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Dr Sion Coulman
Timau a rolau for Sion Coulman
Darllenydd mewn Fferylliaeth a Gwyddorau Fferyllol
Trosolwyg
Aelod o’r Tîm Darganfod Cyffuriau, y Gwyddorau Fferyllol a Therapiwteg Arbrofol yn Ysgol Fferylliaeth a Gwyddorau Fferyllol Prifysgol Caerdydd
Rwy'n ymchwilydd cydweithredol iawn sy'n arwain ac yn cyfrannu at dimau rhyngddisgyblaethol o gydweithwyr gwyddonol a chlinigol o gefndir academaidd a chefndir masnachol, ac mae gennyf ddiddordeb angerddol mewn sicrhau bod ymchwil wyddonol yn cael effaith amlwg. Mae fy nghefndir addysgol a phroffesiynol ym maes fferylliaeth a’r gwyddorau fferyllol. Mae fy ngweithgareddau ymchwil presennol yn ymwneud â’r croen (fel organ a rhwystr) ac optimeiddio systemau cyflwyno cyffuriau arloesol.
- PhD (Cyflwyno Cyffuriau), Prifysgol Caerdydd, 2007
- MPharm, Prifysgol Cymru, Caerdydd, 2001
Cyhoeddiad
2025
- Bocchino, A. et al., 2025. A multifunctional platform for the production and customization of polymer-based microneedle devices. Sensors and Actuators A: Physical 388 116491. (10.1016/j.sna.2025.116491)
- Dul, M. et al. 2025. White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin. Journal of Controlled Release 378 , pp.402-415. (10.1016/j.jconrel.2024.11.056)
2023
- Potts, M. R. et al. 2023. An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration. Computer Methods in Biomechanics and Biomedical Engineering 26 (14), pp.1719-1731. (10.1080/10255842.2022.2136486)
- Dul, M. et al. 2023. Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product. Journal of Controlled Release 361 , pp.236-245. (10.1016/j.jconrel.2023.07.001)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8 (6) 2100868. (10.1002/admt.202100868)
2022
- Al Dalaty, A. et al. 2022. Models and methods to characterise levonorgestrel release from intradermally administered contraceptives. Drug Delivery and Translational Research 12 , pp.335-349. (10.1007/s13346-021-01091-5)
- Tatovic, D. et al. 2022. Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in Type 1 diabetes. Immunotherapy Advances 2 (1) ltac002. (10.1093/immadv/ltac002)
2021
- Gualeni, B. et al. 2021. Human-centred design of a new microneedle-based hormonal contraceptive delivery system [version 2; peer review: 2 approved with reservations]. Gates Open Research 5 96. (10.12688/gatesopenres.13233.2)
- Singh, R. K. et al. 2021. Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides. Nanomedicine: Nanotechnology, Biology and Medicine 32 102321. (10.1016/j.nano.2020.102321)
2020
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322 , pp.593-601. (10.1016/j.jconrel.2020.02.031)
2019
- Dul, M. et al. 2019. Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy. International Journal of Pharmaceutics 562 , pp.303-312. (10.1016/j.ijpharm.2019.03.041)
2018
- Prytherch, Z. et al. 2018. Evaluation of student engagement with differential media for Flipped Classroom teaching. Presented at: EdMedia: World Conference on Educational Media and Technology Amsterdam 25-29 June 2018. Published in: Bastiaens, T. et al., Proceedings of EdMedia: World Conference on Educational Media and Technology. Amsterdam, The Netherlands: Association for the Advancement of Computing in Education (AACE). , pp.1923-1928.
