![Pierre Rizkallah](https://profiles-cardiff.imgix.net/attachments/2585?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Pierre Rizkallah
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Pierre Rizkallah
Cymrawd RCUK
Trosolwyg
Rwy'n uwch ddarlithydd mewn Bioleg Strwythurol. Rwy'n arbenigo mewn astudio siapiau moleciwlau biolegol ar y lefel atomig, i gasglu ffyrdd a mecanweithiau rhyngweithio rhwng gwahanol foleciwlau bywyd. Rwyf wedi cynnal ymchwil mewn llawer o wahanol feysydd Gwyddorau Bywyd, gan roi dealltwriaeth o gyfathrebu biolegol mewn amrywiaeth o systemau. Agorodd hyn y gallu i ddylunio therapïau ar gyfer gwahanol gwynion, maes wrth wraidd fy ymchwil. Mae hefyd yn gyfle i ddylunio diagnosteg ac i ddefnyddio biotechnoleg i alluogi prosesau nad ydynt yn digwydd yn naturiol.
Rwy'n raddedig mewn Cemeg, ar lefel BSc a PhD. Rwy'n defnyddio cymwysiadau Ffiseg i astudio macromoleciwlau biolegol. Mae gen i brofiad helaeth gyda crisialog pelydr-X a phenderfynu strwythur 3D gan ddefnyddio ymbelydredd syncrotron. Rwyf wedi defnyddio'r technegau cysylltiedig o Small Angle X-ray Scattering (SAXS) a Circular Dichroism (CD) i daflu goleuni ar fecanweithiau biolegol.
Rwyf wedi gwasanaethu ar bwyllgorau a chymryd rhan mewn rhaglenni ar lefel genedlaethol a rhyngwladol. Rwyf wedi cynnal llawer o ymarferion allgymorth a chyfryngau yn ystod fy ngyrfa, gan gyfathrebu perthnasedd uniongyrchol a phwysigrwydd Gwyddoniaeth mewn bywyd bob dydd.
Cefais gyfnod byr o brofiad yn y diwydiant colur, gan arwain tîm llinell gynhyrchu.
Cyhoeddiad
2024
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
- Owens, H. A. et al. 2024. Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood brain barrier function. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20(3), pp. 2016-2033. (10.1002/alz.13603)
- Hulin-Curtis, S. et al. 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43(6), article number: 114259. (10.1016/j.celrep.2024.114259)
2023
- Williamson, L. J. et al. 2023. Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX. Proceedings of the National Academy of Sciences 120(49), article number: e2203241120. (10.1073/pnas.2203241120)
- Mundy, R. M. et al. 2023. Broad sialic acid usage amongst species D human adenovirus. npj Viruses 1, article number: 1. (10.1038/s44298-023-00001-5)
- Chen, Y. et al. 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42(8), article number: 112827. (10.1016/j.celrep.2023.112827)
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)
2022
- Best, H. L., Williamson, L. J., Lipka-Lloyd, M., Waller-Evans, H., Lloyd-Evans, E., Rizkallah, P. J. and Berry, C. 2022. The crystal structure of Bacillus thuringiensis Tpp80Aa1 and its interaction with galactose-containing glycolipids. Toxins 14(12), article number: 863. (10.3390/toxins14120863)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Bates, E. A. et al. 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25, pp. 43-56. (10.1016/j.omto.2022.03.007)
- Noby, N. et al. 2022. Structure-guided engineering of a family IV cold-adapted esterase expands its substrate range. International Journal of Molecular Sciences 23(9), article number: 4703. (10.3390/ijms23094703)
2021
- Noby, N. et al. 2021. Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism. Open Biology 11(12), article number: 210182. (10.1098/rsob.210182)
- Baker, A. T. et al. 2021. ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome. Science Advances 7(49), article number: eabl8213. (10.1126/sciadv.abl8213)
- Griffiths, J. S. et al. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224(7), pp. 1219-1224. (10.1093/infdis/jiab145)
- Man, S. et al. 2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. The Journal of Immunology 207(4), pp. 1009-1017. (10.4049/jimmunol.2000756)
- Worthy, H. L. et al. 2021. The crystal sructure of Bacillus cereus HblL1. Toxins 13(4), article number: 253. (10.3390/toxins13040253)
- Baker, A. T. et al. 2021. The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism. Journal of Virology 95(4), article number: e01849-20. (10.1128/JVI.01849-20)
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8(1), article number: 2003167. (10.1002/advs.202003167)
2020
- Mowbray, N. G. et al. 2020. Safe management of surgical smoke in the age of COVID-19. British Journal of Surgery 107(11), pp. 1406-1413. (10.1002/bjs.11679)
- Bovay, A. et al. 2020. Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222 by combinatorial peptide library screening. Molecular Immunology 125, pp. 43-50. (10.1016/j.molimm.2020.06.025)
