![Sophie Gilbert BSc (Hons), PhD](https://profiles-cardiff.imgix.net/attachments/1027?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Sophie Gilbert
BSc (Hons), PhD
Cydymaith Ymchwil Ôl-ddoethurol
Ysgol y Biowyddorau
Trosolwyg
My research interests encompass three areas of cartilage biology: the role of inflammatory cytokine signalling and mechanical load in cartilage degeneration and cartilage repair strategies. My current research involves delineating the role of PKR in arthritis in order to reveal new mechanisms of cytokine and mechanical load mediated cartilage degradation that may be targeted in treatment or diagnosis of arthritis. Another research priority focuses on cartilage repair with particular emphasis on investigating why repair tissue poorly integrates with the surrounding host cartilage.
Cyhoeddiad
2024
- Jones, R., Gilbert, S. J., Christofides, S. R. and Mason, D. J. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15, article number: 1480274. (10.3389/fendo.2024.1480274)
- Gilbert, S. J. et al. 2024. Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models. Disease Models & Mechanisms 17(10), article number: dmm050583. (10.1242/dmm.050583)
- Kalsoum, R. et al. 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13(9), pp. 513-524. (10.1302/2046-3758.139.BJR-2024-0109)
- Gilbert, S. J., Jones, R., Egan, B. J., Bonnet, C. S., Evans, S. L. and Mason, D. J. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15, article number: 1359052. (10.3389/fendo.2024.1359052)
2022
- Gilbert, S. J., Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32, article number: 101323. (10.1016/j.bbrep.2022.101323)
2021
- Gilbert, S. J., Bonnet, C. S. and Blain, E. J. 2021. Mechanical cues: bidirectional reciprocity in the extracellular matrix drives mechano-signalling in articular cartilage. International Journal of Molecular Sciences 22(24), article number: 13595. (10.3390/ijms222413595)
- Tobias, J. H. et al. 2021. Opportunities and challenges in functional genomics research in osteoporosis: report from a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in Endocrinology 11, article number: 630875. (10.3389/fendo.2020.630875)
- Stadnik, P. S. et al. 2021. Regulation of microRNA‐221, ‐222, ‐21 and ‐27 in articular cartilage subjected to abnormal compressive forces. Journal of Physiology 599(1), pp. 143-155., article number: V. (10.1113/JP279810)
2020
- Bonnet, C. S., Gilbert, S. J., Blain, E. J., Williams, A. S. and Mason, D. J. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5(13), article number: e134055. (10.1172/jci.insight.134055)
2018
- Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
- Gilbert, S. and Blain, E. 2018. Cartilage mechanobiology: how chondrocytes respond to mechanical load. In: Verbruggen, S. ed. Mechanobiology in Health and Disease. London UK: Elsevier, pp. 99-126.
2016
- Al-Sabah, A., Stadnik, P., Gilbert, S., Duance, V. and Blain, E. 2016. Importance of reference gene selection for articular cartilage mechanobiology studies. Osteoarthritis and Cartilage 24(4), pp. 719-730. (10.1016/j.joca.2015.11.007)
2014
- Bonnet, C. S., Williams, A. S., Gilbert, S. J., Harvey, A. K., Evans, B. A. and Mason, D. J. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74, pp. 242-251. (10.1136/annrheumdis-2013-203670)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
- Bonnet, C., Williams, A. S., Gilbert, S. J., Harvey, A., Evans, B. A. J. and Mason, D. J. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95(3), pp. A5-A6. (10.1111/iep.12078)
- Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)
2012
- Bonnet, C., Williams, A. S., Harvey, A., Gilbert, S. J., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23, pp. S527-S527.
- Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.
2011
- Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Khan, I. M. et al. 2011. Interleukin-1β enhances cartilage-to-cartilage integration. European Cells and Materials 22, pp. 190-201.
