![Trevor Humby BSc (Hons) Sussex, PhD Cambridge](https://profiles-cardiff.imgix.net/attachments/2997?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Trevor Humby
BSc (Hons) Sussex, PhD Cambridge
Darllenydd
- HumbyT@caerdydd.ac.uk
- +44 29208 76758
- Adeilad y Tŵr, Plas y Parc, Caerdydd, CF10 3AT
Trosolwyg
Crynodeb ymchwil
Mae fy niddordebau ymchwil, fel rhan o'r Grŵp Geneteg Ymddygiadol, yn canolbwyntio ar effeithiau genynnau argraffedig a newidiadau epigenetig ar ddatblygiad yr ymennydd a'r effaith hirdymor ar wybyddiaeth, ymddygiad a datblygiad a swyddogaeth niwronau sylfaenol. Mae mewnargraffu genetig yn cyfeirio at farcio penodol 'rhiant tarddiad' genyn, lle gellir mynegi neu ail-greu alel yn dibynnu a yw'n deillio o'r germline mamol neu'r tadol. Mae'r ymadrodd/gormes hwn yn cael ei reoli gan farcwyr epigenetig (e.e. methylation ac acetylation o histones) sy'n llywodraethu ac yn ffurfweddu sut mae genyn yn cael ei fynegi ac yn gallu gweithredu felly. Mae genynnau heb eu hargraffu yn hanfodol bwysig yn ystod datblygiad cynnar yn y groth ac effaith ar swyddogaeth brychol, rheoli gofynion maethol y ffetws a / neu ofynion y ffetws ar y fam. Mae camweithrediad genynnau sydd wedi'u hargraffu, trwy fynegiant o enyn sydd wedi'i ail-wasgu'n 'normal' neu o dan fynegiant o enyn a fynegir ' fel arfer', yn arwain at nifer o gyflyrau clinigol fel Syndrom Beckwith-Weidemann, Syndrom Prader-Willi , Angelman a gall fod yn cyfrannu at gyflyrau clinigol eraill fel ADHD, OCD, awtistiaeth a sgitsoffrenia
Mae diddordebau ymchwil eraill yn cael eu cyfeirio at ddeall y materion genetig sy'n sail i swyddogaeth yr ymennydd, yn fwyaf nodedig o ran afiechydon fel Alzheimer, FTDP-17 ac ADHD. Mae dementia fronto-temporal gyda Parkinson sy'n gysylltiedig â chromosom 17 (FTDP-17) yn fath o ddementia sy'n effeithio ar bron gymaint o bobl â chlefyd Alzheimer ac yn rhannu patholeg debyg ond sy'n arwain at ystod wahanol o problemau gwybyddol ac ymddygiadol. Gan ddefnyddio model llygoden trawsgenig sy'n mynegi genyn dynol sy'n ymgorffori mwtaniad y gwyddys ei fod yn achosi FTDP-17, mae ein gwaith yn y maes hwn yn ymchwilio i'r ystod o broblemau gwybyddol a ganfuwyd a sut maent yn newid gydag oedran ac yna i nodi'r achosion niwrobiolegol sylfaenol.
Am fwy o wybodaeth am y Grŵp Geneteg Ymddygiadol - ewch i http://sites.cardiff.ac.uk/behavioural-genetics/
Mae gen i ddiddordeb hefyd yn rôl camweithrediad gwybyddol mewn dyslecsia - yn fwyaf arbennig namau cof gweithiol, ac wedi cydweithio â Neil Cottrell, a raddiodd yn ddiweddar o'r ysgol ac mae gen i ddiddordeb parhaus mewn rheolaeth ysgogol a gwneud penderfyniadau.
