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Yr Athro Ros John
Cyfarwyddwr Ymchwil, Athro
Ysgol y Biowyddorau
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Trosolwg ymchwil
Mae fy ymchwil yn ceisio mynd i'r afael ag un o'r cwestiynau mwyaf heriol a sylfaenol bwysig ym maes iechyd pobl, sef sut i fanteisio i'r eithaf ar y siawns o feichiogrwydd iach a llwyddiannus. Mae gofal sy'n gysylltiedig â beichiogrwydd yn costio tua £5.8 biliwn y flwyddyn i'r GIG, ond dim ond 2.4% o'r holl gyllid ymchwil iechyd uniongyrchol, nad yw'n ddiwydiant sy'n cael ei wario ar ymchwil sy'n gysylltiedig â beichiogrwydd (adroddiad RAND, 2020). Mae hyn yn nodi mai ymchwil beichiogrwydd yw un o'r meysydd ymchwil sydd wedi'u tanariannu fwyaf yn y DU. Ac eto, dyma lle mae iechyd pobl yn dechrau a lle gallwn wneud y newidiadau mwyaf effeithiol i wella iechyd nid yn unig y fam ond hefyd ar gyfer cenedlaethau'r dyfodol. Mae fy ngrwpiau ymchwil yn defnyddio data carfan ddynol (The Grown in Wales Study) a systemau arbrofol i archwilio sut mae adfyd cynenedigol, yr amcangyfrifir ei fod yn effeithio ar fwy na hanner holl feichiogrwydd y DU, yn peryglu twf ffetws ac iechyd meddwl mamol, ac yn rhaglennu rhai o'r clefydau mwyaf cyffredin a threiddiol sy'n effeithio ar boblogaethau dynol.
Rolau
- Cyfarwyddwr Ymchwil
- Arweinydd Tîm Academaidd
Cyhoeddiad
2024
- John, R. M. 2024. The placenta as a neuroendocrine organ. In: Brunton, P. J. and Grattan, D. R. eds. Neuroendocrine Regulation of Mammalian Pregnancy and Lactation. Springer, pp. 21-63., (10.1007/978-3-031-51138-7_2)
- Prodani, C. et al. 2024. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific Reports 14(1), article number: 8528. (10.1038/s41598-024-59083-7)
- Tyson, H. R., Harrison, D. J., Higgs, M. J., Isles, A. R. and John, R. M. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18, article number: 1374781. (10.3389/fnins.2024.1374781)
2023
- John, R., Higgs, M. J. and Isles, A. R. 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 (10.1038/s41576-023-00644-3)
- Higgs, M., Webberley, A., Allan, A., Talat, M., John, R. and Isles, A. 2023. The parenting hub of the hypothalamus is a focus of imprinted gene action. PLoS Genetics 19(10), article number: e1010961. (10.1371/journal.pgen.1010961)
- Burgess, R. et al. 2023. A quantitative evaluation of thin slice sampling for parent-infant interactions. Journal of Nonverbal Behavior 47, pp. 117-210. (10.1007/s10919-022-00420-7)
2022
- Higgs, M., Hill, M., John, R. and Isles, A. 2022. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution. BMC Genomics 23, article number: 754. (10.1186/s12864-022-08986-8)
- Garay, S. M., Sumption, L. and John, R. 2022. Prenatal health behaviours as predictors of human placental lactogen levels. Frontiers in Endocrinology 13, article number: 946539. (10.3389/fendo.2022.946539)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150, article number: 47-53. (10.1016/j.jpsychires.2022.03.009)
- Van de Pette, M. et al. 2022. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nature Communications 13(1), article number: 2464. (10.1038/s41467-022-30022-2)
- John, R. M. 2022. In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring. Experimental Physiology 107(5), pp. 398-404. (10.1113/EP089916)
- John, R. M., Lefebvre, L. and Surani, M. A. 2022. Genomic imprinting: a paradigm for epigenetics of human diseases. In: Michels, K. B. ed. Epigenetic Epidemiology (2nd Edition). Springer, Cham, pp. 171-212., (10.1007/978-3-030-94475-9_8)
2021
- Savory, N. A., Hannigan, B., John, R. M., Sanders, J. and Garay, S. M. 2021. Prevalence and predictors of poor mental health among pregnant women in Wales using a cross-sectional survey. Midwifery 103, article number: 103103. (10.1016/j.midw.2021.103103)
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30(19), pp. 1863-1880., article number: ddab154. (10.1093/hmg/ddab154)
- Garcia Martin, I., Penketh, R. J. A., Garay, S. M., Jones, R. E., Grimstead, J. W., Baird, D. M. and John, R. M. 2021. Symptoms of prenatal depression associated with shorter telomeres in female placenta. International Journal of Molecular Sciences 22(14), article number: 7458. (10.3390/ijms22147458)
- Dingsdale, H. et al. 2021. The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor. Translational Psychiatry 11(1), article number: 62. (10.1038/s41398-020-01176-8)
- Garay, S., Sumption, L., Pearson, R. and John, R. 2021. Risk factors for excessive gestational weight gain in a UK population: A biopsychosocial model approach. BMC Pregnancy and Childbirth 21, article number: 43. (10.1186/s12884-020-03519-1)
2020
- Creeth, H. D. J. and John, R. M. 2020. The placental programming hypothesis: placental endocrine insufficiency and the co-occurrence of low birth weight and maternal mood disorders. Placenta 98, pp. 52-59. (10.1016/j.placenta.2020.03.011)
- Sumption, L. A., Garay, S. M. and John, R. M. 2020. Low serum placental lactogen at term is associated with postnatal symptoms of depression and anxiety in women delivering female infants. Psychoneuroendocrinology 116, article number: 104655. (10.1016/j.psyneuen.2020.104655)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14, article number: 313. (10.3389/fnins.2020.00313)
- Savory, K. et al. 2020. Prenatal symptoms of anxiety and depression associated with sex differences in both maternal perceptions of one year old infant temperament and researcher observed infant characteristics. Journal of Affective Disorders 264, pp. 383-392. (10.1016/j.jad.2019.11.057)
2019
- Garay, S. M., Savory, K. A., Sumption, L. A., Penketh, R. J., Jones, I. R., Janssen, A. B. and John, R. M. 2019. Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section. Psychoneuroendocrinology 108, pp. 14-19. (10.1016/j.psyneuen.2019.05.029)
