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Yr Athro Timothy Bowen
(e/fe)
Timau a rolau for Timothy Bowen
Cadeirydd, Ysgol Meddygaeth
Trosolwg
Crynodeb Personol
Fy rôl i yw Athro Matrix a Bioleg Foleciwlaidd yn Uned Ymchwil Aren Cymru yn yr Is-adran Heintiau ac Imiwnedd.
Mae ein hymchwil yn canolbwyntio ar nodi ffactorau sy'n rheoli mynegiant genynnau mewn anhwylderau'r arennau, a throsi canfyddiadau arbrofol yn ddulliau arloesol ar gyfer diagnosis a thriniaeth.
Cyhoeddiad
2024
- Lu, Y. et al. 2024. Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing. Scientific Reports 14 (1) 24041. (10.1038/s41598-024-73102-7)
- Smith, T. et al. 2024. Robust rat and mouse models of bilateral renal ischemia reperfusion injury. In Vivo 38 (3), pp.1049-1057. (10.21873/invivo.13538)
2023
- Smith, D. A. et al. 2023. Identification and detection of microRNA kidney disease biomarkers in liquid biopsies. Current Opinion in Nephrology and Hypertension 32 (6), pp.515-521. (10.1097/MNH.0000000000000927)
- Grigorieva, I. et al. 2023. Hyaluronan in kidney fibrosis. In: Passi, A. ed. Hyaluronan: Structure, Biology and Biotechnology. Vol. 14, Biology of Extracellular Matrix Springer. , pp.77-97. (10.1007/978-3-031-30300-5_5)
2022
- Wonnacott, A. et al. 2022. MicroRNAs and their delivery in diabetic fibrosis. Advanced Drug Delivery Reviews 182 114045. (10.1016/j.addr.2021.114045)
2021
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32 (10), pp.2501-2516. (10.1681/ASN.2020081143)
- Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297 (3) 100987. (10.1016/j.jbc.2021.100987)
- Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11 (1) 16499. (10.1038/s41598-021-94984-x)
- Smith, D. A. et al. 2021. Detection of urinary microRNA biomarkers using diazo sulfonamide-modified screen printed carbon electrodes. RSC Advances 11 (31), pp.18832-18839. (10.1039/D0RA09874D)
- Khalid, U. et al. 2021. Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. Scientific Reports 11 (1) 9862. (10.1038/s41598-021-89195-3)
2019
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9 10136. (10.1038/s41598-019-46585-y)
- Khalid, U. et al. 2019. A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplant. Scientific Reports 9 3584. (10.1038/s41598-019-38642-3)
2018
- Thomas, M. , Fraser, D. and Bowen, T. 2018. Biogenesis, stabilization, and transport of microRNAs in kidney health and disease. Non-Coding RNA 4 (4), pp.30. 30. (10.3390/ncrna4040030)
- Beltrami, C. et al., 2018. Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. American Journal of Pathology 188 (9), pp.1982-1992. (10.1016/j.ajpath.2018.06.006)
2017
- Smith, D. et al. 2017. Electrochemical detection of urinary microRNAs via sulfonamide-bound antisense hybridisation. Sensors and Actuators B: Chemical 253 , pp.335-341. (10.1016/j.snb.2017.06.069)
- Wonnacott, A. , Bowen, T. and Fraser, D. 2017. MicroRNAs as biomarkers in chronic kidney disease. Current Opinion in Nephrology and Hypertension 26 (6), pp.460-466. (10.1097/MNH.0000000000000356)
- Lopez-Anton, M. et al., 2017. miR-21 promotes fibrogenesis in peritoneal dialysis. American Journal of Pathology 187 (7), pp.1537-1550. (10.1016/j.ajpath.2017.03.007)
- Lopez Anton, M. et al. 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164 , pp.37-40. (10.1016/j.mad.2017.03.010)
2016
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197 (6), pp.2195-2207. (10.4049/jimmunol.1600990)
