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Dr Sally Hayes
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Sally Hayes
Uwch Gymrawd Ymchwil, Hwylusydd Ymchwil
Cynorthwy-ydd Gweinyddol
TAITH
Trosolwyg
After graduating from Aberystwyth University in 2000 with a First Class Honours in Animal (Equine) Science, I took up a 5-year MRC funded Research Assistant post within the Structural Biophysics Group at Cardiff University to investigate the relationship between corneal structure and function. In 2005 I was awarded a PhD for my research into the structural organisation of collagen in the corneas of primates and other animals and the stromal changes associated with the disease keratoconus. Since then, I have continued to follow this line of research as a post-doctorate scientist.
Research Interests
My current research is aimed at further understanding the relationship between structure and function in normal and diseased corneas. I am particularly interested in keratoconus, a disease characterised by progressive thinning and steepening of the cornea and severe irregular astigmatism. Keratoconus is one of the leading causes of corneal transplant surgery in the UK.
Using a combination of videokeratography to assess corneal shape, and synchrotron x-ray diffraction to gain quantitative structural information about the organisation and distribution of collagen in normal and keratoconus corneas, we attempted to form a link between corneal structure and specific keratoconus shape changes and proposed a mechanism (involving lamellar slippage) that may explain how the keratoconus cornea thins and steepens. In recent years a therapeutic treatment has been developed to halt these changes. The treatment involves the use of UVA/riboflavin cross linking to stabilise the collagen and its surrounding matrix and my primary interest at present is to identify precisely how this occurs.
I am also very interested in human corneal development, in particular the structural changes that lead to the cornea becoming strong, transparent and precisely curved. Recently granted access to the MRC/Wellcome Trust-funded Human Developmental Biology Resource (HDBR) has provided us with a unique opportunity to examine structural changes occurring at key stages of foetal development.
Selected Publications
Hayes, S., Boote, C., Tuft, S., Quantock, A. and Meek, K. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and x-ray scattering techniques. Experimental Eye Research. 84. 423-434.
Hayes S , Boote C, Lewis J, Sheppard J, Abahussin M, Quantock AJ, Purslow C, Votruba M, Meek KM. 2007. Comparative study of fibrillar collagen arrangement in the corneas of primates and other mammals. Anatomical Record (Hoboken). 290(12):1542-50.
Hayes S , O'Brart DP, Lamdin LS, Doutch J, Samaras K, Marshall J, Meek KM. 2008. Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy. Journal of Cataract and Refractive Surgery. 34(4):657-61
Hayes S, Boote C, Kamma-Lorger CS, Rajan MS, Harris J, Dooley E, Hawksworth N, Hiller J, Terill NJ, Hafezi F, Brahma AK, Quantock AJ and Meek KM. Riboflavin/UVA collagen cross-linking-induced changes in normal and keratoconus corneal stroma. PloS One. 2011; 6(8): e22405
Cyhoeddiad
2026
- Kollros, L. et al., 2026. Dehydration and rehydration behavior of ultra-high-fluence Extracorporeal Cross-Linked Corneal Allogenic Intrastromal Ring Segments (ECO-CAIRS). Journal of Cataract and Refractive Surgery (10.1097/j.jcrs.0000000000002015)
- Bains, K. K. et al. 2026. The structural order of crystallin proteins during early human lens development. Investigative Ophthalmology & Visual Science 67 (1) 50. (10.1167/iovs.67.1.50)
- Borgia, A. et al., 2026. Corneal stromal thinning and posterior irregularity after DMEK: Clinical observations and biophysical hypotheses. Cornea: The Journal of Cornea and External Disease (10.1097/ico.0000000000004084)
2025
- Wang, X. et al. 2025. The correlation between myopia severity and stress-strain index (SSI) using the Corneal Visualization Scheimpflug Technology (Corvis ST). Scientific Reports 15 (1) 40103. (10.1038/s41598-025-23834-x)
- Bell, J. et al. 2025. Hierarchical biomechanical characterisation of riboflavin-UVA crosslinking and decorin treatment in the porcine cornea. Frontiers in Bioengineering and Biotechnology 13 1603679. (10.3389/fbioe.2025.1603679)
- Wang, X. et al. 2025. Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies. Eye and Vision 12 (1) 18. (10.1186/s40662-025-00435-3)
- Meek, K. M. et al. 2025. Structural control of corneal transparency, refractive power and dynamics. Eye 39 , pp.644-650. (10.1038/s41433-024-02969-7)
2024
- Yang, M. et al., 2024. Development of graphitic carbon nitride quantum dots-based oxygen self-sufficient platforms for enhanced corneal crosslinking. Nature Communications 15 5508. (10.1038/s41467-024-49645-8)
- Morgan, S. R. et al. 2024. An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking. Eye and Vision 11 (8)(10.1186/s40662-024-00375-4)
2023
- Hayes, S. et al. 2023. National survey of corneal cross-linking (CXL) practice patterns in the United Kingdom during 2019. Eye 37 , pp.2511-2517. (10.1038/s41433-022-02365-z)
2022
- Gao, R. et al., 2022. The impact of different rose bengal formulations on corneal thickness and the efficacy of rose bengal/green light corneal cross-linking in the rabbit eye. Journal of Refractive Surgery 38 (7), pp.450-458. (10.3928/1081597X-20220601-03)
- Bell, J. et al. 2022. The hierarchical response of human corneal collagen to controlled inflation. Investigative Ophthalmology & Visual Science 63 (7) 2392 – A0195.
