![Niek Buurma](https://profiles-cardiff.imgix.net/attachments/1469?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Niek Buurma
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Niek Buurma
Uwch Ddarlithydd mewn Cemeg Organig Gorfforol
Trosolwyg
Magwyd Niek yn yr Iseldiroedd, wedi'i amgylchynu gan ddŵr, ac felly nid yw'n syndod bod ymchwil yn ein grŵp wedi'i anelu at ddeall adweithiau a rhyngweithiadau mewn datrysiadau dyfrllyd. Mae ein hymchwil yn canolbwyntio ar ddau brif faes.
Y maes cyntaf yw datblygu rhwymwyr DNA cyfunol gyda phriodweddau optoelectronig defnyddiol i'w defnyddio fel sensitifyddion mewn diagnosteg moleciwlaidd a biosynwyryddion, i'w defnyddio mewn fforensig, yn ogystal ag i'w defnyddio mewn systemau nanobioelectronig hunan-ymgynnull. Mae ein cyfraniadau i'r maes hwn yn cynnwys synthesis cyfansoddion rhwymo DNA newydd ac astudiaethau o'u priodweddau rhwymo DNA gan ddefnyddio amrywiaeth o dechnegau bioffisegol. Er mwyn cefnogi'r astudiaethau hyn, rydym hefyd yn datblygu meddalwedd dadansoddi data, yn enwedig meddalwedd ar gyfer dadansoddi data calorimetreg titration isothermal (ITC) ar gyfer cydbwysedd cymhleth.
Mae'r ail faes o ddiddordeb yn cynnwys astudio adweithiau organig mewn toddiannau dyfrllyd. Rydym yn canolbwyntio ar 1) prosesau hileiddio fferyllol perthnasol, 2) astudiaethau cinetig a mecanyddol o adweithiau wedi'u cataleiddio gan fetel gyda chymorth syrffactydd, yn ogystal ag adweithiau wedi'u cataleiddio gan nanoronynnau, 3) astudiaethau adweithedd gan ddefnyddio optimeiddio adwaith awtomataidd yn seiliedig ar ddeallusrwydd artiffisial (AI), 4) effeithiau cyfrwng micellar a 5) cineteg diraddio fferyllol gan gynnwys yn yr amgylchedd.
Mae'r grŵp yn ymwneud â chydweithrediadau rhyngwladol yn ogystal â chydweithrediadau â diwydiant.
Mae Niek yn weithgar ym maes allgymorth gwyddoniaeth ac mae wedi cyflwyno prosiectau ymchwil y grŵp yn Pint of Science yn 2017, 2018 a 2019). Mae ein gwaith ar hilio wedi ymddangos ar BBC News.
Am ragor o wybodaeth, cliciwch ar y tab 'Ymchwil' uchod.
Cyhoeddiad
2025
- Rainbow, J., Judd-Cooper, E. P., Pope, S. J. A., Buurma, N. J. and Estrela, P. 2025. Electrochemical signal amplification for pathogen nucleic acid detection utilizing a cobalt-based DNA-binding metallo-intercalator. Sensors & Diagnostics 4(6), pp. 519-528. (10.1039/D4SD00322E)
- Alkhaibari, I., Horton, P. N., Coles, S. J., Buurma, N. J. and Pope, S. J. 2025. DNA‐binding properties of non‐intercalating water‐soluble organometallic Ir(III) luminophores. Chemistry - A European Journal 31(30), article number: e202500290. (10.1002/chem.202500290)
2024
- Alkhaibari, I. S. et al. 2024. Tuning excited state character in iridium(III) photosensitizers and its influence on TTA-UC. Inorganic Chemistry 63(21), pp. 9931-9940. (10.1021/acs.inorgchem.4c01003)
2023
- Buurma, N. J. and Bagley, S. W. 2023. A focus on computer vision for non-contact monitoring of catalyst degradation and product formation kinetics. Chemical Science 14(40), pp. 10994-10996. (10.1039/d3sc90145a)
- Pritchard, M. F. et al. 2023. Structure–activity relationships of low molecular weight alginate oligosaccharide therapy against Pseudomonas aeruginosa. Biomolecules 13(9), article number: 1366. (10.3390/biom13091366)
2022
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
2021
- Dasgupta, A. et al. 2021. Site-selective Csp3–Csp/Csp3–Csp2 cross-coupling reactions using frustrated Lewis pairs. Journal of the American Chemical Society 143(11), pp. 4451-4464. (10.1021/jacs.1c01622)
2020
- Day, A. H. et al. 2020. Targeted cell imaging properties of a deep red luminescent iridium(III) complex conjugated with a c-Myc signal peptide. Chemical Science 11(6), pp. 1599-1606. (10.1039/C9SC05568A)
2019
- Ballard, A. et al. 2019. Racemisation in chemistry and biology. Chemistry - A European Journal (10.1002/chem.201903917)
- Saeed, I. Q. and Buurma, N. J. 2019. Analysis of isothermal titration calorimetry data for complex interactions using I2CITC. In: Ennifar, E. ed. Microcalorimetry of Biological Molecules., Vol. 1964. Methods in Molecular Biology Humana Press, pp. 169-183., (10.1007/978-1-4939-9179-2_13)