- Martin, J. et al. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291 , pp.13789-13801. (10.1074/jbc.M115.670521)
- Simpson, K. et al. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16 (3) 35. (10.1007/s11892-016-0724-8)
- Khalid, U. et al. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30 (2), pp.99-104. (10.1111/ctr.12679)
- Chavez, R. et al. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3 1. (10.7243/2055-091X-3-1)
2015
- Khalid, U. et al. 2015. Urinary microrna expression predicts delayed graft function in kidney transplantation [Abstract]. Transplant International 28 (S4), pp.367-367. (10.1111/tri.12702)
- Beltrami, C. et al., 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1 (2), pp.151-166. (10.3390/ncrna1020151)
- Bowen, T. et al. 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015 427038. (10.1155/2015/427038)
- Jenkins, R. et al. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30 (iii262)(10.1093/ndt/gfv180.15)
2014
- Vigetti, D. et al., 2014. Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation. Journal of Biological Chemistry 289 (42), pp.28816-28826. (10.1074/jbc.M114.597401)
- Khalid, U. et al. 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42 (4), pp.1219-1223. (10.1042/BST20140093)
- Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184 (4), pp.996-1009. (10.1016/j.ajpath.2013.12.028)
- Midgley, A. C. et al. 2014. MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. Aging Cell 13 (2), pp.235-244. (10.1111/acel.12167)
2013
- Benitez, A. et al., 2013. Dietary supplement hymecromone and sorafenib: A novel combination for the control of renal cell carcinoma. The Journal of Urology 190 (1), pp.285-290. (10.1016/j.juro.2012.12.011)
- Bowen, T. , Jenkins, R. H. and Fraser, D. J. 2013. MicroRNAs, transforming growth factor Beta-1, and tissue fibrosis. The Journal of Pathology 229 (2), pp.274-285. (10.1002/path.4119)
- Midgley, A. C. et al. 2013. Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation Is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Journal of Biological Chemistry 288 (21), pp.14824-14838. (10.1074/jbc.M113.451336)
2012
- Beltrami, C. et al. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4), pp.875-879. (10.1042/BST20120090)
- Bowen, T. 2012. A role for fibrocytes in peritoneal fibrosis?. Peritoneal Dialysis International 32 (1), pp.4-6. (10.3747/pdi.2011.00071)
- Jenkins, R. H. et al. 2012. Pleiotropy of microRNA-192 in the kidney. Biochemical Society Transactions 40 (4), pp.762-767. (10.1042/BST20120085)
- Jenkins, R. H. et al. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443 (2), pp.407-416. (10.1042/BJ20111861)
2011
- Michael, D. R. et al. 2011. The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell. Journal of Biological Chemistry 286 (22), pp.19523-19532. (10.1074/jbc.M111.233916)
- Martin, J. et al. 2011. Post-transcriptional regulation of transforming growth factor beta-1 by microrna-744. PLoS ONE 6 (10) e25044. (10.1371/journal.pone.0025044)
- Khammas, H. et al. 2011. Characterisation of the human ADAM15 promoter. Nephron Experimental Nephrology 118 (2), pp.e27-e38. (10.1159/000320698)
2009
- Simpson, R. M. L. et al. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175 (5), pp.1915-1928. (10.2353/ajpath.2009.090045)
- Zhang, L. et al. 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284 (39), pp.26447-26455. (10.1074/jbc.M109.003616)
2008
- Nair, S. et al., 2008. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. Journal of Nephology 21 (3), pp.400-405.
