![Oliver Castell](https://profiles-cardiff.imgix.net/attachments/2900?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Oliver Castell
Ymchwilydd ar Ddechrau eu Gyrfa ac Uwch Ddarlithydd Ymestyn yr Ymennydd
Ysgol Fferylliaeth a Gwyddorau Fferyllol
Trosolwyg
News
3D-printed microfluidics paper awarded the cover of prestigious journal, Advanced Science - January 2020
3D printing of Lego fluidics - April 2016
Awarded SEB President's Medal, Brighton 2016
Congratulations to Dr Oliver Castell who is to be awarded the President's Medal of the Society for Experimental Biology. Oliver's award is in the cell biology section
Cyhoeddiad
2024
- Silver, K. L. et al. 2024. 3D-printed microfluidic-microwave device for droplet network formation and characterisation. Lab on a Chip 24, pp. 5101-5112. (10.1039/D4LC00387J)
- Dimitriou, P., Li, J., Jamieson, W. D., Schneider, J. J., Castell, O. K. and Barrow, D. A. 2024. Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations. Communications Chemistry 7(1), article number: 120. (10.1038/s42004-024-01209-z)
- Dimitriou, P., Castell, O., Birchall, J. and Li, J. 2024. Label-free volumetric imaging of synthetic cell chassis using optical coherence tomography. Presented at: Cardiff University Engineering Research Conference 2023, Cardiff, UK, 12-14 July 2023 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardif University Engineering Research Conference. Cardiff: Cardiff University Press pp. 15-18., (10.18573/conf1.e)
- Schneider, J. J. et al. 2024. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 161-174., (10.1007/978-3-031-57430-6_13)
- Schneider, J. J. et al. 2024. Kauffman Model with spatially separated ligation and cleavage reactions. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 141-160., (10.1007/978-3-031-57430-6_12)
2023
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
- Matuttis, H. et al. 2023. Computational investigation of the clustering of droplets in widening pipe geometries. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation, Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 82-93., (10.1007/978-3-031-31183-3_7)
- Schneider, J. J. et al. 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation., Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 107-118., (10.1007/978-3-031-31183-3_9)
- Schneider, J. J. et al. 2023. Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets. Communications in Computer and Information Science 1780, pp. 94-106. (10.1007/978-3-031-31183-3_8)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8(6), article number: 2100868. (10.1002/admt.202100868)
2022
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2022. Encapsulated droplet interface bilayers as a platform for high-throughput membrane studies. Soft Matter 18, pp. 5089-5096. (10.1039/D1SM01111A)
- Li, J. et al. 2022. Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation. Nature Communications 13(1), article number: 4125. (10.1038/s41467-022-31898-w)
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
- Dimitriou, P., Li, J., Jamieson, W., Castell, O. and Barrow, D. 2022. Active content release from synthetic cell interior towards a novel drug delivery method. Presented at: MicroTAS 2022, Hangzhou, China, 23-27 October 2022.
2021
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8(1), article number: 2003167. (10.1002/advs.202003167)
2020
- Hardinge, P., Baxani, D. K., McCloy, T., Murray, J. A. H. and Castell, O. K. 2020. Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells. Scientific Reports 10(1), article number: 21886. (10.1038/s41598-020-78996-7)
- Thomas, S. K. et al. 2020. Site-specific protein photochemical covalent attachment to carbon nanotube side walls and its electronic impact on single molecule function. Bioconjugate Chemistry 31(3), pp. 584-594. (10.1021/acs.bioconjchem.9b00719)
- Li, J., Baxani Kamal, D., Jamieson, W. D., Xu, W., Garcia Rocha, V., Barrow, D. A. and Castell, O. K. 2020. Formation of polarised, functional artificial cells from compartmentalised droplet networks and nanomaterials, using one-step, dual-material 3D-printed microfluidics. Advanced Science 7(1), article number: 1901719. (10.1002/advs.201901719)
- Li, J., Dimitriou, P., Castell, O. and Barrow, D. 2020. Generation of complex emulsions using monolithic, dual material 3D-printed microfluidic devices. Presented at: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020), 4-9 October 2020. Cardiff:
2019
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2, article number: 83. (10.1038/s42004-019-0185-5)
2018
- Castell, O. K., Dijkman, P. M., Wiseman, D. N. and Goddard, A. D. 2018. Single molecule fluorescence for membrane proteins. Methods 147, pp. 221-228. (10.1016/j.ymeth.2018.05.024)
- Dijkman, P. M., Castell, O. K., Goddard, A. D., Munoz-Garcia, J. C., de Graaf, C., Wallace, M. I. and Watts, A. 2018. Dynamic tuneable G protein-coupled receptor monomer-dimer populations. Nature Communications 9(1), article number: 1710. (10.1038/s41467-018-03727-6)
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2018. An encapsulated droplet interface bilayer array for the high-throughput optical measurement of lipid membranes with single bilayer resolution. Biophysical Journal 114(3), pp. 686A. (10.1016/j.bpj.2017.11.3699)
2017
- Baxani Kamal, D., Morgan, A. J., Li, J., Barrow, D. A. and Castell, O. 2017. The microfluidic manufacture of encapsulated droplet interface bilayers using a hybrid 3D-printed coaxial device. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, New York: Curran Associates, Inc.
