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Dr Sion Coulman
Darllenydd mewn Fferylliaeth a Gwyddorau Fferyllol
Ysgol Fferylliaeth a Gwyddorau Fferyllol
Trosolwyg
Aelod o’r Tîm Darganfod Cyffuriau, y Gwyddorau Fferyllol a Therapiwteg Arbrofol yn Ysgol Fferylliaeth a Gwyddorau Fferyllol Prifysgol Caerdydd
Rwy'n ymchwilydd cydweithredol iawn sy'n arwain ac yn cyfrannu at dimau rhyngddisgyblaethol o gydweithwyr gwyddonol a chlinigol o gefndir academaidd a chefndir masnachol, ac mae gennyf ddiddordeb angerddol mewn sicrhau bod ymchwil wyddonol yn cael effaith amlwg. Mae fy nghefndir addysgol a phroffesiynol ym maes fferylliaeth a’r gwyddorau fferyllol. Mae fy ngweithgareddau ymchwil presennol yn ymwneud â’r croen (fel organ a rhwystr) ac optimeiddio systemau cyflwyno cyffuriau arloesol.
- PhD (Cyflwyno Cyffuriau), Prifysgol Caerdydd, 2007
- MPharm, Prifysgol Cymru, Caerdydd, 2001
Cyhoeddiad
2023
- Potts, M. R., Evans, S. L., Pullin, R., Coulman, S. A., Birchall, J. C. and Wyatt, H. 2023. An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration. Computer Methods in Biomechanics and Biomedical Engineering 26(14), pp. 1719-1731. (10.1080/10255842.2022.2136486)
- Dul, M. et al. 2023. Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product. Journal of Controlled Release 361, pp. 236-245. (10.1016/j.jconrel.2023.07.001)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8(6), article number: 2100868. (10.1002/admt.202100868)
2022
- Al Dalaty, A., Gualeni, B., Coulman, S. A. and Birchall, J. C. 2022. Models and methods to characterise levonorgestrel release from intradermally administered contraceptives. Drug Delivery and Translational Research 12, pp. 335-349. (10.1007/s13346-021-01091-5)
- Tatovic, D. et al. 2022. Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in Type 1 diabetes. Immunotherapy Advances 2(1), article number: ltac002. (10.1093/immadv/ltac002)
2021
- Gualeni, B. et al. 2021. Human-centred design of a new microneedle-based hormonal contraceptive delivery system [version 2; peer review: 2 approved with reservations]. Gates Open Research 5, article number: 96. (10.12688/gatesopenres.13233.2)
- Singh, R. K. et al. 2021. Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides. Nanomedicine: Nanotechnology, Biology and Medicine 32, article number: 102321. (10.1016/j.nano.2020.102321)
2020
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
2019
- Dul, M. et al. 2019. Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy. International Journal of Pharmaceutics 562, pp. 303-312. (10.1016/j.ijpharm.2019.03.041)
2018
- Prytherch, Z. et al. 2018. Evaluation of student engagement with differential media for Flipped Classroom teaching. Presented at: EdMedia: World Conference on Educational Media and Technology, Amsterdam, 25-29 June 2018 Presented at Bastiaens, T. et al. eds.Proceedings of EdMedia: World Conference on Educational Media and Technology. Amsterdam, The Netherlands: Association for the Advancement of Computing in Education (AACE) pp. 1923-1928.