2007
- Meran, S. et al. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282 (35), pp.25687-25697. (10.1074/jbc.M700773200)
- Saavalainen, K. et al., 2007. Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB. Journal of Biological Chemistry 282 (15), pp.11530-11539. (10.1074/jbc.M607871200)
2006
- Martin, J. , Bowen, T. and Steadman, R. 2006. The pluripotent cytokine pleiotrophin is induced by wounding in human mesangial cells. Kidney International 70 (9), pp.1616-1622. (10.1038/sj.ki.5001800)
- Monslow, J. et al., 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281 (26), pp.18043-18050. (10.1074/jbc.M510467200)
- Bowen, T. et al. 2006. Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells. Journal of the American Society of Nephrology 17 (6), pp.1553-67. (10.1681/ASN.2005080879)
- Rashid Selbi, W. et al. 2006. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. Kidney International 70 (7), pp.1287-1295. (10.1038/sj.ki.5001760)
2005
- Topley, N. , Michael, D. R. and Bowen, T. 2005. CA125: holy grail or a poisoned chalice. Nephron Clinical Practice 100 (2), pp.c52-c54. (10.1159/000085033)
2004
- Monslow, J. et al., 2004. Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 279 (20), pp.20576-20581. (10.1074/jbc.M312666200)
2003
- Hoogendoorn, B. et al. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12 (18), pp.2249-2254. (10.1093/hmg/ddg246)
- Monslow, J. et al., 2003. The human hyaluronan synthase genes: genomic structures, proximal promoters and polymorphic microsatellite markers. The International Journal of Biochemistry & Cell Biology 35 (8), pp.1272-1283. (10.1016/S1357-2725(03)00048-7)
2002
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7 (5), pp.508-514. (10.1038/sj.mp.4001030)
2001
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6 (3), pp.259-260. (10.1038/sj.mp.4000128)
2000
- Vincent, J. B. et al., 2000. Long repeat tracts at SCA8 in major psychosis. American Journal of Medical Genetics 96 (6), pp.873-876. (10.1002/1096-8628(20001204)96:6<873::AID-AJMG37>3.0.CO;2-9)
- Austin, J. et al., 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5 (2), pp.208-212. (10.1038/sj.mp.4000693)
- Bowen, T. et al. 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2 (4), pp.328-331. (10.1034/j.1399-5618.2000.020406.x)
- Bowen, T. et al. 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10 (1), pp.33-37. (10.1097/00041444-200010010-00006)
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10 (2), pp.83-86. (10.1097/00041444-200010020-00005)
- Williams, N. et al. 2000. Identification and characterisation of SNPs in candidate genes for schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96 (4), pp.462.
1999
- Cardno, A. G. et al., 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45 (12), pp.1592-1596. (10.1016/s0006-3223(99)00033-5)
- Franks, E. et al., 1999. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics 88 (1), pp.67-70. (10.1002/(SICI)1096-8628(19990205)88:1<67::AID-AJMG12>3.0.CO;2-#)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88 (1), pp.57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Bowen, T. et al. 1999. Linkage studies of bipolar disorder with chromosome 18 markers. American Journal of Medical Genetics 15 (88), pp.503-509. (10.1002/(SICI)1096-8628(19991015)88:5<503::AID-AJMG13>3.0.CO;2-U)
- Guy, C. et al. 1999. CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder. Neurobiology of Disease 6 (4), pp.302-307. (10.1006/nbdi.1999.0249)
- Williams, N. M. et al. 1999. Polymorphism screening and association studies of the Wolfram syndrome gene in schizophrenia. Molecular Psychiatry 4 (supp1), pp.S42-S42.
1998
- Bowen, T. et al. 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3 (3), pp.266-269. (10.1038/sj.mp.4000400)
- Bowen, T. et al. 1998. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Molecular Psychiatry 3 (1), pp.67-71. (10.1038/sj.mp.4000293)
- Cardno, A. G. et al., 1998. Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]. Psychiatric Genetics 8 (1), pp.29-32. (10.1097/00041444-199800810-00005)
1997
- Speight, G. et al., 1997. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. American Journal of Medical Genetics 74 (2), pp.204-206. (10.1002/(SICI)1096-8628(19970418)74:2<204::AID-AJMG19>3.0.CO;2-M)
- Guy, C. et al. 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154 (8), pp.1146-1147.
1996
- O'Donovan, M. C. et al. 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine -London- 26 (6), pp.1145-1153. (10.1017/s0033291700035868)
- Bowen, T. et al. 1996. Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set. American Journal of Human Genetics 59 (4), pp.912-917.