- Gualeni, B. et al. 2018. Minimally-invasive and targeted therapeutic cell delivery to the skin using microneedle devices. British Journal of Dermatology 178 (3), pp.731-739. (10.1111/bjd.15923)
- Davies, L. et al. 2018. Accelerating topical anaesthesia using microneedles. Skin Pharmacology and Physiology 30 (6), pp.277-283. (10.1159/000479530)
2017
- Moreno, E. et al., 2017. Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp.. International Journal of Pharmaceutics 533 (1), pp.236-244. (10.1016/j.ijpharm.2017.09.055)
- Dul, M. et al. 2017. Hydrodynamic gene delivery in human skin using a hollow microneedle device. Journal of Controlled Release 265 , pp.120-131. (10.1016/j.jconrel.2017.02.028)
- McGrath, M. et al., 2017. Editorial. Journal of Controlled Release 265 , pp.1-1. (10.1016/j.jconrel.2017.10.030)
- Zhao, X. et al. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265 , pp.2-13. (10.1016/j.jconrel.2017.03.015)
- Jones, B. et al. 2017. Imaging techniques for dry powder inhaler capsules. Inhalation
2016
- Shelvey, B. , Coulman, S. and John, D. 2016. Evaluating an undergraduate interprofessional education session for medical and pharmacy undergraduates on therapeutics and prescribing: the medical student perspective. Advances in Medical Education and Practice 7 , pp.661-670. (10.2147/AMEP.S116618)
- Czubala, M. A. et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. Journal of Investigative Dermatology 136 (10), pp.1981-1989. (10.1016/j.jid.2016.05.123)
- Chong, R. H. et al. 2016. Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers. International Journal of Pharmaceutics 500 (1-2), pp.316-325. (10.1016/j.ijpharm.2016.01.034)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223 , pp.178-187. (10.1016/j.jconrel.2015.12.040)
2015
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146 (3), pp.411-422. (10.1111/imm.12518)
- Alrakaf, S. et al., 2015. An international comparison study of pharmacy students’ achievement goals and their relationship to assessment type and scores. American Journal of Pharmaceutical Education 79 (3), pp.1-8. (10.5688/ajpe79335)
2014
- Alrakaf, S. et al., 2014. An international validation study of two achievement goal measures in a pharmacy education context. Advances in Medical Education and Practice 2014 (5), pp.339-345. (10.2147/AMEP.S68241)
- Griffiths, C. M. et al. 2014. Exploring MPharm students’; opinion on a specialist cancer treatment hospital placement. International Journal of Pharmacy Practice 22 (S2), pp.96-97. (10.1111/ijpp.12146)
2013
- Chong, R. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166 (3), pp.211-219. (10.1016/j.jconrel.2012.12.030)
- Groves, R. B. et al. 2013. An anisotropic, hyperelastic model for skin: experimental measurements, finite element modelling and identification of parameters for human and murine skin. Journal of the Mechanical Behaviour of Biomedical Materials 18 , pp.167-180. (10.1016/j.jmbbm.2012.10.021)
- Torrisi, B. M. et al. 2013. The development of a sensitive methodology to characterise hard shell capsule puncture by dry powder inhaler pins. International Journal of Pharmaceutics 456 (2), pp.545-552. (10.1016/j.ijpharm.2013.08.011)
- Torrisi, B. M. et al. 2013. Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin. Journal of Controlled Release 165 (2), pp.146-152. (10.1016/j.jconrel.2012.11.010)
2012
- Groves, R. B. et al. 2012. Quantifying the mechanical properties of human skin to optimise future microneedle device design. Computer Methods in Biomechanics and Biomedical Engineering 15 (1), pp.73-82. (10.1080/10255842.2011.596481)
- Pearton, M. et al. 2012. Microneedle delivery of plasmid DNA to living human skin: Formulation coating, skin insertion and gene expression. Journal of Controlled Release 160 (3), pp.561-569. (10.1016/j.jconrel.2012.04.005)
2011
- Chong, R. et al. 2011. Nucleic acid delivery to skin for the potential treatment of dermatopathogenic conditions [Abstract]. Human Gene Therapy 22 (10), pp.A82-A82.
- Coulman, S. et al. 2011. In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharmaceutical Research 28 (1), pp.66-81. (10.1007/s11095-010-0167-x)
- Groves, R. B. et al. 2011. Using inverse finite element modeling to identify the anisotropic mechanical properties of human and mouse skin in tension. Presented at: International Conference on the Mechanics of Biomaterials and Tissues Hawaii, USA 11-15 December 2011.