- Li, J., Baxani Kamal, D., Castell, O. and Barrow, D. 2017. Formation of chemically responsive multisomes using droplet microfluidics. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.
2016
- Baxani, D. K., Morgan, A. J. L., Jamieson, W. D., Allender, C. J., Barrow, D. A. and Castell, O. K. 2016. Bilayer networks within a hydrogel shell: A robust chassis for artificial cells and a platform for membrane studies. Angewandte Chemie International Edition 55(46), pp. 14240-14245. (10.1002/anie.201607571)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
2015
- Huang, S., Romero-Ruiz, M., Castell, O. K., Bayley, H. and Wallace, M. I. 2015. High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 10, pp. 986-991. (10.1038/nnano.2015.189)
2013
- Leptihn, S. et al. 2013. Constructing droplet interface bilayers from the contact of aqueous droplets in oil. Nature Protocols 8(6), pp. 1048-1057. (10.1038/nprot.2013.061)
2012
- Castell, O. K., Berridge, J. and Wallace, M. I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51(13), pp. 3134-3138. (10.1002/anie.201107343)
2011
- Castell, O. K., Barrow, D. A., Kamarudin, A. K. and Allender, C. J. 2011. Current practices for describing the performance of molecularly imprinted polymers can be misleading and may be hampering the development of the field. Journal of Molecular Recognition 24(6), pp. 1115-1122. (10.1002/jmr.1161)
- Gross, L. C. M., Castell, O. K. and Wallace, M. I. 2011. Dynamic and reversible control of 2D membrane protein concentration in a droplet interface bilayer. Nano Letters 11(8), pp. 3324-3328. (10.1021/nl201689v)
- Barrow, D. A., Castell, O. K., Sykes, N., Myers, P. and Ritchie, H. 2011. A microfabricated graphitic carbon column for high performance liquid chromatography. Journal of Chromatography A 1218(15), pp. 1983-1987. (10.1016/j.chroma.2010.11.086)
2009
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2009. Liquid-liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows. Lab on a Chip 9(3), pp. 388-396. (10.1039/b806946h)
- Allender, C. J., Castell, O. K., Davies, P. R., Fiddy, S., Hedin-Dahlström, J. A. C. and Stockenhuber, M. 2009. A glimpse of the inner workings of the templated site. Chemical Communications 2009(2), pp. 165-167. (10.1039/b811578h)
2008
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2008. Continuous molecular enrichment in microfluidic systems. Lab on a Chip 8(7), pp. 1031-1033. (10.1039/b800521d)
- Castell, O. K. 2008. Microfluidic devices for continuous liquid-liquid-solid chemical extractions.. PhD Thesis, Cardiff University.
