Yr Athro Mark Good
BSc, DPhil

Cadair

Crynodeb ymchwil

Mae'r llabed amserol canolrif ac yn enwedig yr hippocampus wedi bod yn gysylltiedig ers amser maith â swyddogaeth cof mewn bodau dynol ac anifeiliaid nad ydynt yn ddynol. Mae'r rhanbarth hwn yn aml yn ymwneud â chyflyrau seiciatrig a niwroddirywiol, fel sgitsoffrenia a chlefyd Alzheimer. Nod fy ymchwil presennol yw mynd i'r afael â dau brif gwestiwn:

Pa rôl mae'r hippocampus a strwythurau ymennydd cysylltiedig yn ei chwarae yn y cof?
Sut mae cyflyrau niwroddirywiol yn dylanwadu ar swyddogaeth yr hippocampus?

Wrth fynd i'r afael â'r cwestiynau hyn, rwy'n defnyddio modelau preclinical o synaptig patholeg yr ymennydd gan gynnwys modelau genetig o gyflyrau niwroddirywiol etifeddadwy, fel clefyd Alzheimer a dementia frontotemporal.

Mae'r prosiectau presennol yn cynnwys:

asesu swbstradau seicolegol a niwral cof tebyg i gonfensiwn ac episodig, nodweddu modelau trawsgenig clefyd Alzheimer;
ymchwilio i fanteision seicolegol a niwral atchwanegiadau dietegol ar batholeg Alzheimer;
asesiad o driniaeth gwrthgyrff newydd ar gyfer patholeg amyloid;
Ymchwilio i dderbynyddion cannabinoid yn y cof a chlefydau niwroddirywiol;
Rôl priming mamol ar ddechrau clefyd Alzheimer yn ddiweddarach mewn bywyd.

Crynodeb addysgu

Mae fy addysgu yn cynnwys: darlithoedd ar seicoleg fiolegol i fyfyrwyr israddedig lefel 2; modiwl lefel 3 cyflawn ar niwrowyddoniaeth dysgu a chof; Darlithoedd i fyfyrwyr niwrowyddoniaeth a myfyrwyr meddygol ar fodelau cyn-glinigol clefyd Alzheimer a swyddogaeth cortigol uwch mewn pobl, yn y drefn honno.

Date
Type

2023

Boxall, F. A. and Good, M. A. 2023. The AppNLGF mouse model of amyloid pathology: Age-related behavioural characterisation. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 19(S24), article number: e082604. (10.1002/alz.082604)
Roberts, L. D. et al. 2023. The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice. EMBO Reports 24(12), article number: e57269. (10.15252/embr.202357269)
Neuparth-Sottomayor, M. et al. 2023. Cognitive comorbidities of experimental absence seizures are independent of anxiety. Neurobiology of Disease 186, article number: 106275. (10.1016/j.nbd.2023.106275)
Webberley, T. S. et al. 2023. Assessment of Lab4P probiotic effects on cognition in 3xTg-AD Alzheimer’s disease model mice and the SH-SY5Y neuronal cell line. International Journal of Molecular Sciences 24(5), article number: 4683. (10.3390/ijms24054683)
Muza, P. M. et al. 2023. Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture. iScience 26(2), pp. 1-22., article number: 106073. (10.1016/j.isci.2023.106073)
MacLachlan, R., Evans, C. E., Chai, S. Y., Good, M. A., Kehoe, P. G. and Miners, J. S. 2023. Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer?s disease pathology in mouse models of Alzheimer?s disease. Aging Brain 3, article number: 100062. (10.1016/j.nbas.2022.100062)

2022

Sedgwick, K. S., Dwyer, D., Good, M. A. and Saito, T. 2022. The role of the Locus Coeruleus in depression in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 18(S7), article number: e062257. (10.1002/alz.062257)

2021

Lana-Elola, E. et al. 2021. Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes. Disease Models and Mechanisms 14(10), article number: 49157. (10.1242/dmm.049157)
D'Souza, H., Brady, D., Wiseman, F. K., Good, M. A. and Thomas, M. S. C. 2021. Aligning cognitive studies in mouse models and human infants/toddlers: the case of Down Syndrome. In: Thomas, M. S. C., Mareschal, D. and Knowland, V. eds. Taking Development Seriously A Festschrift for Annette Karmiloff-Smith: Neuroconstructivism and the multi-disciplinary approach to understanding the emergence of mind. Taylor and Francis, pp. 213-238.

