Dr Kelly Berube

Darllenydd

: Sylwebydd y cyfryngau
: Ar gael fel goruchwyliwr ôl-raddedig

Ysgol y Biowyddorau

Mae Grŵp Ymchwil yr Ysgyfaint a Gronynnau (LPRG) yn arbenigo mewn 'Iechyd Amgylcheddol Moleciwlaidd'. Y prif ffocws ymchwil yw penderfynu biofarcwyr deallus o amlygiad a niwed yn y system anadlol ddynol ar ôl dod i gysylltiad â xenobiotics o'r awyr. Ein diddordeb penodol yw deall sut mae llygryddion (e.e. o waith dyn, biolegol, naturiol a diwydiannol) yn peryglu biocemeg / metaboledd yr ysgyfaint ac yn newid mynegiant genynnau a phrotein i yrru mecanweithiau clefydau. Mae ein hofferyn ymchwil allweddol yn cynnwys cynhyrchu cyfwerth â meinwe dynol yr epithelia, sy'n deillio o gilfach bôn-gelloedd samplau meinwe rhoddwyr cleifion, fel llwyfan amgen i fodelau anifeiliaid.

Rolau

Cydlynydd Arfer Annheg
Dirprwy Arweinydd Modiwl: BI2231 Bioleg Celloedd

Oes gennych chi ddiddordeb mewn ymuno â'm labordy fel myfyriwr ôl-raddedig hunan-ariannu neu bostdoc/cymrodyr? Cysylltwch â mi drwy e-bost.

Date
Type

2018

Perry, I., Sexton, K., Prytherch, Z., Jason, B., Judith, Z. and Berube, K. 2018. An in vitro versus in vivo toxicogenomics investigation of prenatal exposures to tobacco smoke. Applied In Vitro Toxicology 4(4), pp. 379-388. (10.1089/aivt.2016.0041)
Clippinger, A. J. et al. 2018. Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicology in Vitro 52, pp. 131-145. (10.1016/j.tiv.2018.06.009)
Berube, K. and Redmond, C. 2018. Editorial: The 2017 Lush Prize Awards. ATLA: Alternatives to Laboratory Animals
Moore, A., Davies, T., Berube, K., Jones, T. and Baillie, L. 2018. Bio-reactive clay minerals and anthrax decontamination: a novel antimicrobial solution. Presented at: Focused Meeting on Emerging Zoonoses and Antimicrobial Resistance, School of Veterinary Medicine, University of Surrey, Guildford, UK, 2 July 2018.
Clippinger, A. J. et al. 2018. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: an international workshop report. Toxicology in Vitro 48, pp. 53-70. (10.1016/j.tiv.2017.12.011)
Berube, K., Jones, T., Adams, R., Evans, S. and Ho, K. F. 2018. Particle-induced oxidative damage from exposure to airborne PM2.5 components in the vicinity of Hong Kong landfills. Presented at: DUST 2018: III International Conference on Atmospheric Dust, Bari, Italy, 29 May - 1 June 2018Scientific Research Abstracts, Vol. 8. Bari, Italy: Digilabs pp. 10.
Centeleghe, I., Myles, E., Baillie, L., Berube, K., Jones, T. and Blaxland, J. 2018. Combating the rising global threat of antimicrobial resistance with clay minerals: A study on two major hospital superbugs. Presented at: Focused meeting 2018: Emerging zoonoses and AMR: A global threat, University of Surrey, 02-02 July 2018.
Van Aardt, J., Bowell, R., Berube, K., Jones, T. and Lusambo, V. 2018. Geochemical and bioreactivity assessment of future mining operations at Mutanga Uranium Project, Southern Province, Zambia. Presented at: 11th ICARD | IMWA | WISA MWD 2018 Conference – Risk to Opportunity, Pretoria, 10-14 September 2018 Presented at Wolkersdorfer, C. et al. eds.Proceedings of the 11th ICARD | IMWA | MWD Conference - “Risk to Opportunity", Vol. 2. South Africa: Tshwane University of Technology (TUT) pp. 757-762.

2017

Berube, K. and Redmond, C. 2017. The 2016 Lush Prize Awards. Alternatives to the Laboratory Animals 45(5), pp. 221-226. (10.1177/026119291704500507)
Shao, L. et al. 2017. Seasonal variation of particle-induced oxidative potential of airborne particulate matter in Beijing. Science of the Total Environment 579, pp. 1152-1160. (10.1016/j.scitotenv.2016.11.094)

2016

Shao, L. et al. 2016. The oxidative potential of PM10 from coal, briquettes and wood charcoal burnt in an experimental domestic stove. Atmospheric Environment 127, pp. 372-381. (10.1016/j.atmosenv.2015.12.007)
BéruBé, K. A. and Redmond, C. 2016. The 2015 Lush Prize awards [Editorial]. ATLA Alternatives to Laboratory Animals 44, pp. 401-406.

2015

Lawson, M., Mol, L., Jones, T. P., Prytherch, Z. C. and Berube, K. A. 2015. Do ferrous-minerals in Arctic circle coal fly-ash mediate respiratory toxicity in humans?. Presented at: 2015 European Aerosol Conference (EAC 2015), Milan, Italy, 6-11 September 2015European Aerosol Society 2015 Digital Abstracts. European Aerosol Society 2015 Digital Abstracts Milan: European Aerosol Society pp. 1-1.
Berube, K. A. et al. 2015. Exposure and harm to combustion-derived wood particles. Presented at: 2015 European Aerosol Conference (EAC 2015), Milan, Italy, 6-11 September 2015European Aerosol Conference 2015 Digital Abstracts. Milan: European Aerosol Conference pp. 1-1.
Wlodarczyk, A. J., Arteaga-Salas, J., Jones, T. P., Zimmermann, R. and Berube, K. A. 2015. An 11 year study of multipollutant correlations of urban aerosols in Krakow, Poland. Presented at: European Aerosol Conference 2015, Milan, Italy, 6-11 September 2015. pp. -.
Wlodarczyk, A. J., Prytherch, Z. C., Huttunen, K. and Berube, K. A. 2015. Mimicking in vivo-like physiological properties of the human bronchial epithelium in in vitro 3-D cell cultures. Presented at: Early Career Physiologists' Symposium (ECPS) 2015: Cell Signalling in Health and Disease, Cardiff, UK, 5 July 2015. pp. -1.
Jones, T. P., Berube, K. A., Wlodarczyk, A. J., Prytherch, Z. C., Hassan, Y., Potter, S. and Adams, R. 2015. The bioreactivity of 'red clays' from basaltic terrains.. Presented at: EUROCLAY 2015, Edinburgh, UK, 5-10 July 2015.
Oeder, S. et al. 2015. Particulate matter from both heavy fuel oil and diesel fuel shipping emissions show strong biological effects on human lung cells at realistic and comparable in vitro exposure conditions. PLoS ONE 10(6), article number: e0126536. (10.1371/journal.pone.0126536)
Huttunen, K. et al. 2015. Reactive oxygen stress generating capacity and inflammatory potential of settled dust samples from moisture damaged and reference schools. Presented at: 13th ERS Lung Science Conference, Lung Infection and Immunity, Estoril, Portugal, 13-15 March 2015.
Moreno, T. et al. 2015. A new look at inhalable metalliferous airborne particles on rail subway platforms. Science of the Total Environment 505, pp. 367-375. (10.1016/j.scitotenv.2014.10.013)
Huttunen, K. et al. 2015. Toxicological responses of normal human bronchial epithelium (NHBE) model exposed to settled dust samples from moisture damaged and reference schools. Presented at: ERS International Congress 2015, Amsterdam, The Netherlands, 26-30 September 2015. pp. -.
Chuang, H. et al. 2015. Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study. International Journal of Nanomedicine 10, pp. 4705-4716. (10.2147/IJN.S82979)