- Parsons, P. et al. 2011. Identification of a type IX collagen interaction with fibronectin: a molecular bridge in articular cartilage?. The Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
2010
- Gilbert, S. J., Patel, M., Toumi, H., Duance, V. C. and Mason, D. J. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91(2), pp. A34-A34. (10.1111/j.1365-2613.2009.00690.x)
2009
- Singhrao, S., Müller, C. T., Gilbert, S. J., Duance, V. C. and Archer, C. W. 2009. An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New(R) using fluorescein isothiocyanate secondary detection. Microscopy Research and Technique 72(7), pp. 501-506. (10.1002/jemt.20705)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112. (10.1111/j.1365-2613.2008.00644.x)
- Singhrao, S. K., Müller, C. T., Gilbert, S. J., Duance, V. C. and Archer, C. W. 2009. An immunofluorescence method for post-embedded tissue in acrylic resin Technovit 9100 New(R) using fluorescein isothiocyanate secondary detection marker [Abstract]. International Journal of Experimental Pathology 90(2), pp. A129.
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112.
- Gilbert, S. J. et al. 2009. Enhanced Tissue Integration During Cartilage Repair In Vitro Can Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge. Tissue Engineering :Part A 15(7), pp. 1739-1749. (10.1089/ten.tea.2008.0361)
- Khan, I. M., Bishop, J. C., Gilbert, S. J. and Archer, C. W. 2009. Clonal chondroprogenitors maintain telomerase activity and Sox9 expression during extended monolayer culture and retain chondrogenic potential. Osteoarthritis and Cartilage 17(4), pp. 518-528. (10.1016/j.joca.2008.08.002)
2008
- Gilbert, S. J., Singhrao, S. K., Khan, I., Duance, V. C. and Archer, C. 2008. Inhibition of chondrocyte death at the wound edge enhances integrative cartilage repair. European Cells and Materials 16, pp. 26-39.
- Khan, I. M., Gilbert, S. J., Caterson, B., Sandell, L. and Archer, C. W. 2008. Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage. Osteoarthritis and Cartilage 16(6), pp. 698-707. (10.1016/j.joca.2007.10.004)
- Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
- Gilbert, S. J., Singhrao, S. K., Khan, I. M., Duance, V. C. and Archer, C. W. 2008. Inhibiting chondrocyte death at the wound edge results in successful integrative cartilage repair in vitro. European Cells and Materials 16(Supp 3), pp. 55-55.
- Davies, L. C., Blain, E., Gilbert, S. J., Caterson, B. and Duance, V. 2008. The potential of IGF-1 and TGFβ1 for promoting “adult” articular cartilage repair: An in vitro study. Tissue Engineering Part A 14(7), pp. 1251-1261. (10.1089/ten.tea.2007.0211)
- Khan, I. M., Gilbert, S. J., Singhrao, S., Duance, V. C. and Archer, C. W. 2008. Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. (A review). European Cells & Materials 16, pp. 26-39.
2006
- Blain, E. J., Gilbert, S. J., Hayes, A. J. and Duance, V. C. 2006. Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis.. Matrix biology 25(7), pp. 398-408. (10.1016/j.matbio.2006.06.002)
- Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1), pp. 9-21. (10.2174/157339706775697026)
2005
- Blain, E. J., Gilbert, S. J. and Duance, V. C. 2005. An intact cytoskeleton is essential to maintain articular cartilage chondrocyte metabolism. International Journal of Experimental Pathology 86(3), pp. A10-A11. (10.1111/j.0959-9673.2005.00426.x)
2003
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6(1), pp. R46-R55. (10.1186/ar1024)
2002
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30(6), pp. 886-889. (10.1042/BST0300886)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30, pp. 886-889. (10.1042/bst0300886)
2001
- Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)
2000
- Vaughan-Thomas, A., Gilbert, S. J. and Duance, V. 2000. Elevated levels of proteolytic enzymes in the aging human vitreous. Investigative Ophthalmology & Visual Science 41(11), pp. 3299-32304.
