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Dr Oliver Castell
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Oliver Castell
Darllenydd mewn Bioleg Peirianneg
Trosolwyg
Mae Oliver Castell yn Ddarllenydd mewn Bioleg Peirianneg. Mae ei labordy yn canolbwyntio ar ddatblygu technolegau newydd ar gyfer astudio bioleg, a chymhwyso'r wybodaeth hon, i greu deunyddiau craff mater meddal newydd, wedi'u hysbrydoli gan systemau biolegol.
Mae ei labordy yn datblygu technolegau newydd ar gyfer astudio proteinau bilen a defnyddio egwyddorion bioleg peirianneg, cymhwyso'r wybodaeth hon i greu deunyddiau swyddogaethol newydd sy'n effeithio ar wyddorau biofeddygol.
Mae'n Arweinydd Gwyddonol Prosiect Pathfinder EIC Horizon yr UE € 3.3M Bio-HhOST sy'n peirianneg modelau meinwe uwch o gelloedd byw ac artiffisial, ac sy'n arwain Gwobr Bioleg Cenhadaeth BBSRC gwerth £1.6 miliwn ALMOND sy'n datblygu llwyfan technoleg o ddeunyddiau bio-hybrid a chelloedd artiffisial i wella amddiffyn a thwf cnydau.
Cyhoeddiad
2026
- Xu, D. et al. 2026. Biomimetic hierarchical scaffold with Zn2+/Mg2+ dual-ion synergistic release for sequential immunomodulation to enhance bone regeneration. Chemical Engineering Journal 545 179660. (10.1016/j.cej.2026.179660)
- Wirawan, R. et al., 2026. Structural basis for independent pore function of Vpb4 from Bacillus thuringiensis. Nature Communications 17 8198. (10.1038/s41467-026-74567-y)
2025
- Tsubaki, S. et al., 2025. Radiofrequency and microwave 3D bioprinting of emulsion gel for dysphagia diets. Scientific Reports 15 (1) 25023. (10.1038/s41598-025-06804-1)
- Ahmed, R. D. et al. 2025. Molecular dynamics guided identification of a brighter variant of superfolder Green Fluorescent Protein with increased photobleaching resistance. Communications Chemistry 8 174. (10.1038/s42004-025-01573-4)
2024
- Silver, K. L. et al. 2024. 3D-printed microfluidic-microwave device for droplet network formation and characterisation. Lab on a Chip 24 , pp.5101-5112. (10.1039/D4LC00387J)
- Dimitriou, P. et al. 2024. Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations. Communications Chemistry 7 (1) 120. (10.1038/s42004-024-01209-z)
- Dimitriou, P. et al. 2024. Label-free volumetric imaging of synthetic cell chassis using optical coherence tomography. Presented at: Cardiff University Engineering Research Conference 2023 Cardiff, UK 12-14 July 2023. Published in: Spezi, E. and Bray, M. eds. Proceedings of the Cardif University Engineering Research Conference. Cardiff: Cardiff University Press. , pp.15-18. (10.18573/conf1.e)
- Schneider, J. J. et al., 2024. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation Venice 6-8 September 2023. Published in: Villani, M. , Cagnoni, S. and Serra, R. eds. Artificial Life and Evolutionary Computation. WIVACE 2023. Vol. 1977.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.161-174. (10.1007/978-3-031-57430-6_13)
- Schneider, J. J. et al., 2024. Kauffman Model with spatially separated ligation and cleavage reactions. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation Venice 6-8 September 2023. Published in: Villani, M. , Cagnoni, S. and Serra, R. eds. Artificial Life and Evolutionary Computation. WIVACE 2023. Vol. 1977.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.141-160. (10.1007/978-3-031-57430-6_12)
2023
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13 (1) 20832. (10.1038/s41598-023-47289-0)
- Matuttis, H. et al., 2023. Computational investigation of the clustering of droplets in widening pipe geometries. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation Gaeta, Italy 14-16 September 2022. Published in: De Stefano, C. , Fontanella, F. and Vanneschi, L. eds. WIVACE 2022. Artificial Life and Evolutionary Computation. Vol. 1780.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.82-93. (10.1007/978-3-031-31183-3_7)
- Schneider, J. J. et al., 2023. Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets. Communications in Computer and Information Science 1780 , pp.94-106. (10.1007/978-3-031-31183-3_8)
- Schneider, J. J. et al., 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation Gaeta, Italy 14-16 September 2022. Published in: De Stefano, C. , Fontanella, F. and Vanneschi, L. eds. WIVACE 2022. Artificial Life and Evolutionary Computation.. Vol. 1780.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.107-118. (10.1007/978-3-031-31183-3_9)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8 (6) 2100868. (10.1002/admt.202100868)
2022
- Baxani, D. K. et al. 2022. Encapsulated droplet interface bilayers as a platform for high-throughput membrane studies. Soft Matter 18 , pp.5089-5096. (10.1039/D1SM01111A)
- Li, J. et al. 2022. Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation. Nature Communications 13 (1) 4125. (10.1038/s41467-022-31898-w)
- Nan, X. et al., 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online].medRxix: (10.1101/2022.01.06.21268555)Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1.