- Gualeni, B. et al. 2018. Minimally-invasive and targeted therapeutic cell delivery to the skin using microneedle devices. British Journal of Dermatology 178(3), pp. 731-739. (10.1111/bjd.15923)
- Davies, L., Gateley, C., Holland, P., Coulman, S. and Birchall, J. 2018. Accelerating topical anaesthesia using microneedles. Skin Pharmacology and Physiology 30(6), pp. 277-283. (10.1159/000479530)
2017
- Moreno, E. et al. 2017. Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp.. International Journal of Pharmaceutics 533(1), pp. 236-244. (10.1016/j.ijpharm.2017.09.055)
- McGrath, M., Coulman, S., Birchall, J. C. and Prausnitz, M. 2017. Editorial. Journal of Controlled Release 265, pp. 1-1. (10.1016/j.jconrel.2017.10.030)
- Dul, M. et al. 2017. Hydrodynamic gene delivery in human skin using a hollow microneedle device. Journal of Controlled Release 265, pp. 120-131. (10.1016/j.jconrel.2017.02.028)
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
- Jones, B., Ecenarro, S., Whiteside, B., Birchall, J. and Coulman, S. 2017. Imaging techniques for dry powder inhaler capsules. Inhalation
2016
- Shelvey, B., Coulman, S. and John, D. 2016. Evaluating an undergraduate interprofessional education session for medical and pharmacy undergraduates on therapeutics and prescribing: the medical student perspective. Advances in Medical Education and Practice 7, pp. 661-670. (10.2147/AMEP.S116618)
- Czubala, M. A. et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123)
- Chong, R. H., Jones, B., Díez, F., Birchall, J. C. and Coulman, S. 2016. Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers. International Journal of Pharmaceutics 500(1-2), pp. 316-325. (10.1016/j.ijpharm.2016.01.034)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
2015
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
- Alrakaf, S. et al. 2015. An international comparison study of pharmacy students’ achievement goals and their relationship to assessment type and scores. American Journal of Pharmaceutical Education 79(3), pp. 1-8. (10.5688/ajpe79335)
2014
- Griffiths, C. M., Mantzourani, E. D., Poole, R., Tranter, B., Coulman, S. and John, D. N. 2014. Exploring MPharm students’; opinion on a specialist cancer treatment hospital placement. International Journal of Pharmacy Practice 22(S2), pp. 96-97. (10.1111/ijpp.12146)
- Alrakaf, S. et al. 2014. An international validation study of two achievement goal measures in a pharmacy education context. Advances in Medical Education and Practice 2014(5), pp. 339-345. (10.2147/AMEP.S68241)
2013
- Chong, R. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211-219. (10.1016/j.jconrel.2012.12.030)
- Groves, R. B., Coulman, S., Birchall, J. C. and Evans, S. L. 2013. An anisotropic, hyperelastic model for skin: experimental measurements, finite element modelling and identification of parameters for human and murine skin. Journal of the Mechanical Behaviour of Biomedical Materials 18, pp. 167-180. (10.1016/j.jmbbm.2012.10.021)
- Torrisi, B. M., Zarnitsyn, V., Prausnitz, M. R., Anstey, A. V., Gateley, C., Birchall, J. C. and Coulman, S. 2013. Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin. Journal of Controlled Release 165(2), pp. 146-152. (10.1016/j.jconrel.2012.11.010)
- Torrisi, B. M., Birchall, J. C., Jones, B., Díez, F. and Coulman, S. 2013. The development of a sensitive methodology to characterise hard shell capsule puncture by dry powder inhaler pins. International Journal of Pharmaceutics 456(2), pp. 545-552. (10.1016/j.ijpharm.2013.08.011)
- Chong, R. H. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211. (10.1016/j.jconrel.2012.12.030)
2012
- Pearton, M., Saller, V., Coulman, S., Gateley, C., Anstey, A. V., Zarnitsyn, V. and Birchall, J. C. 2012. Microneedle delivery of plasmid DNA to living human skin: Formulation coating, skin insertion and gene expression. Journal of Controlled Release 160(3), pp. 561-569. (10.1016/j.jconrel.2012.04.005)
- Groves, R. B., Coulman, S., Birchall, J. C. and Evans, S. L. 2012. Quantifying the mechanical properties of human skin to optimise future microneedle device design. Computer Methods in Biomechanics and Biomedical Engineering 15(1), pp. 73-82. (10.1080/10255842.2011.596481)
2011
- Chong, R., Coulman, S., Saller, V., Pearton, M., Shah, A., Hargest, R. and Birchall, J. C. 2011. Nucleic acid delivery to skin for the potential treatment of dermatopathogenic conditions [Abstract]. Human Gene Therapy 22(10), pp. A82-A82.
- Smith, M. W., Birchall, J. C. and Coulman, S. 2011. The wider contribution of microbiology to the pharmaceutical sciences. In: Denver, S. P. et al. eds. Hugo and Russell's Pharmaceutical Microbiology 8th Edition. Wiley-Blackwell, pp. 463-482.
