confidence. Medical Teacher 35 (11), pp.968. (10.3109/0142159X.2013.786814)
2009
- Mumford, A. D. et al., 2009. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood 115 (2), pp.363-369. (10.1182/blood-2009-08-236976)
- Protty, M. et al. 2009. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochemical Journal 417 (1), pp.391-401. (10.1042/BJ20081126)
2008
- Orgel, J. P. et al., 2008. Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE 3 (11) e3793. (10.1371/journal.pone.0003793)
2007
- Dhanjal, T. S. et al., 2007. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 109 (10), pp.4237-4244. (10.1182/blood-2006-10-050740)
Adrannau llyfrau
- Ghorasaini, M. et al., 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology. Vol. 2855, New York, NY, USA: Springer. , pp.155-169. (10.1007/978-1-0716-4116-3_10)
Cynadleddau
- Protty, M. et al. 2017. Older (higher risk) patients with non-st-elevation acute coronary syndrome (NSTEACS) have the most to gain from invasive therapy: a population study in South Wales 2004–2014. Presented at: British Cardiovascular Society (BCS) Annual Conference 2017 Manchester, UK 5–7 June 2017. Heart. Vol. 103.BMJ Publishing Group. , pp.A48-A49. (10.1136/heartjnl-2017-311726.63)
- Protty, M. , Haboubi, H. and Yeoman, A. 2017. Changes in the Model for End-Stage Liver Disease (MELD) scores on day 7 predict mortality in acute on chronic liver disease: the delta-MELD project. Presented at: The International Liver Congress 2017 Amsterdam, Netherlands 19-23 April 2017. Journal of Hepatology. Vol. 66.Vol. S1. Elsevier. , pp.S387-S387. (10.1016/S0168-8278(17)31124-8)
- Androshchuk, V. et al. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: Transcatheter Cardiovascular Therapeutics 2015 (tct2015) San Francisco, USA 11-15 October 2015. Journal of the American College of Cardiology. Vol. 66.Vol. 15. Elsevier. , pp.B68-B68. (10.1016/j.jacc.2015.08.196)
- Androshchuk, V. et al. 2015. Repeat coronary angiography in patients with previously normal coronary arteries. Presented at: British Cardiovascular Society (BCS) Annual Conference 2015 Manchester, UK 8-10 June 2015. Vol. 101.BMJ Publishing Group. , pp.A68-A68. (10.1136/heartjnl-2015-308066.118)
- Protty, M. B. et al. 2015. The debate over mechanical thromboprophylaxis after hip fracture: time to choose sides. Presented at: British Geriatrics Society Autumn Meeting Brighton, UK 15–17 October 2014. Age and Ageing. Vol. 44.Oxford University Press (OUP). , pp.i12-i12. (10.1093/ageing/afv032.04)
- Protty, M. et al. 2015. Severe symptomatic aortic stenosis: medical treatment versus Transcatheter Aortic Valve Implantation: a real world analysis of admission profiles, cost, and mortality using the Secure Anonymised Information Linkage (SAIL) databank. Presented at: American College of Cardiology / i2 Annual Scientific Session (ACC-i2) San Diego, USA 14-16 March 2015. Journal of the American College of Cardiology. Vol. 65.Vol. 10. Elsevier. , pp.A1867-A1867. (10.1016/S0735-1097(15)61867-8)
- Sako, Z. et al., 2015. Postal consent for gastrointestinal endoscopy: a patient based analysis. Presented at: Irish Society Of Gastroentrology Summer Meeting Naas, Ireland 12-13 June 2014. Vol. 184.Springer Verlag. , pp.S97-S98.
