![Aled Clayton](https://profiles-cardiff.imgix.net/attachments/7567?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Aled Clayton
- Siarad Cymraeg
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Aled Clayton
Cyfarwyddwr Ymchwil
Trosolwyg
I am part of the Tissue Microenvironment Group, School of Medicine, Cardiff University which is a collection of diverse and international researchers with a multidisciplinary approach to science.
My own specialist insterst involves studies of cell-derived vesicles. This is now a rapidly growing and exciting area of biology, but we have been able to establish some expertiese in this field since the early 2000's. The group has published well over 90 papers, most in relation to vesicles, and their roles in subverting immune responses, in controlling the cancer microenvironment and as potential disease biomarkers.
I am interested in understanding the mechanisms by which vesicle biogenesis and secretion is controlled, and the impact such vesicles have on the development and progression of cancer; particularly focussing on prostate cancer. Developing tools and assays to quantify nano-vesicles in biological fluid specimens is also an important aspect of the group's activities.
Although my main focus is in cancer biology, I collaborate broadly with researchers in Cardiff including those in the schools of dentistry, engineering and optometry, and interact with other Universities, on aspects including cardiovascular disease, neurodegenerative diseases and other conditions that impact our society in significant ways.
Cyhoeddiad
2026
- Sanwlani, R. et al., 2026. Pharmacological inhibition of small extracellular vesicle secretion by ALK5i SD‐208 via lysosomal rerouting of CD63+ compartments. Journal of Extracellular Vesicles 15 (9) e70362. (10.1002/jev2.70362)
- Paolini, L. et al., 2026. Biomolecular corona of extracellular vesicles: Report on Isev workshop. Journal of Extracellular Biology 5 (8) e70172. (10.1002/jex2.70172)
- Davies-Jones, J. A. et al., 2026. Unravelling nanoscale chemistries in complex biological systems using photoinduced force microscopy (PiFM). Faraday Discussions 265 , pp.56-75. (10.1039/d5fd00141b)
- Sanwlani, R. et al., 2026. 314 Dietary milk-derived extracellular vesicles are bioavailable to the heart and modulate cardiac cell responses [Abstract]. Heart 112 (S1) A286. (10.1136/heartjnl-2026-bcs.317)
- Veiga, S. et al., 2026. Heparan sulphate glycosaminoglycan chains contribute to the tethering of coronal factors and are important for extracellular vesicle‐mediated fibroblast activation. Journal of Extracellular Biology 5 (5) e70146. (10.1002/jex2.70146)
- Durmaz, E. et al., 2026. Extracellular vesicle–mediated delivery of miR-181a-3p confers neuroprotection to degenerating retinal ganglion cells. Experimental Eye Research 265 110882. (10.1016/j.exer.2026.110882)
2025
- Kapustin, A. N. et al., 2025. Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI. eLife 12 RP90375. (10.7554/elife.90375.3)
- Elfar, M. Y. et al. 2025. Antibiotic carry over is a confounding factor for cell-based antimicrobial research applications. Scientific Reports 15 (1) 28310. (10.1038/s41598-025-14186-7)
- Durmaz, E. et al. 2025. R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma. Neural Regeneration Research 10 4103. (10.4103/NRR.NRR-D-24-00709)
2024
- Zhang, X. et al. 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11 (39) 2403574. (10.1002/advs.202403574)
- Bordanaba-Florit, G. et al., 2024. Integration of proteomic and metabolomic analysis reveal distinct metabolic alterations of prostate cancer-associated fibroblasts compared to normal fibroblasts from patient's stroma samples. BBA - Molecular Basis of Disease 1870 (6) 167229. (10.1016/j.bbadis.2024.167229)
2023
- Hyland, M. et al., 2023. Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports 19 , pp.2391-2406. (10.1007/s12015-023-10586-2)
- Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19 (35) 2300390. (10.1002/smll.202300390)
- Dumcius, P. et al. 2023. Dual-wave acoustofluidic centrifuge for ultrafast concentration of nanoparticles and extracellular vesicles (small 35/2023) [Inside front cover]. Small 19 (35) 2370274. (10.1002/smll.202370274)
- Wang, H. et al. 2023. An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells. Analytica Chimica Acta 1255 341120. (10.1016/j.aca.2023.341120)
2022
- Owen, J. S. , Clayton, A. and Pearson, H. B. 2022. Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer. Biomolecules 13 (1) 67. (10.3390/biom13010067)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11 (8), pp.861-875. (10.1093/stcltm/szac037)
