Trosolwyg
Duncan Baird is a professor of Cancer and Genetics and is the sub-division lead for Genetic and Genome Medicine within the Division of Cancer and Genetics. His research group focuses on telomere biology and is funded by Cancer Research UK, the US NIH, Blood Cancer UK, Cancer Research Wales and Health and Care Research Wales
Cyhoeddiad
2025
- Pazhakh, V. et al. 2025. A novel TERT variant associated with a telomere biology disorder and challenges in variant classification. eJHaem 6(1), article number: e1066. (10.1002/jha2.1066)
2024
- Louise, C. et al. 2024. Letter to the Editor: Telomere length and DNA methylation epitype both provide independent prognostic information in CLL patients; data from the UK CLL, ARCTIC and ADMIRE clinical trials. British Journal of Haematology 205(5), pp. 2072-2076. (10.1111/bjh.19765)
- Baird, D. 2024. Telomere dynamics in human health and disease. Cold Spring Harbor Perspectives in Biology (10.1101/cshperspect.a041701)
2023
- Hulme, C. H. et al. 2023. The upscale manufacture of chondrocytes for allogeneic cartilage therapies. Tissue Engineering Part C Methods 29(9), pp. 424-437. (10.1089/ten.TEC.2023.0037)
- Roger, L., Miners, K. L., Leonard, L., Grimstead, J. W., Price, D. A., Baird, D. M. and Ladell, K. 2023. T cell memory revisited using single telomere length analysis. Frontiers in Immunology 14, article number: 1100535. (10.3389/fimmu.2023.1100535)
- Aquilanti, E. et al. 2023. Telomerase inhibition is an effective therapeutic strategy in TERT promoter mutant-glioblastoma models with low tumor volume. Neuro-Oncology 25(7), pp. 1275-1285. (10.1093/neuonc/noad024)
2022
- Liddiard, K., Aston-Evans, A. N., Cleal, K., Hendrickson, E. A. and Baird, D. M. 2022. POLQ suppresses genome instability and alterations in DNA repeat tract lengths. NAR Cancer 4(3), article number: zcac020. (10.1093/narcan/zcac020)
- Parker, C. et al. 2022. BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination. DNA Repair 115, article number: 103331. (10.1016/j.dnarep.2022.103331)
- Cleal, K. and Baird, D. 2022. Dysgu: efficient structural variant calling using short or long reads. Nucleic Acids Research 50(9), article number: e53. (10.1093/nar/gkac039)
- Pepper, A. G. S. et al. 2022. Combined analysis of IGHV mutations, telomere length and CD49d identifies long-term progression-free survivors in TP53 wild-type CLL treated with FCR-based therapies. Leukemia 36, pp. 271-274. (10.1038/s41375-021-01322-1)
- Geiller, H. E., Harvey, A., Jones, R. E., Grimstead, J. W., Cleal, K., Hendrickson, E. A. and Baird, D. 2022. ATRX modulates the escape from a telomere crisis. Plos Genetics 18(11), article number: e1010485. (10.1371/journal.pgen.1010485)
2021
- Garcia Martin, I., Penketh, R. J. A., Garay, S. M., Jones, R. E., Grimstead, J. W., Baird, D. M. and John, R. M. 2021. Symptoms of prenatal depression associated with shorter telomeres in female placenta. International Journal of Molecular Sciences 22(14), article number: 7458. (10.3390/ijms22147458)
- Norris, K. et al. 2021. High-throughput STELA provides a rapid test for the diagnosis of telomere biology disorders. Human Genetics 140, pp. 945-955. (10.1007/s00439-021-02257-4)
- Ngo, G. H. P., Grimstead, J. W. and Baird, D. M. 2021. UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair. Nature Communications 12, article number: 3849. (10.1038/s41467-021-24201-w)
- Liddiard, K., Grimstead, J., Cleal, K., Evans, A. and Baird, D. 2021. Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA Damage Response. NAR Cancer 3(1), article number: zcaa044. (10.1093/narcan/zcaa044)
- Ashworth, I. et al. 2021. Telomere length in Cystic Fibrosis patients - are patients with CF ageing too quickly?. International Journal of Aging Research 4, article number: 90. (10.28933/ijoar-2021-06-2005)
2020
- Galletti, G. et al. 2020. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nature Immunology 21, pp. 1552-1562. (10.1038/s41590-020-0791-5)
- Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
- Adishesh, M. et al. 2020. Human endometrial carcinogenesis is associated with significant reduction in long non-coding RNA, TERRA. International Journal of Molecular Sciences 21(22), article number: 8686. (10.3390/ijms21228686)
- Cleal, K. and Baird, D. 2020. Catastrophic endgames: emerging mechanisms of telomere-driven genomic instability. Trends in Genetics 36(5), pp. 347-359. (10.1016/j.tig.2020.02.001)