- Dimitriou, P. et al. 2022. Active content release from synthetic cell interior towards a novel drug delivery method. Presented at: MicroTAS 2022 Hangzhou, China 23-27 October 2022.
2021
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8 (1) 2003167. (10.1002/advs.202003167)
2020
- Hardinge, P. et al. 2020. Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells. Scientific Reports 10 (1) 21886. (10.1038/s41598-020-78996-7)
- Thomas, S. K. et al. 2020. Site-specific protein photochemical covalent attachment to carbon nanotube side walls and its electronic impact on single molecule function. Bioconjugate Chemistry 31 (3), pp.584-594. (10.1021/acs.bioconjchem.9b00719)
- Li, J. et al. 2020. Formation of polarised, functional artificial cells from compartmentalised droplet networks and nanomaterials, using one-step, dual-material 3D-printed microfluidics. Advanced Science 7 (1) 1901719. (10.1002/advs.201901719)
- Li, J. et al. 2020. Generation of complex emulsions using monolithic, dual material 3D-printed microfluidic devices. Presented at: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020) 4-9 October 2020. Cardiff:
2019
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2 83. (10.1038/s42004-019-0185-5)
2018
- Castell, O. K. et al. 2018. Single molecule fluorescence for membrane proteins. Methods 147 , pp.221-228. (10.1016/j.ymeth.2018.05.024)
- Dijkman, P. M. et al., 2018. Dynamic tuneable G protein-coupled receptor monomer-dimer populations. Nature Communications 9 (1) 1710. (10.1038/s41467-018-03727-6)
- Baxani, D. K. et al., 2018. An encapsulated droplet interface bilayer array for the high-throughput optical measurement of lipid membranes with single bilayer resolution. Biophysical Journal 114 (3), pp.686A. (10.1016/j.bpj.2017.11.3699)
2017
- Baxani Kamal, D. et al. 2017. The microfluidic manufacture of encapsulated droplet interface bilayers using a hybrid 3D-printed coaxial device. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) Dublin, Ireland 9-13 October 2016. Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, New York: Curran Associates, Inc.
- Li, J. et al. 2017. Formation of chemically responsive multisomes using droplet microfluidics. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) Dublin, Ireland 9-13 October 2016. Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.
2016
- Baxani, D. K. et al., 2016. Bilayer networks within a hydrogel shell: A robust chassis for artificial cells and a platform for membrane studies. Angewandte Chemie International Edition 55 (46), pp.14240-14245. (10.1002/anie.201607571)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11 (4) e0152023. (10.1371/journal.pone.0152023)
2015
- Huang, S. et al., 2015. High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 10 , pp.986-991. (10.1038/nnano.2015.189)
2013
- Leptihn, S. et al., 2013. Constructing droplet interface bilayers from the contact of aqueous droplets in oil. Nature Protocols 8 (6), pp.1048-1057. (10.1038/nprot.2013.061)
2012
- Castell, O. K. , Berridge, J. and Wallace, M. I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51 (13), pp.3134-3138. (10.1002/anie.201107343)
2011
- Barrow, D. A. et al. 2011. A microfabricated graphitic carbon column for high performance liquid chromatography. Journal of Chromatography A 1218 (15), pp.1983-1987. (10.1016/j.chroma.2010.11.086)
- Castell, O. K. et al. 2011. Current practices for describing the performance of molecularly imprinted polymers can be misleading and may be hampering the development of the field. Journal of Molecular Recognition 24 (6), pp.1115-1122. (10.1002/jmr.1161)
- Gross, L. C. M. , Castell, O. K. and Wallace, M. I. 2011. Dynamic and reversible control of 2D membrane protein concentration in a droplet interface bilayer. Nano Letters 11 (8), pp.3324-3328. (10.1021/nl201689v)
2009
- Castell, O. K. , Allender, C. J. and Barrow, D. A. 2009. Liquid-liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows. Lab on a Chip 9 (3), pp.388-396. (10.1039/b806946h)
- Allender, C. J. et al. 2009. A glimpse of the inner workings of the templated site. Chemical Communications 2009 (2), pp.165-167. (10.1039/b811578h)
2008
- Castell, O. K. 2008. Microfluidic devices for continuous liquid-liquid-solid chemical extractions.. PhD Thesis , Cardiff University.
