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Catherine Millson
(hi/ei)
MIScT BSc (Hons)
Rheolwr Data, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
- BresnerCM@caerdydd.ac.uk
- +44 29206 88362
- Adeilad Syr Martin Evans, Ystafell 2.01 - Desk 09, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Trosolwyg
Ar hyn o bryd, rwy'n Rheolwr Data ar gyfer Thema Ymchwil Seicosis yn y Ganolfan Geneteg a Genomeg Niwroseiciatrig. Rwy'n goruchwylio casglu a llywodraethu data o grantiau mawr ac yn rheoli ei guradu a'i ddefnyddio ar brosiectau ymchwil, ac rwy'n gyfrifol am weithredu Cynlluniau Rheoli Data ar gyfer data clinigol, demograffig a genomig. Mae'r rôl hon yn rhoi'r cyfle breintiedig i weithio gydag ef yn uniongyrchol ac mewn cydweithrediad â lluosog Arweinwyr rhyngwladol mewn ymchwil seiciatryddol.
Fy rôl flaenorol oedd yn y Ganolfan Ymchwil Genomeg yn Ysgol y Biowyddorau. Yno roeddwn yn gyfrifol am gynhyrchu data dilyniannu cenhedlaeth nesaf o ansawdd uchel ar gyfer ystod amrywiol o brosiectau o fiofeddygaeth i ecoleg.
Cyn fy swydd gyda Chanolfan Ymchwil Genomeg, roeddwn yn Rheolwr Ymchwil ar gyfer y Grŵp Ymchwil Alzheimer. Roeddwn yn gyfrifol am weithredu'r Tîm Geneteg Clefyd Alzheimer, cynllunio, trefnu a chyflwyno prosiectau o fewn y Brifysgol ac mewn cydweithrediad â gwyddonwyr byd-enwog. Roeddwn hefyd yn gyfrifol am ran helaeth o gyllid ymchwil a rheoli grantiau ac yn darparu cyngor ac arweiniad proffesiynol ar reoli samplau ymchwil a Dynol Prosesau a gweithdrefnau cydymffurfio Deddf Meinweoedd.
Cyn fy rôl reoli, roeddwn yn bennaf mewn labordy ac yn arwain nifer o brosiectau ymchwil labordy ar gyfer Tîm Ymchwil Parkinson's.
Rwy'n aelod o'r Sefydliad Gwyddoniaeth a Thechnoleg ac rwyf wedi derbyn cofrestriad proffesiynol (RSci) gan y Cyngor Gwyddoniaeth.
Cyhoeddiad
2024
- Tan, M. M. X. et al. 2024. Genome-wide determinants of mortality and motor progression in Parkinson’s disease. npj Parkinson's Disease 10(1), article number: 113. (10.1038/s41531-024-00729-8)
- Wu, L. Y. et al. 2024. Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Brain Communications 6(4), article number: fcae190. (10.1093/braincomms/fcae190)
2023
- Real, R. et al. 2023. Association between the LRP1B and APOE loci in the development of Parkinson’s disease dementia. Brain 146(5), pp. 1873-1887. (10.1093/brain/awac414)
- Winchester, L. et al. 2023. Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid. Brain Communications 5(1), article number: fcac343. (10.1093/braincomms/fcac343)
2022
- Willett, B. J. et al. 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7, pp. 1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al. 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22(1), article number: 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12(1), article number: 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al. 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12(1), article number: 10904. (10.1038/s41598-022-14016-0)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
- Aggarwal, D. et al. 2022. Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications 13, article number: 1012. (10.1038/s41467-022-28371-z)
- Aggarwal, D. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications 13(1), article number: 751. (10.1038/s41467-021-27942-w)
2021
- de Rojas, I. et al. 2021. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications 12(1), article number: 3417. (10.1038/s41467-021-22491-8)
- Lythgoe, K. A. et al. 2021. SARS-CoV-2 within-host diversity and transmission. Science 372(6539), article number: eabg0821. (10.1126/science.abg0821)
- Davies, N. G. et al. 2021. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science 372(6538), article number: eabg3055. (10.1126/science.abg3055)
- Tan, M. M. et al. 2021. Genome-wide association studies of cognitive and motor progression in Parkinson's disease. Movement Disorders 36(2), pp. 424-433. (10.1002/mds.28342)
2020
- Alm, E. et al. 2020. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance 25(32), article number: 2001410. (10.2807/1560-7917.ES.2020.25.32.2001410)
2019
- Tan, M. M. et al. 2019. Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study. Brain 142(9), pp. 2828-2844. (10.1093/brain/awz191)
2018
- Malek, N. et al. 2018. Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study. Journal of Neurology, Neurosurgery and Psychiatry 89(7), pp. 702-709. (10.1136/jnnp-2017-317348)
2016
- Malek, N. et al. 2016. Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients. Acta Neurologica Scandinavica 134(4), pp. 271-276. (10.1111/ane.12538)
2015
- Malek, N. et al. 2015. Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease 5(4), pp. 947-959. (10.3233/JPD-150662)
Erthyglau