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
- Holland, C. J. et al. 2020. Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA. Journal of Clinical Investigation 130(5), pp. 2673–2688. (10.1172/JCI130562)
- Cresser-Brown, J., Rizkallah, P., Jin, Y., Roth, C., Miller, D. J. and Allemann, R. K. 2020. An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. Acta Crystallographica Section F: Structural Biology Communications 76(2), pp. 81-85. (10.1107/S2053230X20001181)
2019
- MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2, article number: 83. (10.1038/s42004-019-0185-5)
- Madura, F. et al. 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49(7), pp. 1052-1066. (10.1002/eji.201948085)
- Kalvaitis, M. E., Johnson, L. A., Mart, R. J., Rizkallah, P. and Allemann, R. K. 2019. A noncanonical chromophore reveals structural rearrangements of the light-oxygen-voltage domain upon photoactivation. Biochemistry 58(22), pp. 2608-2616. (10.1021/acs.biochem.9b00255)
- Scott, A. F., Cresser-Brown, J., Williams, T. L., Rizkallah, P. J., Jin, Y., Luk, L. Y. and Allemann, R. K. 2019. Crystal structure and biophysical analysis of furfural detoxifying aldehyde reductase from clostridium beijerinkii. Applied and Environmental Microbiology (10.1128/AEM.00978-19)
- Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10, article number: 319. (10.3389/fimmu.2019.00319)
- Baker, A. T. et al. 2019. Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. Nature Communications 10, article number: 741. (10.1038/s41467-019-08599-y)
2018
- Uusi-Kerttula, H. et al. 2018. Ad5NULL-A20 - a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies. Clinical Cancer Research 24(17), pp. 4215-4224. (10.1158/1078-0432.CCR-18-1089)
- Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14(5), article number: e1007017. (10.1371/journal.ppat.1007017)
- Holland, C. J. et al. 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9, article number: 674. (10.3389/fimmu.2018.00674)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
- Bovay, A. et al. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48(2), pp. 258-272. (10.1002/eji.201747082)
2017
- Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8, article number: 1503. (10.3389/fimmu.2017.01503)
- MacLachlan, B. J. et al. 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments(120), article number: e54991. (10.3791/54991)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
2016
- Nomikos, M. et al. 2016. Mutations in PLCd1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function. FEBS Journal 283(24), pp. 4502-4514. (10.1111/febs.13939)
- Hartley, A. M., Worthy, H. L., Reddington, S. C., Rizkallah, P. J. and Jones, D. D. 2016. Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle. Chemical Science 7(10), pp. 6484-6491. (10.1039/C6SC00944A)
- Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126(6), pp. 2191-2204. (10.1172/JCI85679)
- Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291(17), pp. 8951-8959. (10.1074/jbc.M115.707414)
- Raman, M. C. C. et al. 2016. Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Scientific Reports 6, article number: 18851. (10.1038/srep18851)
2015
- Adams, S., Robinson, E., Miller, D. J., Rizkallah, P., Hallett, M. B. and Allemann, R. K. 2015. Conformationally restricted calpain inhibitors. Chemical Science 6(12), pp. 6865-6871. (10.1039/c5sc01158b)
- Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290(31), pp. 18924-18933. (10.1074/jbc.M114.622522)
- Reid, R., Redman, J. E., Rizkallah, P., Fegan, C. D., Pepper, C. J. and Man, S. T. 2015. CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification. Immunology 144(3), pp. 495-505. (10.1111/imm.12398)
- Madura, F. et al. 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45(2), pp. 584-591. (10.1002/eji.201445114)
- Reddington, S. C., Driezis, S., Hartley, A. M., Watson, P. D., Rizkallah, P. J. and Jones, D. D. 2015. Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein. RSC Advances 5(95), pp. 77734-77738. (10.1039/C5RA13552D)
- Kløverpris, H. N. et al. 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12(1), article number: 20. (10.1186/s12977-015-0149-5)
2014
- Adams, S. E., Rizkallah, P., Miller, D. J., Robinson, E. J., Hallett, M. B. and Allemann, R. K. 2014. The structural basis of differential inhibition of human calpain by indole and phenyl α--mercaptoacrylic acids. Journal of Structural Biology 187(3), pp. 236-241. (10.1016/j.jsb.2014.07.004)