2006
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2006. Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents. Biosensors and bioelectronics 22(4), pp. 526-533. (10.1016/j.bios.2006.07.017)
Cynadleddau
- Dimitriou, P., Castell, O., Birchall, J. and Li, J. 2024. Label-free volumetric imaging of synthetic cell chassis using optical coherence tomography. Presented at: Cardiff University Engineering Research Conference 2023, Cardiff, UK, 12-14 July 2023 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardif University Engineering Research Conference. Cardiff: Cardiff University Press pp. 15-18., (10.18573/conf1.e)
- Schneider, J. J. et al. 2024. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 161-174., (10.1007/978-3-031-57430-6_13)
- Schneider, J. J. et al. 2024. Kauffman Model with spatially separated ligation and cleavage reactions. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 141-160., (10.1007/978-3-031-57430-6_12)
- Matuttis, H. et al. 2023. Computational investigation of the clustering of droplets in widening pipe geometries. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation, Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 82-93., (10.1007/978-3-031-31183-3_7)
- Schneider, J. J. et al. 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation., Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 107-118., (10.1007/978-3-031-31183-3_9)
- Dimitriou, P., Li, J., Jamieson, W., Castell, O. and Barrow, D. 2022. Active content release from synthetic cell interior towards a novel drug delivery method. Presented at: MicroTAS 2022, Hangzhou, China, 23-27 October 2022.
- Li, J., Dimitriou, P., Castell, O. and Barrow, D. 2020. Generation of complex emulsions using monolithic, dual material 3D-printed microfluidic devices. Presented at: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020), 4-9 October 2020. Cardiff:
- Baxani Kamal, D., Morgan, A. J., Li, J., Barrow, D. A. and Castell, O. 2017. The microfluidic manufacture of encapsulated droplet interface bilayers using a hybrid 3D-printed coaxial device. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, New York: Curran Associates, Inc.
- Li, J., Baxani Kamal, D., Castell, O. and Barrow, D. 2017. Formation of chemically responsive multisomes using droplet microfluidics. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.
Erthyglau
- Silver, K. L. et al. 2024. 3D-printed microfluidic-microwave device for droplet network formation and characterisation. Lab on a Chip 24, pp. 5101-5112. (10.1039/D4LC00387J)
- Dimitriou, P., Li, J., Jamieson, W. D., Schneider, J. J., Castell, O. K. and Barrow, D. A. 2024. Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations. Communications Chemistry 7(1), article number: 120. (10.1038/s42004-024-01209-z)
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
- Schneider, J. J. et al. 2023. Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets. Communications in Computer and Information Science 1780, pp. 94-106. (10.1007/978-3-031-31183-3_8)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8(6), article number: 2100868. (10.1002/admt.202100868)
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2022. Encapsulated droplet interface bilayers as a platform for high-throughput membrane studies. Soft Matter 18, pp. 5089-5096. (10.1039/D1SM01111A)
- Li, J. et al. 2022. Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation. Nature Communications 13(1), article number: 4125. (10.1038/s41467-022-31898-w)
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8(1), article number: 2003167. (10.1002/advs.202003167)
- Hardinge, P., Baxani, D. K., McCloy, T., Murray, J. A. H. and Castell, O. K. 2020. Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells. Scientific Reports 10(1), article number: 21886. (10.1038/s41598-020-78996-7)
- Thomas, S. K. et al. 2020. Site-specific protein photochemical covalent attachment to carbon nanotube side walls and its electronic impact on single molecule function. Bioconjugate Chemistry 31(3), pp. 584-594. (10.1021/acs.bioconjchem.9b00719)
- Li, J., Baxani Kamal, D., Jamieson, W. D., Xu, W., Garcia Rocha, V., Barrow, D. A. and Castell, O. K. 2020. Formation of polarised, functional artificial cells from compartmentalised droplet networks and nanomaterials, using one-step, dual-material 3D-printed microfluidics. Advanced Science 7(1), article number: 1901719. (10.1002/advs.201901719)
