![Christopher Course BSc MBBCh](https://profiles-cardiff.imgix.net/attachments/2408?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Christopher Course
(he/him)
BSc MBBCh
Clinical Research Fellow
- CourseCW@cardiff.ac.uk
- Main Hospital Building, Room 6FT-164, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Overview
I graduated from Cardiff Univesrity Medical School in 2011 during which time I also completed an intercalated BSc in Pyschology & Medicine. Since graduation, I entered paediatric training in 2014, and I am currently on the subspeciality training programme for neonatology run by the Royal College of Paediatrics and Child Health.
At present I am taking three years away from clinical work to complete a PhD investigating the biochemical mediators of respiratory pathology in school aged survivors of premature birth. This work is mainly focused on proteomic and metabolomic analysis of respiratory and urine samples taken from a large cohort of children who participated in the RHiNO (Respiratory Health Outcomes in Neonates) study. I am also a member of the team undertaking two-year follow up for infants enrolled on the AZTEC (Azithromcyin for Chronic Lung Disease of Prematurity) trial, which is examining the use of early azithromycin to prevent chronic lung disease of prematurity.
Publication
2023
- Course, C. W. et al. 2023. Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia. Scientific Reports 13(1), article number: 19465. (10.1038/s41598-023-46499-w)
- Ratnaike, T., McDermott, H., McQuaid, F., Plumb, L., Wooding, E. L., Course, C. W. and Jackson, C. 2023. UK paediatric trainee research involvement: A national mixed-methods survey to highlight opportunities and challenges [Letter]. Archives of Disease in Childhood (10.1136/archdischild-2023-326401)
- Course, C. W. et al. 2023. Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children. Respiratory Research 24, article number: 191. (10.1186/s12931-023-02494-3)
- Gibbons, J. T., Course, C., Evans, E. E., Kotecha, S., Kotecha, S., Simpson, S. J. and Kotecha, S. 2023. Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis. ERJ Open Research 9(2), article number: 00046-2023. (10.1183/23120541.00046-2023)
- Course, C. W. et al. 2023. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports 13, article number: 7330. (10.1038/s41598-023-34233-5)
- Course, C. W., Kotecha, S. J., Cousins, M., Hart, K., Lowe, J., Watkins, W. J. and Kotecha, S. 2023. Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children. Journal of Pediatrics 255, pp. 42-49. (10.1016/j.jpeds.2022.09.057)
2022
- Kotecha, S. J., Gibbons, J. T. D., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Geographical differences and temporal improvements in forced expiratory volume in 1 second of preterm-born children. JAMA Pediatrics 176(9), pp. 867-877. (10.1001/jamapediatrics.2022.1990)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Kotecha, S., Gibbons, J., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Systematic review and meta-analysis of FEV1 in preterm born children. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1172., (10.1183/13993003.congress-2022.1172)
2021
- Edmondson, C., Course, C. W. and Doull, I. 2021. Cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis: a new dawn?. Archives of Disease in Childhood 106(10), pp. 941-945. (10.1136/archdischild-2020-320680)
- Course, C., Watkins, W. J., Müller, C. T., Odd, D., Kotecha, S. and Chakraborty, M. 2021. Volatile organic compounds as disease predictors in newborn infants: a systematic review. Journal of Breath Research 15(2), article number: 24002. (10.1088/1752-7163/abe283)
- Doull, I., Course, C. W., Hanks, R. E., Southern, K. W., Forton, J. T., Thia, L. P. and Moat, S. J. 2021. Cystic fibrosis newborn screening: the importance of bloodspot sample quality. Archives of Disease in Childhood 106(3), pp. 253-257. (10.1136/archdischild-2020-318999)
2020