- Nomikos, M. et al. 2014. Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death. Febs Letters 588(17), pp. 2898-2902. (10.1016/j.febslet.2014.07.007)
- Arpino, J. J., Reddington, S. C., Halliwell, L., Rizkallah, P. and Jones, D. D. 2014. Random single amino acid deletion sampling unveils structural tolerance and the benefits of helical registry shift on GFP folding and structure. Structure 22(6), pp. 889-898. (10.1016/j.str.2014.03.014)
- Motozono, C. et al. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192(7), pp. 3428-3434. (10.4049/jimmunol.1302667)
- Arpino, J. A. J., Rizkallah, P. and Jones, D. D. 2014. Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein. Acta Crystallographica Section D Biological Crystallography 70(8), pp. 2152-2162. (10.1107/S139900471401267X)
2013
- Cole, D. et al. 2013. Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking mode. Frontiers in Immunology 4, article number: 168. (10.3389/fimmu.2013.00168)
- Reddington, S. C., Rizkallah, P., Watson, P. D., Pearson, R., Tippmann, E. M. and Jones, D. D. 2013. Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence. Angewandte Chemie - International Edition 52(23), pp. 5974-5977. (10.1002/anie.201301490)
- Madura, F. et al. 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288(26), pp. 18766-18775. (10.1074/jbc.M113.464560)
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Cole, D. et al. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289(2), pp. 628-638. (10.1074/jbc.M113.522110)
- Reddington, S. C., Watson, P. D., Rizkallah, P., Tippmann, E. M. and Jones, D. D. 2013. Genetically encoding phenyl azide chemistry: new uses and ideas for classical biochemistry. Biochemical Society Transactions 41(5), pp. 1177-1182. (10.1042/BST20130094)
2012
- Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Holland, C. J. et al. 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2, article number: 629. (10.1038/srep00629)
- Bulek, A. M. et al. 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382(1-2), pp. 203-210. (10.1016/j.jim.2012.06.007)
- Yang, S. et al. 2012. A partially interpenetrated metal-organic framework for selective hysteretic sorption of carbon dioxide. Nature Materials 11(8), pp. 710-716. (10.1038/nmat3343)
- Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Tadesse, H., Blake, A. J., Champness, N. R., Warren, J. E., Rizkallah, P. and Licence, P. 2012. Supramolecular architectures of symmetrical dicationic ionic liquid based systems. Crystengcomm 14(15), pp. 4886-4893. (10.1039/c2ce25106j)
- Arpino, J., Rizkallah, P. and Jones, D. D. 2012. Crystal structure of enhanced green fluorescent protein to 1.35 Å resolution reveals alternative conformations for Glu222. PLoS ONE 7(10), article number: e47132. (10.1371/journal.pone.0047132)
2011
- Lane, S. W., Dennis, C. A., Lane, C. L., Trinh, C. H., Rizkallah, P., Stockley, P. G. and Phillips, S. E. V. 2011. Construction and crystal structure of recombinant STNV capsids. Journal of Molecular Biology 413(1), pp. 41-50. (10.1016/j.jmb.2011.07.062)
2010
- Ronson, T. K., Carruthers, C., Fisher, J., Brotin, T., Harding, L. P., Rizkallah, P. and Hardie, M. J. 2010. Tripodal 4-pyridyl-derived host ligands and their metallo-supramolecular chemistry: stella octangula and bowl-shaped assemblies. Inorganic Chemistry -American Chemical Society- 49(2), pp. 675-685. (10.1021/ic901972h)
- Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6(11), article number: e1001198. (10.1371/journal.ppat.1001198)
2009
- Ronson, T. K., Fisher, J., Harding, L. P., Rizkallah, P., Warren, J. E. and Hardie, M. J. 2009. Stellated polyhedral assembly of a topologically complicated Pd4L4 'Solomon cube'. Nature Chemistry 1(3), pp. 212-216. (10.1038/nchem.213)
- Cole, D. et al. 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284(40), article number: 27281-27289. (10.1074/jbc.M109.022509)
2008
- Govada, L. et al. 2008. Crystal structure of the C1 domain of cardiac myosin binding protein-C: Implications for hypertrophic cardiomyopathy. Journal of Molecular Biology 378(2), pp. 387-397. (10.1016/j.jmb.2008.02.044)
- Westcott, A., Fisher, J., Harding, L. P., Rizkallah, P. and Hardie, M. J. 2008. Self-assembly of a 3-D triply interlocked chiral [2] catenane. Journal of the American Chemical Society 130(10), pp. 2950-2951. (10.1021/ja8002149)
2007
- Cole, D. et al. 2007. Computational design and crystal structure of an enhanced affinity mutant human CD8 αα coreceptor. Proteins: Structure, Function and Bioinformatics 67(1), pp. 65-74. (10.1002/prot.21176)
2006