- Gilbert, S. J., Wotton, P. R., Bailey, A. J., Sims, T. J. and Duance, V. C. 2000. Alterations in the organisation, ultrastructure and biochemistry of the myocardial collagen matrix in Doberman pinschers with dilated cardiomyopathy. Research in Veterinary Science 69(3), pp. 267-274. (10.1053/rvsc.2000.0423)
1997
- Gilbert, S. J., Wotton, P. R., Tarlton, J. F., Duance, V. C. and Bailey, A. J. 1997. Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy. Cardiovascular Research 34(2), pp. 377-383. (10.1016/S0008-6363(97)00011-4)
Articles
- Jones, R., Gilbert, S. J., Christofides, S. R. and Mason, D. J. 2024. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Frontiers in Endocrinology 15, article number: 1480274. (10.3389/fendo.2024.1480274)
- Gilbert, S. J. et al. 2024. Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models. Disease Models & Mechanisms 17(10), article number: dmm050583. (10.1242/dmm.050583)
- Kalsoum, R. et al. 2024. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.. Bone & Joint Research 13(9), pp. 513-524. (10.1302/2046-3758.139.BJR-2024-0109)
- Gilbert, S. J., Jones, R., Egan, B. J., Bonnet, C. S., Evans, S. L. and Mason, D. J. 2024. Investigating mechanical and inflammatory pathological mechanisms in osteoarthritis using MSC-derived osteocyte-like cells in 3D. Frontiers in Endocrinology 15, article number: 1359052. (10.3389/fendo.2024.1359052)
- Gilbert, S. J., Blain, E. J. and Mason, D. J. 2022. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms. Biochemistry and Biophysics Reports 32, article number: 101323. (10.1016/j.bbrep.2022.101323)
- Gilbert, S. J., Bonnet, C. S. and Blain, E. J. 2021. Mechanical cues: bidirectional reciprocity in the extracellular matrix drives mechano-signalling in articular cartilage. International Journal of Molecular Sciences 22(24), article number: 13595. (10.3390/ijms222413595)
- Tobias, J. H. et al. 2021. Opportunities and challenges in functional genomics research in osteoporosis: report from a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in Endocrinology 11, article number: 630875. (10.3389/fendo.2020.630875)
- Stadnik, P. S. et al. 2021. Regulation of microRNA‐221, ‐222, ‐21 and ‐27 in articular cartilage subjected to abnormal compressive forces. Journal of Physiology 599(1), pp. 143-155., article number: V. (10.1113/JP279810)
- Bonnet, C. S., Gilbert, S. J., Blain, E. J., Williams, A. S. and Mason, D. J. 2020. AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. JCI Insight 5(13), article number: e134055. (10.1172/jci.insight.134055)
- Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
- Al-Sabah, A., Stadnik, P., Gilbert, S., Duance, V. and Blain, E. 2016. Importance of reference gene selection for articular cartilage mechanobiology studies. Osteoarthritis and Cartilage 24(4), pp. 719-730. (10.1016/j.joca.2015.11.007)
- Bonnet, C. S., Williams, A. S., Gilbert, S. J., Harvey, A. K., Evans, B. A. and Mason, D. J. 2014. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of the Rheumatic Diseases 74, pp. 242-251. (10.1136/annrheumdis-2013-203670)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
- Bonnet, C., Williams, A. S., Gilbert, S. J., Harvey, A., Evans, B. A. J. and Mason, D. J. 2014. NBQX, a glutamate receptor antagonist, alleviates inflammation, pathology and gait abnormalities in a rat model of inflammatory arthritis. International Journal of Experimental Pathology 95(3), pp. A5-A6. (10.1111/iep.12078)
- Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)
- Bonnet, C., Williams, A. S., Harvey, A., Gilbert, S. J., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23, pp. S527-S527.
- Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.
- Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Khan, I. M. et al. 2011. Interleukin-1β enhances cartilage-to-cartilage integration. European Cells and Materials 22, pp. 190-201.