2014

Prytherch, Z. C. and Berube, K. 2014. Modelling the human respiratory system: Approaches for in vitro safety testing and drug discovery. In: Human-based Systems for Translational Research. Royal Society of Chemistry, pp. 66-87., (10.1039/9781782620136-00066)
Berube, K. A. and Redmond, C. 2014. The 2013 Lush Prize awards [Editorial]. ATLA: Alternatives to Laboratory Animals 41(6)
Prytherch, Z. C. and Berube, K. A. 2014. A normal and biotransforming model of the human bronchial epithelium for the toxicity testing of aerosols and solubilised substances. Alternatives to Laboratory Animals: ATLA 42(6), pp. 377-381. (10.1177/026119291404200607)
Price, H. D., Arthur, R., Berube, K. A. and Jones, T. P. 2014. Linking particle number concentration (PNC), meteorology and traffic variables in a UK street canyon. Atmospheric Research 147-48, pp. 133-144. (10.1016/j.atmosres.2014.05.008)
Price, H. D. et al. 2014. Comparison of instruments for particle number size distribution measurements in airquality monitoring. Journal of Aerosol Science 76, pp. 48-55. (10.1016/j.jaerosci.2014.05.001)
Lui, W. et al. 2014. Physicochemical and biological characterisation of single-walled and double-walled carbon nanotubes in biological media. Journal of Hazardous Materials 280, pp. 216-225. (10.1016/j.jhazmat.2014.07.069)
Berube, K. A. et al. 2014. Exposure and harm to combustion-derived particles: Searching for biomarkers. Presented at: European Aerosol Conference 2013, Prague, Czech Republic, 1-6 September 2013.
Xiao, Z., Shao, L., Zhang, N., Chuang, H., Deng, Z., Wang, Z. and Berube, K. 2014. A toxicological study of inhalable particulates in an industrial region of Lanzhou City, northwestern China: results of a plasmid scission assay. Aeolian Research 14, pp. 25-34. (10.1016/j.aeolia.2014.03.004)
Price, H., Jones, T. P. and Berube, K. A. 2014. Resolution of the mediators of in vitro oxidative reactivity in size-segregated fractions that may be masked in the urban PM10 cocktail. Science of the Total Environment 485, pp. 588-595. (10.1016/j.scitotenv.2014.03.056)
Jones, T. P., Wlodarczyk, A. J. and Berube, K. A. 2014. Airborne particles: characterisation and bioreactivity. Presented at: Research meeting, Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland, 13 May 2014.
Chen, T. et al. 2014. Characterization of the interactions between protein and carbon black. Journal of Hazardous Materials 264, pp. 127-135. (10.1016/j.jhazmat.2013.10.055)
Adams, R. A., Al-Mosawi, A., Berube, K. A., Jones, T. P., Higgins, T. and Evans, S. -. 2014. Increased monocyte actin polymerization in rat blood after intratracheal instillation of air pollution particles. Biorheology 51(4-5), pp. 329-338. (10.3233/BIR-14027)
Prytherch, Z. C. and Berube, K. A. 2014. An in vitro NHBE model of the human bronchial epithelium. In: Haycock, J., Ahluwalia, A. and Wilkinson, M. eds. Cellular In Vitro Testing - Methods and Protocols. Pan Stanford, pp. 135-148., (10.4032/9789814364980)

2013

Berube, K. A. and Brown, K. 2013. The 2012 Lush Prize awards [Editorial]. ATLA: Alternatives to Laboratory Animals 41(6), pp. 419-422.
Chuang, H., Chen, T., Jones, T. P., BeruBe, K. A., Lin, C. and Cheng, T. 2013. Characterisation of protein-nanoparticleconjugates. Presented at: European Aerosol Assembly 2013, Prague, Czech Republic, 1-6 September 2013.
Wlodarczyk, A. J. and Berube, K. A. 2013. Testing particulate matter toxicity via in vitro methods: What should be tested?. Presented at: European Aerosol Conference 2013, Prague, Czech Republic, 1-6 September 2013 Presented at Drahas, J. and Hampl, V. eds.
Jones, T. P., Brown, P. and Berube, K. A. 2013. The respiratory toxicity of coal fly ash. Presented at: European Aerosol Conference 2013, Prague, Czech Republic, 1-6 September 2013.
Jones, T. P., Brown, P. and Berube, K. A. 2013. The respiratory toxicity of coal fly ash. Presented at: Workshop of Aerosol Emissionsfrom Fossil and Biomass Combustion, Prague, Czech Republic, August 27-31, 2013.
Chuang, H., Jones, T. P., Chen, T. and Berube, K. A. 2013. Alteration in oxidative stress and F-actin assembly by incense particles. Presented at: Workshop on Aerosol Emissions from Fossil and Biomass Combustion, Prague, Czech Republic, 27-31 August 2013.
Moreno, T. et al. 2013. Toxicological effects of indoor PM10 in urban primary schools in Barcelona, Spain. Presented at: Environment and Health – Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ, Basel, Switzerland, 19-23 August 2013.
Chuang, H., Jones, T. P., Chen, T. and Berube, K. A. 2013. Cytotoxic effects of incense particles in relation to oxidative stress, the cell cycle and F-actin assembly. Toxicology Letters 220(3), pp. 229-237. (10.1016/j.toxlet.2013.05.004)
Chuang, H., Berube, K. A., Lung, S. C., Bai, K. and Jones, T. P. 2013. Investigation into the oxidative potential generated by the formation of particulate matter from incense combustion. Journal of Hazardous Materials 244-5, pp. 142-150. (10.1016/j.jhazmat.2012.11.034)
Berube, K. A. 2013. Medical waste tissues - breathing life back into respiratory research. ATLA: Alternatives to Laboratory Animals 41(6), pp. 429-434.
Berube, K. A. ed. 2013. Special issue of Alternatives to Laboratory Animals: The 2012 Lush Science Prize. ATLA.

2012

Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
Moreno, T., Berube, K. A., Jones, T. P. and Gibbons, W. 2012. Toxicological effects of indoor PM10 in primary schools exposed to different street traffic intensities across the city of Barcelona, Spain. Presented at: European Aerosol Conference EAC-2012, Granada, Spain, 2-7 September 2012EAC-2012 Digital Abstracts Book. European Aerosol Assembly pp. 64.
Chuang, H., Jones, T. P. and Berube, K. A. 2012. Combustion particles emitted during church services: Implications for human respiratory health. Environmental International 40, pp. 137-142. (10.1016/j.envint.2011.07.009)
Reche, C. et al. 2012. A multidisciplinary approach to characterise exposure risk and toxicological effects of PM10 and PM2.5 samples in urban environments. Ecotoxicology and Environmental Safety 78, pp. 327-335. (10.1016/j.ecoenv.2011.11.043)
Price, H., Jones, T. P. and Berube, K. A. 2012. Size Segregated PM10 at an Urban Traffic Hotspot: Real-time Particle Number Concentration (PNC) Data. Presented at: 8th International Conference on Air Quality – Science and Application, Athens, Greece, 18-23 March 2012. pp. 252.
Adams, R., Al-Bulushi, H., Berube, K. A. and Jones, T. P. 2012. P14 Intratracheal instillation of air pollution particles in rats is associated with prolonged systemic inflammation, increased leukocyte intracellular F-actin and damage to the vascular endothelium. Biorheology 49(2, 3), pp. 206-206.

