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Dr Garry Dolton
(e/fe)
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Garry Dolton
Cymrawd Ymchwil
Trosolwyg
Mae fy ymchwil yn canolbwyntio ar ddeall sut mae celloedd T yn adnabod celloedd cleif, gyda phwyslais arbennig ar adnabod celloedd T sy'n adweithiol i glefydau, y derbynyddion celloedd T (TCRs) sy'n cyfryngu adnabyddiaeth, a'r ligandau moleciwlaidd y maent yn eu canfod. Rwy'n datblygu ac yn cymhwyso dulliau arbrofol i ddarganfod penodolrwydd celloedd T prin a datgelu mecanweithiau amrywiol o gydnabyddiaeth imiwnedd, sy'n rhychwantu adnabod celloedd T cyfyngedig clasurol a HLA-annibynnol.
Mae fy ngwaith yn rhychwantu canser, haint ac awtoimiwnedd, gan gyfuno bioleg celloedd T sylfaenol gyda darganfod TCR, adnabod ligand a nodweddu swyddogaethol. Rwy'n arwain ac yn datblygu rhaglenni ymchwil sy'n integreiddio darganfyddiadau arbrofol â dulliau strwythurol, cyfrifiadurol a throsiannol, gan weithio ar y cyd â chydweithwyr ym Mhrifysgol Caerdydd ac yn rhyngwladol. Mae'r dull rhyngddisgyblaethol hwn yn fy ngalluogi i fynd ar drywydd cwestiynau newydd ym maes adnabod imiwnedd wrth ddatblygu strategaethau arbrofol arloesol i fynd i'r afael â nhw.
Trwy ddeall sut mae celloedd T yn gwahaniaethu rhwng celloedd clefyd a chelloedd iach, rwy'n anelu at ddatgelu egwyddorion newydd gwyliadwriaeth imiwnedd a nodi cyfleoedd ar gyfer imiwnotherapïau y genhedlaeth nesaf.
Cyhoeddiad
2026
- Caillaud, M. E. et al. 2026. Optimised procurement of cancer-reactive T-cell receptors from clinical samples. Immunotherapy Advances 6 (1) ltag009. (10.1093/immadv/ltag009)
- Nakama, T. et al., 2026. Position-5-driven reorientation of an immunodominant HLA-A*24:02 SARS-CoV-2 epitope drives universal T-cell escape. JCI Insight 11 (9) e202235. (10.1172/jci.insight.202235)
- Goto, Y. et al., 2026. A probiotic bacterium modulates antitumour γδ T-cell responses in lung cancer. Frontiers in Immunology 17 1750569. (10.3389/fimmu.2026.1750569)
- Thomas, H. et al. 2026. Protocol for MR1-ligand cross-linking to discover metabolite antigens by proteomics. STAR Protocols 7 (1) 104399. (10.1016/j.xpro.2026.104399)
2025
- Schmidlin, T. et al., 2025. MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens. Cell Reports Methods 101120. (10.1016/j.crmeth.2025.101120)
2024
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134 (18) e164535. (10.1172/JCI164535)
2023
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186 (16), pp.3333-3349. E27. (10.1016/j.cell.2023.06.020)
2022
- Goncharov, M. et al., 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9), pp.1017–1019. (10.1038/s41592-022-01578-0)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185 (16), pp.2936-2951. (10.1016/j.cell.2022.07.002)
2021
- Martini, V. et al., 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206 (2) ji2001086. (10.4049/jimmunol.2001086)
2020
- Attaf, M. et al. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11 1587. (10.3389/fimmu.2020.01587)
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) 107885. (10.1016/j.celrep.2020.107885)
- Yeo, L. et al., 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199 (3), pp.263-277. (10.1111/cei.13391)
- Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , pp.178 - 185. (10.1038/s41590-019-0578-8)
- Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 296. (10.3389/fimmu.2020.00296)
- Bagaev, D. V. et al., 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1), pp.D1057-D1062. gkz874. (10.1093/nar/gkz874)
2019
- MacLachlan, B. J. et al., 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52), pp.20246-20258. (10.1074/jbc.RA119.009437)
- Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 5487. (10.1038/s41598-019-41811-z)
- Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 319. (10.3389/fimmu.2019.00319)
2018
- Yeo, L. et al., 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128 (8), pp.3460-3474. (10.1172/JCI120555)
- Zhao, X. et al., 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 2716. (10.1038/s41467-018-05288-0)
- Dolton, G. et al. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 1378. (10.3389/fimmu.2018.01378)
- Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) e1007017. (10.1371/journal.ppat.1007017)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4), pp.1569-1580. (10.1172/JCI91512)
- Rius, C. et al., 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200 (7), pp.2263-2279. (10.4049/jimmunol.1700242)
- Bovay, A. et al., 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2), pp.258-272. (10.1002/eji.201747082)
- Legut, M. et al. 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131 (3), pp.311-322. (10.1182/blood-2017-05-787598)
- Shugay, M. et al., 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1), pp.D419-D427. (10.1093/nar/gkx760)
2017
- Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 1503. (10.3389/fimmu.2017.01503)
- Jones, N. et al., 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8 1516. (10.3389/fimmu.2017.01516)
- Donia, M. et al., 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23 (19), pp.5779-5788. (10.1158/1078-0432.CCR-16-1692)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3), pp.802-813. (10.1074/jbc.M116.741603)
- Tan, M. et al., 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187 (1), pp.124-137. (10.1111/cei.12828)
2016
- Watson, H. A. et al., 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94 (8)(10.1038/icb.2016.45)
- Pageon, S. V. et al., 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113 (37), pp.E5454-E5463. (10.1073/pnas.1607436113)
- Laugel, B. et al. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197 (3), pp.971-982. (10.4049/jimmunol.1501402)
- Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6), pp.573-582. (10.1038/icb.2016.12)
- Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6), pp.1172-1181. (10.1016/j.jid.2016.01.033)
- Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126 (6), pp.2191-2204. (10.1172/JCI85679)
- Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17), pp.8951-8959. (10.1074/jbc.M115.707414)
- Theaker, S. M. et al. 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp.43-50. (10.1016/j.jim.2016.01.014)
2015
- Holland, C. J. et al., 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12), pp.5827-5836. (10.4049/jimmunol.1402787)
- Dolton, G. M. et al. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1), pp.11-22. (10.1111/imm.12499)
- Skowera, A. et al., 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3), pp.916-925. (10.2337/db14-0332)
- Tungatt, K. et al. 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1), pp.463-474. (10.4049/jimmunol.1401785)
- Knight, R. R. et al., 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1), pp.100-107. (10.1111/cei.12436)
- Neller, M. A. et al., 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp.625-633. (10.1038/icb.2015.17)
2014
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4), pp.471-483. (10.1016/j.chom.2014.03.003)
- Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1), pp.47-63. (10.1111/cei.12339)
2013
- Eukeruche-Makinde, J. et al., 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7), pp.1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7), pp.1112-1123. (10.1182/blood-2012-06-437202)
2012
- Ekeruche-Makinde, J. et al., 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44), pp.37269-37281. (10.1074/jbc.M112.386409)
- Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2), pp.1168-1177. (10.1074/jbc.M111.289488)
- Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3), pp.283-289. (10.1038/ni.2206)
2011
- Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2), pp.654-663. (10.4049/jimmunol.1003941)
- Nunes, C. T. et al. 2011. A novel tumor antigen derived from enhanced degradation of Bax protein in human cancers. Cancer Research 71 (16), pp.5435-5444. (10.1158/0008-5472.CAN-11-0393)
2010
- Cuff, S. et al. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184 (2), pp.607-614. (10.4049/jimmunol.0804089)
- Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) e1001198. (10.1371/journal.ppat.1001198)
2008
- Dolton, G. M. 2008. Role of SHP-1 in in vivo CD8+ T cell responses to antigenic stimulation. PhD Thesis , Cardiff University.
2007
- Sathish, J. G. et al., 2007. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. Journal of immunology 178 , pp.330-337.
Articles
- Caillaud, M. E. et al. 2026. Optimised procurement of cancer-reactive T-cell receptors from clinical samples. Immunotherapy Advances 6 (1) ltag009. (10.1093/immadv/ltag009)
- Nakama, T. et al., 2026. Position-5-driven reorientation of an immunodominant HLA-A*24:02 SARS-CoV-2 epitope drives universal T-cell escape. JCI Insight 11 (9) e202235. (10.1172/jci.insight.202235)
- Goto, Y. et al., 2026. A probiotic bacterium modulates antitumour γδ T-cell responses in lung cancer. Frontiers in Immunology 17 1750569. (10.3389/fimmu.2026.1750569)
- Thomas, H. et al. 2026. Protocol for MR1-ligand cross-linking to discover metabolite antigens by proteomics. STAR Protocols 7 (1) 104399. (10.1016/j.xpro.2026.104399)
- Schmidlin, T. et al., 2025. MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens. Cell Reports Methods 101120. (10.1016/j.crmeth.2025.101120)
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134 (18) e164535. (10.1172/JCI164535)
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186 (16), pp.3333-3349. E27. (10.1016/j.cell.2023.06.020)
- Goncharov, M. et al., 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9), pp.1017–1019. (10.1038/s41592-022-01578-0)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185 (16), pp.2936-2951. (10.1016/j.cell.2022.07.002)
- Martini, V. et al., 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206 (2) ji2001086. (10.4049/jimmunol.2001086)
- Attaf, M. et al. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11 1587. (10.3389/fimmu.2020.01587)
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) 107885. (10.1016/j.celrep.2020.107885)
- Yeo, L. et al., 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199 (3), pp.263-277. (10.1111/cei.13391)
- Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , pp.178 - 185. (10.1038/s41590-019-0578-8)
- Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 296. (10.3389/fimmu.2020.00296)
- Bagaev, D. V. et al., 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1), pp.D1057-D1062. gkz874. (10.1093/nar/gkz874)
- MacLachlan, B. J. et al., 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52), pp.20246-20258. (10.1074/jbc.RA119.009437)
- Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 5487. (10.1038/s41598-019-41811-z)
- Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 319. (10.3389/fimmu.2019.00319)
- Yeo, L. et al., 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128 (8), pp.3460-3474. (10.1172/JCI120555)
- Zhao, X. et al., 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 2716. (10.1038/s41467-018-05288-0)
- Dolton, G. et al. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 1378. (10.3389/fimmu.2018.01378)
- Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) e1007017. (10.1371/journal.ppat.1007017)
- Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4), pp.1569-1580. (10.1172/JCI91512)
- Rius, C. et al., 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200 (7), pp.2263-2279. (10.4049/jimmunol.1700242)
- Bovay, A. et al., 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2), pp.258-272. (10.1002/eji.201747082)
- Legut, M. et al. 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131 (3), pp.311-322. (10.1182/blood-2017-05-787598)
- Shugay, M. et al., 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1), pp.D419-D427. (10.1093/nar/gkx760)
- Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 1503. (10.3389/fimmu.2017.01503)
- Jones, N. et al., 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8 1516. (10.3389/fimmu.2017.01516)
- Donia, M. et al., 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23 (19), pp.5779-5788. (10.1158/1078-0432.CCR-16-1692)
- Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3), pp.802-813. (10.1074/jbc.M116.741603)
- Tan, M. et al., 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187 (1), pp.124-137. (10.1111/cei.12828)
- Watson, H. A. et al., 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94 (8)(10.1038/icb.2016.45)
- Pageon, S. V. et al., 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113 (37), pp.E5454-E5463. (10.1073/pnas.1607436113)
- Laugel, B. et al. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197 (3), pp.971-982. (10.4049/jimmunol.1501402)
- Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6), pp.573-582. (10.1038/icb.2016.12)
- Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6), pp.1172-1181. (10.1016/j.jid.2016.01.033)
- Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126 (6), pp.2191-2204. (10.1172/JCI85679)
- Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17), pp.8951-8959. (10.1074/jbc.M115.707414)
- Theaker, S. M. et al. 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp.43-50. (10.1016/j.jim.2016.01.014)
- Holland, C. J. et al., 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12), pp.5827-5836. (10.4049/jimmunol.1402787)
- Dolton, G. M. et al. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1), pp.11-22. (10.1111/imm.12499)
- Skowera, A. et al., 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3), pp.916-925. (10.2337/db14-0332)
- Tungatt, K. et al. 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1), pp.463-474. (10.4049/jimmunol.1401785)
- Knight, R. R. et al., 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1), pp.100-107. (10.1111/cei.12436)
- Neller, M. A. et al., 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp.625-633. (10.1038/icb.2015.17)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4), pp.471-483. (10.1016/j.chom.2014.03.003)
- Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1), pp.47-63. (10.1111/cei.12339)
- Eukeruche-Makinde, J. et al., 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7), pp.1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7), pp.1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche-Makinde, J. et al., 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44), pp.37269-37281. (10.1074/jbc.M112.386409)
- Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2), pp.1168-1177. (10.1074/jbc.M111.289488)
- Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3), pp.283-289. (10.1038/ni.2206)
- Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2), pp.654-663. (10.4049/jimmunol.1003941)
- Nunes, C. T. et al. 2011. A novel tumor antigen derived from enhanced degradation of Bax protein in human cancers. Cancer Research 71 (16), pp.5435-5444. (10.1158/0008-5472.CAN-11-0393)
- Cuff, S. et al. 2010. Antigen specificity determines the pro- or antitumoral nature of CD8+ T cells. The Journal of Immunology 184 (2), pp.607-614. (10.4049/jimmunol.0804089)
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- Sathish, J. G. et al., 2007. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. Journal of immunology 178 , pp.330-337.
Thesis
- Dolton, G. M. 2008. Role of SHP-1 in in vivo CD8+ T cell responses to antigenic stimulation. PhD Thesis , Cardiff University.
