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Dr Trevor Humby
(e/fe)
BSc (Hons) Sussex, PhD Cambridge
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Trevor Humby
Darllenydd
Trosolwg
Rwy'n niwrowyddonydd sy'n cael ei gydnabod fel arbenigwr mewn niwrowyddoniaeth ymddygiadol, geneteg a ffarmacoleg. Mae gen i dros 25 mlynedd o brofiad mewn ymchwil sy'n seiliedig ar gnofilod, wedi cyhoeddi >85 o erthyglau y rhan fwyaf yn y sgôr 3*/4* ar gyfer REF, ac wedi goruchwylio a mentora >30 o fyfyrwyr ôl-raddedig. Mae gen i gydweithrediadau â grwpiau cenedlaethol a rhyngwladol yn ogystal â chydweithrediadau lleol gyda chydweithwyr mewn ysgolion ar draws y BLS yng Nghaerdydd. Mae fy ymchwil yn ymchwilio i effeithiau ffactor risg genetig ar ymddygiad gan ddefnyddio modelau anifeiliaid, gan gysylltu canfyddiadau ymddygiadol â marcwyr niwrobiolegol, ac oddi yno i fecanweithiau achub.
Rwyf wedi bod yn gyfrifol am ddatblygu a nodweddu ystod o dasgau gweithredol arloesol a reolir gan gyfrifiadur ar gyfer asesu swyddogaeth ymddygiadol a gwybyddol mewn llygod mawr a llygod ond rwyf hefyd wedi datblygu a dilysu profion mwy syml ar gyfer ymchwilio i bryder, ymddygiad echddygol, cof a rhyngweithiadau cymdeithasol, gan ledaenu'r dulliau hyn i gydweithwyr yn lleol ac yn fyd-eang.
Cyhoeddiad
2026
- Humby, T. et al. 2026. Physiological and behavioural characterisation of a novel steroid sulfatase‐deficient mouse. Genes, Brain and Behavior 25 (4) e70061. (10.1111/gbb.70061)
- Hornsby, A. K. E. et al. 2026. Stress‐induced hyperphagia? Characterising the activity of the ghrelin axis in male rats with high anxiety behaviour. Journal of Neuroendocrinology 38 (1) e70106. (10.1111/jne.70106)
2025
- Wren, G. et al. 2025. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Archives of Dermatological Research 317 351. (10.1007/s00403-025-03884-x)
2024
- Wren, G. et al. 2024. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Research Square
- Wren, G. et al. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior 23 (3) e12893. (10.1111/gbb.12893)
- Bosworth, M. L. et al. 2024. Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. PLoS ONE (10.1371/journal.pone.0298717)
2023
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60 , pp.636-643. (10.1136/jmg-2022-108862)
2022
- Wren, G. et al. 2022. Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis. Clinical and Experimental Dermatology 47 (6), pp.1097-1108. (10.1111/ced.15116)
- Pass, R. et al. 2022. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior 21 (4) e12799. (10.1111/gbb.12799)
- Waldron, S. et al. 2022. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 21 (4) e12797. (10.1111/gbb.12797)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99 , pp.70-82. (10.1016/j.bbi.2021.09.005)
2021
- Westacott, L. J. et al. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98 , pp.136-150. (10.1016/j.bbi.2021.08.215)
- Zahova, S. et al. 2021. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Translational Psychiatry 11 433. (10.1038/s41398-021-01561-x)
2020
- Dent, C. L. et al. 2020. Mice lacking paternal expression of imprinted 1 Grb10 are risk-takers. Genes, Brain and Behavior 19 (7) e12679. (10.1111/gbb.12679)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237 , pp.1745-1756. (10.1007/s00213-020-05496-x)
2019
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Davies, J. R. et al. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28 (18), pp.3013-3023. (10.1093/hmg/ddz100)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
- Humby, T. et al. 2019. Feeding behaviour, risk-sensitivity and response control: effects of 5-HT 2C receptor manipulations. Philosophical Transactions B: Biological Sciences 374 (1766) 20180144. (10.1098/rstb.2018.0144)
- Isles, A. R. , Winstanley, C. A. and Humby, T. 2019. Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications. Philosophical Transactions B: Biological Sciences 374 (1766), pp.-. 0128. (10.1098/rstb.2018.0128)
- Humby, T. and Davies, W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Translational Neuroscience 10 (1), pp.168-174. (10.1515/tnsci-2019-0030)
2018
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209 (1), pp.233-239. (10.1534/genetics.118.300898)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2), pp.149-157. (10.1111/gbb.12422)
2017
- Humby, T. et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior 7 (3) e00646. (10.1002/brb3.646)