2020

Bevan, R. J., Hughes, T. R., Williams, P. A., Good, M. A., Morgan, B. P. and Morgan, J. E. 2020. Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease. Acta Neuropathologica Communications 8(1), article number: 216. (10.1186/s40478-020-01094-2)
Bevan, R. J. et al. 2020. OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory. Brain Communications 2(2), article number: fcaa101. (10.1093/braincomms/fcaa101)
Evans, C. E. et al. 2020. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease. Acta Neuropathologica 139, pp. 485-502. (10.1007/s00401-019-02098-6)
Michael, D. R. et al. 2020. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Scientific Reports 10(1), pp. -., article number: 4183. (10.1038/s41598-020-60991-7)
Chang, P. et al. 2020. Altered hippocampal-prefrontal neural dynamics in mouse models of Down syndrome. Cell Reports 30(4), pp. 1152-1163.e4. (10.1016/j.celrep.2019.12.065)

2019

Evans, C. E., Thomas, R. S., Freeman, T. J., Hvoslef-Eide, M., Good, M. A. and Kidd, E. J. 2019. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiology of Aging 75, pp. 136-149. (10.1016/j.neurobiolaging.2018.11.011)
Michael, D., Davies, T., Loxley, K., Allen, M., Good, M., Hughes, T. and Plummer, S. 2019. In vitro neuroprotective activities of two distinct probiotic consortia. Beneficial Microbes 10(4), pp. 437-447. (10.3920/BM2018.0105)

2018

Baruchin, L. J., Ranson, A., Good, M. and Crunelli, V. 2018. Absence of neuronal response modulation with familiarity in perirhinal cortex. Neuroscience 394, pp. 23-29. (10.1016/j.neuroscience.2018.10.020)
Evans, C., Hvoslefeide, M., Thomas, R., Kidd, E. and Good, M. 2018. A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology. Neurobiology of Learning and Memory 149, pp. 46-57. (10.1016/j.nlm.2018.02.004)

2017

O'Hagan, C., Li, J. V., Marchesi, J. R., Plummer, S., Garaiova, I. and Good, M. A. 2017. Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats. Neurobiology of Learning and Memory 144, pp. 36-47. (10.1016/j.nlm.2017.05.015)
Thomas, R., Alsaqati, M., Bice, J., Hvoslef-Eide, M., Good, M. and Kidd, E. 2017. Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology - implications for Alzheimer's disease. NeuroReport 28(15), pp. 963-968. (10.1097/WNR.0000000000000861)
Dumigan, N. M., Lin, T., Good, M. A. and Honey, R. C. 2017. Conditioning with spatio-temporal patterns: Constraining the contribution of the hippocampus to configural learning. Neurobiology of Learning and Memory 142(B), pp. 244-251. (10.1016/j.nlm.2017.05.004)

2016

Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
Lin, T. E., Dumigan, N. M., Good, M. and Honey, R. C. 2016. Novel sensory preconditioning procedures identify a specific role for the hippocampus in pattern completion. Neurobiology of Learning and Memory 130, pp. 142-148. (10.1016/j.nlm.2016.02.006)
Hall, J. H., Wiseman, F. K., Fisher, E. M. C., Tybulewicz, V. L. J., Harwood, J. L. and Good, M. A. 2016. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory 130, pp. 118-128. (10.1016/j.nlm.2016.02.002)

