Dr Nathan Harmston
(e/fe)
BSc, MSc, PhD
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Nathan Harmston
Darlithydd
Biowyddorau Moleciwlaidd
Trosolwg
Rwy'n fiolegydd cyfrifiannol sydd â diddordeb mewn deall sut mae mynegiant genynnau yn cael ei reoleiddio yn ystod y ddau ddatblygiad - gyda ffocws ar Drosophila - ac yng nghyd-destun clefyd; Yn enwedig canser.
Mae fy niddordebau ymchwil yn cwmpasu amrywiaeth o themâu, gan gynnwys deall sut mae'r strwythur 3D o amgylch ffactorau trawsgrifio pwysig yn dylanwadu ar esblygiad genom a nodi'r nodweddion genomig ac epigenetig sy'n penderfynu a yw genyn yn cael ei reoleiddio gan lwybr signalau datblygiadol penodol. Mae fy ngwaith diweddar wedi canolbwyntio ar ddeall llwybr signalau WNT yn well gan ddefnyddio dulliau trawsgrifio.
Rydym yn defnyddio nifer o ddulliau cyfrifiadurol ac ystadegol i ofyn ac ateb cwestiynau am systemau biolegol, yn aml mewn cydweithrediad agos â biolegwyr arbrofol.
Cyhoeddiad
2026
- Liu, S. et al., 2026. Identification of Wnt‐regulated genes that are repressed by, or independent of, β‐catenin. The FEBS Journal 293 (12), pp.3621-3639. (10.1111/febs.70417)
- Goh, K. Y. et al., 2026. Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles. Nature Communications 17 5750. (10.1038/s41467-026-72410-y)
2025
- Choy, S. M. et al., 2025. Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. Proceedings of the National Academy of Sciences 122 (48) e2508893122. (10.1073/pnas.2508893122)
- Ang, D. A. , Harmston, N. and Li, Y. 2025. ATF4:p52 Complex activates oncogenic enhancers in multiple myeloma via p300/CBP recruitment to regulate BACH1. Cancer Letters 623 217727. (10.1016/j.canlet.2025.217727)
2024
- Goh, K. Y. et al., 2024. FOXO-regulated DEAF1 controls muscle regeneration through autophagy. Autophagy 20 (12), pp.2632-2654. (10.1080/15548627.2024.2374693)
- Ang, D. A. et al., 2024. Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma. Nature Communications 15 (1) 2513. (10.1038/s41467-024-46728-4)
- Madan, B. et al., 2024. The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling. The Journal of Clinical Investigation 134 (6) e171222. (10.1172/JCI171222)
- Tan, Q. H. et al., 2024. The Wnt co-receptor PTK7/Otk and Its Homolog Otk-2 in neurogenesis and patterning. Cells 13 (5) 365. (10.3390/cells13050365)
2022
- Zhong, Z. et al., 2022. A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models. Journal of Clinical Investigation 132 (12) e156305. (10.1172/JCI156305)
- Lusk, J. B. et al., 2022. A non-canonical Raf function is required for dorsal–ventral patterning during Drosophila embryogenesis. Scientific Reports 12 7684. (10.1038/s41598-022-11699-3)
- Kaur, P. et al., 2022. Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan. [Online].bioRXiv. (10.1101/2022.04.21.488994)Available at: https://doi.org/10.1101/2022.04.21.488994.
- Chua, E. H. Z. , Yasar, S. and Harmston, N. 2022. The importance of considering regulatory domains in genome-wide analyses – the nearest gene is often wrong!. Biology Open 11 (4) bio059091. (10.1242/bio.059091)
- Kaur, P. et al., 2022. Wnt signaling rescues amyloid beta-induced gut stem cell loss. Cells 11 (2) 281. (10.3390/cells11020281)
2021
- Harmston, N. et al. 2021. Widespread repression of gene expression in cancer by a Wnt/β-Catenin/MAPK pathway. Cancer Research 81 (2), pp.464-475. (10.1158/0008-5472.CAN-20-2129)
2020
- Yu, J. et al., 2020. The functional landscape of patient-derived RNF43 mutations predicts sensitivity to Wnt inhibition. Cancer Research 80 (24), pp.5619-5632. (10.1158/0008-5472.CAN-20-0957)
- Kaur, A. et al., 2020. WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. [Online].bioRXiv: bioRXiv. (10.1101/2020.06.17.157024)Available at: https://doi.org/10.1101/2020.06.17.157024.
