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Dr Christopher Course
(Translated he/him)
BSc MBBCh
Cymrawd Ymchwil Clinigol
- CourseCW@caerdydd.ac.uk
- Prif Adeilad yr Ysbyty, Ystafell 6FT-164, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Trosolwyg
Graddiais o Ysgol Feddygaeth Univesrity Caerdydd yn 2011 ac yn ystod y cyfnod hwnnw cwblheais hefyd BSc rhyng-gyfrifedig mewn Pyscholeg a Meddygaeth. Ers graddio, dechreuais hyfforddiant pediatrig yn 2014, ac ar hyn o bryd rwyf ar y rhaglen hyfforddi is-arbenigedd ar gyfer neonatoleg a gynhelir gan y Coleg Brenhinol Pediatreg ac Iechyd Plant.
Ar hyn o bryd rwy'n cymryd tair blynedd i ffwrdd o waith clinigol i gwblhau PhD sy'n ymchwilio i gyfryngwyr biocemegol patholeg anadlol mewn goroeswyr oedran ysgol o enedigaeth gynamserol. Mae'r gwaith hwn yn canolbwyntio'n bennaf ar ddadansoddiad proteomig a metabolomig o samplau anadlol ac wrin a gymerwyd gan garfan fawr o blant a gymerodd ran yn astudiaeth RHiNO (Canlyniadau Iechyd Anadlol mewn Newyddonates). Rwyf hefyd yn aelod o'r tîm sy'n ymgymryd â dilyniant dwy flynedd ar gyfer babanod sydd wedi cofrestru ar dreial AZTEC (Azithromcyin ar gyfer Clefyd Cronig yr Ysgyfaint Cynaeddfed), sy'n archwilio'r defnydd o azithromycin cynnar i atal clefyd cronig yr ysgyfaint cynamserol.
Cyhoeddiad
2023
- Course, C. W. et al. 2023. Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia. Scientific Reports 13(1), article number: 19465. (10.1038/s41598-023-46499-w)
- Ratnaike, T., McDermott, H., McQuaid, F., Plumb, L., Wooding, E. L., Course, C. W. and Jackson, C. 2023. UK paediatric trainee research involvement: A national mixed-methods survey to highlight opportunities and challenges [Letter]. Archives of Disease in Childhood (10.1136/archdischild-2023-326401)
- Course, C. W. et al. 2023. Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children. Respiratory Research 24, article number: 191. (10.1186/s12931-023-02494-3)
- Gibbons, J. T., Course, C., Evans, E. E., Kotecha, S., Kotecha, S., Simpson, S. J. and Kotecha, S. 2023. Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis. ERJ Open Research 9(2), article number: 00046-2023. (10.1183/23120541.00046-2023)
- Course, C. W. et al. 2023. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports 13, article number: 7330. (10.1038/s41598-023-34233-5)
- Course, C. W., Kotecha, S. J., Cousins, M., Hart, K., Lowe, J., Watkins, W. J. and Kotecha, S. 2023. Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children. Journal of Pediatrics 255, pp. 42-49. (10.1016/j.jpeds.2022.09.057)
2022
- Kotecha, S. J., Gibbons, J. T. D., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Geographical differences and temporal improvements in forced expiratory volume in 1 second of preterm-born children. JAMA Pediatrics 176(9), pp. 867-877. (10.1001/jamapediatrics.2022.1990)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Kotecha, S., Gibbons, J., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Systematic review and meta-analysis of FEV1 in preterm born children. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1172., (10.1183/13993003.congress-2022.1172)
2021
- Edmondson, C., Course, C. W. and Doull, I. 2021. Cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis: a new dawn?. Archives of Disease in Childhood 106(10), pp. 941-945. (10.1136/archdischild-2020-320680)
- Course, C., Watkins, W. J., Müller, C. T., Odd, D., Kotecha, S. and Chakraborty, M. 2021. Volatile organic compounds as disease predictors in newborn infants: a systematic review. Journal of Breath Research 15(2), article number: 24002. (10.1088/1752-7163/abe283)
- Doull, I., Course, C. W., Hanks, R. E., Southern, K. W., Forton, J. T., Thia, L. P. and Moat, S. J. 2021. Cystic fibrosis newborn screening: the importance of bloodspot sample quality. Archives of Disease in Childhood 106(3), pp. 253-257. (10.1136/archdischild-2020-318999)
2020
