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Dr Oliver Castell
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Oliver Castell
Darllenydd mewn Bioleg Peirianneg
Trosolwyg
Mae Oliver Castell yn Ddarllenydd mewn Bioleg Peirianneg. Mae ei labordy yn canolbwyntio ar ddatblygu technolegau newydd ar gyfer astudio bioleg, a chymhwyso'r wybodaeth hon, i greu deunyddiau craff mater meddal newydd, wedi'u hysbrydoli gan systemau biolegol.
Mae ei labordy yn datblygu technolegau newydd ar gyfer astudio proteinau bilen a defnyddio egwyddorion bioleg peirianneg, cymhwyso'r wybodaeth hon i greu deunyddiau swyddogaethol newydd sy'n effeithio ar wyddorau biofeddygol.
Mae'n Arweinydd Gwyddonol Prosiect Pathfinder EIC Horizon yr UE € 3.3M Bio-HhOST sy'n peirianneg modelau meinwe uwch o gelloedd byw ac artiffisial, ac sy'n arwain Gwobr Bioleg Cenhadaeth BBSRC gwerth £1.6 miliwn ALMOND sy'n datblygu llwyfan technoleg o ddeunyddiau bio-hybrid a chelloedd artiffisial i wella amddiffyn a thwf cnydau.
Cyhoeddiad
2024
- Silver, K. L. et al. 2024. 3D-printed microfluidic-microwave device for droplet network formation and characterisation. Lab on a Chip 24, pp. 5101-5112. (10.1039/D4LC00387J)
- Dimitriou, P., Li, J., Jamieson, W. D., Schneider, J. J., Castell, O. K. and Barrow, D. A. 2024. Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations. Communications Chemistry 7(1), article number: 120. (10.1038/s42004-024-01209-z)
- Dimitriou, P., Castell, O., Birchall, J. and Li, J. 2024. Label-free volumetric imaging of synthetic cell chassis using optical coherence tomography. Presented at: Cardiff University Engineering Research Conference 2023, Cardiff, UK, 12-14 July 2023 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardif University Engineering Research Conference. Cardiff: Cardiff University Press pp. 15-18., (10.18573/conf1.e)
- Schneider, J. J. et al. 2024. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 161-174., (10.1007/978-3-031-57430-6_13)
- Schneider, J. J. et al. 2024. Kauffman Model with spatially separated ligation and cleavage reactions. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 141-160., (10.1007/978-3-031-57430-6_12)
2023
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
- Matuttis, H. et al. 2023. Computational investigation of the clustering of droplets in widening pipe geometries. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation, Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 82-93., (10.1007/978-3-031-31183-3_7)
- Schneider, J. J. et al. 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation., Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 107-118., (10.1007/978-3-031-31183-3_9)
- Schneider, J. J. et al. 2023. Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets. Communications in Computer and Information Science 1780, pp. 94-106. (10.1007/978-3-031-31183-3_8)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8(6), article number: 2100868. (10.1002/admt.202100868)
2022
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2022. Encapsulated droplet interface bilayers as a platform for high-throughput membrane studies. Soft Matter 18, pp. 5089-5096. (10.1039/D1SM01111A)
- Li, J. et al. 2022. Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation. Nature Communications 13(1), article number: 4125. (10.1038/s41467-022-31898-w)
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
- Dimitriou, P., Li, J., Jamieson, W., Castell, O. and Barrow, D. 2022. Active content release from synthetic cell interior towards a novel drug delivery method. Presented at: MicroTAS 2022, Hangzhou, China, 23-27 October 2022.