- Yu, J. et al., 2020. The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity. [Online].bioRXiv: bioRXiv. (10.1101/2020.03.25.006999)Available at: https://doi.org/10.1101/2020.03.25.006999.
- Yapp, L. et al., 2020. In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors.. Cell Reports 26 (12), pp.3231-3245. (10.1016/j.celrep.2019.02.083)
- Liu, S. et al., 2020. Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. null (10.1101/2020.02.09.941005)
2019
- Idris, M. et al., 2019. Broad regulation of gene isoform expression by Wnt signaling in cancer. RNA 25 (12), pp.1696-1713. (10.1261/rna.071506.119)
- Chen, H. et al., 2019. WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.. Nature Communications 10 3616. (10.1038/s41467-019-11551-9)
- Bardile, C. F. et al., 2019. Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America 116 (19), pp.9622-9627. (10.1073/pnas.1818042116)
- Ooi, J. et al., 2019. Unbiased profiling of Isogenic Huntington Disease hPSC-Derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects. Cell Reports 26 (9), pp.2494-2508. (10.1016/j.celrep.2019.02.008)
- Bagnati, M. et al., 2019. Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing.. JCI Insight 4 (2) 2379-3708. (10.1172/jci.insight.125736)
2018
- Madan, B. et al., 2018. Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis.. JCI Journal of Clinical Investigation 128 (12), pp.5620-5633. (10.1172/JCI122383)
- Tjin, M. S. et al., 2018. Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture.. Nature Communications 9 4432. (10.1038/s41467-018-06934-3)
- Moreno-Moral, A. et al., 2018. Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk.. Annals of the Rheumatic Diseases 77 , pp.596-601. (10.1136/annrheumdis-2017-212454)
2017
- Suresh, J. et al., 2017. An embryonic system to assess direct and indirect Wnt transcriptional targets.. Scientific Reports 7 11092. (10.1038/s41598-017-11519-z)
- Harmston, N. et al. 2017. Topologically associated domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation. Nature Communications 8 441. (10.1101/042952)
- Alok, A. et al., 2017. Wnt proteins synergize to activate β-catenin signaling. Development 144 (10), pp.e1.1-e1.1. (10.1242/dev.154112)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome Bisulfite sequencing data identifies disease-associated changes in DNA Methylation.. Genetics 205 (4), pp.1443–1458. (10.1534/genetics.116.195008)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome bisulphite sequencing data identifies disease-associated changes in DNA methylation. null (10.1101/041715)
2016
- Madan, B. et al., 2016. Wnt addiction of genetically defined cancers reversed by PORCN inhibition.. Oncogene 35 , pp.2197-2207. (10.1038/onc.2015.280)
- Rackham, J. O. et al., 2016. Approximate Bayesian bisulphite sequencing analysis. null (10.1101/041715)
2015
- Harmston, N. et al. 2015. GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data. BMC Genomics 16 (1) 963. (10.1186/s12864-015-2140-x)
2013
- Harmston, N. , Barešić, A. and Lenhard, B. 2013. The mystery of extreme non-coding conservation.. Philosophical Transactions of the Royal Society B: Biological Sciences 368 (1632) 20130021. (10.1098/rstb.2013.0021)
- Harmston, N. and Lenhard, B. 2013. Chromatin and epigenetic features of long-range gene regulation.. Nucleic Acids Research 41 (15), pp.7185-7199. (10.1093/nar/gkt499)
2011
- Harmston, N. , Filsell, W. and Stumpf, M. P. 2011. Which species is it? Species-driven gene name disambiguation using random walks over a mixture of adjacency matrices.. Bioinformatics 28 (2), pp.254-260. (10.1093/bioinformatics/btr640)
2010
- Harmston, N. , Filsell, W. and Stumpf, M. P. 2010. What the papers say: Text mining for genomics and systems biology. Human Genomics 5 (1) 17. (10.1186/1479-7364-5-1-17)
Articles