- Parsons, P. et al. 2011. Identification of a type IX collagen interaction with fibronectin: a molecular bridge in articular cartilage?. The Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
- Gilbert, S. J., Patel, M., Toumi, H., Duance, V. C. and Mason, D. J. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91(2), pp. A34-A34. (10.1111/j.1365-2613.2009.00690.x)
- Singhrao, S., Müller, C. T., Gilbert, S. J., Duance, V. C. and Archer, C. W. 2009. An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New(R) using fluorescein isothiocyanate secondary detection. Microscopy Research and Technique 72(7), pp. 501-506. (10.1002/jemt.20705)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112. (10.1111/j.1365-2613.2008.00644.x)
- Singhrao, S. K., Müller, C. T., Gilbert, S. J., Duance, V. C. and Archer, C. W. 2009. An immunofluorescence method for post-embedded tissue in acrylic resin Technovit 9100 New(R) using fluorescein isothiocyanate secondary detection marker [Abstract]. International Journal of Experimental Pathology 90(2), pp. A129.
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112.
- Gilbert, S. J. et al. 2009. Enhanced Tissue Integration During Cartilage Repair In Vitro Can Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge. Tissue Engineering :Part A 15(7), pp. 1739-1749. (10.1089/ten.tea.2008.0361)
- Khan, I. M., Bishop, J. C., Gilbert, S. J. and Archer, C. W. 2009. Clonal chondroprogenitors maintain telomerase activity and Sox9 expression during extended monolayer culture and retain chondrogenic potential. Osteoarthritis and Cartilage 17(4), pp. 518-528. (10.1016/j.joca.2008.08.002)
- Gilbert, S. J., Singhrao, S. K., Khan, I., Duance, V. C. and Archer, C. 2008. Inhibition of chondrocyte death at the wound edge enhances integrative cartilage repair. European Cells and Materials 16, pp. 26-39.
- Khan, I. M., Gilbert, S. J., Caterson, B., Sandell, L. and Archer, C. W. 2008. Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(-) in adult bovine articular cartilage. Osteoarthritis and Cartilage 16(6), pp. 698-707. (10.1016/j.joca.2007.10.004)
- Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
- Gilbert, S. J., Singhrao, S. K., Khan, I. M., Duance, V. C. and Archer, C. W. 2008. Inhibiting chondrocyte death at the wound edge results in successful integrative cartilage repair in vitro. European Cells and Materials 16(Supp 3), pp. 55-55.
- Davies, L. C., Blain, E., Gilbert, S. J., Caterson, B. and Duance, V. 2008. The potential of IGF-1 and TGFβ1 for promoting “adult” articular cartilage repair: An in vitro study. Tissue Engineering Part A 14(7), pp. 1251-1261. (10.1089/ten.tea.2007.0211)
- Khan, I. M., Gilbert, S. J., Singhrao, S., Duance, V. C. and Archer, C. W. 2008. Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. (A review). European Cells & Materials 16, pp. 26-39.
- Blain, E. J., Gilbert, S. J., Hayes, A. J. and Duance, V. C. 2006. Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis.. Matrix biology 25(7), pp. 398-408. (10.1016/j.matbio.2006.06.002)
- Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1), pp. 9-21. (10.2174/157339706775697026)
- Blain, E. J., Gilbert, S. J. and Duance, V. C. 2005. An intact cytoskeleton is essential to maintain articular cartilage chondrocyte metabolism. International Journal of Experimental Pathology 86(3), pp. A10-A11. (10.1111/j.0959-9673.2005.00426.x)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6(1), pp. R46-R55. (10.1186/ar1024)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30(6), pp. 886-889. (10.1042/BST0300886)
- Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30, pp. 886-889. (10.1042/bst0300886)
- Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)
- Vaughan-Thomas, A., Gilbert, S. J. and Duance, V. 2000. Elevated levels of proteolytic enzymes in the aging human vitreous. Investigative Ophthalmology & Visual Science 41(11), pp. 3299-32304.