Cyhoeddiad
2024
- Wren, G., Flanagan, J., Underwood, J., Thompson, A., Humby, T. and Davies, W. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior
2023
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60, pp. 636-643. (10.1136/jmg-2022-108862)
2022
- Wren, G., Humby, T., Thompson, A. and Davies, W. 2022. Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis. Clinical and Experimental Dermatology 47(6), pp. 1097-1108. (10.1111/ced.15116)
- Waldron, S. et al. 2022. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 21(4), article number: e12797. (10.1111/gbb.12797)
- Pass, R., Haan, N., Humby, T., Wilkinson, L. S., Hall, J. and Thomas, K. L. 2022. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior 21(4), article number: e12799. (10.1111/gbb.12799)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
2021
- Westacott, L. J. et al. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98, pp. 136-150. (10.1016/j.bbi.2021.08.215)
- Zahova, S., Humby, T., Davies, J., Morgan, J. E. and Isles, A. 2021. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Translational Psychiatry 11, article number: 433. (10.1038/s41398-021-01561-x)
2020
- Dent, C. L., Rienecker, K. D. A., Ward, A., Wilkins, J. F., Humby, T. and Isles, A. R. 2020. Mice lacking paternal expression of imprinted 1 Grb10 are risk-takers. Genes, Brain and Behavior 19(7), article number: e12679. (10.1111/gbb.12679)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237, pp. 1745-1756. (10.1007/s00213-020-05496-x)
2019
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Davies, J. R., Wilkinson, L. S., Isles, A. R. and Humby, T. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28(18), pp. 3013-3023. (10.1093/hmg/ddz100)
- Silva, A. I. et al. 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10, article number: 3455. (10.1038/s41467-019-11119-7)
- Humby, T., Patel, Y., Carter, J., Stokes, L. G., Rogers, R. D. and Wilkinson, L. S. 2019. Feeding behaviour, risk-sensitivity and response control: effects of 5-HT 2C receptor manipulations. Philosophical Transactions B: Biological Sciences 374(1766), article number: 20180144. (10.1098/rstb.2018.0144)
- Isles, A. R., Winstanley, C. A. and Humby, T. 2019. Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications. Philosophical Transactions B: Biological Sciences 374(1766), pp. -., article number: 128. (10.1098/rstb.2018.0128)
- Humby, T. and Davies, W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Translational Neuroscience 10(1), pp. 168-174. (10.1515/tnsci-2019-0030)
2018
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209(1), pp. 233-239. (10.1534/genetics.118.300898)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17(2), pp. 149-157. (10.1111/gbb.12422)
2017
- Humby, T. et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior 7(3), article number: e00646. (10.1002/brb3.646)
2016
- Humby, T., Cross, E. S., Messer, L., Guerrero, S. and Davies, W. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74, pp. 363-370. (10.1016/j.psyneuen.2016.09.019)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15(8), pp. 693-701. (10.1111/gbb.12316)
- Chatterjee, S., Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. PLoS ONE 11(10), pp. e0164417., article number: e0164417. (10.1371/journal.pone.0164417)
2015
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42(4), pp. 2105-2113. (10.1111/ejn.12972)
2014
- Davies, W., Humby, T., Trent, S., Eddy, J. B., Ojarikre, O. A. and Wilkinson, L. S. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39, pp. 2622-2632. (10.1038/npp.2014.115)
- Hiscox, L., Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20(3), pp. 208-224. (10.1002/dys.1480)
- Dent, C., Isles, A. R. and Humby, T. 2014. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience 39(4), pp. 520-530. (10.1111/ejn.12430)
2013
- Humby, T., Eddy, J. B., Good, M. A., Reichelt, A. C. and Wilkinson, L. S. 2013. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology 38(11), pp. 2150-2159. (10.1038/npp.2013.112)
- Reichelt, A. C., Killcross, S., Wilkinson, L. S., Humby, T. and Good, M. A. 2013. Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory 104, pp. 73-81. (10.1016/j.nlm.2013.05.005)
- Kopsida, E., Lynn, P. M., Humby, T., Wilkinson, L. S. and Davies, W. 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8(8), article number: e73699. (10.1371/journal.pone.0073699)
- Trent, S. et al. 2013. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology 38(8), pp. 1370-1380. (10.1016/j.psyneuen.2012.12.002)
- Mikaelsson, M. A., Constância, M., Dent, C., Wilkinson, L. S. and Humby, T. 2013. Placental programming of anxiety in adulthood revealed by lgf2-null models. Nature Communications 4, article number: 2311. (10.1038/ncomms3311)
2012
