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Yr Athro Ros John
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Ros John
Cyfarwyddwr Ymchwil, Athro
Ysgol y Biowyddorau
Trosolwyg
Trosolwg o'r ymchwil
Rydym yn mynd i'r afael ag un o'r cwestiynau mwyaf heriol a sylfaenol bwysig ym maes iechyd pobl, sef sut i wneud y mwyaf o'r siawns o feichiogrwydd iach a llwyddiannus. Mae gofal sy'n gysylltiedig â beichiogrwydd yn costio tua £5.8 biliwn y flwyddyn i'r GIG, ond dim ond 2.4% o'r holl gyllid uniongyrchol nad yw'n gysylltiedig â hielwch yn cael ei wario ar ymchwil sy'n gysylltiedig â beichiogrwydd (adroddiad RAND, 2020). Mae hyn yn nodi ymchwil beichiogrwydd fel un o'r meysydd ymchwil mwyaf tanariannu yn y DU. Ond dyma lle mae iechyd dynol yn dechrau a lle gallwn wneud y newidiadau mwyaf effeithiol i wella iechyd nid yn unig y fam ond hefyd ar gyfer cenedlaethau'r dyfodol.
Mae fy ymchwil yn ultilises modelau arbrofol a data carfan ddynol (The Grown in Wales Study) i 1) nodi genynnau wedi'u rheoleiddio'n epigenetig sy'n ymateb i adfyd cynenedigol; 2) peiriannu dos wedi'i newid o enynnau wedi'u hargraffu i archwilio'r effaith ar ddatblygiad y brych a thwf y ffetws; a 3) archwilio canlyniadau annigonolrwydd hormonau placental ar ymddygiad mamau a phlant. Trwy nodi mecanyddol sylfaenol sy'n cysylltu adfyd â chanlyniadau, byddwn yn llywio datblygu a gweithredu strategaethau newydd i fynd i'r afael ag iechyd gwael.
Rolau
- Dirprwy Bennaeth: Ymchwil, Arloesi a Menter
- Prif Ymchwilydd: Astudiaeth Tyfu yng Nghymru
- Arweinydd Tîm Academaidd
Cyhoeddiad
2026
- Jones, R. et al. 2026. Investigating the contribution of the imprinted gene Asb4 to parental care. European Journal of Neuroscience 64 (5) e70655. (10.1111/ejn.70655)
- Chibnall, A. et al. 2026. Sex-specific consequences of loss-of-imprinting of the maternally expressed gene Pleckstrin Homology-Like Domain Family A Member 2 (Phlda2) on placental development and fetal growth. Biology of Sex Differences (10.1186/s13293-026-00972-z)
- Webberley, A. E. et al., 2026. Placental defects revealed by modelling PWS in mice. Disease Models & Mechanisms (10.1242/dmm.052833)
2024
- John, R. M. 2024. The placenta as a neuroendocrine organ. In: Brunton, P. J. and Grattan, D. R. eds. Neuroendocrine Regulation of Mammalian Pregnancy and Lactation. Springer. , pp.21-63. (10.1007/978-3-031-51138-7_2)
- Prodani, C. et al., 2024. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific Reports 14 (1) 8528. (10.1038/s41598-024-59083-7)
- Tyson, H. R. et al. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18 1374781. (10.3389/fnins.2024.1374781)
2023
- John, R. , Higgs, M. J. and Isles, A. R. 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 (10.1038/s41576-023-00644-3)
- Higgs, M. et al. 2023. The parenting hub of the hypothalamus is a focus of imprinted gene action. PLoS Genetics 19 (10) e1010961. (10.1371/journal.pgen.1010961)
- Burgess, R. et al., 2023. A quantitative evaluation of thin slice sampling for parent-infant interactions. Journal of Nonverbal Behavior 47 , pp.117-210. (10.1007/s10919-022-00420-7)
2022
- Higgs, M. et al. 2022. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution. BMC Genomics 23 754. (10.1186/s12864-022-08986-8)
- Garay, S. M. , Sumption, L. and John, R. 2022. Prenatal health behaviours as predictors of human placental lactogen levels. Frontiers in Endocrinology 13 946539. (10.3389/fendo.2022.946539)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150 47-53. (10.1016/j.jpsychires.2022.03.009)
- Van de Pette, M. et al., 2022. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nature Communications 13 (1) 2464. (10.1038/s41467-022-30022-2)
- John, R. M. 2022. In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring. Experimental Physiology 107 (5), pp.398-404. (10.1113/EP089916)
- John, R. M. , Lefebvre, L. and Surani, M. A. 2022. Genomic imprinting: a paradigm for epigenetics of human diseases. In: Michels, K. B. ed. Epigenetic Epidemiology (2nd Edition). Springer, Cham. , pp.171-212. (10.1007/978-3-030-94475-9_8)
2021
- Savory, N. A. et al. 2021. Prevalence and predictors of poor mental health among pregnant women in Wales using a cross-sectional survey. Midwifery 103 103103. (10.1016/j.midw.2021.103103)
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30 (19), pp.1863-1880. ddab154. (10.1093/hmg/ddab154)
- Garcia Martin, I. et al. 2021. Symptoms of prenatal depression associated with shorter telomeres in female placenta. International Journal of Molecular Sciences 22 (14) 7458. (10.3390/ijms22147458)
- Dingsdale, H. et al. 2021. The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor. Translational Psychiatry 11 (1) 62. (10.1038/s41398-020-01176-8)
- Garay, S. et al. 2021. Risk factors for excessive gestational weight gain in a UK population: A biopsychosocial model approach. BMC Pregnancy and Childbirth 21 43. (10.1186/s12884-020-03519-1)
2020
- Creeth, H. D. J. and John, R. M. 2020. The placental programming hypothesis: placental endocrine insufficiency and the co-occurrence of low birth weight and maternal mood disorders. Placenta 98 , pp.52-59. (10.1016/j.placenta.2020.03.011)
- Sumption, L. A. , Garay, S. M. and John, R. M. 2020. Low serum placental lactogen at term is associated with postnatal symptoms of depression and anxiety in women delivering female infants. Psychoneuroendocrinology 116 104655. (10.1016/j.psyneuen.2020.104655)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14 313. (10.3389/fnins.2020.00313)