- Liu, S. et al., 2026. Identification of Wnt‐regulated genes that are repressed by, or independent of, β‐catenin. The FEBS Journal 293 (12), pp.3621-3639. (10.1111/febs.70417)
- Goh, K. Y. et al., 2026. Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles. Nature Communications 17 5750. (10.1038/s41467-026-72410-y)
- Choy, S. M. et al., 2025. Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging. Proceedings of the National Academy of Sciences 122 (48) e2508893122. (10.1073/pnas.2508893122)
- Ang, D. A. , Harmston, N. and Li, Y. 2025. ATF4:p52 Complex activates oncogenic enhancers in multiple myeloma via p300/CBP recruitment to regulate BACH1. Cancer Letters 623 217727. (10.1016/j.canlet.2025.217727)
- Goh, K. Y. et al., 2024. FOXO-regulated DEAF1 controls muscle regeneration through autophagy. Autophagy 20 (12), pp.2632-2654. (10.1080/15548627.2024.2374693)
- Ang, D. A. et al., 2024. Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma. Nature Communications 15 (1) 2513. (10.1038/s41467-024-46728-4)
- Madan, B. et al., 2024. The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling. The Journal of Clinical Investigation 134 (6) e171222. (10.1172/JCI171222)
- Tan, Q. H. et al., 2024. The Wnt co-receptor PTK7/Otk and Its Homolog Otk-2 in neurogenesis and patterning. Cells 13 (5) 365. (10.3390/cells13050365)
- Zhong, Z. et al., 2022. A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models. Journal of Clinical Investigation 132 (12) e156305. (10.1172/JCI156305)
- Lusk, J. B. et al., 2022. A non-canonical Raf function is required for dorsal–ventral patterning during Drosophila embryogenesis. Scientific Reports 12 7684. (10.1038/s41598-022-11699-3)
- Chua, E. H. Z. , Yasar, S. and Harmston, N. 2022. The importance of considering regulatory domains in genome-wide analyses – the nearest gene is often wrong!. Biology Open 11 (4) bio059091. (10.1242/bio.059091)
- Kaur, P. et al., 2022. Wnt signaling rescues amyloid beta-induced gut stem cell loss. Cells 11 (2) 281. (10.3390/cells11020281)
- Harmston, N. et al. 2021. Widespread repression of gene expression in cancer by a Wnt/β-Catenin/MAPK pathway. Cancer Research 81 (2), pp.464-475. (10.1158/0008-5472.CAN-20-2129)
- Yu, J. et al., 2020. The functional landscape of patient-derived RNF43 mutations predicts sensitivity to Wnt inhibition. Cancer Research 80 (24), pp.5619-5632. (10.1158/0008-5472.CAN-20-0957)
- Yapp, L. et al., 2020. In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors.. Cell Reports 26 (12), pp.3231-3245. (10.1016/j.celrep.2019.02.083)
- Liu, S. et al., 2020. Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation. null (10.1101/2020.02.09.941005)
- Idris, M. et al., 2019. Broad regulation of gene isoform expression by Wnt signaling in cancer. RNA 25 (12), pp.1696-1713. (10.1261/rna.071506.119)
- Chen, H. et al., 2019. WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.. Nature Communications 10 3616. (10.1038/s41467-019-11551-9)
- Bardile, C. F. et al., 2019. Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America 116 (19), pp.9622-9627. (10.1073/pnas.1818042116)
- Ooi, J. et al., 2019. Unbiased profiling of Isogenic Huntington Disease hPSC-Derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects. Cell Reports 26 (9), pp.2494-2508. (10.1016/j.celrep.2019.02.008)
- Bagnati, M. et al., 2019. Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing.. JCI Insight 4 (2) 2379-3708. (10.1172/jci.insight.125736)
- Madan, B. et al., 2018. Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis.. JCI Journal of Clinical Investigation 128 (12), pp.5620-5633. (10.1172/JCI122383)
- Tjin, M. S. et al., 2018. Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture.. Nature Communications 9 4432. (10.1038/s41467-018-06934-3)