- Relkovic, D., Humby, T., Hagan, J. J., Wilkinson, L. S. and Isles, A. R. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126(3), pp. 488-492. (10.1037/a0028155)
- Trent, S., Cassano, T., Bedse, G., Ojarikre, O. A., Humby, T. and Davies, W. 2012. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology 37(5), pp. 1267-1274. (10.1038/npp.2011.314)
- Trent, S., Dennehy, A., Richardson, H., Ojarikre, O. A., Burgoyne, P. S., Humby, T. and Davies, W. 2012. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology 37(2), pp. 221-229. (10.1016/j.psyneuen.2011.06.006)
2011
- Humby, T. and Wilkinson, L. S. 2011. Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology 11(5), pp. 534-539. (10.1016/j.coph.2011.06.006)
2010
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31(1), pp. 156-164. (10.1111/j.1460-9568.2009.07048.x)
2009
- Davies, W., Humby, T., Kong, W., Otter, T. L., Burgoyne, P. S. and Wilkinson, L. S. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66(4), pp. 360-367. (10.1016/j.biopsych.2009.01.001)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18(12), pp. 2140-2148. (10.1093/hmg/ddp137)
2008
- Doe, C., Garfield, A., Humby, T., Relkovic, D., Wilkinson, L. S. and Isles, A. R. 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22(s2), pp. 125. (10.1111/j.1472-8206.2008.00601.x)
- Donald, S. et al. 2008. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America 105(11), pp. 4483-4488. (10.1073/pnas.0712324105)
- Davies, W., Isles, A. R., Humby, T. and Wilkinson, L. S. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626. Berlin: Springer, pp. 62-70., (10.1007/978-0-387-77576-0_5)
2007
- Lambourne, S. L., Humby, T., Isles, A. R., Emson, P. C., Spillantini, M. G. and Wilkinson, L. S. 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16(14), pp. 1708-1719. (10.1093/hmg/ddm119)
- Davies, W., Humby, T., Isles, A. R., Burgoyne, P. S. and Wilkinson, L. S. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61(12), pp. 1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W., Isles, A. R., Humby, T. and Wilkinson, L. S. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2(4), pp. 201-206. (10.4161/epi.2.4.5379)
2006
- Colebrooke, R. E., Humby, T., Lynch, P. J., McGowan, D. P., Xia, J. and Emson, P. C. 2006. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. European Journal of Neuroscience 24(9), pp. 2622-2630. (10.1111/j.1460-9568.2006.05143.x)
- Tofaris, G. K. et al. 2006. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience 26(15), pp. 3942-3950. (10.1523/JNEUROSCI.4965-05.2006)
- Isles, A. R. and Humby, T. 2006. Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research 50(5), pp. 318-325. (10.1111/j.1365-2788.2006.00843.x)
- Humby, T. and Wilkinson, L. S. 2006. If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. S. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Contemporary Clinical Neuroscience Totowa, NJ: Humana Press, pp. 69-83., (10.1007/978-1-59745-058-4_4)
2005
- Isles, A. R., Hathway, G. J., Humby, T., de la Riva, C., Kendrick, K. M. and Wilkinson, L. S. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22(4), pp. 997-1000. (10.1111/j.1460-9568.2005.04265.x)
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37(6), pp. 625-629. (10.1038/ng1577)
- Plagge, A. et al. 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25(8), pp. 3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Humby, T., Wilkinson, L. S. and Dawson, G. 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. In: Current Protocols in Neuroscience. Chichester: Wiley, (10.1002/0471142301.ns0805hs31)
2004
- Isles, A. R., Humby, T., Walters, E. and Wilkinson, L. S. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24(30), pp. 6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
2003
- Isles, A. R., Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170(4), pp. 376-382. (10.1007/s00213-003-1551-6)
- Davies, W., Isles, A. R., Burgoyne, P. S., Ward, B. O., Humby, T., de la Riva, C. and Wilkinson, L. S. 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17(S), pp. A70.
2001
- Mooslehner, K. A. et al. 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21(16), pp. 5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
- Caine, S. B., Humby, T., Robbins, T. W. and Everitt, B. J. 2001. Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle. Behavioral Neuroscience 115(4), pp. 880-894. (10.1037/0735-7044.115.4.880)
- Baunez, C., Humby, T., Eagle, D. M., Ryan, L. J., Dunnett, S. B. and Robbins, T. W. 2001. Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience 13(8), pp. 1609-1616. (10.1046/j.0953-816x.2001.01521.x)
2000
- Passetti, F., Humby, T., Everitt, B. J. and Robbins, T. W. 2000. Mixed attentional and executive deficits in medial frontal cortex lesioned rats. Psychobiology 28(2), pp. 261-271.