Erthyglau
- Costa, D. O. et al. 2026. Interleukin-6 stimulates platelet 12-lipoxygenase to drive coagulation in inflammatory arthritis.. Journal of Lipid Research 67 (8) 101093. (10.1016/j.jlr.2026.101093)
- Lemor, A. et al., 2025. Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention. Cardiovascular Revascularization Medicine 81 , pp.86-94. (10.1016/j.carrev.2025.05.031)
- Sant Bakshsingh, V. , Bundhoo, S. S. and Protty, M. B. 2025. The role of enhanced stent visualization imaging in percutaneous coronary intervention: a systematic review of efficacy and clinical outcomes. Expert Review of Cardiovascular Therapy 23 (12), pp.915-921. (10.1080/14779072.2025.2574262)
- Thomas, C. P. et al. 2025. 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation. Proceedings of the National Academy of Sciences 122 (36) e2502640122. (10.1073/pnas.2502640122)
- Jaafar, M. et al., 2025. The role of cardiac magnetic resonance imaging in obstructive sleep apnea: a systematic scoping review. Journal of Clinical Sleep Medicine 21 (9), pp.1627-1638. (10.5664/jcsm.11742)
- Costa, D. O. et al. 2025. Circulating membrane aminophospholipids contribute to thrombotic risk in rheumatoid arthritis.. Journal of Lipid Research 66 (7) 100842. (10.1016/j.jlr.2025.100842)
- Protty, M. B. et al. 2025. Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3.. Journal of Lipid Research 66 (1) 100727. (10.1016/j.jlr.2024.100727)
- Protty, M. B. et al. 2025. Complex high-risk indicated PCI (CHIP-PCI): is it safe to let fellows-in-training perform it as primary operators?. Open Heart 12 (1) e003131. (10.1136/openhrt-2024-003131)
- Kinnaird, T. et al. 2024. In-hospital outcomes of ad hoc versus planned PCI for unprotected left-main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018. Catheterization & Cardiovascular Interventions 104 (4), pp.697-706. (10.1002/ccd.31210)
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44 (9), pp.2038-2052. (10.1161/ATVBAHA.124.320902)
- Elwood, P. et al. 2024. Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against. British Journal of Cancer 130 , pp.3-8. (10.1038/s41416-023-02506-5)
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65 (1) 100484. (10.1016/j.jlr.2023.100484)
- Protty, M. and Ionescu, A. 2023. The devastating impact of artificial intelligence (AI) on the traditional ways of practising imaging and cardiology are 'imagers' an endangered species, and should trainees rethink their careers?. Romanian Journal of Cardiology 33 (4), pp.134-137. (10.2478/rjc-2023-0023)
- Protty, M. et al. 2023. DIRO: Useful comparative trial on rotational vs orbital atherectomy, but there are caveats [Letter to the Editor]. JACC: Cardiovascular Interventions 16 (23) 2935. (10.1016/j.jcin.2023.10.008)
- Protty, M. B. et al. 2023. Predictors of 1- and 12-month mortality in bifurcation coronary intervention: a contemporary perspective. Future Cardiology 0 (0)(10.2217/fca-2023-0058)
- Protty, M. B. et al. 2023. Stent failure: the diagnosis and management of intracoronary stent restenosis. Expert Review of Cardiovascular Therapy 21 (7), pp.501-506. (10.1080/14779072.2023.2221852)
- Kinnaird, T. et al. 2023. Temporal trends in in-hospital outcomes following unprotected left-main percutaneous coronary intervention: an analysis of 14 522 cases from British cardiovascular intervention society database 2009 to 2017. Circulation: Cardiovascular Interventions 16 (1) e012350. (10.1161/CIRCINTERVENTIONS.122.012350)
- Carande, E. J. et al., 2022. Predictors of 30 day and 12 month mortality in left main stem percutaneous coronary intervention 2016-2020: a study from two UK centers. Catheterization and Cardiovascular Interventions 100 (4), pp.585-592. (10.1002/ccd.30400)
- Elwood, P. et al. 2022. Aspirin and cancer: biological mechanisms and clinical outcomes. Open Biology 12 (9) 220124. (10.1098/rsob.220124)