- Ballard, A., Narduolo, S., Ahmad, H. O., Cosgrove, D. A., Leach, A. G. and Buurma, N. J. 2019. The problem of racemization in drug discovery and tools to predict it. Expert Opinion on Drug Discovery 14(6), pp. 527-539. (10.1080/17460441.2019.1588881)
2018
- Powell, L. C. et al. 2018. Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes 4, article number: 13. (10.1038/s41522-018-0056-3)
- Ballard, A. et al. 2018. Quantitative prediction of rate constants for aqueous racemization to avoid pointless stereoselective syntheses. Angewandte Chemie International Edition 57(4), pp. 982-985. (10.1002/anie.201709163)
2017
- Buurma, N. J. 2017. Aggregation and reactivity in aqueous solutions of cationic surfactants and aromatic anions across concentration scales. Current Opinion in Colloid & Interface Science 32, pp. 69-75. (10.1016/j.cocis.2017.10.005)
- Saeed, H. K. et al. 2017. Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical, and biological studies. Angewandte Chemie International Edition 56(41), pp. 12628-12633. (10.1002/anie.201707350)
- Bouleghlimat, A., Othman, M., Lagrave, L., Matsuzawa, S., Nakamura, Y., Fujii, S. and Buurma, N. 2017. Halide-enhanced catalytic activity of palladium nanoparticles comes at the expense of catalyst recovery. Catalysts 7(9), article number: 280. (10.3390/catal7090280)
- Buurma, N. J. 2017. π-conjugated DNA binders. In: Stulz, E. and Clever, G. H. eds. Supramolecular Chemistry and Nanotechnology. Wiley, pp. ch1.2., (10.1002/9781118696880.ch1.2)
- Saeed, H., Saeed, I., Buurma, N. and Thomas, J. A. 2017. The structure of linkers affects the DNA binding properties of tethered dinuclear ruthenium (II) metallo-intercalators. Chemistry - A European Journal 23(23), pp. 5467 -5477. (10.1002/chem.201605750)
- Pritchard, M. F. et al. 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports 7, article number: 44731. (10.1038/srep44731)
- Cao, T., Zhang, F., Cai, L., Zhou, Y., Buurma, N. J. and Zhang, X. 2017. Investigation of the interactions between methylene blue and intramolecular G-quadruplexes: an explicit distinction in electrochemical behavior. Analyst 2017(142), pp. 987-993. (10.1039/C7AN00083A)
2016
- Hahn, L., Buurma, N. J. and Gade, L. H. 2016. A water-soluble tetraazaperopyrene dye as strong G-quadruplex DNA binder. Chemistry - A European Journal 22(18), pp. 6314-6322. (10.1002/chem.201504934)
2015
- Burley, G. A. et al. 2015. (Non-) covalently modified DNA with novel functions. In: Stults, E. and Clever, G. eds. DNA in Supramolecular Chemistry and Nanotechnology. UK: Wiley-Blackwell, pp. 1-15., (10.1002/9781118696880.ch1)
2014
- Zheng, G. et al. 2014. Palladium nanoparticle-loaded cellulose paper: a highly efficient, robust, and recyclable self-assembled composite catalytic system. The Journal of Physical Chemistry Letters 6(2), pp. 230-238. (10.1021/jz5024948)
- Regan, E. M. et al. 2014. A novel cobalt complex for enhancing amperometric and impedimetric DNA detection. Electrochimica Acta 128, pp. 10-15. (10.1016/j.electacta.2013.10.028)
2013
- Salvia, M. et al. 2013. Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove. Biophysical Chemistry 179, pp. 1-11. (10.1016/j.bpc.2013.04.001)
- Postolachi, R., Danac, R., Buurma, N. J., Pui, A., Balan, M., Shova, S. and Deleanu, C. 2013. New cycloimmonium ylide ligands and their palladium(ii) affinities. RSC Advances 3(38), pp. 17260-17270. (10.1039/c3ra41911h)
- Dávila-Ibáñez, A. B., Buurma, N. J. and Salgueiriño, V. 2013. Assessment of DNA complexation onto polyelectrolyte-coated magnetic silica nanoparticles. Nanoscale 5(11), pp. 4797-4807. (10.1039/c3nr34358h)
2012
- Buurma, N. J. 2012. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 108, pp. 316-333. (10.1039/c2oc90021a)
- Leach, A. G. et al. 2012. Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain. MedChemComm 3(5), pp. 528-540. (10.1039/c2md20010d)
- Fujii, S., Matsuzawa, S., Hamasaki, H., Nakamura, Y., Bouleghlimat, A. and Buurma, N. J. 2012. Polypyrrole-palladium nanocomposite coating of micrometer-sized polymer particles toward a recyclable catalyst. Langmuir 28(5), pp. 2436-2447. (10.1021/la204324f)