- Savory, K. et al. 2020. Prenatal symptoms of anxiety and depression associated with sex differences in both maternal perceptions of one year old infant temperament and researcher observed infant characteristics. Journal of Affective Disorders 264 , pp.383-392. (10.1016/j.jad.2019.11.057)
2019
- Garay, S. M. et al. 2019. Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section. Psychoneuroendocrinology 108 , pp.14-19. (10.1016/j.psyneuen.2019.05.029)
- Seifinejad, A. et al., 2019. Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proceedings of the National Academy of Sciences 116 (34), pp.17061-17070. (10.1073/pnas.1902148116)
- John, R. M. 2019. Prenatal adversity modulates the quality of maternal care via the exposed offspring. BioEssays 41 (6) 1900025. (10.1002/bies.201900025)
- Creeth, H. D. J. et al., 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53 100732. (10.1016/j.yfrne.2018.12.003)
- Garay, S. M. et al. 2019. The Grown in Wales Study: Examining dietary patterns, custom birthweight centiles and the risk of delivering a small-for-gestational age (SGA) infant. PLoS ONE 14 (3) e0213412. (10.1371/journal.pone.0213412)
- Tucci, V. et al., 2019. Genomic imprinting and physiological processes in mammals. Cell 176 (5), pp.952-965. (10.1016/j.cell.2019.01.043)
- Isles, A. R. and John, R. M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25 , pp.31-35. (10.1016/j.cobeha.2018.06.008)
2018
- Garcia-Martin, I. et al., 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13 (12) : e0208533. (10.1371/journal.pone.0208533)
- Millership, S. J. et al. 2018. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Molecular Metabolism 18 , pp.97-106. (10.1016/j.molmet.2018.09.001)
- Tunster, S. J. et al. 2018. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Disease Models and Mechanisms 11 dmm035832. (10.1242/dmm.035832)
- John, R. and Rougelle, C. 2018. Developmental epigenetics: phenotype and the flexible epigenome. Frontiers in Cell and Developmental Biology 6 130. (10.3389/fcell.2018.00130)
- Tunster, S. J. et al. 2018. Peg3 deficiency results in sexually dimorphic losses and gains in the normal repertoire of placental hormones. Frontiers in Cell and Developmental Biology 6 123. (10.3389/fcell.2018.00123)
- Van de Pette, M. , Tunster, S. J. and John, R. M. 2018. Loss of imprinting of Cdkn1c protects against age and diet-induced obesity. International Journal of Molecular Sciences 19 (9) 2734. (10.3390/ijms19092734)
- Janssen, A. et al., 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4 (5), pp.354-360. (10.1192/bjo.2018.48)
- Millership, S. J. et al., 2018. Neuronatin regulates pancreatic β cell insulin content and secretion. Journal of Clinical Investigation 128 (8), pp.3369-3381. (10.1172/JCI120115)
- Creeth, H. D. J. et al. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16 (7) e2006599. (10.1371/journal.pbio.2006599)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2), pp.149-157. (10.1111/gbb.12422)
- McNamara, G. , John, R. and Isles, A. 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12 28. (10.3389/fnbeh.2018.00028)
- McNamara, G. I. et al. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27 (3), pp.440-450. (10.1093/hmg/ddx412)
2017
- Garcia Martin, I. et al. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59 , pp.61-68. (10.1016/j.placenta.2017.09.007)
- Nomura, Y. et al., 2017. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of Gynecology and Obstetrics 295 (6), pp.1319-1329. (10.1007/s00404-017-4347-3)
- Van de Pette, M. et al., 2017. Visualizing changes in Cdkn1c expression links early-Life adversity to imprint mis-regulation in adults. Cell Reports 18 (5), pp.1090-1099. (10.1016/j.celrep.2017.01.010)
- John, R. M. 2017. Imprinted genes and the regulation of placental endocrine function: pregnancy and beyond. Placenta 56 , pp.86-90. (10.1016/j.placenta.2017.01.099)
2016
- McNamara, G. I. et al. 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25 (24), pp.5407-5417. (10.1093/hmg/ddw357)
- Tunster, S. J. et al. 2016. Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Developmental Biology 418 (1), pp.55-65. (10.1016/j.ydbio.2016.08.014)
- Janssen, A. B. et al. 2016. A role for the placenta in programming maternal mood and childhood behavioural disorders. Journal of Neuroendocrinology 28 (8)(10.1111/jne.12373)
- Van De Pette, M. et al., 2016. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genetics 12 (3) e1005916. (10.1371/journal.pgen.1005916)
- Janssen, A. B. et al., 2016. Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements. BMC Medical Genetics 17 (1) 17. (10.1186/s12881-016-0279-1)
- Tunster, S. J. , Creeth, H. and John, R. M. 2016. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Developmental Biology 409 (1), pp.251-260. (10.1016/j.ydbio.2015.10.015)
- Janssen, A. et al. 2016. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 46 (14), pp.2999-3011. (10.1017/S0033291716001598)
2015
- Janssen, A. B. et al. 2015. Placental expression of imprinted genes varies with sampling site and mode of delivery. Placenta 36 (8), pp.790-795. (10.1016/j.placenta.2015.06.011)
- Kitamura, A. et al., 2015. Epigenetic alterations in sperm associated with male infertility. Congenital Anomalies 55 (3), pp.133-144. (10.1111/cga.12113)