- Galusko, V. et al., 2022. Endoscopy findings in patients on dual antiplatelet therapy following percutaneous coronary intervention. Postgraduate Medical Journal 98 (1162), pp.591-597. (10.1136/postgradmedj-2021-139928)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63 (6) 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B. et al. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12 (4) 210318. (10.1098/rsob.210318)
- Poacher, A. T. et al., 2022. The impact of adopting low-molecular-weight heparin in place of aspirin as routine thromboprophylaxis for patients with hip fracture. Postgraduate Medical Journal 141628. (10.1136/postgradmedj-2022-141628)
- Mohee, K. et al., 2022. Comparison of an e-learning package with lecture-based teaching in the management of supraventricular tachycardia (SVT): a randomised controlled study. Postgraduate Medical Journal 98 (1157), pp.187-192. (10.1136/postgradmedj-2020-139003)
- Protty, M. B. et al. 2022. The impact of intracoronary imaging on PCI outcomes in cases utilising rotational atherectomy: an analysis of 8,417 rotational atherectomy cases from the British Cardiovascular Intervention Society Database. Journal of Interventional Cardiology 2022 5879187. (10.1155/2022/5879187)
- Ding, W. Y. et al., 2022. Relationship between lipoproteins, thrombosis and atrial fibrillation. Cardiovascular Research 118 (3), pp.716-731. (10.1093/cvr/cvab017)
- Protty, M. et al. 2022. Brachial arterial access for PCI: an analysis of the British Cardiovascular Intervention Society database. Eurointervention 17 (13), pp.1100-1103. (10.4244/EIJ-D-21-00294)
- Protty, M. et al. 2022. Defining percutaneous coronary intervention complexity and risk. JACC: Cardiovascular Interventions 15 (1), pp.39-49. (10.1016/j.jcin.2021.09.039)
- Malik, N. et al., 2021. The status quo of gastroenterology training in the UK. The Lancet Gastroenterology & Hepatology 6 (10) 781. (10.1016/S2468-1253(21)00234-X)
- AL RAISI, S. et al., 2021. Ticagrelor versus prasugrel in acute coronary syndrome: sex-specific analysis from the RENAMI Registry. Minerva Cardiology and Angiology 69 (4), pp.408-416. (10.23736/S2724-5683.21.05591-5)
- Protty, M. B. et al. 2021. Rotational atherectomy complicated by coronary perforation is associated with poor outcomes: analysis of 10,980 cases from the British Cardiovascular Intervention Society database. Cardiovascular Revascularization Medicine 28 , pp.9-13. (10.1016/j.carrev.2020.07.040)
- Kinnaird, T. et al. 2021. Operator volumes and in-hospital outcomes: an analysis of 7,740 rotational atherectomy procedures from the BCIS national database. JACC: Cardiovascular Interventions 14 (13), pp.1423-1430. (10.1016/j.jcin.2021.04.034)
- Protty, M. B. et al. 2021. Combined use of rotational and excimer lASER coronary atherectomy ( RASER ) during complex coronary angioplasty-An analysis of cases (2006-2016) from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97 (7), pp.E911-E918. (10.1002/ccd.29377)
- Protty, M. B. et al. 2021. Case series of iatrogenic coronary stent avulsion: a rare complication with varied management strategies. European Heart Journal: Case Reports 5 (5) ytab181. (10.1093/ehjcr/ytab181)
- Protty, M. B. et al. 2021. Excimer laser coronary atherectomy during complex PCI: An analysis of 1,471 laser cases from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97 (5), pp.E653-E660. (10.1002/ccd.29251)
- Hussain, H. I. et al., 2021. The impact of coronary perforation in percutaneous interventions involving the left main stem coronary artery in the United Kingdom 2007-2014: Insights from the British Cardiovascular Intervention Society database. Catheterization and Cardiovascular Interventions 97 (2), pp.E179-E185. (10.1002/ccd.28933)
- Elwood, P. C. et al. 2021. Aspirin and cancer survival: a systematic review and meta-analyses of 118 observational studies of aspirin and 18 cancers. ecancermedicalscience 15 1258. (10.3332/ecancer.2021.1258)
- Yin, W. L. et al., 2021. Review of implementation of the universal variable rate insulin infusion (VRII) chart introduced at the Royal Gwent Hospital based on Rowan Hillson Inpatient Safety Award 2019 (Joint British Diabetes Societies guidelines) [Abstract]. Diabetic Medicine 38 (S1) P86.