- Smith, M. W. , Birchall, J. C. and Coulman, S. 2011. The wider contribution of microbiology to the pharmaceutical sciences. In: Denver, S. P. et al., Hugo and Russell's Pharmaceutical Microbiology 8th Edition. Wiley-Blackwell. , pp.463-482.
2010
- Hughes, M. L. et al. 2010. What makes a good lecturer? MPharm students’ views. International Journal of Pharmacy Practice 18 (s1), pp.29-30. (10.1111/j.2042-7174.2010.00027.x)
2009
- Ng, K. W. et al. 2009. Development of an ex vivo human skin model for intradermal vaccination: Tissue viability and Langerhans cell behaviour. Vaccine 27 (43), pp.5948-5955. (10.1016/j.vaccine.2009.07.088)
- Ng, K. W. et al. 2009. Tissue viability and Langerhans cell behaviour in an ex-vivo human skin model for cutaneous DNA vaccination [Abstract]. Journal of Pharmacy and Pharmacology 61 (S1), pp.A1-A5. (10.1211/002235709789037044)
- Coulman, S. et al. 2009. Microneedle mediated delivery of nanoparticles into human skin. International Journal of Pharmaceutics 366 (1-2), pp.190-200. (10.1016/j.ijpharm.2008.08.040)
- Coulman, S. 2009. Targeting the delivery of proteins, DNA and vaccines to the skin [Abstract]. Journal of Pharmacy and Pharmacology 61 (S1), pp.A146. 201. (10.1211/002235709789037080)
- Ng, K. W. et al. 2009. Ex vivo immunological studies using excised human skin. British Journal Of Dermatology 160 (4), pp.921-921.
2006
- Birchall, J. C. et al. 2006. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation. International Journal of Pharmaceutics 312 (1-2), pp.15-23. (10.1016/j.ijpharm.2005.12.036)
- Coulman, S. et al. 2006. Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles. Current drug delivery 3 (1), pp.65-75.
- Coulman, S. A. 2006. Gene delivery to human skin using microneedle arrays. PhD Thesis , Cardiff University.
2005
- Birchall, J. C. et al. 2005. Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles. Journal of drug targeting 13 (7), pp.415-421. (10.1080/10611860500383705)
Adrannau llyfrau
- Smith, M. W. , Birchall, J. C. and Coulman, S. 2011. The wider contribution of microbiology to the pharmaceutical sciences. In: Denver, S. P. et al., Hugo and Russell's Pharmaceutical Microbiology 8th Edition. Wiley-Blackwell. , pp.463-482.
Cynadleddau
- Prytherch, Z. et al. 2018. Evaluation of student engagement with differential media for Flipped Classroom teaching. Presented at: EdMedia: World Conference on Educational Media and Technology Amsterdam 25-29 June 2018. Published in: Bastiaens, T. et al., Proceedings of EdMedia: World Conference on Educational Media and Technology. Amsterdam, The Netherlands: Association for the Advancement of Computing in Education (AACE). , pp.1923-1928.
- Groves, R. B. et al. 2011. Using inverse finite element modeling to identify the anisotropic mechanical properties of human and mouse skin in tension. Presented at: International Conference on the Mechanics of Biomaterials and Tissues Hawaii, USA 11-15 December 2011.