- Bell, J. S. et al. 2022. Tropocollagen springs allow collagen fibrils to stretch elastically. Acta Biomaterialia 142 , pp.185-193. (10.1016/j.actbio.2022.01.041)
2021
- Zhou, D. et al., 2021. Fibril density reduction in keratoconic corneas. Journal of the Royal Society Interface 18 (175) 20200900. (10.1098/rsif.2020.0900)
- Hayes, S. , Morgan, S. R. and Meek, K. M. 2021. Keratoconus: cross-linking the window of the eye. Therapeutic Advances in Rare Disease 2 , pp.1-14. (10.1177/26330040211003573)
2020
- Hayes, S. et al. 2020. The effect of bacteriochlorophyll derivative WST-D and near infrared light on the molecular and fibrillar architecture of the corneal stroma. Scientific Reports 10 9836. (10.1038/s41598-020-66869-y)
- Meek, K. M. et al. 2020. X-ray diffraction imaging of corneal ultrastructure. In: Ahearne, M. ed. Corneal Regeneration: Methods and Protocols. Vol. 2145, Methods in Molecular Biology New York, NY, USA: Humana. , pp.231-247. (10.1007/978-1-0716-0599-8_16)
- Feneck, E. M. et al. 2020. Developmental abnormalities in the cornea of a mouse model for Marfan syndrome. Experimental Eye Research 194 108001. (10.1016/j.exer.2020.108001)
2018
- Morgan, S. et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8 13742. (10.1038/s41598-018-32110-0)
- Bell, J. et al. 2018. A subfibrillar deformation mechanism in corneal collagen that affords flexibility [Abstract]. Investigative Ophthalmology & Visual Science 59 (9) 1415.
- Hayes, S. , Meek, K. and Mukherjee, A. 2018. Use of donors predisposed by corneal collagen cross-linking in penetrating keratoplasty for treating patients with keratoconus. American Journal of Ophthalmology 188 , pp.181-181. (10.1016/j.ajo.2017.12.026)
- Pinsky, P. M. et al., 2018. A simple mathematical model for collagen fibril organization in normal and keratoconic corneas. Journal for Modeling in Ophthalmology 1
- O'Brart, N. et al., 2018. An investigation of the effects of riboflavin concentration on the efficacy of corneal cross-linking using an enzymatic resistance model in porcine corneas. Investigative Ophthalmology and Visual Science 59 , pp.1058-1065. (10.1167/iovs.17-22994)
- Bell, J. S. et al. 2018. The hierarchical response of human corneal collagen to load. Acta Biomaterialia 65 , pp.216-225. (10.1016/j.actbio.2017.11.015)
- Islam, M. M. et al., 2018. Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation. npj Regenerative Medicine 3 2. (10.1038/s41536-017-0038-8)
- O’Brart, D. P. S. et al., 2018. The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking. Investigative Ophthalmology and Visual Science 59 , pp.4449-4450. (10.1167/iovs.18-24437)
2017
- Abass, A. et al., 2017. SAXS4COLL: an integrated software tool for analysing fibrous collagen-based tissues. Journal of Applied Crystallography 50 , pp.1235-1240. (10.1107/S1600576717007877)
- Hayes, S. et al. 2017. The structural response of the cornea to changes in stromal hydration. Interface 14 (131)(10.1098/rsif.2017.0062)
- White, T. et al. 2017. The structural role of elastic fibres in the cornea investigated using a mouse model for Marfan syndrome. Investigative Ophthalmology and Vision Science 58 (4), pp.2106-2116. (10.1167/iovs.16-21358)
2016
- Aldahlawi, N. H. et al. 2016. An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols. Experimental Eye Research 153 , pp.141-151. (10.1016/j.exer.2016.10.014)
- Aldahlawi, N. H. et al. 2016. Enzymatic resistance of corneas crosslinked using riboflavin in conjunction with low energy, high energy, and pulsed UVA irradiation modes. Investigative Ophthalmology & Visual Science 57 (4), pp.1547-1552. (10.1167/iovs.15-18769)
2015
- Hayes, S. et al. 2015. The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia 25 , pp.121-130. (10.1016/j.actbio.2015.07.009)
