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Dr William Davies
(e/fe)
MBiochem PhD FHEA
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for William Davies
Darllenydd
Trosolwyg
Themâu ymchwil : Niwrowyddoniaeth, Endocrinoleg a Geneteg
Mae gen i ddiddordeb yn y mecanweithiau (epi)genetig, endocrin ac imiwnolegol sy'n sail i wahaniaethau rhyw mewn swyddogaeth, ymddygiad a ffisioleg. Mae fy ngwaith yn canolbwyntio ar rôl genynnau ar y cromosomau rhyw (h.y. yr X a'r Y), sy'n cael eu hetifeddu'n anghymesur rhwng y rhywiau: mae menywod yn etifeddu dau gromosom X (un gan bob rhiant), tra bod dynion yn etifeddu dim ond un cromosom X (bob amser gan eu mam) a chromosom Y gan eu tad. Prif nodau fy ymchwil yw: a) deall pam mae'r rhywiau yn wahanol agored i gyflyrau niwroddatblygiadol, seiciatrig a meddygol, b) deall y pathoffisioleg sy'n sail i anhwylderau seicolegol sy'n gysylltiedig â beichiogrwydd a genedigaeth, a c) helpu i ddatblygu therapïau mwy effeithiol sy'n benodol i ryw. Mae gennyf ddiddordeb hefyd mewn iechyd meddwl a chorfforol mewn cyflyrau croen (yn enwedig ichthyosis sy'n gysylltiedig ag X), ac rwy'n gweithio gyda sefydliadau'r trydydd sector yn genedlaethol ac yn rhyngwladol (e.e. Grŵp Cymorth Ichthyosis y DU a'r Sefydliad ar gyfer Ichthyosis a Mathau o Groen Cysylltiedig (FIRST))
Fel Swyddog Meinwe Dynol ar gyfer yr Ysgol Seicoleg, ac aelod o Bwyllgor Llywodraethu Ymchwil Meinwe Dynol y Brifysgol, rwy'n gyfrifol am sicrhau bod unrhyw ymchwil sy'n ymwneud â samplau meinwe dynol yn cael ei gynnal yn gyfreithlon. Rwyf hefyd yn gynrychiolydd yr Ysgol Seicoleg ar Banel Lles ac Ymchwil Anifeiliaid y Brifysgol (AWARP). Yn MEDIC, arweiniais y rhaglen INSPIRE, cynllun sy'n cael ei redeg gan yr Academi Gwyddorau Meddygol i annog myfyrwyr meddygol, deintyddiaeth a milfeddygol israddedig i gymryd rhan mewn gweithgareddau ymchwil.
Crynodeb lleoliad
Rwy'n gweithio yn yr Ysgolion Seicoleg (PSYCH) a Meddygaeth (MEDIC) ym Mhrifysgol Caerdydd . Rwy'n aelod o'r Grŵp Geneteg Ymddygiadol (PSYCH/MEDIC), y Ganolfan Geneteg a Genomeg Niwroseiciatrig (MEDIC), yr Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol (MEDIC) a'r Sefydliad Niwrowyddoniaeth ac Arloesi Iechyd Meddwl (PSYCH/MEDIC).
Cyhoeddiad
2026
- Humby, T. et al. 2026. Physiological and behavioural characterisation of a novel steroid sulfatase‐deficient mouse. Genes, Brain and Behavior 25 (4) e70061. (10.1111/gbb.70061)
- Elgie, T. , Davies, W. and Wren, G. H. 2026. A mixed-methods online survey approach using retrospective self-reporting to characterise congenital ichthyoses across age groups. Orphanet Journal of Rare Diseases 21 209. (10.1186/s13023-026-04358-7)
- Davies, W. 2026. Does hypothalamic CCN3 hypersecretion confer postpartum mood disorder risk?. Translational Psychiatry 16 195. (10.1038/s41398-026-03969-9)
2025
- Davies, W. 2025. The importance of cardiac screening in X-linked ichthyosis: a plea [Letter to Editor]. Clinical and Experimental Dermatology 50 (9), pp.1876-1877. (10.1093/ced/llaf221)
- Davies, W. 2025. Informing guidelines for managing X-linked ichthyosis: expert commentary. [Online].Hospital Healthcare Europe. Available at: https://hospitalhealthcare.com/specialisms/dermatology/informing-guidelines-for-managing-x-linked-ichthyosis-expert-commentary/.
- Wren, G. et al. 2025. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Archives of Dermatological Research 317 351. (10.1007/s00403-025-03884-x)
- Alsubeeh, N. A. et al., 2025. CCDC47 gene and trichohepatoneurodevelopmental syndrome: Report of the fifth and sixth cases from Saudi Arabia. The American Journal of Medical Genetics - Part A 197 (1) e63784. (10.1002/ajmg.a.63784)
2024
- Wren, G. H. and Davies, W. 2024. Cardiac arrhythmia in individuals with steroid sulfatase deficiency (X linked ichthyosis): candidate anatomical and biochemical pathways. Essays in Biochemistry 68 (4), pp.423-429. EBC20230098. (10.1042/EBC20230098)
- Wren, G. et al. 2024. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Research Square
- Al-Enezi, E. et al., 2024. Helsmoortel-Van der Aa syndrome in a 13-year-old girl with autistic spectrum disorder, dysmorphism, a right solitary kidney, and polycystic ovaries: a case report.. Journal of Medical Case Reports 18 422. (10.1186/s13256-024-04746-2)
- Wren, G. et al. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior 23 (3) e12893. (10.1111/gbb.12893)
2023
- Steventon, J. J. et al. 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158 106393. (10.1016/j.psyneuen.2023.106393)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60 , pp.636-643. (10.1136/jmg-2022-108862)
2022
- Wren, G. H. and Davies, W. 2022. X-linked ichthyosis: New insights into a multi-system disorder. Skin Health and Disease 2 (4) e179. (10.1002/ski2.179)
- Hamshere, M. L. et al. 2022. Embedding genomic research into teaching practice: the rewards and potential pitfalls. Genetics Society News 87 , pp.30-31.
- Shepherd, F. and Davies, W. 2022. An update on the presentation, nosology, and causes of postpartum psychosis. Psychiatric Times 39 (6), pp.23-25.
- Wren, G. et al. 2022. Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis. Clinical and Experimental Dermatology 47 (6), pp.1097-1108. (10.1111/ced.15116)
- Brcic, L. et al., 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2 (3) 100109. (10.1016/j.xjidi.2022.100109)
- Wren, G. and Davies, W. 2022. Sex-linked genetic mechanisms and atrial fibrillation risk. European Journal of Medical Genetics 65 (4) 104459. (10.1016/j.ejmg.2022.104459)
2021
- Thippeswamy, H. and Davies, W. 2021. A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase-deficient individuals. Archives of Women's Mental Health 24 , pp.391-401. (10.1007/s00737-020-01093-1)
- Davies, W. 2021. The contribution of Xp22.31 gene dosage to Turner and Klinefelter syndromes and sex-biased phenotypes. European Journal of Medical Genetics 64 (4) 104169. (10.1016/j.ejmg.2021.104169)
2020
- Brcic, L. et al. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57 (10), pp.692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S. et al. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29 (17), pp.2872-2881. (10.1093/hmg/ddaa174)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237 , pp.1745-1756. (10.1007/s00213-020-05496-x)
2019
- Davies, W. 2019. An analysis of Cellular Communication Network (CCN) proteins as candidate mediators of postpartum psychosis risk. Frontiers in Psychiatry 10 876. (10.3389/fpsyt.2019.00876)
- O'Brien, H. et al. 2019. Sex differences in gene expression in the human fetal brain. [Online].bioRxiv. (10.1101/483636)Available at: https://doi.org/10.1101/483636.