2016
- Humby, T. et al. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74 , pp.363-370. (10.1016/j.psyneuen.2016.09.019)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15 (8), pp.693-701. (10.1111/gbb.12316)
- Chatterjee, S. , Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. PLoS ONE 11 (10), pp.e0164417. e0164417. (10.1371/journal.pone.0164417)
2015
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4), pp.2105-2113. (10.1111/ejn.12972)
2014
- Davies, W. et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39 , pp.2622-2632. (10.1038/npp.2014.115)
- Dent, C. , Isles, A. R. and Humby, T. 2014. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience 39 (4), pp.520-530. (10.1111/ejn.12430)
- Hiscox, L. , Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20 (3), pp.208-224. (10.1002/dys.1480)
2013
- Kopsida, E. et al., 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8 (8) e73699. (10.1371/journal.pone.0073699)
- Humby, T. et al. 2013. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology 38 (11), pp.2150-2159. (10.1038/npp.2013.112)
- Mikaelsson, M. A. et al. 2013. Placental programming of anxiety in adulthood revealed by lgf2-null models. Nature Communications 4 2311. (10.1038/ncomms3311)
- Reichelt, A. C. et al. 2013. Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory 104 , pp.73-81. (10.1016/j.nlm.2013.05.005)
- Trent, S. et al. 2013. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology 38 (8), pp.1370-1380. (10.1016/j.psyneuen.2012.12.002)
2012
- Trent, S. et al. 2012. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology 37 (2), pp.221-229. (10.1016/j.psyneuen.2011.06.006)
- Relkovic, D. et al. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126 (3), pp.488-492. (10.1037/a0028155)
- Trent, S. et al. 2012. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology 37 (5), pp.1267-1274. (10.1038/npp.2011.314)
2011
- Humby, T. and Wilkinson, L. S. 2011. Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology 11 (5), pp.534-539. (10.1016/j.coph.2011.06.006)
2010
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31 (1), pp.156-164. (10.1111/j.1460-9568.2009.07048.x)
2009
- Davies, W. et al. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66 (4), pp.360-367. (10.1016/j.biopsych.2009.01.001)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18 (12), pp.2140-2148. (10.1093/hmg/ddp137)
2008
- Donald, S. et al., 2008. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America 105 (11), pp.4483-4488. (10.1073/pnas.0712324105)
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
- Doe, C. et al., 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22 (s2), pp.125. (10.1111/j.1472-8206.2008.00601.x)
2007
- Lambourne, S. L. et al., 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16 (14), pp.1708-1719. (10.1093/hmg/ddm119)
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
2006
- Tofaris, G. K. et al., 2006. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience 26 (15), pp.3942-3950. (10.1523/JNEUROSCI.4965-05.2006)
- Colebrooke, R. E. et al., 2006. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. European Journal of Neuroscience 24 (9), pp.2622-2630. (10.1111/j.1460-9568.2006.05143.x)
- Humby, T. and Wilkinson, L. S. 2006. If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. S. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Contemporary Clinical Neuroscience Totowa, NJ: Humana Press. , pp.69-83. (10.1007/978-1-59745-058-4_4)
- Isles, A. R. and Humby, T. 2006. Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research 50 (5), pp.318-325. (10.1111/j.1365-2788.2006.00843.x)
2005
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Plagge, A. et al., 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25 (8), pp.3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Humby, T. , Wilkinson, L. S. and Dawson, G. 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. In: Current Protocols in Neuroscience. Chichester: Wiley(10.1002/0471142301.ns0805hs31)
- Isles, A. R. et al. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22 (4), pp.997-1000. (10.1111/j.1460-9568.2005.04265.x)
2004
- Isles, A. R. et al. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24 (30), pp.6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
2003
- Davies, W. et al., 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17 (S), pp.A70.