- van Niel, G. et al., 2022. Challenges and directions in studying cell-cell communication by extracellular vesicles. Nature Reviews Molecular Cell Biology 23 , pp.369–382. (10.1038/s41580-022-00460-3)
- Brown, S. V. et al. 2022. Identifying the efficacy of extracellular vesicles in osteogenic differentiation: an EV-Lution in regenerative medicine. Frontiers in Dental Medicine 3 849724. (10.3389/fdmed.2022.849724)
2021
- Brown, H. , Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29 (6), pp.864-880. (10.1111/wrr.12949)
- Mikhaylov, R. et al. 2021. A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres. Journal of Micromechanics and Microengineering 31 (7) 074003. (10.1088/1361-6439/ac0515)
- Erdbrügger, U. et al., 2021. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles 10 (7) e12093. (10.1002/jev2.12093)
- Lanning, B. et al. 2021. Prostate cancer cell extracellular vesicles increase mineralisation of bone osteoblast precursor cells in an in vitro model. Biology 10 (4) 318. (10.3390/biology10040318)
- Wu, F. et al. 2021. An enhanced tilted-angle acoustofluidic chip for cancer cell manipulation. IEEE Electron Device Letters 42 (4), pp.577-580. (10.1109/LED.2021.3062292)
- Evans, L. et al. 2021. Macrophage plasticity and function in the lung tumour microenvironment revealed in 3D heterotypic spheroid and explant models. Biomedicines 9 (3) 302. (10.3390/biomedicines9030302)
2020
- Sun, C. et al., 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67 (8), pp.3355-3361. (10.1109/TED.2020.3002498)
- Mikhaylov, R. et al. 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20 (10), pp.1807-1814. (10.1039/C9LC01192G)
- Bliss, C. M. et al. 2020. Targeting antigen to the surface of EVs improves the in vivo immunogenicity of human and non-human adenoviral vaccines in mice. Molecular Therapy - Methods and Clinical Development 16 , pp.108-125. (10.1016/j.omtm.2019.12.003)
2019
- Clayton, A. et al. 2019. Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles. Journal of Extracellular Vesicles 8 (1) 1647027. (10.1080/20013078.2019.1647027)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9 10136. (10.1038/s41598-019-46585-y)
- Spaull, R. et al., 2019. Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus. International Journal of Developmental Neuroscience 73 , pp.59-65. (10.1016/j.ijdevneu.2019.01.004)
- Seed, R. I. et al., 2019. The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. Scientific Reports 9 (1) 5120. (10.1038/s41598-019-41379-8)
- Faruqu, F. N. et al., 2019. Membrane radiolabelling of exosomes for comparative biodistribution analysis in immunocompetent and immunodeficient mice – a novel and universal approach. Theranostics 9 (6), pp.1666-1682. (10.7150/thno.27891)
2018
- Théry, C. et al., 2018. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles 7 (1) 1535750. (10.1080/20013078.2018.1535750)
- Clayton, A. et al. 2018. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles 7 (1) 1473707. (10.1080/20013078.2018.1473707)
- Yeung, V. et al. 2018. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma. Nanoscale 10 (18), pp.8547-8559. (10.1039/C8NR02417K)
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3 (6) e98459. (10.1172/jci.insight.98459)
- Carter, D. R. F. et al., 2018. Extracellular vesicles in the tumour microenvironment. Philosophical Transactions B: Biological Sciences 373 (1737) 20160475. (10.1098/rstb.2016.0475)
2017
- Martinez, V. G. et al., 2017. Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles. OncoImmunology 6 (12) e1362530. (10.1080/2162402X.2017.1362530)
- Griffiths, S. et al., 2017. Differential proteome analysis of extracellular vesicles from breast cancer cell lines by chaperone affinity enrichment. Proteomes 5 (4) 25. (10.3390/proteomes5040025)
- Roberts-Dalton, H. D. et al. 2017. Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic. Nanoscale 9 (36), pp.13693-13706. (10.1039/C7NR04128D)
- Welton, J. L. et al., 2017. Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis. Journal of Extracellular Vesicles 6 (1) 1369805. (10.1080/20013078.2017.1369805)
- Pathan, M. et al., 2017. A novel community driven software for functional enrichment analysis of extracellular vesicles data. Journal of Extracellular Vesicles 6 1321455. (10.1080/20013078.2017.1321455)
- Salimu, J. et al., 2017. Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes. Journal of Extracellular Vesicles 6 (1) 1368823. (10.1080/20013078.2017.1368823)
2016
- Al-Taei, S. et al. 2016. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: self-amplifying immunosuppression in cancer. OncoImmunology 6 (2), pp.312-318. e1268308. (10.1080/2162402X.2016.1268308)
- Welton, J. L. et al., 2016. Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array. Journal of Extracellular Vesicles 5 31209. (10.3402/jev.v5.31209)