- McDermott, H. et al. 2020. UK trainee-led paediatric governance collaboratives: improving the lives of both trainees and children. Archives of Disease in Childhood: Education & Practice 105(2), pp. 117-121. (10.1136/archdischild-2018-316354)
- Course, C. and Chakraborty, M. 2020. Management of respiratory distress syndrome in preterm infants In Wales: a full audit cycle of a quality improvement project. Scientific Reports 10, article number: 3536. (10.1038/s41598-020-60091-6)
2019
- Kotecha, S., Course, C. and Kotecha, S. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Presented at: European Respiratory Society International Congress 2018, Paris, France, 15-19 September 2018, Vol. 54. Vol. Supple. European Respiratory Society, (10.1183/13993003.congress-2019.PA1024)
- Course, C. and Hanks, R. 2019. Newborn screening for cystic fibrosis: Is there benefit for everyone?. Paediatric Respiratory Reviews 31, pp. 3-5. (10.1016/j.prrv.2019.02.003)
- Course, C. W., Kotecha, S. and Kotecha, S. J. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Pediatric Pulmonology 54(5), pp. 595-601. (10.1002/ppul.24270)
2017
- Ghani, S., Course, C. W. and Bodla, H. P. 2017. From sign to syndrome: Chilaiditi. Archives of Disease in Childhood 102(12), article number: 1117. (10.1136/archdischild-2017-313467)
- Course, C. W., Mott, A. and Tuthill, D. 2017. Surveying paediatricians' assessment of childhood bruising patterns. Archives of Disease in Childhood 102(12), pp. 1186-1187. (10.1136/archdischild-2017-313449)
- Course, C. W., Hanks, R. and Doull, I. 2017. Question 1 What is the best treatment option for empyema requiring drainage in children?. Archives of Disease in Childhood 102(6), pp. 588-590. (10.1136/archdischild-2017-312938)
Articles
- Course, C. W. et al. 2023. Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia. Scientific Reports 13(1), article number: 19465. (10.1038/s41598-023-46499-w)
- Ratnaike, T., McDermott, H., McQuaid, F., Plumb, L., Wooding, E. L., Course, C. W. and Jackson, C. 2023. UK paediatric trainee research involvement: A national mixed-methods survey to highlight opportunities and challenges [Letter]. Archives of Disease in Childhood (10.1136/archdischild-2023-326401)
- Course, C. W. et al. 2023. Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children. Respiratory Research 24, article number: 191. (10.1186/s12931-023-02494-3)
- Gibbons, J. T., Course, C., Evans, E. E., Kotecha, S., Kotecha, S., Simpson, S. J. and Kotecha, S. 2023. Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis. ERJ Open Research 9(2), article number: 00046-2023. (10.1183/23120541.00046-2023)
- Course, C. W. et al. 2023. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports 13, article number: 7330. (10.1038/s41598-023-34233-5)
- Course, C. W., Kotecha, S. J., Cousins, M., Hart, K., Lowe, J., Watkins, W. J. and Kotecha, S. 2023. Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children. Journal of Pediatrics 255, pp. 42-49. (10.1016/j.jpeds.2022.09.057)
- Kotecha, S. J., Gibbons, J. T. D., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Geographical differences and temporal improvements in forced expiratory volume in 1 second of preterm-born children. JAMA Pediatrics 176(9), pp. 867-877. (10.1001/jamapediatrics.2022.1990)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Edmondson, C., Course, C. W. and Doull, I. 2021. Cystic fibrosis transmembrane conductance regulator modulators for cystic fibrosis: a new dawn?. Archives of Disease in Childhood 106(10), pp. 941-945. (10.1136/archdischild-2020-320680)
- Course, C., Watkins, W. J., Müller, C. T., Odd, D., Kotecha, S. and Chakraborty, M. 2021. Volatile organic compounds as disease predictors in newborn infants: a systematic review. Journal of Breath Research 15(2), article number: 24002. (10.1088/1752-7163/abe283)