Erthyglau
- Bocchino, A. et al., 2025. A multifunctional platform for the production and customization of polymer-based microneedle devices. Sensors and Actuators A: Physical 388 116491. (10.1016/j.sna.2025.116491)
- Dul, M. et al. 2025. White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin. Journal of Controlled Release 378 , pp.402-415. (10.1016/j.jconrel.2024.11.056)
- Potts, M. R. et al. 2023. An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration. Computer Methods in Biomechanics and Biomedical Engineering 26 (14), pp.1719-1731. (10.1080/10255842.2022.2136486)
- Dul, M. et al. 2023. Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product. Journal of Controlled Release 361 , pp.236-245. (10.1016/j.jconrel.2023.07.001)
- Moukachar, A. et al. 2023. Development and evaluation of a low‐cost lego 3d bioprinter: from building‐blocks to building blocks of life. Advanced Materials Technologies 8 (6) 2100868. (10.1002/admt.202100868)
- Al Dalaty, A. et al. 2022. Models and methods to characterise levonorgestrel release from intradermally administered contraceptives. Drug Delivery and Translational Research 12 , pp.335-349. (10.1007/s13346-021-01091-5)
- Tatovic, D. et al. 2022. Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in Type 1 diabetes. Immunotherapy Advances 2 (1) ltac002. (10.1093/immadv/ltac002)
- Gualeni, B. et al. 2021. Human-centred design of a new microneedle-based hormonal contraceptive delivery system [version 2; peer review: 2 approved with reservations]. Gates Open Research 5 96. (10.12688/gatesopenres.13233.2)
- Singh, R. K. et al. 2021. Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides. Nanomedicine: Nanotechnology, Biology and Medicine 32 102321. (10.1016/j.nano.2020.102321)
- Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322 , pp.593-601. (10.1016/j.jconrel.2020.02.031)
- Dul, M. et al. 2019. Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy. International Journal of Pharmaceutics 562 , pp.303-312. (10.1016/j.ijpharm.2019.03.041)
- Gualeni, B. et al. 2018. Minimally-invasive and targeted therapeutic cell delivery to the skin using microneedle devices. British Journal of Dermatology 178 (3), pp.731-739. (10.1111/bjd.15923)
- Davies, L. et al. 2018. Accelerating topical anaesthesia using microneedles. Skin Pharmacology and Physiology 30 (6), pp.277-283. (10.1159/000479530)
- Moreno, E. et al., 2017. Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp.. International Journal of Pharmaceutics 533 (1), pp.236-244. (10.1016/j.ijpharm.2017.09.055)
- Dul, M. et al. 2017. Hydrodynamic gene delivery in human skin using a hollow microneedle device. Journal of Controlled Release 265 , pp.120-131. (10.1016/j.jconrel.2017.02.028)
- McGrath, M. et al., 2017. Editorial. Journal of Controlled Release 265 , pp.1-1. (10.1016/j.jconrel.2017.10.030)
- Zhao, X. et al. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265 , pp.2-13. (10.1016/j.jconrel.2017.03.015)
- Jones, B. et al. 2017. Imaging techniques for dry powder inhaler capsules. Inhalation
- Shelvey, B. , Coulman, S. and John, D. 2016. Evaluating an undergraduate interprofessional education session for medical and pharmacy undergraduates on therapeutics and prescribing: the medical student perspective. Advances in Medical Education and Practice 7 , pp.661-670. (10.2147/AMEP.S116618)
- Czubala, M. A. et al. 2016. TGFβ induces a SAMHD1-independent post-entry restriction to HIV-1 infection of human epithelial Langerhans cells. Journal of Investigative Dermatology 136 (10), pp.1981-1989. (10.1016/j.jid.2016.05.123)
- Chong, R. H. et al. 2016. Evaluating the sensitivity, reproducibility and flexibility of a method to test hard shell capsules intended for use in dry powder inhalers. International Journal of Pharmaceutics 500 (1-2), pp.316-325. (10.1016/j.ijpharm.2016.01.034)
- Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223 , pp.178-187. (10.1016/j.jconrel.2015.12.040)
- Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146 (3), pp.411-422. (10.1111/imm.12518)
- Alrakaf, S. et al., 2015. An international comparison study of pharmacy students’ achievement goals and their relationship to assessment type and scores. American Journal of Pharmaceutical Education 79 (3), pp.1-8. (10.5688/ajpe79335)
- Alrakaf, S. et al., 2014. An international validation study of two achievement goal measures in a pharmacy education context. Advances in Medical Education and Practice 2014 (5), pp.339-345. (10.2147/AMEP.S68241)
- Griffiths, C. M. et al. 2014. Exploring MPharm students’; opinion on a specialist cancer treatment hospital placement. International Journal of Pharmacy Practice 22 (S2), pp.96-97. (10.1111/ijpp.12146)
- Chong, R. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166 (3), pp.211-219. (10.1016/j.jconrel.2012.12.030)
- Groves, R. B. et al. 2013. An anisotropic, hyperelastic model for skin: experimental measurements, finite element modelling and identification of parameters for human and murine skin. Journal of the Mechanical Behaviour of Biomedical Materials 18 , pp.167-180. (10.1016/j.jmbbm.2012.10.021)
- Torrisi, B. M. et al. 2013. The development of a sensitive methodology to characterise hard shell capsule puncture by dry powder inhaler pins. International Journal of Pharmaceutics 456 (2), pp.545-552. (10.1016/j.ijpharm.2013.08.011)
- Torrisi, B. M. et al. 2013. Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin. Journal of Controlled Release 165 (2), pp.146-152. (10.1016/j.jconrel.2012.11.010)
- Groves, R. B. et al. 2012. Quantifying the mechanical properties of human skin to optimise future microneedle device design. Computer Methods in Biomechanics and Biomedical Engineering 15 (1), pp.73-82. (10.1080/10255842.2011.596481)
- Pearton, M. et al. 2012. Microneedle delivery of plasmid DNA to living human skin: Formulation coating, skin insertion and gene expression. Journal of Controlled Release 160 (3), pp.561-569. (10.1016/j.jconrel.2012.04.005)
- Chong, R. et al. 2011. Nucleic acid delivery to skin for the potential treatment of dermatopathogenic conditions [Abstract]. Human Gene Therapy 22 (10), pp.A82-A82.
