Yr Athro Emma Kidd
(Mae hi'n)
PhD FBPhS
Athro Ffarmacoleg, Cyfarwyddwr DTP MRC MRC GW4 BioMed2
Ysgol Fferylliaeth a Gwyddorau Fferyllol
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Qualifications
- BSc in Pharmacology, University of Bath, 1987
- PhD in Neuropharmacology, University of Nottingham, 1990
Relevant websites
- Alzheimer's Society
- BRACE (Bristol Research into Alzheimer's and Care of the Elderly)
- Alzheimers Research UK
Cyhoeddiad
2024
- Andrews, R., Lacey, A., Bache, K. and Kidd, E. J. 2024. The role of menopausal symptoms on future health and longevity: A systematic scoping review of longitudinal evidence. Maturitas: An international journal of midlife health and beyond 190, article number: 108130. (10.1016/j.maturitas.2024.108130)
- Canonica, T., Kidd, E. J., Gibbins, D., Lana-Elola, E., Fisher, E. M. C., Tybulewicz, V. L. J. and Good, M. 2024. Dissecting the contribution of human chromosome 21 syntenic regions to recognition memory processes in adult and aged mouse models of Down syndrome. Frontiers in Behavioral Neuroscience 18, article number: 1428146. (10.3389/fnbeh.2024.1428146)
2023
- Alsaqati, M., Thomas, R. S. and Kidd, E. J. 2023. Upregulation of endocytic protein expression in the Alzheimer's disease male human brain. Aging Brain 4, article number: 100084. (10.1016/j.nbas.2023.100084)
2021
- Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)
2020
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Hamilton, D. A., Kidd, E. and Metzler-Baddeley, C. 2020. Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults. Neurobiology of Aging 94, pp. 298-310. (10.1016/j.neurobiolaging.2020.06.014)
- Evans, C. E. et al. 2020. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease. Acta Neuropathologica 139, pp. 485-502. (10.1007/s00401-019-02098-6)
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Kidd, E., Aggleton, J. and Metzler-Baddeley, C. 2020. APOE-e4-related differences in left thalamic microstructure in cognitively healthy adults. Scientific Reports 10, article number: 19787. (10.1038/s41598-020-75992-9)
2019
- Metzler-Baddeley, C. et al. 2019. Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure. NeuroImage 189, pp. 793-803. (10.1016/j.neuroimage.2019.02.007)
- Evans, C. E., Thomas, R. S., Freeman, T. J., Hvoslef-Eide, M., Good, M. A. and Kidd, E. J. 2019. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiology of Aging 75, pp. 136-149. (10.1016/j.neurobiolaging.2018.11.011)
2018
- Evans, C., Hvoslefeide, M., Thomas, R., Kidd, E. and Good, M. 2018. A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology. Neurobiology of Learning and Memory 149, pp. 46-57. (10.1016/j.nlm.2018.02.004)
2017
- Thomas, R., Alsaqati, M., Bice, J., Hvoslef-Eide, M., Good, M. and Kidd, E. 2017. Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology - implications for Alzheimer's disease. NeuroReport 28(15), pp. 963-968. (10.1097/WNR.0000000000000861)
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Lowe, A. P. P., Thomas, R. S., Nials, A. T., Kidd, E. J., Broadley, K. J. and Ford, W. R. 2017. Route of administration affects corticosteroid sensitivity of a combined ovalbumin and lipopolysaccharide model of asthma exacerbation in guinea-pigs. Journal of Pharmacology and Experimental Therapeutics 362(2), pp. 327-337. (10.1124/jpet.117.241927)
- Alsaqati, M., Thomas, R. S. and Kidd, E. 2017. Proteins involved in endocytosis are upregulated by ageing in the normal human brain: implications for the development of Alzheimer's disease. Journals of Gerontology, Series A 73(3), pp. 289-298., article number: glx135. (10.1093/gerona/glx135)
- Turner, D. L., Ford, W. R., Kidd, E. J., Broadley, K. J. and Powell, C. 2017. Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. European Journal of Pharmacology 801, pp. 79-85. (10.1016/j.ejphar.2017.03.004)
