Mrs Emily Simmonds
Timau a rolau for Emily Simmonds
Cydymaith Ymchwil
Biowybodegydd
Cyhoeddiad
2026
- Escott-Price, V. et al. 2026. Genetic investigation of non-affective psychosis and depression as causal risk factors for dementia. BMJ Mental Health 29 (1) e302424. (10.1136/bmjment-2025-302424)
- Lock, S. K. et al. 2026. Near, far, wherever you are: phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature. Frontiers in Pharmacology 16 1719761. (10.3389/fphar.2025.1719761)
2025
- Kirov, G. et al. 2025. Risk of dementia after electroconvulsive therapy: a cohort study on the population of Wales. Acta Psychiatrica Scandinavica 152 (4), pp.270-277. (10.1111/acps.70005)
- Harrison, J. R. et al. 2025. White matter microstructure in mid- to late adulthood is influenced by pathway-stratified polygenic risk for Alzheimer’s disease. Frontiers in Neuroscience 19 1638503. (10.3389/fnins.2025.1638503)
- Simmonds, E. et al. 2025. Dementia risk due to traumatic brain injury in subtypes of dementia in the Welsh population. Neurology 105 (3) e213866. (10.1212/wnl.0000000000213866)
- Simmonds, E. et al. 2025. Sleep disturbances as risk factors for neurodegeneration later in life. npj Dementia 1 6. (10.1038/s44400-025-00008-0)
- Bellou, E. et al. 2025. Benchmarking Alzheimer's disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies. Alzheimer's Research and Therapy 17 (1) 6. (10.1186/s13195-024-01664-9)
2024
- Simmonds, E. et al. 2024. Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer’s disease in a European population. Translational Psychiatry 14 (1) 358. (10.1038/s41398-024-03058-9)
- Stevenson-Hoare, J. et al. 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27 (1) e301097. (10.1136/bmjment-2024-301097)
- Leonenko, G. et al. 2024. Dementias Platform UK: Bringing genetics into life. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20 (5), pp.3281-3289. (10.1002/alz.13782)
2023
- Steventon, J. J. et al. 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158 106393. (10.1016/j.psyneuen.2023.106393)
- Harrison, J. R. et al. 2023. Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults. Brain Communications 5 (5) fcad229. (10.1093/braincomms/fcad229)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60 , pp.636-643. (10.1136/jmg-2022-108862)
- Simmonds, E. et al. 2023. What does heritability of Alzheimer’s disease represent?. PLoS ONE 18 (4) e0281440. (10.1371/journal.pone.0281440)
2022
- Crawford, K. et al. 2022. Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing. Molecular Psychiatry (10.1038/s41380-022-01926-8)
- Bracher-Smith, M. et al. 2022. Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer’s disease pathogenesis. Neurobiology of Aging 119 , pp.67-76. (10.1016/j.neurobiolaging.2022.07.009)
- Mirza-Davies, A. et al. 2022. The impact of genetic risk for Alzheimer’s disease on the structural brain networks of young adults. Frontiers in Neuroscience 16 987677. (10.3389/fnins.2022.987677)
- Crawford, K. et al., 2022. Analysis of Alzheimer's disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathways. medRxiv (10.1101/2022.06.29.22276952)
- Chambers, T. et al. 2022. Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank. Molecular Psychiatry 27 , pp.2282-2290. (10.1038/s41380-022-01443-8)
2021
- Leonenko, G. et al. 2021. Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. Nature Communications 12 4506.
- Carpanini, S. M. et al. 2021. The impact of complement genes on the risk of late-onset Alzheimer's disease. Genes 12 (3) 443. (10.3390/genes12030443)
2020
- Bellou, E. et al. 2020. Age-dependent effect of APOE and polygenic component on Alzheimer's disease. Neurobiology of Aging 93 , pp.69-77. Neurobiology of Aging Volume 93, September 2020, Pages 69-77. (10.1016/j.neurobiolaging.2020.04.024)
- Baker, E. and Escott-Price, V. 2020. Polygenic risk scores in Alzheimer’s disease: current applications and future directions. Frontiers in Digital Health: Personalized Medicine 2 (14)(10.3389/fdgth.2020.00014)
2019
- Baker, E. et al. 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14 (7) e0218111. (10.1371/journal.pone.0218111)
- Escott-Price, V. et al. 2019. Genetic analysis suggests high misassignment rates in clinical Alzheimer's cases and controls. Neurobiology of Aging 77 , pp.178-182. (10.1016/j.neurobiolaging.2018.12.002)
- Vivian-Griffiths, T. et al. 2019. Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180 (1), pp.80-85. (10.1002/ajmg.b.32705)
2018
- Ahmad, S. et al., 2018. Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study. Alzheimer's and Dementia 14 (7), pp.848-857. (10.1016/j.jalz.2018.01.005)
- Baker, E. et al. 2018. POLARIS: polygenic LD-adjusted risk score approach for set-based analysis of GWAS data. Genetic Epidemiology 42 (4), pp.366-377. (10.1002/gepi.22117)
- Baker, E. A. 2018. Investigation of new strategies for identifying causal mechanisms in Alzheimer's disease taking bioinformatics approaches beyond GWAS. PhD Thesis , Cardiff University.