- Gilbert, S. J., Wotton, P. R., Bailey, A. J., Sims, T. J. and Duance, V. C. 2000. Alterations in the organisation, ultrastructure and biochemistry of the myocardial collagen matrix in Doberman pinschers with dilated cardiomyopathy. Research in Veterinary Science 69(3), pp. 267-274. (10.1053/rvsc.2000.0423)
- Gilbert, S. J., Wotton, P. R., Tarlton, J. F., Duance, V. C. and Bailey, A. J. 1997. Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy. Cardiovascular Research 34(2), pp. 377-383. (10.1016/S0008-6363(97)00011-4)
Book sections
- Gilbert, S. and Blain, E. 2018. Cartilage mechanobiology: how chondrocytes respond to mechanical load. In: Verbruggen, S. ed. Mechanobiology in Health and Disease. London UK: Elsevier, pp. 99-126.
Ymchwil
Mae fy niddordebau ymchwil yn cwmpasu tri maes o gartilag a bioleg esgyrn, rolau signalau cytokin llidiol a llwyth mecanyddol mewn strategaethau adfywio a thrwsio cartilag ar y cyd.
Mawrth 2023 - NC3Rs cyfredol: Profi a dilysu model chondrocyte dynol in vitro 3D i gymryd lle defnydd anifeiliaid mewn ymchwil mehanobioleg.
Awst 2021 - Mawrth 2023 Orphelian / Versus Arthritis: Gwnaethom ddefnyddio atalydd mGluR5 i sefydlu rôl y llwybr signalau glwtamad yn ymateb yr osteocytes i lid neu lwyth yn ein model osteocyte 3D in vitro ac yn vivo model PTOA a phenderfynu effaith llawdriniaeth HTO ar reoleiddio genynnau sy'n ymwneud ag ailfodelu esgyrn.
Jul 2018 - Mawrth 2022 Ymddiriedolaeth Wellcome: Defnyddiais RNAseq i ymchwilio i'r 'mecanosom' mewn osteocytes bôn-gelloedd dynol. Yn ogystal, bûm yn cydweithio â Dr Blain (BIOSI) i ymchwilio i reoleiddio epigenetig a achosir gan lwyth mewn homeostasis cartilag.
Ionawr 2017 - Gorff 2018 NC3Rs: Nod y prosiect hwn oedd gwahaniaethu bôn-gelloedd dynol i gelloedd esgyrn a chartilag, er mwyn ymchwilio iddynt o dan lwyth mecanyddol mewn modelau 3D ar gyfer sgrinio cyffuriau. Ariannwyd y bartneriaeth ddiwydiannol hon gyda Kirkstall a Biogelx gan her TG CRACK, prosiect NC3Rs sy'n ariannu cydweithrediad rhwng diwydiant, academyddion a busnesau bach a chanolig i leihau'r angen am anifeiliaid mewn ymchwil.
Ionawr 2010 – Rhag 2018 Versus Arthritis/Prifysgol Caerdydd Seedcorn: Ymchwiliais i rôl y moleciwl signalu, Protein Kinase R (PKR), prif reolydd prosesau celloedd sylfaenol, ym mecanweithiau clefydau esgyrn a chartilag. Datgelodd y gwaith hwn rôl allweddol ar gyfer PKR mewn ymatebion cartilag i lid a llwyth, ac yn fwy diweddar mewn gwahaniaethu osteobig ac ailfodelu esgyrn a achosir gan cytokine. Mae fy astudiaethau wedi darparu mewnwelediadau pwysig i'r mecanweithiau moleciwlaidd a allai yrru dirywiad ar y cyd. Cawsom wobr 2018 am "Ragoriaeth mewn Gwyddoniaeth Sylfaenol, Clinigol, a Chyfieithul" a roddwyd gan y Journal of Orthopaedic Research am y cyhoeddiad Gilbert SJ, Bonnet CS, Stadnik PS, Duance VC, Mason DJ, Blain EJ (2018). Cyfnodau llidiol a dirywiol sy'n deillio o rupture croeshoelio anterior mewn model murin anfewnwthiol o osteoarthritis ôl-drawmatig. Journal of Ymchwil Orthopedig 36 (8), tt. 2118-2127.