2010

Sanderson, D. J., McHugh, S. B., Good, M. A., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P. and Bannerman, D. M. 2010. Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner's dual-process memory model. Neuropsychologia 48(8), pp. 2303-2315. (10.1016/j.neuropsychologia.2010.03.018)
Honey, R. C., Iordanova, M. D. and Good, M. A. 2010. Latent inhibition and habituation: evaluation of an associative analysis. In: Lubow, R. and Weiner, I. eds. Latent Inhibition: Cognition, Neuroscience and Applications to Schizophrenia. Cambridge: Cambridge University Press, pp. 163-182., (10.1017/CBO9780511730184.009)

2009

Sanderson, D. J., Good, M. A., Skelton, K., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P. and Bannerman, D. M. 2009. Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model. Learning & Memory 16(6), pp. 379-386. (10.1101/lm.1339109)
Iordanova, M. D., Burnett, D. J., Aggleton, J. P., Good, M. A. and Honey, R. C. 2009. The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies. European Journal of Neuroscience 30(11), pp. 2177-2189. (10.1111/j.1460-9568.2009.07010.x)
Rhodes, S. E. V., Creighton, G., Killcross, A. S., Good, M. A. and Honey, R. C. 2009. Integration of geometric with luminance information in the rat: Evidence from within-compound associations. Journal of Experimental Psychology: Animal Behavior Processes 35(1), pp. 92-98. (10.1037/0097-7403.35.1.92)
McLeod, J., Curtis, N., Lewis, H. D., Good, M. A., Fagan, M. J. and Genever, P. G. 2009. γ-Secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior. FASEB Journal 23(9), pp. 2942-2955. (10.1096/fj.08-121657)

2008

Coles, B., Wilton, L. A. K., Good, M. A., Chapman, P. F. and Wann, K. T. 2008. Potassium channels in hippocampal neurones are absent in a transgenic but not in a chemical model of Alzheimer's disease. Brain Research 1190, pp. 1-14. (10.1016/j.brainres.2007.10.071)
Iordanova, M. D., Good, M. A. and Honey, R. C. 2008. Configural learning without reinforcement: Integrated memories for correlates of what, where, and when. Quarterly Journal of Experimental Psychology 61(12), pp. 1785-1792. (10.1080/17470210802194324)
Good, M. A. 2008. Spatio-temporal context and object recognition memory in rodents. In: Dere, E. et al. eds. Handbook of episodic memory. Handbook of behavioural neuroscience Vol. 18. Amsterdam: Elsevier, pp. 301-316.
Sanderson, D. J., Good, M. A., Seeburg, P. H., Sprengel, R., Rawlins, J. N. P. and Bannerman, D. M. 2008. The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory. In: Sossin, W. S. et al. eds. Essence of memory. Progress in brain research Vol. 169. Amsterdam: Elsevier, pp. 159-178., (10.1016/S0079-6123(07)00009-X)

2007

Jones, P. M., Pearce, J. M., Davies, V. J., Good, M. A. and McGregor, A. 2007. Impaired processing of local geometric features during navigation in a water maze following hippocampal lesions in rats. Behavioral Neuroscience 121(6), pp. 1258-1271. (10.1037/0735-7044.121.6.1258)
Johnson, A. W., Bannerman, D., Rawlins, N., Sprengel, R. and Good, M. A. 2007. Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Behavioral Neuroscience 121(6), pp. 1192-1202. (10.1037/0735-7044.121.6.1192)
Good, M. A. and Hale, G. 2007. The "Swedish" mutation of the amyloid precursor protein (APPswe) dissociates components of object-location memory in aged Tg2576 mice. Behavioral Neuroscience 121(6), pp. 1180-1191. (10.1037/0735-7044.121.6.1180)
Humeau, Y. et al. 2007. A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. Journal of Neuroscience 27(41), pp. 10947-10956. (10.1523/JNEUROSCI.2603-07.2007)
Sanderson, D. J. et al. 2007. Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory. Behavioral Neuroscience 121(3), pp. 559-569. (10.1037/0735-7044.121.3.559)
Good, M. A., Hale, G. and Staal, V. A. 2007. Impaired "episodic-like" object memory in adult APPswe transgenic mice. Behavioral Neuroscience 121(2), pp. 443-448. (10.1037/0735-7044.121.2.443)
Honey, R. C., Marshall, V. J., McGregor, A., Futter, J. E. and Good, M. A. 2007. Revisiting places passed: sensitization of exploratory activity in rats with hippocampal lesions. Quarterly Journal of Experimental Psychology 60(5), pp. 625-634. (10.1080/17470210601155252)
Good, M. A., Barnes, P. A., Staal, V. A., McGregor, A. and Honey, R. C. 2007. Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats. Behavioral Neuroscience 121(1), pp. 218-223. (10.1037/0735-7044.121.1.218)