2014
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2014. Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice. Disease Models & Mechanisms 7 (10), pp.1185-1191. (10.1242/dmm.017079)
- Jensen, A. B. , Tunster, S. J. and John, R. M. 2014. The significance of elevated placental PHLDA2 in human growth restricted pregnancies. Placenta 35 (8), pp.528-532. (10.1016/j.placenta.2014.04.018)
- Hiura, H. et al., 2014. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip [Correction]. Nucleic Acids Research 42 (16) 10869. (10.1093/nar/gku624)
2013
- John, R. M. 2013. Epigenetic regulation of placental endocrine lineages and complications of pregnancy. Biochemical Society Transactions 41 (3), pp.701-709. (10.1042/BST20130002)
- Tunster, S. J. , Jensen, A. B. and John, R. M. 2013. Imprinted genes in mouse placental development and the regulation of fetal energy stores. Reproduction 145 (5), pp.R117-R137. (10.1530/REP-12-0511)
2012
- Reed, K. R. et al. 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61 (10), pp.1435-1438. (10.1136/gutjnl-2011-300842)
- Ackerman, W. E. I. et al., 2012. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells.. Placenta 33 (Suppl), pp.S15-S22. (10.1016/j.placenta.2011.11.022)
- Clarke, A. J. et al., 2012. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care. Human Genomics 6 11. (10.1186/1479-7364-6-11)
- Hiura, H. et al., 2012. Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27 (8), pp.2541-2548. (10.1093/humrep/des197)
- John, R. M. and Hemberger, M. 2012. A placenta for life. Reproductive BioMedicine Online 25 (1), pp.5-11. (10.1016/j.rbmo.2012.03.018)
- Lewis, R. M. et al., 2012. Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone 50 (1), pp.337-342. (10.1016/j.bone.2011.11.003)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2012. Impact of genetic background on placental glycogen storage in mice.. Placenta 33 (2), pp.124-127. (10.1016/j.placenta.2011.11.011)
2011
- John, R. M. and Lefebvre, L. 2011. Developmental regulation of somatic imprints.. Differentiation 81 (5), pp.270-280. (10.1016/j.diff.2011.01.007)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2011. BACs as tools for the study of genomic imprinting. Journal of Biomedicine and Biotechnology 2011 283013. (10.1155/2011/283013)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2011. Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Disease Models & Mechanisms 4 (6), pp.814-821. (10.1242/dmm.007328)
2010
- Hiura, H. et al., 2010. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Research 38 (15), pp.4929-4945. (10.1093/nar/gkq200)
- John, R. M. 2010. Engineering mouse models to investigate the function of imprinting. Briefings in Functional Genomics 9 (4), pp.294-303. (10.1093/bfgp/elq010)
- Tunster, S. J. , Tycko, B. and John, R. M. 2010. The imprinted Phlda2 gene regulates extraembryonic energy stores. Molecular and Cellular Biology 30 (1), pp.295-306. (10.1128/MCB.00662-09)
- Wood, M. D. et al., 2010. Autonomous silencing of the imprinted Cdkn1c gene in stem cells. Epigenetics 5 (3), pp.214-221. (10.4161/epi.5.3.11275)
2009
- Kobayashi, H. et al., 2009. DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17 (1582-1)(10.1038/ejhg.2009.68)
2008
- Sowpati, D. et al., 2008. An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mechanisms of Development 125 (11/12), pp.963-973. (10.1016/j.mod.2008.08.002 |)
2007
- Andrews, S. C. et al. 2007. Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Developmental Biology 7 53. (10.1186/1471-213x-7-53)
2006
- Arima, T. et al., 2006. The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Genomics 88 (5), pp.650-658. (10.1016/j.ygeno.2006.07.005)
- Azuara, V. et al., 2006. Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8 (5), pp.532-538. (10.1038/ncb1403)
2005
- Zvetkova, I. et al., 2005. Global hypomethylation of the genome in XX embryonic stem cells. Nature Genetics 37 (11), pp.1274-1279. (10.1038/ng1663)
2004
- Baxter, J. et al., 2004. Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal 23 (22), pp.4462-4472. (10.1038/sj.emboj.7600414)
- Salas, M. et al., 2004. Placental growth retardation due to loss of imprinting of Phlda2. Mechanisms of Development 121 (10), pp.1199-1210. (10.1016/j.mod.2004.05.017)
2002
- Ainscough, J. , John, R. M. and Barton, S. C. 2002. Production of YAC transgenic mice by pronuclear injection. In: Ward, A. ed. Genomic Imprinting. Vol. 181, Methods in Molecular Biology Humana Press. , pp.55-65. (10.1385/1-59259-211-2:55)
- John, R. M. , Ainscough, J. and Barton, S. C. 2002. A transgenic approach to studying imprinted genes: modified BACs and PACs. In: Ward, A. ed. Genomic Imprinting. Vol. 181, Methods in Molecular Biology Humana Press. , pp.67-81. (10.1385/1-59259-211-2:67)
2001
- John, R. M. et al. 2001. Imprinted Expression of Neuronatin from Modified BAC Transgenes Reveals Regulation by Distinct and Distant Enhancers. Developmental Biology 236 (2), pp.387-399. (10.1006/dbio.2001.0327)
- John, R. M. et al. 2001. Distant cis-elements regulate imprinted expression of the mouse p57Kip2 (Cdkn1c) gene: Implications for the human disorder, Beckwith–Wiedemann syndrome. Human Molecular Genetics Vol.10 (15), pp.1601-1609. (10.1093/hmg/10.15.1601)
2000
- Ainscough, J. et al., 2000. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene. Development 127 (18), pp.3923-3930.