- Cavenagh, A. , Chatterjee, S. and Davies, W. 2019. Behavioural and psychiatric phenotypes in female carriers of genetic mutations associated with X-linked ichthyosis. PLoS ONE 14 (2) e0212330. (10.1371/journal.pone.0212330)
- Davies, W. and Wilkinson, L. 2019. Editorial overview: special issue on epigenetics and genomic imprinting. Current Opinion in Behavioral Sciences 25 , pp.iii-v. (10.1016/j.cobeha.2018.12.006)
- Humby, T. and Davies, W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Translational Neuroscience 10 (1), pp.168-174. (10.1515/tnsci-2019-0030)
2018
- Dazzan, P. , Fusté, M. and Davies, W. 2018. Do defective immune system-mediated myelination processes increase postpartum psychosis risk?. Trends in Molecular Medicine 24 (11), pp.942-949. (10.1016/j.molmed.2018.09.002)
- Davies, W. 2018. Sulfation pathways: The steroid sulfate axis and its relationship to maternal behaviour and mental health. Journal of Molecular Endocrinology 61 , pp.T199-T210. (10.1530/JME-17-0219)
- Richards, G. et al., 2018. 2D:4D digit ratio and religiosity in university student and general population samples. Transpersonal Psychology Review 20 (1), pp.23-36.
2017
- Malik, A. et al., 2017. X-linked ichthyosis associated with psychosis and behavioral abnormalities: a case report. Journal of Medical Case Reports 11 267. (10.1186/s13256-017-1420-2)
- Richards, G. , Bellin, W. and Davies, W. 2017. Familial digit ratio (2D:4D) associations in a general population sample from Wales. Early Human Development 112 , pp.14-19. (10.1016/j.earlhumdev.2017.06.006)
- Green, T. , Naylor, P. and Davies, W. 2017. Attention Deficit Hyperactivity Disorder (ADHD) in phenotypically-similar neurogenetic conditions: Turner syndrome and the RASopathies. Journal of Neurodevelopmental Disorders 9 (25), pp.794-802. (10.1186/s11689-017-9205-x)
- Davies, W. 2017. Understanding the pathophysiology of postpartum psychosis: challenges and new approaches. World Journal of Psychiatry 7 (2), pp.77-88. http://dx.doi.org/10.5498/wjp.v7.i2.77. (10.5498/wjp.v7.i2.77)
- Humby, T. et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior 7 (3) e00646. (10.1002/brb3.646)
2016
- Humby, T. et al. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74 , pp.363-370. (10.1016/j.psyneuen.2016.09.019)
- Davies, W. 2016. Insights into rare diseases from social media surveys. Orphanet Journal of Rare Diseases 11 151. (10.1186/s13023-016-0532-x)
- Chatterjee, S. , Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. PLoS ONE 11 (10), pp.e0164417. e0164417. (10.1371/journal.pone.0164417)
2015
- Hinton, R. et al., 2015. Preliminary evidence for aortopathy and an x-linked parent-of-origin effect on aortic valve malformation in a mouse model of Turner syndrome. Journal of Cardiovascular Development and Disease 2 (3), pp.190-199. (10.3390/jcdd2030190)
- Davies, W. and Duncan, L. 2015. Editorial overview: Behavioral genetics. Current Opinion in Behavioral Sciences 2 , pp.v-vii. (10.1016/j.cobeha.2014.12.002)
2014
- Davies, W. et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39 , pp.2622-2632. (10.1038/npp.2014.115)
- Davies, W. 2014. Sex differences in Attention Deficit Hyperactivity Disorder: Candidate genetic and endocrine mechanisms. Frontiers in Neuroendocrinology 35 (3), pp.331-346. (10.1016/j.yfrne.2014.03.003)
- Trent, S. et al. 2014. Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder. Molecular Autism 5 (1) 21. (10.1186/2040-2392-5-21)
2013
- Kopsida, E. et al., 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8 (8) e73699. (10.1371/journal.pone.0073699)
- Trent, S. and Davies, W. 2013. Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency. World Journal of Translational Medicine 2 (1), pp.1-12. (10.5528/wjtm.v2.i1.1)
- Davies, W. 2013. Using mouse models to investigate sex-linked genetic effects on brain, behaviour and vulnerability to neuropsychiatric disorders. Brain Research Bulletin 92 , pp.12-20. (10.1016/j.brainresbull.2011.06.018)
- Trent, S. et al. 2013. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology 38 (8), pp.1370-1380. (10.1016/j.psyneuen.2012.12.002)
- van den Bos, R. et al., 2013. Cross-species approaches to pathological gambling: A review targeting sex differences, adolescent vulnerability and ecological validity of research tools. Neuroscience & Biobehavioral Reviews 37 (10.2), pp.2454-2471. (10.1016/j.neubiorev.2013.07.005)
2012
- Trent, S. et al. 2012. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology 37 (2), pp.221-229. (10.1016/j.psyneuen.2011.06.006)
- Davies, W. 2012. Does steroid sulfatase deficiency influence postpartum psychosis risk?. Trends in Molecular Medicine 18 (5), pp.256-262. (10.1016/j.molmed.2012.03.001)
- Trent, S. et al. 2012. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology 37 (5), pp.1267-1274. (10.1038/npp.2011.314)
2011
- Stergiakouli, E. et al., 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10 (3), pp.334-344. (10.1111/j.1601-183x.2010.00672.x)
- Davies, W. 2011. Functional themes from psychiatric genome-wide screens. Frontiers in Genetics 2 89. (10.3389/fgene.2011.00089)
- Kopsida, E. , Mikaelsson, M. A. and Davies, W. 2011. The role of imprinted genes in mediating susceptibility to neuropsychiatric disorders. Hormones and Behavior 59 (3), pp.375-382. (10.1016/j.yhbeh.2010.04.005)
- Lynn, P. M. , Stergiakouli, E. and Davies, W. 2011. The genomics of Turner syndrome and sex-biased neuropsychiatric disorders. In: Clelland, J. D. ed. Genomics, proteomics, and the nervous system. Advances in neurobiology Vol. 2.Springer. , pp.3-20.
- Trent, S. and Davies, W. 2011. The influence of sex-linked genetic mechanisms on attention and impulsivity. Biological Psychology 89 (1), pp.1-13. (10.1016/j.biopsycho.2011.09.011)
2010
- Davies, W. 2010. Genomic imprinting on the X chromosome: implications for brain and behavioral phenotypes. Annals of the New York Academy of Sciences 1204 (s1), pp.14-19. (10.1111/j.1749-6632.2010.05567.x)
2009
- Davies, W. et al. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66 (4), pp.360-367. (10.1016/j.biopsych.2009.01.001)
- Kopsida, E. et al. 2009. The role of the Y chromosome in brain function. The Open Neuroendocrinology Journal 2 (1), pp.20-30. (10.2174/1876528900902010020)
2008
- Davies, W. and Isles, A. R. 2008. Genomic imprinting and disorders of the social brain; shades of grey rather than black and white. Behavioral and Brain Sciences 31 (3), pp.265-266. (10.1017/S0140525X08004263)
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
- Davies, W. et al. 2008. Imprinted genes and neuroendocrine function. Frontiers in Neuroendocrinology 29 (3), pp.413-427. (10.1016/j.yfrne.2007.12.001)
2007
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Lynn, P. M. and Davies, W. 2007. The 39,XO mouse as a model for the neurobiology of Turner syndrome and sex-biased neuropsychiatric disorders. Behavioural Brain Research 179 (2), pp.173-182. (10.1016/j.bbr.2007.02.013)
- Wilkinson, L. S. , Davies, W. and Isles, A. R. 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11), pp.832-843. (10.1038/nrn2235)
2006
- Davies, W. et al. 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1), pp.35-44. (10.1002/bies.20341)
- Davies, W. and Wilkinson, L. S. 2006. It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Research 1126 (1), pp.36-45. (10.1016/j.brainres.2006.09.105)
- Isles, A. R. , Davies, W. and Wilkinson, L. S. 2006. Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1476), pp.2229-2237. (10.1098/rstb.2006.1942)
2005
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2005. Imprinted gene expression in the brain. Neuroscience & Biobehavioral Reviews 29 (3), pp.421-430. (10.1016/j.neubiorev.2004.11.007)
2004
- Isles, A. R. et al. 2004. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Human Molecular Genetics 13 (17), pp.1849-1855. (10.1093/hmg/ddh203)
- Davies, W. et al. 2004. Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain. Gene Expression Patterns 4 (6), pp.741-747. (10.1016/j.modgep.2004.03.008)
2001
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2001. Imprinted genes and mental dysfunction. Annals of Medicine 33 (6), pp.428-436. (10.3109/07853890108995956)
1999
- Humby, T. et al. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11 (8), pp.2813-2823. (10.1046/j.1460-9568.1999.00701.x)
Adrannau llyfrau
- Lynn, P. M. , Stergiakouli, E. and Davies, W. 2011. The genomics of Turner syndrome and sex-biased neuropsychiatric disorders. In: Clelland, J. D. ed. Genomics, proteomics, and the nervous system. Advances in neurobiology Vol. 2.Springer. , pp.3-20.