- Cole, D. et al. 2006. Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology 36(1), pp. 170-179. (10.1002/eji.200535424)
2005
- Cole, D. et al. 2005. Crystallization and preliminary X-ray structural studies of a high-affinity CD8αα co-receptor to pMHC. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61(3), pp. 285-287. (10.1107/S1744309105002988)
Articles
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
- Owens, H. A. et al. 2024. Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood brain barrier function. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20(3), pp. 2016-2033. (10.1002/alz.13603)
- Hulin-Curtis, S. et al. 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43(6), article number: 114259. (10.1016/j.celrep.2024.114259)
- Williamson, L. J. et al. 2023. Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX. Proceedings of the National Academy of Sciences 120(49), article number: e2203241120. (10.1073/pnas.2203241120)
- Mundy, R. M. et al. 2023. Broad sialic acid usage amongst species D human adenovirus. npj Viruses 1, article number: 1. (10.1038/s44298-023-00001-5)
- Chen, Y. et al. 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42(8), article number: 112827. (10.1016/j.celrep.2023.112827)
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)
- Best, H. L., Williamson, L. J., Lipka-Lloyd, M., Waller-Evans, H., Lloyd-Evans, E., Rizkallah, P. J. and Berry, C. 2022. The crystal structure of Bacillus thuringiensis Tpp80Aa1 and its interaction with galactose-containing glycolipids. Toxins 14(12), article number: 863. (10.3390/toxins14120863)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Bates, E. A. et al. 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25, pp. 43-56. (10.1016/j.omto.2022.03.007)
- Noby, N. et al. 2022. Structure-guided engineering of a family IV cold-adapted esterase expands its substrate range. International Journal of Molecular Sciences 23(9), article number: 4703. (10.3390/ijms23094703)
- Noby, N. et al. 2021. Structure and in silico simulations of a cold-active esterase reveals its prime cold-adaptation mechanism. Open Biology 11(12), article number: 210182. (10.1098/rsob.210182)
- Baker, A. T. et al. 2021. ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome. Science Advances 7(49), article number: eabl8213. (10.1126/sciadv.abl8213)
- Griffiths, J. S. et al. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224(7), pp. 1219-1224. (10.1093/infdis/jiab145)
- Man, S. et al. 2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. The Journal of Immunology 207(4), pp. 1009-1017. (10.4049/jimmunol.2000756)
- Worthy, H. L. et al. 2021. The crystal sructure of Bacillus cereus HblL1. Toxins 13(4), article number: 253. (10.3390/toxins13040253)
- Baker, A. T. et al. 2021. The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism. Journal of Virology 95(4), article number: e01849-20. (10.1128/JVI.01849-20)
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8(1), article number: 2003167. (10.1002/advs.202003167)
- Mowbray, N. G. et al. 2020. Safe management of surgical smoke in the age of COVID-19. British Journal of Surgery 107(11), pp. 1406-1413. (10.1002/bjs.11679)
- Bovay, A. et al. 2020. Identification of a superagonist variant of the immunodominant Yellow fever virus epitope NS4b214-222 by combinatorial peptide library screening. Molecular Immunology 125, pp. 43-50. (10.1016/j.molimm.2020.06.025)
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
- Holland, C. J. et al. 2020. Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA. Journal of Clinical Investigation 130(5), pp. 2673–2688. (10.1172/JCI130562)
- Cresser-Brown, J., Rizkallah, P., Jin, Y., Roth, C., Miller, D. J. and Allemann, R. K. 2020. An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. Acta Crystallographica Section F: Structural Biology Communications 76(2), pp. 81-85. (10.1107/S2053230X20001181)
- MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2, article number: 83. (10.1038/s42004-019-0185-5)
- Madura, F. et al. 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49(7), pp. 1052-1066. (10.1002/eji.201948085)
- Kalvaitis, M. E., Johnson, L. A., Mart, R. J., Rizkallah, P. and Allemann, R. K. 2019. A noncanonical chromophore reveals structural rearrangements of the light-oxygen-voltage domain upon photoactivation. Biochemistry 58(22), pp. 2608-2616. (10.1021/acs.biochem.9b00255)