- John, R. M. 2000. Genomic imprinting, mammalian evolution, and the mystery of egg-laying mammals. Cell 101 (6), pp.585-588.
Adrannau llyfrau
- John, R. M. 2024. The placenta as a neuroendocrine organ. In: Brunton, P. J. and Grattan, D. R. eds. Neuroendocrine Regulation of Mammalian Pregnancy and Lactation. Springer. , pp.21-63. (10.1007/978-3-031-51138-7_2)
- John, R. M. , Lefebvre, L. and Surani, M. A. 2022. Genomic imprinting: a paradigm for epigenetics of human diseases. In: Michels, K. B. ed. Epigenetic Epidemiology (2nd Edition). Springer, Cham. , pp.171-212. (10.1007/978-3-030-94475-9_8)
- Ainscough, J. , John, R. M. and Barton, S. C. 2002. Production of YAC transgenic mice by pronuclear injection. In: Ward, A. ed. Genomic Imprinting. Vol. 181, Methods in Molecular Biology Humana Press. , pp.55-65. (10.1385/1-59259-211-2:55)
- John, R. M. , Ainscough, J. and Barton, S. C. 2002. A transgenic approach to studying imprinted genes: modified BACs and PACs. In: Ward, A. ed. Genomic Imprinting. Vol. 181, Methods in Molecular Biology Humana Press. , pp.67-81. (10.1385/1-59259-211-2:67)
Erthyglau
- Jones, R. et al. 2026. Investigating the contribution of the imprinted gene Asb4 to parental care. European Journal of Neuroscience 64 (5) e70655. (10.1111/ejn.70655)
- Chibnall, A. et al. 2026. Sex-specific consequences of loss-of-imprinting of the maternally expressed gene Pleckstrin Homology-Like Domain Family A Member 2 (Phlda2) on placental development and fetal growth. Biology of Sex Differences (10.1186/s13293-026-00972-z)
- Webberley, A. E. et al., 2026. Placental defects revealed by modelling PWS in mice. Disease Models & Mechanisms (10.1242/dmm.052833)
- Prodani, C. et al., 2024. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific Reports 14 (1) 8528. (10.1038/s41598-024-59083-7)
- Tyson, H. R. et al. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18 1374781. (10.3389/fnins.2024.1374781)
- John, R. , Higgs, M. J. and Isles, A. R. 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 (10.1038/s41576-023-00644-3)
- Higgs, M. et al. 2023. The parenting hub of the hypothalamus is a focus of imprinted gene action. PLoS Genetics 19 (10) e1010961. (10.1371/journal.pgen.1010961)
- Burgess, R. et al., 2023. A quantitative evaluation of thin slice sampling for parent-infant interactions. Journal of Nonverbal Behavior 47 , pp.117-210. (10.1007/s10919-022-00420-7)
- Higgs, M. et al. 2022. Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution. BMC Genomics 23 754. (10.1186/s12864-022-08986-8)
- Garay, S. M. , Sumption, L. and John, R. 2022. Prenatal health behaviours as predictors of human placental lactogen levels. Frontiers in Endocrinology 13 946539. (10.3389/fendo.2022.946539)
- Dingsdale, H. et al. 2022. Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year. Journal of Psychiatric Research 150 47-53. (10.1016/j.jpsychires.2022.03.009)
- Van de Pette, M. et al., 2022. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nature Communications 13 (1) 2464. (10.1038/s41467-022-30022-2)
- John, R. M. 2022. In support of the placental programming hypothesis: Placental endocrine insufficiency programs atypical behaviour in mothers and their offspring. Experimental Physiology 107 (5), pp.398-404. (10.1113/EP089916)
- Savory, N. A. et al. 2021. Prevalence and predictors of poor mental health among pregnant women in Wales using a cross-sectional survey. Midwifery 103 103103. (10.1016/j.midw.2021.103103)
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30 (19), pp.1863-1880. ddab154. (10.1093/hmg/ddab154)
- Garcia Martin, I. et al. 2021. Symptoms of prenatal depression associated with shorter telomeres in female placenta. International Journal of Molecular Sciences 22 (14) 7458. (10.3390/ijms22147458)
- Dingsdale, H. et al. 2021. The placenta protects the fetal circulation from anxiety-driven elevations in maternal serum levels of brain-derived neurotrophic factor. Translational Psychiatry 11 (1) 62. (10.1038/s41398-020-01176-8)
- Garay, S. et al. 2021. Risk factors for excessive gestational weight gain in a UK population: A biopsychosocial model approach. BMC Pregnancy and Childbirth 21 43. (10.1186/s12884-020-03519-1)
- Creeth, H. D. J. and John, R. M. 2020. The placental programming hypothesis: placental endocrine insufficiency and the co-occurrence of low birth weight and maternal mood disorders. Placenta 98 , pp.52-59. (10.1016/j.placenta.2020.03.011)
- Sumption, L. A. , Garay, S. M. and John, R. M. 2020. Low serum placental lactogen at term is associated with postnatal symptoms of depression and anxiety in women delivering female infants. Psychoneuroendocrinology 116 104655. (10.1016/j.psyneuen.2020.104655)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14 313. (10.3389/fnins.2020.00313)
- Savory, K. et al. 2020. Prenatal symptoms of anxiety and depression associated with sex differences in both maternal perceptions of one year old infant temperament and researcher observed infant characteristics. Journal of Affective Disorders 264 , pp.383-392. (10.1016/j.jad.2019.11.057)
