Dr Oleg Gerasimenko
Darllenydd
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Prosiectau cyfredol:
1. Ymchwilio i batholegau celloedd imiwnedd mewn pancreas exocrine defnyddio mewn paratoadau situ a microsgopeg dau ffoton.
2. Astudiaethau patholegau sy'n arwain at sefydlu pancreatitis acíwt. Disgrifiwyd prif ddulliau mewn adolygiadau a gyhoeddwyd yn ddiweddar yn Adolygiadau Ffisiolegol (Petersen et al 2021) ac mewn Calsiwm Cell (Gerasimenko & Gerasimenko 2023).
3. Gwella triniaethau asparaginase ar gyfer Plentyndod ALL.
Rolau
Arweinydd Modiwl: Datblygiadau BI3355 mewn Ffisioleg a Pathoffisioleg
Cydlynydd Asesu: BI3253 Bioleg a Delweddu Celloedd Uwch.
Oes gennych chi ddiddordeb mewn ymuno â'm labordy fel myfyriwr ôl-raddedig hunan-ariannu neu bostdoc/cymrodyr? Cysylltwch â mi drwy e-bost.
Cyhoeddiad
2024
- Gerasimenko, O. V. and Gerasimenko, J. V. 2024. The role of CFTR in diabetes‐induced pancreatic ductal dysfunction. The Journal of Physiology 602(6), pp. 993-994. (10.1113/jp286338)
- Lewis, S., Evans, D., Tsugorka, T., Peng, S., Stauderman, K., Gerasimenko, O. and Gerasimenko, J. 2024. Combination of the CRAC channel inhibitor CM4620 and galactose as a potential therapy for acute pancreatitis. Function 5(4), article number: zqae017. (10.1093/function/zqae017)
2023
- Famili, D. T. et al. 2023. Pancreatitis in RYR1-related disorders. Neuromuscular Disorders 33(10), pp. 769-775. (10.1016/j.nmd.2023.09.003)
- Gerasimenko, J. V. and Gerasimenko, O. V. 2023. The role of Ca2+ signalling in the pathology of exocrine pancreas. Cell Calcium 112, article number: 102740. (10.1016/j.ceca.2023.102740)
- Gerasimenko, J. V. and Gerasimenko, O. V. 2023. Ca 2+ signaling and ATP production in pancreatic cancer. Function 5(1), article number: zqad067. (10.1093/function/zqad067)
2022
- Kusiak, A. A. et al. 2022. Activation of pancreatic stellate cells attenuates intracellular Ca 2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites. Cell Death and Disease 13(8), article number: 744. (10.1038/s41419-022-05186-w)
- Gerasimenko, O. V. and Gerasimenko, J. V. 2022. CRAC channel inhibitors in pancreatic pathologies. Journal of Physiology 600(7), pp. 1597-1598. (10.1113/JP282826)
- Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2022. SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ. Function 3(2) (10.1093/function/zqac002)
2021
- Petersen, O. H., Gerasimenko, J., Gerasimenko, O. V., Gryshchenko, O. and Peng, S. 2021. The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas. Physiological Reviews 101(4), pp. 1691-1744. (10.1152/physrev.00003.2021)
2020
- Gryshchenko, O., Gerasimenko, J., Petersen, O. H. and Gerasimenko, O. V. 2020. Calcium signaling in pancreatic immune cells in situ. Function 2(1), article number: zqaa026. (10.1093/function/zqaa026)
- Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2020. Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+ and NAADP. Function 1(1), article number: zqaa003. (10.1093/function/zqaa003)
2019
- Jakubowska, M. A. et al. 2019. ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells. British Journal of Pharmacology 176(22), pp. 4402-4415. (10.1111/bph.14505)
2018
- Peng, S., Gerasimenko, J. V., Tsugorka, T. M., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2018. Galactose protects against cell damage in mouse models of acute pancreatitis. Journal of Clinical Investigation 128(9), pp. 3769-3778. (10.1172/JCI94714)