1999
- Humby, T., Laird, F. M., Davies, W. and Wilkinson, L. S. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11(8), pp. 2813-2823. (10.1046/j.1460-9568.1999.00701.x)
- Eagle, D. M., Humby, T., Dunnett, S. B. and Robbins, T. W. 1999. Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behavioral Neuroscience 113(4), pp. 718-731. (10.1037/0735-7044.113.4.718)
- Eagle, D. M., Humby, T., Howman, M., Reid-Henry, A., Dunnett, S. B. and Robbins, T. W. 1999. Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats. Psychobiology 27(2), pp. 267-276.
- Hall, F. S., Wilkinson, L. S., Humby, T. and Robbins, T. W. 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32(1), pp. 37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)
- Carter, R. J. et al. 1999. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. The Journal of Neuroscience 19(8), pp. 3248-3257.
- French, S. J., Humby, T., Horner, C. H., Sofroniew, M. V. and Rattray, M. 1999. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Molecular Brain Research 67(1), pp. 124-136. (10.1016/S0169-328X(99)00048-0)
1998
- Hall, F. S., Wilkinson, L. S., Humby, T., Inglis, W., Kendall, D. A., Marsden, C. A. and Robbins, T. W. 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59(4), pp. 859-872. (10.1016/S0091-3057(97)00510-8)
- Wilkinson, L. S., Humby, T., Killcross, A. S., Torres, E., Everitt, B. J. and Robbins, T. W. 1998. Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience 10(3), pp. 1019-1026. (10.1046/j.1460-9568.1998.00119.x)
- Eagle, D. M., Humby, T., Robbins, T. W. and Dunnett, S. B. 1998. A progressive ratio study of response to reward following striatal damage [Abstract]. European Journal of Neuroscience 10(S), pp. 418.
- French, S. J., Rattray, M., Humby, T. and Sofronlew, M. 1998. Regulation of hippocampal neurotrophin gene expression by sub-toxic and behaviourally inactive doses of glutamatergic and cholinergic agonists [Abstract]. European Journal of Neuroscience 10(S), pp. 116.
1997
- Brasted, P. J., Humby, T., Dunnett, S. B. and Robbins, T. W. 1997. Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. The Journal of Neuroscience 17(22), pp. 8919-8926.
- Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. 1997. The effects of isolation-rearing on preference by rats for a novel environment. Physiology & Behavior 62(2), pp. 299-303. (10.1016/S0031-9384(97)00117-0)
- Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. 1997. The effects of isolation-rearing on sucrose consumption in rats. Physiology & Behavior 62(2), pp. 291-297. (10.1016/S0031-9384(97)00116-9)
- Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. 1997. The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior 62(2), pp. 281-290. (10.1016/S0031-9384(97)00115-7)
1995
- Wilkinson, L. S., Humby, T., Robbins, T. W. and Everitt, B. J. 1995. Differential Effects of Forebrain 5-Hydroxytryptamine Depletions on Pavlovian Aversive Conditioning to Discrete and Contextual Stimuli in the Rat. European Journal of Neuroscience 7(10), pp. 2042-2052. (10.1111/j.1460-9568.1995.tb00627.x)
- Geyer, M. A., Wilkinson, L. S., Humby, T. and Robbins, T. W. 1995. Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]. Biological Psychiatry 37(9), pp. 634. (10.1016/0006-3223(95)94560-J)
Articles
- Wren, G., Flanagan, J., Underwood, J., Thompson, A., Humby, T. and Davies, W. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60, pp. 636-643. (10.1136/jmg-2022-108862)
- Wren, G., Humby, T., Thompson, A. and Davies, W. 2022. Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis. Clinical and Experimental Dermatology 47(6), pp. 1097-1108. (10.1111/ced.15116)
- Waldron, S. et al. 2022. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 21(4), article number: e12797. (10.1111/gbb.12797)
- Pass, R., Haan, N., Humby, T., Wilkinson, L. S., Hall, J. and Thomas, K. L. 2022. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior 21(4), article number: e12799. (10.1111/gbb.12799)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99, pp. 70-82. (10.1016/j.bbi.2021.09.005)
- Westacott, L. J. et al. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98, pp. 136-150. (10.1016/j.bbi.2021.08.215)
- Zahova, S., Humby, T., Davies, J., Morgan, J. E. and Isles, A. 2021. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Translational Psychiatry 11, article number: 433. (10.1038/s41398-021-01561-x)