- Harrington, L. and Baird, D. 2020. Editorial overview: the instability of the cancer genome: it starts at the end. Current Opinion in Genetics and Development 60, pp. iii-vi. (10.1016/j.gde.2020.02.020)
- Kwok, M. et al. 2020. Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL. Blood 135(6), pp. 411-428. (10.1182/blood.2019001262)
2019
- Norris, K., Hillmen, P., Rawstron, A., Hills, R., Baird, D. M., Fegan, C. D. and Pepper, C. 2019. Telomere length predicts for outcome to FCR chemotherapy in CLL. Leukemia 33, pp. 1953-1963. (10.1038/s41375-019-0389-9)
- Escudero, L., Cleal, K., Ashelford, K., Fegan, C., Pepper, C., Liddiard, K. and Baird, D. M. 2019. Telomere fusions associate with coding sequence and copy number alterations in CLL. Leukemia 33, pp. 2093-2097. (10.1038/s41375-019-0423-y)
- Cleal, K., Jones, R. E., Grimstead, J. W., Hendrickson, E. A. and Baird, D. M. 2019. Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin. Genome Research 29(5), pp. 737-749. (10.1101/gr.240705.118)
- Liddiard, K., Ruis, B., Kan, Y., Cleal, K., Ashelford, K. E., Hendrickson, E. A. and Baird, D. M. 2019. DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase. Nucleic Acids Research 47(5), pp. 2402-2424. (10.1093/nar/gky1279)
- Mansell, E. et al. 2019. DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation. Scientific Reports 9, article number: 4370. (10.1038/s41598-019-39552-0)
- Pringle, S. et al. 2019. Salivary gland stem cells age prematurely in primary Sjögren's syndrome. Arthritis & Rheumatology 71(1), pp. 133-142. (10.1002/art.40659)
2018
- Ngo, G., Hyatt, S., Grimstead, J., Jones, R., Hendrickson, E., Pepper, C. and Baird, D. 2018. PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation. Oncotarget 9(101), pp. 37549-37563. (10.18632/oncotarget.26499)
- Garcia-Martin, I., Penketh, R., Janssen, A. B., Jones, R. E., Grimstead, J., Baird, D. and John, R. 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13(12), article number: : e0208533. (10.1371/journal.pone.0208533)
- Harvey, A. et al. 2018. PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ. Oncotarget 9(78), pp. 34821-34837. (10.18632/oncotarget.26201)
- Baird, D. M. and Hendrickson, E. A. 2018. Telomeres and Chromosomal Translocations. Advances in Experimental Medicine and Biology 1044, pp. 89-112. (10.1007/978-981-13-0593-1_7)
- Costa del Amo, P. et al. 2018. Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness. PLoS Biology 16(6), article number: e2005523. (10.1371/journal.pbio.2005523)
- Nelson, N. D. et al. 2018. The C-terminal extension unique to the long isoform of the shelterin component TIN2 enhances its interaction with TRF2 in a phosphorylation- and dyskeratosis congenita-cluster-dependent fashion. Molecular and Cellular Biology 38(12), article number: e00025-18. (10.1128/MCB.00025-18)
- Baird, D. M. 2018. Telomeres and genomic evolution. Philosophical Transactions B: Biological Sciences 373(1741), article number: 20160437. (10.1098/rstb.2016.0437)
- McCully, M. L. et al. 2018. CCR8 expression defines tissue-resident memory T cells in human skin. Journal of Immunology 200(5), pp. 1639-1650. (10.4049/jimmunol.1701377)
- Pilsworth, J. A. et al. 2018. TERT promoter mutation in adult granulosa cell tumor of the ovary. Modern Pathology 31, pp. 1107-1115. (10.1038/s41379-018-0007-9)
- Cleal, K., Norris, K. and Baird, D. 2018. Telomere length dynamics and the evolution of cancer genome architecture. International Journal of Molecular Sciences 19(2), pp. 482-482. (10.3390/ijms19020482)
2017
- Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
- Hyatt, S. et al. 2017. Telomere length is a critical determinant for survival in multiple myeloma. British Journal of Haematology 178(1), pp. 94-98. (10.1111/bjh.14643)
- Williams, J. et al. 2017. Telomere length is an independent prognostic marker in MDS but not in de novo AML. British Journal of Haematology 178(2), pp. 240-249.
- Lopez Anton, M. et al. 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164, pp. 37-40. (10.1016/j.mad.2017.03.010)
- Rice, C. et al. 2017. Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nature Communications 8, article number: 14928. (10.1038/ncomms14928)
- Robinson, R., Grimstead, J., Sedani, A., Baird, D. and Upadhyaya, M. 2017. Telomere erosion in NF1 tumorigenesis. Oncotarget 8(25), pp. 40132-40139. (10.18632/oncotarget.16981)
- Letsolo, B., Robinson, R., Rowson, J., Grimstead, J., Keith, N., Jenkins, G. and Baird, D. M. 2017. Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia. Plos One 12(3), article number: e0174833.