- Gryshchenko, O., Gerasimenko, J., Peng, S., Gerasimenko, O. V. and Petersen, O. H. 2018. Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. Journal of Physiology 596(14), pp. 2663-2678. (10.1113/JP275395)
- Vervliet, T., Gerasimenko, J. V., Ferdek, P. E., Jakubowska, M. A., Petersen, O. H., Gerasimenko, O. V. and Bultynck, G. 2018. BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis. Cell Death Discovery 4, article number: 58. (10.1038/s41420-018-0054-5)
- Gerasimenko, J. V., Peng, S., Tsugorka, T. and Gerasimenko, O. V. 2018. Ca 2+ signalling underlying pancreatitis. Cell Calcium 70, pp. 95-101. (10.1016/j.ceca.2017.05.010)
2017
- Ferdek, P. E., Jakubowska, M. A., Polina, N., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2017. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death and Disease 8, article number: e2640. (10.1038/cddis.2017.41)
- Bittremieux, M. et al. 2017. DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store. Cell Calcium 62 (10.1016/j.ceca.2017.01.015)
2016
- Ferdek, P. E., Jakubowska, M. A., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. Journal of Physiology 594(21), pp. 6147-6164. (10.1113/JP272774)
- Peng, S., Gerasimenko, J. V., Tsugorka, T., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2016. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 371(1700), article number: 20150423. (10.1098/rstb.2015.0423)
- Jakubowska, M. A., Ferdek, P. E., Gerasimenko, O. V., Gerasimenko, J. V. and Petersen, O. H. 2016. Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biology 6(8), article number: 160149. (10.1098/rsob.160149)
- Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Calcium signalling in pancreatic stellate cells: mechanisms and potential roles. Cell Calcium 59(2-3), pp. 140-144. (10.1016/j.ceca.2016.02.003)
- Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Ca2+ signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+ channel blockade. Journal of Physiology 594(2), pp. 281-293. (10.1113/JP271468)
2015
- Gerasimenko, J. et al. 2015. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Cell Calcium 58(3), pp. 237-245. (10.1016/j.ceca.2015.05.005)
2014
- Gerasimenko, J. V., Peng, S. and Gerasimenko, O. V. 2014. Role of acidic stores in secretory epithelia. Cell Calcium 55(6), pp. 346-354. (10.1016/j.ceca.2014.04.002)
- Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2014. Monitoring of intra-ER free Ca2+. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 3(3), pp. 63-71. (10.1002/wmts.106)
- Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2014. The role of Ca2+ in the pathophysiology of pancreatitis. The Journal of Physiology 592(2), pp. 269-280. (10.1113/jphysiol.2013.261784)
2013
- Gerasimenko, J. V. et al. 2013. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110(32), pp. 13186-13191. (10.1073/pnas.1300910110)
2012
- Ferdek, P., Gerasimenko, J. V., Peng, S., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2012. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Current Biology 22(13), pp. 1241-1246. (10.1016/j.cub.2012.05.002)
- Gerasimenko, O. V., Petersen, O. H. and Gerasimenko, J. V. 2012. Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation [Editorial]. Expert Review of Gastroenterology & Hepatology 6(2), pp. 129-131. (10.1586/EGH.12.5)
- Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2012. The war within - unraveling the molecular causes of acute pancreatitis - a potentially deadly disease in which the pancreas essentially digests itself - is yielding clues to how it might be treated. The Scientist 26(2), pp. 40-44.