- Coulman, S. et al. 2011. In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharmaceutical Research 28(1), pp. 66-81. (10.1007/s11095-010-0167-x)
- Groves, R. B., Coulman, S., Birchall, J. C. and Evans, S. L. 2011. Using inverse finite element modeling to identify the anisotropic mechanical properties of human and mouse skin in tension. Presented at: International Conference on the Mechanics of Biomaterials and Tissues, Hawaii, USA, 11-15 December 2011.
2010
- Hughes, M. L., Lo, T., Coulman, S., Deslandes, R., Kell, C. and John, D. 2010. What makes a good lecturer? MPharm students’ views. International Journal of Pharmacy Practice 18(s1), pp. 29-30. (10.1111/j.2042-7174.2010.00027.x)
2009
- Ng, K. W. et al. 2009. Development of an ex vivo human skin model for intradermal vaccination: Tissue viability and Langerhans cell behaviour. Vaccine 27(43), pp. 5948-5955. (10.1016/j.vaccine.2009.07.088)
- Ng, K. W. et al. 2009. Tissue viability and Langerhans cell behaviour in an ex-vivo human skin model for cutaneous DNA vaccination [Abstract]. Journal of Pharmacy and Pharmacology 61(S1), pp. A1-A5. (10.1211/002235709789037044)
- Coulman, S. 2009. Targeting the delivery of proteins, DNA and vaccines to the skin [Abstract]. Journal of Pharmacy and Pharmacology 61(S1), pp. A146., article number: 201. (10.1211/002235709789037080)
- Coulman, S., Anstey, A. V., Gateley, C., Morrissey, A., McLoughlin, P., Allender, C. J. and Birchall, J. C. 2009. Microneedle mediated delivery of nanoparticles into human skin. International Journal of Pharmaceutics 366(1-2), pp. 190-200. (10.1016/j.ijpharm.2008.08.040)
- Ng, K. W. et al. 2009. Ex vivo immunological studies using excised human skin. British Journal Of Dermatology 160(4), pp. 921-921.
2006
- Birchall, J. C. et al. 2006. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation. International Journal of Pharmaceutics 312(1-2), pp. 15-23. (10.1016/j.ijpharm.2005.12.036)
- Coulman, S. et al. 2006. Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles. Current drug delivery 3(1), pp. 65-75.
- Coulman, S. A. 2006. Gene delivery to human skin using microneedle arrays. PhD Thesis, Cardiff University.
2005
- Birchall, J. C. et al. 2005. Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles. Journal of drug targeting 13(7), pp. 415-421. (10.1080/10611860500383705)
Articles
- Potts, M. R., Evans, S. L., Pullin, R., Coulman, S. A., Birchall, J. C. and Wyatt, H. 2023. An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration. Computer Methods in Biomechanics and Biomedical Engineering 26(14), pp. 1719-1731. (10.1080/10255842.2022.2136486)
- Dul, M. et al. 2023. Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product. Journal of Controlled Release 361, pp. 236-245. (10.1016/j.jconrel.2023.07.001)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8(6), article number: 2100868. (10.1002/admt.202100868)
- Al Dalaty, A., Gualeni, B., Coulman, S. A. and Birchall, J. C. 2022. Models and methods to characterise levonorgestrel release from intradermally administered contraceptives. Drug Delivery and Translational Research 12, pp. 335-349. (10.1007/s13346-021-01091-5)
- Tatovic, D. et al. 2022. Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in Type 1 diabetes. Immunotherapy Advances 2(1), article number: ltac002. (10.1093/immadv/ltac002)
- Gualeni, B. et al. 2021. Human-centred design of a new microneedle-based hormonal contraceptive delivery system [version 2; peer review: 2 approved with reservations]. Gates Open Research 5, article number: 96. (10.12688/gatesopenres.13233.2)
- Singh, R. K. et al. 2021. Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides. Nanomedicine: Nanotechnology, Biology and Medicine 32, article number: 102321. (10.1016/j.nano.2020.102321)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
- Dul, M. et al. 2019. Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy. International Journal of Pharmaceutics 562, pp. 303-312. (10.1016/j.ijpharm.2019.03.041)
- Gualeni, B. et al. 2018. Minimally-invasive and targeted therapeutic cell delivery to the skin using microneedle devices. British Journal of Dermatology 178(3), pp. 731-739. (10.1111/bjd.15923)