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
Erthyglau
- Humby, T. et al. 2026. Physiological and behavioural characterisation of a novel steroid sulfatase‐deficient mouse. Genes, Brain and Behavior 25 (4) e70061. (10.1111/gbb.70061)
- Elgie, T. , Davies, W. and Wren, G. H. 2026. A mixed-methods online survey approach using retrospective self-reporting to characterise congenital ichthyoses across age groups. Orphanet Journal of Rare Diseases 21 209. (10.1186/s13023-026-04358-7)
- Davies, W. 2026. Does hypothalamic CCN3 hypersecretion confer postpartum mood disorder risk?. Translational Psychiatry 16 195. (10.1038/s41398-026-03969-9)
- Davies, W. 2025. The importance of cardiac screening in X-linked ichthyosis: a plea [Letter to Editor]. Clinical and Experimental Dermatology 50 (9), pp.1876-1877. (10.1093/ced/llaf221)
- Wren, G. et al. 2025. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Archives of Dermatological Research 317 351. (10.1007/s00403-025-03884-x)
- Alsubeeh, N. A. et al., 2025. CCDC47 gene and trichohepatoneurodevelopmental syndrome: Report of the fifth and sixth cases from Saudi Arabia. The American Journal of Medical Genetics - Part A 197 (1) e63784. (10.1002/ajmg.a.63784)
- Wren, G. H. and Davies, W. 2024. Cardiac arrhythmia in individuals with steroid sulfatase deficiency (X linked ichthyosis): candidate anatomical and biochemical pathways. Essays in Biochemistry 68 (4), pp.423-429. EBC20230098. (10.1042/EBC20230098)
- Wren, G. et al. 2024. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Research Square
- Al-Enezi, E. et al., 2024. Helsmoortel-Van der Aa syndrome in a 13-year-old girl with autistic spectrum disorder, dysmorphism, a right solitary kidney, and polycystic ovaries: a case report.. Journal of Medical Case Reports 18 422. (10.1186/s13256-024-04746-2)
- Wren, G. et al. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior 23 (3) e12893. (10.1111/gbb.12893)
- Steventon, J. J. et al. 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158 106393. (10.1016/j.psyneuen.2023.106393)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60 , pp.636-643. (10.1136/jmg-2022-108862)
- Wren, G. H. and Davies, W. 2022. X-linked ichthyosis: New insights into a multi-system disorder. Skin Health and Disease 2 (4) e179. (10.1002/ski2.179)
- Hamshere, M. L. et al. 2022. Embedding genomic research into teaching practice: the rewards and potential pitfalls. Genetics Society News 87 , pp.30-31.
- Shepherd, F. and Davies, W. 2022. An update on the presentation, nosology, and causes of postpartum psychosis. Psychiatric Times 39 (6), pp.23-25.
- Wren, G. et al. 2022. Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis. Clinical and Experimental Dermatology 47 (6), pp.1097-1108. (10.1111/ced.15116)
- Brcic, L. et al., 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2 (3) 100109. (10.1016/j.xjidi.2022.100109)
- Wren, G. and Davies, W. 2022. Sex-linked genetic mechanisms and atrial fibrillation risk. European Journal of Medical Genetics 65 (4) 104459. (10.1016/j.ejmg.2022.104459)
- Thippeswamy, H. and Davies, W. 2021. A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase-deficient individuals. Archives of Women's Mental Health 24 , pp.391-401. (10.1007/s00737-020-01093-1)
- Davies, W. 2021. The contribution of Xp22.31 gene dosage to Turner and Klinefelter syndromes and sex-biased phenotypes. European Journal of Medical Genetics 64 (4) 104169. (10.1016/j.ejmg.2021.104169)
- Brcic, L. et al. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57 (10), pp.692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S. et al. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29 (17), pp.2872-2881. (10.1093/hmg/ddaa174)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237 , pp.1745-1756. (10.1007/s00213-020-05496-x)
- Davies, W. 2019. An analysis of Cellular Communication Network (CCN) proteins as candidate mediators of postpartum psychosis risk. Frontiers in Psychiatry 10 876. (10.3389/fpsyt.2019.00876)
- Cavenagh, A. , Chatterjee, S. and Davies, W. 2019. Behavioural and psychiatric phenotypes in female carriers of genetic mutations associated with X-linked ichthyosis. PLoS ONE 14 (2) e0212330. (10.1371/journal.pone.0212330)
- Davies, W. and Wilkinson, L. 2019. Editorial overview: special issue on epigenetics and genomic imprinting. Current Opinion in Behavioral Sciences 25 , pp.iii-v. (10.1016/j.cobeha.2018.12.006)
- Humby, T. and Davies, W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Translational Neuroscience 10 (1), pp.168-174. (10.1515/tnsci-2019-0030)
- Dazzan, P. , Fusté, M. and Davies, W. 2018. Do defective immune system-mediated myelination processes increase postpartum psychosis risk?. Trends in Molecular Medicine 24 (11), pp.942-949. (10.1016/j.molmed.2018.09.002)
- Davies, W. 2018. Sulfation pathways: The steroid sulfate axis and its relationship to maternal behaviour and mental health. Journal of Molecular Endocrinology 61 , pp.T199-T210. (10.1530/JME-17-0219)
- Richards, G. et al., 2018. 2D:4D digit ratio and religiosity in university student and general population samples. Transpersonal Psychology Review 20 (1), pp.23-36.
