Dr Sally Hayes

Articles

• Yang, M. et al. 2024. Development of graphitic carbon nitride quantum dots-based oxygen self-sufficient platforms for enhanced corneal crosslinking. Nature Communications 15, article number: 5508. (10.1038/s41467-024-49645-8)
• Morgan, S. R., O'Brart, D. P. S., Huang, J., Meek, K. M. and Hayes, S. 2024. An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking. Eye and Vision 11(8) (10.1186/s40662-024-00375-4)
• Meek, K. M., Knupp, C., Lewis, P. N., Morgan, S. R. and Hayes, S. 2024. Structural control of corneal transparency, refractive power and dynamics. Eye (10.1038/s41433-024-02969-7)
• Hayes, S., Jaycock, P., Rees, N., Figuerio, F., O'Brart, D. and Meek, K. 2023. National survey of corneal cross-linking (CXL) practice patterns in the United Kingdom during 2019. Eye 37, pp. 2511-2517. (10.1038/s41433-022-02365-z)
• Gao, R. et al. 2022. The impact of different rose bengal formulations on corneal thickness and the efficacy of rose bengal/green light corneal cross-linking in the rabbit eye. Journal of Refractive Surgery 38(7), pp. 450-458. (10.3928/1081597X-20220601-03)
• Bell, J. S. et al. 2022. Tropocollagen springs allow collagen fibrils to stretch elastically. Acta Biomaterialia 142, pp. 185-193. (10.1016/j.actbio.2022.01.041)
• Zhou, D. et al. 2021. Fibril density reduction in keratoconic corneas. Journal of the Royal Society Interface 18(175), article number: 20200900. (10.1098/rsif.2020.0900)
• Hayes, S., Morgan, S. R. and Meek, K. M. 2021. Keratoconus: cross-linking the window of the eye. Therapeutic Advances in Rare Disease 2, pp. 1-14. (10.1177/26330040211003573)
• Hayes, S. et al. 2020. The effect of bacteriochlorophyll derivative WST-D and near infrared light on the molecular and fibrillar architecture of the corneal stroma. Scientific Reports 10, article number: 9836. (10.1038/s41598-020-66869-y)
• Feneck, E. M., Souza, R. B., Lewis, P. N., Hayes, S., Pereira, L. V. and Meek, K. M. 2020. Developmental abnormalities in the cornea of a mouse model for Marfan syndrome. Experimental Eye Research 194, article number: 108001. (10.1016/j.exer.2020.108001)
• Morgan, S. et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8, article number: 13742. (10.1038/s41598-018-32110-0)
• Hayes, S., Meek, K. and Mukherjee, A. 2018. Use of donors predisposed by corneal collagen cross-linking in penetrating keratoplasty for treating patients with keratoconus. American Journal of Ophthalmology 188, pp. 181-181. (10.1016/j.ajo.2017.12.026)
• Pinsky, P. M., Ma, Y., Hwang, Y., Hayes, S. and Meek, K. M. 2018. A simple mathematical model for collagen fibril organization in normal and keratoconic corneas. Journal for Modeling in Ophthalmology 1
• O'Brart, N., O'Brart, D., Aldahlawi, N., Hayes, S. and Meek, K. 2018. An investigation of the effects of riboflavin concentration on the efficacy of corneal cross-linking using an enzymatic resistance model in porcine corneas. Investigative Ophthalmology and Visual Science 59, pp. 1058-1065. (10.1167/iovs.17-22994)
• Bell, J. S. et al. 2018. The hierarchical response of human corneal collagen to load. Acta Biomaterialia 65, pp. 216-225. (10.1016/j.actbio.2017.11.015)
• Islam, M. M. et al. 2018. Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation. npj Regenerative Medicine 3, article number: 2. (10.1038/s41536-017-0038-8)
• O’Brart, D. P. S., O’Brart, N. A. L., Aldahlawi, N., Hayes, S. and Meek, K. 2018. The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking. Investigative Ophthalmology and Visual Science 59, pp. 4449-4450. (10.1167/iovs.18-24437)
• Abass, A., Bell, J. S., Spang, M. T., Hayes, S., Meek, K. M. A. and Boote, C. 2017. SAXS4COLL: an integrated software tool for analysing fibrous collagen-based tissues. Journal of Applied Crystallography 50, pp. 1235-1240. (10.1107/S1600576717007877)
• Hayes, S. et al. 2017. The structural response of the cornea to changes in stromal hydration. Interface 14(131) (10.1098/rsif.2017.0062)
• White, T. et al. 2017. The structural role of elastic fibres in the cornea investigated using a mouse model for Marfan syndrome. Investigative Ophthalmology and Vision Science 58(4), pp. 2106-2116. (10.1167/iovs.16-21358)
• Aldahlawi, N. H., Hayes, S., O'Brart, D. P., O'Brart, N. and Meek, K. M. A. 2016. An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols. Experimental Eye Research 153, pp. 141-151. (10.1016/j.exer.2016.10.014)
• Aldahlawi, N. H., Hayes, S., O'Brart, D. P. S., Akhbanbetova, A., Littlechild, S. L. and Meek, K. M. A. 2016. Enzymatic resistance of corneas crosslinked using riboflavin in conjunction with low energy, high energy, and pulsed UVA irradiation modes. Investigative Ophthalmology & Visual Science 57(4), pp. 1547-1552. (10.1167/iovs.15-18769)
• Hayes, S. et al. 2015. The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia 25, pp. 121-130. (10.1016/j.actbio.2015.07.009)
• Hayes, S., Morgan, S. R., O'Brart, D. P., O'Brart, N. and Meek, K. M. A. 2015. A study of stromal riboflavin absorption inex vivoporcine corneas using new and existing delivery protocols for corneal cross-linking. Acta Ophthalmologica 94(2), pp. e109-e117. (10.1111/aos.12884)