2011

Brown, P. D., Jones, T. P. and Berube, K. A. 2011. The internal microstructure and fibrous mineralogy of fly-ash from coal-burning power stations. Environmental Pollution 159(12), pp. 3324-3333. (10.1016/j.envpol.2011.08.041)
Prytherch, Z. C., Job, C. A., Marshall, H., Foster, M. and Berube, K. A. 2011. Tissue-specific stem cell differentiation in an in vitro airway model. Macromolecular Bioscience 11(11), pp. 1467-1477. (10.1002/mabi.201100181)
Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
Archibald, K. et al. 2011. Safety of medicine and the use of animals in research [Correspondence]. The Lancet 378(9802), pp. e2. (10.1016/S0140-6736(11)61669-3)
Berube, K. A. 2011. Trends in integrated testing strategies for in vitro to in vivo extrapolation in chemical and drug safety for inhalation toxicology. Biotech Online Magazine 22, pp. 10-14.
Jones, T. P. and Berube, K. A. 2011. The bioreactivity of the sub-10 μm component of volcanic ash: Soufrière Hills volcano, Montserrat. Journal of Hazardous Materials 194, pp. 128-134. (10.1016/j.jhazmat.2011.07.092)
Chuang, H., Jones, T. P., Chen, Y., Bell, J., Wenger, J. and Berube, K. A. 2011. Characterisation of airborne particles and associated organic components produced from incense burning. Analytical and Bioanalytical Chemistry 401(10) (10.1007/s00216-011-5209-7)
Chuang, H., Jones, T. P., Lung, S. C. and Berube, K. A. 2011. Soot-driven reactive oxygen species formation from incense burning. Science of the Total Environment 409(22), pp. 4781-4787. (10.1016/j.scitotenv.2011.07.041)
Berube, K. A., Gibson, C., Job, C. A. and Prytherch, Z. C. 2011. Human lung tissue engineering: a critical tool for safer medicines. Cell and Tissue Banking 12(1), pp. 11-13. (10.1007/s10561-010-9204-6)
Berube, K. A. 2011. Alternatives for lung research: Stuck between a rat and a hard place.. Presented at: ATLA Alternatives to Laboratory Animals, Kennel Club, London, 4 November 2010.

2010

Berube, K. A., Prytherch, Z. C., Job, C. A. and Hughes, T. G. 2010. Human primary bronchial lung cell constructs: the new respiratory models. Toxicology 278(3), pp. 311-318. (10.1016/j.tox.2010.04.004)
Adams, R. et al. 2010. Intratracheal instillation of air pollution nanoparticles into rats is associated with system inflammation and damage to vascular endothelium.. Presented at: Annual Aerosol Science Conference, University of Southampton, 8th - 9th April, 2010.
Price, H., Jones, T. P. and Berube, K. A. 2010. From particle collection to toxicological testing: a case study from Swansea, UK.. Presented at: Annual Aerosol Science Conference, University of Southampton, 8th - 9th April, 2010.
Berube, K. A., Pitt, A., Hayden, P., Prytherch, Z. C. and Job, C. A. 2010. Filter-well technology for advanced three-dimensional cell culture: perspectives for respiratory research. Alternatives to Laboratory Animals 38(S1), pp. 49-65.
Price, H. D. et al. 2010. Airborne particles in Swansea, UK: their collection and characterization. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 355-367. (10.1080/15287390903442652)
Jones, T. P., Brown, P. D., Berube, K. A., Wlodarczyk, A. J. and Longyi, S. 2010. The physicochemistry and toxicology of CFA particles. Journal of Toxicology and Environmental Health-Part A 73(5-6), pp. 341-354. (10.1080/15287390903442637)

2009

Jones, T. P. and Berube, K. A. 2009. Assessing the bioreactivity of respirable volcanic ash by adsorption of biological macrmolecules: a new geo-biology method. Presented at: Environment, Pollution and Human Health. William Smith meeting, The Geological Society, London, UK, 21st-23rd September 2009. pp. 25.
Koshy, L., Jones, T. P. and Berube, K. A. 2009. Geo-genomics of air and water pollution from landfills. Presented at: Environment, Pollution and Human Health. William Smith meeting, The Geological Society, London, UK, 21st-23rd September 2009. pp. 26.
Balharry, D., Sexton, K., Oreffo, V. and Berube, K. A. 2009. A novel application for Cocoacrisp protein as a biomarker for experimental pulmonary fibrosis. Biomarkers 14(6), pp. 366-371.
Koshy, L., Jones, T. P. and Berube, K. A. 2009. Characterization and bioreactivity of respirable airborne particles from a municipal landfill. Biomarkers 14(S1), pp. 49-53. (10.1080/13547500902965351)
Jones, T. P., Wlodarczyk, A. J., Koshy, L., Brown, P. D., Longyi, S. and Berube, K. A. 2009. The geochemistry and bioreactivity of fly-ash from coal-burning power stations. Biomarkers 14(S1), pp. 45-48. (10.1080/13547500902965195)
Price, H., Jones, T. P. and Berube, K. A. 2009. Particle concentration measurements in a busy street canyon: initial observations from Swansea, Wales. Presented at: 12th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, Institute of Environment and Health, Cranfield University, UK, 20-21 April 2009 Presented at Harrison, P. and Crump, D. eds.Proceedings of the 12th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 20-21 April 2009, Cranfield University. Web Report Vol. W26. Cranfield: Institute of Environment and Health, Cranfield University pp. 62-64.
Chuang, H., Jones, T. P. and Berube, K. A. 2009. Oxidative capacity of combustion-derived particulate matter from incense burning. Presented at: 12th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, Institute of Environment and Health, Cranfield University, UK, 20-21 April 2009 Presented at Harrison, P. and Crump, D. eds.Proceedings of the Twelth Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 20-21 April 2009, Cranfield University. Web Report Vol. W26. Cranfield: Institute of Environment and Health, Cranfield University pp. 49-55.