2006

Bingman, V. P., Erichsen, J. T., Anderson, J. . D., Good, M. A. and Pearce, J. M. 2006. Spared feature-structure discrimination but diminished salience of environmental geometry in hippocampal-lesioned homing pigeons (Columba livia). Behavioral Neuroscience 120(4), pp. 835-841. (10.1037/0735-7044.120.4.835)
Pearce, J. M., Graham, M. A., Good, M. A., Jones, P. M. and McGregor, A. 2006. Potentiation, overshadowing, and blocking of spatial learning based on the shape of the environment. Journal of Experimental Psychology: Animal Behavior Processes 32(3), pp. 201-214. (10.1037/0097-7403.32.3.201)
Graham, M. A., Good, M. A., McGregor, A. and Pearce, J. M. 2006. Spatial learning based on the shape of the environment is influenced by properties of the objects forming the shape. Journal of Experimental Psychology: Animal Behavior Processes 32(1), pp. 44-59. (10.1037/0097-7403.32.1.44)
McGregor, A., Jones, P. M., Good, M. A. and Pearce, J. M. 2006. Further evidence that rats rely on local rather than global spatial information to locate a hidden goal: reply to Cheng and Gallistel (2005). Journal of Experimental Psychology: Animal Behavior Processes 32(3), pp. 314-321. (10.1037/0097-7403.32.3.314)
Barnes, P. A., Staal, V. A., Muir, J. L. and Good, M. A. 2006. 17-ß estradiol administration attenuates deficits in sustained and divided attention in young ovariectomized rats and aged acyclic female rats. Behavioral Neuroscience 120(6), pp. 1225-1234. (10.1037/0735-7044.120.6.1225)
Bannerman, D. M., Rawlins, J. N. P. and Good, M. A. 2006. The drugs don't work - or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory. Psychopharmacology 188(4), pp. 552-566. (10.1007/s00213-006-0403-6)
Sloan, H. L., Good, M. A. and Dunnett, S. B. 2006. Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task. Behavioural Brain Research 171(1), pp. 116-126. (10.1016/j.bbr.2006.03.030)

2005

Pearce, J. M., George, D. N., Haselgrove, M., Erichsen, J. T. and Good, M. A. 2005. The influence of hippocampal lesions on the discrimination of structure and on spatial memory in pigeons (Columba livia). Behavioral Neuroscience 119(5), pp. 1316-1330. (10.1037/0735-7044.119.5.1316)
Hale, G. and Good, M. A. 2005. Impaired visuo-spatial recognition memory but normal object novelty detection and relative familiarity judgements in adult mice expressing the APPswe Alzheimer's disease mutation. Behavioral Neuroscience 119(4), pp. 884-891. (10.1037/0735-7044.119.4.884)
Johnson, A. W., Bannerman, D. M., Rawlins, N. P., Sprengel, R. and Good, M. A. 2005. Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor GluR-1 subunit. Journal of Neuroscience 25(9), pp. 2359-2365. (10.1523/JNEUROSCI.4146-04.2005)
Barnes, P. and Good, M. A. 2005. Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behavioural Brain Research 157(1), pp. 107-117. (10.1016/j.bbr.2004.06.014)
Ramos-Esber, G., McGregor, A., Good, M. A., Hayward, A. and Pearce, J. M. 2005. Transfer of spatial behaviour controlled by a landmark array with a distinctive shape. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 58(1), pp. 69-91. (10.1080/02724990444000069)
Day, M. and Good, M. A. 2005. Ovariectomy-induced disruption of long-term synaptic depression in the hippocampal CA1 region in vivo is attenuated with chronic estrogen replacement. Neurobiology of Learning and Memory 83(1), pp. 13-21. (10.1016/j.nlm.2004.06.009)

