![Anthony Isles PhD, FRSB](https://profiles-cardiff.imgix.net/attachments/2465?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Anthony Isles
(e/fe)
PhD, FRSB
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Anthony Isles
Athro, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
Trosolwg
I am a molecular and behavioural neuroscientist interested in the contribution of epigenetic mechanisms to brain and behaviour. In particular, we are investigating an intriguing family of genes, the imprinted genes, which are subject to epigenetic control acquired during development resulting in expression from one parental copy (allele) only. The research is focused on addressing what these imprinted genes are doing in the brain and how they may contribute to neurodevelopmental disorders.
Cyhoeddiad
2026
- Jones, R. et al. 2026. Investigating the contribution of the imprinted gene Asb4 to parental care. European Journal of Neuroscience 64 (5) e70655. (10.1111/ejn.70655)
- Chibnall, A. et al. 2026. Sex-specific consequences of loss-of-imprinting of the maternally expressed gene Pleckstrin Homology-Like Domain Family A Member 2 (Phlda2) on placental development and fetal growth. Biology of Sex Differences (10.1186/s13293-026-00972-z)
- Webberley, A. E. et al. 2026. Placental defects revealed by modelling PWS in mice. Disease Models & Mechanisms 19 (8) dmm052833. (10.1242/dmm.052833)
- Jones, R. A. , Higgs, M. J. and Isles, A. R. 2026. How imprinted genes shape nurturing behaviours and neural circuits. Brain, Behavior and Evolution (10.1159/000551100)
2025
- Boyanova, S. T. et al., 2025. The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders. Brain and Neuroscience Advances 2025 9. (10.1177/23982128251383973)
- Clifton, N. E. et al. 2025. Setd1a loss-of-function disrupts epigenetic regulation of ribosomal genes via altered DNA methylation. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders (10.1093/schbul/sbaf091)
2024
- Tyson, H. R. et al. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18 1374781. (10.3389/fnins.2024.1374781)
- Sansom, O. et al., 2024. Better translation via collaboration: The MRC National Mouse Genetics Network. Cell Genomics 4 (2) 100483. (10.1016/j.xgen.2023.100483)
- Bosworth, M. L. et al. 2024. Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. PLoS ONE (10.1371/journal.pone.0298717)
2023
- John, R. , Higgs, M. J. and Isles, A. R. 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 (10.1038/s41576-023-00644-3)
- Higgs, M. et al. 2023. The parenting hub of the hypothalamus is a focus of imprinted gene action. PLoS Genetics 19 (10) e1010961. (10.1371/journal.pgen.1010961)
2022
- Higgs, M. et al. 2022. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution. BMC Genomics 23 754. (10.1186/s12864-022-08986-8)
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12 438. (10.1038/s41398-022-02199-z)
- Clifton, N. et al. 2022. Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics 31 (18), pp.3095-3106. (10.1093/hmg/ddac105)
- Isles, A. R. 2022. The contribution of imprinted genes to neurodevelopmental and neuropsychiatric disorders. Translational Psychiatry 12 210. (10.1038/s41398-022-01972-4)
- Pregnolato, S. et al., 2022. Regulation of glutamate transport and neuroinflammation in a term newborn rat model of hypoxic–ischaemic brain injury. Brain and Neuroscience Advances 6 , pp.1-13. (10.1177/23982128221097568)
2021
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30 (19), pp.1863-1880. ddab154. (10.1093/hmg/ddab154)
- Zahova, S. et al. 2021. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Translational Psychiatry 11 433. (10.1038/s41398-021-01561-x)
- Clift, J. et al., 2021. Lifting the lid on impact and peer review. Brain and Neuroscience Advances 5 , pp.1-7. (10.1177/23982128211006574)
2020
- Dent, C. L. et al. 2020. Mice lacking paternal expression of imprinted 1 Grb10 are risk-takers. Genes, Brain and Behavior 19 (7) e12679. (10.1111/gbb.12679)
- Davis, B. et al. 2020. Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency. Brain and Neuroscience Advances 4 (10.1177/2398212820928647)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14 313. (10.3389/fnins.2020.00313)
- Rienecker, K. et al. 2020. Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance. Genes, Brain and Behavior 19 (1) e12571. (10.1111/gbb.12571)
2019
- Davies, J. R. et al. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28 (18), pp.3013-3023. (10.1093/hmg/ddz100)
- Pregnolato, S. et al. 2019. Glutamate Transport and Preterm Brain Injury. Frontiers in Physiology 10 417. (10.3389/fphys.2019.00417)