- Castell, O. K. , Allender, C. J. and Barrow, D. A. 2008. Continuous molecular enrichment in microfluidic systems. Lab on a Chip 8 (7), pp.1031-1033. (10.1039/b800521d)
2006
- Castell, O. K. , Allender, C. J. and Barrow, D. A. 2006. Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents. Biosensors and bioelectronics 22 (4), pp.526-533. (10.1016/j.bios.2006.07.017)
Cynadleddau
- Dimitriou, P. et al. 2024. Label-free volumetric imaging of synthetic cell chassis using optical coherence tomography. Presented at: Cardiff University Engineering Research Conference 2023 Cardiff, UK 12-14 July 2023. Published in: Spezi, E. and Bray, M. eds. Proceedings of the Cardif University Engineering Research Conference. Cardiff: Cardiff University Press. , pp.15-18. (10.18573/conf1.e)
- Schneider, J. J. et al., 2024. Percolation breakdown in binary and ternary monodisperse and polydisperse systems of spherical particles. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation Venice 6-8 September 2023. Published in: Villani, M. , Cagnoni, S. and Serra, R. eds. Artificial Life and Evolutionary Computation. WIVACE 2023. Vol. 1977.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.161-174. (10.1007/978-3-031-57430-6_13)
- Schneider, J. J. et al., 2024. Kauffman Model with spatially separated ligation and cleavage reactions. Presented at: Italian Workshop on Artificial Life and Evolutionary Computation Venice 6-8 September 2023. Published in: Villani, M. , Cagnoni, S. and Serra, R. eds. Artificial Life and Evolutionary Computation. WIVACE 2023. Vol. 1977.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.141-160. (10.1007/978-3-031-57430-6_12)
- Matuttis, H. et al., 2023. Computational investigation of the clustering of droplets in widening pipe geometries. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation Gaeta, Italy 14-16 September 2022. Published in: De Stefano, C. , Fontanella, F. and Vanneschi, L. eds. WIVACE 2022. Artificial Life and Evolutionary Computation. Vol. 1780.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.82-93. (10.1007/978-3-031-31183-3_7)
- Schneider, J. J. et al., 2023. Artificial chemistry performed in an agglomeration of droplets with restricted molecule transfer. Presented at: WIVACE 2022, XVI International Workshop on Artificial Life and Evolutionary Computation Gaeta, Italy 14-16 September 2022. Published in: De Stefano, C. , Fontanella, F. and Vanneschi, L. eds. WIVACE 2022. Artificial Life and Evolutionary Computation.. Vol. 1780.Communications in Computer and Information Science Cham, Switzerland: Springer. , pp.107-118. (10.1007/978-3-031-31183-3_9)
- Dimitriou, P. et al. 2022. Active content release from synthetic cell interior towards a novel drug delivery method. Presented at: MicroTAS 2022 Hangzhou, China 23-27 October 2022.
- Li, J. et al. 2020. Generation of complex emulsions using monolithic, dual material 3D-printed microfluidic devices. Presented at: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2020) 4-9 October 2020. Cardiff:
- Baxani Kamal, D. et al. 2017. The microfluidic manufacture of encapsulated droplet interface bilayers using a hybrid 3D-printed coaxial device. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) Dublin, Ireland 9-13 October 2016. Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, New York: Curran Associates, Inc.
- Li, J. et al. 2017. Formation of chemically responsive multisomes using droplet microfluidics. Presented at: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) Dublin, Ireland 9-13 October 2016. Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.