- Seifinejad, A. et al. 2019. Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proceedings of the National Academy of Sciences 116(34), pp. 17061-17070. (10.1073/pnas.1902148116)
- John, R. M. 2019. Prenatal adversity modulates the quality of maternal care via the exposed offspring. BioEssays 41(6), article number: 1900025. (10.1002/bies.201900025)
- Creeth, H. D. J., McNamara, G. I., Isles, A. R. and John, R. M. 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53, article number: 100732. (10.1016/j.yfrne.2018.12.003)
- Garay, S. M., Savory, K. A., Sumption, L., Penketh, R., Janssen, A. B. and John, R. M. 2019. The Grown in Wales Study: Examining dietary patterns, custom birthweight centiles and the risk of delivering a small-for-gestational age (SGA) infant. PLoS ONE 14(3), article number: e0213412. (10.1371/journal.pone.0213412)
- Tucci, V. et al. 2019. Genomic imprinting and physiological processes in mammals. Cell 176(5), pp. 952-965. (10.1016/j.cell.2019.01.043)
- Isles, A. R. and John, R. M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25, pp. 31-35. (10.1016/j.cobeha.2018.06.008)
2018
- Garcia-Martin, I., Penketh, R., Janssen, A. B., Jones, R. E., Grimstead, J., Baird, D. and John, R. 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13(12), article number: : e0208533. (10.1371/journal.pone.0208533)
- Millership, S. J. et al. 2018. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Molecular Metabolism 18, pp. 97-106. (10.1016/j.molmet.2018.09.001)
- Tunster, S. J., Van de Pette, M., Creeth, H. D. J., Lefebvre, L. and John, R. M. 2018. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Disease Models and Mechanisms 11, article number: dmm035832. (10.1242/dmm.035832)
- John, R. and Rougelle, C. 2018. Developmental epigenetics: phenotype and the flexible epigenome. Frontiers in Cell and Developmental Biology 6, article number: 130. (10.3389/fcell.2018.00130)
- Tunster, S. J., Boque Sastre, R., McNamara, G., Hunter, S. M., Creeth, H. D. J. and John, R. M. 2018. Peg3 deficiency results in sexually dimorphic losses and gains in the normal repertoire of placental hormones. Frontiers in Cell and Developmental Biology 6, article number: 123. (10.3389/fcell.2018.00123)
- Van de Pette, M., Tunster, S. J. and John, R. M. 2018. Loss of imprinting of Cdkn1c protects against age and diet-induced obesity. International Journal of Molecular Sciences 19(9), article number: 2734. (10.3390/ijms19092734)
- Janssen, A. et al. 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4(5), pp. 354-360. (10.1192/bjo.2018.48)
- Millership, S. J. et al. 2018. Neuronatin regulates pancreatic β cell insulin content and secretion. Journal of Clinical Investigation 128(8), pp. 3369-3381. (10.1172/JCI120115)
- Creeth, H. D. J. et al. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16(7), article number: e2006599. (10.1371/journal.pbio.2006599)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17(2), pp. 149-157. (10.1111/gbb.12422)
- McNamara, G., John, R. and Isles, A. 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12, article number: 28. (10.3389/fnbeh.2018.00028)
- McNamara, G. I., Creeth, H. D. J., Harrison, D. J., Tansey, K. E., Andrews, R. M., Isles, A. R. and John, R. M. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27(3), pp. 440-450. (10.1093/hmg/ddx412)
2017
- Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
- John, R. M. 2017. Imprinted genes and the regulation of placental endocrine function: pregnancy and beyond. Placenta 56, pp. 86-90. (10.1016/j.placenta.2017.01.099)
- Nomura, Y. et al. 2017. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of Gynecology and Obstetrics 295(6), pp. 1319-1329. (10.1007/s00404-017-4347-3)
- Van de Pette, M. et al. 2017. Visualizing changes in Cdkn1c expression links early-Life adversity to imprint mis-regulation in adults. Cell Reports 18(5), pp. 1090-1099. (10.1016/j.celrep.2017.01.010)
2016
- McNamara, G. I., Davis, B. A., Dwyer, D. M., John, R. M. and Isles, A. R. 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25(24), pp. 5407-5417. (10.1093/hmg/ddw357)
- Janssen, A. et al. 2016. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 46(14), pp. 2999-3011. (10.1017/S0033291716001598)
- Tunster, S. J., McNamara, G., Creeth, H. and John, R. M. 2016. Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Developmental Biology 418(1), pp. 55-65. (10.1016/j.ydbio.2016.08.014)
- Janssen, A. B., Kertes, D. A., McNamara, G., Braithwaite, E. C., Creeth, H., Glover, V. I. and John, R. M. 2016. A role for the placenta in programming maternal mood and childhood behavioural disorders. Journal of Neuroendocrinology 28(8) (10.1111/jne.12373)
- Van De Pette, M. et al. 2016. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genetics 12(3), article number: e1005916. (10.1371/journal.pgen.1005916)
- Janssen, A. B., Tunster, S. J., Heazell, A. E. P. and John, R. M. 2016. Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements. BMC Medical Genetics 17(1), article number: 17. (10.1186/s12881-016-0279-1)
- Tunster, S. J., Creeth, H. and John, R. M. 2016. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Developmental Biology 409(1), pp. 251-260. (10.1016/j.ydbio.2015.10.015)
2015
- Kitamura, A. et al. 2015. Epigenetic alterations in sperm associated with male infertility. Congenital Anomalies 55(3), pp. 133-144. (10.1111/cga.12113)
- Janssen, A. B. et al. 2015. Placental expression of imprinted genes varies with sampling site and mode of delivery. Placenta 36(8), pp. 790-795. (10.1016/j.placenta.2015.06.011)
2014