• Mukherjee, A., Hayes, S., Aslanides, I., Lanchares, E. and Meek, K. M. 2015. Donor cross-linking for keratoplasty: a laboratory evaluation. Graefe's Archive for Clinical and Experimental Ophthalmology 252(12), pp. 2223-2228. (10.1007/s00417-015-3160-6)
• Aldahlawi, N., Hayes, S., OBrart, D. and Meek, K. M. A. 2015. Standard versus accelerated riboflavin/ultraviolet corneal cross-linking: Resistance against enzymatic digestion. Journal of Cataract and Refractive Surgery 41(9), pp. 1989-1996. (10.1016/j.jcrs.2015.10.004)
• Abass, A., Hayes, S., White, N., Sorensen, T. and Meek, K. M. 2015. Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society Interface 12(104), article number: 20140717. (10.1098/rsif.2014.0717)
• Davidson, A. E., Hayes, S., Hardcastle, A. J. and Tuft, S. J. 2013. The pathogenesis of keratoconus. Eye 28(2), pp. 189-195. (10.1038/eye.2013.278)
• Boote, C. et al. 2013. Quantification of Collagen Ultrastructure after Penetrating Keratoplasty - Implications for Corneal Biomechanics. PLoS ONE 8(7), article number: e68166. (10.1371/journal.pone.0068166)
• Abahussin, M., Hayes, S., Edelhauser, H., Dawson, D. G. and Meek, K. M. A. 2013. A microscopy study of the structural features of post-LASIK human corneas. PLoS ONE 8(5), article number: e63268. (10.1371/journal.pone.0063268)
• Meek, K. M. A. and Hayes, S. 2013. Corneal crosslinking - A review. Ophthalmic and Physiological Optics 33(2), pp. 78-93. (10.1111/opo.12032)
• Hayes, S. et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8(1), article number: e52860. (10.1371/journal.pone.0052860)
• Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53(6), pp. 2786-2795. (10.1167/iovs.11-9305)
• Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130(2), pp. 251-252. (10.1001/archopthalmol.2011.1467)
• Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101(1), pp. 33-42. (10.1016/j.bpj.2011.05.029)
• Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
• Hayes, S. et al. 2011. The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. Molecular Vision 17, pp. 3107-3115.
• Sheppard, J., Hayes, S., Boote, C., Votruba, M. and Meek, K. M. A. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51(6), pp. 2936-2942. (10.1167/iovs.09-4612)
• Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)
• Abahussin, M. O., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J. and Meek, K. M. A. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50(11), pp. 5159-5164. (10.1167/iovs.09-3669)
• Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166(2), pp. 195-204. (10.1016/j.jsb.2009.01.009)
• Kamma-Lorger, C. S., Boote, C., Hayes, S., Albon, J., Boulton, M. E. and Meek, K. M. A. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88(5), pp. 953-959. (10.1016/j.exer.2008.12.005)
• Samaras, K., O'Brart, D. P., Doutch, J., Hayes, S., Marshall, J. and Meek, K. M. A. 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25(9), pp. 771-775. (10.3928/1081597X-20090813-03)
• Hayes, S., Young, R. D., Boote, C., Hawksworth, N., Huang, Y. and Meek, K. M. A. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24(4), pp. 728-734. (10.1038/eye.2009.159)
• Kamma-Lorger, C. S., Hayes, S., Boote, C., Burghammer, M., Boulton, M. E. and Meek, K. M. A. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15, pp. 378-385.
• Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)
• Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
• Hayes, S., Boote, C., Tuft, S. J., Quantock, A. J. and Meek, K. M. A. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
• Quantock, A. J. et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40(S1), pp. S335-S340. (10.1107/S0021889807005523)
• Boote, C., Hayes, S., Abahussin, M. and Meek, K. M. A. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47(3), pp. 901-908. (10.1167/iovs.05-0893)
• Meek, K. M. A., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R. H. and Bron, A. J. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46(6), pp. 1948-1956. (10.1167/iovs.04-1253)
• Boote, C., Hayes, S., Huang, Y., Quantock, A. J. and Meek, K. M. A. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)
• Boote, C., Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146(3), pp. 359-367. (10.1016/j.jsb.2003.12.009)
• Hayes, S. et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11, pp. 135.
• Quantock, A. J. et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44(5), pp. 1906-1911. (10.1167/iovs.02-0884)
• Boote, C., Hayes, S., Newton, R. H., Puri, H. and Meek, K. M. A. 2003. Collagen fibrils appear more closely packed in the prepupilliary cornea: optical and biomechanical implications. Investigative Ophthalmology & Visual Science 44(7), pp. 2941-2948. (10.1167/iovs.03-0131)
• Meek, K. M. A., Leonard, D., Connon, C. J., Hayes, S. and Khan, S. 2003. Transparency, swelling and scarring in the corneal stroma. Eye 17(8), pp. 927-936. (10.1038/sj.eye.6700574)
• Meek, K., Hayes, S. and Khan, S. 2003. Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells. Biophysical Journal 85(4), pp. 2205-2212.
• Hayes, S., Khan, S. and Meek, K. M. A. 2003. Changes in the refractive index of the cornea when the stroma swells [Abstract]. Investigative Ophthalmology & Visual Science 44, article number: 886.
• Boote, C., Hayes, S. and Meek, K. M. A. 2003. Collagen organisation in adult and foetal marmoset cornea. Investigative Ophthalmology and Visual Science 44(E-Abst)