Articles
- Lu, Y. et al. 2024. Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing. Scientific Reports 14 (1) 24041. (10.1038/s41598-024-73102-7)
- Smith, T. et al. 2024. Robust rat and mouse models of bilateral renal ischemia reperfusion injury. In Vivo 38 (3), pp.1049-1057. (10.21873/invivo.13538)
- Smith, D. A. et al. 2023. Identification and detection of microRNA kidney disease biomarkers in liquid biopsies. Current Opinion in Nephrology and Hypertension 32 (6), pp.515-521. (10.1097/MNH.0000000000000927)
- Wonnacott, A. et al. 2022. MicroRNAs and their delivery in diabetic fibrosis. Advanced Drug Delivery Reviews 182 114045. (10.1016/j.addr.2021.114045)
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32 (10), pp.2501-2516. (10.1681/ASN.2020081143)
- Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297 (3) 100987. (10.1016/j.jbc.2021.100987)
- Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11 (1) 16499. (10.1038/s41598-021-94984-x)
- Smith, D. A. et al. 2021. Detection of urinary microRNA biomarkers using diazo sulfonamide-modified screen printed carbon electrodes. RSC Advances 11 (31), pp.18832-18839. (10.1039/D0RA09874D)
- Khalid, U. et al. 2021. Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. Scientific Reports 11 (1) 9862. (10.1038/s41598-021-89195-3)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9 10136. (10.1038/s41598-019-46585-y)
- Khalid, U. et al. 2019. A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplant. Scientific Reports 9 3584. (10.1038/s41598-019-38642-3)
- Thomas, M. , Fraser, D. and Bowen, T. 2018. Biogenesis, stabilization, and transport of microRNAs in kidney health and disease. Non-Coding RNA 4 (4), pp.30. 30. (10.3390/ncrna4040030)
- Beltrami, C. et al., 2018. Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. American Journal of Pathology 188 (9), pp.1982-1992. (10.1016/j.ajpath.2018.06.006)
- Smith, D. et al. 2017. Electrochemical detection of urinary microRNAs via sulfonamide-bound antisense hybridisation. Sensors and Actuators B: Chemical 253 , pp.335-341. (10.1016/j.snb.2017.06.069)
- Wonnacott, A. , Bowen, T. and Fraser, D. 2017. MicroRNAs as biomarkers in chronic kidney disease. Current Opinion in Nephrology and Hypertension 26 (6), pp.460-466. (10.1097/MNH.0000000000000356)
- Lopez-Anton, M. et al., 2017. miR-21 promotes fibrogenesis in peritoneal dialysis. American Journal of Pathology 187 (7), pp.1537-1550. (10.1016/j.ajpath.2017.03.007)
- Lopez Anton, M. et al. 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164 , pp.37-40. (10.1016/j.mad.2017.03.010)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197 (6), pp.2195-2207. (10.4049/jimmunol.1600990)
- Martin, J. et al. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291 , pp.13789-13801. (10.1074/jbc.M115.670521)
- Simpson, K. et al. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16 (3) 35. (10.1007/s11892-016-0724-8)
- Khalid, U. et al. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30 (2), pp.99-104. (10.1111/ctr.12679)
- Chavez, R. et al. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3 1. (10.7243/2055-091X-3-1)
- Khalid, U. et al. 2015. Urinary microrna expression predicts delayed graft function in kidney transplantation [Abstract]. Transplant International 28 (S4), pp.367-367. (10.1111/tri.12702)
- Beltrami, C. et al., 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1 (2), pp.151-166. (10.3390/ncrna1020151)
- Bowen, T. et al. 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015 427038. (10.1155/2015/427038)
- Jenkins, R. et al. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30 (iii262)(10.1093/ndt/gfv180.15)
- Vigetti, D. et al., 2014. Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation. Journal of Biological Chemistry 289 (42), pp.28816-28826. (10.1074/jbc.M114.597401)
- Khalid, U. et al. 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42 (4), pp.1219-1223. (10.1042/BST20140093)
- Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184 (4), pp.996-1009. (10.1016/j.ajpath.2013.12.028)
- Midgley, A. C. et al. 2014. MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. Aging Cell 13 (2), pp.235-244. (10.1111/acel.12167)
- Benitez, A. et al., 2013. Dietary supplement hymecromone and sorafenib: A novel combination for the control of renal cell carcinoma. The Journal of Urology 190 (1), pp.285-290. (10.1016/j.juro.2012.12.011)