2021
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8(1), article number: 2003167. (10.1002/advs.202003167)
2020
- Hardinge, P., Baxani, D. K., McCloy, T., Murray, J. A. H. and Castell, O. K. 2020. Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells. Scientific Reports 10(1), article number: 21886. (10.1038/s41598-020-78996-7)
- Thomas, S. K. et al. 2020. Site-specific protein photochemical covalent attachment to carbon nanotube side walls and its electronic impact on single molecule function. Bioconjugate Chemistry 31(3), pp. 584-594. (10.1021/acs.bioconjchem.9b00719)
- Li, J., Baxani Kamal, D., Jamieson, W. D., Xu, W., Garcia Rocha, V., Barrow, D. A. and Castell, O. K. 2020. Formation of polarised, functional artificial cells from compartmentalised droplet networks and nanomaterials, using one-step, dual-material 3D-printed microfluidics. Advanced Science 7(1), article number: 1901719. (10.1002/advs.201901719)
- Li, J., Dimitriou, P., Castell, O. and Barrow, D. 2020. Generation of complex emulsions using monolithic, dual material 3D-printed microfluidic devices. Presented at: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020), 4-9 October 2020. Cardiff:
2019
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2, article number: 83. (10.1038/s42004-019-0185-5)
2018
- Castell, O. K., Dijkman, P. M., Wiseman, D. N. and Goddard, A. D. 2018. Single molecule fluorescence for membrane proteins. Methods 147, pp. 221-228. (10.1016/j.ymeth.2018.05.024)
- Dijkman, P. M., Castell, O. K., Goddard, A. D., Munoz-Garcia, J. C., de Graaf, C., Wallace, M. I. and Watts, A. 2018. Dynamic tuneable G protein-coupled receptor monomer-dimer populations. Nature Communications 9(1), article number: 1710. (10.1038/s41467-018-03727-6)
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2018. An encapsulated droplet interface bilayer array for the high-throughput optical measurement of lipid membranes with single bilayer resolution. Biophysical Journal 114(3), pp. 686A. (10.1016/j.bpj.2017.11.3699)
2017
- Baxani Kamal, D., Morgan, A. J., Li, J., Barrow, D. A. and Castell, O. 2017. The microfluidic manufacture of encapsulated droplet interface bilayers using a hybrid 3D-printed coaxial device. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, New York: Curran Associates, Inc.
- Li, J., Baxani Kamal, D., Castell, O. and Barrow, D. 2017. Formation of chemically responsive multisomes using droplet microfluidics. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.
2016
- Baxani, D. K., Morgan, A. J. L., Jamieson, W. D., Allender, C. J., Barrow, D. A. and Castell, O. K. 2016. Bilayer networks within a hydrogel shell: A robust chassis for artificial cells and a platform for membrane studies. Angewandte Chemie International Edition 55(46), pp. 14240-14245. (10.1002/anie.201607571)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
2015
- Huang, S., Romero-Ruiz, M., Castell, O. K., Bayley, H. and Wallace, M. I. 2015. High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 10, pp. 986-991. (10.1038/nnano.2015.189)
2013
- Leptihn, S. et al. 2013. Constructing droplet interface bilayers from the contact of aqueous droplets in oil. Nature Protocols 8(6), pp. 1048-1057. (10.1038/nprot.2013.061)
2012
- Castell, O. K., Berridge, J. and Wallace, M. I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51(13), pp. 3134-3138. (10.1002/anie.201107343)
2011
- Castell, O. K., Barrow, D. A., Kamarudin, A. K. and Allender, C. J. 2011. Current practices for describing the performance of molecularly imprinted polymers can be misleading and may be hampering the development of the field. Journal of Molecular Recognition 24(6), pp. 1115-1122. (10.1002/jmr.1161)
- Gross, L. C. M., Castell, O. K. and Wallace, M. I. 2011. Dynamic and reversible control of 2D membrane protein concentration in a droplet interface bilayer. Nano Letters 11(8), pp. 3324-3328. (10.1021/nl201689v)
- Barrow, D. A., Castell, O. K., Sykes, N., Myers, P. and Ritchie, H. 2011. A microfabricated graphitic carbon column for high performance liquid chromatography. Journal of Chromatography A 1218(15), pp. 1983-1987. (10.1016/j.chroma.2010.11.086)
2009
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2009. Liquid-liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows. Lab on a Chip 9(3), pp. 388-396. (10.1039/b806946h)
- Allender, C. J., Castell, O. K., Davies, P. R., Fiddy, S., Hedin-Dahlström, J. A. C. and Stockenhuber, M. 2009. A glimpse of the inner workings of the templated site. Chemical Communications 2009(2), pp. 165-167. (10.1039/b811578h)
2008
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2008. Continuous molecular enrichment in microfluidic systems. Lab on a Chip 8(7), pp. 1031-1033. (10.1039/b800521d)
- Castell, O. K. 2008. Microfluidic devices for continuous liquid-liquid-solid chemical extractions.. PhD Thesis, Cardiff University.