- Malik, A. et al., 2017. X-linked ichthyosis associated with psychosis and behavioral abnormalities: a case report. Journal of Medical Case Reports 11 267. (10.1186/s13256-017-1420-2)
- Richards, G. , Bellin, W. and Davies, W. 2017. Familial digit ratio (2D:4D) associations in a general population sample from Wales. Early Human Development 112 , pp.14-19. (10.1016/j.earlhumdev.2017.06.006)
- Green, T. , Naylor, P. and Davies, W. 2017. Attention Deficit Hyperactivity Disorder (ADHD) in phenotypically-similar neurogenetic conditions: Turner syndrome and the RASopathies. Journal of Neurodevelopmental Disorders 9 (25), pp.794-802. (10.1186/s11689-017-9205-x)
- Davies, W. 2017. Understanding the pathophysiology of postpartum psychosis: challenges and new approaches. World Journal of Psychiatry 7 (2), pp.77-88. http://dx.doi.org/10.5498/wjp.v7.i2.77. (10.5498/wjp.v7.i2.77)
- Humby, T. et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior 7 (3) e00646. (10.1002/brb3.646)
- Humby, T. et al. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74 , pp.363-370. (10.1016/j.psyneuen.2016.09.019)
- Davies, W. 2016. Insights into rare diseases from social media surveys. Orphanet Journal of Rare Diseases 11 151. (10.1186/s13023-016-0532-x)
- Chatterjee, S. , Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. PLoS ONE 11 (10), pp.e0164417. e0164417. (10.1371/journal.pone.0164417)
- Hinton, R. et al., 2015. Preliminary evidence for aortopathy and an x-linked parent-of-origin effect on aortic valve malformation in a mouse model of Turner syndrome. Journal of Cardiovascular Development and Disease 2 (3), pp.190-199. (10.3390/jcdd2030190)
- Davies, W. and Duncan, L. 2015. Editorial overview: Behavioral genetics. Current Opinion in Behavioral Sciences 2 , pp.v-vii. (10.1016/j.cobeha.2014.12.002)
- Davies, W. et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39 , pp.2622-2632. (10.1038/npp.2014.115)
- Davies, W. 2014. Sex differences in Attention Deficit Hyperactivity Disorder: Candidate genetic and endocrine mechanisms. Frontiers in Neuroendocrinology 35 (3), pp.331-346. (10.1016/j.yfrne.2014.03.003)
- Trent, S. et al. 2014. Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder. Molecular Autism 5 (1) 21. (10.1186/2040-2392-5-21)
- Kopsida, E. et al., 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8 (8) e73699. (10.1371/journal.pone.0073699)
- Trent, S. and Davies, W. 2013. Cognitive, behavioural and psychiatric phenotypes associated with steroid sulfatase deficiency. World Journal of Translational Medicine 2 (1), pp.1-12. (10.5528/wjtm.v2.i1.1)
- Davies, W. 2013. Using mouse models to investigate sex-linked genetic effects on brain, behaviour and vulnerability to neuropsychiatric disorders. Brain Research Bulletin 92 , pp.12-20. (10.1016/j.brainresbull.2011.06.018)
- Trent, S. et al. 2013. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology 38 (8), pp.1370-1380. (10.1016/j.psyneuen.2012.12.002)
- van den Bos, R. et al., 2013. Cross-species approaches to pathological gambling: A review targeting sex differences, adolescent vulnerability and ecological validity of research tools. Neuroscience & Biobehavioral Reviews 37 (10.2), pp.2454-2471. (10.1016/j.neubiorev.2013.07.005)
- Trent, S. et al. 2012. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology 37 (2), pp.221-229. (10.1016/j.psyneuen.2011.06.006)
- Davies, W. 2012. Does steroid sulfatase deficiency influence postpartum psychosis risk?. Trends in Molecular Medicine 18 (5), pp.256-262. (10.1016/j.molmed.2012.03.001)
- Trent, S. et al. 2012. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology 37 (5), pp.1267-1274. (10.1038/npp.2011.314)
- Stergiakouli, E. et al., 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10 (3), pp.334-344. (10.1111/j.1601-183x.2010.00672.x)
- Davies, W. 2011. Functional themes from psychiatric genome-wide screens. Frontiers in Genetics 2 89. (10.3389/fgene.2011.00089)
- Kopsida, E. , Mikaelsson, M. A. and Davies, W. 2011. The role of imprinted genes in mediating susceptibility to neuropsychiatric disorders. Hormones and Behavior 59 (3), pp.375-382. (10.1016/j.yhbeh.2010.04.005)
- Trent, S. and Davies, W. 2011. The influence of sex-linked genetic mechanisms on attention and impulsivity. Biological Psychology 89 (1), pp.1-13. (10.1016/j.biopsycho.2011.09.011)
- Davies, W. 2010. Genomic imprinting on the X chromosome: implications for brain and behavioral phenotypes. Annals of the New York Academy of Sciences 1204 (s1), pp.14-19. (10.1111/j.1749-6632.2010.05567.x)
- Davies, W. et al. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66 (4), pp.360-367. (10.1016/j.biopsych.2009.01.001)
- Kopsida, E. et al. 2009. The role of the Y chromosome in brain function. The Open Neuroendocrinology Journal 2 (1), pp.20-30. (10.2174/1876528900902010020)
- Davies, W. and Isles, A. R. 2008. Genomic imprinting and disorders of the social brain; shades of grey rather than black and white. Behavioral and Brain Sciences 31 (3), pp.265-266. (10.1017/S0140525X08004263)
- Davies, W. et al. 2008. Imprinted genes and neuroendocrine function. Frontiers in Neuroendocrinology 29 (3), pp.413-427. (10.1016/j.yfrne.2007.12.001)
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Lynn, P. M. and Davies, W. 2007. The 39,XO mouse as a model for the neurobiology of Turner syndrome and sex-biased neuropsychiatric disorders. Behavioural Brain Research 179 (2), pp.173-182. (10.1016/j.bbr.2007.02.013)
- Wilkinson, L. S. , Davies, W. and Isles, A. R. 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11), pp.832-843. (10.1038/nrn2235)
- Davies, W. et al. 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1), pp.35-44. (10.1002/bies.20341)
- Davies, W. and Wilkinson, L. S. 2006. It is not all hormones: Alternative explanations for sexual differentiation of the brain. Brain Research 1126 (1), pp.36-45. (10.1016/j.brainres.2006.09.105)
- Isles, A. R. , Davies, W. and Wilkinson, L. S. 2006. Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1476), pp.2229-2237. (10.1098/rstb.2006.1942)
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2005. Imprinted gene expression in the brain. Neuroscience & Biobehavioral Reviews 29 (3), pp.421-430. (10.1016/j.neubiorev.2004.11.007)
- Isles, A. R. et al. 2004. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Human Molecular Genetics 13 (17), pp.1849-1855. (10.1093/hmg/ddh203)
- Davies, W. et al. 2004. Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain. Gene Expression Patterns 4 (6), pp.741-747. (10.1016/j.modgep.2004.03.008)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2001. Imprinted genes and mental dysfunction. Annals of Medicine 33 (6), pp.428-436. (10.3109/07853890108995956)
- Humby, T. et al. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11 (8), pp.2813-2823. (10.1046/j.1460-9568.1999.00701.x)
Gwefannau
- Davies, W. 2025. Informing guidelines for managing X-linked ichthyosis: expert commentary. [Online].Hospital Healthcare Europe. Available at: https://hospitalhealthcare.com/specialisms/dermatology/informing-guidelines-for-managing-x-linked-ichthyosis-expert-commentary/.
- O'Brien, H. et al. 2019. Sex differences in gene expression in the human fetal brain. [Online].bioRxiv. (10.1101/483636)Available at: https://doi.org/10.1101/483636.
Ymchwil
Pynciau ymchwil a phapurau cysylltiedig
Mae ein gwaith yn defnyddio amrywiaeth eang o dechnegau arbrofol gan gynnwys: profion gweithredol a digymell o ymddygiad mewn cnofilod, dadansoddiad anatomegol a biocemegol o feinweoedd corff, profion mynegiant genynnau a phrotein, mesur marcwyr endocrin, addasu/dadansoddi genetig a geneteg foleciwlaidd dynol, profion niwroseicolegol, a dulliau arolygu ar-lein.