- Coulman, S. et al. 2011. In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharmaceutical Research 28 (1), pp.66-81. (10.1007/s11095-010-0167-x)
- Hughes, M. L. et al. 2010. What makes a good lecturer? MPharm students’ views. International Journal of Pharmacy Practice 18 (s1), pp.29-30. (10.1111/j.2042-7174.2010.00027.x)
- Ng, K. W. et al. 2009. Development of an ex vivo human skin model for intradermal vaccination: Tissue viability and Langerhans cell behaviour. Vaccine 27 (43), pp.5948-5955. (10.1016/j.vaccine.2009.07.088)
- Ng, K. W. et al. 2009. Tissue viability and Langerhans cell behaviour in an ex-vivo human skin model for cutaneous DNA vaccination [Abstract]. Journal of Pharmacy and Pharmacology 61 (S1), pp.A1-A5. (10.1211/002235709789037044)
- Coulman, S. et al. 2009. Microneedle mediated delivery of nanoparticles into human skin. International Journal of Pharmaceutics 366 (1-2), pp.190-200. (10.1016/j.ijpharm.2008.08.040)
- Coulman, S. 2009. Targeting the delivery of proteins, DNA and vaccines to the skin [Abstract]. Journal of Pharmacy and Pharmacology 61 (S1), pp.A146. 201. (10.1211/002235709789037080)
- Ng, K. W. et al. 2009. Ex vivo immunological studies using excised human skin. British Journal Of Dermatology 160 (4), pp.921-921.
- Birchall, J. C. et al. 2006. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation. International Journal of Pharmaceutics 312 (1-2), pp.15-23. (10.1016/j.ijpharm.2005.12.036)
- Coulman, S. et al. 2006. Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles. Current drug delivery 3 (1), pp.65-75.
- Birchall, J. C. et al. 2005. Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles. Journal of drug targeting 13 (7), pp.415-421. (10.1080/10611860500383705)
Gosodiad
- Coulman, S. A. 2006. Gene delivery to human skin using microneedle arrays. PhD Thesis , Cardiff University.
Ymchwil
Diddordebau ymchwil
- Y croen fel targed a phorth ar gyfer cyflenwi cyffuriau
- Dyfeisiau micronodwydd
- Mewnanadlyddion powdwr sych sy'n seiliedig ar gapsiwl (DPIs)
- Y rhyngwyneb defnyddiwr-dyfais
- Bio-argraffu croen dynol
- Cyfrifiadau sy'n seiliedig ar rifedd a meddyginiaethau (ymchwil Addysgeg)
Gellir categoreiddio fy ngweithgareddau ymchwil gwyddonol a'm harbenigedd yn fras yn dair ffrwd waith, pob un ohonynt yn gysylltiedig â'r croen (fel organ a rhwystr i gyflenwi cyffuriau) a / neu optimeiddio systemau cyflenwi cyffuriau arloesol.