- Creeth, H. D. J. et al., 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53 100732. (10.1016/j.yfrne.2018.12.003)
- Tucci, V. et al., 2019. Genomic imprinting and physiological processes in mammals. Cell 176 (5), pp.952-965. (10.1016/j.cell.2019.01.043)
- Isles, A. R. , Winstanley, C. A. and Humby, T. 2019. Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications. Philosophical Transactions B: Biological Sciences 374 (1766), pp.-. 0128. (10.1098/rstb.2018.0128)
- Isles, A. R. and John, R. M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25 , pp.31-35. (10.1016/j.cobeha.2018.06.008)
2018
- Zahova, S. and Isles, A. 2018. The role of the Prader-Willi syndrome critical interval for epigenetic regulation, transcription and phenotype. Epigenomes 2 (4) 18. (10.3390/epigenomes2040018)
- Janssen, A. et al., 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4 (5), pp.354-360. (10.1192/bjo.2018.48)
- Creeth, H. D. J. et al. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16 (7) e2006599. (10.1371/journal.pbio.2006599)
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209 (1), pp.233-239. (10.1534/genetics.118.300898)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2), pp.149-157. (10.1111/gbb.12422)
- McNamara, G. , John, R. and Isles, A. 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12 28. (10.3389/fnbeh.2018.00028)
- McNamara, G. I. et al. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27 (3), pp.440-450. (10.1093/hmg/ddx412)
2017
- Adam, M. A. and Isles, A. R. 2017. EHMT1/GLP; biochemical function and association with brain disorders. Epigenomes 1 (3) 15. (10.3390/epigenomes1030015)
- Golding, D. M. et al. 2017. Paradoxical leanness in the imprinting-centre deletion mouse model for Prader–Willi syndrome. Journal of Endocrinology 232 (1), pp.123-135. (10.1530/JOE-16-0367)
2016
- McNamara, G. I. et al. 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25 (24), pp.5407-5417. (10.1093/hmg/ddw357)
- Garfield, A. S. et al., 2016. Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Molecular Brain 9 95. (10.1186/s13041-016-0277-4)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15 (8), pp.693-701. (10.1111/gbb.12316)
- Rienecker, K. , Hill, M. and Isles, A. R. 2016. Methods of epigenome editing for probing the function of genomic imprinting. Epigenomics 8 (10), pp.1389-1398. (10.2217/epi-2016-0073)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12 (5) e1005993. (10.1371/journal.pgen.1005993)
2015
- Escott-Price, V. et al. 2015. No evidence for enrichment in schizophrenia for common allelic associations at imprinted loci. PLoS ONE 10 (12), pp.-. e0144172. (10.1371/journal.pone.0144172)
- Creeth, H. et al., 2015. Programming of maternal behaviour by the placenta: A novel animal model. Psychoneuroendocrinology 61 , pp.4. PS1.1.3. (10.1016/j.psyneuen.2015.07.397)
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4), pp.2105-2113. (10.1111/ejn.12972)
- Isles, A. R. 2015. 15q maternal duplication and neurodevelopmental disorders; UBE3A is the key. Human Mutation 36 (7), pp.iii. (10.1002/humu.22656)
- Isles, A. R. 2015. Neural and behavioral epigenetics; what it is, and what is hype. Genes, Brain and Behavior 14 (1), pp.64-72. (10.1111/gbb.12184)
- Davies, J. R. et al. 2015. Behavioural effects of imprinted genes. Current Opinion in Behavioral Sciences 2 , pp.28-33. (10.1016/j.cobeha.2014.07.008)
2014
- Dent, C. L. and Isles, A. R. 2014. An Overview of measuring impulsive behavior in mice. Current Protocols in Mouse Biology 4 (2), pp.35-45. (10.1002/9780470942390.mo140015)
- Dent, C. , Isles, A. R. and Humby, T. 2014. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience 39 (4), pp.520-530. (10.1111/ejn.12430)
- Rees, E. et al. 2014. Analysis of copy number variations at 15 schizophrenia-associated loci. British Journal of Psychiatry 204 (2), pp.108-114. (10.1192/bjp.bp.113.131052)
- Cowley, M. et al., 2014. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biology 12 (2), pp.e1001799. (10.1371/journal.pbio.1001799)
- Davis, B. A. and Isles, A. R. 2014. Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent?. European Journal of Neuroscience 39 (11), pp.1933-1942. (10.1111/ejn.12607)
- Dent, C. and Isles, A. R. 2014. Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10. Mammalian Genome 25 (1-2), pp.87-93. (10.1007/s00335-013-9472-0)
- McNamara, G. and Isles, A. R. 2014. Influencing the social group: the role of imprinted genes. Advances in Genetics 86 , pp.107-134. (10.1016/B978-0-12-800222-3.00006-1)
2013
- McNamara, G. I. and Isles, A. R. 2013. Dosage-sensitivity of imprinted genes expressed in the brain: 15q11–q13 and neuropsychiatric illness. Biochemical Society Transactions 41 (3), pp.721-726. (10.1042/BST20130008)