- Isles, A. R. , Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170 (4), pp.376-382. (10.1007/s00213-003-1551-6)
2001
- Baunez, C. et al., 2001. Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience 13 (8), pp.1609-1616. (10.1046/j.0953-816x.2001.01521.x)
- Caine, S. B. et al., 2001. Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle. Behavioral Neuroscience 115 (4), pp.880-894. (10.1037/0735-7044.115.4.880)
- Mooslehner, K. A. et al., 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21 (16), pp.5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
2000
- Passetti, F. et al., 2000. Mixed attentional and executive deficits in medial frontal cortex lesioned rats. Psychobiology 28 (2), pp.261-271.
1999
- Carter, R. J. et al., 1999. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. The Journal of Neuroscience 19 (8), pp.3248-3257.
- Eagle, D. M. et al., 1999. Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behavioral Neuroscience 113 (4), pp.718-731. (10.1037/0735-7044.113.4.718)
- Eagle, D. M. et al., 1999. Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats. Psychobiology 27 (2), pp.267-276.
- French, S. J. et al., 1999. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Molecular Brain Research 67 (1), pp.124-136. (10.1016/S0169-328X(99)00048-0)
- Hall, F. S. et al., 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32 (1), pp.37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)
- Humby, T. et al. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11 (8), pp.2813-2823. (10.1046/j.1460-9568.1999.00701.x)
1998
- Eagle, D. M. et al., 1998. A progressive ratio study of response to reward following striatal damage [Abstract]. European Journal of Neuroscience 10 (S), pp.418.
- Hall, F. S. et al., 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59 (4), pp.859-872. (10.1016/S0091-3057(97)00510-8)
- Wilkinson, L. S. et al. 1998. Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience 10 (3), pp.1019-1026. (10.1046/j.1460-9568.1998.00119.x)
1997
- Brasted, P. J. et al., 1997. Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. The Journal of Neuroscience 17 (22), pp.8919-8926.
- Hall, F. S. et al., 1997. The effects of isolation-rearing of rats on behavioural responses to food and environmental novelty. Physiology & Behavior 62 (2), pp.281-290. (10.1016/S0031-9384(97)00115-7)
- Hall, F. S. et al., 1997. The effects of isolation-rearing on preference by rats for a novel environment. Physiology & Behavior 62 (2), pp.299-303. (10.1016/S0031-9384(97)00117-0)
- Hall, F. S. et al., 1997. The effects of isolation-rearing on sucrose consumption in rats. Physiology & Behavior 62 (2), pp.291-297. (10.1016/S0031-9384(97)00116-9)
1995
- Geyer, M. A. et al., 1995. Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]. Biological Psychiatry 37 (9), pp.634. (10.1016/0006-3223(95)94560-J)
- Wilkinson, L. S. et al. 1995. Differential Effects of Forebrain 5-Hydroxytryptamine Depletions on Pavlovian Aversive Conditioning to Discrete and Contextual Stimuli in the Rat. European Journal of Neuroscience 7 (10), pp.2042-2052. (10.1111/j.1460-9568.1995.tb00627.x)
Articles
- Humby, T. et al. 2026. Physiological and behavioural characterisation of a novel steroid sulfatase‐deficient mouse. Genes, Brain and Behavior 25 (4) e70061. (10.1111/gbb.70061)
- Hornsby, A. K. E. et al. 2026. Stress‐induced hyperphagia? Characterising the activity of the ghrelin axis in male rats with high anxiety behaviour. Journal of Neuroendocrinology 38 (1) e70106. (10.1111/jne.70106)
- Wren, G. et al. 2025. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Archives of Dermatological Research 317 351. (10.1007/s00403-025-03884-x)
- Wren, G. et al. 2024. Monitoring heart rhythms in adult males with X-linked ichthyosis using wearable technology: a feasibility study. Research Square