Articles
- Escott-Price, V. et al. 2026. Genetic investigation of non-affective psychosis and depression as causal risk factors for dementia. BMJ Mental Health 29 (1) e302424. (10.1136/bmjment-2025-302424)
- Lock, S. K. et al. 2026. Near, far, wherever you are: phenotype-related variation in pharmacogenomic effect sizes across the psychiatric drug literature. Frontiers in Pharmacology 16 1719761. (10.3389/fphar.2025.1719761)
- Kirov, G. et al. 2025. Risk of dementia after electroconvulsive therapy: a cohort study on the population of Wales. Acta Psychiatrica Scandinavica 152 (4), pp.270-277. (10.1111/acps.70005)
- Harrison, J. R. et al. 2025. White matter microstructure in mid- to late adulthood is influenced by pathway-stratified polygenic risk for Alzheimer’s disease. Frontiers in Neuroscience 19 1638503. (10.3389/fnins.2025.1638503)
- Simmonds, E. et al. 2025. Dementia risk due to traumatic brain injury in subtypes of dementia in the Welsh population. Neurology 105 (3) e213866. (10.1212/wnl.0000000000213866)
- Simmonds, E. et al. 2025. Sleep disturbances as risk factors for neurodegeneration later in life. npj Dementia 1 6. (10.1038/s44400-025-00008-0)
- Bellou, E. et al. 2025. Benchmarking Alzheimer's disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies. Alzheimer's Research and Therapy 17 (1) 6. (10.1186/s13195-024-01664-9)
- Simmonds, E. et al. 2024. Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer’s disease in a European population. Translational Psychiatry 14 (1) 358. (10.1038/s41398-024-03058-9)
- Stevenson-Hoare, J. et al. 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27 (1) e301097. (10.1136/bmjment-2024-301097)
- Leonenko, G. et al. 2024. Dementias Platform UK: Bringing genetics into life. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20 (5), pp.3281-3289. (10.1002/alz.13782)
- Steventon, J. J. et al. 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158 106393. (10.1016/j.psyneuen.2023.106393)
- Harrison, J. R. et al. 2023. Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults. Brain Communications 5 (5) fcad229. (10.1093/braincomms/fcad229)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60 , pp.636-643. (10.1136/jmg-2022-108862)
- Simmonds, E. et al. 2023. What does heritability of Alzheimer’s disease represent?. PLoS ONE 18 (4) e0281440. (10.1371/journal.pone.0281440)
- Crawford, K. et al. 2022. Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing. Molecular Psychiatry (10.1038/s41380-022-01926-8)
- Bracher-Smith, M. et al. 2022. Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer’s disease pathogenesis. Neurobiology of Aging 119 , pp.67-76. (10.1016/j.neurobiolaging.2022.07.009)
- Mirza-Davies, A. et al. 2022. The impact of genetic risk for Alzheimer’s disease on the structural brain networks of young adults. Frontiers in Neuroscience 16 987677. (10.3389/fnins.2022.987677)
- Crawford, K. et al., 2022. Analysis of Alzheimer's disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathways. medRxiv (10.1101/2022.06.29.22276952)
- Chambers, T. et al. 2022. Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank. Molecular Psychiatry 27 , pp.2282-2290. (10.1038/s41380-022-01443-8)
- Leonenko, G. et al. 2021. Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores. Nature Communications 12 4506.
- Carpanini, S. M. et al. 2021. The impact of complement genes on the risk of late-onset Alzheimer's disease. Genes 12 (3) 443. (10.3390/genes12030443)
- Bellou, E. et al. 2020. Age-dependent effect of APOE and polygenic component on Alzheimer's disease. Neurobiology of Aging 93 , pp.69-77. Neurobiology of Aging Volume 93, September 2020, Pages 69-77. (10.1016/j.neurobiolaging.2020.04.024)
- Baker, E. and Escott-Price, V. 2020. Polygenic risk scores in Alzheimer’s disease: current applications and future directions. Frontiers in Digital Health: Personalized Medicine 2 (14)(10.3389/fdgth.2020.00014)
- Baker, E. et al. 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14 (7) e0218111. (10.1371/journal.pone.0218111)
- Escott-Price, V. et al. 2019. Genetic analysis suggests high misassignment rates in clinical Alzheimer's cases and controls. Neurobiology of Aging 77 , pp.178-182. (10.1016/j.neurobiolaging.2018.12.002)
- Vivian-Griffiths, T. et al. 2019. Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180 (1), pp.80-85. (10.1002/ajmg.b.32705)
- Ahmad, S. et al., 2018. Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study. Alzheimer's and Dementia 14 (7), pp.848-857. (10.1016/j.jalz.2018.01.005)
- Baker, E. et al. 2018. POLARIS: polygenic LD-adjusted risk score approach for set-based analysis of GWAS data. Genetic Epidemiology 42 (4), pp.366-377. (10.1002/gepi.22117)
Thesis
- Baker, E. A. 2018. Investigation of new strategies for identifying causal mechanisms in Alzheimer's disease taking bioinformatics approaches beyond GWAS. PhD Thesis , Cardiff University.