- Relkovic, D. and Isles, A. R. 2013. Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome. Brain Research Bulletin 92 , pp.41-48. (10.1016/j.brainresbull.2011.09.009)
2012
- Relkovic, D. et al. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126 (3), pp.488-492. (10.1037/a0028155)
2011
- Garfield, A. S. et al. 2011. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 469 (7331), pp.534-538. (10.1038/nature09651)
- Ingason, A. et al., 2011. Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry 168 (4), pp.408-417. (10.1176/appi.ajp.2010.09111660)
- Isles, A. R. 2011. Genomic imprinting; the cost of mother's care. Bioessays 33 (12), pp.924-926. (10.1002/bies.201100115)
2010
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31 (1), pp.156-164. (10.1111/j.1460-9568.2009.07048.x)
- Hinton, E. C. et al. 2010. Excessive appetitive arousal in Prader–Willi syndrome. Appetite 54 (1), pp.225-228. (10.1016/j.appet.2009.12.002)
2009
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18 (12), pp.2140-2148. (10.1093/hmg/ddp137)
- Isles, A. R. 2009. Evolution of genomic imprinting in humans: Does bipedalism have a role?. Trends in Genetics 25 (11), pp.495-500. (10.1016/j.tig.2009.09.010)
2008
- Davies, W. and Isles, A. R. 2008. Genomic imprinting and disorders of the social brain; shades of grey rather than black and white. Behavioral and Brain Sciences 31 (3), pp.265-266. (10.1017/S0140525X08004263)
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
- Doe, C. et al., 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22 (s2), pp.125. (10.1111/j.1472-8206.2008.00601.x)
- Isles, A. R. 2008. Feel the heat: epigenetic coding of thermotolerance in the chick (Commentary on Yossifoffet al.). European Journal of Neuroscience 28 (11), pp.2266. (10.1111/j.1460-9568.2008.06544.x)
- Isles, A. R. and Wilkinson, L. S. 2008. Epigenetics: what is it and why is it important to mental disease?. British Medical Bulletin 85 (1), pp.35-45. (10.1093/bmb/ldn004)
2007
- Lambourne, S. L. et al., 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16 (14), pp.1708-1719. (10.1093/hmg/ddm119)
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Wilkinson, L. S. , Davies, W. and Isles, A. R. 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11), pp.832-843. (10.1038/nrn2235)
2006
- Davies, W. et al. 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1), pp.35-44. (10.1002/bies.20341)
- Isles, A. R. , Davies, W. and Wilkinson, L. S. 2006. Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1476), pp.2229-2237. (10.1098/rstb.2006.1942)
- Isles, A. R. and Humby, T. 2006. Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research 50 (5), pp.318-325. (10.1111/j.1365-2788.2006.00843.x)
2005
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Plagge, A. et al., 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25 (8), pp.3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Isles, A. R. and Holland, A. J. 2005. Imprinted genes and mother-offspring interactions. Early Human Development 81 (1), pp.73-77.
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2005. Imprinted gene expression in the brain. Neuroscience & Biobehavioral Reviews 29 (3), pp.421-430. (10.1016/j.neubiorev.2004.11.007)
- Isles, A. R. et al. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22 (4), pp.997-1000. (10.1111/j.1460-9568.2005.04265.x)
2004
- Isles, A. R. et al. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24 (30), pp.6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
- Isles, A. R. et al. 2004. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Human Molecular Genetics 13 (17), pp.1849-1855. (10.1093/hmg/ddh203)
2003
- Davies, W. et al., 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17 (S), pp.A70.
- Isles, A. R. , Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170 (4), pp.376-382. (10.1007/s00213-003-1551-6)
2002
- Isles, A. R. and Wilkinson, L. S. 2002. Genomic imprinting, hormones and behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426.
- Isles, A. R. and Wilkinson, L. S. 2002. Neuroendocrinology Briefings 16: Genomic Imprinting, Hormones and Behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426. (10.1046/j.1365-2826.2002.00445.x)
- Isles, A. R. et al. 2002. A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice. Proceedings of the Royal Society B: Biological Sciences 269 (1492), pp.665-670. (10.1098/rspb.2001.1911)
2001
- Isles, A. R. 2001. Reversible regulation of mouse genes. Trends Genet 17 (8), pp.441-441.
- Isles, A. R. 2001. When is a clone not a clone?. Trends Genet 17 (8), pp.441-441.