- Davies, L., Gateley, C., Holland, P., Coulman, S. and Birchall, J. 2018. Accelerating topical anaesthesia using microneedles. Skin Pharmacology and Physiology 30(6), pp. 277-283. (10.1159/000479530)
- Moreno, E. et al. 2017. Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp.. International Journal of Pharmaceutics 533(1), pp. 236-244. (10.1016/j.ijpharm.2017.09.055)
- McGrath, M., Coulman, S., Birchall, J. C. and Prausnitz, M. 2017. Editorial. Journal of Controlled Release 265, pp. 1-1. (10.1016/j.jconrel.2017.10.030)
- Dul, M. et al. 2017. Hydrodynamic gene delivery in human skin using a hollow microneedle device. Journal of Controlled Release 265, pp. 120-131. (10.1016/j.jconrel.2017.02.028)
- Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
- Jones, B., Ecenarro, S., Whiteside, B., Birchall, J. and Coulman, S. 2017. Imaging techniques for dry powder inhaler capsules. Inhalation
- Shelvey, B., Coulman, S. and John, D. 2016. Evaluating an undergraduate interprofessional education session for medical and pharmacy undergraduates on therapeutics and prescribing: the medical student perspective. Advances in Medical Education and Practice 7, pp. 661-670. (10.2147/AMEP.S116618)
- Czubala, M. A. et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. Journal of Investigative Dermatology 136(10), pp. 1981-1989. (10.1016/j.jid.2016.05.123)
- Chong, R. H., Jones, B., Díez, F., Birchall, J. C. and Coulman, S. 2016. Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers. International Journal of Pharmaceutics 500(1-2), pp. 316-325. (10.1016/j.ijpharm.2016.01.034)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
- Alrakaf, S. et al. 2015. An international comparison study of pharmacy students’ achievement goals and their relationship to assessment type and scores. American Journal of Pharmaceutical Education 79(3), pp. 1-8. (10.5688/ajpe79335)
- Griffiths, C. M., Mantzourani, E. D., Poole, R., Tranter, B., Coulman, S. and John, D. N. 2014. Exploring MPharm students’; opinion on a specialist cancer treatment hospital placement. International Journal of Pharmacy Practice 22(S2), pp. 96-97. (10.1111/ijpp.12146)
- Alrakaf, S. et al. 2014. An international validation study of two achievement goal measures in a pharmacy education context. Advances in Medical Education and Practice 2014(5), pp. 339-345. (10.2147/AMEP.S68241)
- Chong, R. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211-219. (10.1016/j.jconrel.2012.12.030)
- Groves, R. B., Coulman, S., Birchall, J. C. and Evans, S. L. 2013. An anisotropic, hyperelastic model for skin: experimental measurements, finite element modelling and identification of parameters for human and murine skin. Journal of the Mechanical Behaviour of Biomedical Materials 18, pp. 167-180. (10.1016/j.jmbbm.2012.10.021)
- Torrisi, B. M., Zarnitsyn, V., Prausnitz, M. R., Anstey, A. V., Gateley, C., Birchall, J. C. and Coulman, S. 2013. Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin. Journal of Controlled Release 165(2), pp. 146-152. (10.1016/j.jconrel.2012.11.010)
- Torrisi, B. M., Birchall, J. C., Jones, B., Díez, F. and Coulman, S. 2013. The development of a sensitive methodology to characterise hard shell capsule puncture by dry powder inhaler pins. International Journal of Pharmaceutics 456(2), pp. 545-552. (10.1016/j.ijpharm.2013.08.011)
- Chong, R. H. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211. (10.1016/j.jconrel.2012.12.030)
- Pearton, M., Saller, V., Coulman, S., Gateley, C., Anstey, A. V., Zarnitsyn, V. and Birchall, J. C. 2012. Microneedle delivery of plasmid DNA to living human skin: Formulation coating, skin insertion and gene expression. Journal of Controlled Release 160(3), pp. 561-569. (10.1016/j.jconrel.2012.04.005)
- Groves, R. B., Coulman, S., Birchall, J. C. and Evans, S. L. 2012. Quantifying the mechanical properties of human skin to optimise future microneedle device design. Computer Methods in Biomechanics and Biomedical Engineering 15(1), pp. 73-82. (10.1080/10255842.2011.596481)
- Chong, R., Coulman, S., Saller, V., Pearton, M., Shah, A., Hargest, R. and Birchall, J. C. 2011. Nucleic acid delivery to skin for the potential treatment of dermatopathogenic conditions [Abstract]. Human Gene Therapy 22(10), pp. A82-A82.