2006
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2006. Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents. Biosensors and bioelectronics 22(4), pp. 526-533. (10.1016/j.bios.2006.07.017)
Articles
- Silver, K. L. et al. 2024. 3D-printed microfluidic-microwave device for droplet network formation and characterisation. Lab on a Chip 24, pp. 5101-5112. (10.1039/D4LC00387J)
- Dimitriou, P., Li, J., Jamieson, W. D., Schneider, J. J., Castell, O. K. and Barrow, D. A. 2024. Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations. Communications Chemistry 7(1), article number: 120. (10.1038/s42004-024-01209-z)
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13(1), article number: 20832. (10.1038/s41598-023-47289-0)
- Schneider, J. J. et al. 2023. Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets. Communications in Computer and Information Science 1780, pp. 94-106. (10.1007/978-3-031-31183-3_8)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8(6), article number: 2100868. (10.1002/admt.202100868)
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2022. Encapsulated droplet interface bilayers as a platform for high-throughput membrane studies. Soft Matter 18, pp. 5089-5096. (10.1039/D1SM01111A)
- Li, J. et al. 2022. Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation. Nature Communications 13(1), article number: 4125. (10.1038/s41467-022-31898-w)
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8(1), article number: 2003167. (10.1002/advs.202003167)
- Hardinge, P., Baxani, D. K., McCloy, T., Murray, J. A. H. and Castell, O. K. 2020. Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells. Scientific Reports 10(1), article number: 21886. (10.1038/s41598-020-78996-7)
- Thomas, S. K. et al. 2020. Site-specific protein photochemical covalent attachment to carbon nanotube side walls and its electronic impact on single molecule function. Bioconjugate Chemistry 31(3), pp. 584-594. (10.1021/acs.bioconjchem.9b00719)
- Li, J., Baxani Kamal, D., Jamieson, W. D., Xu, W., Garcia Rocha, V., Barrow, D. A. and Castell, O. K. 2020. Formation of polarised, functional artificial cells from compartmentalised droplet networks and nanomaterials, using one-step, dual-material 3D-printed microfluidics. Advanced Science 7(1), article number: 1901719. (10.1002/advs.201901719)
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2, article number: 83. (10.1038/s42004-019-0185-5)
- Castell, O. K., Dijkman, P. M., Wiseman, D. N. and Goddard, A. D. 2018. Single molecule fluorescence for membrane proteins. Methods 147, pp. 221-228. (10.1016/j.ymeth.2018.05.024)
- Dijkman, P. M., Castell, O. K., Goddard, A. D., Munoz-Garcia, J. C., de Graaf, C., Wallace, M. I. and Watts, A. 2018. Dynamic tuneable G protein-coupled receptor monomer-dimer populations. Nature Communications 9(1), article number: 1710. (10.1038/s41467-018-03727-6)
- Baxani, D. K., Jamieson, W. D., Barrow, D. A. and Castell, O. K. 2018. An encapsulated droplet interface bilayer array for the high-throughput optical measurement of lipid membranes with single bilayer resolution. Biophysical Journal 114(3), pp. 686A. (10.1016/j.bpj.2017.11.3699)
- Baxani, D. K., Morgan, A. J. L., Jamieson, W. D., Allender, C. J., Barrow, D. A. and Castell, O. K. 2016. Bilayer networks within a hydrogel shell: A robust chassis for artificial cells and a platform for membrane studies. Angewandte Chemie International Edition 55(46), pp. 14240-14245. (10.1002/anie.201607571)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
- Huang, S., Romero-Ruiz, M., Castell, O. K., Bayley, H. and Wallace, M. I. 2015. High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 10, pp. 986-991. (10.1038/nnano.2015.189)