- Garay, S. M. et al. 2019. Seasonal variation in salivary cortisol but not symptoms of depression and trait anxiety in pregnant women undergoing an elective caesarean section. Psychoneuroendocrinology 108 , pp.14-19. (10.1016/j.psyneuen.2019.05.029)
- Seifinejad, A. et al., 2019. Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons. Proceedings of the National Academy of Sciences 116 (34), pp.17061-17070. (10.1073/pnas.1902148116)
- John, R. M. 2019. Prenatal adversity modulates the quality of maternal care via the exposed offspring. BioEssays 41 (6) 1900025. (10.1002/bies.201900025)
- Creeth, H. D. J. et al., 2019. Imprinted genes influencing the quality of maternal care. Frontiers in Neuroendocrinology 53 100732. (10.1016/j.yfrne.2018.12.003)
- Garay, S. M. et al. 2019. The Grown in Wales Study: Examining dietary patterns, custom birthweight centiles and the risk of delivering a small-for-gestational age (SGA) infant. PLoS ONE 14 (3) e0213412. (10.1371/journal.pone.0213412)
- Tucci, V. et al., 2019. Genomic imprinting and physiological processes in mammals. Cell 176 (5), pp.952-965. (10.1016/j.cell.2019.01.043)
- Isles, A. R. and John, R. M. 2019. Genomic imprinting and neurobehavioral programming by adverse early life environments: evidence from studying Cdkn1c. Current Opinion in Behavioral Sciences 25 , pp.31-35. (10.1016/j.cobeha.2018.06.008)
- Garcia-Martin, I. et al., 2018. Meformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes. PLoS ONE 13 (12) : e0208533. (10.1371/journal.pone.0208533)
- Millership, S. J. et al. 2018. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Molecular Metabolism 18 , pp.97-106. (10.1016/j.molmet.2018.09.001)
- Tunster, S. J. et al. 2018. Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome. Disease Models and Mechanisms 11 dmm035832. (10.1242/dmm.035832)
- John, R. and Rougelle, C. 2018. Developmental epigenetics: phenotype and the flexible epigenome. Frontiers in Cell and Developmental Biology 6 130. (10.3389/fcell.2018.00130)
- Tunster, S. J. et al. 2018. Peg3 deficiency results in sexually dimorphic losses and gains in the normal repertoire of placental hormones. Frontiers in Cell and Developmental Biology 6 123. (10.3389/fcell.2018.00123)
- Van de Pette, M. , Tunster, S. J. and John, R. M. 2018. Loss of imprinting of Cdkn1c protects against age and diet-induced obesity. International Journal of Molecular Sciences 19 (9) 2734. (10.3390/ijms19092734)
- Janssen, A. et al., 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4 (5), pp.354-360. (10.1192/bjo.2018.48)
- Millership, S. J. et al., 2018. Neuronatin regulates pancreatic β cell insulin content and secretion. Journal of Clinical Investigation 128 (8), pp.3369-3381. (10.1172/JCI120115)
- Creeth, H. D. J. et al. 2018. Maternal care boosted by paternal imprinting in mammals. PLoS Biology 16 (7) e2006599. (10.1371/journal.pbio.2006599)
- McNamara, G. I. et al. 2018. Dopaminergic and behavioral changes in a loss-of-imprinting model of Cdkn1c. Genes, Brain and Behavior 17 (2), pp.149-157. (10.1111/gbb.12422)
- McNamara, G. , John, R. and Isles, A. 2018. Territorial behaviour and social stability in the mouse require correct expression of imprinted Cdkn1c. Frontiers in Behavioral Neuroscience 12 28. (10.3389/fnbeh.2018.00028)
- McNamara, G. I. et al. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27 (3), pp.440-450. (10.1093/hmg/ddx412)
- Garcia Martin, I. et al. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59 , pp.61-68. (10.1016/j.placenta.2017.09.007)
- Nomura, Y. et al., 2017. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of Gynecology and Obstetrics 295 (6), pp.1319-1329. (10.1007/s00404-017-4347-3)
- Van de Pette, M. et al., 2017. Visualizing changes in Cdkn1c expression links early-Life adversity to imprint mis-regulation in adults. Cell Reports 18 (5), pp.1090-1099. (10.1016/j.celrep.2017.01.010)
- John, R. M. 2017. Imprinted genes and the regulation of placental endocrine function: pregnancy and beyond. Placenta 56 , pp.86-90. (10.1016/j.placenta.2017.01.099)
- McNamara, G. I. et al. 2016. Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome. Human Molecular Genetics 25 (24), pp.5407-5417. (10.1093/hmg/ddw357)
- Tunster, S. J. et al. 2016. Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta. Developmental Biology 418 (1), pp.55-65. (10.1016/j.ydbio.2016.08.014)
- Janssen, A. B. et al. 2016. A role for the placenta in programming maternal mood and childhood behavioural disorders. Journal of Neuroendocrinology 28 (8)(10.1111/jne.12373)
- Van De Pette, M. et al., 2016. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genetics 12 (3) e1005916. (10.1371/journal.pgen.1005916)
- Janssen, A. B. et al., 2016. Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements. BMC Medical Genetics 17 (1) 17. (10.1186/s12881-016-0279-1)
- Tunster, S. J. , Creeth, H. and John, R. M. 2016. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Developmental Biology 409 (1), pp.251-260. (10.1016/j.ydbio.2015.10.015)