- Saad, F., Buurma, N. J., Amoroso, A. J., Knight, J. C. and Kariuki, B. . 2012. Co-ordination behaviour of a novel bisthiourea tripodal ligand: structural, spectroscopic and electrochemical properties of a series of transition metal complexes. Dalton Transactions 41(15), pp. 4608-4617. (10.1039/c2dt11732k)
2011
- Taladriz Blanco, P., Buurma, N. J., Rodriguez Lorenzo, L., Perez Juste, J., Liz Marzan, L. and Herves, P. 2011. Reversible assembly of metal nanoparticles induced by penicillamine. Dynamic formation of SERS hot spots. Journal of Materials Chemistry 21(42), pp. 16880-16887. (10.1039/C1JM12175H)
- Buurma, N. J. 2011. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 107, pp. 328-348. (10.1039/c1oc90014e)
- Onel, L. and Buurma, N. J. 2011. The Nature of the Sodium Dodecylsulfate Micellar Pseudophase as Studied by Reaction Kinetics. Journal of Physical Chemistry B 115(45), pp. 13199-13211. (10.1021/jp208171w)
- Jones, J. E., Amoroso, A. J., Dorin, I. M., Parigi, G., Ward, B. D., Buurma, N. J. and Pope, S. J. A. 2011. Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity. Chemical Communications 47(12), pp. 3374-3376. (10.1039/C1CC00111F)
2010
- Buurma, N. J., Cook, J. L., Hunter, C. A., Low, C. M. R. and Vinter, J. G. 2010. The role of functional group concentration in solvation thermodynamics. Chemical Science 1(2), pp. 242-246. (10.1039/C0SC00209G)
- Wheelhouse, R. T., Garbett, N. C., Buurma, N. J. and Chaires, J. B. 2010. Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition 49(18), pp. 3207-3210. (10.1002/anie.200907235)
- Carregal-Romero, S., Buurma, N. J., Pérez-Juste, J., Liz-Marzán, L. M. and Hervés, P. 2010. Catalysis by Au@pNIPAM nanocomposites: effect of the cross-linking density. Chemistry of Materials 22(10), pp. 3051-3059. (10.1021/cm903261b)
- Onel, L. and Buurma, N. J. 2010. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 106, pp. 344-375. (10.1039/b927079p)
2009
- Onel, L. and Buurma, N. J. 2009. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 105, pp. 363-379. (10.1039/b905116n)
- Buurma, N. J. 2009. Kinetic medium effects on organic reactions in aqueous colloidal solutions. Advances in Physical Organic Chemistry 43, pp. 1-37. (10.1016/S0065-3160(08)00001-4)
2008
- Buurma, N. J. and Haq, I. 2008. Calorimetric and spectroscopic studies of Hoechst 33258: self-association and binding to non-cognate DNA. Journal of Molecular Biology 381(3), pp. 607-621. (10.1016/j.jmb.2008.05.073)
- Spillane, C. B., Dabo, M. N., Fletcher, N. C., Morgan, J. L., Keene, F. R., Haq, I. and Buurma, N. J. 2008. The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups. Journal of Inorganic Biochemistry 102(4), pp. 673-683. (10.1016/j.jinorgbio.2007.10.011)
- Mullice, L. A., Laye, R. H., Harding, L. P., Buurma, N. J. and Pope, S. J. A. 2008. Rhenium complexes of chromophore-appended dipicolylamine ligands: syntheses, spectroscopic properties, DNA binding and X-ray crystal structure. New Journal of Chemistry 32(12), pp. 2140-2149. (10.1039/b800999f)
2006
- Shibata, T., Buurma, N. J., Brazier, J. A., Thompson, P., Haq, I. and Williams, D. M. 2006. 7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes. Chemical Communications(33), pp. 3516-3518. (10.1039/b606058g)
2004
- Buurma, N. J., Serena, P., Blandamer, M. J. and Engberts, J. B. F. N. 2004. The Nature of the Micellar Stern Region As Studied by Reaction Kinetics. 2. The Journal of Organic Chemistry 69(11), pp. 3899-3906. (10.1021/jo049959l)
2003
- Buurma, N. J., Blandamer, M. J. and Engberts, J. B. F. N. 2003. General-base catalysed hydrolysis and nucleophilic substitution of activated amides in aqueous solutions. Journal of Physical Organic Chemistry 16(8), pp. 438-449. (10.1002/poc.607)
2001
- Buurma, N. J., Pastorello, L., Blandamer, M. J. and Engberts, J. B. F. N. 2001. Kinetic Evidence for Hydrophobically Stabilized Encounter Complexes Formed by Hydrophobic Esters in Aqueous Solutions Containing Monohydric Alcohols. Journal of the American Chemical Society 123(48), pp. 11848-11853. (10.1021/ja010617w)
Articles
- Rainbow, J., Judd-Cooper, E. P., Pope, S. J. A., Buurma, N. J. and Estrela, P. 2025. Electrochemical signal amplification for pathogen nucleic acid detection utilizing a cobalt-based DNA-binding metallo-intercalator. Sensors & Diagnostics 4(6), pp. 519-528. (10.1039/D4SD00322E)