- Dent, C. L., Rienecker, K. D. A., Ward, A., Wilkins, J. F., Humby, T. and Isles, A. R. 2020. Mice lacking paternal expression of imprinted 1 Grb10 are risk-takers. Genes, Brain and Behavior 19(7), article number: e12679. (10.1111/gbb.12679)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237, pp. 1745-1756. (10.1007/s00213-020-05496-x)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Davies, J. R., Wilkinson, L. S., Isles, A. R. and Humby, T. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28(18), pp. 3013-3023. (10.1093/hmg/ddz100)
- Silva, A. I. et al. 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10, article number: 3455. (10.1038/s41467-019-11119-7)
- Humby, T., Patel, Y., Carter, J., Stokes, L. G., Rogers, R. D. and Wilkinson, L. S. 2019. Feeding behaviour, risk-sensitivity and response control: effects of 5-HT 2C receptor manipulations. Philosophical Transactions B: Biological Sciences 374(1766), article number: 20180144. (10.1098/rstb.2018.0144)
- Isles, A. R., Winstanley, C. A. and Humby, T. 2019. Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications. Philosophical Transactions B: Biological Sciences 374(1766), pp. -., article number: 128. (10.1098/rstb.2018.0128)
- Humby, T. and Davies, W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Translational Neuroscience 10(1), pp. 168-174. (10.1515/tnsci-2019-0030)
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209(1), pp. 233-239. (10.1534/genetics.118.300898)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17(2), pp. 149-157. (10.1111/gbb.12422)
- Humby, T. et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior 7(3), article number: e00646. (10.1002/brb3.646)
- Humby, T., Cross, E. S., Messer, L., Guerrero, S. and Davies, W. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74, pp. 363-370. (10.1016/j.psyneuen.2016.09.019)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15(8), pp. 693-701. (10.1111/gbb.12316)
- Chatterjee, S., Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. PLoS ONE 11(10), pp. e0164417., article number: e0164417. (10.1371/journal.pone.0164417)
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42(4), pp. 2105-2113. (10.1111/ejn.12972)
- Davies, W., Humby, T., Trent, S., Eddy, J. B., Ojarikre, O. A. and Wilkinson, L. S. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39, pp. 2622-2632. (10.1038/npp.2014.115)
- Hiscox, L., Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20(3), pp. 208-224. (10.1002/dys.1480)
- Dent, C., Isles, A. R. and Humby, T. 2014. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience 39(4), pp. 520-530. (10.1111/ejn.12430)
- Humby, T., Eddy, J. B., Good, M. A., Reichelt, A. C. and Wilkinson, L. S. 2013. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology 38(11), pp. 2150-2159. (10.1038/npp.2013.112)
- Reichelt, A. C., Killcross, S., Wilkinson, L. S., Humby, T. and Good, M. A. 2013. Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory 104, pp. 73-81. (10.1016/j.nlm.2013.05.005)
- Kopsida, E., Lynn, P. M., Humby, T., Wilkinson, L. S. and Davies, W. 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8(8), article number: e73699. (10.1371/journal.pone.0073699)
- Trent, S. et al. 2013. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology 38(8), pp. 1370-1380. (10.1016/j.psyneuen.2012.12.002)
- Mikaelsson, M. A., Constância, M., Dent, C., Wilkinson, L. S. and Humby, T. 2013. Placental programming of anxiety in adulthood revealed by lgf2-null models. Nature Communications 4, article number: 2311. (10.1038/ncomms3311)
- Relkovic, D., Humby, T., Hagan, J. J., Wilkinson, L. S. and Isles, A. R. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126(3), pp. 488-492. (10.1037/a0028155)
- Trent, S., Cassano, T., Bedse, G., Ojarikre, O. A., Humby, T. and Davies, W. 2012. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology 37(5), pp. 1267-1274. (10.1038/npp.2011.314)
- Trent, S., Dennehy, A., Richardson, H., Ojarikre, O. A., Burgoyne, P. S., Humby, T. and Davies, W. 2012. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology 37(2), pp. 221-229. (10.1016/j.psyneuen.2011.06.006)
- Humby, T. and Wilkinson, L. S. 2011. Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology 11(5), pp. 534-539. (10.1016/j.coph.2011.06.006)
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31(1), pp. 156-164. (10.1111/j.1460-9568.2009.07048.x)
- Davies, W., Humby, T., Kong, W., Otter, T. L., Burgoyne, P. S. and Wilkinson, L. S. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66(4), pp. 360-367. (10.1016/j.biopsych.2009.01.001)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18(12), pp. 2140-2148. (10.1093/hmg/ddp137)
- Doe, C., Garfield, A., Humby, T., Relkovic, D., Wilkinson, L. S. and Isles, A. R. 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22(s2), pp. 125. (10.1111/j.1472-8206.2008.00601.x)