- Janssen, A. et al. 2016. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3. Psychological Medicine 46 (14), pp.2999-3011. (10.1017/S0033291716001598)
- Janssen, A. B. et al. 2015. Placental expression of imprinted genes varies with sampling site and mode of delivery. Placenta 36 (8), pp.790-795. (10.1016/j.placenta.2015.06.011)
- Kitamura, A. et al., 2015. Epigenetic alterations in sperm associated with male infertility. Congenital Anomalies 55 (3), pp.133-144. (10.1111/cga.12113)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2014. Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice. Disease Models & Mechanisms 7 (10), pp.1185-1191. (10.1242/dmm.017079)
- Jensen, A. B. , Tunster, S. J. and John, R. M. 2014. The significance of elevated placental PHLDA2 in human growth restricted pregnancies. Placenta 35 (8), pp.528-532. (10.1016/j.placenta.2014.04.018)
- Hiura, H. et al., 2014. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip [Correction]. Nucleic Acids Research 42 (16) 10869. (10.1093/nar/gku624)
- John, R. M. 2013. Epigenetic regulation of placental endocrine lineages and complications of pregnancy. Biochemical Society Transactions 41 (3), pp.701-709. (10.1042/BST20130002)
- Tunster, S. J. , Jensen, A. B. and John, R. M. 2013. Imprinted genes in mouse placental development and the regulation of fetal energy stores. Reproduction 145 (5), pp.R117-R137. (10.1530/REP-12-0511)
- Reed, K. R. et al. 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61 (10), pp.1435-1438. (10.1136/gutjnl-2011-300842)
- Ackerman, W. E. I. et al., 2012. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells.. Placenta 33 (Suppl), pp.S15-S22. (10.1016/j.placenta.2011.11.022)
- Clarke, A. J. et al., 2012. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care. Human Genomics 6 11. (10.1186/1479-7364-6-11)
- Hiura, H. et al., 2012. Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Human Reproduction 27 (8), pp.2541-2548. (10.1093/humrep/des197)
- John, R. M. and Hemberger, M. 2012. A placenta for life. Reproductive BioMedicine Online 25 (1), pp.5-11. (10.1016/j.rbmo.2012.03.018)
- Lewis, R. M. et al., 2012. Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone 50 (1), pp.337-342. (10.1016/j.bone.2011.11.003)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2012. Impact of genetic background on placental glycogen storage in mice.. Placenta 33 (2), pp.124-127. (10.1016/j.placenta.2011.11.011)
- John, R. M. and Lefebvre, L. 2011. Developmental regulation of somatic imprints.. Differentiation 81 (5), pp.270-280. (10.1016/j.diff.2011.01.007)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2011. BACs as tools for the study of genomic imprinting. Journal of Biomedicine and Biotechnology 2011 283013. (10.1155/2011/283013)
- Tunster, S. J. , Van De Pette, M. and John, R. M. 2011. Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Disease Models & Mechanisms 4 (6), pp.814-821. (10.1242/dmm.007328)
- Hiura, H. et al., 2010. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Research 38 (15), pp.4929-4945. (10.1093/nar/gkq200)
- John, R. M. 2010. Engineering mouse models to investigate the function of imprinting. Briefings in Functional Genomics 9 (4), pp.294-303. (10.1093/bfgp/elq010)
- Tunster, S. J. , Tycko, B. and John, R. M. 2010. The imprinted Phlda2 gene regulates extraembryonic energy stores. Molecular and Cellular Biology 30 (1), pp.295-306. (10.1128/MCB.00662-09)
- Wood, M. D. et al., 2010. Autonomous silencing of the imprinted Cdkn1c gene in stem cells. Epigenetics 5 (3), pp.214-221. (10.4161/epi.5.3.11275)
- Kobayashi, H. et al., 2009. DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17 (1582-1)(10.1038/ejhg.2009.68)
- Sowpati, D. et al., 2008. An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mechanisms of Development 125 (11/12), pp.963-973. (10.1016/j.mod.2008.08.002 |)
- Andrews, S. C. et al. 2007. Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Developmental Biology 7 53. (10.1186/1471-213x-7-53)
- Arima, T. et al., 2006. The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. Genomics 88 (5), pp.650-658. (10.1016/j.ygeno.2006.07.005)
- Azuara, V. et al., 2006. Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8 (5), pp.532-538. (10.1038/ncb1403)
- Zvetkova, I. et al., 2005. Global hypomethylation of the genome in XX embryonic stem cells. Nature Genetics 37 (11), pp.1274-1279. (10.1038/ng1663)
- Baxter, J. et al., 2004. Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal 23 (22), pp.4462-4472. (10.1038/sj.emboj.7600414)
- Salas, M. et al., 2004. Placental growth retardation due to loss of imprinting of Phlda2. Mechanisms of Development 121 (10), pp.1199-1210. (10.1016/j.mod.2004.05.017)
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- Ainscough, J. et al., 2000. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene. Development 127 (18), pp.3923-3930.
- John, R. M. 2000. Genomic imprinting, mammalian evolution, and the mystery of egg-laying mammals. Cell 101 (6), pp.585-588.