- Fellows, C. R. et al. 2017. Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence. Scientific Reports 7, article number: 41421. (10.1038/srep41421)
2016
- Ahmed, R. et al. 2016. Human stem cell-like memory T cells are maintained in a state of dynamic flux. Cell Reports 17(11), pp. 2811-2818. (10.1016/j.celrep.2016.11.037)
- Nelson, D. M. et al. 2016. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biology 17, article number: 158. (10.1186/s13059-016-1017-x)
- Liddiard, K., Ruis, B., Takasugi, T., Harvey, A., Ashelford, K. E., Hendrickson, E. A. and Baird, D. M. 2016. Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4. Genome Research 26, pp. 588-600. (10.1101/gr.200840.115)
2015
- Strefford, J. C. et al. 2015. Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial. Leukemia 29(12), pp. 2411-2414. (10.1038/leu.2015.217)
- Martin-Ruiz, C. M. et al. 2015. Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology 44(5), pp. 1673-1683. (10.1093/ije/dyu191)
- Martin-Ruiz, C. M. et al. 2015. Reproducibility of telomere length assessment: Authors’ response to Damjan Krstajic and Ljubomir Buturovic. International Journal of Epidemiology 44(5), pp. 1739-1741. (10.1093/ije/dyv170)
- Martin-Ruiz, C. M. et al. 2015. Is Southern blotting necessary to measure telomere length reproducibly? Authors? Response to: Commentary: The reliability of telomere length measurements. International Journal of Epidemiology 44(5), pp. 1686-1687. (10.1093/ije/dyv169)
- Simpson, K., Jones, R. E., Grimstead, J. W., Hills, R. K., Pepper, C. J. and Baird, D. M. 2015. Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients. Molecular Oncology 9(6), pp. 1186-1193. (10.1016/j.molonc.2015.02.003)
2014
- Lin, T. T. et al. 2014. Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. British Journal of Haematology 167(2), pp. 214-223. (10.1111/bjh.13023)
- Jones, R. E. et al. 2014. Escape from telomere-driven crisis is DNA Ligase III dependent. Cell Reports 8(4), pp. 1063-1076. (10.1016/j.celrep.2014.07.007)
- Nussey, D. H. et al. 2014. Measuring telomere length and telomere dynamics in evolutionary biology and ecology. Methods in Ecology and Evolution 5(4), pp. 299-310. (10.1111/2041-210X.12161)
- Pepper, C. J., Baird, D. M. and Fegan, C. D. 2014. Telomere analysis to predict chronic lymphocytic leukemia outcome: a STELA test to change clinical practice?. Expert Review of Hematology 7(6), pp. 701-703. (10.1586/17474086.2014.969705)
2013
- Singh, U., Maturi, V., Jones, R., Paulsson, Y., Baird, D. . M. and Westermark, B. 2013. CGGBP1 phosphorylation constitutes a telomere-protection signal. Cell Cycle 13(1), pp. 96-105. (10.4161/cc.26813)
- Roger, L., Jones, R. E., Heppel, N., Williams, G. T., Sampson, J. R. and Baird, D. M. 2013. Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. Journal of the National Cancer Institute 105(16), pp. 1202-1211. (10.1093/jnci/djt191)
2012
- Pettigrew, K. A. et al. 2012. Differential tert promoter methylation and response to 5-aza-20-deoxycytidine in Acute Myeloid Leukemia cell lines: tert expression, telomerase activity, telomere length, and cell death. Genes, Chromosomes and Cancer 51(8), pp. 768-780. (10.1002/gcc.21962)
- Britt-Compton, B. et al. 2012. Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage [Letter]. Leukemia 26(4), pp. 826-830. (10.1038/leu.2011.281)
- Mocellin, S. et al. 2012. Telomerase reverse transcriptase locus polymorphisms and cancer risk: A field synopsis and meta-analysis. Journal of the National Cancer Institute 104(11), pp. 840-854. (10.1093/jnci/djs222)
- Tankimanova, M. et al. 2012. Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Research 40(6), pp. 2518-2526. (10.1093/nar/gkr1117)
- Jones, C. H., Pepper, C. J. and Baird, D. M. 2012. Telomere dysfunction and its role in haematological cancer. British Journal of Haematology 156(5), pp. 573-587. (10.1111/j.1365-2141.2011.09022.x)
2011
- Sood, A. et al. 2011. Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nature Nanotechnology 6(12), pp. 824-833. (10.1038/nnano.2011.188)
- Svenson, U., Nordfjäll, K., Baird, D. M., Roger, L., Osterman, P., Hellenius, M. and Roos, G. 2011. Blood cell telomere length is a dynamic feature. PLoS ONE 6(6), article number: e21485. (10.1371/journal.pone.0021485)
2010
- Pepper, C. J. and Baird, D. M. 2010. Shortened telomeres: a driving force behind leukemia? [Editorial]. Future Oncology 6(11), pp. 1681-1686. (10.2217/fon.10.135)
- Takubo, K. et al. 2010. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mechanisms of Ageing and Development 131(10), pp. 614-624. (10.1016/j.mad.2010.08.007)
- Williams, R. et al. 2010. Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. PLoS ONE 5(10), article number: e13246. (10.1371/journal.pone.0013246)
- Lin, T. T. et al. 2010. Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood 116(11), pp. 1899-1907. (10.1182/blood-2010-02-272104)
- Letsolo, B. T., Rowson, J. M. and Baird, D. M. 2010. Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Research 38(6), pp. 1841-1852. (10.1093/nar/gkp1183)
- Cogan, N. et al. 2010. DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 683(1-2), pp. 1-8. (10.1016/j.mrfmmm.2009.09.012)
2009
- Britt-Compton, B., Wyllie, F. S., Rowson, J. M., Capper, R., Jones, R. E. and Baird, D. M. 2009. Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells. Biogerontology 10(6), pp. 683-693. (10.1007/s10522-009-9216-4)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Roberts, G. W., Baird, D. M., Gallagher, K. M. E., Robinson, R. E., Pepper, C. J., Williams, J. D. and Topley, N. 2009. Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis. Journal of the American Society of Nephrology 20(9), pp. 1895-1900. (10.1681/ASN.2008101127)
- Allen, N. D. and Baird, D. M. 2009. Telomere length maintenance in stem cell populations. Biochimica et Biophysica Acta-Molecular Basis of Disease 1792(4), pp. 324-328. (10.1016/j.bbadis.2009.02.004)
- Britt-Compton, B., Capper, R., Rowson, J. and Baird, D. M. 2009. Short telomeres are preferentially elongated by telomerase in human cells. FEBS Letters 583(18), pp. 3076-3080. (10.1016/j.febslet.2009.08.029)
- Williams, R. et al. 2009. A sub-population of human articular cartilage cells display stem cell/progenitor characteristics. European Cells and Materials 18(Supp 1), pp. 65.