2016
- Thomas, R. S., Henson, A., Gerrish, A., Jones, L., Williams, J. and Kidd, E. J. 2016. Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease. BMC Neuroscience 17, article number: 50. (10.1186/s12868-016-0288-1)
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
2015
- Lowe, A. P. P., Thomas, R., Nials, A. T., Kidd, E., Broadley, K. and Ford, W. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Evans, R. L. et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407)
- Lowe, A., Broadley, K. J., Nials, A. T., Ford, W. R. and Kidd, E. J. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007)
2014
- Kidd, E. J., Hvoslef-Eide, M. and Thomas, R. S. 2014. Anti-amyloid precursor protein antibodies as a potential therapy for Alzheimer's disease [Abstract]. Neuroreport 25(3), pp. 145-145. (10.1097/01.wnr.0000443076.61006.22)
- Thomas, R. S. and Kidd, E. J. 2014. Caveolin-1 alters the amyloidogenic processing of amyloid precursor protein to amyloid-beta. Neuroreport -Oxford- 25(3), pp. 162-162. (10.1097/01.wnr.0000443076.61006.22)
2013
- Ford, W. R., Blair, A. E., Evans, R. L., John, E., Bugert, J. J., Broadley, K. J. and Kidd, E. J. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130)
- Broadley, K. J., Fehler, M., Ford, W. R. and Kidd, E. J. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034)
- Thomas, R. S., Hvoslef-Eide, M., Good, M. A. and Kidd, E. J. 2013. Inhibition of amyloid-[beta] production by anti-amyloid precursor protein antibodies in primary mouse cortical neurones. NeuroReport 24(18), pp. 1058-1061. (10.1097/WNR.0000000000000055)
2012
- Evans, R. L., Nials, A. T., Knowles, R. G., Kidd, E. J., Ford, W. R. and Broadley, K. J. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004)
- Turner, D. L. et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)
- Evans, B. A. J., Ham, J., Kidd, E. J. and Wilkinson, W. J. 2012. Third (2011) UK Purine Club annual symposium report [Editorial]. Purinergic Signalling 8(4), pp. 779. (10.1007/s11302-012-9297-4)
2011
- Thomas, R. S., Lelos, M. J., Good, M. A. and Kidd, E. J. 2011. Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochemical and Biophysical Research Communications 415(4), pp. 656-661. (10.1016/j.bbrc.2011.10.131)
- Natividad, G. M., Broadley, K. J., Kariuki, B., Kidd, E. J., Ford, W. R. and Simons, C. 2011. Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. Journal of Ethnopharmacology 137(1), pp. 808-816. (10.1016/j.jep.2011.06.042)
- Lelos, M. J., Thomas, R. S., Kidd, E. J. and Good, M. A. 2011. Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus-or action-outcome, associations in aged Tg2576 mice. Behavioral Neuroscience 125(3), pp. 412-425. (10.1037/a0023415)
- Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
- Thomas, R. S., Liddell, J. E. and Kidd, E. J. 2011. Anti-amyloid precursor protein immunoglobulins inhibit amyloid-β production by steric hindrance. Febs Journal 278(1), pp. 167-178. (10.1111/j.1742-4658.2010.07942.x)
2010
- Broadley, K. J., Blair, A. E., Kidd, E. J., Bugert, J. J. and Ford, W. R. 2010. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. Journal of Pharmacology and Experimental Therapeutics 335(3), pp. 681-692. (10.1124/jpet.110.171876)
- Fehler, M., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by beta-phenylethylamine. Naunyn Schmiedeburgs Archives of Pharmacology 382(4), pp. 385-398. (10.1007/s00210-010-0554-1)
- Turner, D. L., Ferrari, N., Ford, W. R., Kidd, E. J., Paquet, L., Renzi, P. and Broadley, K. J. 2010. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. European Journal of Pharmacology 641(2-3), pp. 213-219. (10.1016/j.ejphar.2010.05.025)
- Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulmonary Pharmacology and Therapeutics 23(4), pp. 300-307. (10.1016/j.pupt.2010.03.001)
2009
- Broadley, K. J. et al. 2009. Effects of dietary amines on the gut and its vasculature. British Journal of Nutrition 101(11), pp. 1645-1652. (10.1017/s0007114508123431)
- Alqallaf, S. M., Evans, B. A. J. and Kidd, E. J. 2009. Atypical P2X7 receptor pharmacology in two human osteoblast-like cell lines. British Journal of Pharmacology 156(7), pp. 1124-1135. (10.1111/j.1476-5381.2009.00119.x)
2008
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6), pp. 589-597. (10.1007/s00210-008-0331-6)
- Herbert, A. A., Kidd, E. J. and Broadley, K. J. 2008. Dietary trace amine-dependent vasoconstriction in porcine coronary artery. British Journal of Pharmacology 155(4), pp. 525-534. (10.1038/bjp.2008.286)
- Fernandez-Rodriguez, S., Ford, W. R., Broadley, K. J. and Kidd, E. J. 2008. Establishing the phenotype in novel acute and chronic murine models of allergic asthma. International Immunopharmacology 8(5), pp. 756-763. (10.1016/j.intimp.2008.01.025)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Protective role of beta 2- and beta 3-adrenoceptors at reperfusion in isolated rat heart. Journal of Molecular and Cellular Cardiology 44(4), pp. 719-719. (10.1016/j.yjmcc.2008.02.020)
2007
- Alqallaf, S., Kidd, E. and Evans, B. A. J. 2007. Modulation of P2X(7) receptors in human osteoblasts by oestrogen and corticosteroids. Presented at: 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Honolulu, HI, 2007, Vol. 22. Amer Soc Bone & Mineral Res pp. S145-S145.
- Alqallaf, S. M., Kidd, E. and Evans, B. A. J. 2007. Atypical pharmacology of P2X7 receptors in humanosteoblasts. Journal of Bone and Mineral Research (JBMR) 22(7), pp. 1135-1135.
2006
- Thomas, R. S., Liddell, J. E., Murphy, L. S., Pache, D. M. and Kidd, E. J. 2006. An antibody to the β-secretase cleavage site on amyloid-β-protein precursor inhibits amyloid-β production. Journal of Alzheimer's Disease 10(4), pp. 379-390.
- Kidd, E. J., Clark, J., Martin, T. and Yates, L. 2006. Radioligand binding and functional response of ligands for human recombinant adenosine A3 receptors. Autonomic and Autacoid Pharmacology 26(2), pp. 191-200. (10.1111/j.1474-8673.2006.00372.x)
2003
- Clark, J. H., Broadley, K. J., Hutcheson, I. R., Nicholson, R. I. and Kidd, E. J. 2003. Expression of adenosine receptors in MCF-7 human breast cancer cells [Abstract]. British Journal of Pharmacology 138, pp. U65.
- Connon, C. J., Young, R. D. and Kidd, E. J. 2003. P2X7 receptors are redistributed on human monocytes after pore formation in response to prolonged agonist exposure. Pharmacology 67(3), pp. 163-168. (10.1159/000067795)
2002
- Clark, J. H., Martin, T. J., Yates, L., Kidd, E. J., Nicholson, R. I. and Broadley, K. J. 2002. Characterisation of transfected human adenosine A3 receptors [Abstract]. British Journal of Pharmacology 136
- Clark, J. H., Broadley, K. J., Hutcheson, I. R., Nicholson, R. I. and Kidd, E. J. 2002. Adenosine receptor agonists mediate the phosphorylation of mitogen activated protein kinase (MAPK) in MCF-7 human breast cancer cells [Abstract]. British Journal of Pharmacology 135
2001
- Elneil, S., Skepper, J. N., Kidd, E. J., Williamson, J. G. and Ferguson, D. R. 2001. Distribution of P2X1 and P2X3 receptors in the rat and human urinary bladder. Pharmacology 63(2), pp. 120-128. (10.1159/000056122)
- Elneil, S., Skepper, J. N., Kidd, E. J., Williamson, J. G., Sellers, L. A. and Ferguson, D. R. 2001. Evidence for differential expression of P2X(1) and P2X(3) purine receptors in the detrusor muscle and urothelium, respectively, in the rat and human urinary bladder [Abstract]. British Journal of Pharmacology 133, pp. U11.