- Hayes, S. et al. 2015. A study of stromal riboflavin absorption inex vivoporcine corneas using new and existing delivery protocols for corneal cross-linking. Acta Ophthalmologica 94 (2), pp.e109-e117. (10.1111/aos.12884)
- Mukherjee, A. et al., 2015. Donor cross-linking for keratoplasty: a laboratory evaluation. Graefe's Archive for Clinical and Experimental Ophthalmology 252 (12), pp.2223-2228. (10.1007/s00417-015-3160-6)
- Aldahlawi, N. et al. 2015. Standard versus accelerated riboflavin/ultraviolet corneal cross-linking: Resistance against enzymatic digestion. Journal of Cataract and Refractive Surgery 41 (9), pp.1989-1996. (10.1016/j.jcrs.2015.10.004)
- Abass, A. et al. 2015. Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society Interface 12 (104) 20140717. (10.1098/rsif.2014.0717)
2013
- Davidson, A. E. et al., 2013. The pathogenesis of keratoconus. Eye 28 (2), pp.189-195. (10.1038/eye.2013.278)
- Abahussin, M. et al., 2013. A microscopy study of the structural features of post-LASIK human corneas. PLoS ONE 8 (5) e63268. (10.1371/journal.pone.0063268)
- Hayes, S. et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8 (1) e52860. (10.1371/journal.pone.0052860)
- Boote, C. et al. 2013. Quantification of Collagen Ultrastructure after Penetrating Keratoplasty - Implications for Corneal Biomechanics. PLoS ONE 8 (7) e68166. (10.1371/journal.pone.0068166)
- Meek, K. M. A. and Hayes, S. 2013. Corneal crosslinking - A review. Ophthalmic and Physiological Optics 33 (2), pp.78-93. (10.1111/opo.12032)
2012
- Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53 (6), pp.2786-2795. (10.1167/iovs.11-9305)
- Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130 (2), pp.251-252. (10.1001/archopthalmol.2011.1467)
2011
- Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101 (1), pp.33-42. (10.1016/j.bpj.2011.05.029)
- Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6 (8) e22405. (10.1371/journal.pone.0022405)
- Hayes, S. et al. 2011. The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. Molecular Vision 17 , pp.3107-3115.
2010
- Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169 (3), pp.424-430. (10.1016/j.jsb.2009.11.004)
- Sheppard, J. et al. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51 (6), pp.2936-2942. (10.1167/iovs.09-4612)
2009
- Kamma-Lorger, C. S. et al. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88 (5), pp.953-959. (10.1016/j.exer.2008.12.005)
- Abahussin, M. O. et al. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50 (11), pp.5159-5164. (10.1167/iovs.09-3669)
- Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166 (2), pp.195-204. (10.1016/j.jsb.2009.01.009)
- Hayes, S. et al. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24 (4), pp.728-734. (10.1038/eye.2009.159)
- Kamma-Lorger, C. S. et al. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15 , pp.378-385.
- Samaras, K. et al., 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25 (9), pp.771-775. (10.3928/1081597X-20090813-03)
2008
- Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161 (1), pp.1-8. (10.1016/j.jsb.2007.08.015)
2007
- Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290 (12), pp.1542-1550. (10.1002/ar.20613)
- Hayes, S. et al. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84 (3), pp.423-434. (10.1016/j.exer.2006.10.014)
- Quantock, A. J. et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40 (S1), pp.S335-S340. (10.1107/S0021889807005523)
2006
- Boote, C. et al. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47 (3), pp.901-908. (10.1167/iovs.05-0893)
2005
- Meek, K. M. A. et al. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46 (6), pp.1948-1956. (10.1167/iovs.04-1253)
- Boote, C. et al. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149 (1), pp.1-6. (10.1016/j.jsb.2004.08.009)
- Hayes, S. 2005. Structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus. PhD Thesis , Cardiff University.