- Wren, G. et al. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior 23 (3) e12893. (10.1111/gbb.12893)
- Bosworth, M. L. et al. 2024. Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. PLoS ONE (10.1371/journal.pone.0298717)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60 , pp.636-643. (10.1136/jmg-2022-108862)
- Wren, G. et al. 2022. Mood symptoms, neurodevelopmental traits, and their contributory factors in X-linked ichthyosis, ichthyosis vulgaris and psoriasis. Clinical and Experimental Dermatology 47 (6), pp.1097-1108. (10.1111/ced.15116)
- Pass, R. et al. 2022. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior 21 (4) e12799. (10.1111/gbb.12799)
- Waldron, S. et al. 2022. Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. Genes, Brain and Behavior 21 (4) e12797. (10.1111/gbb.12797)
- Westacott, L. J. et al. 2022. Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder. Brain, Behavior, and Immunity 99 , pp.70-82. (10.1016/j.bbi.2021.09.005)
- Westacott, L. J. et al. 2021. Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice. Brain, Behavior, and Immunity 98 , pp.136-150. (10.1016/j.bbi.2021.08.215)
- Zahova, S. et al. 2021. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Translational Psychiatry 11 433. (10.1038/s41398-021-01561-x)
- Dent, C. L. et al. 2020. Mice lacking paternal expression of imprinted 1 Grb10 are risk-takers. Genes, Brain and Behavior 19 (7) e12679. (10.1111/gbb.12679)
- Humby, T. et al. 2020. Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours. Psychopharmacology 237 , pp.1745-1756. (10.1007/s00213-020-05496-x)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45 (5), pp.1024-1032. (10.1093/schbul/sby146)
- Davies, J. R. et al. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28 (18), pp.3013-3023. (10.1093/hmg/ddz100)
- Silva, A. I. et al., 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10 3455. (10.1038/s41467-019-11119-7)
- Humby, T. et al. 2019. Feeding behaviour, risk-sensitivity and response control: effects of 5-HT 2C receptor manipulations. Philosophical Transactions B: Biological Sciences 374 (1766) 20180144. (10.1098/rstb.2018.0144)
- Isles, A. R. , Winstanley, C. A. and Humby, T. 2019. Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications. Philosophical Transactions B: Biological Sciences 374 (1766), pp.-. 0128. (10.1098/rstb.2018.0128)
- Humby, T. and Davies, W. 2019. Brain gene expression in a novel mouse model of postpartum mood disorder. Translational Neuroscience 10 (1), pp.168-174. (10.1515/tnsci-2019-0030)
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209 (1), pp.233-239. (10.1534/genetics.118.300898)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2), pp.149-157. (10.1111/gbb.12422)
- Humby, T. et al. 2017. A genetic variant within STS previously associated with inattention in boys with Attention Deficit Hyperactivity Disorder is associated with enhanced cognition in healthy adult males. Brain and Behavior 7 (3) e00646. (10.1002/brb3.646)
- Humby, T. et al. 2016. A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis. Psychoneuroendocrinology 74 , pp.363-370. (10.1016/j.psyneuen.2016.09.019)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15 (8), pp.693-701. (10.1111/gbb.12316)
- Chatterjee, S. , Humby, T. and Davies, W. 2016. Behavioural and psychiatric phenotypes in men and boys with X-linked ichthyosis: evidence from a worldwide online survey. PLoS ONE 11 (10), pp.e0164417. e0164417. (10.1371/journal.pone.0164417)
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4), pp.2105-2113. (10.1111/ejn.12972)
- Davies, W. et al. 2014. Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison to drugs used in ADHD. Neuropsychopharmacology 39 , pp.2622-2632. (10.1038/npp.2014.115)