- Gerasimenko, O. V. and Gerasimenko, J. V. 2012. Mitochondrial function and malfunction in the pathophysiology of pancreatitis. Pflugers Archiv European Journal of Physiology 464(1), pp. 89-99. (10.1007/s00424-012-1117-8)
2011
- Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2011. Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports(3), article number: 15. (10.3410/M3-15)
- Petersen, O. H., Gerasimenko, O. V., Tepikin, A. and Gerasimenko, J. V. 2011. Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells. Cell Calcium 50(2), pp. 193-199. (10.1016/j.ceca.2011.02.010)
- Booth, D. et al. 2011. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140(7), pp. 2116-2125. (10.1053/j.gastro.2011.02.054)
- Gerasimenko, J. V. et al. 2011. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 108(14), pp. 5873-5878. (10.1073/pnas.1016534108)
2010
- Voronina, S. G. et al. 2010. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5), pp. 1976-1987. (10.1053/j.gastro.2010.01.037)
- Gerasimenko, O. V. and Gerasimenko, J. V. 2010. Two-photon permeabilization and calcium measurements in cellular organelles. In: Live Cell Imaging: Methods and Protocols., Vol. 591. Methods in Molecular Biology Vol. 2. Springer, pp. 201-210., (10.1007/978-1-60761-404-3_12)
2009
- Lur, G. et al. 2009. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19(19), pp. 1648-1653. (10.1016/j.cub.2009.07.072)
- Baumgartner, H. K. et al. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. Journal of Biological Chemistry 284(31), pp. 20796-20803. (10.1074/jbc.M109.025353)
- Petersen, O. H., Tepikin, A. V., Gerasimenko, J. V., Gerasimenko, O. V., Sutton, R. and Criddle, D. N. 2009. Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis. Cell Calcium 45(6), pp. 634-642. (10.1016/j.ceca.2009.02.005)
- Gerasimenko, J. V. et al. 2009. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 106(26), pp. 10758-10763. (10.1073/pnas.0904818106)
- Fedirko, N., Gerasimenko, J. V., Tepikin, A. V. and Gerasimenko, O. V. 2009. Regulation of early response genes in pancreatic acinar cells: external calcium and nuclear calcium signalling aspects. Acta Physiologica 195(1), pp. 51-60. (10.1111/j.1748-1716.2008.01935.x)
2008
- Barrow, S. L. et al. 2008. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Archiv - European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)
- Chvanov, M. et al. 2008. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Archiv-European Journal of Physiology 457(2), pp. 505-517. (10.1007/s00424-008-0529-y)
- Murphy, J. A. et al. 2008. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135(2), pp. 632-641. (10.1053/j.gastro.2008.05.026)
2007
- Baumgartner, H. K. et al. 2007. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(1), pp. G296-G307. (10.1152/ajpgi.00103.2007)
- Voronina, S. G., Sherwood, M. W., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2007. Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(6), pp. G1333-G1338. (10.1152/ajpgi.00275.2007)
- Criddle, D. N. et al. 2007. Calcium signalling and pancreatic cell death: apoptosis or necrosis?. Cell Death and Differentiation 14(7), pp. 1285-1294. (10.1038/sj.cdd.4402150)
- Sherwood, M. W. et al. 2007. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 104(13), pp. 5674-5679. (10.1073/pnas.0700951104)
2006
- Criddle, D. N. et al. 2006. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. Journal of Biological Chemistry 281(52), pp. 40485-40492. (10.1074/jbc.M607704200)
- Sherwood, M. W., Barrow, S. L., Dolman, N. J., Gerasimenko, O. V., Voronina, S. G. and Tepikin, A. V. 2006. Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels. Biochemical Society Transactions 34(3), pp. 381-384. (10.1042/BST0340381)
- Gerasimenko, J. V., Flowerdew, S. E., Voronina, S. G., Sukhomlin, T. K., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2006. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. Journal of Biological Chemistry 281(52), pp. 40154-40163. (10.1074/jbc.M606402200)
- Chvanov, M., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2006. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO Journal 25(13), pp. 3024. (10.1038/sj.emboj.7601207)
- Gerasimenko, J. V., Sherwood, M., Tepikin, A., Petersen, O. H. and Gerasimenko, O. V. 2006. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. Journal of Cell Science 119(2), pp. 226-238. (10.1242/jcs.02721)
- Yu, L. G. et al. 2006. Galectin-3 interaction with Thomsen-Friedenreich Disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. Journal of Biological Chemistry 282(1), pp. 773-781. (10.1074/jbc.M606862200)
- Burdakov, D. et al. 2006. Tandem-Pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron -Cambridge Ma- 50(5), pp. 711-722. (10.1016/j.neuron.2006.04.032)
2005
- Dolman, N. J., Gerasimenko, J. V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H. and Tepikin, A. V. 2005. Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. Journal of Biological Chemistry 280(16), pp. 15794-15799. (10.1074/jbc.M412694200)
- Voronina, S. G., Gryshchenko, O. V., Gerasimenko, O. V., Green, A. K., Petersen, O. H. and Tepikini, A. V. 2005. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. Journal of Biological Chemistry 280(3), pp. 1764-1770. (10.1074/jbc.M410230200)
- Burdakov, D., Gerasimenko, O. V. and Verkhratsky, A. 2005. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. Journal of Neuroscience 25(9), pp. 2429-2433. (10.1523/JNEUROSCI.4925-04.2005)
- Gerasimenko, O. V. and Tepikin, A. 2005. How to measure Ca2+ in cellular organelles?. Cell Calcium 38(3-4), pp. 201-211. (10.1016/j.ceca.2005.06.025)
- Watson, A. J. et al. 2005. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 129(3), pp. 902-912. (10.1053/j.gastro.2005.06.015)
2004
- Voronina, S. G., Barrow, S. L., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2004. Effects of secretagogues and gile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating ΔΨm. Journal of Biological Chemistry 279(26), pp. 27327-27338. (10.1074/jbc.M311698200)
- Gerasimenko, O. V. and Gerasimenko, J. V. 2004. New aspects of nuclear calcium signalling. Journal of Cell Science 117(15), pp. 3087-3094. (10.1242/jcs.01295)
2003
- Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2003. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Journal of Cell Biology 163(2), pp. 271-282. (10.1083/jcb.200306134)
- Ashby, M. C., Camello-Almaraz, C., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2003. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. Journal of Biological Chemistry 278(23), pp. 20860-20864. (10.1074/jbc.M302599200)
- Gerasimenko, O. V., Maruyama, Y., Tepikin, A., Petersen, O. H. and Gerasimenko, J. V. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.