2004
- Boote, C. , Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146 (3), pp.359-367. (10.1016/j.jsb.2003.12.009)
2003
- Quantock, A. J. et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44 (5), pp.1906-1911. (10.1167/iovs.02-0884)
- Boote, C. , Hayes, S. and Meek, K. M. A. 2003. Collagen organisation in adult and foetal marmoset cornea. Investigative Ophthalmology and Visual Science 44 (E-Abst)
- Boote, C. et al. 2003. Collagen fibrils appear more closely packed in the prepupilliary cornea: optical and biomechanical implications. Investigative Ophthalmology & Visual Science 44 (7), pp.2941-2948. (10.1167/iovs.03-0131)
- Hayes, S. et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11 , pp.135.
- Hayes, S. , Khan, S. and Meek, K. M. A. 2003. Changes in the refractive index of the cornea when the stroma swells [Abstract]. Investigative Ophthalmology & Visual Science 44 886.
- Meek, K. , Hayes, S. and Khan, S. 2003. Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells. Biophysical Journal 85 (4), pp.2205-2212.
- Meek, K. M. A. et al. 2003. Transparency, swelling and scarring in the corneal stroma. Eye 17 (8), pp.927-936. (10.1038/sj.eye.6700574)
Adrannau llyfrau
- Meek, K. M. et al. 2020. X-ray diffraction imaging of corneal ultrastructure. In: Ahearne, M. ed. Corneal Regeneration: Methods and Protocols. Vol. 2145, Methods in Molecular Biology New York, NY, USA: Humana. , pp.231-247. (10.1007/978-1-0716-0599-8_16)
Erthyglau
- Kollros, L. et al., 2026. Dehydration and rehydration behavior of ultra-high-fluence Extracorporeal Cross-Linked Corneal Allogenic Intrastromal Ring Segments (ECO-CAIRS). Journal of Cataract and Refractive Surgery (10.1097/j.jcrs.0000000000002015)
- Bains, K. K. et al. 2026. The structural order of crystallin proteins during early human lens development. Investigative Ophthalmology & Visual Science 67 (1) 50. (10.1167/iovs.67.1.50)
- Borgia, A. et al., 2026. Corneal stromal thinning and posterior irregularity after DMEK: Clinical observations and biophysical hypotheses. Cornea: The Journal of Cornea and External Disease (10.1097/ico.0000000000004084)
- Wang, X. et al. 2025. The correlation between myopia severity and stress-strain index (SSI) using the Corneal Visualization Scheimpflug Technology (Corvis ST). Scientific Reports 15 (1) 40103. (10.1038/s41598-025-23834-x)
- Bell, J. et al. 2025. Hierarchical biomechanical characterisation of riboflavin-UVA crosslinking and decorin treatment in the porcine cornea. Frontiers in Bioengineering and Biotechnology 13 1603679. (10.3389/fbioe.2025.1603679)
- Wang, X. et al. 2025. Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies. Eye and Vision 12 (1) 18. (10.1186/s40662-025-00435-3)
- Meek, K. M. et al. 2025. Structural control of corneal transparency, refractive power and dynamics. Eye 39 , pp.644-650. (10.1038/s41433-024-02969-7)
- Yang, M. et al., 2024. Development of graphitic carbon nitride quantum dots-based oxygen self-sufficient platforms for enhanced corneal crosslinking. Nature Communications 15 5508. (10.1038/s41467-024-49645-8)
- Morgan, S. R. et al. 2024. An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking. Eye and Vision 11 (8)(10.1186/s40662-024-00375-4)
- Hayes, S. et al. 2023. National survey of corneal cross-linking (CXL) practice patterns in the United Kingdom during 2019. Eye 37 , pp.2511-2517. (10.1038/s41433-022-02365-z)
- Gao, R. et al., 2022. The impact of different rose bengal formulations on corneal thickness and the efficacy of rose bengal/green light corneal cross-linking in the rabbit eye. Journal of Refractive Surgery 38 (7), pp.450-458. (10.3928/1081597X-20220601-03)
- Bell, J. et al. 2022. The hierarchical response of human corneal collagen to controlled inflation. Investigative Ophthalmology & Visual Science 63 (7) 2392 – A0195.