- Leptihn, S. et al. 2013. Constructing droplet interface bilayers from the contact of aqueous droplets in oil. Nature Protocols 8(6), pp. 1048-1057. (10.1038/nprot.2013.061)
- Castell, O. K., Berridge, J. and Wallace, M. I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51(13), pp. 3134-3138. (10.1002/anie.201107343)
- Castell, O. K., Barrow, D. A., Kamarudin, A. K. and Allender, C. J. 2011. Current practices for describing the performance of molecularly imprinted polymers can be misleading and may be hampering the development of the field. Journal of Molecular Recognition 24(6), pp. 1115-1122. (10.1002/jmr.1161)
- Gross, L. C. M., Castell, O. K. and Wallace, M. I. 2011. Dynamic and reversible control of 2D membrane protein concentration in a droplet interface bilayer. Nano Letters 11(8), pp. 3324-3328. (10.1021/nl201689v)
- Barrow, D. A., Castell, O. K., Sykes, N., Myers, P. and Ritchie, H. 2011. A microfabricated graphitic carbon column for high performance liquid chromatography. Journal of Chromatography A 1218(15), pp. 1983-1987. (10.1016/j.chroma.2010.11.086)
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2009. Liquid-liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows. Lab on a Chip 9(3), pp. 388-396. (10.1039/b806946h)
- Allender, C. J., Castell, O. K., Davies, P. R., Fiddy, S., Hedin-Dahlström, J. A. C. and Stockenhuber, M. 2009. A glimpse of the inner workings of the templated site. Chemical Communications 2009(2), pp. 165-167. (10.1039/b811578h)
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2008. Continuous molecular enrichment in microfluidic systems. Lab on a Chip 8(7), pp. 1031-1033. (10.1039/b800521d)
- Castell, O. K., Allender, C. J. and Barrow, D. A. 2006. Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents. Biosensors and bioelectronics 22(4), pp. 526-533. (10.1016/j.bios.2006.07.017)
Conferences
- Dimitriou, P., Castell, O., Birchall, J. and Li, J. 2024. Label-free volumetric imaging of synthetic cell chassis using optical coherence tomography. Presented at: Cardiff University Engineering Research Conference 2023, Cardiff, UK, 12-14 July 2023 Presented at Spezi, E. and Bray, M. eds.Proceedings of the Cardif University Engineering Research Conference. Cardiff: Cardiff University Press pp. 15-18., (10.18573/conf1.e)
- Schneider, J. J. et al. 2024. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 161-174., (10.1007/978-3-031-57430-6_13)
- Schneider, J. J. et al. 2024. Kauffman Model with spatially separated ligation and cleavage reactions. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation, Venice, 6-8 September 2023 Presented at Villani, M., Cagnoni, S. and Serra, R. eds.Artificial Life and Evolutionary Computation. WIVACE 2023, Vol. 1977. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 141-160., (10.1007/978-3-031-57430-6_12)
- Matuttis, H. et al. 2023. Computational investigation of the clustering of droplets in widening pipe geometries. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation, Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 82-93., (10.1007/978-3-031-31183-3_7)
- Schneider, J. J. et al. 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation, Gaeta, Italy, 14-16 September 2022 Presented at De Stefano, C., Fontanella, F. and Vanneschi, L. eds.WIVACE 2022. Artificial Life and Evolutionary Computation., Vol. 1780. Communications in Computer and Information Science Cham, Switzerland: Springer pp. 107-118., (10.1007/978-3-031-31183-3_9)
- Dimitriou, P., Li, J., Jamieson, W., Castell, O. and Barrow, D. 2022. Active content release from synthetic cell interior towards a novel drug delivery method. Presented at: MicroTAS 2022, Hangzhou, China, 23-27 October 2022.