- Emanueli, C. et al., 2016. Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome trafficking out of the human heart with potential for cardiac biomarker discovery. PLoS ONE 11 (4) e0154274. (10.1371/journal.pone.0154274)
- Webber, J. P. et al. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7 , pp.20124-20139. (10.18632/oncotarget.7716)
- Clayton, A. et al. 2016. The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts. Journal of Extracellular Vesicles 5 (1) 30924. (10.3402/jev.v5.30924)
2015
- Connolly, K. D. et al., 2015. Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. Journal of Extracellular Vesicles 4 (s1) 29159. (10.3402/jev.v4.29159)
- Beltrami, C. et al., 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1 (2), pp.151-166. (10.3390/ncrna1020151)
- Salimu, J. et al. 2015. Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells—A Key Role for Heat-Shock Protein 70 and Receptor CD91. Cancer Immunology Research 3 (6), pp.678-688. (10.1158/2326-6066.CIR-14-0079)
- Webber, J. P. , Yeung, V. and Clayton, A. 2015. Extracellular vesicles as modulators of the cancer microenvironment. Seminars in Cell and Developmental Biology 40 , pp.27-34. (10.1016/j.semcdb.2015.01.013)
- Welton, J. L. et al. 2015. Ready-made chromatography columns for extracellular vesicle isolation from plasma. Journal of Extracellular Vesicles 4 27269. (10.3402/jev.v4.27269)
- Chowdhury, R. et al. 2015. Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts. Oncotarget 6 (2), pp.715-731. (10.18632/oncotarget.2711)
- Webber, J. P. et al. 2015. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 (3), pp.290-302. (10.1038/onc.2013.560)
- Kim, D. et al., 2015. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics 31 (6), pp.933-939. (10.1093/bioinformatics/btu741)
2014
- Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29 (12), pp.2756-2763. (10.1093/humrep/deu281)
- Galluzzi, L. et al., 2014. Classification of current anticancer immunotherapies. Oncotargets and Therapy 5 (24), pp.12472-12508. (10.18632/oncotarget.2998)
- Spary, L. K. et al. 2014. Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+PD-L1+phenotype in prostate cancer. OncoImmunology 3 (9) e955331. (10.4161/21624011.2014.955331)
- Spary, L. K. et al. 2014. Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation. The Journal of Immunology 192 (7), pp.3101-3110. (10.4049/jimmunol.1302736)
- Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13 (4), pp.1050-1064. (10.1074/mcp.M113.032136)
2013
- Brennan, S. E. et al., 2013. Prostate cancer exosomes offering novel circulating biomarkers for early cancer diagnosis and prognosis [Abstract]. The Journal of Gene Medicine 15 (8-9), pp.331-332. (10.1002/jgm.2740)
- Midgley, A. C. et al. 2013. Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation Is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. Journal of Biological Chemistry 288 (21), pp.14824-14838. (10.1074/jbc.M113.451336)
- Webber, J. P. and Clayton, A. 2013. How pure are your vesicles?. Journal of Extracellular Vesicles 2 19861. (10.3402/jev.v2i0.19861)
2012
- Kalra, H. et al., 2012. Vesiclepedia: A compendium for extracellular vesicles with continuous community annotation. PLoS Biology 10 (12) e1001450. (10.1371/journal.pbio.1001450)
- Beltrami, C. et al. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4), pp.875-879. (10.1042/BST20120090)
- Clayton, A. 2012. Cancer cells use exosomes as tools to manipulate immunity and the microenvironment. OncoImmunology 1 (1), pp.78-80. (10.4161/onci.1.1.17826)
- Shah, K. M. et al., 2012. Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells [Letter]. Journal of Molecular Cell Biology 5 (1), pp.67-70. (10.1093/jmcb/mjs058)
2011
- Clayton, A. et al. 2011. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. The Journal of Immunology 187 (2), pp.676-683. (10.4049/jimmunol.1003884)
2010
- Webber, J. P. et al. 2010. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Research 70 (23), pp.9621-9630. (10.1158/0008-5472.CAN-10-1722)
- Tabi, Z. et al. 2010. Resistance of CD45RA- T cells to apoptosis and functional impairment, and activation of tumor-antigen specific T cells during radiation therapy of prostate cancer. The Journal of Immunology 185 (2), pp.1330-1339. (10.4049/jimmunol.1000488)
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9 (6), pp.1324-1338. (10.1074/mcp.M000063-MCP201)
2009
- Mitchell, P. J. et al. 2009. Can urinary exosomes act as treatment response markers in prostate cancer?. Journal Of Translational Medicine 7 (4), pp.n/a. (10.1186/1479-5876-7-4)
- Clayton, A. and Mason, M. D. 2009. Exosomes in tumour immunity. Current Oncology -Toronto- 16 (3), pp.46-49.