- Bell, J. S. et al. 2022. Tropocollagen springs allow collagen fibrils to stretch elastically. Acta Biomaterialia 142 , pp.185-193. (10.1016/j.actbio.2022.01.041)
- Zhou, D. et al., 2021. Fibril density reduction in keratoconic corneas. Journal of the Royal Society Interface 18 (175) 20200900. (10.1098/rsif.2020.0900)
- Hayes, S. , Morgan, S. R. and Meek, K. M. 2021. Keratoconus: cross-linking the window of the eye. Therapeutic Advances in Rare Disease 2 , pp.1-14. (10.1177/26330040211003573)
- Hayes, S. et al. 2020. The effect of bacteriochlorophyll derivative WST-D and near infrared light on the molecular and fibrillar architecture of the corneal stroma. Scientific Reports 10 9836. (10.1038/s41598-020-66869-y)
- Feneck, E. M. et al. 2020. Developmental abnormalities in the cornea of a mouse model for Marfan syndrome. Experimental Eye Research 194 108001. (10.1016/j.exer.2020.108001)
- Morgan, S. et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8 13742. (10.1038/s41598-018-32110-0)
- Bell, J. et al. 2018. A subfibrillar deformation mechanism in corneal collagen that affords flexibility [Abstract]. Investigative Ophthalmology & Visual Science 59 (9) 1415.
- Hayes, S. , Meek, K. and Mukherjee, A. 2018. Use of donors predisposed by corneal collagen cross-linking in penetrating keratoplasty for treating patients with keratoconus. American Journal of Ophthalmology 188 , pp.181-181. (10.1016/j.ajo.2017.12.026)
- Pinsky, P. M. et al., 2018. A simple mathematical model for collagen fibril organization in normal and keratoconic corneas. Journal for Modeling in Ophthalmology 1
- O'Brart, N. et al., 2018. An investigation of the effects of riboflavin concentration on the efficacy of corneal cross-linking using an enzymatic resistance model in porcine corneas. Investigative Ophthalmology and Visual Science 59 , pp.1058-1065. (10.1167/iovs.17-22994)
- Bell, J. S. et al. 2018. The hierarchical response of human corneal collagen to load. Acta Biomaterialia 65 , pp.216-225. (10.1016/j.actbio.2017.11.015)
- Islam, M. M. et al., 2018. Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation. npj Regenerative Medicine 3 2. (10.1038/s41536-017-0038-8)
- O’Brart, D. P. S. et al., 2018. The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking. Investigative Ophthalmology and Visual Science 59 , pp.4449-4450. (10.1167/iovs.18-24437)
- Abass, A. et al., 2017. SAXS4COLL: an integrated software tool for analysing fibrous collagen-based tissues. Journal of Applied Crystallography 50 , pp.1235-1240. (10.1107/S1600576717007877)
- Hayes, S. et al. 2017. The structural response of the cornea to changes in stromal hydration. Interface 14 (131)(10.1098/rsif.2017.0062)
- White, T. et al. 2017. The structural role of elastic fibres in the cornea investigated using a mouse model for Marfan syndrome. Investigative Ophthalmology and Vision Science 58 (4), pp.2106-2116. (10.1167/iovs.16-21358)
- Aldahlawi, N. H. et al. 2016. An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols. Experimental Eye Research 153 , pp.141-151. (10.1016/j.exer.2016.10.014)
- Aldahlawi, N. H. et al. 2016. Enzymatic resistance of corneas crosslinked using riboflavin in conjunction with low energy, high energy, and pulsed UVA irradiation modes. Investigative Ophthalmology & Visual Science 57 (4), pp.1547-1552. (10.1167/iovs.15-18769)
- Hayes, S. et al. 2015. The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia 25 , pp.121-130. (10.1016/j.actbio.2015.07.009)
- Hayes, S. et al. 2015. A study of stromal riboflavin absorption inex vivoporcine corneas using new and existing delivery protocols for corneal cross-linking. Acta Ophthalmologica 94 (2), pp.e109-e117. (10.1111/aos.12884)
- Mukherjee, A. et al., 2015. Donor cross-linking for keratoplasty: a laboratory evaluation. Graefe's Archive for Clinical and Experimental Ophthalmology 252 (12), pp.2223-2228. (10.1007/s00417-015-3160-6)
- Aldahlawi, N. et al. 2015. Standard versus accelerated riboflavin/ultraviolet corneal cross-linking: Resistance against enzymatic digestion. Journal of Cataract and Refractive Surgery 41 (9), pp.1989-1996. (10.1016/j.jcrs.2015.10.004)
- Abass, A. et al. 2015. Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society Interface 12 (104) 20140717. (10.1098/rsif.2014.0717)
- Davidson, A. E. et al., 2013. The pathogenesis of keratoconus. Eye 28 (2), pp.189-195. (10.1038/eye.2013.278)
- Abahussin, M. et al., 2013. A microscopy study of the structural features of post-LASIK human corneas. PLoS ONE 8 (5) e63268. (10.1371/journal.pone.0063268)
- Hayes, S. et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8 (1) e52860. (10.1371/journal.pone.0052860)
- Boote, C. et al. 2013. Quantification of Collagen Ultrastructure after Penetrating Keratoplasty - Implications for Corneal Biomechanics. PLoS ONE 8 (7) e68166. (10.1371/journal.pone.0068166)
- Meek, K. M. A. and Hayes, S. 2013. Corneal crosslinking - A review. Ophthalmic and Physiological Optics 33 (2), pp.78-93. (10.1111/opo.12032)
- Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53 (6), pp.2786-2795. (10.1167/iovs.11-9305)
- Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130 (2), pp.251-252. (10.1001/archopthalmol.2011.1467)
- Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101 (1), pp.33-42. (10.1016/j.bpj.2011.05.029)
- Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6 (8) e22405. (10.1371/journal.pone.0022405)
- Hayes, S. et al. 2011. The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. Molecular Vision 17 , pp.3107-3115.
- Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169 (3), pp.424-430. (10.1016/j.jsb.2009.11.004)
- Sheppard, J. et al. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51 (6), pp.2936-2942. (10.1167/iovs.09-4612)
- Kamma-Lorger, C. S. et al. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88 (5), pp.953-959. (10.1016/j.exer.2008.12.005)
- Abahussin, M. O. et al. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50 (11), pp.5159-5164. (10.1167/iovs.09-3669)
- Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166 (2), pp.195-204. (10.1016/j.jsb.2009.01.009)
- Hayes, S. et al. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24 (4), pp.728-734. (10.1038/eye.2009.159)
- Kamma-Lorger, C. S. et al. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15 , pp.378-385.
- Samaras, K. et al., 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25 (9), pp.771-775. (10.3928/1081597X-20090813-03)
- Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161 (1), pp.1-8. (10.1016/j.jsb.2007.08.015)
- Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290 (12), pp.1542-1550. (10.1002/ar.20613)
- Hayes, S. et al. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84 (3), pp.423-434. (10.1016/j.exer.2006.10.014)
- Quantock, A. J. et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40 (S1), pp.S335-S340. (10.1107/S0021889807005523)
- Boote, C. et al. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47 (3), pp.901-908. (10.1167/iovs.05-0893)
- Meek, K. M. A. et al. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46 (6), pp.1948-1956. (10.1167/iovs.04-1253)
- Boote, C. et al. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149 (1), pp.1-6. (10.1016/j.jsb.2004.08.009)
- Boote, C. , Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146 (3), pp.359-367. (10.1016/j.jsb.2003.12.009)
- Quantock, A. J. et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44 (5), pp.1906-1911. (10.1167/iovs.02-0884)
- Boote, C. , Hayes, S. and Meek, K. M. A. 2003. Collagen organisation in adult and foetal marmoset cornea. Investigative Ophthalmology and Visual Science 44 (E-Abst)
- Boote, C. et al. 2003. Collagen fibrils appear more closely packed in the prepupilliary cornea: optical and biomechanical implications. Investigative Ophthalmology & Visual Science 44 (7), pp.2941-2948. (10.1167/iovs.03-0131)
- Hayes, S. et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11 , pp.135.
- Hayes, S. , Khan, S. and Meek, K. M. A. 2003. Changes in the refractive index of the cornea when the stroma swells [Abstract]. Investigative Ophthalmology & Visual Science 44 886.
- Meek, K. , Hayes, S. and Khan, S. 2003. Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells. Biophysical Journal 85 (4), pp.2205-2212.
- Meek, K. M. A. et al. 2003. Transparency, swelling and scarring in the corneal stroma. Eye 17 (8), pp.927-936. (10.1038/sj.eye.6700574)
Gosodiad
- Hayes, S. 2005. Structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus. PhD Thesis , Cardiff University.
Ymchwil
My current research is aimed at further understanding the relationship between structure and function in normal and diseased corneas. I am particularly interested in keratoconus, a disease characterised by progressive thinning and steepening of the cornea and severe irregular astigmatism. Keratoconus is one of the leading causes of corneal transplant surgery in the UK.
During my doctoral studies I used a combination of videokeratography to assess corneal shape, and synchrotron x-ray diffraction to gain quantitative structural information about the organisation and distribution of collagen in normal and keratoconus corneas, to examine the link between corneal structure and specific keratoconus shape changes. The findings of this study supported the theory that lamellar slippage is involved in the progressive thinning and steepening of keratoconus corneas. In recent years a therapeutic treatment has been developed to strenghten corneal tissue and halt the progressive steepening of keratoconus corneas. The treatment involves the combined use of UVA and riboflavin to stabilise corneal collagen and its surrounding matrix. I am currently investigating the mechanism by which the treatment strengthens the cornea and the ways in which the treatment can be modified to minimise patient treatment time and maximise patient comfort.