- Elwood, P. C. et al., 2020. Better than any pill - and no side effects! Healthy lifestyles, statins and aspirin. Lifestyle Medecine 1 (1) e4. (10.1002/lim2.4)
- Galusko, V. et al., 2020. The quest for a radial lounge: StatSeal™ reduces transradial coronary angiography turn-around time and cost [Letter]. Scandinavian Cardiovascular Journal 54 (6), pp.383-384. (10.1080/14017431.2020.1775879)
- Borna, S. et al., 2020. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Journal of Cellular and Molecular Medicine 24 (2), pp.1980-1992. (10.1111/jcmm.14895)
- Mohee, K. et al., 2019. Impact of social deprivation on outcome following transcatheter aortic valve implantation (TAVI). Open Heart 6 (2) e001089. (10.1136/openhrt-2019-001089)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16), pp.8038-8047. (10.1073/pnas.1814409116)
- Protty, M. B. 2019. Coronary artery disease and schizophrenia: the interplay of heart and mind. European Heart Journal - Quality of Care and Clinical Outcomes 5 (2), pp.90-91. (10.1093/ehjqcco/qcz005)
- Verhemel, S. et al., 2019. De-differentiated myxofibrosarcoma metastasis in the right atrium. JACC: Case Reports 1 (2), pp.151-155. (10.1016/j.jaccas.2019.06.021)
- Protty, M. B. et al. 2018. Prescribing patterns of oral antiplatelets in Wales: evolving trends from 2005 to 2016. Future Cardiology 14 (4), pp.277-282. (10.2217/fca-2018-0003)
- Protty, M. B. et al. 2017. Securing a cardiology speciality training programme in the UK: how did other people do it?. Postgraduate Medical Journal 94 (1109), pp.155-158. (10.1136/postgradmedj-2017-135199)
- Protty, M. et al. 2017. The liver as the homeostatic alarm: abnormal liver function tests precede the onset of diabetes mellitusby more than two years. Gut 66 (S2), pp.A172. (10.1136/gutjnl-2017-314472.336)
- Protty, M. B. et al. 2017. Increased morbidity, mortality and length of in-hospital stay for patients with acute coronary syndrome with pre-morbid psychiatric diagnoses. International Journal of Cardiology 236 , pp.5-8. (10.1016/j.ijcard.2017.01.067)
- Protty, M. B. and Hayes, J. 2017. Dawn of the direct-acting oral anticoagulants: trends in oral anticoagulant prescribing in Wales 2009-2015. Journal of Clinical Pharmacy and Therapeutics 42 (2), pp.132-134. (10.1111/jcpt.12481)
- Protty, M. B. et al. 2017. Statins for secondary prevention: clinical use in patients with acute coronary syndrome in Wales. Future Cardiology 13 (2), pp.137-141. (10.2217/fca-2016-0060)
- Protty, M. B. et al. 2016. Acute coronary syndrome on Friday the 13th: a case for re-organising services?. The Medical Journal of Australia 205 (11), pp.523-525. (10.5694/mja16.00870)
- Freeman, P. M. et al. 2016. Severe symptomatic aortic stenosis: medical therapy and transcatheter aortic valve implantation (TAVI)- a real-world retrospective cohort analysis of outcomes and cost-effectiveness using national data. Open Heart 3 (1) e000414. (10.1136/openhrt-2016-000414)
- Protty, M. B. et al. 2016. Statins for primary prevention in practice: clinical use in Wales and the NICE guideline effect [Letter]. British Journal of Clinical Pharmacology 82 (3), pp.892-894. (10.1111/bcp.13014)
- Protty, M. B. et al. 2015. Mechanical prophylaxis after hip fracture: what is the risk of deep vein thrombosis? A retrospective observational study. BMJ Open 5 (2) e006956. (10.1136/bmjopen-2014-006956)
- Protty, M. B. et al. 2013. Students as teachers: The impact of a near-peer-led didactic teaching model on tutee confidence. Medical Teacher 35 (11), pp.968. (10.3109/0142159X.2013.786814)
- Mumford, A. D. et al., 2009. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood 115 (2), pp.363-369. (10.1182/blood-2009-08-236976)
- Protty, M. et al. 2009. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochemical Journal 417 (1), pp.391-401. (10.1042/BJ20081126)
- Orgel, J. P. et al., 2008. Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE 3 (11) e3793. (10.1371/journal.pone.0003793)
- Dhanjal, T. S. et al., 2007. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 109 (10), pp.4237-4244. (10.1182/blood-2006-10-050740)
Gosodiad
- Protty, M. 2021. Characterising the role of inflammatory procoagulant phospholipids in arterial thrombosis. PhD Thesis , Cardiff University.
