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Dr Irina Grigorieva
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Irina Grigorieva
Cymrawd Ymchwil
Trosolwg
Mae fy ymchwil yn mynd i'r afael â sut mae celloedd stromal mesenchymal meinwe-breswyl yn siapio datblygiad yr arennau, twf ac ymatebion i anafiadau. Rwy'n anelu at ddiffinio eu rhaglenni moleciwlaidd microamgylchedd-benodol a rhyngweithiadau cellog sy'n penderfynu a yw'r aren yn cael ei atgyweirio addasol neu'n symud ymlaen i ffibrosis.
Gan ddefnyddio omics un gell a thrawsgrifiad gofodol ar draws celloedd arennau >4M, rydym wedi cynhyrchu atlasau celloedd stromal cydraniad uchel yn ddiweddar sy'n rhychwantu twf arennau, iechyd a chlefyd. Mae'r setiau data hyn yn datgelu ffenoteipiau stromal moleciwlaidd gwahanol, is-setiau prin a chyflyrau celloedd deinamig sy'n gysylltiedig ag atgyweirio amddiffynnol neu gamaddasol. Rwy'n awr yn defnyddio'r adnoddau hyn i ddadansoddi'r mecanweithiau a'r rhwydweithiau signalau sy'n gyrru canlyniadau gwahanol, gan integreiddio modelau organoid in vitro, in vivo ac arennau.
Rwy'n cael fy ariannu gan Gymrodoriaeth Iris Bruton Kidney Research UK i ddiffinio priodweddau celloedd stromal amddiffynnol y gellir eu harneisio'n therapiwtig i hyrwyddo atgyweirio arennau a gwella canlyniadau i bobl sy'n byw gyda chlefyd yr arennau: https://www.kidneyresearchuk.org/2025/06/04/can-we-make-the-switch-from-kidney-damage-to-repair/
Cyhoeddiad
2026
- Roy, S. et al., 2026. Hyaluronan regulates vascular smooth muscle cell osteogenic differentiation and vascular calcification. Biomolecules 16 (5) 729. (10.3390/biom16050729)
2024
- Lu, Y. et al. 2024. Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing. Scientific Reports 14 (1) 24041. (10.1038/s41598-024-73102-7)
- Brown, C. V. M. et al. 2024. Protective effect of ischaemic preconditioning on acute and chronic renal damage following ischaemia reperfusion injury: characterisation of fibrosis development after inflammation resolution. International Journal of Clinical and Experimental Pathology 17 (4), pp.151-164. (10.62347/MFJG1164)
2023
- Grigorieva, I. et al. 2023. Hyaluronan in kidney fibrosis. In: Passi, A. ed. Hyaluronan: Structure, Biology and Biotechnology. Vol. 14, Biology of Extracellular Matrix Springer. , pp.77-97. (10.1007/978-3-031-30300-5_5)
2021
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32 (10), pp.2501-2516. (10.1681/ASN.2020081143)
- Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297 (3) 100987. (10.1016/j.jbc.2021.100987)
- Lines, K. E. et al., 2021. Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells. Endocrine Oncology 1 (1), pp.23-32. (10.1530/EO-21-0014)
2020
- Gaynor, K. U. et al., 2020. Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism. Endocrine Connections 9 (2), pp.173-186. (10.1530/EC-19-0478)
2019
- Grigorieva, I. V. et al. 2019. A novel role for GATA3 in mesangial cells in glomerular development and injury. Journal of the American Society of Nephrology 30 (9), pp.1641-1658. (10.1681/ASN.2018111143)
2013
- Gaynor, K. U. et al., 2013. GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness. Hormones and Cancer 4 (3), pp.123-139. (10.1007/s12672-013-0138-x)
2011
- Grigorieva, I. V. and Thakker, R. V. 2011. Transcription factors in parathyroid development: lessons from hypoparathyroid disorders. Annals of the New York Academy of Sciences 1237 (1), pp.24-38. (10.1111/j.1749-6632.2011.06221.x)
2010
- Grigorieva, I. V. et al. 2010. Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. Journal of Clinical Investigation 120 (6), pp.2144-2155. (10.1172/JCI42021)
- Bowl, M. R. et al., 2010. Identification and characterization of novel parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutations in eight families with autosomal recessive hypoparathyroidism. Human Molecular Genetics 19 (10), pp.2028-2038. (10.1093/hmg/ddq084)