I am also interested in human corneal development, in particular the structural changes that lead to the cornea becoming strong, transparent and precisely curved. Recently granted access to the MRC/Wellcome Trust-funded Human Developmental Biology Resource (HDBR) has provided a unique opportunity to examine structural changes occurring at key stages of foetal development.
Recent Research Seminars
2016 Invited speaker at the CXL Experts meeting, Zurich, Switzerland
2015 Invited speaker at the 11th International Congress on Corneal Cross-linking, Boston, USA
2015 ARVO, Denver, USA
2012 8th International Congress on Corneal Cross-linking, Geneva, Switzerland
2012 XIVth Bowmans Club Annual meeting, Newcastle, UK
Addysgu
- Goruchwylio myfyrwyr PhD/MPhil
- Gweithgareddau ymgysylltu STEM mewn ysgolion lleol fel rhan o'r Rhaglen Llysgenhadon STEM
Bywgraffiad
Addysg
2001-2005: PhD Bioffiseg Strwythurol: Trefniadaeth strwythurol colagen yn gornbilennau primatiaid a mamaliaid eraill a'r newidiadau stromal sy'n gysylltiedig â'r clefyd keratoconws. Grŵp Bioffiseg Strwythurol, Ysgol Optometreg a Gwyddorau Gweledigaeth, Prifysgol Caerdydd.
1997 - 2000: Anrhydedd Dosbarth Cyntaf mewn Gwyddor Anifeiliaid/Ceffylau Prifysgol Aberystwyth
Hanes gyrfa
2025-presennol: Uwch Gymrawd Ymchwil/Hwylusydd Ymchwil. Ysgol Optometreg a Gwyddorau'r Golwg, Prifysgol Caerdydd.
2025-presennol: Cynorthwy-Grantiau. Swyddfa Ariannu Grant Taith, Caerdydd
2019-2025: Cyd-Ymchwilydd / Uwch Gymrawd Ymchwil ar Grant 5 mlynedd o £2.4 miliwn o'r Cyngor Ymchwil Feddygol: Dealltwriaeth fecanyddol o pathobioleg y gornbilen a datblygu strategaethau therapiwtig newydd ar gyfer trin anhwylderau meinwe gyswllt. Grŵp Bioffiseg Strwythurol, Ysgol Optometreg a Gwyddorau'r Golwg, Prifysgol Caerdydd
2018-2019: Cymrawd Ymchwil/Hwylusydd Ymchwil a Chynrychiolydd Ymgysylltu â'r Cyhoedd (a ariennir gan yr Ysgol): Ysgol Optometreg a Gwyddorau'r Golwg, Prifysgol Caerdydd
2005 - 2018: Cymrawd Ymchwil / Cydymaith Ymchwil ar ddau Grant y Cyngor Ymchwil Feddygol: (1) Y matrics colagen mewn patholeg cornbilen, ac effaith therapïau newydd ar gyfer colli tryloywder a statws plygiannol; (2) Sail uwchstrwythurol camweithrediad cornbilen a datblygu ac optimeiddio therapïau newydd. Grŵp Bioffiseg Strwythurol, Ysgol Optometreg a Gwyddorau'r Golwg, Prifysgol Caerdydd
2001-2005: Cynorthwy-ydd Ymchwil ar Grant Clouncil Ymchwil Feddygol 5 mlynedd: Tryloywder Corneal, Pŵer Dioptric a'u Newidiadau mewn Cyflyrau Patholegol. Grŵp Bioffiseg Strwythurol, Ysgol Optometreg a Gwyddorau'r Golwg, Prifysgol Caerdydd
Anrhydeddau a dyfarniadau
Finalist in the Royal Institute Science Graduate of the Year Award, 2004
Cardiff University outstanding contribution award, 2014
Aelodaethau proffesiynol
- Cymrawd y Gymdeithas Frenhinol Bioleg, 2016-2025
Ymrwymiadau siarad cyhoeddus
Cyflwyniadau gwahoddedig
Mehefin 2024 Cadeirydd Sesiwn CXL y DU yng Nghyngres Flynyddol BSRS, Rhydychen.
Chwefror 2023 Siaradwr gwahoddedig yn yr Uwchgynhadledd Croesgysylltu Keratoconws a Chornbilen Ryngwladol (darlith westai rithwir 15 munud, Prifysgol Fudan, Shanghai, Tsieina).