- Tunster, S. J., Van De Pette, M. and John, R. M. 2014. Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice. Disease Models & Mechanisms 7(10), pp. 1185-1191. (10.1242/dmm.017079)
- Jensen, A. B., Tunster, S. J. and John, R. M. 2014. The significance of elevated placental PHLDA2 in human growth restricted pregnancies. Placenta 35(8), pp. 528-532. (10.1016/j.placenta.2014.04.018)
- Hiura, H. et al. 2014. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip [Correction]. Nucleic Acids Research 42(16), article number: 10869. (10.1093/nar/gku624)
2013
- Tunster, S. J., Jensen, A. B. and John, R. M. 2013. Imprinted genes in mouse placental development and the regulation of fetal energy stores. Reproduction 145(5), pp. R117-R137. (10.1530/REP-12-0511)
- John, R. M. 2013. Epigenetic regulation of placental endocrine lineages and complications of pregnancy. Biochemical Society Transactions 41(3), pp. 701-709. (10.1042/BST20130002)
2012
- Reed, K. R., Tunster, S. J., Young, M., Carrico, A. S., John, R. M. and Clarke, A. R. 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61(10), pp. 1435-1438. (10.1136/gutjnl-2011-300842)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2012. Impact of genetic background on placental glycogen storage in mice.. Placenta 33(2), pp. 124-127. (10.1016/j.placenta.2011.11.011)
- Ackerman, W. E. I. et al. 2012. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells.. Placenta 33(Suppl), pp. S15-S22. (10.1016/j.placenta.2011.11.022)
- Lewis, R. M. et al. 2012. Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone 50(1), pp. 337-342. (10.1016/j.bone.2011.11.003)
- Hiura, H. et al. 2012. Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27(8), pp. 2541-2548. (10.1093/humrep/des197)
- Clarke, A. J. et al. 2012. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care. Human Genomics 6, article number: 11. (10.1186/1479-7364-6-11)
- John, R. M. and Hemberger, M. 2012. A placenta for life. Reproductive BioMedicine Online 25(1), pp. 5-11. (10.1016/j.rbmo.2012.03.018)
2011
- John, R. M. and Lefebvre, L. 2011. Developmental regulation of somatic imprints.. Differentiation 81(5), pp. 270-280. (10.1016/j.diff.2011.01.007)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2011. BACs as tools for the study of genomic imprinting. Journal of Biomedicine and Biotechnology 2011, article number: 283013. (10.1155/2011/283013)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2011. Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Disease Models & Mechanisms 4(6), pp. 814-821. (10.1242/dmm.007328)
2010
- Wood, M. D., Hiura, H., Tunster, S. J., Arima, T., Shin, J., Higgins, M. and John, R. M. 2010. Autonomous silencing of the imprinted Cdkn1c gene in stem cells. Epigenetics 5(3), pp. 214-221. (10.4161/epi.5.3.11275)
- John, R. M. 2010. Engineering mouse models to investigate the function of imprinting. Briefings in Functional Genomics 9(4), pp. 294-303. (10.1093/bfgp/elq010)
- Hiura, H. et al. 2010. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Research 38(15), pp. 4929-4945. (10.1093/nar/gkq200)
- Tunster, S. J., Tycko, B. and John, R. M. 2010. The imprinted Phlda2 gene regulates extraembryonic energy stores. Molecular and Cellular Biology 30(1), pp. 295-306. (10.1128/MCB.00662-09)
2009
- Kobayashi, H. et al. 2009. DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17(1582-1) (10.1038/ejhg.2009.68)
2008
- Sowpati, D. et al. 2008. An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mechanisms of Development 125(11/12), pp. 963-973. (10.1016/j.mod.2008.08.002 |)
2007
- Andrews, S. C., Wood, M. D., Tunster, S. J., Barton, S. C., Surani, M. A. and John, R. M. 2007. Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Developmental Biology 7, article number: 53. (10.1186/1471-213x-7-53)
2006
- Azuara, V. et al. 2006. Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8(5), pp. 532-538. (10.1038/ncb1403)
- Arima, T. et al. 2006. The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Genomics 88(5), pp. 650-658. (10.1016/j.ygeno.2006.07.005)
2005
- Zvetkova, I. et al. 2005. Global hypomethylation of the genome in XX embryonic stem cells. Nature Genetics 37(11), pp. 1274-1279. (10.1038/ng1663)
2004
- Baxter, J. et al. 2004. Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal 23(22), pp. 4462-4472. (10.1038/sj.emboj.7600414)
- Salas, M. et al. 2004. Placental growth retardation due to loss of imprinting of Phlda2. Mechanisms of Development 121(10), pp. 1199-1210. (10.1016/j.mod.2004.05.017)
2002
- John, R. M., Ainscough, J. and Barton, S. C. 2002. A transgenic approach to studying imprinted genes: modified BACs and PACs. In: Ward, A. ed. Genomic Imprinting., Vol. 181. Methods in Molecular Biology Humana Press, pp. 67-81., (10.1385/1-59259-211-2:67)
- Ainscough, J., John, R. M. and Barton, S. C. 2002. Production of YAC transgenic mice by pronuclear injection. In: Ward, A. ed. Genomic Imprinting., Vol. 181. Methods in Molecular Biology Humana Press, pp. 55-65., (10.1385/1-59259-211-2:55)
2001
- John, R. M., Ainscough, J., Aparicio, S. and Surani, M. 2001. Imprinted Expression of Neuronatin from Modified BAC Transgenes Reveals Regulation by Distinct and Distant Enhancers. Developmental Biology 236(2), pp. 387-399. (10.1006/dbio.2001.0327)
- John, R. M., Ainscough, J., Barton, S. C. and Surani, M. A. 2001. Distant cis-elements regulate imprinted expression of the mouse p57Kip2 (Cdkn1c) gene: Implications for the human disorder, Beckwith–Wiedemann syndrome. Human Molecular Genetics Vol.10(15), pp. 1601-1609. (10.1093/hmg/10.15.1601)
2000
- Ainscough, J., John, R. M., Barton, S. and Surani, M. A. 2000. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene. Development 127(18), pp. 3923-3930.