- Coulman, S. et al. 2011. In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharmaceutical Research 28(1), pp. 66-81. (10.1007/s11095-010-0167-x)
- Hughes, M. L., Lo, T., Coulman, S., Deslandes, R., Kell, C. and John, D. 2010. What makes a good lecturer? MPharm students’ views. International Journal of Pharmacy Practice 18(s1), pp. 29-30. (10.1111/j.2042-7174.2010.00027.x)
- Ng, K. W. et al. 2009. Development of an ex vivo human skin model for intradermal vaccination: Tissue viability and Langerhans cell behaviour. Vaccine 27(43), pp. 5948-5955. (10.1016/j.vaccine.2009.07.088)
- Ng, K. W. et al. 2009. Tissue viability and Langerhans cell behaviour in an ex-vivo human skin model for cutaneous DNA vaccination [Abstract]. Journal of Pharmacy and Pharmacology 61(S1), pp. A1-A5. (10.1211/002235709789037044)
- Coulman, S. 2009. Targeting the delivery of proteins, DNA and vaccines to the skin [Abstract]. Journal of Pharmacy and Pharmacology 61(S1), pp. A146., article number: 201. (10.1211/002235709789037080)
- Coulman, S., Anstey, A. V., Gateley, C., Morrissey, A., McLoughlin, P., Allender, C. J. and Birchall, J. C. 2009. Microneedle mediated delivery of nanoparticles into human skin. International Journal of Pharmaceutics 366(1-2), pp. 190-200. (10.1016/j.ijpharm.2008.08.040)
- Ng, K. W. et al. 2009. Ex vivo immunological studies using excised human skin. British Journal Of Dermatology 160(4), pp. 921-921.
- Birchall, J. C. et al. 2006. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation. International Journal of Pharmaceutics 312(1-2), pp. 15-23. (10.1016/j.ijpharm.2005.12.036)
- Coulman, S. et al. 2006. Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles. Current drug delivery 3(1), pp. 65-75.
- Birchall, J. C. et al. 2005. Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles. Journal of drug targeting 13(7), pp. 415-421. (10.1080/10611860500383705)
Book sections
- Smith, M. W., Birchall, J. C. and Coulman, S. 2011. The wider contribution of microbiology to the pharmaceutical sciences. In: Denver, S. P. et al. eds. Hugo and Russell's Pharmaceutical Microbiology 8th Edition. Wiley-Blackwell, pp. 463-482.
Conferences
- Prytherch, Z. et al. 2018. Evaluation of student engagement with differential media for Flipped Classroom teaching. Presented at: EdMedia: World Conference on Educational Media and Technology, Amsterdam, 25-29 June 2018 Presented at Bastiaens, T. et al. eds.Proceedings of EdMedia: World Conference on Educational Media and Technology. Amsterdam, The Netherlands: Association for the Advancement of Computing in Education (AACE) pp. 1923-1928.
- Groves, R. B., Coulman, S., Birchall, J. C. and Evans, S. L. 2011. Using inverse finite element modeling to identify the anisotropic mechanical properties of human and mouse skin in tension. Presented at: International Conference on the Mechanics of Biomaterials and Tissues, Hawaii, USA, 11-15 December 2011.
Thesis
- Coulman, S. A. 2006. Gene delivery to human skin using microneedle arrays. PhD Thesis, Cardiff University.
Ymchwil
Diddordebau ymchwil
- Y croen fel targed a phorth ar gyfer cyflenwi cyffuriau
- Dyfeisiau micronodwydd
- Mewnanadlyddion powdwr sych sy'n seiliedig ar gapsiwl (DPIs)
- Y rhyngwyneb defnyddiwr-dyfais
- Bio-argraffu croen dynol
- Cyfrifiadau sy'n seiliedig ar rifedd a meddyginiaethau (ymchwil Addysgeg)
Gellir categoreiddio fy ngweithgareddau ymchwil gwyddonol a'm harbenigedd yn fras yn dair ffrwd waith, pob un ohonynt yn gysylltiedig â'r croen (fel organ a rhwystr i gyflenwi cyffuriau) a / neu optimeiddio systemau cyflenwi cyffuriau arloesol.