- Scott, A. F., Cresser-Brown, J., Williams, T. L., Rizkallah, P. J., Jin, Y., Luk, L. Y. and Allemann, R. K. 2019. Crystal structure and biophysical analysis of furfural detoxifying aldehyde reductase from clostridium beijerinkii. Applied and Environmental Microbiology (10.1128/AEM.00978-19)
- Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10, article number: 319. (10.3389/fimmu.2019.00319)
- Baker, A. T. et al. 2019. Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions. Nature Communications 10, article number: 741. (10.1038/s41467-019-08599-y)
- Uusi-Kerttula, H. et al. 2018. Ad5NULL-A20 - a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies. Clinical Cancer Research 24(17), pp. 4215-4224. (10.1158/1078-0432.CCR-18-1089)
- Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14(5), article number: e1007017. (10.1371/journal.ppat.1007017)
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- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
- Bovay, A. et al. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48(2), pp. 258-272. (10.1002/eji.201747082)
- Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8, article number: 1503. (10.3389/fimmu.2017.01503)
- MacLachlan, B. J. et al. 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments(120), article number: e54991. (10.3791/54991)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
- Nomikos, M. et al. 2016. Mutations in PLCd1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function. FEBS Journal 283(24), pp. 4502-4514. (10.1111/febs.13939)
- Hartley, A. M., Worthy, H. L., Reddington, S. C., Rizkallah, P. J. and Jones, D. D. 2016. Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle. Chemical Science 7(10), pp. 6484-6491. (10.1039/C6SC00944A)
- Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126(6), pp. 2191-2204. (10.1172/JCI85679)
- Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291(17), pp. 8951-8959. (10.1074/jbc.M115.707414)
- Raman, M. C. C. et al. 2016. Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. Scientific Reports 6, article number: 18851. (10.1038/srep18851)
- Adams, S., Robinson, E., Miller, D. J., Rizkallah, P., Hallett, M. B. and Allemann, R. K. 2015. Conformationally restricted calpain inhibitors. Chemical Science 6(12), pp. 6865-6871. (10.1039/c5sc01158b)
- Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290(31), pp. 18924-18933. (10.1074/jbc.M114.622522)
- Reid, R., Redman, J. E., Rizkallah, P., Fegan, C. D., Pepper, C. J. and Man, S. T. 2015. CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification. Immunology 144(3), pp. 495-505. (10.1111/imm.12398)
- Madura, F. et al. 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45(2), pp. 584-591. (10.1002/eji.201445114)
- Reddington, S. C., Driezis, S., Hartley, A. M., Watson, P. D., Rizkallah, P. J. and Jones, D. D. 2015. Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein. RSC Advances 5(95), pp. 77734-77738. (10.1039/C5RA13552D)
- Kløverpris, H. N. et al. 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12(1), article number: 20. (10.1186/s12977-015-0149-5)
- Adams, S. E., Rizkallah, P., Miller, D. J., Robinson, E. J., Hallett, M. B. and Allemann, R. K. 2014. The structural basis of differential inhibition of human calpain by indole and phenyl α--mercaptoacrylic acids. Journal of Structural Biology 187(3), pp. 236-241. (10.1016/j.jsb.2014.07.004)
- Nomikos, M. et al. 2014. Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death. Febs Letters 588(17), pp. 2898-2902. (10.1016/j.febslet.2014.07.007)
- Arpino, J. J., Reddington, S. C., Halliwell, L., Rizkallah, P. and Jones, D. D. 2014. Random single amino acid deletion sampling unveils structural tolerance and the benefits of helical registry shift on GFP folding and structure. Structure 22(6), pp. 889-898. (10.1016/j.str.2014.03.014)
- Motozono, C. et al. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192(7), pp. 3428-3434. (10.4049/jimmunol.1302667)
- Arpino, J. A. J., Rizkallah, P. and Jones, D. D. 2014. Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein. Acta Crystallographica Section D Biological Crystallography 70(8), pp. 2152-2162. (10.1107/S139900471401267X)
- Cole, D. et al. 2013. Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking mode. Frontiers in Immunology 4, article number: 168. (10.3389/fimmu.2013.00168)
- Reddington, S. C., Rizkallah, P., Watson, P. D., Pearson, R., Tippmann, E. M. and Jones, D. D. 2013. Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence. Angewandte Chemie - International Edition 52(23), pp. 5974-5977. (10.1002/anie.201301490)
- Madura, F. et al. 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288(26), pp. 18766-18775. (10.1074/jbc.M113.464560)