Ymchwil
Clefyd cardiofasgwlaidd (y galon) yw prif achos marwolaeth yn y DU. Mae cleifion â chlefyd y galon sy'n profi trawiad ar y galon mewn mwy o berygl o ddioddef trawiad ar y galon, strôc neu farwolaeth arall. Mae trawiadau ar y galon yn digwydd o ganlyniad i rwystrau mewn rhydwelïau ar y galon. Mae'r rhwystrau hyn yn cael eu hachosi gan lid (adwaith i llidus niweidiol) ac yn arwain at actifadu celloedd gwaed fel celloedd gwyn (sy'n gyfrifol am wella clwyfau) a phlatennau (sy'n gyfrifol am geulo gwaed) sydd yn ei dro yn arwain at geulo a rhwystrau annormal mewn rhydwelïau. Mae'r driniaeth ar gyfer y cyflyrau hyn yn cynnwys therapi gwrth-thrombotig (fel aspirin) a gweithdrefnau i agor blociau mewn rhydwelïau coronaidd (fel angioplasti a stentio).
Thema 1: Llid, Lipidau a Thrombosis
Mae ceulo gwaed yn digwydd trwy ryngweithio proteinau gwaed â brasterau penodol (ffosffolipidau) sy'n bresennol ar wyneb celloedd gwaed ac sy'n gysylltiedig â llid. Nid yw eu rôl bosibl wrth yrru digwyddiadau ceulo annormal mewn trawiadau ar y galon yn hysbys. Os caiff ei adnabod, gall fod yn driniaeth newydd bosibl. Mae hyn yn bwysig gan fod un o bob deg claf sy'n profi trawiad ar y galon yn parhau i fod mewn perygl o ddatblygu trawiad arall ar y galon, strôc, neu farw er gwaethaf y driniaeth bresennol.
Mae ymchwil Dr Protty yn y thema hon yn canolbwyntio ar y proffil ffosffolipid a gynhyrchir gan gelloedd gwaed mewn cleifion â chlefyd y galon, gyda'r nod o adnabod gyrwyr ceulo yn y cleifion hyn, a datblygu targedau triniaeth newydd.
Thema 2: Ymchwil sy'n cael ei yrru gan ddata i amlafiachedd cardiofasgwlaidd a chanlyniadau
Mae Dr Protty yn cymryd rhan weithredol mewn ymchwil sy'n cael ei yrru gan ddata sy'n ymchwilio i ganlyniadau ymyrraeth goronaidd (PCI), gan ganolbwyntio ar weithdrefnau cymhleth, gan ddefnyddio setiau data cenedlaethol ac aml-ganolfan.
Mae'r thema hon wedi galluogi Dr Protty i gyfrannu at y maes trwy ddatblygu offer haenu risg (megis UK -BCIS CHIP Score) ac astudio cymhlethdodau prin o angioplasti na fyddai fel arall yn bosibl heb ddefnyddio cronfeydd data mawr o ymyriadau a chanlyniadau coronaidd. Mae'r gwaith hwn yn rhan o gydweithrediad mwy sy'n cynnwys cydweithwyr yng Nghymru, y DU ac yn fyd-eang.