Hydref 2022 Siaradwr gwadd yng nghyfarfod UKICRS (darlith wadd 15 munud, Hinchley, DU)
Hydref 2022 Siaradwr gwadd yng Nghynhadledd Cymdeithas Hunangymorth a Chefnogaeth Keratoconus y DU (darlith westai 30 munud, Llundain, y DU)
Hydref 2022 Siaradwr gwadd yng nghyfarfod Addysgu Ôl-raddedig Rhanbarthol Prifysgol Newcastle (darlith westai 45 munud)
2019 Siaradwr gwadd yng Nghyfarfod Cymdeithas Offthalmoleg y De-orllewin (darlith westai 40 munud, Bryste, y DU)
2016/17/18 Siaradwr gwadd yngnghyfarfod Arbenigwyr Trawsgysylltu rhyngwladol (2016, 2017 a 2018, Zurich, y Swistir)
2015 Siaradwr gwaddedig yn yr 11eg Gyngres Ryngwladol Croes-gysylltu Corneal (Boston, UDA).
Pwyllgorau ac adolygu
Aelodau'r Pwyllgor
- Aelod o'r Pwyllgor Ymchwil Ysgol (2014-2016 a 2018-presennol)
- Aelod o Bwyllgor Ysgol Athena Swan (2024-2025; Gwobr Arian wedi'i Ennill)
- Aelod o Bwyllgor Llywio Consortiwm Trawsgysylltu'r DU (2013-2025)
- Aelod o'r panel ar gyfer Cronfa Ymgysylltu â'r Cyhoedd ISSF Ymddiriedolaeth Wellcome (2019-2021)
- Aelod o Weithgor Rhwydwaith Ymgysylltu â'r Cyhoedd y Coleg (2019-2020)
- Aelod o Bwyllgor Ymgysylltu â'r Cyhoedd Sefydliad Peirianneg a Thrwsio Meinweoedd Caerdydd (2019-2020)
- Aelod o'r Grŵp Blaenoriaethu Ymchwil COVID-19 (Mawrth-Tachwedd 2020)
- Aelod o Bwyllgor Athena Swan yr Ysgol, ennill gwobr Efydd (2017-2019)
- Aelod cyfadran o Gyfarfod Arbenigwyr CXL Rhyngwladol (2017-2018)
- Aelod o'r Pwyllgor Moeseg Ysgolion (2016-2019)
Cyrff cyllido grant a chyfnodolion gwyddonol:
- Adolygydd allanol gwahoddedig ar gyfer cyllid DPFS MRC UKRI (2025)
- Adolygydd cymheiriaid ar gyfer Rhaglen Ariannu Cyfrif Cyflymu Effaith UKRI (2023-2025)
- Adolygydd allanol gwahoddedig am gyllid gan y Ganolfan Wyddoniaeth Genedlaethol, Gwlad Pwyl (2022)
- Adolygydd arbenigol allanol ar gyfer asesiad Technoleg Iechyd Cymru o gost-effeithiolrwydd trawsgysylltu cornbilen (a gynhaliwyd ar ran Llywodraeth Cynulliad Cymru) (2020-2021)
- Adolygydd cymheiriaid ar gyfer sawl cyfnodolyn gwyddonol gan gynnwys Vision Science (2024), Ocular Surface (2023), Nature Communications (2023), Journal of Cataract and Refrcative Surgery (2022), Frontiers in Pharmacology (2021), Investigative Ophthalmology and Vision Sciences (2020), BMC Notes (2020), Current Eye Research (2019), a Journal of Refractive Surgery (2018).
- Aelod o Fwrdd Golygyddol Adroddiadau Gwyddonol, Grŵp Cyhoeddi Natur (2018-2019)
Arholwr PhD allanol penodedig
- Arholwr PhD allanol ym Mhrifysgol Manceinion (2018 a 2021), a Phrifysgol Lerpwl (2019)
Meysydd goruchwyliaeth
- Strwythur/swyddogaeth corneal, patholeg a therapïau newydd
Goruchwyliaeth gyfredol
Leonard Kollros
Prosiectau'r gorffennol
-
Nada Aldahlawi: Asesiad o ddulliau therapiwtig newydd sy'n anelu at stiffening y gornbilen. Traethawd PhD, Prifysgol Caerdydd, 2018
-
Siân Morgan, Deall sail strwythurol swyddogaeth plygiannol y gornbilen a'i addasu trwy ddulliau therapiwtig newydd. Traethawd PhD, Prifysgol Caerdydd, 2014
Contact Details
+44 29208 70459
Optometreg a Gwyddorau'r Golwg , Ystafell Ystafell 3.22, Heol Maendy, Cathays, Caerdydd, CF24 4HQ