2000
- Souslova, V. et al. 2000. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X(3) receptors. Nature 407(6807), pp. 1015-1017. (10.1038/35039526)
- Kidd, E. J., Michel, A. D., Grahames, C. M., Dawe, H. and Humphrey, P. P. A. 2000. P2X(7) receptor expression and function in human THP-1 cells [Abstract]. British Journal of Pharmacology 131
- Hibell, A. D., Kidd, E. J., Chessell, I. P., Humphrey, P. P. A. and Michel, A. D. 2000. Apparent species differences in the kinetic properties of P2X(7) receptors. British Journal of Pharmacology 130(1), pp. 167-173. (10.1038/sj.bjp.0703302)
1998
- Kidd, E. J., Miller, K. J., Sansum, A. J. and Humphrey, P. P. A. 1998. Evidence for P2X(3) receptors in the developing rat brain. Neuroscience 87(3), pp. 533-539. (10.1016/S0306-4522(98)00294-2)
- Schindler, M. et al. 1998. Molecular cloning and functional characterization of a rat somatostatin sst(2(b)) receptor splice variant. British Journal of Pharmacology 125(1), pp. 209-217. (10.1038/sj.bjp.0702064)
- Eriksson, J., Bongenhielm, U., Kidd, E. J., Matthews, T. and Fried, K. 1998. Distribution of P2X(3) receptors in the rat trigeminal ganglion after interior alveolar nerve injury. Neuroscience Letters 254(1), pp. 37-40. (10.1016/S0304-3940(98)00656-9)
- Kidd, E. J., Schindler, M., Wyatt, M. A., Sellers, L. A. and Humphrey, P. P. A. 1998. Molecular cloning, expression and localisation of the rat somatostatin sst(2(b)) receptor splice variant in the rat gastric mucosa [Abstract]. British Journal of Pharmacology 123, pp. U82.
1997
- Simon, J., Kidd, E. J., Smith, F. M., Chessell, I. P., Murrell-Lagnado, R., Humphrey, P. P. A. and Barnard, E. A. 1997. Localization and functional expression of splice variants of the P2X(2) receptor. Molecular Pharmacology 52(2), pp. 237-248.
1996
- McKeen, E. S., Feniuk, W., Michel, A. D., Kidd, E. J. and Humphrey, P. P. A. 1996. Identification and characterisation of heterogeneous somatostatin binding sites in rat distal colonic mucosa. Naunyn Schmiedeburgs Archives of Pharmacology 354(5), pp. 543-549. (10.1007/BF00170826)
- Holloway, S., Feniuk, W., Kidd, E. J. and Humphrey, P. P. A. 1996. Autoradiographical studies with the somatostatin sst(2)-receptor-selective novel radioligand [I-125]-BIM-23027 in rat brain [Abstract]. British Journal of Pharmacology 117(S1), pp. 320P. (10.1111/j.1476-5381.1996.tb17244.x)
- Holloway, S., Feniuk, W., Kidd, E. J. and Humphrey, P. P. A. 1996. A quantitative autoradiographical study on the distribution of somatostatin sst(2) receptors in the rat central nervous system using [I-125]-BIM-23027. Neuropharmacology 35(8), pp. 1109-1120. (10.1016/S0028-3908(96)00082-2)
1995
- Kidd, E. J., Grahames, C. B. A., Simon, J., Michel, A. D., Barnard, E. A. and Humphrey, P. P. A. 1995. Localization of P2X purinoceptor transcripts in the rat nervous system. Molecular Pharmacology 48(4), pp. 569-573.
- Grahames, C. B. A., Kidd, E. J., Simon, J., Michel, A. D., Barnard, E. A. and Humphrey, P. P. A. 1995. Localization of P-2X-Purinoceptor Transcripts in the Rat Nervous-System [Abstract]. British Journal of Pharmacology 116(S1), pp. 138P. (10.1111/j.1476-5381.1995.tb16904.x)
- Kidd, E. J., Michel, A. D. and Humphrey, P. P. A. 1995. Autoradiographic distribution of [3H]l-NG-Nitro-arginine binding in rat brain. Neuropharmacology 34(1), pp. 63-73. (10.1016/0028-3908(94)00132-C)
1994
- Kidd, E., Michel, A. D. and Humphrey, P. P. A. 1994. Regional autoradiographic localization of high-affinity [H-3] alpha,beta-methylene ATP binding-sites in the rat-brain [Abstract]. British Journal of Pharmacology 112, pp. U165.