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2, article number: 83. (10.1038/s42004-019-0185-5)
- Castell, O. K., Dijkman, P. M., Wiseman, D. N. and Goddard, A. D. 2018. Single molecule fluorescence for membrane proteins. Methods 147, pp. 221-228. (10.1016/j.ymeth.2018.05.024)
- Dijkman, P. M., Castell, O. K., Goddard, A. D., Munoz-Garcia, J. C., de Graaf, C., Wallace, M. I. and Watts, A. 2018. Dynamic tuneable G protein-coupled receptor monomer-dimer populations. Nature Communications 9(1), article number: 1710. (10.1038/s41467-018-03727-6)
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2018. An encapsulated droplet interface bilayer array for the high-throughput optical measurement of lipid membranes with single bilayer resolution. Biophysical Journal 114(3), pp. 686A. (10.1016/j.bpj.2017.11.3699)
- Baxani, D. K., Morgan, A. J. L., Jamieson, W. D., Allender, C. J., Barrow, D. A. and Castell, O. K. 2016. Bilayer networks within a hydrogel shell: A robust chassis for artificial cells and a platform for membrane studies. Angewandte Chemie International Edition 55(46), pp. 14240-14245. (10.1002/anie.201607571)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
- Huang, S., Romero-Ruiz, M., Castell, O. K., Bayley, H. and Wallace, M. I. 2015. High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 10, pp. 986-991. (10.1038/nnano.2015.189)
- Leptihn, S. et al. 2013. Constructing droplet interface bilayers from the contact of aqueous droplets in oil. Nature Protocols 8(6), pp. 1048-1057. (10.1038/nprot.2013.061)
- Castell, O. K., Berridge, J. and Wallace, M. I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51(13), pp. 3134-3138. (10.1002/anie.201107343)
- Castell, O. K., Barrow, D. A., Kamarudin, A. K. and Allender, C. J. 2011. Current practices for describing the performance of molecularly imprinted polymers can be misleading and may be hampering the development of the field. Journal of Molecular Recognition 24(6), pp. 1115-1122. (10.1002/jmr.1161)
- Gross, L. C. M., Castell, O. K. and Wallace, M. I. 2011. Dynamic and reversible control of 2D membrane protein concentration in a droplet interface bilayer. Nano Letters 11(8), pp. 3324-3328. (10.1021/nl201689v)
- Barrow, D. A., Castell, O. K., Sykes, N., Myers, P. and Ritchie, H. 2011. A microfabricated graphitic carbon column for high performance liquid chromatography. Journal of Chromatography A 1218(15), pp. 1983-1987. (10.1016/j.chroma.2010.11.086)
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2009. Liquid-liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows. Lab on a Chip 9(3), pp. 388-396. (10.1039/b806946h)
- Allender, C. J., Castell, O. K., Davies, P. R., Fiddy, S., Hedin-Dahlström, J. A. C. and Stockenhuber, M. 2009. A glimpse of the inner workings of the templated site. Chemical Communications 2009(2), pp. 165-167. (10.1039/b811578h)
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2008. Continuous molecular enrichment in microfluidic systems. Lab on a Chip 8(7), pp. 1031-1033. (10.1039/b800521d)
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2006. Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents. Biosensors and bioelectronics 22(4), pp. 526-533. (10.1016/j.bios.2006.07.017)
Gosodiad
- Castell, O. K. 2008. Microfluidic devices for continuous liquid-liquid-solid chemical extractions.. PhD Thesis, Cardiff University.
Gwefannau
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
Ymchwil
Mae Ymchwil yn y labordy ar groesffordd y gwyddorau biolegol a ffisegol, ac mae’n ymwneud â datblygiad a chymhwysiad technegau newydd i helpu i ddatrys cymhlethdod systemau byw.
O foleciwlau sengl mewn systemau model bach iawn i fesuriadau mewn celloedd a meinweoedd cymhleth, gall cymhwyso Cemeg, Ffiseg a Pheirianneg yn greadigol daflu goleuni ar systemau biolegol i ateb cwestiynau pwysig gyda goblygiadau pellgyrhaeddol ar gyfer meddygaeth, bio-dechnoleg a'n dealltwriaeth sylfaenol o'r byd o'n cwmpas. Yn ei dro, mae gennym ddiddordeb mewn cymhwyso'r wybodaeth hon i ddatblygu deunyddiau ac offer newydd a ysbrydolir gan fioleg. Drwy lunio ein gallu i beiriannu ar lefel foleciwlaidd, bydd llawer o gymwysiadau pwysig yn deillio o ddatblygu’r deunyddiau meddal, clyfar, newydd, mewn meysydd fel therapiwteg, bioelectroneg, synhwyro, cyfrifiadura cemegol a chelloedd synthetig.