- Alkhaibari, I., Horton, P. N., Coles, S. J., Buurma, N. J. and Pope, S. J. 2025. DNA‐binding properties of non‐intercalating water‐soluble organometallic Ir(III) luminophores. Chemistry - A European Journal 31(30), article number: e202500290. (10.1002/chem.202500290)
- Alkhaibari, I. S. et al. 2024. Tuning excited state character in iridium(III) photosensitizers and its influence on TTA-UC. Inorganic Chemistry 63(21), pp. 9931-9940. (10.1021/acs.inorgchem.4c01003)
- Buurma, N. J. and Bagley, S. W. 2023. A focus on computer vision for non-contact monitoring of catalyst degradation and product formation kinetics. Chemical Science 14(40), pp. 10994-10996. (10.1039/d3sc90145a)
- Pritchard, M. F. et al. 2023. Structure–activity relationships of low molecular weight alginate oligosaccharide therapy against Pseudomonas aeruginosa. Biomolecules 13(9), article number: 1366. (10.3390/biom13091366)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Dasgupta, A. et al. 2021. Site-selective Csp3–Csp/Csp3–Csp2 cross-coupling reactions using frustrated Lewis pairs. Journal of the American Chemical Society 143(11), pp. 4451-4464. (10.1021/jacs.1c01622)
- Day, A. H. et al. 2020. Targeted cell imaging properties of a deep red luminescent iridium(III) complex conjugated with a c-Myc signal peptide. Chemical Science 11(6), pp. 1599-1606. (10.1039/C9SC05568A)
- Ballard, A. et al. 2019. Racemisation in chemistry and biology. Chemistry - A European Journal (10.1002/chem.201903917)
- Ballard, A., Narduolo, S., Ahmad, H. O., Cosgrove, D. A., Leach, A. G. and Buurma, N. J. 2019. The problem of racemization in drug discovery and tools to predict it. Expert Opinion on Drug Discovery 14(6), pp. 527-539. (10.1080/17460441.2019.1588881)
- Powell, L. C. et al. 2018. Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes 4, article number: 13. (10.1038/s41522-018-0056-3)
- Ballard, A. et al. 2018. Quantitative prediction of rate constants for aqueous racemization to avoid pointless stereoselective syntheses. Angewandte Chemie International Edition 57(4), pp. 982-985. (10.1002/anie.201709163)
- Buurma, N. J. 2017. Aggregation and reactivity in aqueous solutions of cationic surfactants and aromatic anions across concentration scales. Current Opinion in Colloid & Interface Science 32, pp. 69-75. (10.1016/j.cocis.2017.10.005)
- Saeed, H. K. et al. 2017. Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical, and biological studies. Angewandte Chemie International Edition 56(41), pp. 12628-12633. (10.1002/anie.201707350)
- Bouleghlimat, A., Othman, M., Lagrave, L., Matsuzawa, S., Nakamura, Y., Fujii, S. and Buurma, N. 2017. Halide-enhanced catalytic activity of palladium nanoparticles comes at the expense of catalyst recovery. Catalysts 7(9), article number: 280. (10.3390/catal7090280)
- Saeed, H., Saeed, I., Buurma, N. and Thomas, J. A. 2017. The structure of linkers affects the DNA binding properties of tethered dinuclear ruthenium (II) metallo-intercalators. Chemistry - A European Journal 23(23), pp. 5467 -5477. (10.1002/chem.201605750)
- Pritchard, M. F. et al. 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports 7, article number: 44731. (10.1038/srep44731)
- Cao, T., Zhang, F., Cai, L., Zhou, Y., Buurma, N. J. and Zhang, X. 2017. Investigation of the interactions between methylene blue and intramolecular G-quadruplexes: an explicit distinction in electrochemical behavior. Analyst 2017(142), pp. 987-993. (10.1039/C7AN00083A)
- Hahn, L., Buurma, N. J. and Gade, L. H. 2016. A water-soluble tetraazaperopyrene dye as strong G-quadruplex DNA binder. Chemistry - A European Journal 22(18), pp. 6314-6322. (10.1002/chem.201504934)
- Zheng, G. et al. 2014. Palladium nanoparticle-loaded cellulose paper: a highly efficient, robust, and recyclable self-assembled composite catalytic system. The Journal of Physical Chemistry Letters 6(2), pp. 230-238. (10.1021/jz5024948)
- Regan, E. M. et al. 2014. A novel cobalt complex for enhancing amperometric and impedimetric DNA detection. Electrochimica Acta 128, pp. 10-15. (10.1016/j.electacta.2013.10.028)
- Salvia, M. et al. 2013. Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove. Biophysical Chemistry 179, pp. 1-11. (10.1016/j.bpc.2013.04.001)