- Moreno-Moral, A. et al., 2018. Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk.. Annals of the Rheumatic Diseases 77 , pp.596-601. (10.1136/annrheumdis-2017-212454)
- Suresh, J. et al., 2017. An embryonic system to assess direct and indirect Wnt transcriptional targets.. Scientific Reports 7 11092. (10.1038/s41598-017-11519-z)
- Harmston, N. et al. 2017. Topologically associated domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation. Nature Communications 8 441. (10.1101/042952)
- Alok, A. et al., 2017. Wnt proteins synergize to activate β-catenin signaling. Development 144 (10), pp.e1.1-e1.1. (10.1242/dev.154112)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome Bisulfite sequencing data identifies disease-associated changes in DNA Methylation.. Genetics 205 (4), pp.1443–1458. (10.1534/genetics.116.195008)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome bisulphite sequencing data identifies disease-associated changes in DNA methylation. null (10.1101/041715)
- Madan, B. et al., 2016. Wnt addiction of genetically defined cancers reversed by PORCN inhibition.. Oncogene 35 , pp.2197-2207. (10.1038/onc.2015.280)
- Rackham, J. O. et al., 2016. Approximate Bayesian bisulphite sequencing analysis. null (10.1101/041715)
- Harmston, N. et al. 2015. GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data. BMC Genomics 16 (1) 963. (10.1186/s12864-015-2140-x)
- Harmston, N. , Barešić, A. and Lenhard, B. 2013. The mystery of extreme non-coding conservation.. Philosophical Transactions of the Royal Society B: Biological Sciences 368 (1632) 20130021. (10.1098/rstb.2013.0021)
- Harmston, N. and Lenhard, B. 2013. Chromatin and epigenetic features of long-range gene regulation.. Nucleic Acids Research 41 (15), pp.7185-7199. (10.1093/nar/gkt499)
- Harmston, N. , Filsell, W. and Stumpf, M. P. 2011. Which species is it? Species-driven gene name disambiguation using random walks over a mixture of adjacency matrices.. Bioinformatics 28 (2), pp.254-260. (10.1093/bioinformatics/btr640)
- Harmston, N. , Filsell, W. and Stumpf, M. P. 2010. What the papers say: Text mining for genomics and systems biology. Human Genomics 5 (1) 17. (10.1186/1479-7364-5-1-17)
Websites
- Kaur, P. et al., 2022. Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan. [Online].bioRXiv. (10.1101/2022.04.21.488994)Available at: https://doi.org/10.1101/2022.04.21.488994.
- Kaur, A. et al., 2020. WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. [Online].bioRXiv: bioRXiv. (10.1101/2020.06.17.157024)Available at: https://doi.org/10.1101/2020.06.17.157024.
- Yu, J. et al., 2020. The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity. [Online].bioRXiv: bioRXiv. (10.1101/2020.03.25.006999)Available at: https://doi.org/10.1101/2020.03.25.006999.
Addysgu
Ar hyn o bryd rwy'n ymwneud ag addysgu bioleg gyfrifiadurol a sgiliau dadansoddi data fel rhan o'r MSc Bioleg Data Mawr.
Rolau addysgu blaenorol
Athro Cynorthwyol @ Yale-NUS
- Ymchwiliad Gwyddonol I
- Ystadegau ar gyfer Gwyddorau Bywyd
- Bioleg Gyfrifiadurol a Systemau
- Pynciau Uwch mewn Bioleg Gyfrifiadurol a Systemau
Bywgraffiad
Safleoedd academaidd blaenorol
Swyddi blaenorol
- Athro Cynorthwyol @ Yale-NUS, Singapôr - 2019-2023
- Athro Cynorthwyol @Duke-NUS, Singapôr - 2019-2023
- Uwch Gymrawd Ymchwil @Duke-NUS, Singapore - 2015-2019
- Cymrawd Datblygu Gyrfa @ MRC CSC (LMS bellach), Llundain, 2012-2015
Addysg
- PhD @ Imperial College Llundain (2008-2012)
- MSc - Biowybodeg a Bioleg Systemau Damcaniaethol - Coleg Imperial Llundain - (2007 - 2008)
- BSc (Anrh) - Cyfrifiadureg - Prifysgol Nottingham - (2002 - 2006)
Pwyllgorau ac adolygu
adolygydd ar gyfer cylchgronau lluosog
Aelod o'r Pwyllgor Uniondeb Academaidd @ Yale-NUS - 2021 - 2022
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Kieran Howard
Contact Details
Themâu ymchwil
Arbenigeddau
- Biowybodeg a bioleg gyfrifiadurol
- Genomeg a thrawsgrifiadau