- Isles, A. R. et al. 2001. Genetic imprinting: urinary odour preferences in mice. Nature 409 (6822), pp.783-784. (10.1038/35057323)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2001. Imprinted genes and mental dysfunction. Annals of Medicine 33 (6), pp.428-436. (10.3109/07853890108995956)
- Isles, A. R. et al. 2001. Conditional ablation of neurones in transgenic mice. Journal of Neurobiology 47 (3), pp.183-193. (10.1002/neu.1026)
2000
- Isles, A. R. and Wilkinson, L. S. 2000. Imprinted genes, cognition and behaviour. Trends in Cognitive Sciences 4 (8), pp.309-318. (10.1016/S1364-6613(00)01504-7)
Adrannau llyfrau
- Davies, W. et al. 2008. What are imprinted genes doing in the brain?. In: Wilkins, J. F. ed. Genomic Imprinting. Advances in experimental medicine and biology Vol. 626.Berlin: Springer. , pp.62-70. (10.1007/978-0-387-77576-0_5)
Erthyglau
- Jones, R. et al. 2026. Investigating the contribution of the imprinted gene Asb4 to parental care. European Journal of Neuroscience 64 (5) e70655. (10.1111/ejn.70655)
- Chibnall, A. et al. 2026. Sex-specific consequences of loss-of-imprinting of the maternally expressed gene Pleckstrin Homology-Like Domain Family A Member 2 (Phlda2) on placental development and fetal growth. Biology of Sex Differences (10.1186/s13293-026-00972-z)
- Webberley, A. E. et al. 2026. Placental defects revealed by modelling PWS in mice. Disease Models & Mechanisms 19 (8) dmm052833. (10.1242/dmm.052833)
- Jones, R. A. , Higgs, M. J. and Isles, A. R. 2026. How imprinted genes shape nurturing behaviours and neural circuits. Brain, Behavior and Evolution (10.1159/000551100)
- Boyanova, S. T. et al., 2025. The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders. Brain and Neuroscience Advances 2025 9. (10.1177/23982128251383973)
- Clifton, N. E. et al. 2025. Setd1a loss-of-function disrupts epigenetic regulation of ribosomal genes via altered DNA methylation. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders (10.1093/schbul/sbaf091)
- Tyson, H. R. et al. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18 1374781. (10.3389/fnins.2024.1374781)
- Sansom, O. et al., 2024. Better translation via collaboration: The MRC National Mouse Genetics Network. Cell Genomics 4 (2) 100483. (10.1016/j.xgen.2023.100483)
- Bosworth, M. L. et al. 2024. Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. PLoS ONE (10.1371/journal.pone.0298717)
- John, R. , Higgs, M. J. and Isles, A. R. 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 (10.1038/s41576-023-00644-3)
- Higgs, M. et al. 2023. The parenting hub of the hypothalamus is a focus of imprinted gene action. PLoS Genetics 19 (10) e1010961. (10.1371/journal.pgen.1010961)
- Higgs, M. et al. 2022. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution. BMC Genomics 23 754. (10.1186/s12864-022-08986-8)
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12 438. (10.1038/s41398-022-02199-z)
- Clifton, N. et al. 2022. Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function. Human Molecular Genetics 31 (18), pp.3095-3106. (10.1093/hmg/ddac105)
- Isles, A. R. 2022. The contribution of imprinted genes to neurodevelopmental and neuropsychiatric disorders. Translational Psychiatry 12 210. (10.1038/s41398-022-01972-4)
- Pregnolato, S. et al., 2022. Regulation of glutamate transport and neuroinflammation in a term newborn rat model of hypoxic–ischaemic brain injury. Brain and Neuroscience Advances 6 , pp.1-13. (10.1177/23982128221097568)
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30 (19), pp.1863-1880. ddab154. (10.1093/hmg/ddab154)
- Zahova, S. et al. 2021. Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia. Translational Psychiatry 11 433. (10.1038/s41398-021-01561-x)
- Clift, J. et al., 2021. Lifting the lid on impact and peer review. Brain and Neuroscience Advances 5 , pp.1-7. (10.1177/23982128211006574)
- Dent, C. L. et al. 2020. Mice lacking paternal expression of imprinted 1 Grb10 are risk-takers. Genes, Brain and Behavior 19 (7) e12679. (10.1111/gbb.12679)
- Davis, B. et al. 2020. Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency. Brain and Neuroscience Advances 4 (10.1177/2398212820928647)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14 313. (10.3389/fnins.2020.00313)
- Rienecker, K. et al. 2020. Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance. Genes, Brain and Behavior 19 (1) e12571. (10.1111/gbb.12571)
- Davies, J. R. et al. 2019. Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition. Human Molecular Genetics 28 (18), pp.3013-3023. (10.1093/hmg/ddz100)
- Pregnolato, S. et al. 2019. Glutamate Transport and Preterm Brain Injury. Frontiers in Physiology 10 417. (10.3389/fphys.2019.00417)
- Creeth, H. D. J. et al., 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53 100732. (10.1016/j.yfrne.2018.12.003)
- Tucci, V. et al., 2019. Genomic imprinting and physiological processes in mammals. Cell 176 (5), pp.952-965. (10.1016/j.cell.2019.01.043)
- Isles, A. R. , Winstanley, C. A. and Humby, T. 2019. Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications. Philosophical Transactions B: Biological Sciences 374 (1766), pp.-. 0128. (10.1098/rstb.2018.0128)