- Navabi, H. et al., 2009. A clinical grade poly I:C-analogue (Ampligen®) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro. Vaccine 27 (1), pp.107-115. (10.1016/j.vaccine.2008.10.024)
2008
- Clayton, A. et al. 2008. Human tumor-derived exosomes down-modulate NKG2D expression. Journal of Immunology 180 (11), pp.7249-7258.
- Mitchell, J. P. et al. 2008. Increased exosome production from tumour cell cultures using the Integra CELLine Culture System. Journal of Immunological Methods 335 (1-2), pp.98-105. (10.1016/j.jim.2008.03.001)
2007
- Clayton, A. et al. 2007. Human tumour-derived exosomes selectively impair lymphocyte responses to Interleukin-2. Cancer Research 67 , pp.7458-7466. (10.1158/0008-5472.CAN-06-3456)
2006
- Théry, C. et al., 2006. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Current Protocols in Cell Biology Unit 322. (10.1002/0471143030.cb0322s30)
2005
- Clayton, A. et al. 2005. Induction of heat shock proteins in B-cell exosomes. Journal of Cell Science 118 (16), pp.3631-3638. (10.1242/jcs.02494)
- Coleman, S. L. et al. 2005. Recovery of CD8+ T-cell function during systemic chemotherapy in advanced ovarian cancer. Cancer Research 65 (15), pp.7000-7006. (10.1158/0008-5472.CAN-04-3792)
- Adams, M. et al., 2005. The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 23 (17-18), pp.2374-2378. (10.1016/j.vaccine.2005.01.014)
- Navabi, H. et al., 2005. Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial. Blood Cells, Molecules, and Diseases 35 (2), pp.149-152. (10.1016/j.bcmd.2005.06.008)
- Clayton, A. and Tabi, Z. 2005. Exosomes and the MICA-NKG2D system in cancer. Blood Cells, Molecules, and Diseases 34 (3), pp.206-213. (10.1016/j.bcmd.2005.03.003)
2004
- Clayton, A. et al. 2004. Adhesion and signaling by B cell-derived exosomes: the role of integrins. The FASEB Journal 18 , pp.977-979. (10.1096/fj.03-1094fje)
2003
- Thomas, G. J. et al. 2003. Structural and functional changes in heparan sulfate proteoglycan expression associated with the myofibroblastic phenotype. America Journal of Pathology 162 (3), pp.977-989.
- Clayton, A. et al. 2003. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. European Journal of Immunology 33 (2), pp.522-31. (10.1002/immu.200310028)
- Blaber, R. et al., 2003. Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts. Journal of the American Society of Nephrology 14 (1), pp.116-127. (10.1097/01.ASN.0000040595.35207.62)
2002
- Savage, P. et al., 2002. Anti-viral cytotoxic T cells inhibit the growth of cancer cells with antibody targeted hla class I/peptide complexes in scid mice. International Journal of Cancer 98 (4), pp.561-566. (10.1002/ijc.10219)
- Savage, P. et al., 2002. Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes. British Journal of Cancer 86 (8), pp.1336-1342. (10.1038/sj.bjc.6600223)
2001
- Clayton, A. et al. 2001. Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. Journal of Immunological Methods 247 (1-2), pp.163-174. (10.1016/S0022-1759(00)00321-5)
- Clayton, A. et al. 2001. Cell surface heparan sulfate proteoglycans control the response of renal interstitial fibroblasts to fibroblast growth factor-2. Kidney International 59 (6), pp.2084-2094. (10.1046/j.1523-1755.2001.00723.x)
1999
- Clayton, A. and Steadman, R. 1999. ICAM-1 interactions in the renal interstitium: a novel activator of fibroblasts during nephritis. Histology and Histopathology 14 (3), pp.861-870.
- Clayton, A. et al. 1999. Fibroblasts from the cortical interstitium express cell surface heparan sulphate proteoglycans [Abstract]. Kidney International 55 (6), pp.2588-2588. (10.1046/j.1523-1755.2002.t01-1-00456.x)
- Evans, R. E. et al., 1999. Neutrophil binding stimulates the synthesis, release and activation of MMP 3 and MMP 2 from endothelial cells in vitro [Abstract]. Kidney International 55 (5), pp.2105-2105. (10.1046/j.1523-1755.1999.00404.x)
1998
- Clayton, A. et al. 1998. Cellular activation through the ligation of intercellular adhesion molecule-1. Journal of Cell Science 111 (4), pp.443-453.