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Cole, D. et al. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289(2), pp. 628-638. (10.1074/jbc.M113.522110)
- Reddington, S. C., Watson, P. D., Rizkallah, P., Tippmann, E. M. and Jones, D. D. 2013. Genetically encoding phenyl azide chemistry: new uses and ideas for classical biochemistry. Biochemical Society Transactions 41(5), pp. 1177-1182. (10.1042/BST20130094)
- Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
- Holland, C. J. et al. 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2, article number: 629. (10.1038/srep00629)
- Bulek, A. M. et al. 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382(1-2), pp. 203-210. (10.1016/j.jim.2012.06.007)
- Yang, S. et al. 2012. A partially interpenetrated metal-organic framework for selective hysteretic sorption of carbon dioxide. Nature Materials 11(8), pp. 710-716. (10.1038/nmat3343)
- Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
- Tadesse, H., Blake, A. J., Champness, N. R., Warren, J. E., Rizkallah, P. and Licence, P. 2012. Supramolecular architectures of symmetrical dicationic ionic liquid based systems. Crystengcomm 14(15), pp. 4886-4893. (10.1039/c2ce25106j)
- Arpino, J., Rizkallah, P. and Jones, D. D. 2012. Crystal structure of enhanced green fluorescent protein to 1.35 Å resolution reveals alternative conformations for Glu222. PLoS ONE 7(10), article number: e47132. (10.1371/journal.pone.0047132)
- Lane, S. W., Dennis, C. A., Lane, C. L., Trinh, C. H., Rizkallah, P., Stockley, P. G. and Phillips, S. E. V. 2011. Construction and crystal structure of recombinant STNV capsids. Journal of Molecular Biology 413(1), pp. 41-50. (10.1016/j.jmb.2011.07.062)
- Ronson, T. K., Carruthers, C., Fisher, J., Brotin, T., Harding, L. P., Rizkallah, P. and Hardie, M. J. 2010. Tripodal 4-pyridyl-derived host ligands and their metallo-supramolecular chemistry: stella octangula and bowl-shaped assemblies. Inorganic Chemistry -American Chemical Society- 49(2), pp. 675-685. (10.1021/ic901972h)
- Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6(11), article number: e1001198. (10.1371/journal.ppat.1001198)
- Ronson, T. K., Fisher, J., Harding, L. P., Rizkallah, P., Warren, J. E. and Hardie, M. J. 2009. Stellated polyhedral assembly of a topologically complicated Pd4L4 'Solomon cube'. Nature Chemistry 1(3), pp. 212-216. (10.1038/nchem.213)
- Cole, D. et al. 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284(40), article number: 27281-27289. (10.1074/jbc.M109.022509)
- Govada, L. et al. 2008. Crystal structure of the C1 domain of cardiac myosin binding protein-C: Implications for hypertrophic cardiomyopathy. Journal of Molecular Biology 378(2), pp. 387-397. (10.1016/j.jmb.2008.02.044)
- Westcott, A., Fisher, J., Harding, L. P., Rizkallah, P. and Hardie, M. J. 2008. Self-assembly of a 3-D triply interlocked chiral [2] catenane. Journal of the American Chemical Society 130(10), pp. 2950-2951. (10.1021/ja8002149)
- Cole, D. et al. 2007. Computational design and crystal structure of an enhanced affinity mutant human CD8 αα coreceptor. Proteins: Structure, Function and Bioinformatics 67(1), pp. 65-74. (10.1002/prot.21176)
- Cole, D. et al. 2006. Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European Journal of Immunology 36(1), pp. 170-179. (10.1002/eji.200535424)
- Cole, D. et al. 2005. Crystallization and preliminary X-ray structural studies of a high-affinity CD8αα co-receptor to pMHC. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 61(3), pp. 285-287. (10.1107/S1744309105002988)
Ymchwil
- Modiwleiddio Adenofirws ar gyfer Oncotherapi: Rydym wedi tanseilio'r pathogen adenofirws naturiol i fod yn gyfrwng cyflenwi ar gyfer epitopau canser penodol a all godi imiwnedd yn erbyn y canserau hyn. Mae'r firws yn cael ei wneud yn gyntaf heb ei amlhau trwy gael gwared ar yr exons dyblygu, yna mae darn byr o niwcleotidau codio yn cael eu mewnosod ar bwynt strategol yn y protein targot ar sruface y firws i ddynwared rhan o'r protein sy'n gysylltiedig â chanser. Pan fydd y celloedd targed wedi'u heintio, mae'r epitop yn cael ei fynegi ac mae'r system imiwnedd yn cael ei symud i'w adnabod, gan ymosod ar bob cell malaen. Rydym wedi defnyddio penderfyniad strwythur yn helaeth i gael gwybodaeth am y strategaeth orau i'w defnyddio yn yr ymdrech hon, gyda thua 20 o gofnodion newydd i'r banc data protein. Cydweithio â grŵp yr Athro Alan Parker yn yr Ysgol Feddygaeth, Prifysgol Caerdydd.