- John, R. M. 2000. Genomic imprinting, mammalian evolution, and the mystery of egg-laying mammals. Cell 101(6), pp. 585-588.
Adrannau llyfrau
- John, R. M. 2024. The placenta as a neuroendocrine organ. In: Brunton, P. J. and Grattan, D. R. eds. Neuroendocrine Regulation of Mammalian Pregnancy and Lactation. Springer, pp. 21-63., (10.1007/978-3-031-51138-7_2)
- John, R. M., Lefebvre, L. and Surani, M. A. 2022. Genomic imprinting: a paradigm for epigenetics of human diseases. In: Michels, K. B. ed. Epigenetic Epidemiology (2nd Edition). Springer, Cham, pp. 171-212., (10.1007/978-3-030-94475-9_8)
- John, R. M., Ainscough, J. and Barton, S. C. 2002. A transgenic approach to studying imprinted genes: modified BACs and PACs. In: Ward, A. ed. Genomic Imprinting., Vol. 181. Methods in Molecular Biology Humana Press, pp. 67-81., (10.1385/1-59259-211-2:67)
- Ainscough, J., John, R. M. and Barton, S. C. 2002. Production of YAC transgenic mice by pronuclear injection. In: Ward, A. ed. Genomic Imprinting., Vol. 181. Methods in Molecular Biology Humana Press, pp. 55-65., (10.1385/1-59259-211-2:55)
Erthyglau
- Prodani, C. et al. 2024. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific Reports 14(1), article number: 8528. (10.1038/s41598-024-59083-7)
- Tyson, H. R., Harrison, D. J., Higgs, M. J., Isles, A. R. and John, R. M. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18, article number: 1374781. (10.3389/fnins.2024.1374781)
- John, R., Higgs, M. J. and Isles, A. R. 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 (10.1038/s41576-023-00644-3)
- Higgs, M., Webberley, A., Allan, A., Talat, M., John, R. and Isles, A. 2023. The parenting hub of the hypothalamus is a focus of imprinted gene action. PLoS Genetics 19(10), article number: e1010961. (10.1371/journal.pgen.1010961)
- Burgess, R. et al. 2023. A quantitative evaluation of thin slice sampling for parent-infant interactions. Journal of Nonverbal Behavior 47, pp. 117-210. (10.1007/s10919-022-00420-7)
- Higgs, M., Hill, M., John, R. and Isles, A. 2022. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution. BMC Genomics 23, article number: 754. (10.1186/s12864-022-08986-8)
- Garay, S. M., Sumption, L. and John, R. 2022. Prenatal health behaviours as predictors of human placental lactogen levels. Frontiers in Endocrinology 13, article number: 946539. (10.3389/fendo.2022.946539)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150, article number: 47-53. (10.1016/j.jpsychires.2022.03.009)
- Van de Pette, M. et al. 2022. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nature Communications 13(1), article number: 2464. (10.1038/s41467-022-30022-2)
- John, R. M. 2022. In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring. Experimental Physiology 107(5), pp. 398-404. (10.1113/EP089916)
- Savory, N. A., Hannigan, B., John, R. M., Sanders, J. and Garay, S. M. 2021. Prevalence and predictors of poor mental health among pregnant women in Wales using a cross-sectional survey. Midwifery 103, article number: 103103. (10.1016/j.midw.2021.103103)
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30(19), pp. 1863-1880., article number: ddab154. (10.1093/hmg/ddab154)
- Garcia Martin, I., Penketh, R. J. A., Garay, S. M., Jones, R. E., Grimstead, J. W., Baird, D. M. and John, R. M. 2021. Symptoms of prenatal depression associated with shorter telomeres in female placenta. International Journal of Molecular Sciences 22(14), article number: 7458. (10.3390/ijms22147458)
- Dingsdale, H. et al. 2021. The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor. Translational Psychiatry 11(1), article number: 62. (10.1038/s41398-020-01176-8)
- Garay, S., Sumption, L., Pearson, R. and John, R. 2021. Risk factors for excessive gestational weight gain in a UK population: A biopsychosocial model approach. BMC Pregnancy and Childbirth 21, article number: 43. (10.1186/s12884-020-03519-1)
- Creeth, H. D. J. and John, R. M. 2020. The placental programming hypothesis: placental endocrine insufficiency and the co-occurrence of low birth weight and maternal mood disorders. Placenta 98, pp. 52-59. (10.1016/j.placenta.2020.03.011)
- Sumption, L. A., Garay, S. M. and John, R. M. 2020. Low serum placental lactogen at term is associated with postnatal symptoms of depression and anxiety in women delivering female infants. Psychoneuroendocrinology 116, article number: 104655. (10.1016/j.psyneuen.2020.104655)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14, article number: 313. (10.3389/fnins.2020.00313)
- Savory, K. et al. 2020. Prenatal symptoms of anxiety and depression associated with sex differences in both maternal perceptions of one year old infant temperament and researcher observed infant characteristics. Journal of Affective Disorders 264, pp. 383-392. (10.1016/j.jad.2019.11.057)
- Garay, S. M., Savory, K. A., Sumption, L. A., Penketh, R. J., Jones, I. R., Janssen, A. B. and John, R. M. 2019. Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section. Psychoneuroendocrinology 108, pp. 14-19. (10.1016/j.psyneuen.2019.05.029)