Addysgu
- Mentor/Goruchwyliwr ar gyfer Echocardiograffeg y Galon FUSIC (FICE / FUSIC) (2018-)
- Uwch Hyfforddwr Cynnal Bywyd (ALS), Cyngor Resus (DU) (2017-)
- Tiwtor Coleg Cyswllt (RCP), Bwrdd Iechyd Prifysgol Aneurin Bevan (2015-17)
- Aelod o'r Grŵp Ysgrifennu Cwestiwn (Blwyddyn 1/2) a'r Bwrdd Craffu Arholiadau (Blwyddyn 3), Prifysgol Caerdydd (2013-14)
Bywgraffiad
Dechreuodd ymrwymiad Dr Protty i'r byd academaidd pan oedd yn 18 oed. Gohiriodd ei gynnig i astudio meddygaeth am dair blynedd i weithio gyda Dr Mike Tomlinson (Birmingham) mewn labordy gwyddorau cardiofasgwlaidd sy'n arwain y byd dan arweiniad yr Athro Steve Watson (Birmingham). Yn ystod y cyfnod hwn, ymchwiliodd Dr Protty i lwybrau signalau cymhleth platennau a'r rôl y maent yn ei chwarae mewn anhwylderau thrombotig a gwaedu.
Yn dilyn hyn, dechreuodd Dr Protty ei hyfforddiant meddygol ym Mhrifysgol Birmingham lle parhaodd i fynd ar drywydd cyfleoedd ymchwil. Mae hyn yn enghraifft orau o gael Ysgoloriaeth Gwyliau Biofeddygol Ymddiriedolaeth Wellcome i gynnal ymchwil ar aptamers RNA gwrth-HIV ym Mhrifysgol Rhydychen (Yr Athro William James). Graddiodd Dr Protty y cwrs MBChB (meddygaeth glinigol) yn 2013 gydag anrhydedd, tri anrhydedd a 15 gwobr genedlaethol a lleol.
Yn dilyn hynny, symudodd Dr Protty i Gymru ar ôl iddo gael ei benodi i'r rhaglen sylfaen academaidd hynod gystadleuol yng Nghaerdydd. Yn ystod y cyfnod hwn, parhaodd â'i daith mewn cardioleg academaidd a dyfarnwyd gradd MSc iddo (Prifysgol Caerdydd) mewn therapiwteg gyda rhagoriaeth, gan astudio'r defnydd o therapi gostwng lipidau mewn cleifion sy'n dioddef o glefyd cardiofasgwlaidd yng Nghymru.
Dechreuodd Dr Protty ei hyfforddiant cardioleg arbenigol ar ôl cael ei benodi i gynllun Trac Academaidd Clinigol Cymru (WCAT) yn 2015. Fel rhan o'r cynllun hwn, datblygodd Dr Protty gysylltiadau â grŵp Lipidomeg Caerdydd (Yr Athro Valerie O'Donnell/Yr Athro Peter Collins) a gwnaeth gais yn llwyddiannus i gynllun GW4CAT Ymddiriedolaeth Wellcome i ddilyn gradd PhD (Dyfarnwyd 2021).
Yn ôl-ddoethurol, parhaodd Dr Protty ar gynllun WCAT fel cofrestrydd cardioleg academaidd clnical, gan ganolbwyntio ar rôl ffosffolipidau proceulo mewn thrombosis rhydwelïol gyda'r nod o nodi targedau therapiwtig gwrth-thrombotig newydd i wella gofal cleifion â chlefyd cardiofasgwlaidd. Ochr yn ochr â hyn, mae Dr Protty yn cymryd rhan weithredol mewn ymchwil sy'n cael ei yrru gan ddata sy'n ymchwilio i ganlyniadau ymyrraeth coronaidd percutaneous (PCI), gyda ffocws ar weithdrefnau cymhleth, gan ddefnyddio setiau data cenedlaethol ac aml-ganolfan.
Ym mis Mawrth 2025, mae gwaith clinigol Dr Protty wedi'i leoli yn Ysbyty Athrofaol Cymru fel cardiolegydd ymyriadol ymgynghorol. Cafodd ei ethol yn gymrawd Coleg Brenhinol Meddygon Caeredin (FRCP) a Chymdeithas Cardioleg Ewrop (FESC) i gydnabod ei gyflawniadau hyd yma.