2007 – 2010 DTI/Smith & Nai: Darganfu'r ymchwil hon rwystrau i integreiddio cartilag-cartilag a datblygu damcaniaethau ar gyfer integreiddio cartilag yn well. Roedd y prosiect yn gofyn am adroddiadau cynnydd technegol llawn yn ogystal â lledaenu canlyniadau ar lafar i bartneriaid diwydiannol trwy gyfarfodydd wyneb yn wyneb a skype.
1997 – 2007 Ymgyrch Ymchwil Elusen/Arthritis Henry Smith: Adnabod a nodweddu llwybr signalau PKR mewn dirywiad ar y cyd.
. Dyfarniadau
• Enillydd gwobr poster 1af; Cynhadledd Flynyddol Cymdeithas Meinweoedd a Pheirianneg Cell 2008
• Gwobr 2018 am "Rhagoriaeth mewn Gwyddoniaeth Sylfaenol, Clinigol, a Chyfieithul" a gyflwynwyd gan y Journal of Orthopaedic Research ar gyfer y cyhoeddiad Gilbert SJ, Bonnet CS, Stadnik PS, Duance VC, Mason DJ, Blain EJ (2018). Cyfnodau llidiol a dirywiol sy'n deillio o rupture croeshoelio anterior mewn model murin anfewnwthiol o osteoarthritis ôl-drawmatig. Journal of Ymchwil Orthopedig 36 (8), tt. 2118-2127
Dyfarnu grantiau
· S.J. Gilbert (£2072) Ymchwilio i rôl y sianel ïonau mecanosensitif, Piezo1 wrth ailfodelu esgyrn. Cronfa Seedcorn y Brifysgol, 2023
S.J. Gilbert (£1327.34) Cronfa ŷd hadau prifysgol, Mai 2018
Deborah Mason (PI), Paul Genever (Efrog), Bronwen Evans, Emma Blain, Sophie Gilbert, Cleo Bonnet, Daniel Aeschlimann, Sam Evans, Cathy Holt a phartneriaid diwydiannol (Kelly Davidge, Kirkstall; Laura Goldie, Biogelx) (£99,820) NC3Rs Crack-IT Her, OsteoChip, Jan-Jun 2017
Dr EJ Blain, Dr SJ Gilbert, Dr AJ Hayes (£90,000) I Arthritis Research UK Biomechanics and Bioengineering Centre PhD efrydiaeth PhD 2017-2021
S.J. Gilbert (£2500) Grant Cyfarfod Gwyddonol Cwmni Biolegwyr 2016
S.J. Gilbert (£500) Grant Cyfarfodydd Bach y Gymdeithas Biocemegol 2016
S.J Gilbert (£530) Bwrsariaeth teithio CITER 2016
SJ Gilbert (£2000) Grant Cyfarfod Gwyddonol Cwmni Biolegwyr 2015
SJ Gilbert (£1440) Lleoliad haf myfyrwyr israddedig CITER 2015
SJ Gilbert (£1440) Lleoliad haf CUROP 2015
Dr DJ Mason, Dr SJ Gilbert a'r Athro VC Duance (£81227) Ymgyrch Ymchwil Arthritis 2004 – 2006
Dr DJ Mason, Dr SJ Gilbert a'r Athro VC Duance (£92149) Ymgyrch Ymchwil Arthritis 2002 – 2004
Dr DJ Mason, Dr SJ Gilbert a'r Athro VC Duance (£46266) Elusen Henry Smith 2000 - 2001
Cydweithredwyr
Allanol
- Yr Athro Ladiges a Dr John Morton (Meddygaeth Gymharol Dept, Prifysgol Washington) – P58IPK astudiaethau knockout