- Isles, A. R. and John, R. M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25 , pp.31-35. (10.1016/j.cobeha.2018.06.008)
- Zahova, S. and Isles, A. 2018. The role of the Prader-Willi syndrome critical interval for epigenetic regulation, transcription and phenotype. Epigenomes 2 (4) 18. (10.3390/epigenomes2040018)
- Janssen, A. et al., 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4 (5), pp.354-360. (10.1192/bjo.2018.48)
- Creeth, H. D. J. et al. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16 (7) e2006599. (10.1371/journal.pbio.2006599)
- Dent, C. L. et al. 2018. Impulsive choice in mice lacking paternal expression of Grb10 suggests intragenomic conflict in behavior. Genetics 209 (1), pp.233-239. (10.1534/genetics.118.300898)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2), pp.149-157. (10.1111/gbb.12422)
- McNamara, G. , John, R. and Isles, A. 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12 28. (10.3389/fnbeh.2018.00028)
- McNamara, G. I. et al. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27 (3), pp.440-450. (10.1093/hmg/ddx412)
- Adam, M. A. and Isles, A. R. 2017. EHMT1/GLP; biochemical function and association with brain disorders. Epigenomes 1 (3) 15. (10.3390/epigenomes1030015)
- Golding, D. M. et al. 2017. Paradoxical leanness in the imprinting-centre deletion mouse model for Prader–Willi syndrome. Journal of Endocrinology 232 (1), pp.123-135. (10.1530/JOE-16-0367)
- McNamara, G. I. et al. 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25 (24), pp.5407-5417. (10.1093/hmg/ddw357)
- Garfield, A. S. et al., 2016. Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Molecular Brain 9 95. (10.1186/s13041-016-0277-4)
- Dent, C. et al. 2016. Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior 15 (8), pp.693-701. (10.1111/gbb.12316)
- Rienecker, K. , Hill, M. and Isles, A. R. 2016. Methods of epigenome editing for probing the function of genomic imprinting. Epigenomics 8 (10), pp.1389-1398. (10.2217/epi-2016-0073)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12 (5) e1005993. (10.1371/journal.pgen.1005993)
- Escott-Price, V. et al. 2015. No evidence for enrichment in schizophrenia for common allelic associations at imprinted loci. PLoS ONE 10 (12), pp.-. e0144172. (10.1371/journal.pone.0144172)
- Creeth, H. et al., 2015. Programming of maternal behaviour by the placenta: A novel animal model. Psychoneuroendocrinology 61 , pp.4. PS1.1.3. (10.1016/j.psyneuen.2015.07.397)
- Davies, J. R. et al. 2015. Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome. European Journal of Neuroscience 42 (4), pp.2105-2113. (10.1111/ejn.12972)
- Isles, A. R. 2015. 15q maternal duplication and neurodevelopmental disorders; UBE3A is the key. Human Mutation 36 (7), pp.iii. (10.1002/humu.22656)
- Isles, A. R. 2015. Neural and behavioral epigenetics; what it is, and what is hype. Genes, Brain and Behavior 14 (1), pp.64-72. (10.1111/gbb.12184)
- Davies, J. R. et al. 2015. Behavioural effects of imprinted genes. Current Opinion in Behavioral Sciences 2 , pp.28-33. (10.1016/j.cobeha.2014.07.008)
- Dent, C. L. and Isles, A. R. 2014. An Overview of measuring impulsive behavior in mice. Current Protocols in Mouse Biology 4 (2), pp.35-45. (10.1002/9780470942390.mo140015)
- Dent, C. , Isles, A. R. and Humby, T. 2014. Measuring risk-taking in mice: balancing the risk between seeking reward and danger. European Journal of Neuroscience 39 (4), pp.520-530. (10.1111/ejn.12430)
- Rees, E. et al. 2014. Analysis of copy number variations at 15 schizophrenia-associated loci. British Journal of Psychiatry 204 (2), pp.108-114. (10.1192/bjp.bp.113.131052)
- Cowley, M. et al., 2014. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biology 12 (2), pp.e1001799. (10.1371/journal.pbio.1001799)
- Davis, B. A. and Isles, A. R. 2014. Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent?. European Journal of Neuroscience 39 (11), pp.1933-1942. (10.1111/ejn.12607)
- Dent, C. and Isles, A. R. 2014. Brain-expressed imprinted genes and adult behaviour: the example of Nesp and Grb10. Mammalian Genome 25 (1-2), pp.87-93. (10.1007/s00335-013-9472-0)
- McNamara, G. and Isles, A. R. 2014. Influencing the social group: the role of imprinted genes. Advances in Genetics 86 , pp.107-134. (10.1016/B978-0-12-800222-3.00006-1)
- McNamara, G. I. and Isles, A. R. 2013. Dosage-sensitivity of imprinted genes expressed in the brain: 15q11–q13 and neuropsychiatric illness. Biochemical Society Transactions 41 (3), pp.721-726. (10.1042/BST20130008)
- Relkovic, D. and Isles, A. R. 2013. Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome. Brain Research Bulletin 92 , pp.41-48. (10.1016/j.brainresbull.2011.09.009)
- Relkovic, D. et al. 2012. Enhanced appetitive learning and reversal learning in a mouse model for Prader-Willi syndrome. Behavioral Neuroscience 126 (3), pp.488-492. (10.1037/a0028155)
- Garfield, A. S. et al. 2011. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 469 (7331), pp.534-538. (10.1038/nature09651)