Erthyglau
- Xu, D. et al. 2026. Biomimetic hierarchical scaffold with Zn2+/Mg2+ dual-ion synergistic release for sequential immunomodulation to enhance bone regeneration. Chemical Engineering Journal 545 179660. (10.1016/j.cej.2026.179660)
- Wirawan, R. et al., 2026. Structural basis for independent pore function of Vpb4 from Bacillus thuringiensis. Nature Communications 17 8198. (10.1038/s41467-026-74567-y)
- Tsubaki, S. et al., 2025. Radiofrequency and microwave 3D bioprinting of emulsion gel for dysphagia diets. Scientific Reports 15 (1) 25023. (10.1038/s41598-025-06804-1)
- Ahmed, R. D. et al. 2025. Molecular dynamics guided identification of a brighter variant of superfolder Green Fluorescent Protein with increased photobleaching resistance. Communications Chemistry 8 174. (10.1038/s42004-025-01573-4)
- Silver, K. L. et al. 2024. 3D-printed microfluidic-microwave device for droplet network formation and characterisation. Lab on a Chip 24 , pp.5101-5112. (10.1039/D4LC00387J)
- Dimitriou, P. et al. 2024. Manipulation of encapsulated artificial phospholipid membranes using sub-micellar lysolipid concentrations. Communications Chemistry 7 (1) 120. (10.1038/s42004-024-01209-z)
- Nan, X. et al. 2023. VarLOCK: sequencing-independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. Scientific Reports 13 (1) 20832. (10.1038/s41598-023-47289-0)
- Schneider, J. J. et al., 2023. Network creation during agglomeration processes of polydisperse and monodisperse systems of droplets. Communications in Computer and Information Science 1780 , pp.94-106. (10.1007/978-3-031-31183-3_8)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8 (6) 2100868. (10.1002/admt.202100868)
- Baxani, D. K. et al. 2022. Encapsulated droplet interface bilayers as a platform for high-throughput membrane studies. Soft Matter 18 , pp.5089-5096. (10.1039/D1SM01111A)
- Li, J. et al. 2022. Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation. Nature Communications 13 (1) 4125. (10.1038/s41467-022-31898-w)
- Pope, J. R. et al. 2021. Association of fluorescent protein pairs and it's significant impact on fluorescence and energy transfer. Advanced Science 8 (1) 2003167. (10.1002/advs.202003167)
- Hardinge, P. et al. 2020. Bioluminescent detection of isothermal DNA amplification in microfluidic generated droplets and artificial cells. Scientific Reports 10 (1) 21886. (10.1038/s41598-020-78996-7)
- Thomas, S. K. et al. 2020. Site-specific protein photochemical covalent attachment to carbon nanotube side walls and its electronic impact on single molecule function. Bioconjugate Chemistry 31 (3), pp.584-594. (10.1021/acs.bioconjchem.9b00719)
- Li, J. et al. 2020. Formation of polarised, functional artificial cells from compartmentalised droplet networks and nanomaterials, using one-step, dual-material 3D-printed microfluidics. Advanced Science 7 (1) 1901719. (10.1002/advs.201901719)
- Worthy, H. L. et al. 2019. Positive functional synergy of structurally integrated artificial protein dimers assembled by Click chemistry. Communications Chemistry 2 83. (10.1038/s42004-019-0185-5)
- Castell, O. K. et al. 2018. Single molecule fluorescence for membrane proteins. Methods 147 , pp.221-228. (10.1016/j.ymeth.2018.05.024)
- Dijkman, P. M. et al., 2018. Dynamic tuneable G protein-coupled receptor monomer-dimer populations. Nature Communications 9 (1) 1710. (10.1038/s41467-018-03727-6)
- Baxani, D. K. et al., 2018. An encapsulated droplet interface bilayer array for the high-throughput optical measurement of lipid membranes with single bilayer resolution. Biophysical Journal 114 (3), pp.686A. (10.1016/j.bpj.2017.11.3699)
- Baxani, D. K. et al., 2016. Bilayer networks within a hydrogel shell: A robust chassis for artificial cells and a platform for membrane studies. Angewandte Chemie International Edition 55 (46), pp.14240-14245. (10.1002/anie.201607571)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11 (4) e0152023. (10.1371/journal.pone.0152023)