2002
- Yu, L. et al. 2002. An N-terminal truncated form of Orp150 Is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. Journal of Biological Chemistry 277(27), pp. 24538-24545. (10.1074/jbc.M203550200)
- Gerasimenko, J. V., Gerasimenko, O. V., Palejwala, A., Tepikin, A., Petersen, O. H. and Watson, A. J. M. 2002. Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. Journal of Cell Science 115, pp. 485-497.
- Gerasimenko, O. V., Gerasimenko, J. V., Rizzuto, R. R., Treiman, M., Tepikin, A. V. and Petersen, O. H. 2002. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32(5-6), pp. 261-268. (10.1016/S0143416002001938)
- Ashby, M. C., Craske, M., Park, M. K., Gerasimenko, O. V., Burgoyne, R. D., Petersen, O. H. and Tepikin, A. V. 2002. Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. Journal of cell biology 158(2), pp. 283-292.
2001
- Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2001. Membrane repair: Ca2+-elicited lysosomal exocytosis. Current Biology 11(23), pp. R971-R974. (10.1016/S0960-9822(01)00577-2)
2000
- Cansela, J. M., Gerasimenko, O. V., Gerasimenko, J. V., Tepikin, A. V. and Petersen, O. H. 2000. Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate. Embo Journal 19(11), pp. 2549-2557. (10.1093/emboj/19.11.2549)
Articles
- Gerasimenko, O. V. and Gerasimenko, J. V. 2024. The role of CFTR in diabetes‐induced pancreatic ductal dysfunction. The Journal of Physiology 602(6), pp. 993-994. (10.1113/jp286338)
- Lewis, S., Evans, D., Tsugorka, T., Peng, S., Stauderman, K., Gerasimenko, O. and Gerasimenko, J. 2024. Combination of the CRAC channel inhibitor CM4620 and galactose as a potential therapy for acute pancreatitis. Function 5(4), article number: zqae017. (10.1093/function/zqae017)
- Famili, D. T. et al. 2023. Pancreatitis in RYR1-related disorders. Neuromuscular Disorders 33(10), pp. 769-775. (10.1016/j.nmd.2023.09.003)
- Gerasimenko, J. V. and Gerasimenko, O. V. 2023. The role of Ca2+ signalling in the pathology of exocrine pancreas. Cell Calcium 112, article number: 102740. (10.1016/j.ceca.2023.102740)
- Gerasimenko, J. V. and Gerasimenko, O. V. 2023. Ca 2+ signaling and ATP production in pancreatic cancer. Function 5(1), article number: zqad067. (10.1093/function/zqad067)
- Kusiak, A. A. et al. 2022. Activation of pancreatic stellate cells attenuates intracellular Ca 2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites. Cell Death and Disease 13(8), article number: 744. (10.1038/s41419-022-05186-w)
- Gerasimenko, O. V. and Gerasimenko, J. V. 2022. CRAC channel inhibitors in pancreatic pathologies. Journal of Physiology 600(7), pp. 1597-1598. (10.1113/JP282826)
- Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2022. SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ. Function 3(2) (10.1093/function/zqac002)
- Petersen, O. H., Gerasimenko, J., Gerasimenko, O. V., Gryshchenko, O. and Peng, S. 2021. The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas. Physiological Reviews 101(4), pp. 1691-1744. (10.1152/physrev.00003.2021)
- Gryshchenko, O., Gerasimenko, J., Petersen, O. H. and Gerasimenko, O. V. 2020. Calcium signaling in pancreatic immune cells in situ. Function 2(1), article number: zqaa026. (10.1093/function/zqaa026)
- Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2020. Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+ and NAADP. Function 1(1), article number: zqaa003. (10.1093/function/zqaa003)
- Jakubowska, M. A. et al. 2019. ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells. British Journal of Pharmacology 176(22), pp. 4402-4415. (10.1111/bph.14505)