2008

Price, H., Berube, K. A., Matthews, I. P. and Jones, T. P. 2008. Nanoparticles in urban air: their collection, characterisation and potential health impacts. Presented at: The 9th International Conference on Particles: Risks and Opportunities, Cape Town, South Africa, 2nd-5th September 2008.
Balharry, D., Sexton, K. J. and Berube, K. A. 2008. An in vitro approach to assess the toxicity of inhaled tobacco smoke components: nicotine, cadmium, formaldehyde and urethane. Toxicology 244(1), pp. 66-76. (10.1016/j.tox.2007.11.001)
Koshy, L., Jones, T. P. and Berube, K. A. 2008. Bioreactivity of municipal solid waste landfill leachates-Hormesis and DNA damage. Water Research 42(8-9), pp. 2177-2183. (10.1016/j.watres.2007.11.030)
Sexton, K., Balharry, D. and Berube, K. A. 2008. Genomic biomarkers of pulmonary exposure to tobacco smoke components. Pharmacogenetics and Genomics 18(10), pp. 853-860. (10.1097/FPC.0b013e328307bddf)
Berube, K. A., Jones, T. P. and Jones, C. 2008. Environmental particles: a breath of fresh air?. infocus magazine (Royal Microscopical Society)(9), pp. 6-18.
Wlodarczyk, A. J., Koshy, L., Jones, T. P. and Berube, K. A. 2008. Reactive oxygen species drives coal fly ash bioreactivity. Presented at: 11th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, Cranfield, UK, 15-16 April 2008 Presented at Harrison, P. ed.Proceedings of the Eleventh Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 15–16 April 2008, Cranfield University. Web Report Vol. W25. Cranfield: Institute of Environment and Health, Cranfield University pp. 94-97.
Koshy, L., Jones, T. P. and Berube, K. A. 2008. Bioreactivity of airborne PM10 particle matter from a municipal solid waste landfill. Presented at: 11th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, Cranfield, UK, 15-16 April 2008 Presented at Harrison, P. ed.Proceedings of the Eleventh Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 15–16 April 2008, Cranfield University. Web Report Vol. W25. Cranfield: Institute of Environment and Health, Cranfield University pp. 89-93.
Price, H., Jones, T. P., Berube, K. A., Matthews, I. P. and Arthur, R. A. 2008. Nanoparticles in urban air: a very small problem. Presented at: 11th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, Institute of Environment and Health, Cranfield University, UK, 15-16 April 2008 Presented at Harrison, P. ed.Proceedings of the Eleventh Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 15–16 April 2008, Cranfield University. Web Report Vol. W25. Cranfield: Institute of Environment and Health, Cranfield University pp. 81-84.
Berube, K. A., Hughes, T. G., Prytherch, Z. C., Sexton, K. J., Koshy, L. and Jones, T. P. 2008. An In Vitro Human Tissue Equivalent Model of Respiratory Epithelia for Toxicological Screening of Inhaled Nanoparticles. Presented at: Nanotechnology: towards reducing animal testing, Institute of Nanotechnology, The Royal Society, London, UK, 28-29 May 2008.
Koshy, L., Jones, T. P. and Berube, K. A. 2008. Bioreactivity of leachate from municipal solid waste landfills. The Toxicologist CD - An official Journal of the Society of Toxicology 102(1), pp. 246.

2007

Berube, K. A., Balharry, D., Sexton, K. J., Koshy, L. and Jones, T. P. 2007. Combustion-derived nanoparticles: mechanisms of pulmonary toxicity. Clinical and Experimental Pharmacology and Physiology 34(10), pp. 1044-1050. (10.1111/j.1440-1681.2007.04733.x)
Koshy, L., Jones, T. P. and Berube, K. A. 2007. Bioreactivity of leachate from municipal waste landfills - assessments of toxicity. Presented at: SEGH. Environment and Human Health Conference and Workshop, Liverpool, UK, 4-7th June 2007.
Jones, T. P., Moreno, T., BéruBé, K., Gibbons, W. and Richards, R. J. 2007. A comment on Sillanpää et al. (2003) Field and laboratory tests of a high volume cascade impactor. Journal of Aerosol Science, 34, 485–500. [Letter]. Journal of Aerosol Science 38(1), pp. 136-138. (10.1016/j.jaerosci.2006.06.002)
Koshy, L., Paris, E. C., Ling, S. R., Jones, T. P. and Berube, K. A. 2007. Bioreactivity of leachate from municipal solid waste landfills - assessment of toxicity. Science of the Total Environment 384(1-3), pp. 171-181. (10.1016/j.scitotenv.2007.06.017)
Shao, L. et al. 2007. Associations between particle physicochemical characteristics and oxidative capacity: An indoor PM10 study in Beijing, China. Atmospheric Environment 41(26), pp. 5316-5326. (10.1016/j.atmosenv.2007.02.038)
Jones, T. P. and Berube, K. A. 2007. Mineralogy and structure of pathogenic particles. In: Donaldson, K. and Borm, P. eds. Particle Toxicology. Boca Raton, FL: CRC Press, pp. 13-46.
Berube, K. A., Balharry, D. C., Hicks, M., Sexton, K. J. and Jones, T. P. 2007. Inter-omic analysis of particulate air pollution. Presented at: 10th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, Institute of Environment and Health, Cranfield University, UK, 1-2 May 2007 Presented at Harrison, P. ed.Proceedings of the Tenth Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, 1–2 May 2007, Cranfield University. Web Report Vol. W24. Cranfield: Institute of Environment and Health, Cranfield University pp. 43-47.

2006

Evans, S. A., Al-Mosawi, A., Adams, R. A. and Berube, K. A. 2006. Inflammation, edema, and peripheral blood changes in lung-compromised rats after instillation with combustion-derived and manufactured nanoparticles. Experimental Lung Research 32(8), pp. 363-378. (10.1080/01902140600959671)
Jones, T. P., Moreno, T., Berube, K. A. and Richards, R. J. 2006. The physicochemical characterisation of microscopic airborne particles in south Wales: A review of the locations and methodologies. Science of the Total Environment 360(1-3), pp. 43-59. (10.1016/j.scitotenv.2005.08.055)
Berube, K. A. et al. 2006. Characterisation of airborne particulate matter and related mechanisms of toxicity: an experimental approach. In: Ayres, J., Maynard, R. and Richards, R. J. eds. Air Pollution and Health. Air Pollution Reviews Vol. 3. London: Imperial College Press, pp. 69-110.
Shao, L., Shi, Z., Jones, T. P., Li, J., Whittaker, A. G. and Berube, K. A. 2006. Bioreactivity of particulate matter in Beijing air: results from plasmid DNA assay. Science of the Total Environment 367(1), pp. 261-272. (10.1016/j.scitotenv.2005.10.009)
Sexton, K. J., Jones, T. P. and Berube, K. A. 2006. Biomarkers of exposure in the respiratory epithelia to tobacco smoke components [Abstract]. Experimental Lung Research 32(3-4), pp. 143. (10.1080/01902140600710603)
Balharry, D. C., Sexton, K. J. and Berube, K. A. 2006. Characterisation of the dose response of a human airway epithelium model in response to tobacco smoke components. Presented at: European Respiratory Society (ERS) Annual Congress, Munich, Germany, 2-6 September 2006. European Respiratory Society
Sexton, K. J., Balharry, D. C., Jones, T. P. and Berube, K. A. 2006. The use of toxicogenomics to identify biomarkers of exposure in an airway epithelium model exposed to tobacco smoke components. Presented at: European Respiratory Society (ERS) Annual Congress, Munich, Germany, 2-6 September 2006. European Respiratory Society

2005

Berube, K. A., Jones, T. P., Moreno, T. and Whittaker, A. G. 2005. Bioreactivity of airport-derived particles. Presented at: Mineralogical Society Winter meeting. Environmental Mineralogy, Geochemistry and Human Health, Bath Spa University, UK, 6-7th January 2005. pp. 27.
Whittaker, A. G., Berube, K., Jones, T. P., Moreno, T. and Merolla, L. L. 2005. London's killer smog: how did they kill?. Proceedings of the Royal Microscopical Society 40(3), pp. 171-183.
Jones, T. P., Berube, K. A. and Moreno, T. 2005. The characterisation of particles collected next to a waste transfer station [Abstract]. Experimental Lung Research 31(6), pp. 644. (10.1080/019021490952512)