Ymchwil
Crynodeb
Prif ddiddordeb fy labordy yw deall sut mae marciau epigenetig yn uniongyrchol datblygiad mamaliaid gyda ffocws penodol ar brosesau yn y groth, a sut y gall amlygiad yn ystod ffenestri critigol sensitif mewn datblygiad newid canlyniadau i'r fam a'r plentyn.
Dolenni
1) Cynhadledd Geneteg a Genomeg Gyhoeddus Rhagfyr 2024
"Pethau syndod nad ydych efallai yn gwybod am y placenta"
https://www.youtube.com/watch?v=1H6bR2kQ9RE/
2) Astudiaeth Tyfu yng Nghymru
https://www.cardiff.ac.uk/biosciences/research/projects/grown-in-wales
3) Podlediad Cymdeithas Geneteg Hydref 7fed 2021
https://geneticsunzipped.com/blog/2021/10/7/science-genetics-placenta-mother-baby
Argraffu Genomig
Mae argraffu genomig yn system epigenetig, a gychwynnwyd gyntaf yn y llinell germ, sy'n cyfarwyddo mynegiant allel-benodol set fach o enynnau datblygiadol pwysig (Ffigur 1). Mae genynnau wedi'u hargraffu yn gweithredu o fewn myrdd o rwydweithiau i reoleiddio twf y ffetws, datblygiad y brych, metaboledd ac ymddygiad. Adroddwyd am fynegiant aberrant genynnau wedi'u hargraffu mewn perthynas â phwysau genynnau wedi'u hargraffu yn y tymor byr ac ar draws y cwrs oes. Rydym hefyd yn ymchwilio i ffactorau a ffyrdd o fyw a allai ddylanwadu ar fynegiant genynnau wedi'u hargraffu yn gynnar mewn bywyd gan arwain at gymhlethdodau beichiogrwydd, anhwylderau hwyliau a chanlyniadau ymddygiadol gwael i blant yn y tymor byr ac ar draws cwrs bywyd.
Y brych
Rydym wedi dangos bod rhai genynnau wedi'u hargraffu yn rheoleiddio maint compartment endocrin y brych ac o ganlyniad yn modiwleiddio cynhyrchu hormonau placental (Ffigur 2). Yn ystod beichiogrwydd, mae hormonau placental yn gorlifo cylchrediad y fam i ysgogi'r newidiadau ffisiolegol sydd eu hangen ar gyfer beichiogrwydd llwyddiannus. Mae hormonau placental yn sicrhau argaeledd maetholion i sicrhau twf ffetws priodol. Mae hormonau placental hefyd yn paratoi ymennydd y fam wrth baratoi ar gyfer mamau'r baban newydd-anedig. Wedi'i ariannu gan BBSRC, rydym yn defnyddio modelau arbrofol unigryw yn seiliedig ar fynegiant genynnau wedi'u haddasu'n enetig i ddangos yn arbrofol bod genynnau wedi'u hargraffu yn dylanwadu ar dwf y ffetws a gofal mamol trwy reoleiddio llinellau endocrin brych (Ffigur 3).
Rhaglennu amgylcheddol
Mae genynnau wedi'u hargraffu yn cael eu rheoleiddio gan farciau epigenetig sy'n gallu ymateb i ffactorau amgylcheddol. Yn ogystal ag archwilio canlyniadau mynegiant genynnau aberrant, a ariennir gan BBSRC, rydym yn ymchwilio a all dietau neu gyflyrau mamol penodol ddylanwadu ar fynegiant genynnau yn y brych gan achosi camweithrediad endocrin placental (Ffigur 4) ac yn y ffetws sy'n dylanwadu'n uniongyrchol ar ddatblygiad, y gall y ddau ohonynt fod yn gysylltiedig â'r canlyniadau gwael i blant.
Iechyd gydol oes
Mae'n hysbys bod adfyd cynenedigol yn gysylltiedig â chanlyniadau gwael i blant, gan gynnwys anawsterau ymddygiadol ac anhwylderau metabolig. Wedi'i ariannu gan BBSRC ac Ymddiriedolaeth Wellcome, rydym yn archwilio canlyniadau camweithrediad endocrin placental ar ganlyniadau epil gan ganolbwyntio ar ymddygiad epil (Ffigur 4).
Ymgysylltu clinigol
Mae'r genynnau argraffedig yr ydym yn eu hastudio yn rheoleiddio datblygiad y brych, twf y ffetws ac addasiadau mamau i feichiogrwydd trwy reoleiddio signalau brych. Mae mynegiant aberrant genynnau wedi'u hargraffu yn gyffredin mewn nifer o anhwylderau dynol o feichiogrwydd gan gynnwys pwysau geni isel, diabetes beichiog a preeclampsia. Mae ein gwaith diweddar yn awgrymu y gall imprinting aberrant hefyd fod yn berthnasol i anhwylderau hwyliau mamau a raglennir gan gamweithrediad y brych. Wedi'i ariannu gan MRC, fe wnaethom gychwyn Astudiaeth "The Grown in Wales" (Ffigur 5) i gasglu data a samplau biolegol gan gynnwys brych gan fenywod sy'n esgor yn lleol yn Ysbyty Athrofaol Cymru i integreiddio'r wybodaeth a gafwyd o'n modelau arbrofol gydag astudiaethau ar samplau dynol. Rydym hefyd yn asesu datblygiad ac ymddygiad y plant o'r astudiaeth hon yn "The Grown in Wales Infant Study" a ariennir gan The Waterloo Foundation. Bydd ein gwaith yn hyrwyddo'r dehongliad gorau posibl o ddata clinigol gyda nod tymor hwy o wella perfformiad diagnostig a nodi targedau therapiwtig posibl ar gyfer triniaeth.