- Peng, S., Gerasimenko, J. V., Tsugorka, T. M., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2018. Galactose protects against cell damage in mouse models of acute pancreatitis. Journal of Clinical Investigation 128(9), pp. 3769-3778. (10.1172/JCI94714)
- Gryshchenko, O., Gerasimenko, J., Peng, S., Gerasimenko, O. V. and Petersen, O. H. 2018. Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. Journal of Physiology 596(14), pp. 2663-2678. (10.1113/JP275395)
- Vervliet, T., Gerasimenko, J. V., Ferdek, P. E., Jakubowska, M. A., Petersen, O. H., Gerasimenko, O. V. and Bultynck, G. 2018. BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis. Cell Death Discovery 4, article number: 58. (10.1038/s41420-018-0054-5)
- Gerasimenko, J. V., Peng, S., Tsugorka, T. and Gerasimenko, O. V. 2018. Ca 2+ signalling underlying pancreatitis. Cell Calcium 70, pp. 95-101. (10.1016/j.ceca.2017.05.010)
- Ferdek, P. E., Jakubowska, M. A., Polina, N., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2017. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death and Disease 8, article number: e2640. (10.1038/cddis.2017.41)
- Bittremieux, M. et al. 2017. DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store. Cell Calcium 62 (10.1016/j.ceca.2017.01.015)
- Ferdek, P. E., Jakubowska, M. A., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. Journal of Physiology 594(21), pp. 6147-6164. (10.1113/JP272774)
- Peng, S., Gerasimenko, J. V., Tsugorka, T., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2016. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 371(1700), article number: 20150423. (10.1098/rstb.2015.0423)
- Jakubowska, M. A., Ferdek, P. E., Gerasimenko, O. V., Gerasimenko, J. V. and Petersen, O. H. 2016. Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biology 6(8), article number: 160149. (10.1098/rsob.160149)
- Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Calcium signalling in pancreatic stellate cells: mechanisms and potential roles. Cell Calcium 59(2-3), pp. 140-144. (10.1016/j.ceca.2016.02.003)
- Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Ca2+ signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+ channel blockade. Journal of Physiology 594(2), pp. 281-293. (10.1113/JP271468)
- Gerasimenko, J. et al. 2015. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Cell Calcium 58(3), pp. 237-245. (10.1016/j.ceca.2015.05.005)
- Gerasimenko, J. V., Peng, S. and Gerasimenko, O. V. 2014. Role of acidic stores in secretory epithelia. Cell Calcium 55(6), pp. 346-354. (10.1016/j.ceca.2014.04.002)
- Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2014. Monitoring of intra-ER free Ca2+. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 3(3), pp. 63-71. (10.1002/wmts.106)
- Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2014. The role of Ca2+ in the pathophysiology of pancreatitis. The Journal of Physiology 592(2), pp. 269-280. (10.1113/jphysiol.2013.261784)
- Gerasimenko, J. V. et al. 2013. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110(32), pp. 13186-13191. (10.1073/pnas.1300910110)
- Ferdek, P., Gerasimenko, J. V., Peng, S., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2012. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Current Biology 22(13), pp. 1241-1246. (10.1016/j.cub.2012.05.002)
- Gerasimenko, O. V., Petersen, O. H. and Gerasimenko, J. V. 2012. Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation [Editorial]. Expert Review of Gastroenterology & Hepatology 6(2), pp. 129-131. (10.1586/EGH.12.5)
- Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2012. The war within - unraveling the molecular causes of acute pancreatitis - a potentially deadly disease in which the pancreas essentially digests itself - is yielding clues to how it might be treated. The Scientist 26(2), pp. 40-44.