2008
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Lin, T. T. et al. 2008. Highly purified CD38+ sub-populations show no evidence of preferential clonal evolution despite having increased proliferative activity when compared with CD38+ sub-populations derived from the same chronic lymphocytic leukaemia patient. British Journal of Haematology 142(4), pp. 595-605. (10.1111/j.1365-2141.2008.07236.x)
- Baird, D. M. 2008. Telomere dynamics in human cells. Biochimie 90(1), pp. 116-121. (10.1016/j.biochi.2007.08.003)
2007
- Capper, R. et al. 2007. The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes and Development 21(19), pp. 2495-2508. (10.1101/gad.439107)
- Papageorgiou, I. et al. 2007. Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 619(1-2), pp. 45-58. (10.1016/j.mrfmmm.2007.01.008)
- Baird, D. M. 2007. Telomeres II. Experimental Gerontology 43(1), pp. 15-19. (10.1016/j.exger.2007.10.002)
- Baird, D. M. 2007. Telomeres. In: Marshall, V. et al. eds. Encyclopaedia of Gerontology (2nd ed.). Amsterdam: Elsevier, pp. 593-601., (10.1016/B0-12-370870-2/00185-2)
2006
- Baird, D. M. 2006. Telomeres. Experimental Gerontology 41(12), pp. 1223-1227. (10.1016/j.exger.2006.09.009)
- Britt-Compton, B., Rowson, J. M., Locke, M., Mackenzie, I., Kipling, D. G. and Baird, D. M. 2006. Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Human Molecular Genetics 15(5), pp. 725-733. (10.1093/hmg/ddi486)
- Baird, D. M., Britt-Compton, B., Rowson, J. M., Amso, N. N., Gregory, L. and Kipling, D. G. 2006. Telomere instability in the male germline. Human molecular genetics 15(1), pp. 45-51. (10.1093/hmg/ddi424)
- Britt-Compton, B. and Baird, D. M. 2006. Intra-allelic mutation at human telomeres. Biochemical Society Transactions 34(4), pp. 581-582. (10.1042/BST0340581)
- Glaviano, A. et al. 2006. Effects of hTERT on metal ion-induced genomic instability. Oncogene 25(24), pp. 3424-3435. (10.1038/sj.onc.1209399)
- Baird, D. M. and Farr, C. J. 2006. The organization and function of chromosomes [Meeting Report]. EMBO Reports 7(4), pp. 372-376. (10.1038/sj.embor.7400661)
2005
- Davis, T., Baird, D. M., Haughton, M. F., Jones, C. J. and Kipling, D. G. 2005. Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 60(11), pp. 1386-93.
- Baird, D. M. 2005. New developments in telomere length analysis. Experimental Gerontology 40(5), pp. 363-368. (10.1016/j.exger.2005.02.008)
2004
- Baird, D. M., Davis, T., Rowson, J. M., Jones, C. J. and Kipling, D. G. 2004. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Human Molecular Genetics 13(14), pp. 1515-1524. (10.1093/hmg/ddh159)
- Baird, D. M. and Kipling, D. G. 2004. The extent and significance of telomere loss with age. Annals of the New York Academy of Sciences 1019(1), pp. 265-268. (10.1196/annals.1297.044)
- Pickett, H. A. et al. 2004. Telomere instability detected in sporadic colon cancers, some showing mutations in a mismatch repair gene. Oncogene 23(19), pp. 3434-3443. (10.1038/sj.onc.1207477)
- Cheung, I., Schertzer, M., Baross, A., Rose, A. M., Lansdorp, P. M. and Baird, D. M. 2004. Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Research 32(11), pp. 3383-3391. (10.1093/nar/gkh661)
2003
- Baird, D. M., Rowson, J. M., Wynford-Thomas, D. and Kipling, D. G. 2003. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nature Genetics 33(2), pp. 203-207. (10.1038/ng1084)
2000
- Baird, D. M., Coleman, J., Rosser, Z. and Royle, N. 2000. High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution. American Journal of Human Genetics 66(1), pp. 235-250. (10.1086/302721)
1999
- Coleman, J., Baird, D. M. and Royle, N. J. 1999. The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q. Human Molecular Genetics 8(9), pp. 1637-1646. (10.1093/hmg/8.9.1637)
1997
- Baird, D. M. and Royle, N. J. 1997. Sequences from higher primates orthologous to the human Xp/Yp telomere junction region reveal gross rearrangements and high levels of divergence. Human Molecular Genetics 6(13), pp. 2291-2299. (10.1093/hmg/6.13.2291)
1995
- Baird, D. M., Jeffreys, A. J. and Royle, N. J. 1995. Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. EMBO Journal 14(21), pp. 5433-5443.