1. Rôl sylffatase steroid mewn ffenoteipiau ymennydd, ymddygiadol a ffisiolegol mewn dyn a llygoden
Mae ein gwaith blaenorol mewn llygod a bodau dynol wedi awgrymu y gall y genyn STS, sy'n amgodio'r ensym steroid sulfatase sy'n modiwleiddio niwrosteroidau, ddylanwadu ar ystod eang o swyddogaethau ymddygiadol, gwybyddol a ffisiolegol, yn enwedig sylw a rhythm y galon. Nod gwaith parhaus mewn modelau cnofilod a phoblogaethau clinigol yw pennu prosesau biolegol sy'n sensitif i effeithiau swyddogaeth sylffatase steroid, ac egluro'r mecanweithiau niwrobiolegol y gall swyddogaeth sylffatase steroid effeithio ar wybyddiaeth. Mae'r gwaith hwn yn berthnasol yn uniongyrchol i'r anhwylder prin ichthyosis sy'n gysylltiedig â X (a achosir gan ddiffyg sylffatase steroid), a gall hefyd daflu goleuni ar y mecanweithiau sy'n sail i anhwylderau datblygiadol a chardiaidd idiopathig (e.e. ffibriliad atrïaidd) ac anhwylderau hwyliau ôl-enedigol.
Mae llygod sy'n ddiffygiol o STS yn dangos mwy o debygolrwydd o arrhythmias cardiaidd: Garland-Thomas et al. (2026) bioRxiv doi:10.64898/2026.07.22.739997
Canfyddiadau cyntaf o fodel llygoden newydd sy'n ddiffygiol o STS: Humby et al. (2026) Genes Brain and Behavior doi:10.1111/gbb.70061
Galwad i annog dermatolegwyr i sgrinio am broblemau'r galon mewn unigolion ag ichthyosis sy'n gysylltiedig ag X, ac i gyfeirio at gardiolegwyr os oes angen Davies (2025) Clinical and Experimental Dermatology doi:10.1093/ced/llaf221
Asesu dichonoldeb mesur rhythmau'r galon mewn dynion ag ichthyosis sy'n gysylltiedig â X Wren et al (2025) Archifau Ymchwil Dermatolegol 317 (1): 351 doi: 10.1007 / s00403-025-03884-x
Sail anatomegol a biocemegol bosibl i fwy o risg arrhythmia mewn ichthyosis sy'n gysylltiedig ag X Wren and Davies (2024) Essays in Biochemistry 68:EBC20230098 doi:10.1042/EBC20230098
Nodweddu problemau rhythm y galon mewn unigolion â ichthyosis sy'n gysylltiedig â X/dileu Xp22.31; STS wedi'i nodi fel genyn ymgeisydd Wren et al. (2022) Journal of Medical Genetics doi:10.1136/jmg-2022-108862
Croen a chyflyrau allgroenol mewn ichthyosis sy'n gysylltiedig ag X a mecanwaith biolegol uno posibl: Wren and Davies (2022) Skin Health and Disease doi:10.1002/ski2.179
Materion meddygol comorbid mewn ichthyosis sy'n gysylltiedig ag X: Brcic et al. (2022) JID Innovations doi:10.1016/j.xjidi.2022.100109
Ffenoteipiau meddygol a niwroymddygiadol mewn cludwyr gwrywaidd a benywaidd o ddyblygiadau Xp22.31 yn Biofanc y DU: Gubb et al. (2020) Geneteg Moleciwlaidd Dynol 29 (17): 2872-2881
Ffenoteipiau meddygol a niwroymddygiadol mewn cludwyr dileu genetig sy'n gysylltiedig ag ichthyosis sy'n gysylltiedig â X yn Biobanc y DU: Brcic et al. (2020) Journal of Medical Genetics 57: 692-698; crynodebau lleyg o'r papur hwn ar gael yma ac yma
Ymddygiad ac iechyd meddwl mewn cludwyr benywaidd o fwtaniadau genetig sy'n gysylltiedig ag ichthyosis sy'n gysylltiedig â X: Cavenagh et al. (2019) PLoS ONE 14 (2): e0212330
STS, ymddygiad mamau ac iechyd meddwl: Davies (2018) Journal of Molecular Endocrinology 61(2):T199-T210
Diffyg STS a seicosis: Malik et al. (2017) Journal of Medical Case Reports 11 (1): 267
Amrywiad genetig mewn STS a gwybyddiaeth mewn dynion iach: Humby et al. (2017) Ymennydd ac Ymddygiad 7 (3): e00646
Ymddygiad ac iechyd meddwl mewn dynion ag ichthyosis sy'n gysylltiedig ag X: Chatterjee et al. (2016) PloS ONE 11(10):e0164417
Diffyg STS ac ataliad ymateb mewn llygod: Davies et al. (2014) Niwroseicopharmacology (2014) 39 (11): 2622-32
Diffyg STS a mynegiant genynnau yr ymennydd a niwrocemeg mewn llygod: Trent et al. (2014) Awtistiaeth Moleciwlaidd 5 (1): 21
Diffyg STS a swyddogaeth hippocampal mewn llygod: Trent et al (2013) Psychoneuroendocrinology 38 (8): 1370-80
Diffyg STS a niwrocemeg mewn llygod: Trent et al (2012) Niwroseicopharmacology 37 (5): 1267-74
Diffyg ac ymddygiad STS mewn llygod: Trent et al (2012) Psychoneuroendocrinology 37 (2): 221-9
Amrywiad genetig mewn STS a symptomau a gwybyddiaeth mewn bechgyn ag ADHD: Stergiakouli et al (2011) Genynnau Ymennydd ac Ymddygiad 10 (3): 334-44
Diffyg a sylw STS mewn llygod: Davies et al (2009) Seiciatreg Biolegol 66 (4): 360-7
2. Mecanweithiau genetig ac endocrin sy'n sail i wahaniaethau rhyw yn natblygiad, ymddygiad a ffisioleg yr ymennydd
Mae menywod yn etifeddu dau gromosom X (un gan bob rhiant) tra bod gwrywod yn etifeddu un cromosom X (bob amser gan eu mam) a chromosom Y gan eu tad. Mae'r anghymesuredd hwn o etifeddiaeth ar draws y rhywiau yn arwain at dri phrif fecanwaith genetig a allai naill ai sail i wahaniaethau gwrywaidd-benywaidd mewn ffisioleg yn uniongyrchol, neu drwy effeithiau ar hormonau gan gynnwys androgenau ac estrogenau: i) mynegiant genynnau Y-gysylltiedig mewn dynion yn unig (gan gynnwys y genyn sy'n pennu ceilliau SRY), ii) mynegiant uwch o enynnau X-gysylltiedig sy'n dianc rhag anactifadu X mewn meinweoedd benywaidd, a iii) mynegiant gwahaniaethol genynnau X-gysylltiedig sy'n destun y broses epigenetig o argraffu genomig. Mae ein gwaith cydweithredol, mewn modelau cnofilod (e.e. model llygoden 39, XO a Four Core Genotypes ), mewn poblogaethau clinigol, ac mewn cyfranogwyr a meinweoedd iach yn anelu at ymchwilio i ba raddau a phenodoldeb y mae pob un o'r tri mecanwaith hyn yn cyfrannu at wahaniaethau rhyw mewn ffisioleg. Mae'r gwaith hwn yn debygol o lywio ein dealltwriaeth o'r pathoffisioleg foleciwlaidd sy'n sail i aneuploidies cromosom rhyw fel syndromau Turner a Klinefelter, ac anhwylderau niwroddatblygiadol rhagfarnllyd rhyw fel ADHD ac awtistiaeth.
Cysylltiad rhwng hyd oes atgenhedlu, oedran yn y menopos, cyfaint strwythurau lobe amserol yr ymennydd a chof Steventon et al. (2023) Psychoneuroendocrinology doi:10.1016/j.psyneuen.2023.106393
Mecanweithiau genetig sy'n gysylltiedig â rhyw a risg ffibriliad atrïaidd: Wren and Davies (2022) European Journal of Medical Genetics 65(4):104459 doi:10.1016/j.ejmg.2022.104459
Xp22.31 dos genynnau, syndromau Turner a Klinefelter a gwahaniaethau rhyw: Davies (2021) European Journal of Medical Genetics doi:10.1016/j.ejmg.2021.104169
Gwahaniaethau rhyw mewn mynegiant genynnau yn yr ymennydd ffetws dynol: O'Brien et al. (2019) bioRxiv https://doi.org/10.1101/483636
Amlygiad androgen bywyd cynnar a chrefyddoldeb: Richards et al. (2018) Adolygiad Seicoleg Trawsbersonol 20 (1): 23-36
Patrymau teuluol marciwr somatig o amlygiad androgen bywyd cynnar: Richards et al. (2017) Datblygiad Dynol Cynnar 112: 14-19
Adolygiad o'r gorgyffwrdd rhwng RASopathies a syndrom Turner: Green et al. (2017) Journal of Neurodevelopmental Disorders 9:25
Effeithiau cromosom X ar morffoleg y galon mewn llygod: Hinton.et al. (2015) Cyfnodolyn Datblygiad a Chlefyd Cardiofasgwlaidd 2 (3): 190-199
Mecanweithiau genetig ac endocrinaidd sy'n dylanwadu ar risg ADHD: Davies (2014) Frontiers in Neuroendocrinology 35(3):331-46
Cyflenwad cromosom rhyw ac effeithiau endocrin ar ymddygiad mewn llygod: Kopsida et al (2013) PLOS ONE 8 (8): e73699
Ymchwilio i effeithiau genetig sy'n gysylltiedig â rhyw ar ymddygiad mewn llygod: Davies (2013) Bwletin Ymchwil yr Ymennydd 92: 12-20
Adolygiad o effeithiau sy'n gysylltiedig â rhyw ar sylw ac ysgogiad: Trent & Davies (2012) Seicoleg Biolegol 89(1):1-13
Y cromosom Y a swyddogaeth yr ymennydd: Kopsida et al (2009) Y Cyfnodolyn Niwroendocrinoleg Agored 2: 20-30
Ffenoteipiau ymennydd ac ymddygiadol yn y llygoden 39,XO: Lynn et al (2007) Ymchwil Ymddygiadol yr Ymennydd 172 (2): 173-182
Effeithiau X-monosomi ar sylw mewn llygod: Davies et al (2007) Seiciatreg Biolegol 61 (12): 1351-1360
Effeithiau ymennydd ac ymddygiad genynnau argraffedig X-gysylltiedig: Davies et al (2006) BioEssays 28 (1): 35-44
Adolygiad o effeithiau genetig sy'n gysylltiedig â rhyw sy'n annibynnol ar hormonau gonadaidd ar yr ymennydd ac ymddygiad: Davies & Wilkinson (2006) Ymchwil i'r Ymennydd 1126(1):36-45
Effaith wybyddol rhiant tarddiad cysylltiedig â X mewn llygod a genyn argraffedig X-gysylltiedig ymgeisydd newydd: Davies et al (2005) Nature Genetics 37 (6): 625-629
Effeithiau X-monosomi ar ymddygiad sy'n gysylltiedig â phryder mewn llygod: Ynysoedd et al (2004) Geneteg Moleciwlaidd Dynol 13 (17): 1849-1855
3. Deall sail fiolegol risg anhwylder hwyliau ôl-enedigol
Gall mamau newydd gael eu heffeithio gan nifer o gyflyrau seiciatrig sy'n amrywio o ran difrifoldeb a chyffredinrwydd. Mae gennym ddiddordeb arbennig mewn seicosis ôl-enedigol (PP), anhwylder seiciatrig prin ond hynod ddifrifol sy'n effeithio ar famau yn fuan ar ôl genedigaeth ac sy'n cael ei nodweddu gan delusions, swings hwyliau, gorbryder ac anhrefn gwybyddol. Er gwaethaf ei ddifrifoldeb, mae'r niwrobioleg sy'n sail i'r risg PP yn cael ei ddeall yn wael iawn, yn rhannol o ganlyniad i beidio â chael modelau anifeiliaid addas ar gael. Nod ein gwaith mewn modelau cnofilod a phoblogaethau clinigol yw nodi a nodweddu llwybrau risg biolegol credadwy ar gyfer PP, yn y pen draw gyda'r bwriad o ddatblygu triniaethau gwell a biofarcwyr rhagfynegol.
Rhagdybiaeth newydd sy'n awgrymu y gallai echel ymennydd-esgyrn aflonyddu aflonyddu fod yn sail i risg anhwylder hwyliau ôl-enedigol Davies (2026) Seiciatreg Drosiadol doi:10.1038/s41398-026-03969-9
Diweddariad ar seicosis ôl-enedigol Shepherd & Davies (2022) Psychiatric Times 39(6):23-25
Llwybr risg moleciwlaidd newydd ar gyfer anhwylderau hwyliau ôl-enedigol: cliwiau gan unigolion sy'n ddiffygiol o sylffatase steroid Thippeswamy & Davies (2020) Archifau Iechyd Meddwl Menywod doi:10.1007/s00737-020-01093-1
Proteinau CCN fel cyfryngwyr ymgeisiol risg o anhwylder hwyliau ôl-enedigol (mae'r papur hwn ymhlith y 3% uchaf o bapurau mwyaf poblogaidd ar draws holl gyfnodolion Frontiers) Davies (2019) Frontiers in Psychiatry 10:876
Mynegiant genynnau yr ymennydd mewn model llygoden newydd o anhwylder hwyliau ôl-enedigol: Humby & Davies (2019) Niwrowyddoniaeth ranslational 10: 168-174
Rhagdybiaeth newydd ar gyfer risg seicosis ôl-enedigol: Dazzan et al. (2018) Tueddiadau mewn Meddygaeth Moleciwlaidd 24 (11): 26-34
STS, ymddygiad mamau ac iechyd meddwl: Davies (2018) Journal of Molecular Endocrinology 61(2):T199-T210
Ymchwilio i pathoffisioleg seicosis ôl-enedigol: Davies (2017) World Journal of Psychiatry 7(2):77-88
Model llygoden newydd o seicosis ôl-enedigol: Humby et al. (2016) Psychoneuroendocrinology 74: 363-370
Diffyg STS a seicosis ôl-enedigol: Davies (2012) Tueddiadau mewn Meddygaeth Moleciwlaidd 18 (5): 256-62
4. Iechyd meddwl a chorfforol mewn cyflyrau croen cynhenid
Yn dilyn ein gwaith mewn ichthyosis sy'n gysylltiedig ag X, rydym wedi dechrau ymchwilio i ffenoteipiau iechyd meddwl ac ymddygiadol mewn cyflyrau croen eraill sydd â rhagdueddiad genetig sylfaenol gan gynnwys ichthyosis vulgaris, psoriasis a chlefyd Darier.
Arolwg ar-lein dulliau cymysg sy'n defnyddio hunan-adrodd ôl-weithredol i nodweddu ichthyoses cynhenid ar draws grwpiau oedran Elgie et al. (2026) Orphanet Journal of Rare Diseases doi:10.1186/s13023-026-04358-7
Cof, hwyliau a niwroanatomeg gysylltiedig mewn unigolion ag ichthyosis sy'n gysylltiedig â X ac ichthyosis vulgaris Wren et al. (2024) Genynnau, Ymennydd ac Ymddygiad 23 (3): e12893 doi: 10.1111 / gbb.12893
Problemau hwyliau a'u hachosion mewn ichthyosis sy'n gysylltiedig â X, ichthyosis vulgaris a psoriasis Wren et al. (2022) Dermatoleg Glinigol ac Arbrofol doi:10.1111/ced.15116
5. Datblygu tasgau gwybyddiaeth cnofilod: deall gwahaniaethau rhyw mewn ymddygiad gamblo
Rydym wedi datblygu nifer o dasgau gweithredol newydd i asesu gwybyddiaeth mewn cnofilod, llawer ohonynt yn analogau o dasgau niwroseicolegol a ddefnyddir i asesu gwybyddiaeth mewn bodau dynol, ac mae sawl un ohonynt bellach wedi'u haddasu i'w defnyddio gyda chyfarpar sgrin gyffwrdd i ganiatáu cyflwyniad ysgogiad soffistigedig. Ar hyn o bryd mae gennym ddiddordeb mewn defnyddio'r tasgau hyn i ddeall sail fiolegol rhagdueddiad gamblo, ac yn benodol, i ddeall pam mae cyffredinrwydd ymddygiad gamblo, a'r dilyniant i gamblo patholegol, yn wahanol rhwng dynion a menywod.