- Gerasimenko, O. V. and Gerasimenko, J. V. 2012. Mitochondrial function and malfunction in the pathophysiology of pancreatitis. Pflugers Archiv European Journal of Physiology 464(1), pp. 89-99. (10.1007/s00424-012-1117-8)
- Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2011. Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports(3), article number: 15. (10.3410/M3-15)
- Petersen, O. H., Gerasimenko, O. V., Tepikin, A. and Gerasimenko, J. V. 2011. Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells. Cell Calcium 50(2), pp. 193-199. (10.1016/j.ceca.2011.02.010)
- Booth, D. et al. 2011. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140(7), pp. 2116-2125. (10.1053/j.gastro.2011.02.054)
- Gerasimenko, J. V. et al. 2011. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 108(14), pp. 5873-5878. (10.1073/pnas.1016534108)
- Voronina, S. G. et al. 2010. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5), pp. 1976-1987. (10.1053/j.gastro.2010.01.037)
- Lur, G. et al. 2009. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19(19), pp. 1648-1653. (10.1016/j.cub.2009.07.072)
- Baumgartner, H. K. et al. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. Journal of Biological Chemistry 284(31), pp. 20796-20803. (10.1074/jbc.M109.025353)
- Petersen, O. H., Tepikin, A. V., Gerasimenko, J. V., Gerasimenko, O. V., Sutton, R. and Criddle, D. N. 2009. Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis. Cell Calcium 45(6), pp. 634-642. (10.1016/j.ceca.2009.02.005)
- Gerasimenko, J. V. et al. 2009. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 106(26), pp. 10758-10763. (10.1073/pnas.0904818106)
- Fedirko, N., Gerasimenko, J. V., Tepikin, A. V. and Gerasimenko, O. V. 2009. Regulation of early response genes in pancreatic acinar cells: external calcium and nuclear calcium signalling aspects. Acta Physiologica 195(1), pp. 51-60. (10.1111/j.1748-1716.2008.01935.x)
- Barrow, S. L. et al. 2008. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Archiv - European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)
- Chvanov, M. et al. 2008. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Archiv-European Journal of Physiology 457(2), pp. 505-517. (10.1007/s00424-008-0529-y)
- Murphy, J. A. et al. 2008. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135(2), pp. 632-641. (10.1053/j.gastro.2008.05.026)
- Baumgartner, H. K. et al. 2007. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(1), pp. G296-G307. (10.1152/ajpgi.00103.2007)
- Voronina, S. G., Sherwood, M. W., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2007. Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(6), pp. G1333-G1338. (10.1152/ajpgi.00275.2007)
- Criddle, D. N. et al. 2007. Calcium signalling and pancreatic cell death: apoptosis or necrosis?. Cell Death and Differentiation 14(7), pp. 1285-1294. (10.1038/sj.cdd.4402150)
- Sherwood, M. W. et al. 2007. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 104(13), pp. 5674-5679. (10.1073/pnas.0700951104)
- Criddle, D. N. et al. 2006. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. Journal of Biological Chemistry 281(52), pp. 40485-40492. (10.1074/jbc.M607704200)
- Sherwood, M. W., Barrow, S. L., Dolman, N. J., Gerasimenko, O. V., Voronina, S. G. and Tepikin, A. V. 2006. Movement of calcium signals and calcium-binding proteins: firewalls, traps and tunnels. Biochemical Society Transactions 34(3), pp. 381-384. (10.1042/BST0340381)
- Gerasimenko, J. V., Flowerdew, S. E., Voronina, S. G., Sukhomlin, T. K., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2006. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. Journal of Biological Chemistry 281(52), pp. 40154-40163. (10.1074/jbc.M606402200)
- Chvanov, M., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2006. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO Journal 25(13), pp. 3024. (10.1038/sj.emboj.7601207)
- Gerasimenko, J. V., Sherwood, M., Tepikin, A., Petersen, O. H. and Gerasimenko, O. V. 2006. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. Journal of Cell Science 119(2), pp. 226-238. (10.1242/jcs.02721)
- Yu, L. G. et al. 2006. Galectin-3 interaction with Thomsen-Friedenreich Disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. Journal of Biological Chemistry 282(1), pp. 773-781. (10.1074/jbc.M606862200)