1994
- Royle, N. J., Baird, D. M. and Jeffreys, A. J. 1994. A subterminal satellite located adjacent to telomeres in chimpanzees is absent from the human genome. Nature Genetics 6(1), pp. 52-56. (10.1038/ng0194-52)
Articles
- Pazhakh, V. et al. 2025. A novel TERT variant associated with a telomere biology disorder and challenges in variant classification. eJHaem 6(1), article number: e1066. (10.1002/jha2.1066)
- Louise, C. et al. 2024. Letter to the Editor: Telomere length and DNA methylation epitype both provide independent prognostic information in CLL patients; data from the UK CLL, ARCTIC and ADMIRE clinical trials. British Journal of Haematology 205(5), pp. 2072-2076. (10.1111/bjh.19765)
- Baird, D. 2024. Telomere dynamics in human health and disease. Cold Spring Harbor Perspectives in Biology (10.1101/cshperspect.a041701)
- Hulme, C. H. et al. 2023. The upscale manufacture of chondrocytes for allogeneic cartilage therapies. Tissue Engineering Part C Methods 29(9), pp. 424-437. (10.1089/ten.TEC.2023.0037)
- Roger, L., Miners, K. L., Leonard, L., Grimstead, J. W., Price, D. A., Baird, D. M. and Ladell, K. 2023. T cell memory revisited using single telomere length analysis. Frontiers in Immunology 14, article number: 1100535. (10.3389/fimmu.2023.1100535)
- Aquilanti, E. et al. 2023. Telomerase inhibition is an effective therapeutic strategy in TERT promoter mutant-glioblastoma models with low tumor volume. Neuro-Oncology 25(7), pp. 1275-1285. (10.1093/neuonc/noad024)
- Liddiard, K., Aston-Evans, A. N., Cleal, K., Hendrickson, E. A. and Baird, D. M. 2022. POLQ suppresses genome instability and alterations in DNA repeat tract lengths. NAR Cancer 4(3), article number: zcac020. (10.1093/narcan/zcac020)
- Parker, C. et al. 2022. BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination. DNA Repair 115, article number: 103331. (10.1016/j.dnarep.2022.103331)
- Cleal, K. and Baird, D. 2022. Dysgu: efficient structural variant calling using short or long reads. Nucleic Acids Research 50(9), article number: e53. (10.1093/nar/gkac039)
- Pepper, A. G. S. et al. 2022. Combined analysis of IGHV mutations, telomere length and CD49d identifies long-term progression-free survivors in TP53 wild-type CLL treated with FCR-based therapies. Leukemia 36, pp. 271-274. (10.1038/s41375-021-01322-1)
- Geiller, H. E., Harvey, A., Jones, R. E., Grimstead, J. W., Cleal, K., Hendrickson, E. A. and Baird, D. 2022. ATRX modulates the escape from a telomere crisis. Plos Genetics 18(11), article number: e1010485. (10.1371/journal.pgen.1010485)
- Garcia Martin, I., Penketh, R. J. A., Garay, S. M., Jones, R. E., Grimstead, J. W., Baird, D. M. and John, R. M. 2021. Symptoms of prenatal depression associated with shorter telomeres in female placenta. International Journal of Molecular Sciences 22(14), article number: 7458. (10.3390/ijms22147458)
- Norris, K. et al. 2021. High-throughput STELA provides a rapid test for the diagnosis of telomere biology disorders. Human Genetics 140, pp. 945-955. (10.1007/s00439-021-02257-4)
- Ngo, G. H. P., Grimstead, J. W. and Baird, D. M. 2021. UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair. Nature Communications 12, article number: 3849. (10.1038/s41467-021-24201-w)
- Liddiard, K., Grimstead, J., Cleal, K., Evans, A. and Baird, D. 2021. Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA Damage Response. NAR Cancer 3(1), article number: zcaa044. (10.1093/narcan/zcaa044)
- Ashworth, I. et al. 2021. Telomere length in Cystic Fibrosis patients - are patients with CF ageing too quickly?. International Journal of Aging Research 4, article number: 90. (10.28933/ijoar-2021-06-2005)
- Galletti, G. et al. 2020. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nature Immunology 21, pp. 1552-1562. (10.1038/s41590-020-0791-5)
- Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
- Adishesh, M. et al. 2020. Human endometrial carcinogenesis is associated with significant reduction in long non-coding RNA, TERRA. International Journal of Molecular Sciences 21(22), article number: 8686. (10.3390/ijms21228686)
- Cleal, K. and Baird, D. 2020. Catastrophic endgames: emerging mechanisms of telomere-driven genomic instability. Trends in Genetics 36(5), pp. 347-359. (10.1016/j.tig.2020.02.001)
- Harrington, L. and Baird, D. 2020. Editorial overview: the instability of the cancer genome: it starts at the end. Current Opinion in Genetics and Development 60, pp. iii-vi. (10.1016/j.gde.2020.02.020)
- Kwok, M. et al. 2020. Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL. Blood 135(6), pp. 411-428. (10.1182/blood.2019001262)
- Norris, K., Hillmen, P., Rawstron, A., Hills, R., Baird, D. M., Fegan, C. D. and Pepper, C. 2019. Telomere length predicts for outcome to FCR chemotherapy in CLL. Leukemia 33, pp. 1953-1963. (10.1038/s41375-019-0389-9)
- Escudero, L., Cleal, K., Ashelford, K., Fegan, C., Pepper, C., Liddiard, K. and Baird, D. M. 2019. Telomere fusions associate with coding sequence and copy number alterations in CLL. Leukemia 33, pp. 2093-2097. (10.1038/s41375-019-0423-y)