- Li, J., Dimitriou, P., Castell, O. and Barrow, D. 2020. Generation of complex emulsions using monolithic, dual material 3D-printed microfluidic devices. Presented at: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020), 4-9 October 2020. Cardiff:
- Baxani Kamal, D., Morgan, A. J., Li, J., Barrow, D. A. and Castell, O. 2017. The microfluidic manufacture of encapsulated droplet interface bilayers using a hybrid 3D-printed coaxial device. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, New York: Curran Associates, Inc.
- Li, J., Baxani Kamal, D., Castell, O. and Barrow, D. 2017. Formation of chemically responsive multisomes using droplet microfluidics. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016), Dublin, Ireland, 9-13 October 2016Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.
Thesis
- Castell, O. K. 2008. Microfluidic devices for continuous liquid-liquid-solid chemical extractions.. PhD Thesis, Cardiff University.
Websites
- Nan, X. et al. 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online]. medRxix: (10.1101/2022.01.06.21268555) Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1
Ymchwil
Mae ymchwil yn y labordy ar groesffordd y gwyddorau biolegol a ffisegol ac mae'n ymwneud â datblygu a chymhwyso technegau newydd i helpu i ddatrys cymhlethdod systemau byw.
O foleciwlau sengl mewn systemau model lleiaf posibl i fesuriadau mewn celloedd a meinweoedd cymhleth, gall cymhwyso Cemeg, Ffiseg, Bioleg a Pheirianneg yn greadigol daflu goleuni ar systemau biolegol i ateb cwestiynau pwysig gyda goblygiadau pellgyrhaeddol ar gyfer meddygaeth, biotechnoleg a'n dealltwriaeth sylfaenol o'r byd o'n cwmpas.
Yn ei dro, mae gennym ddiddordeb mewn cymhwyso'r wybodaeth hon i ddatblygiad deunyddiau ac offer newydd wedi'u hysbrydoli gan fioleg. Trwy lunio ein gallu i beiriannu ar y lefel foleciwlaidd a thrwy harneisio elfennau ac egwyddorion biolegol, bydd gan ddatblygu deunyddiau newydd, craff, meddal a deinamig lawer o gymwysiadau pwysig mewn meysydd fel therapiwteg, bioelectroneg, synhwyro, cyfrifiadura cemegol a chelloedd synthetig.
Mae'r Cell Membrane
O ddiddordeb arbennig yw'r gellbilen a sut mae cydrannau bilen fel lipidau a phroteinau yn gweithredu a'u sefydliad digymell mewn ymateb i'w hamgylchedd. Mae cymhlethdod ffwythiant sy'n codi o'r bilen a'i chydrannau yn ffynhonnell o ddiddordeb ac ysbrydoliaeth.
Offer a Thechnolegau
Mae delweddu Moleciwl Sengl Dynamig yn dechneg egwyddor yn y labordy. Rydym yn adeiladu systemau microsgopeg laser arferol i'n galluogi i weld y tu hwnt i ymddygiad ensemble a nodweddu deinameg digwyddiadau unigol. Gyda'r dulliau hyn rydym wedi datgelu mewnwelediadau newydd i fecanweithiau dadmereiddio GPCR, yn ogystal â delweddu swyddogaeth ion-sianel a nodweddu deunyddiau bio-hybrid newydd ar gyfer cysylltu swyddogaeth protein ag electroneg cyflwr solet.
Rydym yn defnyddio microhylifeg a micro-beirianneg i drin a diffinio amodau ar y raddfa ficro, gan greu offer galluogi ar gyfer microsgopeg, prosesau trwybwn uchel a ffurfio celloedd artiffisial sy'n seiliedig ar bilen.