- McDermott, H. et al. 2020. UK trainee-led paediatric governance collaboratives: improving the lives of both trainees and children. Archives of Disease in Childhood: Education & Practice 105(2), pp. 117-121. (10.1136/archdischild-2018-316354)
- Course, C. and Chakraborty, M. 2020. Management of respiratory distress syndrome in preterm infants In Wales: a full audit cycle of a quality improvement project. Scientific Reports 10, article number: 3536. (10.1038/s41598-020-60091-6)
2019
- Kotecha, S., Course, C. and Kotecha, S. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Presented at: European Respiratory Society International Congress 2018, Paris, France, 15-19 September 2018, Vol. 54. Vol. Supple. European Respiratory Society, (10.1183/13993003.congress-2019.PA1024)
- Course, C. and Hanks, R. 2019. Newborn screening for cystic fibrosis: Is there benefit for everyone?. Paediatric Respiratory Reviews 31, pp. 3-5. (10.1016/j.prrv.2019.02.003)
- Course, C. W., Kotecha, S. and Kotecha, S. J. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Pediatric Pulmonology 54(5), pp. 595-601. (10.1002/ppul.24270)
2017
- Ghani, S., Course, C. W. and Bodla, H. P. 2017. From sign to syndrome: Chilaiditi. Archives of Disease in Childhood 102(12), article number: 1117. (10.1136/archdischild-2017-313467)
- Course, C. W., Mott, A. and Tuthill, D. 2017. Surveying paediatricians' assessment of childhood bruising patterns. Archives of Disease in Childhood 102(12), pp. 1186-1187. (10.1136/archdischild-2017-313449)
- Course, C. W., Hanks, R. and Doull, I. 2017. Question 1 What is the best treatment option for empyema requiring drainage in children?. Archives of Disease in Childhood 102(6), pp. 588-590. (10.1136/archdischild-2017-312938)
Cynadleddau
- Kotecha, S., Gibbons, J., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Systematic review and meta-analysis of FEV1 in preterm born children. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1172., (10.1183/13993003.congress-2022.1172)
- Kotecha, S., Course, C. and Kotecha, S. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Presented at: European Respiratory Society International Congress 2018, Paris, France, 15-19 September 2018, Vol. 54. Vol. Supple. European Respiratory Society, (10.1183/13993003.congress-2019.PA1024)
Erthyglau
- Course, C. W. et al. 2023. Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia. Scientific Reports 13(1), article number: 19465. (10.1038/s41598-023-46499-w)
- Ratnaike, T., McDermott, H., McQuaid, F., Plumb, L., Wooding, E. L., Course, C. W. and Jackson, C. 2023. UK paediatric trainee research involvement: A national mixed-methods survey to highlight opportunities and challenges [Letter]. Archives of Disease in Childhood (10.1136/archdischild-2023-326401)
- Course, C. W. et al. 2023. Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children. Respiratory Research 24, article number: 191. (10.1186/s12931-023-02494-3)
- Gibbons, J. T., Course, C., Evans, E. E., Kotecha, S., Kotecha, S., Simpson, S. J. and Kotecha, S. 2023. Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis. ERJ Open Research 9(2), article number: 00046-2023. (10.1183/23120541.00046-2023)
- Course, C. W. et al. 2023. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports 13, article number: 7330. (10.1038/s41598-023-34233-5)
- Course, C. W., Kotecha, S. J., Cousins, M., Hart, K., Lowe, J., Watkins, W. J. and Kotecha, S. 2023. Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children. Journal of Pediatrics 255, pp. 42-49. (10.1016/j.jpeds.2022.09.057)
- Kotecha, S. J., Gibbons, J. T. D., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Geographical differences and temporal improvements in forced expiratory volume in 1 second of preterm-born children. JAMA Pediatrics 176(9), pp. 867-877. (10.1001/jamapediatrics.2022.1990)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Edmondson, C., Course, C. W. and Doull, I. 2021. Cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis: a new dawn?. Archives of Disease in Childhood 106(10), pp. 941-945. (10.1136/archdischild-2020-320680)