- Cleal, K., Jones, R. E., Grimstead, J. W., Hendrickson, E. A. and Baird, D. M. 2019. Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin. Genome Research 29(5), pp. 737-749. (10.1101/gr.240705.118)
- Liddiard, K., Ruis, B., Kan, Y., Cleal, K., Ashelford, K. E., Hendrickson, E. A. and Baird, D. M. 2019. DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase. Nucleic Acids Research 47(5), pp. 2402-2424. (10.1093/nar/gky1279)
- Mansell, E. et al. 2019. DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation. Scientific Reports 9, article number: 4370. (10.1038/s41598-019-39552-0)
- Pringle, S. et al. 2019. Salivary gland stem cells age prematurely in primary Sjögren's syndrome. Arthritis & Rheumatology 71(1), pp. 133-142. (10.1002/art.40659)
- Ngo, G., Hyatt, S., Grimstead, J., Jones, R., Hendrickson, E., Pepper, C. and Baird, D. 2018. PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation. Oncotarget 9(101), pp. 37549-37563. (10.18632/oncotarget.26499)
- Garcia-Martin, I., Penketh, R., Janssen, A. B., Jones, R. E., Grimstead, J., Baird, D. and John, R. 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13(12), article number: : e0208533. (10.1371/journal.pone.0208533)
- Harvey, A. et al. 2018. PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ. Oncotarget 9(78), pp. 34821-34837. (10.18632/oncotarget.26201)
- Baird, D. M. and Hendrickson, E. A. 2018. Telomeres and Chromosomal Translocations. Advances in Experimental Medicine and Biology 1044, pp. 89-112. (10.1007/978-981-13-0593-1_7)
- Costa del Amo, P. et al. 2018. Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness. PLoS Biology 16(6), article number: e2005523. (10.1371/journal.pbio.2005523)
- Nelson, N. D. et al. 2018. The C-terminal extension unique to the long isoform of the shelterin component TIN2 enhances its interaction with TRF2 in a phosphorylation- and dyskeratosis congenita-cluster-dependent fashion. Molecular and Cellular Biology 38(12), article number: e00025-18. (10.1128/MCB.00025-18)
- Baird, D. M. 2018. Telomeres and genomic evolution. Philosophical Transactions B: Biological Sciences 373(1741), article number: 20160437. (10.1098/rstb.2016.0437)
- McCully, M. L. et al. 2018. CCR8 expression defines tissue-resident memory T cells in human skin. Journal of Immunology 200(5), pp. 1639-1650. (10.4049/jimmunol.1701377)
- Pilsworth, J. A. et al. 2018. TERT promoter mutation in adult granulosa cell tumor of the ovary. Modern Pathology 31, pp. 1107-1115. (10.1038/s41379-018-0007-9)
- Cleal, K., Norris, K. and Baird, D. 2018. Telomere length dynamics and the evolution of cancer genome architecture. International Journal of Molecular Sciences 19(2), pp. 482-482. (10.3390/ijms19020482)
- Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
- Hyatt, S. et al. 2017. Telomere length is a critical determinant for survival in multiple myeloma. British Journal of Haematology 178(1), pp. 94-98. (10.1111/bjh.14643)
- Williams, J. et al. 2017. Telomere length is an independent prognostic marker in MDS but not in de novo AML. British Journal of Haematology 178(2), pp. 240-249.
- Lopez Anton, M. et al. 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164, pp. 37-40. (10.1016/j.mad.2017.03.010)
- Rice, C. et al. 2017. Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nature Communications 8, article number: 14928. (10.1038/ncomms14928)
- Robinson, R., Grimstead, J., Sedani, A., Baird, D. and Upadhyaya, M. 2017. Telomere erosion in NF1 tumorigenesis. Oncotarget 8(25), pp. 40132-40139. (10.18632/oncotarget.16981)
- Letsolo, B., Robinson, R., Rowson, J., Grimstead, J., Keith, N., Jenkins, G. and Baird, D. M. 2017. Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia. Plos One 12(3), article number: e0174833.
- Fellows, C. R. et al. 2017. Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence. Scientific Reports 7, article number: 41421. (10.1038/srep41421)
- Ahmed, R. et al. 2016. Human stem cell-like memory T cells are maintained in a state of dynamic flux. Cell Reports 17(11), pp. 2811-2818. (10.1016/j.celrep.2016.11.037)
- Nelson, D. M. et al. 2016. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biology 17, article number: 158. (10.1186/s13059-016-1017-x)
- Liddiard, K., Ruis, B., Takasugi, T., Harvey, A., Ashelford, K. E., Hendrickson, E. A. and Baird, D. M. 2016. Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4. Genome Research 26, pp. 588-600. (10.1101/gr.200840.115)
- Strefford, J. C. et al. 2015. Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial. Leukemia 29(12), pp. 2411-2414. (10.1038/leu.2015.217)
- Martin-Ruiz, C. M. et al. 2015. Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology 44(5), pp. 1673-1683. (10.1093/ije/dyu191)
- Martin-Ruiz, C. M. et al. 2015. Reproducibility of telomere length assessment: Authors’ response to Damjan Krstajic and Ljubomir Buturovic. International Journal of Epidemiology 44(5), pp. 1739-1741. (10.1093/ije/dyv170)