- Ingason, A. et al., 2011. Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry 168 (4), pp.408-417. (10.1176/appi.ajp.2010.09111660)
- Isles, A. R. 2011. Genomic imprinting; the cost of mother's care. Bioessays 33 (12), pp.924-926. (10.1002/bies.201100115)
- Relkovic, D. et al. 2010. Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader–Willi syndrome. European Journal of Neuroscience 31 (1), pp.156-164. (10.1111/j.1460-9568.2009.07048.x)
- Hinton, E. C. et al. 2010. Excessive appetitive arousal in Prader–Willi syndrome. Appetite 54 (1), pp.225-228. (10.1016/j.appet.2009.12.002)
- Doe, C. M. et al. 2009. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Human Molecular Genetics 18 (12), pp.2140-2148. (10.1093/hmg/ddp137)
- Isles, A. R. 2009. Evolution of genomic imprinting in humans: Does bipedalism have a role?. Trends in Genetics 25 (11), pp.495-500. (10.1016/j.tig.2009.09.010)
- Davies, W. and Isles, A. R. 2008. Genomic imprinting and disorders of the social brain; shades of grey rather than black and white. Behavioral and Brain Sciences 31 (3), pp.265-266. (10.1017/S0140525X08004263)
- Doe, C. et al., 2008. 5-HT2CR pre-RNA editing, alternate splicing and function in a mouse model of Prader-Willi syndrome. Fundamental & Clinical Pharmacology 22 (s2), pp.125. (10.1111/j.1472-8206.2008.00601.x)
- Isles, A. R. 2008. Feel the heat: epigenetic coding of thermotolerance in the chick (Commentary on Yossifoffet al.). European Journal of Neuroscience 28 (11), pp.2266. (10.1111/j.1460-9568.2008.06544.x)
- Isles, A. R. and Wilkinson, L. S. 2008. Epigenetics: what is it and why is it important to mental disease?. British Medical Bulletin 85 (1), pp.35-45. (10.1093/bmb/ldn004)
- Lambourne, S. L. et al., 2007. Impairments in impulse control in animal models transgenic for the human FTPD-17 tauV337M mutation are exacerbated by age. Human Molecular Genetics 16 (14), pp.1708-1719. (10.1093/hmg/ddm119)
- Davies, W. et al. 2007. X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biological psychiatry 61 (12), pp.1351-1360. (10.1016/j.biopsych.2006.08.011)
- Davies, W. et al. 2007. What are imprinted genes doing in the brain? [Review]. Epigenetics 2 (4), pp.201-206. (10.4161/epi.2.4.5379)
- Wilkinson, L. S. , Davies, W. and Isles, A. R. 2007. Genomic imprinting effects on brain development and function. Nature Reviews Neuroscience 8 (11), pp.832-843. (10.1038/nrn2235)
- Davies, W. et al. 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1), pp.35-44. (10.1002/bies.20341)
- Isles, A. R. , Davies, W. and Wilkinson, L. S. 2006. Genomic imprinting and the social brain. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1476), pp.2229-2237. (10.1098/rstb.2006.1942)
- Isles, A. R. and Humby, T. 2006. Modes of imprinted gene action in learning disability. Journal of Intellectual Disability Research 50 (5), pp.318-325. (10.1111/j.1365-2788.2006.00843.x)
- Davies, W. et al. 2005. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Nature Genetics 37 (6), pp.625-629. (10.1038/ng1577)
- Plagge, A. et al., 2005. Imprinted Nesp55 influences behavioral reactivity to novel environments. Molecular and Cellular Biology 25 (8), pp.3019-3026. (10.1128/MCB.25.8.3019-3026.2005)
- Isles, A. R. and Holland, A. J. 2005. Imprinted genes and mother-offspring interactions. Early Human Development 81 (1), pp.73-77.
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2005. Imprinted gene expression in the brain. Neuroscience & Biobehavioral Reviews 29 (3), pp.421-430. (10.1016/j.neubiorev.2004.11.007)
- Isles, A. R. et al. 2005. An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. European Journal of Neuroscience 22 (4), pp.997-1000. (10.1111/j.1460-9568.2005.04265.x)
- Isles, A. R. et al. 2004. Common genetic effects on variation in impulsivity and activity in mice. Journal of Neuroscience 24 (30), pp.6733-6740. (10.1523/JNEUROSCI.1650-04.2004)
- Isles, A. R. et al. 2004. Effects on fear reactivity in XO mice are due to haploinsufficiency of a non-PAR X gene: implications for emotional function in Turner's syndrome. Human Molecular Genetics 13 (17), pp.1849-1855. (10.1093/hmg/ddh203)
- Davies, W. et al., 2003. Evidence for X-linked imprinted gene functioning on cognition in mice; a possible neurochemical basis, and implications for cognitive sexual dimorphism [Abstract]. Journal of Psychopharmacology 17 (S), pp.A70.
- Isles, A. R. , Humby, T. and Wilkinson, L. S. 2003. Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology 170 (4), pp.376-382. (10.1007/s00213-003-1551-6)
- Isles, A. R. and Wilkinson, L. S. 2002. Genomic imprinting, hormones and behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426.
- Isles, A. R. and Wilkinson, L. S. 2002. Neuroendocrinology Briefings 16: Genomic Imprinting, Hormones and Behaviour. Journal of Neuroendocrinology 14 (5), pp.425-426. (10.1046/j.1365-2826.2002.00445.x)
- Isles, A. R. et al. 2002. A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice. Proceedings of the Royal Society B: Biological Sciences 269 (1492), pp.665-670. (10.1098/rspb.2001.1911)
- Isles, A. R. 2001. Reversible regulation of mouse genes. Trends Genet 17 (8), pp.441-441.