- Seifinejad, A. et al. 2019. Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proceedings of the National Academy of Sciences 116(34), pp. 17061-17070. (10.1073/pnas.1902148116)
- John, R. M. 2019. Prenatal adversity modulates the quality of maternal care via the exposed offspring. BioEssays 41(6), article number: 1900025. (10.1002/bies.201900025)
- Creeth, H. D. J., McNamara, G. I., Isles, A. R. and John, R. M. 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53, article number: 100732. (10.1016/j.yfrne.2018.12.003)
- Garay, S. M., Savory, K. A., Sumption, L., Penketh, R., Janssen, A. B. and John, R. M. 2019. The Grown in Wales Study: Examining dietary patterns, custom birthweight centiles and the risk of delivering a small-for-gestational age (SGA) infant. PLoS ONE 14(3), article number: e0213412. (10.1371/journal.pone.0213412)
- Tucci, V. et al. 2019. Genomic imprinting and physiological processes in mammals. Cell 176(5), pp. 952-965. (10.1016/j.cell.2019.01.043)
- Isles, A. R. and John, R. M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25, pp. 31-35. (10.1016/j.cobeha.2018.06.008)
- Garcia-Martin, I., Penketh, R., Janssen, A. B., Jones, R. E., Grimstead, J., Baird, D. and John, R. 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13(12), article number: : e0208533. (10.1371/journal.pone.0208533)
- Millership, S. J. et al. 2018. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Molecular Metabolism 18, pp. 97-106. (10.1016/j.molmet.2018.09.001)
- Tunster, S. J., Van de Pette, M., Creeth, H. D. J., Lefebvre, L. and John, R. M. 2018. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Disease Models and Mechanisms 11, article number: dmm035832. (10.1242/dmm.035832)
- John, R. and Rougelle, C. 2018. Developmental epigenetics: phenotype and the flexible epigenome. Frontiers in Cell and Developmental Biology 6, article number: 130. (10.3389/fcell.2018.00130)
- Tunster, S. J., Boque Sastre, R., McNamara, G., Hunter, S. M., Creeth, H. D. J. and John, R. M. 2018. Peg3 deficiency results in sexually dimorphic losses and gains in the normal repertoire of placental hormones. Frontiers in Cell and Developmental Biology 6, article number: 123. (10.3389/fcell.2018.00123)
- Van de Pette, M., Tunster, S. J. and John, R. M. 2018. Loss of imprinting of Cdkn1c protects against age and diet-induced obesity. International Journal of Molecular Sciences 19(9), article number: 2734. (10.3390/ijms19092734)
- Janssen, A. et al. 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4(5), pp. 354-360. (10.1192/bjo.2018.48)
- Millership, S. J. et al. 2018. Neuronatin regulates pancreatic β cell insulin content and secretion. Journal of Clinical Investigation 128(8), pp. 3369-3381. (10.1172/JCI120115)
- Creeth, H. D. J. et al. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16(7), article number: e2006599. (10.1371/journal.pbio.2006599)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17(2), pp. 149-157. (10.1111/gbb.12422)
- McNamara, G., John, R. and Isles, A. 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12, article number: 28. (10.3389/fnbeh.2018.00028)
- McNamara, G. I., Creeth, H. D. J., Harrison, D. J., Tansey, K. E., Andrews, R. M., Isles, A. R. and John, R. M. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27(3), pp. 440-450. (10.1093/hmg/ddx412)
- Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
- John, R. M. 2017. Imprinted genes and the regulation of placental endocrine function: pregnancy and beyond. Placenta 56, pp. 86-90. (10.1016/j.placenta.2017.01.099)
- Nomura, Y. et al. 2017. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of Gynecology and Obstetrics 295(6), pp. 1319-1329. (10.1007/s00404-017-4347-3)
- Van de Pette, M. et al. 2017. Visualizing changes in Cdkn1c expression links early-Life adversity to imprint mis-regulation in adults. Cell Reports 18(5), pp. 1090-1099. (10.1016/j.celrep.2017.01.010)
- McNamara, G. I., Davis, B. A., Dwyer, D. M., John, R. M. and Isles, A. R. 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25(24), pp. 5407-5417. (10.1093/hmg/ddw357)
- Janssen, A. et al. 2016. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 46(14), pp. 2999-3011. (10.1017/S0033291716001598)
- Tunster, S. J., McNamara, G., Creeth, H. and John, R. M. 2016. Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Developmental Biology 418(1), pp. 55-65. (10.1016/j.ydbio.2016.08.014)
- Janssen, A. B., Kertes, D. A., McNamara, G., Braithwaite, E. C., Creeth, H., Glover, V. I. and John, R. M. 2016. A role for the placenta in programming maternal mood and childhood behavioural disorders. Journal of Neuroendocrinology 28(8) (10.1111/jne.12373)
- Van De Pette, M. et al. 2016. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genetics 12(3), article number: e1005916. (10.1371/journal.pgen.1005916)
- Janssen, A. B., Tunster, S. J., Heazell, A. E. P. and John, R. M. 2016. Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements. BMC Medical Genetics 17(1), article number: 17. (10.1186/s12881-016-0279-1)
- Tunster, S. J., Creeth, H. and John, R. M. 2016. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Developmental Biology 409(1), pp. 251-260. (10.1016/j.ydbio.2015.10.015)