- Proteinau'r System Imiwnedd: Nod y gwaith hwn yw pennu'r ffactorau strwythurol sy'n gysylltiedig â chroes-adweithedd derbynyddion celloedd sy'n deillio o Thymus, TCRs, pan fyddant yn adnabod mwy nag un antigen a gyflwynir yng nghyd-destun y cymhleth Histocompatibility Mawr, mecanwaith sy'n sail i awtoimiwnedd. Ail agwedd yw dirywiad rhwymo TCR i wahanol antigenau a gyflwynir gan un MHC i ganiatáu cwmpas eang o antigenau posibl gyda'r nifer cyfyngedig o MHCs sydd gan unigolyn. Mae'r prosiect yn cynnwys defnyddio crisialog pelydr-X i ddatrys strwythurau 3D o'r endidau hyn, a chynnal astudiaethau rhwymo gyda chyseiniant plasmon wyneb, calorimetri titration isothermol ac actifadu celloedd T naïf. Cydweithio â'r Grŵp Modiwleiddio Celloedd T dan arweiniad yr Athro Andrew Sewell, yn y Sefydliad Heintiau ac Imiwnoleg, Prifysgol Caerdydd.
- Proteinau Fuorescent Gwyrdd Gwell: Mae'r protein fflwroleuol gwyrdd o Aequoris victoria yn cael ei ddefnyddio ar hyn o bryd mewn llawer o gymwysiadau biolegol a biotechnolegol i helpu i fapio dosbarthiad endidau biolegol mewn celloedd, trwy ei atodi i wrthgyrff a godwyd yn erbyn moleciwlau o ddiddordeb. Ar ôl rhwymo, mae'r GFP sy'n cario gwrthgyrff yn fflworoleuo ar donfeddi penodol. Nod rhaglen o beirianneg genetig y GFP o'r pysgodyn slefrod môr Aequoria victoria yw gwella ei briodweddau fflworoleuedd ar gyfer gwelededd gwell. Cydweithio â Dr Dafydd Jones yn Ysgol y Biowyddorau ym Mhrifysgol Caerdydd.
- Tocsinau Pryfleiddiad Bacteriol Naturiol: Rydym yn astudio tocsinau naturiol amrywiol a gynhyrchir gan Bacillus thuringiensis ac organebau tebyg i ddeall eu dull gweithredu ac i ddatblygu plaladdwyr sy'n gyfeillgar i'r amgylchedd y gellir eu targedu at blâu penodol. Cydweithio â'r Athro Colin Berry yn yr Ysgol Bioscineces ym Mhrifysgol Caerdydd.
- Dyluniad Atalydd Calpain: Mae Calpain yn caspase aml-barth sy'n ymwneud ag ymateb i lid. Mae'n helpu celloedd gwaed gwyn i newid siâp i groesi trwy feinwe epithelial ger safleoedd llid. Mae gormod o weithgaredd yn gysylltiedig ag arthrhitis ar ôl lefel ymateb uwch. Roedd atal Parth VI wedi'i gyflawni yn y gorffennol, mewn mannau eraill, gan weithio gyda'r ensym moch. Yma, rydym yn gweithio ar yr ensym dynol, gan geisio optimeiddio'r atalydd ar gyfer affinedd uwch a gwell cydnabyddiaeth. Cydweithio â thîm dan arweiniad yr Athro Ruedi Allemann yn yr Ysgol Cemeg, Prifysgol Caerdydd.