2004

Barnes, P. A., Hale, G. and Good, M. A. 2004. Intramaze and extramaze cue processing in Tg2465 APPswe mutant mice. Behavioral Neuroscience 118(6), pp. 1184-1195. (10.1037/0735-7044.118.6.1184)
McGregor, A., Hayward, A. J., Pearce, J. M. and Good, M. A. 2004. Hippocampal lesions disrupt navigation based on the shape of the environment. Behavioral Neuroscience 118(5), pp. 1011-1021. (10.1037/0735-7044.118.5.1011)
Hayward, A. J., Good, M. A. and Pearce, J. M. 2004. Failure of a landmark to restrict spatial learning based on the shape of the environment. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 57(4), pp. 289-314. (10.1080/02724990344000150)
Pearce, J. M., Good, M. A., Jones, P. M. and McGregor, A. 2004. Transfer of spatial behavior between different environments: implications for theories of spatial learning and for the role of the hippocampus in spatial learning. Journal of Experimental Psychology: Animal Behavior Processes 30(2), pp. 135-147. (10.1037/0097-7403.30.2.135)
McGregor, A., Good, M. A. and Pearce, J. M. 2004. Absence of an interaction between navigational strategies based on local and distal landmarks. Journal of Experimental Psychology: Animal Behavior Processes 30(1), pp. 34-44. (10.1037/0097-7403.30.1.34)
Marshall, V. J., McGregor, A., Good, M. A. and Honey, R. C. 2004. Hippocampal Lesions Modulate Both Associative and Nonassociative Priming. Behavioral Neuroscience 118(2), pp. 377-382. (10.1037/0735-7044.118.2.377)

2003

Hayward, A., McGregor, A., Good, M. A. and Pearce, J. M. 2003. Absence of overshadowing and blocking between landmarks and the geometric cues provided by the shape of a test arena. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 56(1), pp. 114-126. (10.1080/02724990244000214)
Zheng, Y., Pearce, J. M., Vann, S. D., Good, M. A., Jenkins, T. A., Smith, P. F. and Aggleton, J. P. 2003. Using Idiothetic Cues to Swim a Path With a Fixed Trajectory and Distance: Necessary Involvement of the Hippocampus, but Not the Retrosplenial Cortex. Behavioral Neuroscience 117(6), pp. 1363-1377. (10.1037/0735-7044.117.6.1363)
Oswald, C. J. P., Bannerman, D. M., Yee, B. K., Rawlins, J. N. P., Honey, R. C. and Good, M. A. 2003. Entorhinal cortex lesions disrupt the transition between the use of intra- and extramaze cues for navigation in the water maze. Behavioral Neuroscience 117(3), pp. 588-595. (10.1037/0735-7044.117.3.588)