- Kitamura, A. et al. 2015. Epigenetic alterations in sperm associated with male infertility. Congenital Anomalies 55(3), pp. 133-144. (10.1111/cga.12113)
- Janssen, A. B. et al. 2015. Placental expression of imprinted genes varies with sampling site and mode of delivery. Placenta 36(8), pp. 790-795. (10.1016/j.placenta.2015.06.011)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2014. Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice. Disease Models & Mechanisms 7(10), pp. 1185-1191. (10.1242/dmm.017079)
- Jensen, A. B., Tunster, S. J. and John, R. M. 2014. The significance of elevated placental PHLDA2 in human growth restricted pregnancies. Placenta 35(8), pp. 528-532. (10.1016/j.placenta.2014.04.018)
- Hiura, H. et al. 2014. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip [Correction]. Nucleic Acids Research 42(16), article number: 10869. (10.1093/nar/gku624)
- Tunster, S. J., Jensen, A. B. and John, R. M. 2013. Imprinted genes in mouse placental development and the regulation of fetal energy stores. Reproduction 145(5), pp. R117-R137. (10.1530/REP-12-0511)
- John, R. M. 2013. Epigenetic regulation of placental endocrine lineages and complications of pregnancy. Biochemical Society Transactions 41(3), pp. 701-709. (10.1042/BST20130002)
- Reed, K. R., Tunster, S. J., Young, M., Carrico, A. S., John, R. M. and Clarke, A. R. 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61(10), pp. 1435-1438. (10.1136/gutjnl-2011-300842)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2012. Impact of genetic background on placental glycogen storage in mice.. Placenta 33(2), pp. 124-127. (10.1016/j.placenta.2011.11.011)
- Ackerman, W. E. I. et al. 2012. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells.. Placenta 33(Suppl), pp. S15-S22. (10.1016/j.placenta.2011.11.022)
- Lewis, R. M. et al. 2012. Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone 50(1), pp. 337-342. (10.1016/j.bone.2011.11.003)
- Hiura, H. et al. 2012. Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27(8), pp. 2541-2548. (10.1093/humrep/des197)
- Clarke, A. J. et al. 2012. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care. Human Genomics 6, article number: 11. (10.1186/1479-7364-6-11)
- John, R. M. and Hemberger, M. 2012. A placenta for life. Reproductive BioMedicine Online 25(1), pp. 5-11. (10.1016/j.rbmo.2012.03.018)
- John, R. M. and Lefebvre, L. 2011. Developmental regulation of somatic imprints.. Differentiation 81(5), pp. 270-280. (10.1016/j.diff.2011.01.007)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2011. BACs as tools for the study of genomic imprinting. Journal of Biomedicine and Biotechnology 2011, article number: 283013. (10.1155/2011/283013)
- Tunster, S. J., Van De Pette, M. and John, R. M. 2011. Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Disease Models & Mechanisms 4(6), pp. 814-821. (10.1242/dmm.007328)
- Wood, M. D., Hiura, H., Tunster, S. J., Arima, T., Shin, J., Higgins, M. and John, R. M. 2010. Autonomous silencing of the imprinted Cdkn1c gene in stem cells. Epigenetics 5(3), pp. 214-221. (10.4161/epi.5.3.11275)
- John, R. M. 2010. Engineering mouse models to investigate the function of imprinting. Briefings in Functional Genomics 9(4), pp. 294-303. (10.1093/bfgp/elq010)
- Hiura, H. et al. 2010. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Research 38(15), pp. 4929-4945. (10.1093/nar/gkq200)
- Tunster, S. J., Tycko, B. and John, R. M. 2010. The imprinted Phlda2 gene regulates extraembryonic energy stores. Molecular and Cellular Biology 30(1), pp. 295-306. (10.1128/MCB.00662-09)
- Kobayashi, H. et al. 2009. DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17(1582-1) (10.1038/ejhg.2009.68)
- Sowpati, D. et al. 2008. An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mechanisms of Development 125(11/12), pp. 963-973. (10.1016/j.mod.2008.08.002 |)
- Andrews, S. C., Wood, M. D., Tunster, S. J., Barton, S. C., Surani, M. A. and John, R. M. 2007. Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Developmental Biology 7, article number: 53. (10.1186/1471-213x-7-53)
- Azuara, V. et al. 2006. Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8(5), pp. 532-538. (10.1038/ncb1403)
- Arima, T. et al. 2006. The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Genomics 88(5), pp. 650-658. (10.1016/j.ygeno.2006.07.005)
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- Baxter, J. et al. 2004. Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal 23(22), pp. 4462-4472. (10.1038/sj.emboj.7600414)
- Salas, M. et al. 2004. Placental growth retardation due to loss of imprinting of Phlda2. Mechanisms of Development 121(10), pp. 1199-1210. (10.1016/j.mod.2004.05.017)
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Ymchwil
Crynodeb
Prif ddiddordeb fy labordy yw deall sut mae marciau epigenetig yn cyfeirio datblygiad mamalaidd gyda ffocws penodol arno mewn prosesau utero, a sut y gall datguddiad yn ystod ffenestri difrifol sensitif mewn datblygiad newid canlyniadau i'r fam a'r plentyn.