- Dent, C. , Isles, A. R. and Humby, T. 2014. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience 39 (4), pp.520-530. (10.1111/ejn.12430)
- Hiscox, L. , Leonaviciute, E. and Humby, T. 2014. The effects of automatic spelling correction software on understanding and comprehension in compensated dyslexia: improved recall following dictation. Dyslexia 20 (3), pp.208-224. (10.1002/dys.1480)
- Kopsida, E. et al., 2013. Dissociable effects of sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE 8 (8) e73699. (10.1371/journal.pone.0073699)
- Humby, T. et al. 2013. A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism. Neuropsychopharmacology 38 (11), pp.2150-2159. (10.1038/npp.2013.112)
- Mikaelsson, M. A. et al. 2013. Placental programming of anxiety in adulthood revealed by lgf2-null models. Nature Communications 4 2311. (10.1038/ncomms3311)
- Reichelt, A. C. et al. 2013. Transgenic expression of the FTDP-17 tauV337M mutation in brain dissociates components of executive function in mice. Neurobiology of Learning and Memory 104 , pp.73-81. (10.1016/j.nlm.2013.05.005)
- Trent, S. et al. 2013. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology 38 (8), pp.1370-1380. (10.1016/j.psyneuen.2012.12.002)
- Trent, S. et al. 2012. Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder. Psychoneuroendocrinology 37 (2), pp.221-229. (10.1016/j.psyneuen.2011.06.006)
- Relkovic, D. et al. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126 (3), pp.488-492. (10.1037/a0028155)
- Trent, S. et al. 2012. Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice. Neuropsychopharmacology 37 (5), pp.1267-1274. (10.1038/npp.2011.314)
- Humby, T. and Wilkinson, L. S. 2011. Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models. Current Opinion in Pharmacology 11 (5), pp.534-539. (10.1016/j.coph.2011.06.006)
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31 (1), pp.156-164. (10.1111/j.1460-9568.2009.07048.x)
- Davies, W. et al. 2009. Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biological Psychiatry 66 (4), pp.360-367. (10.1016/j.biopsych.2009.01.001)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18 (12), pp.2140-2148. (10.1093/hmg/ddp137)
- Donald, S. et al., 2008. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proceedings of the National Academy of Sciences of the United States of America 105 (11), pp.4483-4488. (10.1073/pnas.0712324105)
- Doe, C. et al., 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22 (s2), pp.125. (10.1111/j.1472-8206.2008.00601.x)
- Lambourne, S. L. et al., 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16 (14), pp.1708-1719. (10.1093/hmg/ddm119)
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Tofaris, G. K. et al., 2006. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. Journal of Neuroscience 26 (15), pp.3942-3950. (10.1523/JNEUROSCI.4965-05.2006)
- Colebrooke, R. E. et al., 2006. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. European Journal of Neuroscience 24 (9), pp.2622-2630. (10.1111/j.1460-9568.2006.05143.x)
- Isles, A. R. and Humby, T. 2006. Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research 50 (5), pp.318-325. (10.1111/j.1365-2788.2006.00843.x)
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Plagge, A. et al., 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25 (8), pp.3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Isles, A. R. et al. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22 (4), pp.997-1000. (10.1111/j.1460-9568.2005.04265.x)
- Isles, A. R. et al. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24 (30), pp.6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
- Davies, W. et al., 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17 (S), pp.A70.