Book sections

• Meek, K. M., Quantock, A. J., Hayes, S. and Bell, J. 2020. X-ray diffraction imaging of corneal ultrastructure. In: Ahearne, M. ed. Corneal Regeneration: Methods and Protocols., Vol. 2145. Methods in Molecular Biology New York, NY, USA: Humana, pp. 231-247., (10.1007/978-1-0716-0599-8_16)

Conferences

• Bell, J., Morgan, S., Koudouna, E., Hayes, S. and Meek, K. 2022. The hierarchical response of human corneal collagen to controlled inflation. Presented at: 2022 ARVO Annual Meeting, Denver, CO, USA, 1-4 May 2022, Vol. 63. Vol. 7. IOVS pp. 2392.
• Bell, J. et al. 2018. A subfibrillar deformation mechanism in corneal collagen that affords flexibility. Presented at: ARVO Annual Meeting 2018, Honolulu, April 29 - May 3, 2018, Vol. 59. Vol. 9. Association for Research in Vision and Ophthalmology

Thesis

• Hayes, S. 2005. Structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus. PhD Thesis, Cardiff University.

• Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53(6), pp. 2786-2795. (10.1167/iovs.11-9305)
• Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130(2), pp. 251-252. (10.1001/archopthalmol.2011.1467)
• Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101(1), pp. 33-42. (10.1016/j.bpj.2011.05.029)
• Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
• Sheppard, J., Hayes, S., Boote, C., Votruba, M. and Meek, K. M. A. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51(6), pp. 2936-2942. (10.1167/iovs.09-4612)
• Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)
• Abahussin, M. O., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J. and Meek, K. M. A. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50(11), pp. 5159-5164. (10.1167/iovs.09-3669)
• Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166(2), pp. 195-204. (10.1016/j.jsb.2009.01.009)
• Kamma-Lorger, C. S., Boote, C., Hayes, S., Albon, J., Boulton, M. E. and Meek, K. M. A. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88(5), pp. 953-959. (10.1016/j.exer.2008.12.005)
• Samaras, K., O'Brart, D. P., Doutch, J., Hayes, S., Marshall, J. and Meek, K. M. A. 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25(9), pp. 771-775. (10.3928/1081597X-20090813-03)
• Hayes, S., Young, R. D., Boote, C., Hawksworth, N., Huang, Y. and Meek, K. M. A. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24(4), pp. 728-734. (10.1038/eye.2009.159)
• Kamma-Lorger, C. S., Hayes, S., Boote, C., Burghammer, M., Boulton, M. E. and Meek, K. M. A. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15, pp. 378-385.
• Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)
• Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
• Hayes, S., Boote, C., Tuft, S. J., Quantock, A. J. and Meek, K. M. A. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
• Boote, C., Hayes, S., Abahussin, M. and Meek, K. M. A. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47(3), pp. 901-908. (10.1167/iovs.05-0893)
• Meek, K. M. A., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R. H. and Bron, A. J. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46(6), pp. 1948-1956. (10.1167/iovs.04-1253)
• Boote, C., Hayes, S., Huang, Y., Quantock, A. J. and Meek, K. M. A. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)
• Boote, C., Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146(3), pp. 359-367. (10.1016/j.jsb.2003.12.009)