- Tan, M. M. X. et al. 2024. Genome-wide determinants of mortality and motor progression in Parkinson’s disease. npj Parkinson's Disease 10(1), article number: 113. (10.1038/s41531-024-00729-8)
- Wu, L. Y. et al. 2024. Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Brain Communications 6(4), article number: fcae190. (10.1093/braincomms/fcae190)
- Real, R. et al. 2023. Association between the LRP1B and APOE loci in the development of Parkinson’s disease dementia. Brain 146(5), pp. 1873-1887. (10.1093/brain/awac414)
- Winchester, L. et al. 2023. Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid. Brain Communications 5(1), article number: fcac343. (10.1093/braincomms/fcac343)
- Willett, B. J. et al. 2022. SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology 7, pp. 1161-1179. (10.1038/s41564-022-01143-7)
- Eales, O. et al. 2022. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2. BMC Infectious Diseases 22(1), article number: 647. (10.1186/s12879-022-07628-4)
- Nickbakhsh, S. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning. Scientific Reports 12(1), article number: 11735. (10.1038/s41598-022-15661-1)
- Kläser, K. et al. 2022. COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study. Scientific Reports 12(1), article number: 10904. (10.1038/s41598-022-14016-0)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
- Aggarwal, D. et al. 2022. Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications 13, article number: 1012. (10.1038/s41467-022-28371-z)
- Aggarwal, D. et al. 2022. Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications 13(1), article number: 751. (10.1038/s41467-021-27942-w)
- de Rojas, I. et al. 2021. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications 12(1), article number: 3417. (10.1038/s41467-021-22491-8)
- Lythgoe, K. A. et al. 2021. SARS-CoV-2 within-host diversity and transmission. Science 372(6539), article number: eabg0821. (10.1126/science.abg0821)
- Davies, N. G. et al. 2021. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science 372(6538), article number: eabg3055. (10.1126/science.abg3055)
- Tan, M. M. et al. 2021. Genome-wide association studies of cognitive and motor progression in Parkinson's disease. Movement Disorders 36(2), pp. 424-433. (10.1002/mds.28342)
- Alm, E. et al. 2020. Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020. Eurosurveillance 25(32), article number: 2001410. (10.2807/1560-7917.ES.2020.25.32.2001410)
- Tan, M. M. et al. 2019. Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study. Brain 142(9), pp. 2828-2844. (10.1093/brain/awz191)
- Malek, N. et al. 2018. Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study. Journal of Neurology, Neurosurgery and Psychiatry 89(7), pp. 702-709. (10.1136/jnnp-2017-317348)
- Malek, N. et al. 2016. Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients. Acta Neurologica Scandinavica 134(4), pp. 271-276. (10.1111/ane.12538)
- Malek, N. et al. 2015. Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease 5(4), pp. 947-959. (10.3233/JPD-150662)
Ymchwil
Ar hyn o bryd rwy'n Rheolwr Data ar gyfer Thema Ymchwil Seicosis yn y Ganolfan Geneteg a Genomeg Niwroseiciatrig.
Fy rôl flaenorol yn y Ganolfan Genom yn Ysgol y Biowyddorau yng Nghaerdydd oedd fel uwch dechnegydd, gan gynhyrchu data dilyniannu'r Genhedlaeth Nesaf ar gyfer ystod amrywiol o brosiectau o fiofeddygaeth i ecoleg.
Fel Rheolwr Ymchwil gyda Grŵp Ymchwil Clefyd Alzheimer, roeddwn yn ymwneud â llawer o brosiectau yn ymwneud ag ymchwil Alzheimer a Dementia, ym Mhrifysgol Caerdydd a hefyd cydweithrediadau rhyngwladol mawr.
Cyn fy rôl reoli, ymchwiliodd fy mhrosiectau ymchwil i sylfaen genetig clefyd Parkinson, lle defnyddiais ystod amrywiol o dechnegau cymhleth er mwyn cynhyrchu data biolegol o ansawdd uchel a ddefnyddir wedyn ar gyfer dadansoddi ystadegol.
Bywgraffiad
2024 - Yn bresennol: Rheolwr Data, Grŵp Ymchwil Seicosis, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
2020 - 2024 Uwch Dechnegydd (Hwb Ymchwil Genom), Ysgol y Biowyddorau.
2019 - 2020: Rheolwr Ymchwil, Grŵp Ymchwil Alzheimer, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
2018 - 2019: Cydlynydd Sampl, Grŵp Ymchwil Alzheimer, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
2012 - 2018: Uwch Dechnegydd Ymchwil, Grŵp Ymchwil Parkinson, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
2010 - 2012: Technegydd Ymchwil, Cyfleuster Craidd, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
Anrhydeddau a dyfarniadau
Gwyddonydd Cofrestredig (RSci), a ddyfarnwyd gan y Cyngor Gwyddoniaeth (2018)
Aelodaethau proffesiynol
Aelod o'r Sefydliad Gwyddoniaeth a Thechnoleg
Themâu ymchwil
Arbenigeddau
- Epigeneteg
- Epigenomeg
- Geneteg
- Methylu genomau
- Rheoli data