- Donald, S. et al. 2008. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America 105(11), pp. 4483-4488. (10.1073/pnas.0712324105)
- Lambourne, S. L., Humby, T., Isles, A. R., Emson, P. C., Spillantini, M. G. and Wilkinson, L. S. 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16(14), pp. 1708-1719. (10.1093/hmg/ddm119)
- Davies, W., Humby, T., Isles, A. R., Burgoyne, P. S. and Wilkinson, L. S. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61(12), pp. 1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W., Isles, A. R., Humby, T. and Wilkinson, L. S. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2(4), pp. 201-206. (10.4161/epi.2.4.5379)
- Colebrooke, R. E., Humby, T., Lynch, P. J., McGowan, D. P., Xia, J. and Emson, P. C. 2006. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. European Journal of Neuroscience 24(9), pp. 2622-2630. (10.1111/j.1460-9568.2006.05143.x)
- Tofaris, G. K. et al. 2006. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience 26(15), pp. 3942-3950. (10.1523/JNEUROSCI.4965-05.2006)
- Isles, A. R. and Humby, T. 2006. Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research 50(5), pp. 318-325. (10.1111/j.1365-2788.2006.00843.x)
- Isles, A. R., Hathway, G. J., Humby, T., de la Riva, C., Kendrick, K. M. and Wilkinson, L. S. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22(4), pp. 997-1000. (10.1111/j.1460-9568.2005.04265.x)
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37(6), pp. 625-629. (10.1038/ng1577)
- Plagge, A. et al. 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25(8), pp. 3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Isles, A. R., Humby, T., Walters, E. and Wilkinson, L. S. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24(30), pp. 6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
- Isles, A. R., Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170(4), pp. 376-382. (10.1007/s00213-003-1551-6)
- Davies, W., Isles, A. R., Burgoyne, P. S., Ward, B. O., Humby, T., de la Riva, C. and Wilkinson, L. S. 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17(S), pp. A70.
- Mooslehner, K. A. et al. 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21(16), pp. 5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
- Caine, S. B., Humby, T., Robbins, T. W. and Everitt, B. J. 2001. Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle. Behavioral Neuroscience 115(4), pp. 880-894. (10.1037/0735-7044.115.4.880)
- Baunez, C., Humby, T., Eagle, D. M., Ryan, L. J., Dunnett, S. B. and Robbins, T. W. 2001. Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience 13(8), pp. 1609-1616. (10.1046/j.0953-816x.2001.01521.x)
- Passetti, F., Humby, T., Everitt, B. J. and Robbins, T. W. 2000. Mixed attentional and executive deficits in medial frontal cortex lesioned rats. Psychobiology 28(2), pp. 261-271.
- Humby, T., Laird, F. M., Davies, W. and Wilkinson, L. S. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11(8), pp. 2813-2823. (10.1046/j.1460-9568.1999.00701.x)
- Eagle, D. M., Humby, T., Dunnett, S. B. and Robbins, T. W. 1999. Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behavioral Neuroscience 113(4), pp. 718-731. (10.1037/0735-7044.113.4.718)
- Eagle, D. M., Humby, T., Howman, M., Reid-Henry, A., Dunnett, S. B. and Robbins, T. W. 1999. Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats. Psychobiology 27(2), pp. 267-276.
- Hall, F. S., Wilkinson, L. S., Humby, T. and Robbins, T. W. 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32(1), pp. 37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)
- Carter, R. J. et al. 1999. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. The Journal of Neuroscience 19(8), pp. 3248-3257.
- French, S. J., Humby, T., Horner, C. H., Sofroniew, M. V. and Rattray, M. 1999. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Molecular Brain Research 67(1), pp. 124-136. (10.1016/S0169-328X(99)00048-0)
- Hall, F. S., Wilkinson, L. S., Humby, T., Inglis, W., Kendall, D. A., Marsden, C. A. and Robbins, T. W. 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59(4), pp. 859-872. (10.1016/S0091-3057(97)00510-8)
- Wilkinson, L. S., Humby, T., Killcross, A. S., Torres, E., Everitt, B. J. and Robbins, T. W. 1998. Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience 10(3), pp. 1019-1026. (10.1046/j.1460-9568.1998.00119.x)
- Eagle, D. M., Humby, T., Robbins, T. W. and Dunnett, S. B. 1998. A progressive ratio study of response to reward following striatal damage [Abstract]. European Journal of Neuroscience 10(S), pp. 418.
- French, S. J., Rattray, M., Humby, T. and Sofronlew, M. 1998. Regulation of hippocampal neurotrophin gene expression by sub-toxic and behaviourally inactive doses of glutamatergic and cholinergic agonists [Abstract]. European Journal of Neuroscience 10(S), pp. 116.
- Brasted, P. J., Humby, T., Dunnett, S. B. and Robbins, T. W. 1997. Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. The Journal of Neuroscience 17(22), pp. 8919-8926.
- Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. 1997. The effects of isolation-rearing on preference by rats for a novel environment. Physiology & Behavior 62(2), pp. 299-303. (10.1016/S0031-9384(97)00117-0)
- Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. 1997. The effects of isolation-rearing on sucrose consumption in rats. Physiology & Behavior 62(2), pp. 291-297. (10.1016/S0031-9384(97)00116-9)
- Hall, F. S., Humby, T., Wilkinson, L. S. and Robbins, T. W. 1997. The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior 62(2), pp. 281-290. (10.1016/S0031-9384(97)00115-7)
- Wilkinson, L. S., Humby, T., Robbins, T. W. and Everitt, B. J. 1995. Differential Effects of Forebrain 5-Hydroxytryptamine Depletions on Pavlovian Aversive Conditioning to Discrete and Contextual Stimuli in the Rat. European Journal of Neuroscience 7(10), pp. 2042-2052. (10.1111/j.1460-9568.1995.tb00627.x)
- Geyer, M. A., Wilkinson, L. S., Humby, T. and Robbins, T. W. 1995. Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]. Biological Psychiatry 37(9), pp. 634. (10.1016/0006-3223(95)94560-J)
Book sections
- Davies, W., Isles, A. R., Humby, T. and Wilkinson, L. S. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626. Berlin: Springer, pp. 62-70., (10.1007/978-0-387-77576-0_5)
- Humby, T. and Wilkinson, L. S. 2006. If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. S. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Contemporary Clinical Neuroscience Totowa, NJ: Humana Press, pp. 69-83., (10.1007/978-1-59745-058-4_4)
- Humby, T., Wilkinson, L. S. and Dawson, G. 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. In: Current Protocols in Neuroscience. Chichester: Wiley, (10.1002/0471142301.ns0805hs31)
Ymchwil
Research topics and related papers
Research focuses on the role of genetics in neurological disorders and brain function/dysfunction. This work involves the design and implementation of novel behavioural tasks for assessing cognition in gene manipulation or transgenic mouse models of human disorders and subsequent investigation of the underlying neurobiological changes. Particular areas of interest:
- investigating the possible importance of imprinted genes in early development and the putative long term effects dysfunction may have of adult cognition and behaviour (supervision of PhD student Mikael Mikaelsson) in collaboration with Miguel Constancia (University of Cambridge)
- investigating the mechanisms of gene dysfunction in schizophrenia and effects on cognition (supervision of PhD students Tamara Al-Janabi and Jess Eddy) in collaboration with Mike Owen and Mick O’Donovan (School of Medicine, Cardiff)
- investigating the relationship between tau-related pathology and cognition in a transgenic mouse model of fronto-temporal dementia in collaboration with Maria Grazia Spillantini (University of Cambridge)
- investigating the role of imprinted genes on brain function in collaboration with Will Davies, Anthony Isles and Lawrence Wilkinson
- investigating the role of X and Y chromosome genes in ADHD in collaboration with Will Davies
- investigating the electrophysiological signatures of different brain regions during performance of paradigms which assess impulse control (SARTE consortium).
Funding
Genes and Development Summer Studentship, The Genetics Society: Investigating social memory and interactions in mouse models of schizophrenia. 22/5/12, £3,000
SARTRE research consortium: The neurophysiological basis of response inhibition and its use in diagnosis of complex frontal cortical dysfunction. 1/4/10, £30,000
Research group
I collaborate closely with other members of the Behavioural Genetics Group that was formed when on moving from the Babraham Institute in 2006. The BGG includes:
Professor Lawrence Wilkinson
Dr Anthony Isles
Dr Will Davies
Dr Jo Haddon
Research collaborators
In addition to other members of the BGG I also work with the following people at other institutions:
Dr Matt Jones (Bristol, SARTRE consortium)
Dr Lynsey Forsyth (Bristol, SARTRE consortium)
Dr Liz Coulthard (Bristol, SARTRE consortium)
Dr Miguel Constancia (University of Cambridge): investigating the possible importance of imprinted genes in early development and the putative long term effects dysfunction may have of adult cognition and behaviour
Prof Maria Grazia Spillantini (University of Cambridge): investigating the relationship between tau-related pathology and cognition in a transgenic mouse model of fronto-temporal dementia
Addysgu
I teach in 1st and 2nd year modules, with introductory lectures on individual differences (intelligence, personality and abnormal psychology/mental health conditions) in the 1st year (PS1016). In the 2nd year, I teach in the abnormal and clinical psychology module (PS2018) with lectures covering ADHD and neurodcognative diseases.