- Yr Athro J Tobias a'r Athro C Gregson (Prifysgol Bryste)
- Dr Chrissy Hammond (Prifysgol Bryste)
- Yr Athro F. Guilak (Prifysgol Washington)
Mewnol
- Dr D J Mason, Dr EJ Blain (Ysgol y Biowyddorau)
Addysgu
Is-raddedig
• Rwy'n cyfrannu at addysgu ar lwyth mecanyddol a bioleg cyhyrysgerbydol (BI3321: anatomeg swyddogaethol y System Cyhyrysgerbydol)
• Rwy'n helpu i ddarparu sesiynau ymarferol yn y labordy (BI2332: Cysyniadau Clefydau) a gweithdai (BI3351 Pynciau Cyfoes mewn Clefyd) ac yn goruchwylio, ac asesu prosiectau labordy BSc blwyddyn olaf (BI3001)
Lefel ôl-raddedig:
• Rwy'n cyfrannu at gwrs MSc Sefydliad Peirianneg a Thrwsio Meinwe (CITER) Caerdydd (DET002 a BIT001).
• Rwy'n goruchwylio, goruchwylio ac asesu prosiectau labordy MSc Peirianneg Meinwe, IAESTE, a Meistr Integredig (BI4001)
Bywgraffiad
Gwnes fy ngradd israddedig ym Mhrifysgol Newcastle ac yna cwblheais PhD ym 1997 ym Mhrifysgol Bryste gan ymchwilio i rôl colagen ym pathogenesis cardiomyopathi ymledol. Symudais i Labordai Bioleg Ymchwil Meinweoedd Cysylltiol yn Ysgol y Biowyddorau, Caerdydd yn 1997.
Aelodaethau proffesiynol
- Aelod o'r Gymdeithas Ymchwil Orthopedig 2018-gyfredol
- Aelod o bwyllgor Cymdeithas Bioleg Matrics Prydain a BSMB 2014-2017
- Cyd-drefnydd (gyda Dr Emma Blain) o gyfarfod yr Hydref BSMB (130 o gynrychiolwyr cenedlaethol a rhyngwladol) – Caerdydd Medi 2013
- Trefnydd cyfarfod Hydref BSMB 2016, Caerdydd;
- Aelod o Bwyllgor Ymchwil Sefydliad Peirianneg a Thrwsio a CITER y Sefydliad Meinwe Caerdydd 2012-2017, Cadeirydd Pwyllgor Ymgysylltu CITER 2016-2019
- Trefnydd gweithdy CITER Imaging (Ionawr 2017)
- Trefnydd gweithdy Signalau Cell CITER (Ebrill 2014)
- Aelod o'r Gymdeithas Peirianneg Meinweoedd a Chelloedd (TCES).
- Aelod o Ganolfan Biomecaneg a Biobeirianneg Ymchwil Arthritis y DU a Phwyllgor PPI ac Ymgysylltu, 2016-
Pwyllgorau ac adolygu
- Golygydd Cyswllt: Bone and Joint Research Joint - cyfredol
- Golygydd Adolygiad ar gyfer Frontiers in Medicine
- Pwyllgor Ymgysylltu - Sefydliad Dysgu Peirianneg a Thrwsio Meinwe Caerdydd
- Pwyllgor Ymchwil - Sefydliad Dysgu Peirianneg a Thrwsio Meinwe Caerdydd
Ymgysylltu
ArrayContact Details
GilbertSJ1@caerdydd.ac.uk
+44 29208 74287
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
+44 29208 74287
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Themâu ymchwil
Arbenigeddau
- Cell anifeiliaid a bioleg foleciwlaidd
- Biomecaneg
- Bioleg Celloedd