Assay ymddygiadol llygoden newydd o ymddygiad gamblo ac effeithiau cyffuriau serotonergig a gwella gwybyddiaeth: Humby et al. (2020) Psychopharmacology doi: 10.1007 / s00213-020-05496-x
Ymchwilio i ffactorau sy'n dylanwadu ar dueddiad gamblo: Van den Bos et al. (2013) Adolygiadau Niwrowyddoniaeth a Bioymddygiad 37 (10): 2454-71
Assay ymddygiadol llygoden newydd o sylw: Humby et al. (1999) Cyfnodolyn Ewropeaidd Niwrowyddoniaeth 11 (8): 2813-23
6. Nodweddu achosion o syndromau genetig prin gyda nodweddion niwro-ddatblygiadol
Gyda chydweithwyr yng Nghanolfan Ymchwil Feddygol Ryngwladol King Abdullah (KAIMRC) yn Saudi Arabia, rwy'n nodi ac yn disgrifio unigolion sy'n cyflwyno cyflyrau niwrodatblygiadol fel rhan o syndromau genetig prin.
Syndrom Helsmoortel-Van der Aa mewn merch ag anhwylder sbectrwm awtistiaeth: Al-Enezi et al. (2024) Journal of Medical Case Reports 18 (1): 422
Dau achos o syndrom trichohepatoneurodevelopmental a achosir gan amrywiadau yn y genyn CCDC47: Alsubeeh et al. (2024) American Journal of Medical Genetics A e63784
7. Ymchwilio i gysylltiadau rhwng trin y system imiwnedd a'r ymennydd ac ymddygiad
Mae llawer o anhwylderau seiciatrig a niwrolegol yn gysylltiedig â newidiadau yn swyddogaeth y system imiwnedd; fodd bynnag, mae'r cysylltiad rhwng newidiadau i'r system imiwnedd a swyddogaeth yr ymennydd / ymddygiad yn unig yn dechrau cael ei egluro. Mae gennym ddiddordeb yn rôl math penodol o gell imiwnedd (celloedd T rheoleiddiol, Tregs) ar yr ymennydd ac ymddygiad. Mae Tregs yn imiwnosuppressive, a gallant hefyd ysgogi prosesau myelination - rydym yn amau y bydd eu disbyddu yn arwain at ffenoteipiau sy'n gysylltiedig ag anhwylderau hwyliau a seicotig (gan gynnwys yn y cyfnod ôl-enedigol), ac rydym yn defnyddio modelau llygoden i fynd i'r afael â'r rhagdybiaeth hon.
Cyllid
Ysgoloriaeth PhD Sefydliad Ymchwil y Galon Cymru (£109K)
Ysgoloriaethau PhD Agored Ysgol Seicoleg Prifysgol Caerdydd (2 x £77K)
Sefydliad ar gyfer Ichthyosis a Mathau o Groen Cysylltiedig (CYNTAF) USA PI ($ 50K)
Sefydliad Hodge (£112K)
Cyd-PI Cynllun INSPIRE Academi'r Gwyddorau Meddygol/Ymddiriedolaeth Wellcome (£80K)
Ysgoloriaethau Hyfforddiant Doethurol GW4 BioMed MRC
Dyfarniad Cyflymydd Partner Strategol Sêr Cymru II Llywodraeth Cymru Cyd-PI (£68K)
Canolfan MRC ar gyfer Geneteg Niwroseiciatrig a Genomeg Co-PI (£3.4M)
Cynllun Ph.D Niwrowyddoniaeth Integreiddiol Ymddiriedolaeth Wellcome Co-PI (£2.3M)
Gwobr Ymchwil Ymchwilydd Newydd MRC (£430K)
Cymrodoriaeth Cyngor Ymchwil y DU mewn Ymchwil Drosiadol mewn Meddygaeth Arbrofol (£125K)
Grŵp ymchwil
Rwy'n gweithio'n agos gyda'r PI eraill o fewn y Grŵp Geneteg Ymddygiadol ym Mhrifysgol Caerdydd, ac yn goruchwylio, cyd-oruchwylio a mentora, nifer o fyfyrwyr graddedig ac israddedig o fewn y grŵp hwn.
Cydweithwyr ymchwil
Dr Trevor Humby a'r Athro Lawrence Wilkinson (Prifysgol Caerdydd, DU)
Jack Underwood, Kimberley Kendall, Xavier Caseras a George Kirov (Prifysgol Caerdydd, y DU)
Yr Athro Andrew Thompson (Prifysgol Caerdydd, DU)
Dr Ewan Fowler (Prifysgol Caerdydd, DU)
Yr Athro Awen Gallimore (Prifysgol Caerdydd, DU)
Yr Athro Fadil Hannan (Prifysgol Rhydychen, DU)
Yr Athro Evangelia Stergiakouli (Prifysgol Bryste, DU)
Yr Athro Paola Dazzan a Dr Monserrat Fuste-Boadella (Sefydliad Seiciatreg , Seicoleg a Niwrowyddoniaeth, Coleg y Brenin Llundain, DU)
Dr Gareth Richards (Prifysgol Newcastle, DU)
Dr James Turner a Mr Obah Ojarikre (Sefydliad Crick , y DU)
Dr Antoni Gostynski a Dr Otte Borghouts (Prifysgol Maastricht, yr Iseldiroedd)
Dr Tamar Green (Prifysgol Stanford, UDA)
Dr Wafaa Eyaid (Canolfan Ymchwil Feddygol Ryngwladol y Brenin Abdullah, Saudi Arabia)
Yr Athro Dan Rujescu (Prifysgol Halle, yr Almaen)
Dr Tommaso Cassano (Prifysgol Foggia, yr Eidal)
Addysgu
Crynodeb addysgu
CYSYLLTU
- Cydlynydd Modiwl (Seicoleg Biolegol a Gwahaniaethau Unigol, modiwlau Blwyddyn 1 a Meistr mewn Seicoleg a Meistr mewn Iechyd Meddwl)
- Arweinydd Seminar Blwyddyn 2
- Tiwtor Personol
- Goruchwyliwr Prosiect Blwyddyn Olaf
MEDDYG
- Hwylusydd Dysgu Seiliedig ar Achosion Blwyddyn 1
- Llwyfan ar gyfer Hwylusydd Gwyddorau Clinigol
- Darlithydd (Sail Wyddonol Meddygaeth Seicolegol)
- Darlithydd B.Sc Seicoleg a Goruchwyliwr Prosiect
- Tiwtor Personol
- Arweinydd Cynllun INSPIRE
SEICIG / MEDYG
- Goruchwyliwr a Mentor Ph.D
Mae ein herthygl ar integreiddio data ymchwil mewn genomeg ag addysgu mewn biowybodeg ar gael yma: cylchgrawn Cymdeithas Geneteg 87: 30-31
Bywgraffiad
Addysg israddedig
- M.Biochem (Dosbarth 1af) Anrhydedd. (Prifysgol Caerfaddon, 1995-1999)
Addysg ôl-raddedig
- Ph.D (Niwrowyddoniaeth Ymddygiadol) (Prifysgol Caergrawnt, 1999-2003)
- Tystysgrif Ôl-raddedig mewn Addysgu a Dysgu Prifysgol (Modiwl 1) (Prifysgol Caerdydd, 2013)
Cyflogaeth
- 2012-presennol: Uwch Ddarlithydd a Darllenydd, Prifysgol Caerdydd, UK
- 2007-2012: Cymrawd RCUK, Prifysgol Caerdydd, DU
- 2006-2007: Cymrawd 'Gwerth mewn Pobl' Ymddiriedolaeth Wellcome, Prifysgol Caerdydd, UK
- 2003-2006: Gwyddonydd ôl-ddoethurol, Sefydliad Babraham, Caergrawnt, UK
Anrhydeddau a dyfarniadau
Dyfarniadau/pwyllgorau allanol
- Golygydd Cyswllt: Ffiniau mewn Niwrogenomeg a Niwroffarmacoleg
- Aelod o'r Bwrdd Golygyddol: Brain, Behaviour and Immunity (BBI), Endocrinology, World Journal of Psychiatry, Frontiers in Pharmacology
- Aelod o Banel Adolygu Gwyddorau Biolegol a Meddygol y Cyngor Prydeinig
- Aelod o Goleg Adolygu Cymheiriaid Talent UKRI
- Aelod o FWO (Fons Wetenschappelijk Onderzoek) Coleg Adolygu Cymheiriaid ac Aelod o'r Panel Grant
- Cynrychiolydd y Gymdeithas Geneteg Prifysgol Caerdydd
- Cymrawd, Academi Addysg Uwch
- Gwobr 'Rhagoriaeth mewn Addysgu Israddedig' (2020)
- Cymrodoriaeth Gweithdy EMBL
- Enillydd, Gwobr Genedlaethol Ysgrifennu Gwyddoniaeth yr Ymennydd (categori Ymchwilydd)
- Gwobr Florence P. Haseltine am Gyflwyniad Poster Rhagorol, 6ed Cynhadledd Flynyddol Rhyw a Mynegiant Genynnau, Winston-Salem, UDA
- Gwobr Ôl-raddedig Cymdeithas Niwrowyddoniaeth Prydain
- Ysgoloriaeth Oon Khye Beng Ch'hia Tsio ar gyfer Meddygaeth Ataliol Coleg Downing, Prifysgol Caergrawnt
Meysydd goruchwyliaeth
Diddordebau ymchwil ôl-raddedig
Mae gennym ddiddordeb mewn sut, a pham, mae'r rhywiau yn wahanol o ran eu swyddogaeth ymennydd, eu hymddygiad a'u ffisioleg. Mae gennym ddiddordeb arbennig mewn deall y mecanweithiau biolegol sy'n sail i'r risg o gyflyrau niwro-ddatblygiadol fel ADHD ac awtistiaeth (sy'n cael eu diagnosio yn llawer amlach mewn dynion na menywod) ac anhwylderau seiciatrig sy'n gysylltiedig â beichiogrwydd a genedigaeth fel seicosis ôl-enedigol, sy'n effeithio ar fenywod yn fuan ar ôl genedigaeth. Mae gennym ddiddordeb hefyd mewn penderfynyddion iechyd meddwl a chorfforol mewn unigolion â chyflyrau dermatolegol cynhenid.
Rydym yn defnyddio amrywiaeth eang o ddulliau arbrofol mewn modelau cnofilod ac mewn poblogaethau dynol iach a chlinigol, ac yn canolbwyntio'n arbennig ar effeithiau ymennydd ac ymddygiad genynnau ar y cromosomau rhyw (h.y. yr X a'r Y) sy'n cael eu hetifeddu'n anghymesur rhwng dynion a menywod.
Gall ein hastudiaethau fod â goblygiadau pwysig ar gyfer deall pam mae dynion a menywod yn ymddwyn yn wahanol, pam mae'r rhywiau yn wahanol agored i gyflyrau meddygol penodol, ac ar gyfer datblygu therapïau a biofarcwyr rhyw-benodol mwy effeithiol.
Os oes gennych ddiddordeb mewn gwneud cais am PhD, neu i gael rhagor o wybodaeth am fy ymchwil ôl-raddedig, cysylltwch â mi yn uniongyrchol (manylion cyswllt ar gael ar y dudalen 'Trosolwg'), neu cyflwynwch gais ffurfiol.
Myfyrwyr diweddar
Dr Georgina Wren: 'Archwilio'r materion seicolegol a ffisiolegol sy'n gysylltiedig ag ichthyosis sy'n gysylltiedig ag X' - Enillodd Georgina Wobr 'Ymchwilydd Cynyddol' PsyPAG/Cymdeithas Seicolegol Prydain 2022 am ei gwaith PhD cynnar
Dr Freya Shepherd: 'Ymchwilio i gysylltiadau rhwng disbyddu celloedd T rheoleiddiol ac anhwylderau'r sbectrwm seicosis hwyliau' - Dyfarnwyd 'Gwobr Diwylliant Ymchwil Myfyrwyr PGR' 2025 i Freya yng Ngwobrau Rhagoriaeth Myfyrwyr PGR MEDIC am ei gwaith yn galluogi a hyrwyddo ymchwil niwrowyddoniaeth ar draws Prifysgolion ac i'r cyhoedd yn gyffredinol, a gwella enw da (rhyng)genedlaethol Prifysgol Caerdydd
Myfyrwyr presennol
Nina Brett (dechreuodd Hydref 2025): 'Model anifeiliaid cyfunol a dull geneteg ddynol i brofi'r rhagdybiaeth bod secretiad CCN3 annormal a metaboledd calsiwm yn dylanwadu ar risg anhwylder hwyliau ôl-enedigol' - Bydd prosiect Nina yn mynd i'r afael â'r syniad newydd a ddatblygwyd yn ein labordy bod lefelau CCN3 sy'n cylchredeg a/neu metaboledd esgyrn wedi'i newid yn gysylltiedig â ffenoteipiau ymddygiadol ôl-enedigol mewn llygod, a bod genynnau, neu lwybrau genynnau sy'n gysylltiedig â'r mecanweithiau hyn yn cael eu cyfoethogi ar gyfer amrywiadau risg mewn cleifion sydd wedi cael diagnosis o anhwylderau iechyd meddwl ôl-enedigol
Annabel Welsh (i ddechrau Hydref 2026): 'Nodweddu a rheoli heriau iechyd meddwl a chorfforol mewn cyflyrau croen cynhenid' - Bydd prosiect Annabel yn canolbwyntio ar nodi heriau sy'n wynebu unigolion ag ichthyosis (yn enwedig ichthyosis sy'n gysylltiedig ag X) mewn perthynas â'u hiechyd corfforol a meddyliol, a bydd yn ystyried ffyrdd y gellid bodloni'r rhain
Lucie Brocklehurst (i ddechrau ym mis Hydref 2026): 'Nodweddu mecanwaith risg newydd ar gyfer arrhythmias cardiaidd: dull amlddisgyblaethol, trawsrywogaethol' Bydd prosiect Lucie yn ymchwilio i sail fiolegol risg uwch o arrhythmia cardiaidd mewn llygod sydd heb yr ensym steroid sylffatase, a sut y gallai risg arrhythmia fod yn gysylltiedig â straen a phryder; bydd y gwaith anifeiliaid yn cael ei lywio gan, ac yn llywio, gwaith PPIE parhaus gydag unigolion sydd heb steroid sulfatase yr effeithir arnynt gan y cyflwr croen sy'n gysylltiedig â X
Goruchwyliaeth gyfredol