2004

Berube, K. A., Jones, T. P., Housley, D. G. and Richards, R. J. 2004. The respiratory toxicity of airborne volcanic ash from the Soufrière Hills volcano, Montserrat. Mineralogical Magazine 68(1), pp. 47-60. (10.1180/0026461046810170)
Jones, T. P., Berube, K., Whittaker, A. G., Maynard, R. and Richards, R. J. 2004. Killer smog of London, 50 years on: particle properties and oxidative capacity. Science of the Total Environment 334-35, pp. 435-445. (10.1016/j.scitotenv.2004.04.047)
Berube, K. A., Sexton, K. J., Jones, T., Moreno, T., Anderson, S. and Richards, R. J. 2004. The spatial and temporal variations in PM10 mass from six UK homes. Science of the Total Environment 324(1-3), pp. 41-53. (10.1016/j.scitotenv.2003.11.003)

2003

Shi, Z. et al. 2003. Characterization of airborne individual particles collected in an urban area, a satellite city and a clean air area in Beijing, 2001. Atmospheric Environment 37(29), pp. 4047-4108. (10.1016/S1352-2310(03)00531-4)
Berube, K. A., Richards, R. J., Jones, T. P., Moreno, T., Thomas, S. and Nevalainen, A. 2003. Analysis of chemical and biological properties of indoor air particles. In: Morawska, L. and Salthammer, T. eds. Indoor Environment: Airborne Particles and Settled Dust. Weinheim: Wiley-VCH, pp. 105-140., (10.1002/9783527610013.ch2d)
Whittaker, A. G., Jones, T. P., Shao, L., Shi, Z., Berube, K. and Richards, R. J. 2003. Mineral dust in urban air: Beijing, China. Mineralogical Magazine 67(2), pp. 173-182. (10.1180/0026461036720111)
Reynolds, L., Jones, T. P., Berube, K., Wise, H. A. and Richards, R. J. 2003. Toxicity of Airborne Dust Generated by Opencast Coal Mining. Mineralogical Magazine 67(2), pp. 141-152. (10.1180/0026461036720091)
Berube, K. A., Jones, T. P., Sexton, K. J., Whittaker, A. G. and Richards, R. J. 2003. Quantitative Image Analysis of Urban Airborne Particulate Matter. Proceedings of the Royal Microscopical Society 38(1), pp. 1-10.
Berube, K. A., Jones, T. P., Moreno, T. and Whittaker, A. G. 2003. Characterization and toxicity of PM10 in the Gatwick airport region: a pilot study [Abstract]. Experimental Lung Research 30(6), pp. 531-532. (10.1080/01902140490476445)

2002

Timblin, C. R., Shukla, A., Berlanger, I., Berube, K. A., Churg, A. and Mossman, B. T. 2002. Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells. Toxicology and Applied Pharmacology 179(2), pp. 98-104. (10.1006/taap.2001.9343)
Housley, D. G., Berube, K. A., Jones, T. P., Anderson, S., Pooley, F. D. and Richards, R. J. 2002. Pulmonary epithelial response in the rat lung to instilled Montserrat respirable dusts and their major mineral components. Occupational & Environmental Medicine 59(7), pp. 466-472. (10.1136/oem.59.7.466)
Berube, K., Sexton, K. J., Jones, T. P., Anderson, S. and Richards, R. J. 2002. The life and times of airborne particles: a PM10 travel log [Abstract]. Experimental Lung Research 28(2), pp. 141. (10.1080/019021402753462059)
Whittaker, A. G., Jones, T. P., Berube, K. A., Shao, L., Shi, Z. and Richards, R. J. 2002. Characterisation and bioreactivity of real pollutant soots: London 1950s and Present day Beijing [Abstract]. Experimental Lung Research 28(2), pp. 142. (10.1080/019021402753462059)
Shi, Z., Shao, L., Whittaker, A. G., Jones, T. P., Berube, K. A. and Richards, R. J. 2002. Physicochemical Characterisation of the PM10 in Ambient Air of North Western Beijing Urban Area during the Heating-Period. Huan Jing Ke Xne 23(1), pp. 30-34.
Sexton, K. J., Berube, K. A., Jones, T. P. and Richards, R. J. 2002. Quantitative image analysis: the answer to a perfect figure [Abstract]. Experimental Lung Research 28(2), pp. 174. (10.1080/019021402753462059)
Whittaker, A., Jones, T. P., Berube, K. A. and Shao, L. 2002. Characterisation and bioreactivity of ‘old’ and ‘new’ pollutant soots. Presented at: 6th Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research, MRC Institute for Environment and Health, University of Leicester, 15-16 April Presented at Shuker, L. and Forster, P. eds.

2001

Whittaker, A. G., Jones, T. P., Berube, K. A. and Shao, L. 2001. Characterisation and bioreactivity of real pollutant soots: London 1950s and present day Beijing. Presented at: Old and New Occupational Exposures and the Lung - British Association for Lung Research Symposium, Leuven, Belgium, 6-8 September 2001.
Jones, T. P., Williamson, B. J., Berube, K. A. and Richards, R. J. 2001. Microscopy and chemistry of particles collected on TEOM filters: Swansea, South Wales, 1998-1999. Atmospheric Environment 35(21), pp. 3573-3583. (10.1016/S1352-2310(00)00570-7)
Whittaker, A. G., Jones, T. P., Berube, K. A. and Shao, L. 2001. Real pollutant soots: London 1950s and present day Beijing. Presented at: 5th Annual UK Review Meeting of the Joint Research Programmes on Outdoor and Indoor Air Pollution Research, University of Leicester, UK, April 2001.
Jones, T. P., Berube, K. A. and Richards, R. J. 2001. Characterisation of Montserrat volcanic ash for use in biological investigations. Presented at: Cities on Volcanoes 2 Conference, Auckland, New Zealand, 12-14 February 2001.
Jones, T. P., Blackmore, P., Leach, M., Berube, K., Sexton, K. J. and Richards, R. J. 2001. Characterisation of Airborne Particles Collected Within and Proximal to an Opencast Coalmine: South Wales, U.K.. Environmental Monitoring and Assessment 75(3), pp. 293-312. (10.1023/A:1014808419171)
Berube, K., Jones, T. P., Sexton, K. J. and Richards, R. J. 2001. A Comparison of Indoor and Outdoor PM10 Mass and Related particles [Abstract]. Experimental Lung Research 27(1), pp. 77. (10.1080/01902140119933)
Greenwell, L., Berube, K., Jones, T. P. and Richards, R. J. 2001. A Comparison between the PM10 Collections of Partisol and Negretti Collection Systems in Port Talbot, South Wales [Abstract]. Experimental Lung Research 27(1), pp. 77. (10.1080/01902140119933)
Whittaker, A. G., Shao, L., Shi, Z., Berube, K., Jones, T. P. and Richards, R. J. 2001. Change in PM10 and PM2.5 Levels over a 24 Hour Period in Central Beijing, China [Abstract]. Experimental Lung Research 27(1), pp. 106. (10.1080/01902140119933)
Jones, T. P., Berube, K. A. and Richards, R. J. 2001. Physicochemical characterisation of Montserrat volcanic ash for use in biological investigations. Presented at: Cities on Volcanoes 2 Conference, Auckland, New Zealand, 12-14 February 2001 Presented at Stewart, C. ed.Proceedings of the Cities on Volcanoes 2 Conference, Auckland, New Zealand, 12-14 February 2001. Institute of Geological and Nuclear Sciences Information Series Vol. 49. Lower Hutt, New Zealand: Institute of Geological and Nuclear Sciences pp. A169.
Richards, R. J., Housley, D. G., Berube, K. A. and Jones, T. P. 2001. Bioreactivity of Montserrat volcanic ash. Presented at: Cities on Volcanoes 2 Conference, Auckland, New Zealand, 12-14 February 2001 Presented at Stewart, C. ed.Proceedings of the Cities on Volcanoes 2 Conference, Auckland, New Zealand, 12-14 February 2001. Institute of Geological and Nuclear Sciences Information Series Vol. 49. Lower Hutt, New Zealand: Institute of Geological and Nuclear Sciences pp. A171.