- Huang, S. et al., 2015. High-throughput optical sensing of nucleic acids in a nanopore array. Nature Nanotechnology 10 , pp.986-991. (10.1038/nnano.2015.189)
- Leptihn, S. et al., 2013. Constructing droplet interface bilayers from the contact of aqueous droplets in oil. Nature Protocols 8 (6), pp.1048-1057. (10.1038/nprot.2013.061)
- Castell, O. K. , Berridge, J. and Wallace, M. I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51 (13), pp.3134-3138. (10.1002/anie.201107343)
- Barrow, D. A. et al. 2011. A microfabricated graphitic carbon column for high performance liquid chromatography. Journal of Chromatography A 1218 (15), pp.1983-1987. (10.1016/j.chroma.2010.11.086)
- Castell, O. K. et al. 2011. Current practices for describing the performance of molecularly imprinted polymers can be misleading and may be hampering the development of the field. Journal of Molecular Recognition 24 (6), pp.1115-1122. (10.1002/jmr.1161)
- Gross, L. C. M. , Castell, O. K. and Wallace, M. I. 2011. Dynamic and reversible control of 2D membrane protein concentration in a droplet interface bilayer. Nano Letters 11 (8), pp.3324-3328. (10.1021/nl201689v)
- Castell, O. K. , Allender, C. J. and Barrow, D. A. 2009. Liquid-liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows. Lab on a Chip 9 (3), pp.388-396. (10.1039/b806946h)
- Allender, C. J. et al. 2009. A glimpse of the inner workings of the templated site. Chemical Communications 2009 (2), pp.165-167. (10.1039/b811578h)
- Castell, O. K. , Allender, C. J. and Barrow, D. A. 2008. Continuous molecular enrichment in microfluidic systems. Lab on a Chip 8 (7), pp.1031-1033. (10.1039/b800521d)
- Castell, O. K. , Allender, C. J. and Barrow, D. A. 2006. Novel biphasic separations utilising highly selective molecularly imprinted polymers as biorecognition solvent extraction agents. Biosensors and bioelectronics 22 (4), pp.526-533. (10.1016/j.bios.2006.07.017)
Gosodiad
- Castell, O. K. 2008. Microfluidic devices for continuous liquid-liquid-solid chemical extractions.. PhD Thesis , Cardiff University.
Gwefannau
- Nan, X. et al., 2022. VarLOCK - sequencing independent, rapid detection of SARS-CoV-2 variants of concern for point-of-care testing, qPCR pipelines and national wastewater surveillance. [Online].medRxix: (10.1101/2022.01.06.21268555)Available at: https://www.medrxiv.org/content/10.1101/2022.01.06.21268555v1.
Ymchwil
Mae ymchwil yn y labordy ar groesffordd y gwyddorau biolegol a ffisegol ac mae'n ymwneud â datblygu a chymhwyso technegau newydd i helpu i ddatrys cymhlethdod systemau byw.
O foleciwlau sengl mewn systemau model lleiaf posibl i fesuriadau mewn celloedd a meinweoedd cymhleth, gall cymhwyso Cemeg, Ffiseg, Bioleg a Pheirianneg yn greadigol daflu goleuni ar systemau biolegol i ateb cwestiynau pwysig gyda goblygiadau pellgyrhaeddol ar gyfer meddygaeth, biotechnoleg a'n dealltwriaeth sylfaenol o'r byd o'n cwmpas.
Yn ei dro, mae gennym ddiddordeb mewn cymhwyso'r wybodaeth hon i ddatblygiad deunyddiau ac offer newydd wedi'u hysbrydoli gan fioleg. Trwy lunio ein gallu i beiriannu ar y lefel foleciwlaidd a thrwy harneisio elfennau ac egwyddorion biolegol, bydd gan ddatblygu deunyddiau newydd, craff, meddal a deinamig lawer o gymwysiadau pwysig mewn meysydd fel therapiwteg, bioelectroneg, synhwyro, cyfrifiadura cemegol a chelloedd synthetig.
Mae'r Cell Membrane
O ddiddordeb arbennig yw'r gellbilen a sut mae cydrannau bilen fel lipidau a phroteinau yn gweithredu a'u sefydliad digymell mewn ymateb i'w hamgylchedd. Mae cymhlethdod ffwythiant sy'n codi o'r bilen a'i chydrannau yn ffynhonnell o ddiddordeb ac ysbrydoliaeth.
Offer a Thechnolegau
Mae delweddu Moleciwl Sengl Dynamig yn dechneg egwyddor yn y labordy. Rydym yn adeiladu systemau microsgopeg laser arferol i'n galluogi i weld y tu hwnt i ymddygiad ensemble a nodweddu deinameg digwyddiadau unigol. Gyda'r dulliau hyn rydym wedi datgelu mewnwelediadau newydd i fecanweithiau dadmereiddio GPCR, yn ogystal â delweddu swyddogaeth ion-sianel a nodweddu deunyddiau bio-hybrid newydd ar gyfer cysylltu swyddogaeth protein ag electroneg cyflwr solet.
