Dr Jason Webber

2024

• Bordanaba-Florit, G., Royo, F., Alboniga, O. E., Clayton, A., Falcon-Perez, J. M. and Webber, J. 2024. Integration of proteomic and metabolomic analysis reveal distinct metabolic alterations of prostate cancer-associated fibroblasts compared to normal fibroblasts from patient's stroma samples. BBA - Molecular Basis of Disease 1870(6), article number: 167229. (10.1016/j.bbadis.2024.167229)

2023

• Bhaoighill, M. N., Falcón-Pérez, J. M., Royo, F., Tee, A., Webber, J. and Dunlop, E. 2023. Tuberous Sclerosis Complex cell-derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers. Journal of Extracellular Vesicles 12(6), article number: 12336. (10.1002/jev2.12336)

2021

• Lanning, B., Webber, J., Uysal-Ongane, P., Jiang, W. G., Clayton, A. and Dart, D. A. 2021. Prostate cancer cell extracellular vesicles increase mineralisation of bone osteoblast precursor cells in an in vitro model. Biology 10(4), article number: 318. (10.3390/biology10040318)

2020

• Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15(10), article number: e0240189. (10.1371/journal.pone.0240189)
• Bliss, C. M. et al. 2020. Targeting antigen to the surface of EVs improves the in vivo immunogenicity of human and non-human adenoviral vaccines in mice. Molecular Therapy - Methods and Clinical Development 16, pp. 108-125. (10.1016/j.omtm.2019.12.003)

2018

• Théry, C. et al. 2018. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles 7(1), article number: 1535750. (10.1080/20013078.2018.1535750)
• Clayton, A. et al. 2018. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles 7(1), article number: 1473707. (10.1080/20013078.2018.1473707)
• Yeung, V. et al. 2018. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma. Nanoscale 10(18), pp. 8547-8559. (10.1039/C8NR02417K)

2017

• Roberts-Dalton, H. D. et al. 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9(36), pp. 13693-13706. (10.1039/C7NR04128D)
• Salimu, J., Webber, J., Gurney, M., Al-Taei, S., Clayton, A. and Tabi, Z. 2017. Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes. Journal of Extracellular Vesicles 6(1), article number: 1368823. (10.1080/20013078.2017.1368823)

2016

• Welton, J. . L. et al. 2016. Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array. Journal of Extracellular Vesicles 5, article number: 31209. (10.3402/jev.v5.31209)
• Webber, J. P., Spary, L. K., Mason, M. D., Tabi, Z., Brewis, I. A. and Clayton, A. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7, pp. 20124-20139. (10.18632/oncotarget.7716)

2015

• Webber, J. P., Yeung, V. and Clayton, A. 2015. Extracellular vesicles as modulators of the cancer microenvironment. Seminars in Cell and Developmental Biology 40, pp. 27-34. (10.1016/j.semcdb.2015.01.013)
• Welton, J. L., Webber, J. P., Botos, L., Jones, M. and Clayton, A. 2015. Ready-made chromatography columns for extracellular vesicle isolation from plasma. Journal of Extracellular Vesicles 4, article number: 27269. (10.3402/jev.v4.27269)
• Chowdhury, R., Webber, J. P., Gurney, M., Mason, M. D., Tabi, Z. and Clayton, A. 2015. Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts. Oncotarget 6(2), pp. 715-731. (10.18632/oncotarget.2711)
• Webber, J. P. et al. 2015. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34(3), pp. 290-302. (10.1038/onc.2013.560)

2014

• Spary, L. K., Salimu, J., Webber, J. P., Clayton, A., Mason, M. d. and Tabi, Z. 2014. Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+PD-L1+phenotype in prostate cancer. OncoImmunology 3(9), article number: e955331. (10.4161/21624011.2014.955331)
• Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13(4), pp. 1050-1064. (10.1074/mcp.M113.032136)

2013

• Webber, J. P. and Clayton, A. 2013. How pure are your vesicles?. Journal of Extracellular Vesicles 2, article number: 19861. (10.3402/jev.v2i0.19861)

2012

• Shah, K. M. et al. 2012. Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells [Letter]. Journal of Molecular Cell Biology 5(1), pp. 67-70. (10.1093/jmcb/mjs058)

2011

• Clayton, A., Al-Taei, S., Webber, J. P., Mason, M. D. and Tabi, Z. 2011. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. The Journal of Immunology 187(2), pp. 676-683. (10.4049/jimmunol.1003884)
• Michael, D. R. et al. 2011. The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell. Journal of Biological Chemistry 286(22), pp. 19523-19532. (10.1074/jbc.M111.233916)

2010

• Webber, J. P., Steadman, R., Mason, M. D., Tabi, Z. and Clayton, A. 2010. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Research 70(23), pp. 9621-9630. (10.1158/0008-5472.CAN-10-1722)

2009

• Zhang, L. et al. 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284(39), pp. 26447-26455. (10.1074/jbc.M109.003616)
• Webber, J. P., Jenkins, R. H., Meran, S., Phillips, A. O. and Steadman, R. 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175(1), pp. 148-160. (10.2353/ajpath.2009.080837)
• Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Hyaluronan orchestrates transforming growth factor-β1-dependent maintenance of myofibroblast phenotype. Journal of Biological Chemistry 284(14), pp. 9083-9092. (10.1074/jbc.M806989200)