- Martin-Ruiz, C. M. et al. 2015. Is Southern blotting necessary to measure telomere length reproducibly? Authors? Response to: Commentary: The reliability of telomere length measurements. International Journal of Epidemiology 44(5), pp. 1686-1687. (10.1093/ije/dyv169)
- Simpson, K., Jones, R. E., Grimstead, J. W., Hills, R. K., Pepper, C. J. and Baird, D. M. 2015. Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients. Molecular Oncology 9(6), pp. 1186-1193. (10.1016/j.molonc.2015.02.003)
- Lin, T. T. et al. 2014. Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. British Journal of Haematology 167(2), pp. 214-223. (10.1111/bjh.13023)
- Jones, R. E. et al. 2014. Escape from telomere-driven crisis is DNA Ligase III dependent. Cell Reports 8(4), pp. 1063-1076. (10.1016/j.celrep.2014.07.007)
- Nussey, D. H. et al. 2014. Measuring telomere length and telomere dynamics in evolutionary biology and ecology. Methods in Ecology and Evolution 5(4), pp. 299-310. (10.1111/2041-210X.12161)
- Pepper, C. J., Baird, D. M. and Fegan, C. D. 2014. Telomere analysis to predict chronic lymphocytic leukemia outcome: a STELA test to change clinical practice?. Expert Review of Hematology 7(6), pp. 701-703. (10.1586/17474086.2014.969705)
- Singh, U., Maturi, V., Jones, R., Paulsson, Y., Baird, D. . M. and Westermark, B. 2013. CGGBP1 phosphorylation constitutes a telomere-protection signal. Cell Cycle 13(1), pp. 96-105. (10.4161/cc.26813)
- Roger, L., Jones, R. E., Heppel, N., Williams, G. T., Sampson, J. R. and Baird, D. M. 2013. Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. Journal of the National Cancer Institute 105(16), pp. 1202-1211. (10.1093/jnci/djt191)
- Pettigrew, K. A. et al. 2012. Differential tert promoter methylation and response to 5-aza-20-deoxycytidine in Acute Myeloid Leukemia cell lines: tert expression, telomerase activity, telomere length, and cell death. Genes, Chromosomes and Cancer 51(8), pp. 768-780. (10.1002/gcc.21962)
- Britt-Compton, B. et al. 2012. Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage [Letter]. Leukemia 26(4), pp. 826-830. (10.1038/leu.2011.281)
- Mocellin, S. et al. 2012. Telomerase reverse transcriptase locus polymorphisms and cancer risk: A field synopsis and meta-analysis. Journal of the National Cancer Institute 104(11), pp. 840-854. (10.1093/jnci/djs222)
- Tankimanova, M. et al. 2012. Mre11 modulates the fidelity of fusion between short telomeres in human cells. Nucleic Acids Research 40(6), pp. 2518-2526. (10.1093/nar/gkr1117)
- Jones, C. H., Pepper, C. J. and Baird, D. M. 2012. Telomere dysfunction and its role in haematological cancer. British Journal of Haematology 156(5), pp. 573-587. (10.1111/j.1365-2141.2011.09022.x)
- Sood, A. et al. 2011. Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nature Nanotechnology 6(12), pp. 824-833. (10.1038/nnano.2011.188)
- Svenson, U., Nordfjäll, K., Baird, D. M., Roger, L., Osterman, P., Hellenius, M. and Roos, G. 2011. Blood cell telomere length is a dynamic feature. PLoS ONE 6(6), article number: e21485. (10.1371/journal.pone.0021485)
- Pepper, C. J. and Baird, D. M. 2010. Shortened telomeres: a driving force behind leukemia? [Editorial]. Future Oncology 6(11), pp. 1681-1686. (10.2217/fon.10.135)
- Takubo, K. et al. 2010. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mechanisms of Ageing and Development 131(10), pp. 614-624. (10.1016/j.mad.2010.08.007)
- Williams, R. et al. 2010. Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. PLoS ONE 5(10), article number: e13246. (10.1371/journal.pone.0013246)
- Lin, T. T. et al. 2010. Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood 116(11), pp. 1899-1907. (10.1182/blood-2010-02-272104)
- Letsolo, B. T., Rowson, J. M. and Baird, D. M. 2010. Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Research 38(6), pp. 1841-1852. (10.1093/nar/gkp1183)
- Cogan, N. et al. 2010. DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 683(1-2), pp. 1-8. (10.1016/j.mrfmmm.2009.09.012)
- Britt-Compton, B., Wyllie, F. S., Rowson, J. M., Capper, R., Jones, R. E. and Baird, D. M. 2009. Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells. Biogerontology 10(6), pp. 683-693. (10.1007/s10522-009-9216-4)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Roberts, G. W., Baird, D. M., Gallagher, K. M. E., Robinson, R. E., Pepper, C. J., Williams, J. D. and Topley, N. 2009. Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis. Journal of the American Society of Nephrology 20(9), pp. 1895-1900. (10.1681/ASN.2008101127)
- Allen, N. D. and Baird, D. M. 2009. Telomere length maintenance in stem cell populations. Biochimica et Biophysica Acta-Molecular Basis of Disease 1792(4), pp. 324-328. (10.1016/j.bbadis.2009.02.004)
- Britt-Compton, B., Capper, R., Rowson, J. and Baird, D. M. 2009. Short telomeres are preferentially elongated by telomerase in human cells. FEBS Letters 583(18), pp. 3076-3080. (10.1016/j.febslet.2009.08.029)
- Williams, R. et al. 2009. A sub-population of human articular cartilage cells display stem cell/progenitor characteristics. European Cells and Materials 18(Supp 1), pp. 65.