Celloedd Artiffisial
Wedi'i lywio gan y ddealltwriaeth sylfaenol a gynhyrchir yn y labordy, rydym wedi datblygu celloedd artiffisial sy'n seiliedig ar bilen sy'n addas i'w defnyddio y tu allan i'r labordy. Trwy ailgyfansoddi proteinau bilen swyddogaethol, metaboleddau biocemegol, ac ychwanegu at elfennau synthetig, ein nod yw peiriannu swyddogaeth ddeinamig ac ymatebol i'w defnyddio fel deunyddiau swyddogaethol y genhedlaeth nesaf. Yn dechnoleg sy'n dod i'r amlwg gyda'r potensial i drawsnewid llawer o sectorau a helpu i fynd i'r afael â heriau byd-eang, rydym wrthi'n datblygu'r deunyddiau hyn i'w cymhwyso mewn peirianneg meinwe, meddygaeth a diogelwch bwyd, yn ogystal â'u defnydd mewn ymchwil sylfaenol.
Projectau
Mae'r prif brosiectau yn y labordy yn cynnwys:
Prosiect Pathfinder Horizon EIC cyfredol € 3.3M yr UE Bio-HhOST sy'n beirianneg modelau meinwe uwch o gelloedd byw ac artiffisial lle mae Oliver Castell yn gwasanaethu fel Arweinydd Gwyddonol.
Oliver Castell sy'n arwain Gwobr Cenhadaeth Bioleg Peirianneg UKRI / BBSRC gwerth £1.6M ALMOND SY'N DATBLYGU LLWYFAN TECHNOLEG O DDEUNYDDIAU BIO-HYBRID A CHELLOEDD ARTIFFISIAL I WELLA AMDDIFFYN A THWF CNYDAU.
Daeth i ben yn ddiweddar Prosiect Technolegau Newydd yr UE Horizon 2020 yr UE yn y dyfodol ACDC – Celloedd Artiffisial gyda Cores Ddosbarthedig i Swyddogaeth Protein Decipher - a oedd yn canolbwyntio ar ddatblygu pensaernïaeth celloedd artiffisial swyddogaethol. Gwasanaethodd Oliver Castell fel Arweinydd Pecyn Gwaith ac yn ddiweddarach, Arweinydd Gwyddonol.
Cydweithio
Rydym yn gweithio'n agos gyda chydweithwyr academaidd o ystod o ddisgyblaethau yn ein hymchwil ac rydym bob amser yn awyddus i feddwl am ffyrdd cyffrous o ddatrys problemau, ateb cwestiynau biolegol perthnasol a datblygu offer a thechnolegau newydd. Cysylltwch â ni os oes gennych ddiddordeb mewn gweithio gyda ni.
Cefnogi Cymrodoriaethau, Ysgoloriaethau ac Ymchwilwyr Ymweld
Rydym bob amser yn awyddus i gefnogi a chynnal ymchwilwyr talentog sydd â diddordeb mewn ymuno â'r labordy. Cysylltwch â ni os ydych yn chwilio am westeiwr cefnogol ar gyfer cymrodoriaeth ôl-ddoethurol, ysgoloriaeth PhD neu gyfleoedd ôl-raddedig hunan-ariannu, neu i ymweld fel ymchwilydd ymweliad.
Gweler yma am restr gynhwysfawr (ond di-gynhwysfawr) o gyfleoedd cymrodoriaeth.
Addysgu
Rwy'n arwain modiwl Prosiectau Ymchwil y Flwyddyn Olaf ac yn addysgu ar draws pedair blynedd rhaglen MPharm achrededig broffesiynol Caerdydd.
Contact Details
CastellO@caerdydd.ac.uk
+44 29208 76241
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
+44 29208 76241
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
Themâu ymchwil
Arbenigeddau
- Gwyddoniaeth Moleciwl Sengl
- Celloedd Artiffisial
- Proteinau bilen a bioleg bilen
- Bioleg synthetig
- Mater meddal a microhylifeg droplet