- Biocoloration mewn cragen cimychiaid: Datryswyd strwythur β-crystacyanin, y protein lliw mewn cragen cimychiaid, gan ddefnyddio pelydr-X meddalach i ddata diffreithiant cam. Mae'r strwythur yn amlinellu'r mecanwaith lle mae golau yn cael ei anghyfreithloni a'i fodiwleiddio gan y protein i effeithio ar allyriad gwahanol yn y sbectrwm gweladwy trwy ddylanwadu ar gydffurfiad y cromoffor astaxanthin sy'n cael ei rwymo gan y protein. Datblygwyd methodoleg newydd i ddefnyddio'r signal anomalaidd o atomau S er mwyn datrys y strwythur. Cydweithrediad â'r Athro John Helliwell, Prifysgol Manceinion.
- Cydnabyddiaeth Carbohydradau: Astudiwyd rhwymo swbstradau carbohydradau gan wahanol lectinau yn y prosiect hwn. Astudiwyd y dull o rwymo canghennau mannos oligomarig gan lectins monocot a rhwymo swcros gan lectinau legime. Cydweithrediad â'r Athro Colin Reynolds, Prifysgol John Moores Lerpwl.
- Proteinau Gwenwyn Neidr: Astudiwyd a-niwrotocsin y cobra kign Naja kaouthia a haemorragin Bothrops jararaca mewn cydweithrediad â'r Athro RDG Theakston, Ysgol Meddygaeth Drofannol Lerpwl.
Addysgu
- Cyflwyniad i fodiwl Bioleg Strwythurol mewn cwrs MSc Biowybodeg
- Bioleg Strwythurol ar gyfer israddedigion Meddygol, fel cydran a ddewiswyd gan fyfyriwr
- Mentora myfyrwyr meddygol israddedig
Bywgraffiad
Addysg
- 1984: PhD Cemeg, Prifysgol Nottingham, y DU
- 1979: BSc Cemeg, Prifysgol Libanus, Beirut, Libanus
Trosolwg o'r Gyrfa
- Uwch Ddarlithydd / Uwch Gymrawd RCUK, Prifysgol Caerdydd, ers Rhagfyr 2008
- Rheolwr Cyfleuster Crisialog Protein, Ffynhonnell Ymbelydredd Synchrotron, Daresbury, y DU. 19 Chwef 1990 - 30 Medi 2008
- Uwch Swyddog Gwyddonol, Cyngor Ymchwil Amaethyddiaeth a Bwyd, Reading, y DU. 2 Ion - 15 Chwef 1990
- Uwch Gymrawd Ymchwil, Prifysgol Lerpwl a Labordy Daresbury, y DU. 1 Tach 1987- 31 Rhag 1989
- Cynorthwyydd Ymchwil Ôl-ddoethurol, Prifysgol Leeds, y DU. 1 Rhag 1984 - 30 Medi 1987
- Rheolwr Llinell Gynhyrchu, Gwneuthurwyr Cosmetics Rhyngwladol SAL, Beirut, Libanus. 1 Medi 1979 - 31 Awst 1980
Pwyllgorau
- Trysorydd, Grŵp Strwythurau Biolegol Cymdeithas Grisialog Prydain, 2008-2017
- Pwyllgor Cynghorwyr Gwyddonol, prosiect Synchrotron SESAME, y Dwyrain Canol, 2000-2004
- Fforwm Defnyddwyr Ymbelydredd Synchrotron, 1997-2007
- Ysgrifennydd y Panel Dyrannu Beamtime, SRS Daresbury, 1990-1995
Meysydd goruchwyliaeth
Cyllid newydd fel cyd-oruchwyliwr i fyfyriwr, gan ddechrau ym mis Hydref 2021, i astudio adenofirysau.
Ymgysylltu
Cardiff University Structural Biology Network
Coordinating meetings to discuss matters related to the topic of Structural Biology. Presentations by visiting scientists or members of Cardiff University.
Cardiff University Beamtime Allocation Group at Diamond
Coordinating access to the facilities at the Diamond Light Source National Facility at Harwell, for X-ray crystallography, Small Angle X-ray Scattering, Circular Dichroism spectroscopy, Biological Imaging, etc.
Contact Details
RizkallahP@caerdydd.ac.uk
+44 652248
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell 3/05, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
+44 652248
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell 3/05, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN