Dr Emma Blain

(hi/ei)

BSc PhD SFHEA

2024

• Gilbert, S. J. et al. 2024. Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models. Disease Models & Mechanisms 17(10), article number: dmm050583. (10.1242/dmm.050583)

2023

• Dintwa, L., Hughes, C. E. and Blain, E. J. 2023. Importance of mechanical cues in regulating musculoskeletal circadian clock rhythmicity: implications for articular cartilage. Physiological Reports 11(15), article number: e15780. (10.14814/phy2.15780)

2022

• Gilbert, S. J., Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32, article number: 101323. (10.1016/j.bbrep.2022.101323)
• Markov, P., Zhu, H., Boote, C. and Blain, E. J. 2022. Delayed reorganisation of F-actin cytoskeleton and reversible chromatin condensation in scleral fibroblasts under simulated pathological strain. Biochemistry and Biophysics Reports 32, article number: 101338.

2021

• Gilbert, S. J., Bonnet, C. S. and Blain, E. J. 2021. Mechanical cues: bidirectional reciprocity in the extracellular matrix drives mechano-signalling in articular cartilage. International Journal of Molecular Sciences 22(24), article number: 13595. (10.3390/ijms222413595)
• Markov, P., Hayes, A. J., Zhu, H., Boote, C. and Blain, E. J. 2021. 3D immuno-confocal image reconstruction of fibroblast cytoskeleton and nucleus architecture. Journal of Biophotonics 14(1), article number: e202000202. (10.1002/jbio.202000202)
• Stadnik, P. S. et al. 2021. Regulation of microRNA‐221, ‐222, ‐21 and ‐27 in articular cartilage subjected to abnormal compressive forces. Journal of Physiology 599(1), pp. 143-155., article number: V. (10.1113/JP279810)

2020

• Lawrence, E. A., Hammond, C. L. and Blain, E. J. 2020. Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration. Histochemistry and Cell Biology 154, pp. 521-531. (10.1007/s00418-020-01918-1)
• Bonnet, C. S., Gilbert, S. J., Blain, E. J., Williams, A. S. and Mason, D. J. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5(13), article number: e134055. (10.1172/jci.insight.134055)

2019

• Carter, J. and Blain, E. 2019. Effects of Superoxide Dismutase 1 on cartilage chondrocyte metabolism: a protective mechanism against ankle osteoarthritis?. The British Student Doctor Journal 3(3), pp. 35-37. (10.18573/bsdj.125)
• Pijanka, J. K. et al. 2019. Quantification of collagen fiber structure using second harmonic generation imaging and two‐dimensional discrete Fourier transform analysis: application to the human optic nerve head. Journal of Biophotonics 12(5), article number: e201800376. (10.1002/jbio.201800376)
• Al-Sabah, A., Burnell, S. E., Simoes, I. N., Jessop, Z., Badiei, N., Blain, E. and Whitaker, I. S. 2019. Structural and mechanical characterization of crosslinked and sterilised nanocellulose-based hydrogels for cartilage tissue engineering. Carbohydrate Polymers 212, pp. 242-251. (10.1016/j.carbpol.2019.02.057)
• Markov, P., Boote, C., Zhu, H. and Blain, E. 2019. Building a cell-specific cytoskeletal finite element model of scleral fibroblasts. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019), Vienna, Austria, 7-10 July 2019. pp. -.
• Markov, P., Boote, C., Zhu, H. and Blain, E. 2019. Effects of mechanical load on cytoskeletal protein arrangement in scleral fibroblasts. Presented at: The Association for Research in Vision and Ophthalmology Annual Meeting, Vancouver, BC, Canada, 28 April -- 2 May 2019.

2018

• Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
• Blain, E. and Duance, V. 2018. Meniscus. In: Hutson, M. and Speed, C. eds. Sports Injuries. Oxford UK: Oxford University Press, pp. 45-53.
• Gilbert, S. and Blain, E. 2018. Cartilage mechanobiology: how chondrocytes respond to mechanical load. In: Verbruggen, S. ed. Mechanobiology in Health and Disease. London UK: Elsevier, pp. 99-126.
• Markov, P., Blain, E. and Zhu, H. 2018. Can particle accelerators help prevent blindness?. Presented at: The UCL SenSyT (Sensory Systems, Technologies and Therapies) Symposium 2018, UCL, London, 3 December 2018.

2017

• Wilkinson, D. J. et al. 2017. The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover. Scientific Reports 7, article number: 16693. (10.1038/s41598-017-17028-3)

2016

• Khatib, N., Metcalfe, A., Blain, E., Mason, D. and Holt, C. 2016. Developing an in vitro model of healthy and OA medial knee compartmental loading. Osteoarthritis and Cartilage 24(Supp 1), pp. S344., article number: 564. (10.1016/j.joca.2016.01.617)
• Al-Sabah, A., Stadnik, P., Gilbert, S., Duance, V. and Blain, E. 2016. Importance of reference gene selection for articular cartilage mechanobiology studies. Osteoarthritis and Cartilage 24(4), pp. 719-730. (10.1016/j.joca.2015.11.007)
• Wyatt, H. L., Richards, R., Pullin, R., Yang, T. H. J., Blain, E. J. and Evans, S. 2016. Variation in electrosurgical vessel seal quality along the length of a porcine carotid artery. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 230(3), pp. 169-174. (10.1177/0954411915621092)

2015

• Ali, A. Y. et al. 2015. Anti-metastatic and cytotoxic properties of frankincense and scented myrrh. Anticancer Research 35(7), pp. 4310-4311.

2014

• Li, S., Blain, E. J., Cao, J., Caterson, B. and Duance, V. C. 2014. Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS ONE 9(10), article number: e109536. (10.1371/journal.pone.0109536)
• Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)

2012

• Blain, E. J., Thomas, R. S. and Duance, V. C. 2012. Effect of Wnt3A on load-induced markers of chondrocyte matrix metabolism. International Journal of Experimental Pathology 93(4), pp. A13-A14. (10.1111/j.1365-2613.2012.00822.x)
• Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.

2011

• Khan, I. M., Evans, S. L., Young, R. D., Blain, E. J., Quantock, A. J., Avery, N. and Archer, C. W. 2011. Fibroblast growth factor 2 and transforming growth factor β1 induce precocious maturation of articular cartilage. Arthritis & Rheumatism 63(11), pp. 3417-3427. (10.1002/art.30543)
• Wyatt, H. L., Richards, R., Evans, S. L., Pullin, R., Blain, E. J. and Yang, T. 2011. Relationship of tissue composition on arterial tissue adhesion strength. Presented at: 24th European Conference on Biomaterials ESB2011, Dublin, Ireland, 4-9 September 2011.
• Dachtler, J., Hardingham, N. R., Glazewski, S., Wright, N. F., Blain, E. J. and Fox, K. D. 2011. Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. Journal of Neuroscience 31(31), pp. 11220-11230. (10.1523/JNEUROSCI.1590-11.2011)
• Li, S., Jia, X., Duance, V. C. and Blain, E. J. 2011. The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study. European Cells and Materials 21, pp. 508-522.
• Blain, E. J. and Duance, V. C. 2011. Tissue injury and repair : meniscus. In: Hutson, M. and Speed, C. eds. Sports Injuries. Oxford: Oxford, pp. 45-53.
• Thomas, R. S., Clarke, A. R., Duance, V. C. and Blain, E. J. 2011. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Research and Therapy 13(6), article number: R203. (10.1186/ar3536)

2010

• Wann, A. K. T., Mistry, J., Blain, E. J., Michael-Titus, A. T. and Knight, M. M. 2010. Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Research & Therapy 12(6), article number: R207. (10.1186/ar3183)
• Blain, E. J., Ali, A. Y. and Duance, V. C. 2010. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytotherapy Research 24(6), pp. 905-912. (10.1002/ptr.3055)

2009

• Li, S., Jia, X., Duance, V. C. and Blain, E. J. 2009. The effects of cyclic tensile strain on cytoskeleton in intervertebral disc cell: a preliminary study in vitro [Abstract]. International Journal of Experimental Pathology 90(2), pp. A120. (10.1111/j.1365-2613.2008.00644.x)
• Harrison, R. J., Blain, E. J., Wardale, R. J. and Duance, V. C. 2009. Involvement of the cytoskeleton in the regulation of articular chondrocyte phenotype in 3D-culture [Abstract]. International Journal of Experimental Pathology 90(2), pp. A112-A113. (10.1111/j.1365-2613.2008.00644.x)
• Blain, E. J., Hughes, N., Kozaci, L. D. and Sutton, C. 2009. Cartilage metabolism and cell based therapies for tissue regeneration [Conference Report]. International Journal of Experimental Pathology 90(2), pp. A85-A93. (10.1111/j.1365-2613.2008.00644.x)
• Blain, E. J. 2009. The role of the cytoskeleton in articular chondrocyte metabolism [Abstract]. International Journal of Experimental Pathology 90(1), pp. A45. (10.1111/j.1365-2613.2008.00612.x)
• Blain, E. J. 2009. Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology. International Journal of Experimental Pathology 90(1), pp. 1-15. (10.1111/j.1365-2613.2008.00625.x)
• Harrison, R. J., Blain, E. J., Wardale, R. J. and Duance, V. C. 2009. Comparison of gene expression of human chondrocytes in monolayer and 3D-culture [Abstract]. International Journal of Experimental Pathology 90(1), pp. A66. (10.1111/j.1365-2613.2008.00612.x)
• Blain, E. J. 2009. BSMB young investigator award abstract the role of the cytoskeleton in articular chondrocyte metabolism. International Journal of Experimental Pathology 90(1), pp. A45-A45. (10.1111/j.1365-2613.2008.00612.x)

2008

• Davies, L. C., Blain, E. J., Caterson, B. and Duance, V. C. 2008. Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes. Osteoarthritis and Cartilage 16(8), pp. 855-864. (10.1016/j.joca.2007.12.005)
• Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
• Davies, L. C., Blain, E., Gilbert, S. J., Caterson, B. and Duance, V. 2008. The potential of IGF-1 and TGFβ1 for promoting “adult” articular cartilage repair: An in vitro study. Tissue Engineering Part A 14(7), pp. 1251-1261. (10.1089/ten.tea.2007.0211)
• Li, S., Duance, V. C. and Blain, E. J. 2008. Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc. Journal of Anatomy 213(6), pp. 725-732. (10.1111/j.1469-7580.2008.00998.x)
• Bazou, D., Blain, E. J. and Terence Coakley, W. 2008. NCAM and PSA-NCAM dependent membrane spreading and F-actin reorganization in suspended adhering neural cells. Molecular Membrane Biology 25(2), pp. 102-114. (10.1080/09687680701618365)

2007

• Blain, E. J., Li, S. and Duance, V. C. 2007. F-actin cytoskeletal organization in intervertebral disc health and disease. Biochemical Society Transactions 35(4), pp. 683-685. (10.1042/BST0350683)
• Blain, E. J. 2007. Mechanical regulation of matrix metalloproteinases. Frontiers in Bioscience 12(1), pp. 507-527. (10.2741/2078)
• Campbell, J. J., Blain, E. j., Chowdhury, T. T. and Knight, M. M. 2007. Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications 361(2), pp. 329-334. (10.1016/j.bbrc.2007.06.185)

2006

• Blain, E. J., Gilbert, S. J., Hayes, A. J. and Duance, V. C. 2006. Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis.. Matrix biology 25(7), pp. 398-408. (10.1016/j.matbio.2006.06.002)
• Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
• Davies, L., Blain, E. J., Caterson, B. and Duance, V. C. 2006. Comparing the responsiveness of chondrocytes isolated from young and mature articular cartilage to IGF-1 and TGFβ1. European Cells and Materials 12(Supp 1), pp. 54-54.
• Blain, E. J. and Duance, V. C. 2006. Maintenance of chondrocyte phenotype by the vimentin intermediate filaments [Abstract]. European Cells and Materials 12(S. 1), pp. 53.

2005

• Blain, E. J., Donaldson, E. and Cheung, F. 2005. British Society for Matrix Biology Spring 2005 meeting. University of Liverpool. Collagen-from genes to fibrils. International Journal of Experimental Pathology 86(6), pp. A57-A94. (10.1111/j.0959-9673.2005.00454.x)
• Blain, E. J., Gilbert, S. J. and Duance, V. C. 2005. An intact cytoskeleton is essential to maintain articular cartilage chondrocyte metabolism. International Journal of Experimental Pathology 86(3), pp. A10-A11. (10.1111/j.0959-9673.2005.00426.x)

2004

• Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)

2003

• Blain, E. J., Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40(1-3), pp. 111-117.

2002

• Blain, E. J., Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30(6), pp. 879-882. (10.1042/BST0300879)

2001

• Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)