Rwyf wedi gweithio gyda dyfeisiau micronodwydd ers 2002, gan archwilio eu potensial fel dull lleiaf ymledol ar gyfer cyflwyno cynhwysion fferyllol gweithredol newydd a sefydledig yn draws-dermol a mewn-dermol, gan gynnwys ystod o fiolegau a brechlynnau. Mae gen i ffocws penodol ar gyfieithu technoleg o brototeipiau labordy i gynhyrchion clinigol defnyddiol a masnachol. Rwyf wedi cyfrannu at amrywiaeth o brosiectau ac mae gennyf brofiad technegol sylweddol wrth werthuso systemau cyflenwi mewn-dermaidd a thraws-dermaidd yn flaenorol vivo ac in vivo. Mae fy arbenigedd a'm cyhoeddiadau yn cynnwys defnyddio dulliau arloesol i werthuso biomecaneg croen dynol, pensaernïaeth meinwe ac imiwnoleg leol, yn ogystal ag astudiaethau defnyddwyr. Rwy'n gyd-sylfaenydd Extraject technologies, sy'n deillio o Brifysgol Caerdydd, sy'n ceisio masnacheiddio systemau minimally invasive ar gyfer therapi celloedd yn y croen, ac rwy'n gyd-Gadeirydd Gweithgor Gweithio (Microneedle Array Patch - Regulatory WorkGroup; MAP-RWG), a gychwynnwyd yn 2018, ac a sefydlwyd yn 2019, i helpu i ddiffinio'r llwybr rheoleiddio ar gyfer y ffurflen dos hon ac hwyluso cyfieithu clinigol o'r dechnoleg.
Rwyf hefyd yn gweithio'n agos gyda Pharma rhyngwladol mawr i werthuso perfformiad cynhyrchion capsiwl sefydledig ac arloesol i'w defnyddio mewnmewnanadlyddion powdr sych (DPIs) seiliedig ar apsule . Cynorthwyais i ddatblygu methodoleg profi in vitro ar gyfer capsiwlau sydd wedi, ac sy'n parhau i gael eu defnyddio, gan y diwydiant fferyllol ar gyfer datblygu cynnyrch a sicrhau ansawdd. Fy nod yw deall a gwella perfformiad DPI yn y labordy ac yn nwylo'r defnyddiwr.
Fy nhrydydd maes diddordeb yw bioargraffu 3D ac, yn fwy penodol, datblygu model croen gan ddefnyddio platfform bioargraffu 3D fforddiadwy a masnachol sydd ar gael. Mae'r maes ymchwil hynod arloesol hwn wedi ysgogi diddordeb gwyddonol a chyhoeddus sylweddol, sydd wedi hwyluso nifer o gyfleoedd ymgysylltu.
Mae gen i ddiddordeb addysgeg hefyd mewn cyfrifiadau rhifedd a meddyginiaethau, gyda ffocws penodol ar addysg myfyrwyr fferylliaeth a fferyllwyr yn y maes hwn. Rwyf wedi datblygu prawf rhifedd diagnostig cyd-destunol sydd wedi'i ddefnyddio mewn nifer o Ysgolion Fferylliaeth y DU ac wedi cyfrannu at weithgareddau sydd wedi llywio addysg a hyfforddiant myfyrwyr fferylliaeth a meddygol yn uniongyrchol.