- Doull, I., Course, C. W., Hanks, R. E., Southern, K. W., Forton, J. T., Thia, L. P. and Moat, S. J. 2021. Cystic fibrosis newborn screening: the importance of bloodspot sample quality. Archives of Disease in Childhood 106(3), pp. 253-257. (10.1136/archdischild-2020-318999)
- McDermott, H. et al. 2020. UK trainee-led paediatric governance collaboratives: improving the lives of both trainees and children. Archives of Disease in Childhood: Education & Practice 105(2), pp. 117-121. (10.1136/archdischild-2018-316354)
- Course, C. and Chakraborty, M. 2020. Management of respiratory distress syndrome in preterm infants In Wales: a full audit cycle of a quality improvement project. Scientific Reports 10, article number: 3536. (10.1038/s41598-020-60091-6)
- Course, C. and Hanks, R. 2019. Newborn screening for cystic fibrosis: Is there benefit for everyone?. Paediatric Respiratory Reviews 31, pp. 3-5. (10.1016/j.prrv.2019.02.003)
- Course, C. W., Kotecha, S. and Kotecha, S. J. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Pediatric Pulmonology 54(5), pp. 595-601. (10.1002/ppul.24270)
- Ghani, S., Course, C. W. and Bodla, H. P. 2017. From sign to syndrome: Chilaiditi. Archives of Disease in Childhood 102(12), article number: 1117. (10.1136/archdischild-2017-313467)
- Course, C. W., Mott, A. and Tuthill, D. 2017. Surveying paediatricians' assessment of childhood bruising patterns. Archives of Disease in Childhood 102(12), pp. 1186-1187. (10.1136/archdischild-2017-313449)
- Course, C. W., Hanks, R. and Doull, I. 2017. Question 1 What is the best treatment option for empyema requiring drainage in children?. Archives of Disease in Childhood 102(6), pp. 588-590. (10.1136/archdischild-2017-312938)
Conferences
- Kotecha, S., Gibbons, J., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Systematic review and meta-analysis of FEV1 in preterm born children. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1172., (10.1183/13993003.congress-2022.1172)
- Kotecha, S., Course, C. and Kotecha, S. 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Presented at: European Respiratory Society International Congress 2018, Paris, France, 15-19 September 2018, Vol. 54. Vol. Supple. European Respiratory Society, (10.1183/13993003.congress-2019.PA1024)
Research
Premature birth acocunts for approximately 10% of all live births and represents a substantial health interest. Infants born extremely prematurely (<28 weeks completed gestation) are at high risk for early mortality and longer term morbidity, with increased repsiratory symptoms and neurodevelopmental problems. Those infants born less premature still have an increased risk of longer term morbidity.
My area of interest relates to the early and long term respiratroy outcomes for infants born prematurely. My current research project is examining whether there is a detectable biochemical change in school age children born prematurely with reduced lung function, compared to those preterm born children with better lung function and term match controls. To undertake this I am analsying proteomic and metabolomic data taken as part of a large clinical study (RHINO: Respiratory Health Outcomes for Neonates). This work is being supervised by Professor Sailesh Kotecha, Dr Sarah Kotecha and Dr John Watkins.
Biography
2021 - 2024: Clinical Research Fellow/PhD Student, Department of Child Health, School of Medicine, Cardiff University, UK
2019 - 2025: Neonatalogy Speciality Trainee, Health Education and Improvement Wales, UK
2014 - 2019: Paediatric Speciality Trainee, Health Education and Improvement Wales, UK
2013 - 2014: Clinical Fellow, Department of Neonatology, University Hospital of Wales, Cardiff, UK
2011 - 2013: Foundation Programme Trainee, Wales Deanery, UK
2005 - 2011: Undergraduate, School of Medicine, Cardiff, UK
Professional memberships
- Member of the Royal College of Paediatrics and Child health
- British Associaiton of Perinatal Medicine
- British Paediatric Respiratory Society
Research themes
Specialisms
- Neonatology
- Respiratory diseases