2002

Coutureau, E., Killcross, A. S., Good, M. A., Marshall, V. J., Ward-Robinson, J. and Honey, R. C. 2002. Acquired equivalence and distinctiveness of cues: II. Neural manipulations and their implications. Journal of Experimental Psychology: Animal Behavior Processes 28(4), pp. 388-396. (10.1037/0097-7403.28.4.388)
Oswald, C. J. P., Yee, B. K., Rawlins, J. N. P., Bannerman, D. B., Good, M. A. and Honey, R. C. 2002. The influence of selective lesions to components of the hippocampal system on the orientating response, habituation and latent inhibition. European Journal of Neuroscience 15(12), pp. 1983-1990. (10.1046/j.1460-9568.2002.02028.x)
Good, M. A. 2002. Spatial memory and hippocampal function: Where are we now?. Psicologica 23(1), pp. 109-138.
Bannerman, D., Lemaire, M., Yee, B., Iversen, S., Oswald, C., Good, M. A. and Rawlins, J. 2002. Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory. Experimental Brain Research 142(3), pp. 395-401. (10.1007/s00221-001-0938-z)

2001

Ward-Robinson, J., Coutureau, E., Good, M. A., Honey, R. C., Killcross, A. S. and Oswald, C. J. P. 2001. Excitotoxic lesions of the hippocampus leave sensory preconditioning intact: Implications for models of hippocampal function. Behavioral Neuroscience 115(6), pp. 1357-1362. (10.1037/0735-7044.115.6.1357)
Pearce, J. M., Ward-Robinson, J., Good, M. A., Fussell, C. J. and Aydin, A. 2001. Influence of a beacon on spatial learning based on the shape of the test environment. Journal of Experimental Psychology: Animal Behavior Processes 27(4), pp. 329-344. (10.1037/0097-7403.27.4.329)
Oswald, C. J. P., Yee, B. K., Rawlins, J. N. P., Bannerman, D. B., Good, M. A. and Honey, R. C. 2001. Involvement of the entorhinal cortex in a process of attentional modulation: Evidence from a novel variant of an IDS/EDS procedure. Behavioral Neuroscience 115(4), pp. 841-849. (10.1037/0735-7044.115.4.841)
Gray, N. S., Williams, J., Fernandez, M., Ruddle, R. A., Good, M. A. and Snowden, R. J. 2001. Context dependent latent inhibition in adult humans. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 54(3), pp. 233-245. (10.1080/713932760)
Bannerman, D. et al. 2001. The role of the entorhinal cortex in two forms of spatial learning and memory. Experimental Brain Research 141(3), pp. 281-303. (10.1007/s002210100868)
Bannerman, D., Yee, B., Lemaire, M., Jarrard, L., Iversen, S., Rawlins, J. and Good, M. A. 2001. Contextual fear conditioning is disrupted by lesions of the subcortical, but not entorhinal, connections to the hippocampus. Experimental Brain Research 141(3), pp. 304-311. (10.1007/s002210100869)

2000

Honey, R. C. and Good, M. A. 2000. Associative components of recognition memory. Current Opinion in Neurobiology 10(2), pp. 200-204. (10.1016/S0959-4388(00)00069-6)
Oswald, C. J. P. and Good, M. A. 2000. The effects of combined lesions of the subicular complex and the entorhinal cortex on two forms of spatial navigation in the water maze. Behavioral Neuroscience 114(1), pp. 211-217. (10.1037/0735-7044.114.1.211)
Aggleton, J. P., Vann, S. D., Oswald, C. J. P. and Good, M. A. 2000. Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer. Hippocampus 10(4), pp. 466-474. (10.1002/1098-1063(2000)10:4<466::AID-HIPO13>3.0.CO;2-Y)
Honey, R. C. and Good, M. A. 2000. Associative modulation of the orienting response: Distinct effects revealed by hippocampal lesions. Journal of Experimental Psychology: Animal Behavior Processes 26(1), pp. 3-14. (10.1037/0097-7403.26.1.3)

1999

Chapman, P. F. et al. 1999. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature Neuroscience 2(3), pp. 271-276. (10.1038/6374)
Bannerman, D. M., Yee, B. K., Good, M. A., Heupel, M. J., Iversen, S. D. and Rawlins, J. N. P. 1999. Double dissociation of function within the hippocampus: A comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions.. Behavioral Neuroscience 113(6), pp. 1170-1188. (10.1037/0735-7044.113.6.1170)
Good, M. A., Day, M. and Muir, J. L. 1999. Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region. European Journal of Neuroscience 11(12), pp. 4476-4480. (10.1046/j.1460-9568.1999.00920.x)