1997
- Clayton, A. , Steadman, R. and Williams, J. D. 1997. Cells isolated from the human cortical interstitium resemble myofibroblasts and bind neutrophils in an ICAM-1--dependent manner. Journal of the American Society of Nephrology 8 (4), pp.604-615.
- Clayton, A. , Williams, J. D. and Steadman, R. 1997. Ligation of ICAM-1 on the surface of renal cortical fibroblasts stimulates de novo expression of ICAM-1 and VCAM-1 [Abstract]. Kidney International 52 (1), pp.262-263. (10.1038/ki.1997.329)
- Clayton, A. , Williams, J. D. and Steadman, R. 1997. The ligation of ICAM-1 on renal cortical fibroblasts initiates the de novo expression of ICAM-1 and VCAM-1. Journal of the American Society of Nephrology 8 , pp.A2385-A2385.
- Evans, R. A. et al., 1997. Neutrophil binding stimulates the synthesis, release and activation of MMP 2 from endothelial cells in vitro. Journal of the American Society of Nephrology 8 , pp.A2390-A2390.
1996
- Steadman, R. et al. 1996. Leukocytes trigger an influx of calcium in renal interstitial fibroblasts through ligation ICAM-1. Journal of the American Society of Nephrology 7 (9), pp.A2594-A2594.
1995
- Clayton, A. , Steadman, R. and Williams, J. D. 1995. Human renal cortical fibroblasts (RCF) bind leukocytes in-vitro through a CD18-dependent and VLA(4)-dependent interaction. Journal of the American Society of Nephrology 6 (3), pp.894-894.
Erthyglau
- Sanwlani, R. et al., 2026. Pharmacological inhibition of small extracellular vesicle secretion by ALK5i SD‐208 via lysosomal rerouting of CD63+ compartments. Journal of Extracellular Vesicles 15 (9) e70362. (10.1002/jev2.70362)
- Paolini, L. et al., 2026. Biomolecular corona of extracellular vesicles: Report on Isev workshop. Journal of Extracellular Biology 5 (8) e70172. (10.1002/jex2.70172)
- Davies-Jones, J. A. et al., 2026. Unravelling nanoscale chemistries in complex biological systems using photoinduced force microscopy (PiFM). Faraday Discussions 265 , pp.56-75. (10.1039/d5fd00141b)
- Sanwlani, R. et al., 2026. 314 Dietary milk-derived extracellular vesicles are bioavailable to the heart and modulate cardiac cell responses [Abstract]. Heart 112 (S1) A286. (10.1136/heartjnl-2026-bcs.317)
- Veiga, S. et al., 2026. Heparan sulphate glycosaminoglycan chains contribute to the tethering of coronal factors and are important for extracellular vesicle‐mediated fibroblast activation. Journal of Extracellular Biology 5 (5) e70146. (10.1002/jex2.70146)
- Durmaz, E. et al., 2026. Extracellular vesicle–mediated delivery of miR-181a-3p confers neuroprotection to degenerating retinal ganglion cells. Experimental Eye Research 265 110882. (10.1016/j.exer.2026.110882)
- Kapustin, A. N. et al., 2025. Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI. eLife 12 RP90375. (10.7554/elife.90375.3)
- Elfar, M. Y. et al. 2025. Antibiotic carry over is a confounding factor for cell-based antimicrobial research applications. Scientific Reports 15 (1) 28310. (10.1038/s41598-025-14186-7)
- Durmaz, E. et al. 2025. R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma. Neural Regeneration Research 10 4103. (10.4103/NRR.NRR-D-24-00709)
- Zhang, X. et al. 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11 (39) 2403574. (10.1002/advs.202403574)
- Bordanaba-Florit, G. et al., 2024. Integration of proteomic and metabolomic analysis reveal distinct metabolic alterations of prostate cancer-associated fibroblasts compared to normal fibroblasts from patient's stroma samples. BBA - Molecular Basis of Disease 1870 (6) 167229. (10.1016/j.bbadis.2024.167229)
- Hyland, M. et al., 2023. Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports 19 , pp.2391-2406. (10.1007/s12015-023-10586-2)
- Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19 (35) 2300390. (10.1002/smll.202300390)
- Dumcius, P. et al. 2023. Dual-wave acoustofluidic centrifuge for ultrafast concentration of nanoparticles and extracellular vesicles (small 35/2023) [Inside front cover]. Small 19 (35) 2370274. (10.1002/smll.202370274)
- Wang, H. et al. 2023. An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells. Analytica Chimica Acta 1255 341120. (10.1016/j.aca.2023.341120)
- Owen, J. S. , Clayton, A. and Pearson, H. B. 2022. Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer. Biomolecules 13 (1) 67. (10.3390/biom13010067)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11 (8), pp.861-875. (10.1093/stcltm/szac037)
- van Niel, G. et al., 2022. Challenges and directions in studying cell-cell communication by extracellular vesicles. Nature Reviews Molecular Cell Biology 23 , pp.369–382. (10.1038/s41580-022-00460-3)
- Brown, S. V. et al. 2022. Identifying the efficacy of extracellular vesicles in osteogenic differentiation: an EV-Lution in regenerative medicine. Frontiers in Dental Medicine 3 849724. (10.3389/fdmed.2022.849724)
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- Beltrami, C. et al. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4), pp.875-879. (10.1042/BST20120090)
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- Shah, K. M. et al., 2012. Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells [Letter]. Journal of Molecular Cell Biology 5 (1), pp.67-70. (10.1093/jmcb/mjs058)
- Clayton, A. et al. 2011. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. The Journal of Immunology 187 (2), pp.676-683. (10.4049/jimmunol.1003884)
- Webber, J. P. et al. 2010. Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Research 70 (23), pp.9621-9630. (10.1158/0008-5472.CAN-10-1722)
- Tabi, Z. et al. 2010. Resistance of CD45RA- T cells to apoptosis and functional impairment, and activation of tumor-antigen specific T cells during radiation therapy of prostate cancer. The Journal of Immunology 185 (2), pp.1330-1339. (10.4049/jimmunol.1000488)
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9 (6), pp.1324-1338. (10.1074/mcp.M000063-MCP201)
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- Clayton, A. and Mason, M. D. 2009. Exosomes in tumour immunity. Current Oncology -Toronto- 16 (3), pp.46-49.
- Navabi, H. et al., 2009. A clinical grade poly I:C-analogue (Ampligen®) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro. Vaccine 27 (1), pp.107-115. (10.1016/j.vaccine.2008.10.024)
- Clayton, A. et al. 2008. Human tumor-derived exosomes down-modulate NKG2D expression. Journal of Immunology 180 (11), pp.7249-7258.
- Mitchell, J. P. et al. 2008. Increased exosome production from tumour cell cultures using the Integra CELLine Culture System. Journal of Immunological Methods 335 (1-2), pp.98-105. (10.1016/j.jim.2008.03.001)
- Clayton, A. et al. 2007. Human tumour-derived exosomes selectively impair lymphocyte responses to Interleukin-2. Cancer Research 67 , pp.7458-7466. (10.1158/0008-5472.CAN-06-3456)
- Théry, C. et al., 2006. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Current Protocols in Cell Biology Unit 322. (10.1002/0471143030.cb0322s30)
- Clayton, A. et al. 2005. Induction of heat shock proteins in B-cell exosomes. Journal of Cell Science 118 (16), pp.3631-3638. (10.1242/jcs.02494)
- Coleman, S. L. et al. 2005. Recovery of CD8+ T-cell function during systemic chemotherapy in advanced ovarian cancer. Cancer Research 65 (15), pp.7000-7006. (10.1158/0008-5472.CAN-04-3792)
- Adams, M. et al., 2005. The rationale for combined chemo/immunotherapy using a Toll-like receptor 3 (TLR3) agonist and tumour-derived exosomes in advanced ovarian cancer. Vaccine 23 (17-18), pp.2374-2378. (10.1016/j.vaccine.2005.01.014)
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- Clayton, A. et al. 2004. Adhesion and signaling by B cell-derived exosomes: the role of integrins. The FASEB Journal 18 , pp.977-979. (10.1096/fj.03-1094fje)
- Thomas, G. J. et al. 2003. Structural and functional changes in heparan sulfate proteoglycan expression associated with the myofibroblastic phenotype. America Journal of Pathology 162 (3), pp.977-989.
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- Blaber, R. et al., 2003. Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts. Journal of the American Society of Nephrology 14 (1), pp.116-127. (10.1097/01.ASN.0000040595.35207.62)
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- Steadman, R. et al. 1996. Leukocytes trigger an influx of calcium in renal interstitial fibroblasts through ligation ICAM-1. Journal of the American Society of Nephrology 7 (9), pp.A2594-A2594.
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Ymchwil
We are interested in understanding how cells produce small fat-bubbles (vesicles), and why they seem to do this so extensively. Our studies focus on the role of such bubbles in changing the immediate surroundings of the cancer tissue. it seems these bubbles (exosomes) can interfere with the correct function of immune cells, they can encourage formation of blood vessels, and can hijack other neighbouring cells to behave abnormally- all of these effects assist the growth and ultimate spread of the tumour.
We can also detect exosomes in the urine and blood of cancer patients, and we are working hard on developing new methods to isolate exosomes from biological fluids, and to use these as means of discovering new indicators of disease. We have examined the complex array of protein molecules on the vesicles, and are beginning to also look at RNA-molecules, which hide inside the bubble.