2000

Jones, T. P., Berube, K. A., Reynolds, L. and Richards, R. J. 2000. Microscopy of airborne particles from open-cast coal pits. Presented at: Microscopy and Analysis, Philadelphia, PA, USA, 13-17 August 2000.
Shukla, A. et al. 2000. Inhaled particulate matter causes expression of nuclear factor (NF)-kappa B-related genes and oxidant-dependent NF-kappa B activation in vitro. American Journal of Respiratory Cell and Molecular Biology 23(2), pp. 182-187.
Berube, K., Jones, T. P. and Richards, R. J. 2000. Physicochemical identification and comparative biopersistence of indoor and outdoor airborne particulate matter [Abstract]. Presented at: Microscopy and Microanalysis 2002, Québec, Canada, 4-9 August 2002 Presented at Volkl, E. et al. eds.Proceedings: Microscopy and Microanalysis 2002. Vol. 8. Cambridge: Cambridge University Press pp. 914-915., (10.2277/ 0521824052)
Jones, T., Berube, K., Reynolds, L. and Richards, R. J. 2000. Microscopy of Airborne Particulates from Open-cast Coal Pits [Abstract]. Presented at: Microscopy and Microanalysis 2002, Qu�c, Canada, 4-9 August 2002 Presented at Volkl, E. et al. eds.Proceedings: Microscopy and Microanalysis 2002. Microscopy and Microanalysis Vol. 8. Cambridge: Cambridge University Press pp. 414-415., (10.2277/ 0521824052)
Reynolds, L., Berube, K., Jones, T. P. and Richards, R. J. 2000. Gene Expression profiling Following Instillation of Diesel Exhaust particles in the Lung: a first study [Abstract]. Presented at: Microscopy and Microanalysis 2002, Québec, Canada, 4-9 August 2002 Presented at Volkl, E. et al. eds.Proceedings: Microscopy and Microanalysis 2002. Microscopy and Microanalysis Vol. 8. Cambridge: Cambridge University Press pp. 910-911., (10.2277/ 0521824052)
Jones, T. P., Berube, K. A., Reynolds, L. and Richards, R. J. 2000. Physicochemical characterisation of some south Wales airborne particles: Park Slip West coal open-cast. Presented at: Natural Environment Research Council Urban Regeneration and Environment Programme Annual Meeting, 2000Proceedings of Natural Environment Research Council Urban Regeneration and Environment Programme Annual Meeting. Wallingford: NERC, Science Coordination Office pp. 21-22.
Jones, T. P., Berube, K. A., Reynolds, L. and Richards, R. J. 2000. Physicochemical characterisation of some south Wales airborne particles: Port Talbot. Presented at: Natural Environment Research Council Urban Regeneration and Environment Programme Annual Meeting, 2000Proceedings of Natural Environment Research Council Urban Regeneration and Environment Programme Annual Meeting. Wallingford: NERC, Science Coordination Office pp. 23-24.

1999

Murphy, S. A. M., Berube, K. A. and Richards, R. J. 1999. Bioreactivity of carbon black and diesel exhaust particles to primary Clara and type II epithelial cell cultures. Occupational and Environmental Medicine 56(12), pp. 813-819. (10.1136/oem.56.12.813)
Berube, K. A., Jones, T. P., Shao, L. and Richards, R. J. 1999. Physicochemical characterisation of carbonaceous particles: factors for assessing biological activity. Presented at: International Symposium on Mining Sciences and Technology, Beijing, China, 29-31 August 1999.
Berube, K. A., Dodge, J. D. and Ford, T. W. 1999. Effects of chronic salt stress on the ultrastructure of Dunaliella bioculata (Chlorophyta, Volvocales): mechanisms of response and recovery. European Journal of Phycology 34(2), pp. 117-123. (10.1080/09670269910001736172)
Shukla, A., Timblin, C., Cummins, A., Hemenway, D., Berube, K. A. and Mossman, B. 1999. Ambient particulate matter (PM2.5) induces multiple signalling pathways in rodent alveolar type II epithelial cells [Abstract]. American Journal of Respiratory and Critical Care Medicine 159(3 (S)), article number: A27.
Mudway, I. S., Zielinski, H., Berube, K. A., Murphy, S. A., Richards, R. and Kelly, F. J. 1999. Particle-antioxidant interactions in epithelial lining fluid [Abstract]. American Journal of Respiratory and Critical Care Medicine 159(3), pp. A26-A26.
Berube, K. A., Jones, T. P., Williamson, B. J. and Richards, R. J. 1999. The physicochemical characterisation of urban airborne particulate matter. In: Maynard, R. L. and Howard, V. eds. Particulate Matter: properties and effects upon health. Abingdon: Bios Scientific in association with the Royal Microscopical Society, pp. 39-62.
Williamson, B. J., Jones, T. P. and Berube, K. A. 1999. Calcareous algae: analytical techniques. In: Jones, T. P. and Rowe, N. P. eds. Fossil Plants and Spores: Modern Techniques. GSL Miscellaneous Titles London: Geological Society of London, pp. 285-289.
Berube, K. A., Jones, T. P., Williamson, B. J., Winters, C., Morgan, A. J., Pooley, F. D. and Richards, R. J. 1999. Physicochemical characterisation of diesel exhaust particles: Factors for assessing biological activity. Atmospheric Environment 33(10), pp. 1599-1614. (10.1016/S1352-2310(98)00384-7)
Berube, K. A. and Jones, T. P. 1999. Chinese anybody?. Biotype 9, pp. 58-59.

1998

Timblin, C. et al. 1998. Ambient particulate matter causes activation of the c-jun kinase stress-activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Research 58(20), pp. 4543-4547.
Murphy, S. A., Berube, K. A., Pooley, F. D. and Richards, R. J. 1998. Response of lung epithelium to well characterised fine particles. Life Sciences 62(19), pp. 1789-1799. (10.1016/S0024-3205(98)00141-6)
Quinlan, T. R. et al. 1998. Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models. Free Radical Biology and Medicine 24(5), pp. 778-788. (10.1016/S0891-5849(97)00357-2)
Berube, K. A., Jones, T. P., Williamson, B. J. and Richards, R. J. 1998. Physicochemical characterisation of urban particulate matter [Abstract]. Proceedings of the Royal Microscopical Society 33(2), pp. 101.
Jones, T. P., Berube, K. A. and Williamson, B. J. 1998. The microscopy of fossil soot: ancient PM10s. Proceedings of the Royal Microscopical Society 33(2), pp. 112-113.
Housely, D. G., Maynard, R., Berube, K. A., Jones, T. P., Pooley, F. D. and Richards, R. J. 1998. Epithelial response to instilled Montserrat and Antigua respirable dusts and their major mineral components [Abstract]. Respiratory Medicine 92(11), pp. A22. (10.1016/S0954-6111(98)90233-5)

1997

Berube, K. A., Jones, T. P. and Williamson, B. J. 1997. Electron microscopy of urban airborne particulate matter. Microscopy and Analysis 11(1), pp. 11-13.