- Bowen, T. , Jenkins, R. H. and Fraser, D. J. 2013. MicroRNAs, transforming growth factor Beta-1, and tissue fibrosis. The Journal of Pathology 229 (2), pp.274-285. (10.1002/path.4119)
- Midgley, A. C. et al. 2013. Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation Is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Journal of Biological Chemistry 288 (21), pp.14824-14838. (10.1074/jbc.M113.451336)
- Beltrami, C. et al. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4), pp.875-879. (10.1042/BST20120090)
- Bowen, T. 2012. A role for fibrocytes in peritoneal fibrosis?. Peritoneal Dialysis International 32 (1), pp.4-6. (10.3747/pdi.2011.00071)
- Jenkins, R. H. et al. 2012. Pleiotropy of microRNA-192 in the kidney. Biochemical Society Transactions 40 (4), pp.762-767. (10.1042/BST20120085)
- Jenkins, R. H. et al. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443 (2), pp.407-416. (10.1042/BJ20111861)
- Michael, D. R. et al. 2011. The human hyaluronan synthase 2 (HAS2) gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell. Journal of Biological Chemistry 286 (22), pp.19523-19532. (10.1074/jbc.M111.233916)
- Martin, J. et al. 2011. Post-transcriptional regulation of transforming growth factor beta-1 by microrna-744. PLoS ONE 6 (10) e25044. (10.1371/journal.pone.0025044)
- Khammas, H. et al. 2011. Characterisation of the human ADAM15 promoter. Nephron Experimental Nephrology 118 (2), pp.e27-e38. (10.1159/000320698)
- Simpson, R. M. L. et al. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175 (5), pp.1915-1928. (10.2353/ajpath.2009.090045)
- Zhang, L. et al. 2009. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction. Journal of Biological Chemistry 284 (39), pp.26447-26455. (10.1074/jbc.M109.003616)
- Nair, S. et al., 2008. Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening. Journal of Nephology 21 (3), pp.400-405.
- Meran, S. et al. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282 (35), pp.25687-25697. (10.1074/jbc.M700773200)
- Saavalainen, K. et al., 2007. Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB. Journal of Biological Chemistry 282 (15), pp.11530-11539. (10.1074/jbc.M607871200)
- Martin, J. , Bowen, T. and Steadman, R. 2006. The pluripotent cytokine pleiotrophin is induced by wounding in human mesangial cells. Kidney International 70 (9), pp.1616-1622. (10.1038/sj.ki.5001800)
- Monslow, J. et al., 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281 (26), pp.18043-18050. (10.1074/jbc.M510467200)
- Bowen, T. et al. 2006. Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells. Journal of the American Society of Nephrology 17 (6), pp.1553-67. (10.1681/ASN.2005080879)
- Rashid Selbi, W. et al. 2006. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. Kidney International 70 (7), pp.1287-1295. (10.1038/sj.ki.5001760)
- Topley, N. , Michael, D. R. and Bowen, T. 2005. CA125: holy grail or a poisoned chalice. Nephron Clinical Practice 100 (2), pp.c52-c54. (10.1159/000085033)
- Monslow, J. et al., 2004. Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 279 (20), pp.20576-20581. (10.1074/jbc.M312666200)
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- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6 (3), pp.259-260. (10.1038/sj.mp.4000128)
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Book sections
- Grigorieva, I. et al. 2023. Hyaluronan in kidney fibrosis. In: Passi, A. ed. Hyaluronan: Structure, Biology and Biotechnology. Vol. 14, Biology of Extracellular Matrix Springer. , pp.77-97. (10.1007/978-3-031-30300-5_5)
Ymchwil
Regulation of gene expression in kidney disease
The central theme of my research group’s work is the regulation of gene expression in kidney disease. This involves understanding how specific deoxyribonucleic acid (DNA) sequences in the human genome, called genes, give rise to functional ribonucleic acid (RNA) and protein products. We translate this knowledge to inform novel approaches to diagnosis, prognosis and treatment of human kidney disease.
Gene products have potential utility as kidney disease biomarkers i.e. sentinels of disease occurrence and/or progression, and may represent targets for therapeutic intervention. In this context, we are interested in functional RNAs including protein coding RNAs, microRNAs and long noncoding RNAs, as well as proteins and the functional molecules that they synthesise e.g. hyaluronan, a glycosaminoglycan of the extracellular matrix.