- Postolachi, R., Danac, R., Buurma, N. J., Pui, A., Balan, M., Shova, S. and Deleanu, C. 2013. New cycloimmonium ylide ligands and their palladium(ii) affinities. RSC Advances 3(38), pp. 17260-17270. (10.1039/c3ra41911h)
- Dávila-Ibáñez, A. B., Buurma, N. J. and Salgueiriño, V. 2013. Assessment of DNA complexation onto polyelectrolyte-coated magnetic silica nanoparticles. Nanoscale 5(11), pp. 4797-4807. (10.1039/c3nr34358h)
- Buurma, N. J. 2012. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 108, pp. 316-333. (10.1039/c2oc90021a)
- Leach, A. G. et al. 2012. Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain. MedChemComm 3(5), pp. 528-540. (10.1039/c2md20010d)
- Fujii, S., Matsuzawa, S., Hamasaki, H., Nakamura, Y., Bouleghlimat, A. and Buurma, N. J. 2012. Polypyrrole-palladium nanocomposite coating of micrometer-sized polymer particles toward a recyclable catalyst. Langmuir 28(5), pp. 2436-2447. (10.1021/la204324f)
- Saad, F., Buurma, N. J., Amoroso, A. J., Knight, J. C. and Kariuki, B. . 2012. Co-ordination behaviour of a novel bisthiourea tripodal ligand: structural, spectroscopic and electrochemical properties of a series of transition metal complexes. Dalton Transactions 41(15), pp. 4608-4617. (10.1039/c2dt11732k)
- Taladriz Blanco, P., Buurma, N. J., Rodriguez Lorenzo, L., Perez Juste, J., Liz Marzan, L. and Herves, P. 2011. Reversible assembly of metal nanoparticles induced by penicillamine. Dynamic formation of SERS hot spots. Journal of Materials Chemistry 21(42), pp. 16880-16887. (10.1039/C1JM12175H)
- Buurma, N. J. 2011. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 107, pp. 328-348. (10.1039/c1oc90014e)
- Onel, L. and Buurma, N. J. 2011. The Nature of the Sodium Dodecylsulfate Micellar Pseudophase as Studied by Reaction Kinetics. Journal of Physical Chemistry B 115(45), pp. 13199-13211. (10.1021/jp208171w)
- Jones, J. E., Amoroso, A. J., Dorin, I. M., Parigi, G., Ward, B. D., Buurma, N. J. and Pope, S. J. A. 2011. Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity. Chemical Communications 47(12), pp. 3374-3376. (10.1039/C1CC00111F)
- Buurma, N. J., Cook, J. L., Hunter, C. A., Low, C. M. R. and Vinter, J. G. 2010. The role of functional group concentration in solvation thermodynamics. Chemical Science 1(2), pp. 242-246. (10.1039/C0SC00209G)
- Wheelhouse, R. T., Garbett, N. C., Buurma, N. J. and Chaires, J. B. 2010. Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition 49(18), pp. 3207-3210. (10.1002/anie.200907235)
- Carregal-Romero, S., Buurma, N. J., Pérez-Juste, J., Liz-Marzán, L. M. and Hervés, P. 2010. Catalysis by Au@pNIPAM nanocomposites: effect of the cross-linking density. Chemistry of Materials 22(10), pp. 3051-3059. (10.1021/cm903261b)
- Onel, L. and Buurma, N. J. 2010. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 106, pp. 344-375. (10.1039/b927079p)
- Onel, L. and Buurma, N. J. 2009. Reactivity in organised assemblies. Annual Reports Section "B" (Organic Chemistry) 105, pp. 363-379. (10.1039/b905116n)
- Buurma, N. J. 2009. Kinetic medium effects on organic reactions in aqueous colloidal solutions. Advances in Physical Organic Chemistry 43, pp. 1-37. (10.1016/S0065-3160(08)00001-4)
- Buurma, N. J. and Haq, I. 2008. Calorimetric and spectroscopic studies of Hoechst 33258: self-association and binding to non-cognate DNA. Journal of Molecular Biology 381(3), pp. 607-621. (10.1016/j.jmb.2008.05.073)
- Spillane, C. B., Dabo, M. N., Fletcher, N. C., Morgan, J. L., Keene, F. R., Haq, I. and Buurma, N. J. 2008. The dichotomy in the DNA-binding behaviour of ruthenium(II) complexes bearing benzoxazole and benzothiazole groups. Journal of Inorganic Biochemistry 102(4), pp. 673-683. (10.1016/j.jinorgbio.2007.10.011)
- Mullice, L. A., Laye, R. H., Harding, L. P., Buurma, N. J. and Pope, S. J. A. 2008. Rhenium complexes of chromophore-appended dipicolylamine ligands: syntheses, spectroscopic properties, DNA binding and X-ray crystal structure. New Journal of Chemistry 32(12), pp. 2140-2149. (10.1039/b800999f)
- Shibata, T., Buurma, N. J., Brazier, J. A., Thompson, P., Haq, I. and Williams, D. M. 2006. 7,8-Dihydropyrido[2,3-d]pyrimidin-2-one; a bicyclic cytosine analogue capable of enhanced stabilisation of DNA duplexes. Chemical Communications(33), pp. 3516-3518. (10.1039/b606058g)