1996

Berube, K. A., Quinlan, T. R., Fung, H., Magae, J., Vacek, P., Taatjes, D. J. and Mossman, B. T. 1996. Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos. American Journal of Respiratory Cell and Molecular Biology 15(1), pp. 141-147. (10.1165/ajrcmb.15.1.8679218)
Berube, K. A., Quinlan, T. R., Moulton, G., Hemenway, D., O'Shaughnessy, P., Vacek, P. and Mossman, B. T. 1996. Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos. Toxicology and Applied Pharmacology 137(1), pp. 67-74.
Roessler, J., Jones, T. P. and Berube, K. A. 1996. The determination of axis lengths of dunaliella from the image analysis of TEM sections through randomly orientated cells. Biometrical Journal 38(8), pp. 907-920. (10.1002/bimj.4710380803)

1995

Quinlan, T. R. et al. 1995. Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos. American Journal of Pathology 147(3), pp. 728-739.

1994

Berube, K. A., Roessler, J., Jones, T. P. and Janes, S. 1994. The determination of volume of dunaliella cells by transmission electron microscopy and image analysis. Annals of Botany 73(5), pp. 481-491. (10.1006/anbo.1994.1060)

Research interests

The LPRG specialises in 'Molecular Environmental Health', with a research focus on the "determination of intelligent biomarkers of exposure and harm" in the respiratory system following exposure to aerial xenobiotics.

The aerosols may be derived from anthropogenic (man-made; combustion-derived, cosmetics and pharmaceuticals), biogenic (biological; pollen, fungal spores and insect detritus), technogenic sources (industry; smelter and coal fly-ash) and geogenic (natural; volcanic ash and eroded earth minerals) sources.

Conducting research in this highly complex inter-disciplinary topic requires a structured coordination of expertise and contributions from various scientific disciplines including Chemistry, Physics, Biology, Medicine and Engineering. Understanding "mechanisms of human health effects caused by ambient aerosols" requires knowledge of the differential particle and gas phase effects. State-of-the-art technologies for comprehensive molecular characterisation of both the biological responses and the exposure characteristics are applied together with chemo-metric and bio-statistical analyses to achieve a 'holistic approach' towards inhalation toxicology.

Biomarkers (e.g. physical, chemical, inter-omic) of exposure and harm to indoor and outdoor air pollutants are identified using advanced in vitro aerosol exposure systems. Innovative human tissue-engineered equivalent models of the respiratory epithelia are employed to bridge the gap between the observed human health effects and air pollution-dependent lung injury and disease.

Biological responses, which can subsequently lead to health effects and diseases, are observed after exposure to aerosols, with reactive oxygen species (ROS) and reactive organic components (ROC) in the particulate and gas phases, along with their synergistic effects, the focal points of our investigations that encompass the following research aims:

Identification and quantification of ROS in relevant aerosol sources (e.g. traffic, wood combustion, incense burning, coal fly ash, cooking fumes, pharmaceuticals, cigarette smoke, cosmetics etc.); characterisation of the gas/particle partition of ROC
Development of in vitro ROS bio-assay (acellular/cellular) test systems for studies of effects induced by aerosol exposure
Exposure of these test systems to fresh aerosol emissions and aged aerosols from relevant sources
Differentiation between impact of the total aerosol and impact of the particulate phase and the gas phase
Analytical methods for comprehensive profiling of small molecules in biological systems and aerosol exposure
Toxicological characterisation and comprehensive response analysis at different hierarchical inter-omic levels (e.g. transcriptom, proteom, metabolom) of the biological test systems, in order to reveal exposure dependent alterations
Integrated chemo-metric and bio-statistical analysis of the data.

Recent grants awarded

Physicochemistry and toxicology of indoor source particles in Hong Kong; General Research Fund, Hong Kong Government, China. 2013-2016: Ho, K-F. (PI) & BéruBé K. (Co-PI)
Expanding networks within the scientific community: in vitro lung toxicology of combustion-derived particulate matter from vehicles, wood burners and ships. Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health (HICE), DFG. 2012-2017: Zimmerman, R. (PI) &BéruBé, K. (Co-PI & International Partner)
Toxicological analysis of wood smoke particulates from different species of trees. Helmholtz Zentrum Munchen, DFG. 2013-2014: BéruBé, K. (PI)
EUROCHAMP-2 translational access activity award: Year 2 PhD student (Hsiao-Chi Chuang) to identify reactive organic compounds in incense smoke. University of Cork, Ireland. 2012: BéruBé, K. (PI) & T. Jones
EU research studentship. Doctus-Malopolska Scholarship Fund, European Social Fund, State Budget Human Capital Operational Programme. 2012: BéruBé, K. (PI) & T. Jones
Air quality studies and toxicology (BREATHE). Spanish Government. 2012-2013: Moreno, T. (PI), Jones, T., BéruBé, K. (Co-PI)
Biotransformation Lung Model. Welsh Assembly Government UK. 2011-2013: BéruBé, K. (PI)
Characterisation of surgical smoke particles. Asalus Medical Instruments Ltd. UK. 2011-2012:BéruBé, K. (PI) & T. Jones
Toxicogenomics of mainstream cigarette smoke: in vitro versus in vivo investigation. Institute Science Health, USA. 2010-2011: BéruBé, K. (PI)
Physicochemical characteristics of ambient air particles responsible for dysregulation of pulmonary genes. Natural Environment Research Council UK. 2008-2011: Matthews, I (PI) & BéruBé, K. (Co-PI)
Respiratory toxicity of technogenic particles. Medical Research Council UK. 2008-2011: BéruBé, K. (PI) & Jones, T.
Intelligent biomarkers of exposure and harm in the respiratory epithelium following exposure to tobacco smoke. Institute Science Health, USA. 2008-2011: BéruBé, K. (PI)
Crohn's disease and mycobacterium avium subsp paratuberculosis, a public health tragedy whose resolution is long overdue. Natural Environment Research Council UK (Ecology Hydrology). 2008-2010: PI: Weightman, A., Jones, T. & BéruBé, K. (Co-Partner)
Pulmonary toxicity of incense smoke. Self-funded PhD student. 2008-2012: BéruBé, K (PI) & T. Jones
Toxicogenomic studies of air pollutants in 3-D a respiratory epithelial cell model. BBSRC-CASE PhD Studentship. 2008-2012: BéruBé, K. (PI) & Q-CHIP (Industrial Partner)
Nanotoxicology of urban air pollution. Natural Environment Research Council UK, Quota Studentship. 2008-2011: BéruBé, K. (PI) & T. Jones
Peroxiredoxin Oxidation in Lung Injury and COPD. AstraZeneca UK, PhD Studentship. 2008-2011:BéruBé, K. (PI)
Linkages between in-port ship emissions and effects on health. Environmental Protection Agency, Ireland. 2007-2011: Sodeau, J. (PI), BéruBé, K. (Co-Partner) & Jones, T.
Toxicity of Airborne Dust and Leachate Generated by Municipal Landfills. Natural Environment Research Council UK, Quota Studentship. 2007-2010: BéruBé, K. (PI) & T. Jones
In vitro human lung tissue culture for safety evaluation of candidate respiratory drugs.AstraZeneca UK. 2007-2010: BéruBé, K. (PI)
Toxicogenomic studies of air pollutants using 3-dimensional respiratory epithelial cell model. Q-Chip Ltd. UK. 2008-2009: BéruBé, K. (PI)
Validation of proteomic data: extension grant award for salary of one technician/extra consumables. Institute Science Health, USA. 2007-2008: BéruBé, K. (PI)
Bioreactivity of landfill leachates and particulate matter emissions. Natural Environment Research Council UK, Quota Studentship. 2005-2008: BéruBé, K. (PI) & T. Jones
Characterisation Laboratory for Environmental Engineering Research Mobile Environmental Monitoring Unit. Science Research Investment Fund 2, UK. 2005-2008: Jones, T., (PI), Matthews, I. & BéruBé, K. (Co-PI)