Current areas of research interest include:
- Analysis of urinary microRNAs as candidate kidney disease biomarkers, and investigation of the functional roles of these microRNAs in renal disease pathology
- Transcriptional regulation of expression of genes encoding products associated with renal disease including selected microRNAs, the human hyaluronan synthases (HASs) and the long noncoding RNA HAS2-AS1, a natural antisense RNA to HAS2
- Post-transcriptional regulation of kidney disease-associated genes by microRNAs and by long noncoding RNAs such as HAS2-AS1
Bywgraffiad
Cyflogaeth
2023-presennol: Athro Bioleg Matrics a Moleciwlaidd, Uned Ymchwil Arennau Cymru (WKRU),
Ysgol Feddygaeth Prifysgol Caerdydd (CUSM)
2020-2023: Darllenydd mewn Bioleg Matrics a Moleciwlaidd, WKRU, CUSM
2011-2020: Uwch Ddarlithydd mewn Bioleg Matrics a Moleciwlaidd, WKRU, CUSM
2001-2011: Darlithydd mewn Bioleg Matrics a Moleciwlaidd, Sefydliad Neffroleg, CUSM
2000-2001: Cydymaith Ymchwil Ôl-ddoethurol (PDRA), Sefydliad Neffroleg, CUSM
1994-2000: PDRA, Adran Meddygaeth Seicolegol, CUSM
1993-1994: PDRA, Adran Geneteg, Prifysgol Caerlŷr
1991-1992: PDRA, Adran Geneteg, Prifysgol Caergrawnt
Addysg
1990: PhD mewn Microbioleg Moleciwlaidd, Prifysgol Dwyrain Llundain (PEL gynt) ac ICI Agrochemicals
1987: BSc mewn Bioleg Gymhwysol, Anrhydedd Dosbarth Cyntaf (CNAA), Polytechnig Dwyrain Llundain (PEL)
Rolau Allanol
Golygydd Cyswllt, Kidney360, 2026 -
Bwrdd Cynghori Arbennig CKM, AstraZeneca, 2026 -
Trysorydd ac Ymddiriedolwr, Cymdeithas Arennau y DU, 2023 -
Cyd-gadeirydd, Wythnos Arennau y DU, 2024 - 2026
Ysgrifennydd, Cymdeithas Ryngwladol Gwyddorau Hyaluronan, 2022 - 2025
Cadeirydd Cyntaf, Pwyllgor Ymchwil Gwyddonwyr Labordy Cymdeithas Arennau y DU, 2020 - 2025
Pwyllgor Grantiau Ymchwil Kidney Research UK, 2019 - 2025
Gwyddonydd Arennol Etholedig, Cyngor Cymdeithas yr Arennau, 2016 - 2020
Pwyllgor Llywio Ansawdd mewn Rhoi Organau (QUOD), 2016 - 2019
VP dros Ymchwil Sylfaenol ac Ymddiriedolwr Dros Dro, Cymdeithas Ryngwladol Gwyddorau Hyaluronan, 2016 - 2020
Pwyllgor Llywodraethu Banc Meinweoedd Ymchwil Arennau Cymru, 2013 -
Gweithgor Gwyddonwyr Arennol y Gymdeithas Arennau, 2013 - 2020
Cynrychiolydd Lleol Cymdeithas Geneteg ar gyfer Ysgol Feddygaeth Prifysgol Caerdydd, 2003 -
Aelodaeth Broffesiynol
Cymdeithas Arennau y DU, 2021 -
Grŵp Astudio Neffropathi Diabetig Ewropeaidd, 2014 -
Cymdeithas Ryngwladol Gwyddorau Hyaluronan, 2006 -
Cymdeithas Biocemegol, 2000 -
Cymdeithas Geneteg, 1992 -
Cymdeithas yr arennau, 2000 - 2021
Cymdeithas Prydain ar gyfer Bioleg Matrics, 2000 - 2019
Cymdeithas Ryngwladol Geneteg Seiciatrig, 1998-2001
Cymdeithas Microbioleg Gyffredinol, 1987-1992