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Lin, T. T. et al. 2008. Highly purified CD38+ sub-populations show no evidence of preferential clonal evolution despite having increased proliferative activity when compared with CD38+ sub-populations derived from the same chronic lymphocytic leukaemia patient. British Journal of Haematology 142(4), pp. 595-605. (10.1111/j.1365-2141.2008.07236.x)
- Baird, D. M. 2008. Telomere dynamics in human cells. Biochimie 90(1), pp. 116-121. (10.1016/j.biochi.2007.08.003)
- Capper, R. et al. 2007. The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes and Development 21(19), pp. 2495-2508. (10.1101/gad.439107)
- Papageorgiou, I. et al. 2007. Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 619(1-2), pp. 45-58. (10.1016/j.mrfmmm.2007.01.008)
- Baird, D. M. 2007. Telomeres II. Experimental Gerontology 43(1), pp. 15-19. (10.1016/j.exger.2007.10.002)
- Baird, D. M. 2006. Telomeres. Experimental Gerontology 41(12), pp. 1223-1227. (10.1016/j.exger.2006.09.009)
- Britt-Compton, B., Rowson, J. M., Locke, M., Mackenzie, I., Kipling, D. G. and Baird, D. M. 2006. Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Human Molecular Genetics 15(5), pp. 725-733. (10.1093/hmg/ddi486)
- Baird, D. M., Britt-Compton, B., Rowson, J. M., Amso, N. N., Gregory, L. and Kipling, D. G. 2006. Telomere instability in the male germline. Human molecular genetics 15(1), pp. 45-51. (10.1093/hmg/ddi424)
- Britt-Compton, B. and Baird, D. M. 2006. Intra-allelic mutation at human telomeres. Biochemical Society Transactions 34(4), pp. 581-582. (10.1042/BST0340581)
- Glaviano, A. et al. 2006. Effects of hTERT on metal ion-induced genomic instability. Oncogene 25(24), pp. 3424-3435. (10.1038/sj.onc.1209399)
- Baird, D. M. and Farr, C. J. 2006. The organization and function of chromosomes [Meeting Report]. EMBO Reports 7(4), pp. 372-376. (10.1038/sj.embor.7400661)
- Davis, T., Baird, D. M., Haughton, M. F., Jones, C. J. and Kipling, D. G. 2005. Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 60(11), pp. 1386-93.
- Baird, D. M. 2005. New developments in telomere length analysis. Experimental Gerontology 40(5), pp. 363-368. (10.1016/j.exger.2005.02.008)
- Baird, D. M., Davis, T., Rowson, J. M., Jones, C. J. and Kipling, D. G. 2004. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Human Molecular Genetics 13(14), pp. 1515-1524. (10.1093/hmg/ddh159)
- Baird, D. M. and Kipling, D. G. 2004. The extent and significance of telomere loss with age. Annals of the New York Academy of Sciences 1019(1), pp. 265-268. (10.1196/annals.1297.044)
- Pickett, H. A. et al. 2004. Telomere instability detected in sporadic colon cancers, some showing mutations in a mismatch repair gene. Oncogene 23(19), pp. 3434-3443. (10.1038/sj.onc.1207477)
- Cheung, I., Schertzer, M., Baross, A., Rose, A. M., Lansdorp, P. M. and Baird, D. M. 2004. Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Research 32(11), pp. 3383-3391. (10.1093/nar/gkh661)
- Baird, D. M., Rowson, J. M., Wynford-Thomas, D. and Kipling, D. G. 2003. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nature Genetics 33(2), pp. 203-207. (10.1038/ng1084)
- Baird, D. M., Coleman, J., Rosser, Z. and Royle, N. 2000. High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution. American Journal of Human Genetics 66(1), pp. 235-250. (10.1086/302721)
- Coleman, J., Baird, D. M. and Royle, N. J. 1999. The plasticity of human telomeres demonstrated by a hypervariable telomere repeat array that is located on some copies of 16p and 16q. Human Molecular Genetics 8(9), pp. 1637-1646. (10.1093/hmg/8.9.1637)
- Baird, D. M. and Royle, N. J. 1997. Sequences from higher primates orthologous to the human Xp/Yp telomere junction region reveal gross rearrangements and high levels of divergence. Human Molecular Genetics 6(13), pp. 2291-2299. (10.1093/hmg/6.13.2291)
- Baird, D. M., Jeffreys, A. J. and Royle, N. J. 1995. Mechanisms underlying telomere repeat turnover, revealed by hypervariable variant repeat distribution patterns in the human Xp/Yp telomere. EMBO Journal 14(21), pp. 5433-5443.
- Royle, N. J., Baird, D. M. and Jeffreys, A. J. 1994. A subterminal satellite located adjacent to telomeres in chimpanzees is absent from the human genome. Nature Genetics 6(1), pp. 52-56. (10.1038/ng0194-52)
Book sections
- Baird, D. M. 2007. Telomeres. In: Marshall, V. et al. eds. Encyclopaedia of Gerontology (2nd ed.). Amsterdam: Elsevier, pp. 593-601., (10.1016/B0-12-370870-2/00185-2)
Ymchwil
Telomeres are structures that cap the ends of chromosomes, they prevent the natural end of a chromosome from being recognised as a double-stranded DNA break. Telomeres shorten with ongoing cell division ultimately obtaining a length at which they become dysfunctional. Dysfunctional telomeres may either trigger replicative senescence or undergo fusion with other chromosome ends or non-telomeric DNA breaks. Fusion can result in the formation dicentric chromosomes and cycles of anaphase bridging, breakage and fusion, which in turn can cause large-scale, potentially oncogenic, genomic rearrangements such as non-reciprocal translocations.
The laboratory has developed high-resolution single molecule approaches to determine telomere length and to detect telomere fusion. They have been using these tools to understand the mechanisms of telomere erosion, mutation and fusion, as well undertaking translational work to examine the role of telomere dysfunction in tumour progression and to test the utility of telomere based prognostic markers in several tumour types.
Addysgu
Lecturer on the ‘Molecular and Cell Biology of Cancer’ module for the Medical Intercalated degree for 3rd and 4th year students from the Schools of Medicine and Dentistry.
Academic mentor for undergraduate medical students.
My laboratory hosts SSC medical student projects.
Host 3rd year Pharmacology Student Research Projects.
Supervision of full-time PhD students
Bywgraffiad
Aelodaethau proffesiynol
- Member of the Cardiff Institute of Tissue Engineering and Repair.
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol

Angelos Damo