Rwyf wedi gweithio gyda dyfeisiau micronodwydd ers 2002, gan archwilio eu potensial fel dull lleiaf ymledol ar gyfer cyflwyno cynhwysion fferyllol gweithredol newydd a sefydledig yn draws-dermol a mewn-dermol, gan gynnwys ystod o fiolegau a brechlynnau. Mae gen i ffocws penodol ar gyfieithu technoleg o brototeipiau labordy i gynhyrchion clinigol defnyddiol a masnachol. Rwyf wedi cyfrannu at amrywiaeth o brosiectau ac mae gennyf brofiad technegol sylweddol wrth werthuso systemau cyflenwi mewn-dermaidd a thraws-dermaidd yn flaenorol vivo ac in vivo. Mae fy arbenigedd a'm cyhoeddiadau yn cynnwys defnyddio dulliau arloesol i werthuso biomecaneg croen dynol, pensaernïaeth meinwe ac imiwnoleg leol, yn ogystal ag astudiaethau defnyddwyr. Rwy'n gyd-sylfaenydd Extraject technologies, sy'n deillio o Brifysgol Caerdydd, sy'n ceisio masnacheiddio systemau minimally invasive ar gyfer therapi celloedd yn y croen, ac rwy'n gyd-Gadeirydd Gweithgor Gweithio (Microneedle Array Patch - Regulatory WorkGroup; MAP-RWG), a gychwynnwyd yn 2018, ac a sefydlwyd yn 2019, i helpu i ddiffinio'r llwybr rheoleiddio ar gyfer y ffurflen dos hon ac hwyluso cyfieithu clinigol o'r dechnoleg.
Rwyf hefyd yn gweithio'n agos gyda Pharma rhyngwladol mawr i werthuso perfformiad cynhyrchion capsiwl sefydledig ac arloesol i'w defnyddio mewnmewnanadlyddion powdr sych (DPIs) seiliedig ar apsule . Cynorthwyais i ddatblygu methodoleg profi in vitro ar gyfer capsiwlau sydd wedi, ac sy'n parhau i gael eu defnyddio, gan y diwydiant fferyllol ar gyfer datblygu cynnyrch a sicrhau ansawdd. Fy nod yw deall a gwella perfformiad DPI yn y labordy ac yn nwylo'r defnyddiwr.
Fy nhrydydd maes diddordeb yw bioargraffu 3D ac, yn fwy penodol, datblygu model croen gan ddefnyddio platfform bioargraffu 3D fforddiadwy a masnachol sydd ar gael. Mae'r maes ymchwil hynod arloesol hwn wedi ysgogi diddordeb gwyddonol a chyhoeddus sylweddol, sydd wedi hwyluso nifer o gyfleoedd ymgysylltu.
Mae gen i ddiddordeb addysgeg hefyd mewn cyfrifiadau rhifedd a meddyginiaethau, gyda ffocws penodol ar addysg myfyrwyr fferylliaeth a fferyllwyr yn y maes hwn. Rwyf wedi datblygu prawf rhifedd diagnostig cyd-destunol sydd wedi'i ddefnyddio mewn nifer o Ysgolion Fferylliaeth y DU ac wedi cyfrannu at weithgareddau sydd wedi llywio addysg a hyfforddiant myfyrwyr fferylliaeth a meddygol yn uniongyrchol.
Addysgu
- PH1000 Datblygiad Proffesiynol
- PH1122 Rôl y Fferyllydd mewn Ymarfer Proffesiynol
- PH1124 Systemau’r Corff Dynol
- PH2000 Datblygiad Proffesiynol
- PH2107 Gwyddoniaeth Fformiwleiddio
- PH3000 Datblygiad Proffesiynol
- PH3110 Optimeiddio Gofal Fferyllol
- PH3202 Methodoleg Ymchwil
- PH4000 Datblygiad Proffesiynol
- PH4116 Prosiect ysgoloriaeth neu ymchwil ym maes fferylliaeth
- PH4118 Gwyddorau Fferyllol, Ymarfer Fferyllol a’r Claf
Arweinydd Asesiadau ac Adborth yr Ysgol Fferylliaeth a Gwyddorau Fferyllol
Arweinydd Cyfrifiadau Fferyllol yr Ysgol Fferylliaeth a Gwyddorau Fferyllol
Bywgraffiad
Proffil gyrfa
Graddiais o Brifysgol Cymru, Caerdydd yn 2001 gyda gradd MPharm ac yna symudais i fy mlwyddyn cyn-gofrestru mewn fferylliaeth gymunedol. Yn ystod haf 2002 deuthum yn aelod o'r Gymdeithas Fferyllol Frenhinol Prydain Fawr a dechreuais ymarfer proffesiynol fel fferyllydd locwm, gan weithio'n rhan-amser yn y sector cymunedol.