Addysgu
- PH1000 Datblygiad Proffesiynol
- PH1122 Rôl y Fferyllydd mewn Ymarfer Proffesiynol
- PH1124 Systemau’r Corff Dynol
- PH2000 Datblygiad Proffesiynol
- PH2107 Gwyddoniaeth Fformiwleiddio
- PH3000 Datblygiad Proffesiynol
- PH3110 Optimeiddio Gofal Fferyllol
- PH3202 Methodoleg Ymchwil
- PH4000 Datblygiad Proffesiynol
- PH4116 Prosiect ysgoloriaeth neu ymchwil ym maes fferylliaeth
- PH4118 Gwyddorau Fferyllol, Ymarfer Fferyllol a’r Claf
Arweinydd Asesiadau ac Adborth yr Ysgol Fferylliaeth a Gwyddorau Fferyllol
Arweinydd Cyfrifiadau Fferyllol yr Ysgol Fferylliaeth a Gwyddorau Fferyllol
Bywgraffiad
Proffil gyrfa
Graddiais o Brifysgol Cymru, Caerdydd yn 2001 gyda gradd MPharm ac yna symudais i fy mlwyddyn cyn-gofrestru mewn fferylliaeth gymunedol. Yn ystod haf 2002 deuthum yn aelod o'r Gymdeithas Fferyllol Frenhinol Prydain Fawr a dechreuais ymarfer proffesiynol fel fferyllydd locwm, gan weithio'n rhan-amser yn y sector cymunedol.
Roedd hyn yn cyd-daro â dechrau fy astudiaethau PhD ym Mhrifysgol Caerdydd lle treuliais dair blynedd yn ymchwilio i systemau cyflenwi trawsdermaidd newydd ar gyfer cyflwyno a mynegi DNA plasmid allgenaidd mewn croen dynol. Yn 2005, wrth gwblhau fy astudiaethau PhD, dechreuais gontract byr ym Mhrifysgol Caerdydd fel Cymrawd Addysgu ac yn ystod y cyfnod hwn datblygais fy niddordeb addysgeg mewn cyfrifiadau rhifedd a meddygaeth sy'n seiliedig ar fathemateg, sy'n faes dysgu ac addysgu rwy'n parhau i fod yn angerddol amdano.
Yn ystod haf 2006, ar ôl graddio gyda fy PhD, cymerais Ddarlithyddiaeth yn Ysgol Fferylliaeth Caerdydd ac ers hynny rwyf wedi cael fy mhenodi'n Uwch-ddarlithydd (2014), ac yn awr yn Ddarllenydd (2023). Rwy'n parhau i weithio'n angerddol ar systemau cyflenwi cyffuriau sy'n seiliedig ar ficronodwydd ar gyfer darparu brechlynnau, biologics a nanoronynnau i'r croen. Fodd bynnag, yn ystod y degawd diwethaf rwyf hefyd wedi gweithio'n agos gyda'r diwydiant fferyllol i ddatblygu mewnanadlyddion powdr sych (DPIs) sy'n seiliedig ar gapsiwl ar gyfer cyflenwi cyffuriau ysgyfeiniol, ac yn 2015 dechreuais weithio ar adeiladu bio-argraffydd i greu modelau croen dynol ar gyfer y labordy.
Rwy'n ymchwilydd cydweithredol iawn sydd bob amser wedi gwerthfawrogi perthnasoedd rhyngddisgyblaethol â chydweithwyr o sefydliadau academaidd, diwydiant, cyrff rheoleiddio a sefydliadau anllywodraethol. Rwy'n mwynhau rolau fel aelod o bwyllgor Cymdeithas Rhyddhau Rheoledig y Deyrnas Unedig ac Iwerddon (UKICRS®) (ers 2013) a chyd-Gadeirydd y Microneedle Array Patch - Regulatory Working Group (MAP-RWG) (ers 2018).
Aelodaethau proffesiynol
- Gweithgor Patch-Rheoleiddio Array Microneedle (MAP-RWG)
- Cymdeithas Rhyddhau Rheoledig y Deyrnas Unedig ac Iwerddon (UKICRS)
- Aelod o Sefydliad Peirianneg a Thrwsio Meinwe Caerdydd (CITER)
- Llysgennad STEM
- Cyngor Fferyllol Cyffredinol
- Aelod o'r Cyngor Fferyllol Cyffredinol (GPhC) (2002-2018)
Pwyllgorau ac adolygu
- Cyd-gadeirydd Gweithgor Patch-Regulatory Array Microneedle (MAP-RWG) (2019 - presennol)
- Aelod o'r Pwyllgor Llywio ar gyfer y Gynhadledd Ryngwladol ar Micronodwyddau (2016 - presennol); Cyd-gynnal y Gynhadledd Ryngwladol ar Micronodwyddau 2016
- Aelod o'r Pwyllgor dros Gymdeithas Rhyddhau Rheoledig y DU ac Iwerddon (UKICRS) (2013 - presennol