Anrhydeddau a dyfarniadau
- 2017 Crynodeb Safle Uchaf yng nghategori ACS, Cynhadledd Flynyddol Cymdeithas Cardiofasgwlaidd Prydain
- Gwobr Ymchwil W T Edwards 2017, Cymdeithas Feddygol Caerdydd, Ebrill 2017
- Gwobr Ymchwilydd Ifanc 2017, Cyngres yr Afu Ryngwladol 2017, EASL
- Enillydd Gwobr y Canghellor 2013 – dyfernir y wobr glodfawr hon yn flynyddol i fyfyriwr aeddfed y mae ei gynnydd academaidd a'i berfformiad drwy gydol y cwrs wedi bod yn rhagorol ac sydd hefyd wedi gwneud cyfraniad rhagorol i fywyd cyffredinol y Brifysgol gyfan, Prifysgol Birmingham.
- 2013 Gwobr Israddedig BPS mewn Ffarmacoleg Glinigol, Cymdeithas Ffarmacolegol Prydain
- 2013 Enillydd Gwobr Goffa Arthur Foxwell mewn Meddygaeth – a ddyfarnwyd i'r myfyriwr sydd â'r sgôr uchaf mewn Meddygaeth Glinigol, Prifysgol Birmingham
- 2013 Cwpan y Gymdeithas Feddygol, Prifysgol Birmingham
- 2012 Ysgoloriaeth Teithio Dewisol Ymddiriedolaeth Myfyrwyr Meddygol a Deintyddol Prydain (BMDST)
- 2012 Ysgoloriaeth Teithio Dewisol Ymddiriedolaeth Arthur Thomson, Prifysgol Birmingham
- Gwobr Gyntaf 2011 am Wobr Leith Neumann mewn Astudiaethau Patholegol, Prifysgol Birmingham
- Gwobr 2011 am y cyflwyniad llafar gorau yn y sesiwn imiwnoleg yng Nghynhadledd Ryngwladol LIMSC, Prifysgol Leiden, NL
- 2010 Ysgoloriaeth Gwyliau Biofeddygol Ymddiriedolaeth Wellcome, i ariannu prosiect ymchwil ym Mhrifysgol Rhydychen.
Aelodaethau proffesiynol
- Cymrawd Cymdeithas Cardioleg Ewrop (FESC)
- Cymrawd Coleg Brenhinol Meddygon Caeredin (FRCP)
- Cardiolegydd ymyrriadol ardystiedig Cymdeithas Ewropeaidd PCI (EAPCI)
- Cymdeithas Cardiofasgwlaidd Prydain (BCS)
- Cymdeithas Ecocardiograffeg Prydain (BSE) - Achrediad llawn mewn ecocardiograffeg trawsthorasig
- Cymdeithas Ymyrraeth Cardiofasgwlaidd Prydain (BCIS) - Cyd-olygydd
- Cymdeithas Feddygol Prydain (BMA)
- Cyngor Meddygol Cyffredinol (GMC)
- Aelod o Goleg Brenhinol y Meddygon (MRCP Llundain)
- Aelod o Academi'r Addysgwyr Meddygol (MAcadMEd)
Safleoedd academaidd blaenorol
- Arholwr Allanol PhD Viva (2025-)
Pwyllgorau ac adolygu
- Aelod o Bwyllgor Staff Academaidd Meddygol BMA (MASC), 2019-2021
- Cynrychiolydd Cymru i Gymdeithas Cardiolegwyr Iau Prydain (BJCA), 2020-
- Adolygydd Grant - MRC, Croesawu 2018-
- Adolygydd Cyfnodolyn - Platennau, EHJ QCCO, BMJ Open, JACC, IJCP, Swyddogaeth, ICR3
- Pwyllgor addysg ar gyfer hyfforddeion meddygon, Bwrdd Iechyd Prifysgol Aneurin Bevan 2015-2017
Contact Details
[email protected]
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Cardioleg
- Clefydau cardiofasgwlaidd
- Lipids
- Thrombosis
- Platennau