- Burdakov, D. et al. 2006. Tandem-Pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron -Cambridge Ma- 50(5), pp. 711-722. (10.1016/j.neuron.2006.04.032)
- Dolman, N. J., Gerasimenko, J. V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H. and Tepikin, A. V. 2005. Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. Journal of Biological Chemistry 280(16), pp. 15794-15799. (10.1074/jbc.M412694200)
- Voronina, S. G., Gryshchenko, O. V., Gerasimenko, O. V., Green, A. K., Petersen, O. H. and Tepikini, A. V. 2005. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. Journal of Biological Chemistry 280(3), pp. 1764-1770. (10.1074/jbc.M410230200)
- Burdakov, D., Gerasimenko, O. V. and Verkhratsky, A. 2005. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. Journal of Neuroscience 25(9), pp. 2429-2433. (10.1523/JNEUROSCI.4925-04.2005)
- Gerasimenko, O. V. and Tepikin, A. 2005. How to measure Ca2+ in cellular organelles?. Cell Calcium 38(3-4), pp. 201-211. (10.1016/j.ceca.2005.06.025)
- Watson, A. J. et al. 2005. Epithelial barrier function in vivo is sustained despite gaps in epithelial layers. Gastroenterology 129(3), pp. 902-912. (10.1053/j.gastro.2005.06.015)
- Voronina, S. G., Barrow, S. L., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2004. Effects of secretagogues and gile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating ΔΨm. Journal of Biological Chemistry 279(26), pp. 27327-27338. (10.1074/jbc.M311698200)
- Gerasimenko, O. V. and Gerasimenko, J. V. 2004. New aspects of nuclear calcium signalling. Journal of Cell Science 117(15), pp. 3087-3094. (10.1242/jcs.01295)
- Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2003. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Journal of Cell Biology 163(2), pp. 271-282. (10.1083/jcb.200306134)
- Ashby, M. C., Camello-Almaraz, C., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2003. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. Journal of Biological Chemistry 278(23), pp. 20860-20864. (10.1074/jbc.M302599200)
- Gerasimenko, O. V., Maruyama, Y., Tepikin, A., Petersen, O. H. and Gerasimenko, J. V. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.
- Yu, L. et al. 2002. An N-terminal truncated form of Orp150 Is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. Journal of Biological Chemistry 277(27), pp. 24538-24545. (10.1074/jbc.M203550200)
- Gerasimenko, J. V., Gerasimenko, O. V., Palejwala, A., Tepikin, A., Petersen, O. H. and Watson, A. J. M. 2002. Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. Journal of Cell Science 115, pp. 485-497.
- Gerasimenko, O. V., Gerasimenko, J. V., Rizzuto, R. R., Treiman, M., Tepikin, A. V. and Petersen, O. H. 2002. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32(5-6), pp. 261-268. (10.1016/S0143416002001938)
- Ashby, M. C., Craske, M., Park, M. K., Gerasimenko, O. V., Burgoyne, R. D., Petersen, O. H. and Tepikin, A. V. 2002. Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. Journal of cell biology 158(2), pp. 283-292.
- Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2001. Membrane repair: Ca2+-elicited lysosomal exocytosis. Current Biology 11(23), pp. R971-R974. (10.1016/S0960-9822(01)00577-2)
- Cansela, J. M., Gerasimenko, O. V., Gerasimenko, J. V., Tepikin, A. V. and Petersen, O. H. 2000. Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate. Embo Journal 19(11), pp. 2549-2557. (10.1093/emboj/19.11.2549)
Book sections
- Gerasimenko, O. V. and Gerasimenko, J. V. 2010. Two-photon permeabilization and calcium measurements in cellular organelles. In: Live Cell Imaging: Methods and Protocols., Vol. 591. Methods in Molecular Biology Vol. 2. Springer, pp. 201-210., (10.1007/978-1-60761-404-3_12)
Ymchwil
Prosiectau cyfredol:
- Ymchwilio i batholegau celloedd imiwnedd mewn pancreas exocrine gan ddefnyddio mewn paratoadau situ a microsgopeg dau ffoton.
- Astudiaethau patholegau sy'n arwain at sefydlu pancreatitis acíwt. Disgrifiwyd prif ddulliau a gyhoeddwyd yn ddiweddar yn Physiological Reviews (Petersen et al 2021; Gerasimenko & Gerasimenko 2023).
- Gwella triniaethau ar gyfer Plentyndod ALL.