Together, these studies will provide much needed information about how the cancer cells can dominate and take-over their microenvironments. Learning how to block these effects is likely to be very useful therapeutically. Pperhaps we can also use the presence of exosomes in urine/blood as future tests to support diagnoses and monitoring of cancer.
Funding sources
- Cancer Research Wales, Programme grant:
- Movember: The Movember Revolutionary Team Award
- Prostate Cancer UK: British Heart Foundation:
- British Lung Foundation:
- CU & ReNeuron:
- Tenovus Cancer Care:
- Welsh Assembly Government NRN Sêr Cymru Award:
Addysgu
Fel llawer o academyddion sy'n canolbwyntio ar ymchwil, rwyf hefyd yn anghytuno â gweithgareddau addysgu israddedig ac ôl-raddedig Coleg y Gwyddorau Bywyd Biolegol , a'r Ysgol Meddygaeth.
Mae'r rhain yn cynnwys, ymhlith eraill:-
Graddau BSc a Ffarmacoleg rhyng-gyfrifedig, Ysgol Meddygaeth:
- Cyfraniadau tuag at ddatblygu, cynnal a marcio prosiectau ymchwil yn y labordy.
- Asesiad o gyflwyniadau ymchwil myfyrwyr a thraethodau hir.
Bioleg Moleciwlaidd Canser, Ysgol Meddygaeth:
- Cyfarfod llawn, EV mewn bioleg canser, cyflwyniad sy'n cwmpasu pynciau gan gynnwys natur ac amrywiaeth EV, hanes darganfod EV, swyddogaethau EV mewn modiwleiddio imiwnedd, angiogenesis, actifadu stroma, lledaenu metastatig.
MBBCh, SSC Bl-1
- Tutotials ac asesydd ar gyfer Prosiectau Adolygu llenyddiaeth dethol, a thiwtorialau/arddangosiadau achlysurol yn seiliedig ar ddulliau labordy ac ati.
Bywgraffiad
Briff Gyrfa.
Rhan o uwch arweinyddiaeth yr Ysgol Feddygaeth, sy'n cwmpasu portffolio eang mewn Ymchwil, Arloesi a Menter. Hefyd, cyd-arweinydd y Grŵp Microamgylchedd Meinwe, gyda diddordebau ymchwil o fewn Canser y Prostad, a bioleg fecanyddol rheoleiddio meinwe.
Anrhydeddau a dyfarniadau
- Visiting Professor for the Finish Government inFlames Programme at the university of Turku https://inflames.utu.fi
Aelodaethau proffesiynol
- Aelod Sylfaenol o'r Gymdeithas Ryngwladol ar gyfer fesiglau Allgellog (ISEV)
- Aelod Sefydlu ac ymddiriedolwr Cymdeithas Llysiau Allgellog y Deyrnas Unedig https://www.ukev.org.uk
Safleoedd academaidd blaenorol
Trosolwg gyrfa
- Athro (Awst 2017- presennol), Is-adran Canser a Geneteg, Prifysgol Caerdydd
- Darlithydd Snr (08/2013-07/2017), Yr Is-adran Canser a Geneteg, Prifysgol Caerdydd
- Darlithydd; (08/2004 i 07/2013), Ysgol Feddygaeth, Prifysgol Caerdydd
- Cymrawd Ymchwil (01/1999 i 07/2004) Ysgol Feddygaeth, Prifysgol Caerdydd
- Cymrawd Ymchwil, (10/1996 i 12/1998) Ysgol Feddygaeth, Prifysgol Caerdydd
Addysg a chymwysterau
- 1997: PhD (Meddygaeth), Sefydliad Neffroleg, Coleg Meddygaeth Prifysgol Cymru.
- 1998: Diploma mewn dulliau Biofeddygol, Coleg Meddygaeth Prifysgol Cymru.
- 1993: BSc (Anrh) Biocemeg, Coleg Prifysgol Cymru, Caerdydd
Pwyllgorau ac adolygu
Pwyllgorau Mewnol
- Aelod o Uwch Dîm Arweinyddiaeth yr Ysgol Feddygaeth (SLT)
- Cadeirydd, Pwyllgor Darganfod i Arloesi (D2I), Ysgol Meddygaeth
- Aelod a Chyd-gadeirydd, Pwyllgor Arloesi i Effaith (I2I), Ysgol Feddygaeth
- Pwyllgor Ymchwil y Brifysgol
- Pwyllgor Cronfa Ymchwil WHRI
Pwyllgorau Allanol
- 2025&26: Prostate Cancer UK, Gwobrau Arloesedd, Panelydd grant
- 2024-25: Pwyllgor Trefnu Rhyngwladol (IOC): Gweithdy ISEV ar Corona Biomoleciwlaidd, Brescia, yr Eidal
- 2024-25: Gwobrau Arloesi Prostate Cancer UK, panel grant.