Rydym yn defnyddio microhylifeg a micro-beirianneg i drin a diffinio amodau ar y raddfa ficro, gan greu offer galluogi ar gyfer microsgopeg, prosesau trwybwn uchel a ffurfio celloedd artiffisial sy'n seiliedig ar bilen.
Celloedd Artiffisial
Wedi'i lywio gan y ddealltwriaeth sylfaenol a gynhyrchir yn y labordy, rydym wedi datblygu celloedd artiffisial sy'n seiliedig ar bilen sy'n addas i'w defnyddio y tu allan i'r labordy. Trwy ailgyfansoddi proteinau bilen swyddogaethol, metaboleddau biocemegol, ac ychwanegu at elfennau synthetig, ein nod yw peiriannu swyddogaeth ddeinamig ac ymatebol i'w defnyddio fel deunyddiau swyddogaethol y genhedlaeth nesaf. Yn dechnoleg sy'n dod i'r amlwg gyda'r potensial i drawsnewid llawer o sectorau a helpu i fynd i'r afael â heriau byd-eang, rydym wrthi'n datblygu'r deunyddiau hyn i'w cymhwyso mewn peirianneg meinwe, meddygaeth a diogelwch bwyd, yn ogystal â'u defnydd mewn ymchwil sylfaenol.
Projectau
Mae'r prif brosiectau yn y labordy yn cynnwys:
Prosiect Pathfinder Horizon EIC cyfredol € 3.3M yr UE Bio-HhOST sy'n beirianneg modelau meinwe uwch o gelloedd byw ac artiffisial lle mae Oliver Castell yn gwasanaethu fel Arweinydd Gwyddonol.
Oliver Castell sy'n arwain Gwobr Cenhadaeth Bioleg Peirianneg UKRI / BBSRC gwerth £1.6M ALMOND SY'N DATBLYGU LLWYFAN TECHNOLEG O DDEUNYDDIAU BIO-HYBRID A CHELLOEDD ARTIFFISIAL I WELLA AMDDIFFYN A THWF CNYDAU.
Daeth i ben yn ddiweddar Prosiect Technolegau Newydd yr UE Horizon 2020 yr UE yn y dyfodol ACDC – Celloedd Artiffisial gyda Cores Ddosbarthedig i Swyddogaeth Protein Decipher - a oedd yn canolbwyntio ar ddatblygu pensaernïaeth celloedd artiffisial swyddogaethol. Gwasanaethodd Oliver Castell fel Arweinydd Pecyn Gwaith ac yn ddiweddarach, Arweinydd Gwyddonol.
Cydweithio
Rydym yn gweithio'n agos gyda chydweithwyr academaidd o ystod o ddisgyblaethau yn ein hymchwil ac rydym bob amser yn awyddus i feddwl am ffyrdd cyffrous o ddatrys problemau, ateb cwestiynau biolegol perthnasol a datblygu offer a thechnolegau newydd. Cysylltwch â ni os oes gennych ddiddordeb mewn gweithio gyda ni.
Cefnogi Cymrodoriaethau, Ysgoloriaethau ac Ymchwilwyr Ymweld
Rydym bob amser yn awyddus i gefnogi a chynnal ymchwilwyr talentog sydd â diddordeb mewn ymuno â'r labordy. Cysylltwch â ni os ydych yn chwilio am westeiwr cefnogol ar gyfer cymrodoriaeth ôl-ddoethurol, ysgoloriaeth PhD neu gyfleoedd ôl-raddedig hunan-ariannu, neu i ymweld fel ymchwilydd ymweliad.
Gweler yma am restr gynhwysfawr (ond di-gynhwysfawr) o gyfleoedd cymrodoriaeth.
Addysgu
Rwy'n arwain modiwl Prosiectau Ymchwil y Flwyddyn Olaf ac yn addysgu ar draws pedair blynedd rhaglen MPharm achrededig broffesiynol Caerdydd.
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Contact Details
[email protected]
+44 29208 76241
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
+44 29208 76241
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
Themâu ymchwil
Arbenigeddau
- Gwyddoniaeth Moleciwl Sengl
- Celloedd Artiffisial
- Proteinau bilen a bioleg bilen
- Bioleg synthetig
- Mater meddal a microhylifeg droplet