Trosolwg
Hyd yma, mae fy ymchwil wedi canolbwyntio'n bennaf ar gellbilenni a sut mae cydrannau cellbilen fel lipidau a phroteinau yn gweithredu a'u trefniant digymell mewn ymateb i'w hamgylchedd. Mae microsgopeg TIRF yn dechneg egwyddorol yn y labordy, gan alluogi delweddu moleciwlau sengl. Mae hyn yn ein galluogi i weld y tu hwnt i ymddygiad ensemble a nodweddu deinameg digwyddiadau unigol.
Rydym yn defnyddio microhylifeg a micro-beirianneg i drin a diffinio amodau ar raddfa micro, gan greu offer galluogi ar gyfer microsgopeg a phrosesau trwybwn uchel. Rydym yn gweithio'n agos gyda chydweithwyr academaidd o ystod o ddisgyblaethau yn ein hymchwil ac rydym bob amser yn awyddus i feddwl am ffyrdd cyffrous o ddatrys problemau neu ateb cwestiynau biolegol perthnasol.
Addysgu
- PH1122 Rôl y fferyllydd mewn ymarfer proffesiynol
- PH3202 Methodoleg ymchwil
- PH4116 Prosiect ysgoloriaeth neu ymchwil ym maes fferylliaeth
Bywgraffiad
Cefais fy mhenodi'n Gymrawd Ymchwil SBP i Brifysgol Caerdydd a Darlithydd ym mis Medi 2013. A finnau’n Fferyllydd drwy hyfforddiant, enillais fy PhD (Prifysgol Caerdydd) mewn microhylifeg amlwedd, gan fanteisio ar nodweddion unigryw llif ar ficro-raddfa ar gyfer gwahaniadau cemegol effeithlonrwydd uchel, gwaith a gafodd enwebiad ar gyfer Gwobr Goffa Desty am Arloesedd mewn Gwyddoniaeth Gwahanu.
Yna es ymlaen i weithio ar brosiect a ariennir gan y Bwrdd Strategaeth Dechnoleg sy'n cynnig atebion micro a nano-dechnoleg i'r heriau a wynebir yn y diwydiant gwyddonol, cyn symud i labordy Mark Wallace ym Mhrifysgol Rhydychen ar gyfer ymchwil ôl-ddoethurol i ddatblygu llwyfannau sgrinio trwybwn-uchel ar gyfer mesur swyddogaeth proteinau pilenni’n optegol.
Yn Rhydychen, roeddwn hefyd yn gallu dilyn fy niddordeb mewn gwyddoniaeth a bioffiseg fwy sylfaenol gydag astudiaethau un moleciwl o broteinau pilen mewn dwyhaenau rhyngwyneb defnyn (DIBs) - gwaith cydweithredol yr wyf yn dal i ymgymryd ag ef. Gan weithio rhwng Prifysgol Rhydychen a KTH Stockholm, ymgymerais ag ymchwil wedyn fel rhan o brosiect ymchwil gwerth £5M a ariennir gan EPSRC (Crymedd Anghymesur a Phatrymu Integredig drwy bob Graddfa Hyd). Prosiect graddfa-fawr, traws-sefydliadol, rhyngddisgyblaethol yw hwn, dan arweiniad Coleg Imperial Llundain, sy'n gweithio ym maes peirianneg pilenni moleciwlaidd. Nawr yng Nghaerdydd, rwy'n parhau i gymryd rhan yng nghonsortiwm CAPITALS.
Mae gen i ddiddordeb brwd hefyd mewn ymgysylltu â gwyddoniaeth drwy'r celfyddydau, perfformio cerddoriaeth ryngweithiol ar thema gwyddoniaeth yng Ngardd Einstein yng Ngŵyl y Dyn Gwyrdd 2013 a chael ffotograffau gwyddonol o'm hymchwil i'w gweld yn Arddangosfa Delweddau Ymchwil Amgueddfa Genedlaethol Cymru.
Aelodaethau proffesiynol
Rwy'n aelod cyswllt o brosiect ymchwil a ariennir gan EPSRC, cydweithrediad amlddisgyblaethol ar raddfa fawr rhwng prifysgolion blaenllaw'r DU sy'n gweithio ym maes peirianneg pilenni moleciwlaidd.
Contact Details
CastellO@caerdydd.ac.uk
+44 29208 76241
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
+44 29208 76241
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