Current collaborations

Environmental Geology

Dr Timothy Jones School of Earth and Environmental Sciences, Cardiff University, Main Building, Park Place, Cardiff CF10 3YE, Wales, UK.
Professor Shao Long-Yi State Key Laboratory of Coal Resources and Safe Mining, College of Geoscience and Surveying Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China.

Air Pollution Epidemiology

Professor Ian Matthews Institute of Primary Care & Public Health, Cardiff University School of Medicine, Neuadd Meirionnydd, Heath Park, Cardiff CF14 4YS.

Dr Rachel Adams School of Health Sciences, Cardiff Metropolitan University, Western Avenue,Cardiff, CF5 2YB.

Monitoring, Collecting and Source Apportionment

Dr Teresa Moreno Instituto de Diagnóstico Ambiental y Estudios del Agua (IDÆA), Consejo Superior de Investigaciones Científicas (CSIC), C/ Jordi Girona 18-26, 08034 Barcelona, Spain.
Dr Heather Price Centre for Atmospheric and Instrumentation Research (CAIR), University of Hertfordshire, College Lane, Hatfield, AL10 9AB

Particle Toxicology

Dr Anna Wlodarcyk School of Biosciences, Lung & Particle Research Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
Dr Hsiao-Chi Chuang School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan & Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

In Vitro Toxicology

Dr Zoe Prytherch School of Biosciences, Lung & Particle Research Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.

Indoor and Outdoor Air Pollution

Professor Kin-Fai Ho School of Public Health, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong.
Professor Shih-Chun Lung Research Center for Environmental Changes, Academia Sinica, Nankang, Taipei, Taiwan 115.

Atmospheric Chemistry

Professor Ralf Zimmermann Institute of Chemistry, University of Rostock, Dr.-Lorenz-Weg 1, D-18051 Rostock /Germany & German Research Center for Environmental Health GmbH, Ingolstädter Landstraße 1, D-85764 Oberschleißheim/Germany.

Affiliated staff

Keith Sexton, Laboratory Manager
Dominique Balharry, Post-doctoral Research Assistant
Emma Paris, Post-doctoral Research Assistant
Lata Koshy, PhD Student
Tracy Hughes, PhD Student
Zoe Prytherch, PhD Student
Anna Wlodarcyk, MSc Student
Gaja Ramanathan, MSc Student
Robert Arthur, Post-doctoral Research Assistant

Research accolades

Dietrich Hoffmann Scientific Merit Award 2006: Institute of Science & Health, USA, for work on tobacco smoke: 'toxico-genomics of aerial xenobiotics'
British Toxicology Society Prize 2006: 4-week coast-to-coast (Melbourne to Perth) lecture tour on 'nano-toxicology' (universities, government labs, nano-tech companies)
NC3Rs UK Replacement Prize 2007: National Centre for Replacement, Refinement and Reduction of Animals in Research (NC3Rs) for 3-dimensional (3-D) cell culture models of human lung (Micro-Lung™) to replace use of animals in toxicology
Science & Technology Innovation Award 2007: in collaboration with Unilever (UK) for development of an in vitro 3-D human tissue-based lung model as an alternative to the use of animals in inhalation toxicology
Fellow Royal Society of Medicine 2008: for contributions towards understanding the medical effects of air pollution on human respiratory health
Director Nano-science Initiatives 2008: oversee nanotechnology issues/activities
Maximising Impact Award 2009. Awarded to staff in School of Biosciences that maximised impact of their research beyond normal expectations of their position
Feature Scientist Cheltenham Science Festival 2009: UK premier science fair, in association with 'New Scientist' and 'NC3Rs' - public debate on animals in research
Science & Technology Innovation Award 2010: in collaboration with Q-Chip (UK) for development of microfluidic-based in vitro human lung cell model for high-throughput screening in drug discovery
The Bill Annette Lecture Award 2010:FRAME UK (Federation for the Replacement of Animals in Medical Experiments) annual lecture: "Experimental models for lung research: stuck between a rat and a hard place"
Maximising Impact Award 2010. Awarded to staff that maximised impact of their research beyond normal expectations of their position
Scientific Advisor Safer Medicine Trust UK 2010: advocating 3Rs practices
NC3Rs UK Replacement Prize 2012: development of fully-metabolising 3-D cell culture model (Metabo-Lung™) for production of safer medicines
International Lush Science Prize 2013: for Metabo-Lung™ model

Dr Kelly BéruBé is the Director of the Lung & Particle Research Group at the School of Biosciences, Cardiff University, UK. With a background in electron microscopy and lung toxicology, she has built an international reputation in the field air pollution and human health and holds numerous appointments in the USA and UK on funding bodies, advisory councils, professional societies and journal editorial boards that focus on environmental health. Her research focuses on the determination of intelligent biomarkers of exposure and harm in the respiratory system, with a particular interest in understanding how pollutants compromise lung biochemistry and alter gene and protein expression to drive disease mechanisms.

Dr BéruBé's research has been recognised with a number of awards, including the Institute for Science & Health (USA) 'Scientific Merit Award 2006' for toxicogenomics of inhaled xenobiotics and the honour of being the British Toxicology Society 'Australasia Visitor 2006' to conduct a coast-to-coast lecture tour on nano-toxicology. Current work on 'human tissue equivalents of respiratory epithelia', as viable in vitro alternatives to animals for in vivo inhalation toxicology, was awarded the UK NC3Rs/MRC 'Replacement Prize' and the 'Science & Technology Innovation Prizes' in 2007 and 2010 and 2012. In 2013, her Metabo-Lung™ and Micro-Lung™ models won the prestigious international Lush 'Science Prize' for 3Rs research. Dr BéruBé's field of study is of natural interest to the general public, and as such, she is a prolific science writer and popular invited-speaker, and has worked extensively on communicating her research through public engagements of science for primary schools, laymen groups and professional learned societies. She is currently a feature scientist on the BBC children's science television show called 'Operation Ouch!'

Contact Details

Berube@caerdydd.ac.uk
+44 29208 76012
Adeilad Syr Martin Evans, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX

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Dr Kelly Berube

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