Roedd hyn yn cyd-daro â dechrau fy astudiaethau PhD ym Mhrifysgol Caerdydd lle treuliais dair blynedd yn ymchwilio i systemau cyflenwi trawsdermaidd newydd ar gyfer cyflwyno a mynegi DNA plasmid allgenaidd mewn croen dynol. Yn 2005, wrth gwblhau fy astudiaethau PhD, dechreuais gontract byr ym Mhrifysgol Caerdydd fel Cymrawd Addysgu ac yn ystod y cyfnod hwn datblygais fy niddordeb addysgeg mewn cyfrifiadau rhifedd a meddygaeth sy'n seiliedig ar fathemateg, sy'n faes dysgu ac addysgu rwy'n parhau i fod yn angerddol amdano.
Yn ystod haf 2006, ar ôl graddio gyda fy PhD, cymerais Ddarlithyddiaeth yn Ysgol Fferylliaeth Caerdydd ac ers hynny rwyf wedi cael fy mhenodi'n Uwch-ddarlithydd (2014), ac yn awr yn Ddarllenydd (2023). Rwy'n parhau i weithio'n angerddol ar systemau cyflenwi cyffuriau sy'n seiliedig ar ficronodwydd ar gyfer darparu brechlynnau, biologics a nanoronynnau i'r croen. Fodd bynnag, yn ystod y degawd diwethaf rwyf hefyd wedi gweithio'n agos gyda'r diwydiant fferyllol i ddatblygu mewnanadlyddion powdr sych (DPIs) sy'n seiliedig ar gapsiwl ar gyfer cyflenwi cyffuriau ysgyfeiniol, ac yn 2015 dechreuais weithio ar adeiladu bio-argraffydd i greu modelau croen dynol ar gyfer y labordy.
Rwy'n ymchwilydd cydweithredol iawn sydd bob amser wedi gwerthfawrogi perthnasoedd rhyngddisgyblaethol â chydweithwyr o sefydliadau academaidd, diwydiant, cyrff rheoleiddio a sefydliadau anllywodraethol. Rwy'n mwynhau rolau fel aelod o bwyllgor Cymdeithas Rhyddhau Rheoledig y Deyrnas Unedig ac Iwerddon (UKICRS®) (ers 2013) a chyd-Gadeirydd y Microneedle Array Patch - Regulatory Working Group (MAP-RWG) (ers 2018).
Aelodaethau proffesiynol
- Gweithgor Patch-Rheoleiddio Array Microneedle (MAP-RWG)
- Cymdeithas Rhyddhau Rheoledig y Deyrnas Unedig ac Iwerddon (UKICRS)
- Aelod o Sefydliad Peirianneg a Thrwsio Meinwe Caerdydd (CITER)
- Llysgennad STEM
- Cyngor Fferyllol Cyffredinol
- Aelod o'r Cyngor Fferyllol Cyffredinol (GPhC) (2002-2018)
Pwyllgorau ac adolygu
- Cyd-gadeirydd Gweithgor Patch-Regulatory Array Microneedle (MAP-RWG) (2019 - presennol)
- Aelod o'r Pwyllgor Llywio ar gyfer y Gynhadledd Ryngwladol ar Micronodwyddau (2016 - presennol); Cyd-gynnal y Gynhadledd Ryngwladol ar Micronodwyddau 2016
- Aelod o'r Pwyllgor dros Gymdeithas Rhyddhau Rheoledig y DU ac Iwerddon (UKICRS) (2013 - presennol