Cysylltau
Cynhadledd Geneteg Cyhoeddus a Genomeg Rhagfyr 2024
"Pethau annisgwyl efallai nad ydych chi'n eu gwybod am y brycheuyn"
https://www.youtube.com/watch?v=1H6bR2kQ9RE/
2) Astudio wedi tyfu yng Nghymru
https://www.cardiff.ac.uk/biosciences/research/projects/grown-in-wales
3) Podlediad Cymdeithas Geneteg Oct 7th 2021
https://geneticsunzipped.com/blog/2021/10/7/science-genetics-placenta-mother-baby
Genomig Argraffu
System epigenetig yw mewnargraffu genomig, a gychwynnwyd gyntaf yn y llinell germau, sy'n cyfeirio mynegiant alel-benodol set fach o enynnau pwysig datblygiadol (Ffigur 1). Mae genynnau wedi'u hargraffu yn gweithredu o fewn myrdd o rwydweithiau i reoleiddio twf ffetws, datblygiad brychol, metaboledd ac ymddygiad. Adroddwyd am fynegiant aberrant o enynnau wedi'u hargraffu mewn perthynas â phwysau geni isel, camweithrediad brychol, clefydau metabolaidd a seiciatrig. Nod ein hymchwil yw deall ymhellach swyddogaeth sy'n gysylltiedig â dosages genynnau mewnargraffedig mewn datblygiad a chlefydau. Rydym hefyd yn ymchwilio i ffactorau a ffyrdd o fyw a allai ddylanwadu ar fynegiant genynnau argraffedig yn gynnar mewn bywyd gan arwain at gymhlethdodau beichiogrwydd, anhwylderau hwyliau a chanlyniadau ymddygiad gwaeth i blant yn y tymor byr ac ar draws cwrs bywyd.
Y brych
Rydym wedi dangos bod rhai genynnau sydd wedi'u hargraffu yn rheoleiddio maint adran endocrin y brych ac o ganlyniad yn modiwleiddio cynhyrchu hormonau brychol (Ffigur 2). Yn ystod beichiogrwydd mae hormonau brychol yn gorlifo'r cylchrediad mamol i gymell y newidiadau ffisiolegol sydd eu hangen ar gyfer beichiogrwydd llwyddiannus. Mae hormonau plasental yn sicrhau argaeledd maetholion i sicrhau twf ffetws priodol. Mae hormonau plas hefyd yn cysidro'r ymennydd mamol wrth baratoi ar gyfer mamoli'r baban newydd-anedig. Wedi'i ariannu gan BBSRC, rydym yn defnyddio modelau arbrofol unigryw yn seiliedig ar fynegiant genynnau sydd wedi'u hargraffu'n enetig a addaswyd yn enetig i ddangos yn arbrofol bod genynnau argraffedig yn dylanwadu ar dwf ffetws a rhoi gofal mamol trwy reoleiddio llinachau endocrin brychol (Ffigur 3).
Rhaglennu amgylcheddol
Mae genynnau sydd wedi'u hargraffu yn cael eu rheoleiddio gan nodau epigenetig sy'n gallu ymateb i ffactorau amgylcheddol. Yn ogystal ag archwilio canlyniadau mynegiant genynnau argraffedig Aberrant, a ariennir gan BBSRC, rydym yn ymchwilio i weld a all dietau neu gyflyrau penodol ar gyfer mamau ddylanwadu ar fynegiant genynnau yn y brych sy'n achosi camweithrediad endocrin brychol (Ffigur 4) ac yn y ffetws sy'n dylanwadu'n uniongyrchol ar ddatblygiad, a gall y ddau ohonynt fod yn gysylltiedig â'r canlyniadau tlotaf i blant.
Iechyd gydol oes
Mae'n hysbys bod adfyd cyn-enedigol yn gysylltiedig â chanlyniadau tlotach i blant gan gynnwys anawsterau ymddygiad ac anhwylderau metabolaidd. Wedi'i ariannu gan BBSRC ac Ymddiriedolaeth Wellcome, rydym yn archwilio canlyniadau camweithrediad endocrin brychol ar ganlyniadau epil sy'n canolbwyntio ar ymddygiad epil (Ffigur 4).
Ymgysylltiad clinigol
Mae'r genynnau argraffedig yr ydym yn eu hastudio yn rheoleiddio datblygiad brychol, twf ffetws ac addasiadau mamol i feichiogrwydd trwy reoleiddio signalau brychol. Mae'r mynegiant aberrant o enynnau sydd wedi'u hargraffu yn gyffredin mewn nifer o anhwylderau dynol beichiogrwydd gan gynnwys pwysau geni isel, diabetes beichiogrwydd a preeclampsia. Mae ein gwaith diweddar yn awgrymu y gallai argraffu aberrant hefyd fod yn berthnasol i anhwylderau hwyliau mamau a raglennir gan gamweithrediad brychol. Wedi'i ariannu gan MRC, cychwynnwyd "The Grown in Wales" Study (Ffigur 5) i gasglu data a samplau biolegol gan gynnwys brych gan fenywod sy'n cyflwyno'n lleol yn Ysbyty Athrofaol Cymru i integreiddio'r wybodaeth a gafwyd o'n modelau arbrofol gydag astudiaethau ar samplau dynol. Rydym hefyd yn asesu datblygiad ac ymddygiad y plant o'r astudiaeth hon yn "The Grown in Wales Infant Study" a ariennir gan Sefydliad Waterloo. Bydd ein gwaith yn hyrwyddo'r dehongliad gorau posibl o ddata clinigol gyda nod tymor hwy o wella perfformiad diagnostig ac adnabod targedau therapiwtig posibl ar gyfer triniaeth.
Astudiaeth glinigol
"The Grown in Wales Study: Datblygu ac offeryn placentomic ar gyfer nodweddu beichiogrwydd annodweddiadol a rhagweld canlyniadau."
Rhif cyfeirnod REC 15/WA/0004; ID prosiect IRAS 166243; UKCRN ID 18894
Cymorth grant cyfredol
Grantiau gweithredol fel ymgeisydd arweiniol
- BBSRC (2021-24) genynnau wedi'u hargraffu fel prif reoleiddwyr hormonau brychol.
- BBSRC (2021-24) Trallod cyn-geni a throsglwyddiad rhwng cenedlaethau o roi gofal mamau annodweddiadol.
- TWF (2021-22) Archwilio a yw iselder yn ystod beichiogrwydd yn effeithio ar faeth omega-3/6 a throsglwyddo brych gan gynyddu'r risg o anhwylderau niwroddatblygiadol
Grantiau gweithredol fel cyd-ymgeisydd
- Ymddiriedolaeth Leverhulme (2021-24) Cyfraniad genynnau wedi'u hargraffu'n famol i ymddygiad rhieni.