- Isles, A. R. 2001. When is a clone not a clone?. Trends Genet 17 (8), pp.441-441.
- Isles, A. R. et al. 2001. Genetic imprinting: urinary odour preferences in mice. Nature 409 (6822), pp.783-784. (10.1038/35057323)
- Davies, W. , Isles, A. R. and Wilkinson, L. S. 2001. Imprinted genes and mental dysfunction. Annals of Medicine 33 (6), pp.428-436. (10.3109/07853890108995956)
- Isles, A. R. et al. 2001. Conditional ablation of neurones in transgenic mice. Journal of Neurobiology 47 (3), pp.183-193. (10.1002/neu.1026)
- Isles, A. R. and Wilkinson, L. S. 2000. Imprinted genes, cognition and behaviour. Trends in Cognitive Sciences 4 (8), pp.309-318. (10.1016/S1364-6613(00)01504-7)
Ymchwil
Mae gan fy ngrŵp ddiddordeb mewn cyfraniad mecanweithiau epigenetig i'r ymennydd ac ymddygiad. Yn benodol, rydym yn ymchwilio i deulu diddorol o enynnau, y genynnau argraffedig, sy'n destun rheolaeth epigenetig a gafwyd yn ystod datblygiad sy'n arwain at fynegiant o un copi rhiant (alel) yn unig. Mae'r ymchwil yn canolbwyntio ar fynd i'r afael â'r hyn y mae'r genynnau argraffedig hyn yn ei wneud yn yr ymennydd a sut y gallant gyfrannu at anhwylderau niwro-ddatblygiadol. Mae ymchwil ddiweddar mewn cydweithrediad â'r Athro Rosalind John (Prifysgol Caerdydd) yn ymchwilio i a all newidiadau ym mynegiant y brych genynnau wedi'u hargraffu ddylanwadu ar ymddygiad mamau a chanlyniadau plant diweddarach.
Mae gennyf ddiddordeb hefyd mewn datblygu a defnyddio modelau cyn-glinigol ar gyfer anhwylderau niwrodatblygiadol a niwroseiciatrig, ac ar hyn o bryd rwy'n arwain clwstwr MURIDAE o fewn Rhwydwaith Genetig Llygoden Cenedlaethol UKRI:MRC.
Mae ein gwaith yn gofyn am ddull amlddisgyblaethol er mwyn archwilio agweddau ar ymddygiad, niwrobioleg a geneteg foleciwlaidd. Rydym yn archwilio ffenoteipiau ymddygiadol yn bennaf mewn modelau cnofilod ac yn defnyddio technegau moleciwlaidd ar gyfer mynd i'r afael â mynegiant genynnau a rheoleiddio epigenetig y genom (addasu histon a methylation DNA).
Meysydd prosiect ymchwil cyfredol
- Genynnau, ymennydd ac ymddygiad wedi'u hargraffu
- Cydlynu canlyniadau placenta, ymennydd y fam, ac epil
- Datblygiad ymennydd ac ymddygiad mewn modelau llygoden genetig ar gyfer sgitsoffrenia
Cyllid Ymchwil
Gwobr Iechyd Meddwl Wellcome (2025-2030) - "Y glud sy'n dal y darnau gyda'i gilydd: datgloi iechyd gwybyddol mewn anhwylderau seicotig"
UKRI:Cyngor Ymchwil Feddygol (2022-2027) - "MURIDAE: Modalities for Understanding, Recording and Integrating Data Across Early Life"
Ymddiriedolaeth Leverhulme, grant prosiect (2022-2026) - "Cyfraniad genynnau wedi'u mynegi gan fam i ymddygiad rhieni"
Addysgu
Israddedig
Goruchwyliwr adolygiad llenyddiaeth Blwyddyn 1 SCC
Modiwl iBSc seicoleg 'Sail wyddonol meddygaeth seicolegol' (ME3085)
Tiwtor personol i fyfyrwyr sy'n dilyn y rhaglen MBBCh
Ôl-raddedig
Arweinydd y modiwl Niwrowyddoniaeth MSc
Darlithydd ar Genomeg Clefydau Etifeddol Cyffredin a Phrin (MET 950, Meddygaeth Genomeg ac MSc Gofal Iechyd)
Bywgraffiad
Education and qualifications
- 2000: PhD (Zoology) University of Cambridge, Cambridge, UK
- 1994: BSc Zoology & Genetics, University of Sheffield, UK
Career overview
- 2006 - present: Professor, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK
- 2003 - 2008 Beebe Ttrust Research Fellow, Department of Psychiatry, University of Cambridge, Cambridge, UK
- 1999 - 2003 Post-doctoral researcher, The Babraham Institute, Cambridge, UK
- 1994 - 1995 ESF Trainee technician, Department of Genetics, Leicester University, UK
Anrhydeddau a dyfarniadau
- Cymrawd y Royal Scoiety of Biology
Safleoedd academaidd blaenorol