- Isles, A. R. , Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170 (4), pp.376-382. (10.1007/s00213-003-1551-6)
- Baunez, C. et al., 2001. Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience 13 (8), pp.1609-1616. (10.1046/j.0953-816x.2001.01521.x)
- Caine, S. B. et al., 2001. Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle. Behavioral Neuroscience 115 (4), pp.880-894. (10.1037/0735-7044.115.4.880)
- Mooslehner, K. A. et al., 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21 (16), pp.5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
- Passetti, F. et al., 2000. Mixed attentional and executive deficits in medial frontal cortex lesioned rats. Psychobiology 28 (2), pp.261-271.
- Carter, R. J. et al., 1999. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. The Journal of Neuroscience 19 (8), pp.3248-3257.
- Eagle, D. M. et al., 1999. Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behavioral Neuroscience 113 (4), pp.718-731. (10.1037/0735-7044.113.4.718)
- Eagle, D. M. et al., 1999. Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats. Psychobiology 27 (2), pp.267-276.
- French, S. J. et al., 1999. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Molecular Brain Research 67 (1), pp.124-136. (10.1016/S0169-328X(99)00048-0)
- Hall, F. S. et al., 1999. Maternal deprivation of neonatal rats produces enduring changes in dopamine function. Synapse 32 (1), pp.37-43. (10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4)
- Humby, T. et al. 1999. Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience 11 (8), pp.2813-2823. (10.1046/j.1460-9568.1999.00701.x)
- Eagle, D. M. et al., 1998. A progressive ratio study of response to reward following striatal damage [Abstract]. European Journal of Neuroscience 10 (S), pp.418.
- Hall, F. S. et al., 1998. Isolation rearing in rats: Pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacology, Biochemistry and Behavior 59 (4), pp.859-872. (10.1016/S0091-3057(97)00510-8)
- Wilkinson, L. S. et al. 1998. Dissociations in dopamine release in medial prefrontal cortex and ventral striatum during the acquisition and extinction of classical aversive conditioning in the rat. European Journal of Neuroscience 10 (3), pp.1019-1026. (10.1046/j.1460-9568.1998.00119.x)
- Brasted, P. J. et al., 1997. Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. The Journal of Neuroscience 17 (22), pp.8919-8926.
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Book sections
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
- Humby, T. and Wilkinson, L. S. 2006. If only they could talk - genetic mouse models for psychiatric disorders. In: Fish, G. S. and Flint, J. eds. Transgenic and Knockout Models of Neuropsychiatric Disorders. Contemporary Clinical Neuroscience Totowa, NJ: Humana Press. , pp.69-83. (10.1007/978-1-59745-058-4_4)
- Humby, T. , Wilkinson, L. S. and Dawson, G. 2005. UNIT 8.5H assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. In: Current Protocols in Neuroscience. Chichester: Wiley(10.1002/0471142301.ns0805hs31)
Ymchwil
Mae'r dudalen hon yn cael ei diweddaru (Chwefror 2026)
Addysgu
Rwy'n addysgu mewn modiwlau blwyddyn 1a'r 2il flwyddyn (Lefelau 4 a 5), gyda darlithoedd rhagarweiniol am wahaniaethau unigol (deallusrwydd, personoliaeth a seicoleg annormal/cyflyrau iechyd meddwl) yny flwyddyn 1af (PS1016). Yn yr2il flwyddyn, rwy'n addysgu yn y modiwl Iechyd Meddwl a Seicoleg Glinigol (PS2028) gyda darlithoedd sy'n ymdrin ag ADHD a chlefydau niwrowybyddol.
Rwyf hefyd yn gydlynydd modiwl ar gyfer yr2il flwyddyn (Lefel 5) modiwl PS2028 Iechyd Meddwl a Seicoleg Glinigol. Yn y swydd hon mae gen i gyfrifoldeb am gynnull y gwahanol ddarnau o waith cwrs ac arholiad terfynol, a rhedeg y modiwl yn llyfn.
Rwy'n goruchwylio prosiectau blwyddyn olaf (Lefel 6) ar draws amrywiaeth eang o bynciau, ar gyfartaledd 6 myfyriwr y flwyddyn. Rwy'n hapus i oruchwylio ar draws y rhan fwyaf o themâu neu feysydd (yn amodol ar ymarferoldeb – h.y. gallu gwneud yr arbrawf mewn gwirionedd! (mynediad at adnoddau penodol penodol, grwpiau cyfranogwyr ac ati) - ond gall hefyd gymhwyso tro diddorol i un o fy syniadau i gymysgu â diddordebau myfyrwyr. Rwyf hefyd yn awyddus bod themâu prosiect yn ymwneud â llwybr gyrfa myfyrwyr.
Rwy'n MSc (Lefel 7) Goruchwyliwr Lleoliad / marciwr ar gyfer y modiwl PST725.
Rwyf hefyd yn oruchwyliwr i fyfyrwyr PhD.
Bywgraffiad
Lleoliad presennol
- Ymchwilydd mewn Niwrowyddoniaeth Ymddygiadol
- Darlithydd ar gyfer modiwlau Blwyddyn 1 a Blwyddyn 2
- Goruchwyliwr PhD ac MSc
- Cadeirydd Ysgol Seicoleg Pwyllgor Moeseg Ymchwil (SREC)
- Aelod nad yw'n ysgol o bwyllgorau moeseg Ysgolion Meddygaeth a Chyfraith/Gwleidyddiaeth
Cwblheais fy ngradd israddedig mewn Niwrorioleg yn Sussex. Ar ôl graddio, gweithiais fel cynorthwyydd ymchwil gyda Dr Tom Collet yn Sussex, gan barhau â'm prosiect ymchwil blwyddyn olaf ar ddysgu mewn gwenyn mêl. Yna symudais i Gaergrawnt lle gweithiais gyda'r Athro Joe Herbert, Batty Everitt a Mick Hastings yn yr adran Anatomeg, cyn symud i'r adran Seicoleg Arbrofol, gan weithio gyda'r Athro Trevor Robbins. O'r fan hon symudais i Ganolfan Atgyweirio Ymennydd Caergrawnt, gan weithio gyda'r Athro Steve Dunnett cyn dechrau fy astudiaethau PhD, dan oruchwyliaeth yr Athro Lawrence Wilkinson yn Sefydliad Babraham, Caergrawnt.
Yn 2006 symudais i Brifysgol Caerdydd, fel darlithydd, yn yr ysgol Seicoleg ond hefyd yn gweithio yn yr ysgol Meddygaeth. Wedi hynny rwyf wedi cael fy nyrchafu'n uwch ddarlithydd ac ar hyn o bryd rwy'n Ddarllenydd.
Addysg israddedig
Baglor mewn Gwyddoniaeth (gydag Anrhydedd) mewn Nirobioleg, Prifysgol Sussex
Addysg ôl-raddedig
Doethur mewn Athroniaeth, Prifysgol Caergrawnt. Teitl y traethawd hir, 'Effects of mutations of genes involved in familyal Alzheimer's disease on behavioural and neural functioning'. Goruchwylydd: Dr. Lawrence Wilkinson.
Aelodaeth
- Cymdeithas Seicoffarmacoleg Prydain (BAP, ers 1990)
- Cymdeithas Niwrowyddoniaeth Prydain (BNA, ers 1989)
- Cymdeithas Niwrowyddoniaeth (SFN, ers 2000)
- Y Gymdeithas Geneteg (ers 2009)
Arall
Adolygydd llawysgrifau a gyflwynwyd ar gyfer European Journal of Neuroscience, Psychopharmacology, Behavioral Brain Research, Journal of Psychopharmacology
Adolygydd grant ar gyfer MRC, BBSRC, Wellcome, Sefydliad Waterloo
Anrhydeddau a dyfarniadau
Meysydd goruchwyliaeth
Diddordebau ymchwil ôl-raddedig
Mae gen i ddiddordeb mewn sut mae cefndir genetig a ffactorau amgylcheddol cynnar yn rhyngweithio i arwain at effeithiau hirdymor, parhaol ar swyddogaeth ac ymddygiad yr ymennydd. Gall astudiaethau gynnwys dadansoddiad model cyn-glinigol o ymddygiad a congition, sy'n gysylltiedig ag ymchwiliadau moleciwlaidd ac anatocial. Mae'r astudiaethau hyn yn defnyddio modelau wedi'u haddasu'n enetig, sy'n gysylltiedig â chyflyrau fel sgitsoffrenia ac ADHD, ond hefyd effeithiau genynnau sy'n gysylltiedig â rhyw a rôl y system gyflenwi ar swyddogaeth yr ymennydd. Ond hefyd, mae gen i ddiddordeb yn agweddau cyfieithiadol y gwaith hwn.
Os oes gennych ddiddordeb mewn gwneud cais am PhD, neu am ragor o wybodaeth am fy ymchwil ôl-raddedig, cysylltwch â mi yn uniongyrchol (manylion cyswllt ar gael ar y dudalen 'Trosolwg'), neu cyflwynwch gais ffurfiol.
Ar hyn o bryd rwy'n goruchwyliwr ar gyfer:
Nina Brett "Dull model anifeiliaid cyfunol a geneteg ddynol i brofi'r rhagdybiaeth bod secretion CCN3 annormal a metaboledd calsiwm yn dylanwadu ar risg anhwylder hwyliau ôl-enedigol" (dechrau 2025)
Lara Lennon "Nodweddu model llygoden sy'n mynegi C4A cyflenwad dyneiddiol i ddeall ffactorau risg genetig ac amgylcheddol mewn sgitsoffrenia" (dechrau 2025)
Prosiectau yn y dyfodol
Nodweddu a rheoli heriau iechyd meddwl a chorfforol mewn cyflyrau croen cynhenid
Prosiectau'r gorffennol
Georgina Wren Archwilio'r materion seicolegol a ffisiolegol sy'n gysylltiedig ag ichthyosis sy'n gysylltiedig ag X (2020 i 2024)
Simona Zahova Archwilio rôl cyfwng critigol syndrom Prader-Willi mewn salwch seiciatrig a gwybyddiaeth (2017 i 2021)
Mathew Bosworth Canlyniadau swyddogaethol haploannigonolrwydd Setd1a: o feichiogrwydd i ymddygiad (2015 i 2019)
Manal Adam Epigeneteg ac anhwylderau niwro-ddatblygiadol: Nodweddu moleciwlaidd ac ymddygiadol model llygoden knockout Ehmt1/Glp (2015 i 2019 )
Laura Westacott Rheoleiddio niwroimiwnedd niwrogenesis hippocampal oedolion gan Gydran 3 a Derbynnydd Complement C3a (2012 i 2016)
Claire Dent Argraffwyd genynnau, impulsivity a chymryd risg (2010 i 2014)
Jessica Eddy Effeithiau treigladau ENU o Zfp804a ar ffenoteipiau ymddygiadol (2009 i 2013)
Mikael Mikaelsson "Rhaglennu ffetws o swyddogaeth ac ymddygiad yr ymennydd: nodweddiad ymddygiadol a moleciwlaidd o fodel dileu genynnau wedi'i argraffu â brych murine (2006 i 2010)
Rwyf hefyd wedi gweithredu fel mentor i nifer o fyfyrwyr eraill yn ysgolion Seicoleg, Meddygaeth a Biowyddorau (PSYCH oni bai bod wedi'i restru fel arall):
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Freya Shepherd (MEDIC) Sophie Waldron (MEDIC/PSYCH) Emma Clark Bhavana Gupta (MEDIC / BIOSCI) Lucy Sykes (MEDDYG) Ana Silva (MEDDYG) |
Ian Fox (BIOSCI) Natalia Galindo Riera (BIOSCI) Minika Teresa Sledziowska (BIOSCI) Amanda Hornsby (BIOSCI) Lucy Chester (MEDIC) Rachel Pass (MEDIC) |