- Buurma, N. J., Serena, P., Blandamer, M. J. and Engberts, J. B. F. N. 2004. The Nature of the Micellar Stern Region As Studied by Reaction Kinetics. 2. The Journal of Organic Chemistry 69(11), pp. 3899-3906. (10.1021/jo049959l)
- Buurma, N. J., Blandamer, M. J. and Engberts, J. B. F. N. 2003. General-base catalysed hydrolysis and nucleophilic substitution of activated amides in aqueous solutions. Journal of Physical Organic Chemistry 16(8), pp. 438-449. (10.1002/poc.607)
- Buurma, N. J., Pastorello, L., Blandamer, M. J. and Engberts, J. B. F. N. 2001. Kinetic Evidence for Hydrophobically Stabilized Encounter Complexes Formed by Hydrophobic Esters in Aqueous Solutions Containing Monohydric Alcohols. Journal of the American Chemical Society 123(48), pp. 11848-11853. (10.1021/ja010617w)
Book sections
- Saeed, I. Q. and Buurma, N. J. 2019. Analysis of isothermal titration calorimetry data for complex interactions using I2CITC. In: Ennifar, E. ed. Microcalorimetry of Biological Molecules., Vol. 1964. Methods in Molecular Biology Humana Press, pp. 169-183., (10.1007/978-1-4939-9179-2_13)
- Buurma, N. J. 2017. π-conjugated DNA binders. In: Stulz, E. and Clever, G. H. eds. Supramolecular Chemistry and Nanotechnology. Wiley, pp. ch1.2., (10.1002/9781118696880.ch1.2)
- Burley, G. A. et al. 2015. (Non-) covalently modified DNA with novel functions. In: Stults, E. and Clever, G. eds. DNA in Supramolecular Chemistry and Nanotechnology. UK: Wiley-Blackwell, pp. 1-15., (10.1002/9781118696880.ch1)
- Taladriz Blanco, P., Buurma, N. J., Rodriguez Lorenzo, L., Perez Juste, J., Liz Marzan, L. and Herves, P. 2011. Reversible assembly of metal nanoparticles induced by penicillamine. Dynamic formation of SERS hot spots. Journal of Materials Chemistry 21(42), pp. 16880-16887. (10.1039/C1JM12175H)
- Onel, L. and Buurma, N. J. 2011. The Nature of the Sodium Dodecylsulfate Micellar Pseudophase as Studied by Reaction Kinetics. Journal of Physical Chemistry B 115(45), pp. 13199-13211. (10.1021/jp208171w)
- Jones, J. E., Amoroso, A. J., Dorin, I. M., Parigi, G., Ward, B. D., Buurma, N. J. and Pope, S. J. A. 2011. Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity. Chemical Communications 47(12), pp. 3374-3376. (10.1039/C1CC00111F)
- Buurma, N. J., Cook, J. L., Hunter, C. A., Low, C. M. R. and Vinter, J. G. 2010. The role of functional group concentration in solvation thermodynamics. Chemical Science 1(2), pp. 242-246. (10.1039/C0SC00209G)
- Wheelhouse, R. T., Garbett, N. C., Buurma, N. J. and Chaires, J. B. 2010. Probing the molecular recognition of a DNA-RNA hybrid duplex. Angewandte Chemie International Edition 49(18), pp. 3207-3210. (10.1002/anie.200907235)
- Carregal-Romero, S., Buurma, N. J., Pérez-Juste, J., Liz-Marzán, L. M. and Hervés, P. 2010. Catalysis by Au@pNIPAM nanocomposites: effect of the cross-linking density. Chemistry of Materials 22(10), pp. 3051-3059. (10.1021/cm903261b)
- Buurma, N. J. and Haq, I. 2008. Calorimetric and spectroscopic studies of Hoechst 33258: self-association and binding to non-cognate DNA. Journal of Molecular Biology 381(3), pp. 607-621. (10.1016/j.jmb.2008.05.073)
Ymchwil
Mae'r ddau brif faes ymchwil yn y grŵp (datblygu rhwymwyr DNA cyfunol ac astudio adweithiau organig mewn toddiannau dyfrllyd) yn cwmpasu sawl prosiect cysylltiedig.
Targedu DNA
Mae DNA yn darged pwysig ar gyfer cyffuriau a genosynwyryddion posibl. Mae moleciwlau sy'n caniatáu rheolaeth dros ddetholusrwydd ac affinedd at DNA felly o ddiddordeb arbennig fel genosynwyryddion (a/neu asiantau therapiwtig). Rydym yn datblygu motiffau rhwymo DNA newydd sy'n cynnwys systemau cyfunol llawn sy'n arddangos newidiadau mewn priodweddau optoelectronig wrth ryngweithio â DNA mewn cydweithrediad â'r Athro Simon Pope. Mae'r moleciwlau hyn yn cael eu defnyddio fel sensitifyddion mewn biosynwyryddion sy'n canfod presenoldeb pathogenau bacteriol trwy ganfod eu dilyniannau DNA unigryw. Yn y synwyryddion hyn, amlygir ffurfio helix dwbl rhwng llinyn cipio a llinyn targed oherwydd bod y sensitifyddion yn rhwymo i'r DNA deublyg a ffurfiwyd.