- 2006 - presennol: Athro, Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig, Prifysgol Caerdydd, Caerdydd, y DU
- 2003 - 2008 Cymrawd Ymchwil Ymddiriedolaeth Beebe, Adran Seiciatreg, Prifysgol Caergrawnt, Caergrawnt, DU
- 1999 - 2003 Ymchwilydd ôl-ddoethurol, Sefydliad Babraham , Caergrawnt, UK
- 1994 - 1995 ESF Technegydd dan hyfforddiant, Adran Geneteg, Prifysgol Caerlŷr, UK
Pwyllgorau ac adolygu
Mewnol
- Cynrychiolydd MEDIC, DENTL & PHRMY ar y Pwyllgor Safonau Biolegol (2022-presennol)
- Arweinydd, Thema Niwrowyddoniaeth ac Iechyd Meddwl, rhaglen hyfforddiant doethurol GW4 MRC BioMed (2015-2022)
- Cyfarwyddwr rhaglen PhD Niwrowyddoniaeth Integreiddiol Ymddiriedolaeth Wellcome (2014-2024)
Allanol
- Aelod o Grŵp Cynghori Darganfod Gwyddorau Hymennydd ac Ymddygiad Wellcome (2023-presennol)
- Aelod o Fwrdd Golygyddol, Trafodion Athronyddol y Gymdeithas Frenhinol B (2020-2025)
- Golygydd Cyswllt, Frontiers in Developmental Epigenetics (2017-2024)
- Aelod o'r Bwrdd Golygyddol, Genes Brain and Behavior (2017-presennol)
- Aelod o'r Bwrdd Golygyddol, Brain and Neuroscience Advances (2017-presennol)
- Ymddiriedolwr, Cymdeithas Niwrowyddoniaeth Prydain (2017-2022)
- Aelod o banel GEMM y Cyngor Ymchwil Feddygol (2016-2022)
- Golygydd Cyswllt, Cyfnodolyn Niwrowyddorau Ewropeaidd (2008-2020)
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Isadora Sinha
Prosiectau'r gorffennol
Myfyrwyr PhD diweddar (goruchwyliwr arweiniol)
- Dr Matthew Higgs; Traethawd ymchwil PhD Dull Lefel Systemau i Ganfod a dilysu genynnau sydd wedi'u hargraffu sy'n ymwneud â gofal rhieni a'r cylchedwaith niwral cysylltiedig; Enillydd Gwobr Bruce Cattanach Cymdeithas Geneteg 2024
- Dr Simona Zahova; Traethawd PhD Archwilio rôl syndrom Prader-Willi cyfwng critigol mewn salwch a gwybyddiaeth seiciatrig
- Dr Matthew Bosworth; PhD thesis Canlyniadau swyddogaethol haploinsufficiency Set1da; o ystumio i ymddygiad
- Dr Manal Adam; Traethawd PhD Epigeneteg ac anhwylderau niwroddatblygiadol: nodweddu moleciwlaidd ac ymddygiadol llygoden knockout Ehmt1 / Glp
- Dr Kira Rienecker; Traethawd PhD Paternal Grb10 mewn ymennydd ac ymddygiad
Ymgysylltu
Mae'n hanfodol bod gwyddonwyr yn ceisio esbonio eu maes ymchwil i leygoedd cynulleidfaoedd, ac yn wir, lle bo hynny'n bosibl, bod ein hymchwil yn cael ei lywio gan ein rhyngweithio â'r cyhoedd yn gyffredinol. Rwy'n ymgymryd â gweithgareddau ymgysylltu'n rheolaidd ac wedi siarad mewn digwyddiadau fel Pint of Science, Caffi Athroniaeth Caerdydd, a dathliadau Canmlwyddiant MRC yn BayArt.
Rwyf hefyd yn awyddus i hyrwyddo niwrowyddoniaeth ac roeddwn yn Ymddiriedolwr Cymdeithas Niwroscaince Prydain o 2017-2022, lle glanheais eu cylchgrawn cymdeithas, helpu gyda phrosiectau BNA Credible Neuroscience a fi oedd y prif siaradwr mewn sesiwn weminar o'r enw 'Gyrfaoedd mewn niwrowyddoniaeth (a thu hwnt!) ' a fynychwyd gan ymchwilwyr gyrfa gynnar o bob cwr o'r byd.
Yn ychwanegol, rwyf wedi trafod fy ymchwil gyda rhieni a gofalwyr unigolion â syndrom Prader-Willi mewn digwyddiadau fel Arweinyddiaeth IPWSO ECHO®, ac wedi recordio podlediadau ar gyfer Natur a'r Gymdeithas Biocemegol yn egluro fy ymchwil. Mae ein gwaith hefyd wedi cael sylw mewn erthyglau newyddion yn y Smithsonian, Scientific American a hyd yn oed y Daily Mail.
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Contact Details
[email protected]
+44 29206 88467
Adeilad Hadyn Ellis, Ystafell 2.48, Heol Maendy, Caerdydd, CF24 4HQ
+44 29206 88467
Adeilad Hadyn Ellis, Ystafell 2.48, Heol Maendy, Caerdydd, CF24 4HQ
Themâu ymchwil
Arbenigeddau
- Niwrowyddoniaeth ymddygiadol
- Bioleg foleciwlaidd
- Niwroddatblygiad