I have supervised final year projects with a wide variety of subjects.
I am module co-ordinator for the 1st year module PS1016 Introduction to Psychology and for the 2nd year module PS2018 Abnormal and Clinical Psychology.
I am the co-ordinator for the Schoolo of Pscyhology summer research opportunities scheme SPRInt.
Bywgraffiad
Addysg israddedig
Baglor Gwyddoniaeth (gydag Anrhydedd) mewn Niwrobioleg, Prifysgol Sussex
Addysg ôl-raddedig
Doethur mewn Athroniaeth, Prifysgol Caergrawnt.
Teitl traethawd ymchwil, 'Effeithiau treigladau genynnau sy'n ymwneud â chlefyd Alzheimer teuluol ar weithredu ymddygiadol a niwral'.
Cyfarwyddwr: Dr. Lawrence Wilkinson.
Aelodaeth
Cymdeithas Seicopharmacoleg Prydain (BAP, ers 1990)
Cymdeithas Niwrowyddoniaeth Prydain (BNA, ers 1989)
Cymdeithas Niwrowyddoniaeth (SFN, ers 2000)
Y Gymdeithas Geneteg (ers 2009)
Arall__________
Adolygydd llawysgrifau a gyflwynwyd ar gyfer European Journal of Neuroscience, Psychopharmacology, Behavioural Brain Research, Journal of Psychopharmacology
Anrhydeddau a dyfarniadau
Gwobrau/pwyllgorau allanol
Derbynydd ysgoloriaeth ymchwil gwobr Oon Khye Beng Ch'hia Tsio am feddygaeth ataliol a gynigir gan Goleg Downing, Caergrawnt. (1998-2001).
Meysydd goruchwyliaeth
Diddordebau ymchwil ôl-raddedig
Mae gen i ddiddordeb mewn sut mae cefndir genetig a ffactorau amgylcheddol cynnar yn rhyngweithio i arwain at effeithiau tymor hir, parhaus ar swyddogaeth ac ymddygiad yr ymennydd. Mae fy ymchwil ar hyn o bryd yn canolbwyntio ar ddosbarth genynnau a ddarganfuwyd yn ddiweddar, o'r enw genynnau sydd wedi'u hargraffu. Mae genynnau sydd heb eu hargraffu yn od gan fod yr ymadrodd hwnnw ond yn digwydd o naill ai'r alel a etifeddwyd gan fam neu'r alel a etifeddwyd gan dad yn hytrach na'r mwyafrif mawr o enynnau lle mae'r ddau gopi yn cael eu mynegi'r un mor ddibwys o'u tarddiad rhiant. Mae bodolaeth genynnau argraffedig yn codi llawer o faterion esblygiadol hynod ddiddorol ond maen nhw o'r diddordeb mwyaf uniongyrchol i mi oherwydd eu rôl allweddol mewn twf a datblygiad. Yn fy ymchwil gyfredol, rwy'n profi'r syniad y gall gweithredu genynnau argraffedig, yn y brych a'r ymennydd, ddylanwadu ar ganlyniadau gwybyddol ac ymddygiadol trwy effeithiau ar dwf cyn-enedigol ac ôl-enedigol. Yn flaenorol, rwyf wedi cael diddordebau mewn polymorffeddau genetig sy'n dylanwadu ar reoli ymateb a mwtaniadau genynnau sy'n sail i ddementia teuluol.
Os oes gennych ddiddordeb mewn gwneud cais am PhD, neu am ragor o wybodaeth am fy ymchwil ôl-raddedig, cysylltwch â mi'n uniongyrchol (manylion cyswllt ar gael ar y dudalen 'Trosolwg'), neu gyflwyno cais ffurfiol.