Prosiectau'r gorffennol:
Rôl Rhyddhau Ca2+ a Ca2+ Mynediad yn Datblygu Pancreatitis Acíwt (David Evans et al heb ei gyhoeddi).
Ymchwilio i ffisioleg pancreas exocrine, gan ddefnyddio mewn paratoadau situ meinwe pancreatig a microsgopeg dau ffoton (Gryshchenko et al 2020 "Signalau calsiwm mewn celloedd imiwnedd pancreatig yn y fan a'r lle").
Ychwanegiadau ynni fel triniaeth bosibl ar gyfer pancreatitis acíwt (Shuang Peng et al 2018)
Mecanwaith pancreatitis a achosir gan asparaginase (Shuang Peng et al 2016)
Signalau calsiwm a achosir gan NAADP mewn celloedd acinar pancreatig (Gerasimenko et al 2015)
Atal mynediad calsiwm fel triniaeth bosibl ar gyfer pancreatitis acíwt (Gerasimenko et al 2013)
rheoleiddio Calmodulin mewn celloedd acinar pancreatig (Gerasimenko et al 2011)
Rôl Bcl-2 mewn signalau calsiwm mewn celloedd acinar pancreatig (Pawel Ferdek et al 2012)
Myfyrwyr Ymchwil Ôl-raddedig
- Mr Richard Charlesworth
- Dr Shuang Peng
- Miss Eloise Stapleton
- Mr David Evans
- Mr Aled Coughlan
Addysgu
Module Leader: BI3355 Advances in Physiology and Pathophysiology
Assessment Co-ordinator: BI3253 Advanced Cell Biology and Imaging.
Bywgraffiad
Darllenydd yn Ysgol y Biowyddorau, Prifysgol Caerdydd, y DU o 2010.
Darlithydd o 2000 ac yna Darllenydd o 2005 ym Mhrifysgol Lerpwl, y DU
Derbyniodd PhD gan Sefydliad Ffisioleg Bogomoletz Academi Gwyddoniaeth Wcrain ym 1991.
Cyhoeddwyd 103 o bapurau (9892 dyfyniadau gan Google Scholar, h-index 53).
Cymrawd y Gymdeithas Ffisiolegol, y Deyrnas Unedig.
Aelod o fwrdd golygyddol cyfnodolion: Scientific Reports, Cells and Pflügers Archiv - European Journal of Physiology.
Aelodaethau proffesiynol
Cymrawd Cymdeithas Ffisiolegol y Deyrnas Unedig
Meysydd goruchwyliaeth
Mae nifer o feysydd ymchwil ar gael ar gyfer prosiect posibl:
1. Ymchwilio i ffisioleg a phatholeg y pancreas exocrine, gan gynnwys ymchwiliadau yn y fan a'r lle gan ddefnyddio microsgopeg dau ffoton (Gryshchenko et al 2020 Signalau calsiwm mewn celloedd imiwnedd pancreatig yn y fan a'r lle).
2. Astudiaethau patholegau sy'n arwain at sefydlu pancreatitis acíwt. Cyhoeddwyd gwahanol ddulliau yn ddiweddar yn Physiological Reviews (Petersen et al 2021 Rolau calsiwm ac ATP yn ffisioleg a phatholeg y pancreas exocrine) ac mewn Calsiwm Cell (Gerasimenko a Gerasimenko 2023 Rôl signalau Ca2 + ym mhatholeg pancreas exocrine).
3. Rôl llid mewn pancreatitis acíwt (signalau Gryshchenko et al Calsiwm mewn celloedd imiwnedd pancreatig yn y fan a'r lle. Gerasimenko et al 2022, is-uned protein SARS-CoV-2 S 1 Elicits Ca2+ mewnlifiad - Arwyddion Ca2 + Dibynnol mewn celloedd Stellate Pancreatig a Macrophages Yn Situ).
4. Gwella triniaethau therapiwtig ar gyfer POB Plentyndod. (Peng et al 2016, Calsiwm ac adenosine triphosphate rheolaeth o batholeg gellog: pancreatitis a achosir gan asbaraginase a achosir trwy dderbynnydd activated protease-2, Peng et al 2018 Galactose amddiffyn rhag difrod celloedd mewn modelau llygoden o pancreatitis acíwt).
Contact Details
+44 29208 70864
Adeilad Syr Martin Evans, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX