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Dr Amal Gadalla
Postdoctoral Research Associate (with Prof Angela Casini)
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
I am newly appointed research associate at the Division of Population Medicine. My wide research interest is dynamics, transmission and control of infectious diseases using bioinformatics and statistical modelling tools. I have particular research interest in drug resistance. I am currently investigating immunological markers as predictors for uncomplicated urinary tract infections in females. Also I will be working on aspects of antimicrobial resistance in common bacterial infections in primary care setting using anonymized and linked routine data available from resources such as Secure Anonymised Information Linkage (SAIL), Clinical Practice Research Datalink (CPRD), Hospital Episode Statistics (HES), Biobank and Datastore.
My academic background is microbiology, molecular biology and epidemiology and I am very interested in bioinformatics and statistical analyses, specially modelling and machine learning classification methods.
I am very keen to network with people with similar interest/experience.
Cyhoeddiad
2022
- Gadalla, A. et al. 2022. Antibiotic consumption and time to recovery from uncomplicated urinary tract infection: secondary analysis of observational data from a point-of-care test trial. British Journal of General Practice 72(725), pp. 882-890. (10.3399/BJGP.2022.0011)
- Al Mahrouqi, S. et al. 2022. Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity. PeerJ – the Journal of Life & Environmental Sciences 10, article number: e13645. (10.7717/peerj.13645)
- Al-Mahrouqi, S. et al. 2022. Dynamics of Mycobacterium tuberculosis Lineages in Oman, 2009 to 2018. Pathogens 11(5), article number: 541. (10.3390/pathogens11050541)
2021
- Gadalla, A. A. H. et al. 2021. Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages. Scientific Reports 11, article number: 19118. (10.1038/s41598-021-97456-4)
2020
- Awad, H. et al. 2020. Dynamics and within-host interaction of Theileria lestoquardi and T. ovis among naive sheep in Oman. Scientific Reports 10(1), article number: 19802. (10.1038/s41598-020-76844-2)
- Al-Rumhi, A. et al. 2020. Influx of diverse, drug resistant and transmissible Plasmodium falciparum into a malaria-free setting in Qatar. BMC Infectious Diseases 20(1), article number: 413. (10.1186/s12879-020-05111-6)
2019
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Bakhiet, A. M. A. et al. 2019. Evolution of Plasmodium falciparum drug resistance genes following artemisinin combination therapy in Sudan. Transactions of The Royal Society of Tropical Medicine and Hygiene 113(11), pp. 693-700. (10.1093/trstmh/trz059)
- Schneider, P., Babiker, H. A., Gadalla, A. A. H. and Reece, S. E. 2019. Evolutionary sex allocation theory explains sex ratios in natural Plasmodium falciparum infections. International Journal for Parasitology 49(8), pp. 601-604. (10.1016/j.ijpara.2019.04.001)
2018
- Abdelraheem, M. H. et al. 2018. Genetic diversity and transmissibility of imported Plasmodium vivax in Qatar and three countries of origin. Scientific Reports 8, article number: 8870. (10.1038/s41598-018-27229-z)
2016
- Gadalla, A. A. et al. 2016. Associations between season and gametocyte dynamics in chronic plasmodium falciparum infections. Plos One 11(11), article number: e0166699. (10.1371/journal.pone.0166699)
2015
- Schneider, P. et al. 2015. Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR. Molecular and Biochemical Parasitology 199(1-2), pp. 29-33. (10.1016/j.molbiopara.2015.03.006)
- Gadalla, N. B. et al. 2015. Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients. Journal of Antimicrobial Chemotherapy 70(1), pp. 116-123. (10.1093/jac/dku358)
2013
- Babiker, H. A., Gadalla, A. A. and Ranford-Cartwright, L. C. 2013. The role of asymptomatic P. falciparum parasitaemia in the evolution of antimalarial drug resistance in areas of seasonal transmission. Drug Resistance Updates 16(1-2), pp. 1-9. (10.1016/j.drup.2013.02.001)
2011
- Gadalla, N. B. et al. 2011. Increased pfmdr1 copy number and sequence polymorphisms in lasmodium falciparum Isolates from Sudanese malaria patients treated with artemether-lumefantrine. Antimicrobial Agents and Chemotherapy 55(11), pp. 5408-5411. (10.1128/AAC.05102-11)
Articles
- Gadalla, A. et al. 2022. Antibiotic consumption and time to recovery from uncomplicated urinary tract infection: secondary analysis of observational data from a point-of-care test trial. British Journal of General Practice 72(725), pp. 882-890. (10.3399/BJGP.2022.0011)
- Al Mahrouqi, S. et al. 2022. Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity. PeerJ – the Journal of Life & Environmental Sciences 10, article number: e13645. (10.7717/peerj.13645)
- Al-Mahrouqi, S. et al. 2022. Dynamics of Mycobacterium tuberculosis Lineages in Oman, 2009 to 2018. Pathogens 11(5), article number: 541. (10.3390/pathogens11050541)
- Gadalla, A. A. H. et al. 2021. Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages. Scientific Reports 11, article number: 19118. (10.1038/s41598-021-97456-4)
- Awad, H. et al. 2020. Dynamics and within-host interaction of Theileria lestoquardi and T. ovis among naive sheep in Oman. Scientific Reports 10(1), article number: 19802. (10.1038/s41598-020-76844-2)
- Al-Rumhi, A. et al. 2020. Influx of diverse, drug resistant and transmissible Plasmodium falciparum into a malaria-free setting in Qatar. BMC Infectious Diseases 20(1), article number: 413. (10.1186/s12879-020-05111-6)
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Bakhiet, A. M. A. et al. 2019. Evolution of Plasmodium falciparum drug resistance genes following artemisinin combination therapy in Sudan. Transactions of The Royal Society of Tropical Medicine and Hygiene 113(11), pp. 693-700. (10.1093/trstmh/trz059)
- Schneider, P., Babiker, H. A., Gadalla, A. A. H. and Reece, S. E. 2019. Evolutionary sex allocation theory explains sex ratios in natural Plasmodium falciparum infections. International Journal for Parasitology 49(8), pp. 601-604. (10.1016/j.ijpara.2019.04.001)
- Abdelraheem, M. H. et al. 2018. Genetic diversity and transmissibility of imported Plasmodium vivax in Qatar and three countries of origin. Scientific Reports 8, article number: 8870. (10.1038/s41598-018-27229-z)
- Gadalla, A. A. et al. 2016. Associations between season and gametocyte dynamics in chronic plasmodium falciparum infections. Plos One 11(11), article number: e0166699. (10.1371/journal.pone.0166699)
- Schneider, P. et al. 2015. Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR. Molecular and Biochemical Parasitology 199(1-2), pp. 29-33. (10.1016/j.molbiopara.2015.03.006)
- Gadalla, N. B. et al. 2015. Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients. Journal of Antimicrobial Chemotherapy 70(1), pp. 116-123. (10.1093/jac/dku358)
- Babiker, H. A., Gadalla, A. A. and Ranford-Cartwright, L. C. 2013. The role of asymptomatic P. falciparum parasitaemia in the evolution of antimalarial drug resistance in areas of seasonal transmission. Drug Resistance Updates 16(1-2), pp. 1-9. (10.1016/j.drup.2013.02.001)
- Gadalla, N. B. et al. 2011. Increased pfmdr1 copy number and sequence polymorphisms in lasmodium falciparum Isolates from Sudanese malaria patients treated with artemether-lumefantrine. Antimicrobial Agents and Chemotherapy 55(11), pp. 5408-5411. (10.1128/AAC.05102-11)
- Bakhiet, A. M. A. et al. 2019. Evolution of Plasmodium falciparum drug resistance genes following artemisinin combination therapy in Sudan. Transactions of The Royal Society of Tropical Medicine and Hygiene 113(11), pp. 693-700. (10.1093/trstmh/trz059)
- Schneider, P., Babiker, H. A., Gadalla, A. A. H. and Reece, S. E. 2019. Evolutionary sex allocation theory explains sex ratios in natural Plasmodium falciparum infections. International Journal for Parasitology 49(8), pp. 601-604. (10.1016/j.ijpara.2019.04.001)
- Abdelraheem, M. H. et al. 2018. Genetic diversity and transmissibility of imported Plasmodium vivax in Qatar and three countries of origin. Scientific Reports 8, article number: 8870. (10.1038/s41598-018-27229-z)
Ymchwil
My current research focuses on:
- Antimicrobial resistance
- Urinary tract infection
- Biomarkers
- Chronic obstructive respiratory disease
Addysgu
Addysgu ac asesu:
- Arweinydd Rhifedd Medi 2022 – cyfredol: modiwl sydd wedi'i integreiddio'n fertigol wedi'i gyflwyno ar draws myfyrwyr meddygol blwyddyn 1 i flwyddyn 5 i gefnogi eu dealltwriaeth o rifau, hafaliadau, cyfrifiadau presgripsiwn a dadansoddi data ymchwil. Mae'r modiwl hefyd yn cefnogi myfyrwyr rhaglen ryng-golegol ac ôl-raddedigion yn yr Ysgol Meddygaeth, Prifysgol Caerdydd, y DU.
- Signalau Cell a2il Arweinydd Tiwtorial Messenger Medi 2022 – cyfredol: tiwtorialau wyneb yn wyneb ac ar-lein fel rhan o fodiwl ME1101. Myfyrwyr: Myfyrwyr Blwyddyn 1
- Dysgu Seiliedig ar Achos (ME1106 ac ME2100) hwyluso Ionawr 2022 – cyfredol: myfyrwyr meddygol blwyddyn 1 a blwyddyn 2.
- Gradd BSc Rhyng-gyfrifedig Epidemioleg Glinigol (ME3064) 2018 – cyfredol: ar gyfer myfyrwyr israddedig meddygaeth, Prifysgol Caerdydd. Pwnc addysgu "Defnyddio 'omics mewn diagnosis ac ymchwil clefydau heintus", yna asesu prosiectau a chyflwyniadau myfyrwyr.
- Llwyfan ar gyfer modiwl Gwyddorau Clinigol (ME1101) 2018 - cyfredol: Cyflwyno amrywiol gwyddorau biofeddygol darlithoedd tiwtorialau o fewn y: strwythur a swyddogaeth celloedd, ensymau, signalau celloedd, meddygaeth sy'n seiliedig ar dystiolaeth, imiwnoleg gymhwysol, bioleg foleciwlaidd, haematoleg a microbioleg. Myfyrwyr: Myfyrwyr Blwyddyn 1 a 2 Meddygaeth.
Bywgraffiad
Qualifications
- 2015 – PhD Biochemistry and Molecular Biology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Thesis title: "Influence of season, drug resistance, genetic complexity and anti-malarials on persistence and transmission of the malaria parasite Plasmodium falciparum"
- 2008 – MSc Biomedical Sciences (Immunology), Sudan Academy for Sciences, Khartoum, Sudan. Thesis title: "IgG profile against MSP3 antigen in asymptomatic carriers of Plasmodium falciparum in Eastern Sudan"
- 2004 – BSc (1st Class Honours) Medical Laboratory Sciences (major Microbiology), Faculty of Medical Laboratory Sciences, University of Gezira, Sudan.
Career
Previous posts
- 2016 - 2017 Technical expert,International Atomic Energy Agency, mission to Sultan Qaboos University, Muscat, Oman.
- 2014 - 2016 Research fellow, Biochemistry and Molecular Biology, Sultan Qaboos University, Muscat, Oman.
- 2004 - 2010. Researcher, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan.
Previous projects
- Diversity and transmission potential of imported malaria to malaria-free countries, Sultan Qaboos University, Muscat, Oman.
- Theileria parasite in Oman, molecular biology and disease, Sultan Qaboos University, Muscat, Oman.
- Identification of Plasmodium falciparum early gametocyte-specific expression in natural infections. Sultan Qaboos University, Muscat, Oman. In collaboration with University of Edinburgh, Edinburgh, UK, Queensland Institute of Medical Research, Queensland, Australia and Istituto Superiore di Sanità, Italy.
- Validation of the use of isotope-based molecular techniques in malaria control. Tropical Medicine Research Institute, Khartoum, Sudan.
- Molecular genetics of P. falciparum isolates in Sudan: Gametocytaemia and drug resistance markers. Tropical Medicine Research Institute, Khartoum, Sudan
Anrhydeddau a dyfarniadau
- 2017 - Jamal Elnefeidi Award for Research on Malaria, Sudan
- 2016 – American Society of Tropical Medicine and Hygiene (ASTMH) Travel Award
- 2016 – European Molecular Biology Laboratory (EMBL), Advanced Training Centre Corporate Partnership Programme (CPP) Fellowship Travel Award
- 2016 – British Society of Parasitology Spring Meeting Travel Award
- 2013 – 6th Multilateral Initiative on Malaria Pan-African Malaria Conference Travel Award
- 2012 – Training fellowship award. International Atomic Energy Agency (IAEA)
- 2010 – PhD scholarship, Sultan Qaboos University, Muscat, Oman.
- 2007 – MSc scholarship, Sudan Academy for Sciences, Khartoum, Sudan
Aelodaethau proffesiynol
- International Society of Infectious Diseases, member
- SM Tropical Medicine Journal, member of the Editorial Board
- British Society of Parasitology, member
Pwyllgorau ac adolygu
adolygydd cyfnodolyn, PloS ONE
Ymgysylltu
Ymgysylltu â'r cyfryngau
- Darllediad radio: trafodaethau 9 cyfres (iaith Arabeg ) am achosion Covid-19 i gynyddu ymwybyddiaeth y cyhoedd am achosion Covid-19. Cychwynnwr a chyflwynydd: Dr Noon Abdelgafar, Caerlŷr, y DU. Grŵp o wyddonwyr meddygol rhyngwladol a chlinigwyr sy'n gweithio ac yn byw yn y DU, Ffrainc, UDA, Emiradau Arabaidd Unedig a Saudi Arabia sy'n wreiddiol o Sudan ochr yn ochr â chlinigwyr a gwyddonydd rheng flaen Covid-19 sy'n gweithio yn Sudan.
- Tymor malaria: Q&A gydag Amal Gadalla. 2017. Iechyd Byd-eang nawr. Ysgol Iechyd Cyhoeddus Johns Hopkins Bloomberg https://www.globalhealthnow.org/2017-01/malaria-season-qa-amal-gadalla?utm_source=Global+Health+NOW+Main+List&utm_campaign=3b9bce0ed9-EMAIL_CAMPAIGN_2017_01_04&utm_medium=email&utm_term=0_8d0d062dbd-3b9bce0ed9-860291
- Cyfweliad radio yn tynnu sylw at y cyhoeddiad ar gametocytes tymhorol deinamig a'i berthnasedd i epidemigau malaria yn Sudan, 22 Ionawr 2017, Rhaglen Fakhr Beladi (Pride of My Country), Fakhr Beladi Broadcast, Khartoum, Sudan.
Contact Details
GadallaA1@caerdydd.ac.uk
+44 29206 88102
Adeilad Cochrane, Ystafell 5th floor, Parc y Mynydd Bychan, Caerdydd, CF14 4YU
+44 29206 88102
Adeilad Cochrane, Ystafell 5th floor, Parc y Mynydd Bychan, Caerdydd, CF14 4YU