Astudiaeth glinigol
"Yr Astudiaeth Tyfu yng Nghymru: Offeryn datblygu a phrychnamig ar gyfer nodweddu beichiogrwydd annodweddiadol a rhagfynegi canlyniadau."
Rhif cyfeirnod REC 15/WA/0004; ID prosiect IRAS 166243; ID UKCRN 18894
Addysgu
BI2332 Concepts of Disease: Epigenetics and Underlying Principles
BI3351 Contemporary Topics in Disease: Mouse models of imprinting
BI3001 Biosciences Final Year Project.
BIT002 MRes Research Techniques in Bioscience: Research seminar
Bywgraffiad
Mae Rosalind M John yn Athro Epigeneteg Datblygiadol a Dirprwy Bennaeth Ysgol y Biowyddorau ym Mhrifysgol Caerdydd sy'n gyfrifol am Ymchwil, Arloesi a Menter. Derbyniodd ei PhD o Goleg Imperial, Prifysgol Llundain a hyfforddwyd ym Mhrifysgol San Francisco California (UCSF) a Stanford, UDA, a Phrifysgol Caergrawnt. Dros fwy na 25 mlynedd mae hi wedi sefydlu rhaglen ymchwil a gydnabyddir yn rhyngwladol sy'n astudio argraffu genomig a bioleg placental gan drawsnewid ein dealltwriaeth o sut mae signalau placental yn dylanwadu ar ymddygiad mamau, datblygiad epil ac outomes hirdymor gyda goblygiadau mawr i iechyd pobl. Mae ei gwaith wedi cael ei ariannu'n bennaf gan grantiau UKRI parhaus fel Prif Ymchwilydd am fwy na dau ddegawd, ac mae hi wedi cyhoeddi'n helaeth mewn cyfnodolion mawreddog o fewn ei disgyblaeth.
Fel Dirprwy Bennaeth: Ymchwil, Arloesi a Menter a Chyd-arweinydd CU ar gyfer Uned Asesu 5 ar gyfer REF2029 mae'n darparu arweinyddiaeth strategol ar gyfer ymchwil ar draws BIOSI gan chwarae rhan ganolog mewn paratoadau REF2029, datblygu diwylliant ymchwil, cymorth grantiau, hyrwyddiadau, cynllunio strategol a buddsoddiad mewn seilwaith.
Yn genedlaethol, mae hi wedi gwasanaethu ar baneli grant modd ymateb BBSRC a MRC, mentrau arbennig UKRI FLF ac UKRI ac adolygiadau strategol o sefydliadau a ariennir gan UKRI. Ar hyn o bryd mae'n aelod gwasanaethol o Goleg Arbenigwyr MRC ac yn Gadeirydd Bwrdd Cynghori Gwyddonol Rhwydwaith Geneteg Llygoden Cenedlaethol MRC. Ochr yn ochr â nifer o gyflwyniadau gwahoddedig a phrif nodiadau mewn cynadleddau cenedlaethol a rhyngwladol, mae'r rolau hyn yn darparu tystiolaeth o ddylanwad ar strategaeth a buddsoddiad ymchwil y DU a pharch cenedlaethol/rhyngwladol.
Aelodaethau proffesiynol
- The Genetics Society;
- British Society of Developmental Biology;
- International Society for Developmental Origins of Health and Disease;
- International Federation Placenta Associations;
- European Placenta Group;
- ESRC InteSTELA network;
- GeCIPs (Genomics England Clinical Interpretation Partnerships) subdomain Imprinting Disorders: Epigenomics, Aetiology and Stratification, or IDEAS);
Pwyllgorau ac adolygu
- Cymrodoriaethau Arweinydd y Dyfodol UKRI Rownd 7 2023 -
- Bwrdd cynghori gwyddonol Rhwydwaith Geneteg Llygoden Cenedlaethol MRC, Cadeirydd (2023- )
- Bwrdd Meddygaeth Poblogaeth a Systemau MRC 2021 -
- Panel Chwilio Gwobrau Biolegol y Gymdeithas Frenhinol 2021 -
- Cymdeithas Geneteg Aelod Pwyllgor Cyffredin 2021 -(Geneteg Celloedd a Datblygiadol)
- Prif Olygydd Arbenigol ar gyfer Frontiers in Cell and Developmental Biology: Epigenetics Datblygiadol (2019-2023)
- Panel Iechyd a Chyd-destun UKRI GCRF (2019-20)
- Panel Cyfweld Cymrodoriaethau Arweinwyr y Dyfodol UKRI Rownd 2 (2019)
- Panel Adolygu Arbenigol MRC ar gyfer Gwobrau Cydweithredol NRP y DU (2019).
- Panel Adolygu Arbenigol BBSRC A (2011-2017)
Meysydd goruchwyliaeth
I am interested in supervising PhD students in the areas of:
- genomic imprinting
- developmental epigenetics
- fetal programming
- mammalian placental biology
- maternal behaviour/maternal mood disorders
Goruchwyliaeth gyfredol
Ymgysylltu
ArrayNews articles
Contact Details
Themâu ymchwil
Arbenigeddau
- Epigeneteg
- Bioleg datblygiadol ac atgenhedlu anifeiliaid
- Agweddau seicogymdeithasol ar enedigaeth ac iechyd meddwl amenedigol
- Ymddygiad Rhieni
- Endocrinoleg