Yn yr un modd, gellir defnyddio moleciwlau sy'n targedu DNA mewn cymwysiadau mewn fforensig. Rydym yn datblygu llifynnau ar gyfer canfod tystiolaeth olrhain biolegol yn hawdd ac yn ddiogel mewn lleoliadau trosedd, heb ddiraddio'r dystiolaeth yn y broses. Rydym wedi nodi sawl cyfansoddyn o ddiddordeb yr ydym yn eu profi gan ddefnyddio dulliau cemeg ffisegol mewn modelau o leoliadau trosedd i asesu sensitifrwydd a detholusrwydd.
Ar wahân i fod yn darged diddorol ar gyfer cymwysiadau biofeddygol a fforensig, mae DNA ynddo'i hun yn ffurfio bloc adeiladu amlbwrpas ar gyfer ystod o strwythurau 3D. Mae cyfuno'r strwythurau 3D hyn â moleciwlau rhwymo DNA sydd â phriodweddau electronig diddorol yn agor byd nanobioelectroneg. Yn y maes hwn, rydym yn datblygu dulliau newydd a thechnegau dadansoddol i nodi'r blociau adeiladu ar gyfer nanostrwythurau swyddogaethol hunan-ymgynnull.
Am drosolwg o'r cymwysiadau hyn, gweler ein pennod llyfr yn "DNA in Supramolecular Chemistry and Nanotechnology".
Adweithedd organig mewn toddiannau dyfrllyd
Mae ein diddordeb mewn adweithedd organig yn canolbwyntio ar atebion dyfrllyd.
Mae astudiaethau cinetig a mecanyddol o adweithiau racemization mewn datrysiadau dyfrllyd yn un o'n meysydd diddordeb allweddol. Er gwaethaf diddordeb aruthrol mewn synthesis enantioselective, roedd y maes o sefydlogrwydd chiral wedi cael ei anwybyddu ers degawdau. O ganlyniad, mae adnoddau sylweddol yn cael eu gwario ar synthesis enantioselective o ganolfannau stereogenig di-bwrpas, h.y. canolfannau stereogenig a fydd yn rasio'n gyflym pan gaiff eu defnyddio mewn atebion biolegol berthnasol. Rydym wedi datblygu'r rhagfynegiad meintiol cyntaf o risg racemization gyda chymhwysedd cyffredinol. Mae'r dull rhagfynegol hwn yn caniatáu i ymchwilwyr mewn diwydiant a'r byd academaidd osgoi canolfannau stereogenig ansefydlog ac fe'i cyhoeddwyd fel "Papur Poeth" yn Angewandte Chemie . Mae gan yr ymchwil hon gymwysiadau amlwg mewn cemeg feddyginiaethol a thu hwnt.
Rydym hefyd yn cymhwyso ein dealltwriaeth o effeithiau cyfrwng adwaith mewn datrysiadau dyfrllyd wrth ddatblygu adweithiau metel pontio gan ddefnyddio cymhlethdodau moleciwlaidd a nanoronynnau fel catalyddion. Mae gennym ddiddordeb mewn astudiaethau mecanyddol o brosesau pylu ffotocemegol ac rydym yn cynnal astudiaethau o'r fath mewn cydweithrediad â grŵp Dr Joe Beames.
Yn olaf, rydym yn cymhwyso ein dulliau cinetig i astudio diraddio fferyllol mewn systemau sy'n dynwared yr amgylchedd, gyda chyfieithu i systemau amgylcheddol gwirioneddol mewn cydweithrediad â Dr Ben Ward
Datblygu model a dulliau
Mae ein hymchwil yn aml yn gofyn am ddatblygu modelau mathemategol newydd neu ddatblygu technegau arbrofol newydd.
Un o'r technegau a ddefnyddir ar gyfer astudio rhyngweithiadau â DNA a (bio)macromoleciwlau eraill yw calorimetreg titration isothermol (ITC). Rydym yn datblygu meddalwedd dadansoddi data ar gyfer cydbwysedd cymhleth (cypl). Mae ein meddalwedd yn cyfuno cyfuniad modiwlaidd o brosesau rhyngweithio, algorithmau optimeiddio o ddeallusrwydd artiffisial, a dadansoddiad dilysrwydd paramedr ôl-ffitio pwerus. Mae'r cyfuniad hwn yn sicrhau hyblygrwydd mwyaf posibl wrth ddadansoddi data tra'n cadw paramedrau ystadegol arwyddocaol. Mae ein meddalwedd yn cael ei ddefnyddio ledled y byd ac yn aml yn sail i gydweithredu â'r byd academaidd a diwydiant.