1998

Pearce, J. M., Roberts, A. D. L. and Good, M. A. 1998. Hippocampal lesions disrupt navigation based on cognitive maps but not heading vectors. Nature 396(6706), pp. 75-77. (10.1038/23941)
Honey, R. C., Watt, A. A. and Good, M. A. 1998. Hippocampal lesions disrupt an associative mismatch process. The Journal of Neuroscience 18(6), pp. 2226-2230.
Good, M. A., de Hoz, L. and Morris, R. G. M. 1998. Contingent versus incidental context processing during conditioning: Dissociation after excitotoxic hippocampal plus dentate gyrus lesions. Hippocampus 8(2), pp. 147-159. (10.1002/(SICI)1098-1063(1998)8:2<147::AID-HIPO7>3.0.CO;2-I)

1997

Redhead, E. S., Roberts, A., Good, M. A. and Pearce, J. M. 1997. Interaction between piloting and beacon homing by rats in a swimming pool. Journal of Experimental Psychology: Animal Behavior Processes 23(3), pp. 340-350. (10.1037/0097-7403.23.3.340)
Good, M. A. and Honey, R. C. 1997. Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning. Behavioral Neuroscience 111(3), pp. 487-493. (10.1037//0735-7044.111.3.487)
Bannerman, D. M., Butcher, S. P., Good, M. A. and Morris, R. G. M. 1997. Intracerebroventricular infusion of the NMDA receptor-associated glycine site antagonist 7-chlorokynurenate impairs water maze performance but fails to block hippocampal long-Term potentiation in vivo. Neurobiology of Learning and Memory 68(3), pp. 252-270. (10.1006/nlme.1997.3797)

1996

Good, M. A. 1996. Targeted deletion of neuronal nitric oxide: A step closer to understanding its functional significance?. Trends in Neurosciences 19(3), pp. 83-84. (10.1016/S0166-2236(96)80031-2)
Morris, R. G. M., Bannerman, D. M. and Good, M. A. 1996. NMDA receptors and spatial learning: Differential pretraining dissociates the behavioral effects of the receptor antagonist AP5 and selective hippocampal lesions. Presented at: Satellite Symposium of the Fourth IBRO World Congress of Neuroscience, Kyoto, Japan, 15-16 July 1995 Presented at Katō, N. ed.The Hippocampus: Functions and Clinical Relevance: proceedings of the satellite symposium of the Fourth IBRO World Congress of Neuroscience, Kyoto, Japan, 15-16 July, 1995. Developments in Neurology Vol. 11. Amsterdam: Elsevier pp. 55-76.

1995

Macphail, E. M., Good, M. A., Honey, R. C. and Willis, A. 1995. Relational learning in pigeons: The role of perceptual processes in between-key recognition of complex stimuli. Animal Learning & Behaviour 23(1), pp. 83-92. (10.3758/BF03198019)
Macphail, E. M., Good, M. A. and Honey, R. C. 1995. Recognition Memory in Pigeons for Stimuli Presented Repeatedly: Perceptual Learning or Reduced Associative Interference?. Quarterly Journal of Experimental Psychology Series B Comparative and Physiological Psychology 48(1), pp. 13-31. (10.1080/14640749508401434)
Morris, R. G. M., Bannerman, D. M., Good, M. and Ramsey, M. 1995. Prior experience dissociates components of N-Methyl-D-Aspartate- dependent forms of spatial learning in the watermaze [Abstract]. Behavioural Pharmacology 6(5-6), pp. 627.