- Course, C., Watkins, W. J., Müller, C. T., Odd, D., Kotecha, S. and Chakraborty, M. 2021. Volatile organic compounds as disease predictors in newborn infants: a systematic review. Journal of Breath Research 15(2), article number: 24002. (10.1088/1752-7163/abe283)
- Doull, I., Course, C. W., Hanks, R. E., Southern, K. W., Forton, J. T., Thia, L. P. and Moat, S. J. 2021. Cystic fibrosis newborn screening: the importance of bloodspot sample quality. Archives of Disease in Childhood 106(3), pp. 253-257. (10.1136/archdischild-2020-318999)
- McDermott, H. et al. 2020. UK trainee-led paediatric governance collaboratives: improving the lives of both trainees and children. Archives of Disease in Childhood: Education & Practice 105(2), pp. 117-121. (10.1136/archdischild-2018-316354)
- Course, C. and Chakraborty, M. 2020. Management of respiratory distress syndrome in preterm infants In Wales: a full audit cycle of a quality improvement project. Scientific Reports 10, article number: 3536. (10.1038/s41598-020-60091-6)
- Course, C. and Hanks, R. 2019. Newborn screening for cystic fibrosis: Is there benefit for everyone?. Paediatric Respiratory Reviews 31, pp. 3-5. (10.1016/j.prrv.2019.02.003)
- Course, C. W., Kotecha, S. and Kotecha, S. J. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Pediatric Pulmonology 54(5), pp. 595-601. (10.1002/ppul.24270)
- Ghani, S., Course, C. W. and Bodla, H. P. 2017. From sign to syndrome: Chilaiditi. Archives of Disease in Childhood 102(12), article number: 1117. (10.1136/archdischild-2017-313467)
- Course, C. W., Mott, A. and Tuthill, D. 2017. Surveying paediatricians' assessment of childhood bruising patterns. Archives of Disease in Childhood 102(12), pp. 1186-1187. (10.1136/archdischild-2017-313449)
- Course, C. W., Hanks, R. and Doull, I. 2017. Question 1 What is the best treatment option for empyema requiring drainage in children?. Archives of Disease in Childhood 102(6), pp. 588-590. (10.1136/archdischild-2017-312938)
Ymchwil
Acocwnt geni cynamserol ar gyfer tua 10% o'r holl enedigaethau byw ac yn cynrychioli diddordeb iechyd sylweddol. Mae babanod sy'n cael eu geni'n eithriadol o gynamserol (beichiogrwydd <28 wythnos wedi'u cwblhau) mewn perygl uchel o farwolaeth gynnar a morbidrwydd tymor hwy, gyda symptomau cynyddol o ail-gysylltiol a phroblemau niwroddatblygiadol. Mae'r babanod hynny a anwyd yn llai cynamserol yn dal i fod â risg uwch o forbidrwydd tymor hwy.
Mae fy maes diddordeb yn ymwneud â'r canlyniadau resbiratroy tymor cynnar a hir ar gyfer babanod a anwyd yn gynamserol. Mae fy mhrosiect ymchwil presennol yn archwilio a oes newid biocemegol y gellir ei ganfod mewn plant oedran ysgol a anwyd yn gynamserol gyda llai o swyddogaeth yr ysgyfaint, o'i gymharu â'r plant hynny a aned cyn y tymor sydd â gwell swyddogaeth ysgyfaint a rheolaethau cyfatebol tymor. I wneud hyn, rwy'n ddata proteomic a metabolomig analsying a gymerir fel rhan o astudiaeth glinigol fawr (RHINO: Canlyniadau Iechyd Anadlol ar gyfer Newydd-onates). Mae'r gwaith hwn yn cael ei oruchwylio gan yr Athro Sailesh Kotecha, Dr Sarah Kotecha a Dr John Watkins.
Bywgraffiad
2021 - 2024: Cymrawd Ymchwil Clinigol/Myfyriwr PhD, Adran Iechyd Plant, Ysgol Meddygaeth, Prifysgol Caerdydd, UK
2019 - 2025: Hyfforddai Arbenigedd Newyddenedigol, Addysg a Gwella Iechyd Cymru, UK
2014 - 2019: Hyfforddai Arbenigedd Pediatrig, Addysg a Gwella Iechyd Cymru, y DU
2013 - 2014: Cymrawd Clinigol, Adran Neonatoleg, Ysbyty Athrofaol Cymru, Caerdydd, DU
2011 - 2013: Hyfforddai Rhaglen Sylfaen, Deoniaeth Cymru, UK
2005 - 2011: Israddedig, Ysgol Meddygaeth, Caerdydd, DU
Aelodaethau proffesiynol
- Aelod o'r Coleg Brenhinol Pediatreg ac Iechyd Plant
- British Associaiton of Perinatal Medicine
- Cymdeithas Resbiradol Pediatrig Prydain
Themâu ymchwil
Arbenigeddau
- Neonatoleg
- Afiechydon anadlol