- 2017: Pwyllgor Gwyddoniaeth a Phwyllgor Aelodaeth, Cymdeithas EV y Deyrnas Unedig
- 2017: Pwyllgor Trefnu. Cyfarfod Trafod y Gymdeithas Frenhinol; EV's in the Tumour Microenvironment (adroddiadau cyhoeddedig)
- 2015-2017: Grŵp Astudiaethau Clinigol NCRI - Grŵp Cynghori Biofarcwyr Moleciwlaidd
- 2015- Fforwm fesigl allgellog y Deyrnas Unedig, trefnydd a chyd-drefnydd cynhadledd flynyddol 2014, 2016 yn parhau.
- 2016- Cymdeithas Ryngwladol ar gyfer Fesiglau Allgellog, Cynhadledd Flynyddol Pwyllgor Trefnu Lleol, Rotterdam
- 2016-2017- Pwyllgor Trefnu, Cyfarfod Trafod y Gymdeithas Frenhinol, EV in the Cancer Microenvironment, Llundain 2017.
Arholwr PhD
- 2024-25. PhD gan wrthwynebydd cyhoeddiad. Prifysgol Aalborg, Denmarc
- 2023. Gwrthwynebydd PhD, Prifysgol Helsinki.
- 2023. Arholwr Mewnol, PhD, Div. Canser a Geneteg, Caerdydd
- 2022. PhD Oponent, Prifysgol Aarhus, Denmarc
- 2021. Arholiad PhD Prifysgol Rhydychen.
- 2021. Arholwr Mewnol, PhD Cardif ar gyfer BIOSCI
- 2019. PhD Oponent, Prifysgol Gothenburg.
- 2018. Cadeirydd Arholiad, PhD Caerdydd
- 2017. Arholwr Allanol, PhD St Andrews.
- 2017. Arholwr Mewnol, PhD, Caerdydd.
- 2016. Cadeirydd Arholiadau, MD Caerdydd
- 2016. Arholwr Allanol, PhD Prifysgol Caerlŷr
- 2015. Ail wrthwynebydd, PhD Oslo, Norwy
- 2014. Arholwr Allanol, PhD Oxford Brookes
- 2013. Arholwr Mewnol, PhD, Caerdydd
Golygydd
- 2012-2017: Aelod Cyswllt o'r Bwrdd Golygyddol - Journal of Extracellular vesicles
- 2013-2016: Bwrdd Golygyddol, Journal of Circulating Biomarkers.
Meysydd goruchwyliaeth
Mae gan y tîm ddiddordeb mawr mewn perswadio astudiaethau sy'n gysylltiedig â
- Mesuriadau / dadansoddeg nano-vesicle
- Cyfathrebu rhynggellog wedi'i gyfryngu gan fesigl gan gynnwys ceisiadau cyflenwi cyffuriau
- vesicles mewn bioleg canser sylfaenol a all gynnwys swyddogaethau imiwnolegol, a rolau wrth fodiwleiddio ffibroblastau sy'n gysylltiedig â chanser
- defnyddioldeb fesiglau fel marcwyr canser (yn enwedig mewn canser y prostad)
- Coron biomoleciwlaidd fesiglau
- Nanoronynnau avesicular a'u natur a'u swyddogaethau mewn canser
Goruchwyliaeth gyfredol
Luana Cardoso
Prosiectau'r gorffennol
- Joanne Welton - Uwch Awdur Meddygol yn HEOR
- Ridwana Chowdhury - Evox Therapeutics
- Vincent Yeung - Sefydliad Ymchwil Llygaid Schepens | Ysgol Feddygol Harvard.
- Alex Cocks - GSK
- Sara Viega - Ysbyty Cyffredinol Massachusetts | Ysgol Feddygol Harvard.
- Mariama Mbengue - Ysgrifennwr Meddygol
News articles
Contact Details
[email protected]
+44 29225 10589
Adeilad Tenovus, Ystafell GF16, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Neuadd Meirionnydd, Ystafell Llawr 1af, Deoniaeth, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
+44 29225 10589
Adeilad Tenovus, Ystafell GF16, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Neuadd Meirionnydd, Ystafell Llawr 1af, Deoniaeth, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
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Arbenigeddau
- Bioleg Celloedd
- Bioleg celloedd canser
- Canser y prostad
- Llysiau allgellog
- Biofarcwyr