1993

Honey, R. C. and Good, M. A. 1993. Selective hippocampal lesions abolish the contextual specificity of latent inhibition and conditioning. Behavioral Neuroscience 107(1), pp. 23-33. (10.1037/0735-7044.107.1.23)

1991

Good, M. A. and Honey, R. C. 1991. Conditioning and contextual retrieval in hippocampal rats. Behavioral Neuroscience 105(4), pp. 499-509. (10.1037/0735-7044.105.4.499)

Cyllid

BBSRC: Sylw a dysgu rhagfynegol (John Pearce) £574,671, 2010-2013

KTP: Gwell lipid sy'n cynnwys niwtraceuticals (John Harwood) £208,748, 2009-2011

Ysgoloriaeth Cymdeithas Alzheimer: Gwerthusiad o therapi gwrthgyrff newydd ar gyfer AD (Emma Kidd) £75,000, 2009-1011

Ymddiriedolaeth Ymchwil Alzheimer: Sail foleciwlaidd ar gyfer effeithiau buddiol asidau brasterog omega-3 (John Harwood £296,000, 2007-2011)

contract gwasanaeth NIH: gyda'r Athro Steve Goldberg: modiwleiddio derbynnydd cannabinoid o weithgaredd GABA mewn llygod APP $20,000 pa, 2010-11

Grŵp ymchwil

Niwrowyddoniaeth Ymddygiadol

Cydweithredwyr ymchwil

Yr Athro Robert Honey (Prifysgol Caerdydd)

Yr Athro John Harwood (Prifysgol Caerdydd)

Yr Athro John Pearce (Prifysgol Caerdydd)

Dr Emma Kidd (Prifysgol Caerdydd)

Dr. David Bannerman (Prifysgol Rhydychen)

Dr. Robert Williams (Prifysgol Caerfaddon)

Addysg israddedig

BSc. Seicoleg (2.1) Prifysgol Llundain

Addysg ôl-raddedig

DPhil. Behavioural Neuroscience University of York

Cyflogaeth

1990-1994. Prifysgol Caeredin. Post-doc. cymdeithasu.

1994 - i ddod. Darlithydd, Darllenydd a Chadeirydd Personol Prifysgol Caerdydd

Diddordebau ymchwil ôl-raddedig

Ar hyn o bryd mae myfyrwyr ôl-raddedig yn cynnal ymchwil a gyfeirir at ymchwilio i swbstradau niwral gwybyddiaeth anifeiliaid a gwerthuso therapïau cyfrifiadurol ar gyfer patholeg amyloid (gweler isod)

Os oes gennych ddiddordeb mewn gwneud cais am PhD, neu am ragor o wybodaeth am fy ymchwil ôl-raddedig, cysylltwch â mi'n uniongyrchol (manylion cyswllt ar gael ar y dudalen 'Trosolwg'), neu gyflwyno cais ffurfiol.

Myfyrwyr presennol

John Anderson – (ysgrifennu) Rôl ymwrthedd inswlin wrth ddatblygu patholeg amyloid. Gwobr BBSRC/GSK ACHOS

Katie Hall (cyfredol) Llid ychwanegion dietegol ar batholeg cof ac amyloid mewn modelau llygoden o Glefyd Alzheimer

Martha Hvoslefeide – (cyfredol) Effaith rhwystr sterig prosesu Ab ar wybyddiaeth mewn llygod APP

Laura Middleton (presennol) Priming mamol a chlefyd Alzheimer: Dylanwad diet ac ymarfer corff ar batholeg amyloid mewn model llygoden o Glefyd Alzheimer

Caroline O'Hagan (cyfredol) Dylanwad probioteg ar emosiwn a swyddogaeth weithredol mewn cnofilod

Alice Palmer (cyfredol) patholeg amyloid a phlastigrwydd synaptig hippocampal mewn modelau llygoden o Glefyd Alzheimer

Contact Details

Good@caerdydd.ac.uk
+44 29208 75867
Adeilad y Tŵr, Plas y Parc, Caerdydd, CF10 3AT

Yr Athro Mark Good BSc, DPhil

Trosolwyg