- Sefydliad Ymchwil Prader-Willi (2020-21) Rôl y brych yn PWS: mapio mynegiant genynnau PWS
- Wellcome Trust Neuroscience DTG "Dull lefel system i nodi a dilysu genynnau sydd wedi'u hargraffu sy'n ymwneud â gofal rhieni" (2019-2022)
Cydweithredwyr allanol
Amanda Fisher (MRC London Institute of Medical Sciences, Coleg Imperial Llundain)
Takahiro Arima (Prifysgol Tokoyu, Japan)
Sefydliad cyfarfod
Cyfarfod Genes, Datblygu a Chlefydau Mamalaidd Blynyddol (a ariennir gan y Gymdeithas Geneteg)
(Cylchdroi rhwng Caerdydd, Caerfaddon, Bryste a Chaerwysg)
Bydd y cyfarfod hwn yn cael ei gynnal yn y Royal Society Llundain 18/11/22.
Staff cysylltiedig
Ekaterina Lysikova
Ryan Sixtus
Myfyrwyr ymchwil ôl-raddedig
Fel prif oruchwyliwr
Fel ail oruchwyliwr
Cindy Ikie (BIOSI PhD)
Addysgu
BI2332 Concepts of Disease: Epigenetics and Underlying Principles
BI3351 Contemporary Topics in Disease: Mouse models of imprinting
BI3001 Biosciences Final Year Project.
BIT002 MRes Research Techniques in Bioscience: Research seminar
Bywgraffiad
Mae Rosalind M John yn Athro Epigenetig Datblygiadol ac yn Gyfarwyddwr Ymchwil ar gyfer Ysgol y Biowyddorau ym Mhrifysgol Caerdydd. Derbyniodd ei PhD o Goleg Imperial, Prifysgol Llundain a hyfforddodd ym Mhrifysgol San Francisco California (UCSF) a Stanford, UDA, a Phrifysgol Caergrawnt. Mae ganddi hanes o >20 mlynedd yn epigeneteg datblygiad ffetws a brych gan ddefnyddio modelau anifeiliaid i astudio perthnasedd mewnbrintio genomig, a sut y gall ffactorau amgylcheddol gyfryngu canlyniadau ffenoteipig byr a gydol oes. Mae hi'n arbenigwr ar gynhyrchu llygod trawsgenig BAC (Phlda2, Cdkn1c ac Ascl2) a'r defnydd o fodelau colli swyddogaeth (Cdkn1c, Phlda2 a Peg3) i gael mewnwelediad ym mherthnasedd dos genynnau rheoledig. Mae ei grŵp wedi adrodd am ffenoteipiau sy'n effeithio ar dwf ffetws, datblygiad brychol, metaboledd, ymddygiad oedolion ac, yn fwyaf diweddar, ymddygiad mamau mewn ymateb i gamweithrediad endocrin brychol. Sefydlodd yr Athro John yr Astudiaeth Tyfu yng Nghymru a'r astudiaeth babanod Tyfu yng Nghymru i gyfieithu ei chanfyddiadau o fodelau arbrofol i bobl sy'n berthnasol i fabanod pwysau geni isel, anhwylderau hwyliau mamau ac anhwylderau niwroddatblygiadol mewn plant. Ariennir grŵp yr Athro John gan MRC, BBSRC, Wellcome, Sefydliad Waterloo a Llywodraeth Cymru. Mae'r Athro John yn gwasanaethu ar baneli MRC PSMB a UKRI FLF.
Aelodaethau proffesiynol
- The Genetics Society;
- British Society of Developmental Biology;
- International Society for Developmental Origins of Health and Disease;
- International Federation Placenta Associations;
- European Placenta Group;
- ESRC InteSTELA network;
- GeCIPs (Genomics England Clinical Interpretation Partnerships) subdomain Imprinting Disorders: Epigenomics, Aetiology and Stratification, or IDEAS);
Pwyllgorau ac adolygu
- Cymrodoriaethau Arweinydd y Dyfodol UKRI Rownd 7 2023 -
- Bwrdd cynghori gwyddonol Rhwydwaith Geneteg Llygoden Cenedlaethol MRC, Cadeirydd (2023- )
- Bwrdd Meddygaeth Poblogaeth a Systemau MRC 2021 -
- Panel Chwilio Gwobrau Biolegol y Gymdeithas Frenhinol 2021 -
- Cymdeithas Geneteg Aelod Pwyllgor Cyffredin 2021 -(Geneteg Celloedd a Datblygiadol)
- Prif Olygydd Arbenigol ar gyfer Frontiers in Cell and Developmental Biology: Epigenetics Datblygiadol (2019-2023)
- Panel Iechyd a Chyd-destun UKRI GCRF (2019-20)
- Panel Cyfweld Cymrodoriaethau Arweinwyr y Dyfodol UKRI Rownd 2 (2019)
- Panel Adolygu Arbenigol MRC ar gyfer Gwobrau Cydweithredol NRP y DU (2019).
- Panel Adolygu Arbenigol BBSRC A (2011-2017)
Meysydd goruchwyliaeth
I am interested in supervising PhD students in the areas of:
- genomic imprinting
- developmental epigenetics
- fetal programming
- mammalian placental biology
- maternal behaviour/maternal mood disorders
Ymgysylltu
ArrayContact Details
JohnRM@caerdydd.ac.uk
+44 29208 70145
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
+44 29208 70145
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Themâu ymchwil
Arbenigeddau
- Epigeneteg
- Bioleg datblygiadol ac atgenhedlu anifeiliaid
- Agweddau seicogymdeithasol ar enedigaeth ac iechyd meddwl amenedigol
- Ymddygiad Rhieni
- Endocrinoleg