2009
- Gaynor, K. U. et al., 2009. A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. Journal of Clinical Endocrinology and Metabolism 94 (10), pp.3897-3904. (10.1210/jc.2009-0717)
2007
- Ali, A. et al., 2007. Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor. Human Molecular Genetics 16 (3), pp.265-275. (10.1093/hmg/ddl454)
Adrannau llyfrau
- Grigorieva, I. et al. 2023. Hyaluronan in kidney fibrosis. In: Passi, A. ed. Hyaluronan: Structure, Biology and Biotechnology. Vol. 14, Biology of Extracellular Matrix Springer. , pp.77-97. (10.1007/978-3-031-30300-5_5)
Erthyglau
- Roy, S. et al., 2026. Hyaluronan regulates vascular smooth muscle cell osteogenic differentiation and vascular calcification. Biomolecules 16 (5) 729. (10.3390/biom16050729)
- Lu, Y. et al. 2024. Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing. Scientific Reports 14 (1) 24041. (10.1038/s41598-024-73102-7)
- Brown, C. V. M. et al. 2024. Protective effect of ischaemic preconditioning on acute and chronic renal damage following ischaemia reperfusion injury: characterisation of fibrosis development after inflammation resolution. International Journal of Clinical and Experimental Pathology 17 (4), pp.151-164. (10.62347/MFJG1164)
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32 (10), pp.2501-2516. (10.1681/ASN.2020081143)
- Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297 (3) 100987. (10.1016/j.jbc.2021.100987)
- Lines, K. E. et al., 2021. Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells. Endocrine Oncology 1 (1), pp.23-32. (10.1530/EO-21-0014)
- Gaynor, K. U. et al., 2020. Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism. Endocrine Connections 9 (2), pp.173-186. (10.1530/EC-19-0478)
- Grigorieva, I. V. et al. 2019. A novel role for GATA3 in mesangial cells in glomerular development and injury. Journal of the American Society of Nephrology 30 (9), pp.1641-1658. (10.1681/ASN.2018111143)
- Gaynor, K. U. et al., 2013. GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness. Hormones and Cancer 4 (3), pp.123-139. (10.1007/s12672-013-0138-x)
- Grigorieva, I. V. and Thakker, R. V. 2011. Transcription factors in parathyroid development: lessons from hypoparathyroid disorders. Annals of the New York Academy of Sciences 1237 (1), pp.24-38. (10.1111/j.1749-6632.2011.06221.x)
- Grigorieva, I. V. et al. 2010. Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. Journal of Clinical Investigation 120 (6), pp.2144-2155. (10.1172/JCI42021)
- Bowl, M. R. et al., 2010. Identification and characterization of novel parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) mutations in eight families with autosomal recessive hypoparathyroidism. Human Molecular Genetics 19 (10), pp.2028-2038. (10.1093/hmg/ddq084)
- Gaynor, K. U. et al., 2009. A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. Journal of Clinical Endocrinology and Metabolism 94 (10), pp.3897-3904. (10.1210/jc.2009-0717)
- Ali, A. et al., 2007. Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor. Human Molecular Genetics 16 (3), pp.265-275. (10.1093/hmg/ddl454)
Addysgu
Cyfrannwr y modiwl: Peirianneg Meinwe a Meddygaeth Adfywiol (MSc)
Bywgraffiad
Addysg
D.Phil.
Prifysgol Rhydychen (Coleg Wolfson), Uned Endocrin Academaidd, Adran Meddygaeth Radcliffe
BSc (Anrh)
Biocemeg, Coleg Imperial Llundain
Cymrodoriaethau
2025 – Cymrodoriaeth Kidney Research UK, Prifysgol Caerdydd
2015 – Cymrodoriaeth Marie Curie, Prifysgol Feddygol Fienna, Awstria
2010 – Cymrodoriaeth Cymdeithas Endocrinoleg, Prifysgol Georgia, UDA
Swyddi academaidd ôl-ddoethurol
Yr Is-adran Heintiau ac Imiwnedd, Ysgol Feddygaeth, Prifysgol Caerdydd, DU
Grŵp Arennol, Prifysgol Feddygol Fienna, Awstria
Uned Endocrin Academaidd, Adran Meddygaeth Radcliffe, Prifysgol Rhydychen, DU