Mae ein hastudiaethau o adweithiau a rhyngweithiadau hefyd yn gofyn am ddatblygu modelau mathemategol ar gyfer dadansoddi data arbrofol. Er enghraifft, yn ogystal â'n meddalwedd ar gyfer dadansoddi data ITC cymhleth, rydym wedi datblygu modelau ar gyfer dadansoddiad byd-eang o cineteg ensymau sy'n dibynnu ar pH a thymheredd, ar gyfer dadansoddi data cinetig ar gyfer catalysis gan nanoronynnau aur wedi'u crynhoi o fewn cragen thermosensitif, ac ar gyfer rhwymo metelau ar y cyd i systemau lletyol deuvalent.
Oherwydd yr angen am ddata meintiol, mae llawer o'n hymchwil hefyd yn cael ei gefnogi gan gemeg ddadansoddol. Mae defnyddio technegau dadansoddol presennol a datblygu technegau newydd felly hefyd yn bwysig.
Mae rhan sylweddol o'r gwaith hwn mewn cydweithrediad â'r Sefydliad Darganfod Meddyginiaethau
Deallusrwydd artiffisial mewn cemeg
Mae'r grŵp wedi datblygu meddalwedd dadansoddi data ers ymhell dros ddegawd. Mae'r algorithmau deallusrwydd artiffisial a ddefnyddir mewn dadansoddi data hefyd yn cynnig potensial mewn optimeiddio adweithiau. Rydym yn defnyddio algorithmau o'r fath, sy'n rhedeg ar gyfrifiaduron Raspberry Pi, i ddatblygu systemau optimeiddio adwaith awtomataidd cost isel mewn cydweithrediad â'r grŵp o Joe Beames. Un o'r rhesymau dros ddatblygu'r systemau hyn yw ein bod yn credu y dylai llwyfannau optimeiddio adwaith fod yn fforddiadwy i bob grŵp ymchwil fel bod ymchwil mewn cemeg yn parhau i fod yn hygyrch i bawb sydd eisiau archwilio syniad synthetig da.
I gael rhagor o wybodaeth am brosiectau penodol sydd ar gael gyda Dr Niek Buurma, edrychwch ar adran Synthesis Moleciwlaidd ein themâu prosiectau ymchwil.
Addysgu
CH5203 Cemeg Organig Systemau Bondio Lluosog
CH5206 Sgiliau allweddol
CH5210 Ymarferol
CH5230 Cemeg Medcinal Ymarferol
CH3315 Strwythur a mecanwaith mewn cemeg organig
CH4405 Technegau Uwch mewn Cemeg Bioffisegol
CHT206 Strwythur a mecanwaith mewn cemeg organig
Collocwiwm CHT216
CHT229 Technegau Uwch mewn Cemeg Bioffisegol
CHT232 Sgiliau allweddol ar gyfer cemegwyr ôl-raddedig
Bywgraffiad
Enillodd Niek ei MSc (1997, cum laude) a PhD (2003, cum laude) o dan oruchwyliaeth yr Athro Dr. Jan B. F. N. Engberts ym Mhrifysgol Groningen, yr Iseldiroedd. Yna roedd Niek yn Gymrawd Ymchwil Ôl-ddoethurol ym Mhrifysgol Sheffield (2002-2006) gyda'r Athro C. A. Hunter a Dr. I. Haq. Penodwyd Niek yn Ddarlithydd mewn Cemeg Organig Ffisegol ym Mhrifysgol Caerdydd yn 2006.
Enillodd Niek Wobr Ymchwil Unilever 1998.
Fel cyfarwyddwr gwirfoddol Rhwydwaith yr Iseldiroedd ar gyfer Academyddion yn y DU (DNA-UK), mae Niek yn aelod o ACB CONNECTS-UK, y platfform pan-UE cyntaf yn y DU gyda'r nod o feithrin cydweithrediadau gwyddonol rhwng yr UE a'r DU.
Aelodaethau proffesiynol
- Cyfarwyddwr Rhwydwaith yr Iseldiroedd ar gyfer Academyddion yn y DU (DNA-UK),
- Aelod o ACB o brosiect CONNECTS-UK a ariennir gan yr UE,
- Aelod o'r Gymdeithas Frenhinol Cemeg,
- Ysgrifennydd Grŵp Cemeg Organig Ffisegol yr RSC,
- Cymrawd yr Academi Addysg Uwch,
- Aelod o dîm craidd Rhwydwaith Cynulliad a Gyfarwyddir gan EPSRC.
Safleoedd academaidd blaenorol
- Gwahoddiad Maître de Conférences yn l'Université de Toulouse 3 - Paul Sabatier 2016
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Ibrahim Alkhaibari Alkhaibari
Oliver McHugh
Hessah Althani
Razan Khalid R Alharbi
Alice Jeffers
Contact Details
+44 29208 70301
Y Prif Adeilad, Ystafell 1.53, Plas y Parc, Caerdydd, CF10 3AT
Themâu ymchwil
Arbenigeddau
- Cemeg organig ffisegol
- cemeg bioffisegol