- Jolas, T. et al. 1994. Central Pre- and Postsynaptic 5-HTIA Receptors in Rats Treated Chronically With a Novel Antidepressant, Cericlamine. Journal of Pharmacology and Experimental Therapeutics 268(3), pp. 1432-1443.
1993
- Kidd, E. J., Michel, A. D. and Humphrey, P. P. A. 1993. Regional autoradiographic localization of nitric-oxide synthase in the rat-brain using [H-3] nitroarginine [Abstract]. British Journal of Pharmacology 110(S1), article number: P81. (10.1111/j.1476-5381.1993.tb16292.x)
- Kidd, E. J., Levy, J. C., Nielsen, M., Hamon, M. and Gozlan, H. 1993. Characterisation of the non-5-HT3 high-affinity ‘R’ binding site for (R)-zacopride in brain and other tissues. European Journal of Pharmacology: Molecular Pharmacology 247(1), pp. 45-56. (10.1016/0922-4106(93)90136-W)
- Kidd, E. J. et al. 1993. 5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals. Brain Research 612(1-2), pp. 289-298. (10.1016/0006-8993(93)91674-H)
- Jolas, T. et al. 1993. (−)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn Schmiedeburgs Archives of Pharmacology 347(5), pp. 453-463. (10.1007/BF00166735)
- Kidd, E. J. et al. 1993. New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors. Journal of Pharmacology and Experimental Therapeutics 264(2), pp. 863-872.
1992
- Kidd, E. J., Bouchelet de Vendegies, I., Levy, J. C., Hamon, M. and Gozlan, H. 1992. The potent 5-HT3 receptor antagonist (R)-zacopride labels an additional high affinity site in the central nervous system. European Journal of Pharmacology 211(1), pp. 133-136. (10.1016/0014-2999(92)90276-A)
- Kidd, E. J., Laporte, A. M., Langlois, X., Lombard, M. C., Gozlan, H. and Hamon, M. 1992. Differential Localization and Regulation of Central 5-HT(1A) and 5-HT(3) Receptors. Presented at: Serotonin 9̀1 Conference, Birmingham, UK, 14-17 July 1991 Presented at Bradley, P. B. and Handley, S. L. eds.Serotonin, CNS Receptors and Brain Function: Proceedings of the Serotonin 9̀1 Conference held in Birmingham, UK, on 14-17 July 1991. Cospar Colloquia Series Vol. 85. Oxford: Pergamon Press pp. 13-27.
1991
- Kidd, E., Garratt, J. C. and Marsden, C. A. 1991. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. European Journal of Pharmacology 200(1), pp. 131-139. (10.1016/0014-2999(91)90675-G)
- Garratt, J. C., Kidd, E., Wright, I. K. and Marsden, C. A. 1991. Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. European Journal of Pharmacology 199(3), pp. 349-355. (10.1016/0014-2999(91)90499-G)
- Hamon, M., Kidd, E. J., Gozlan, H. and Martin, P. 1991. Is 5-HT3 receptor blockade able to prevent dopaminergic activation by stress. Presented at: 5th World Congress of Biological Psychiatry, Florence, Italy, 9-14 June 1991 Presented at Racagni, G., Brunello, N. and Fukuda, T. eds.Biological Psychiatry: Proceedings of the 5th World Congress of Biological Psychiatry, Florence, 9-14 June 1991, Vol. 2. International congress series Vol. 968. Amsterdam: Excerpta Medica pp. 706-709.
- Hamon, M., Lanfumey, L., Hajdahmane, S., Jolas, T., Kidd, E. J., Bolanos, F. and Gozlan, H. 1991. Adaptation of central 5-HT1A receptors after chronic antidepressant treatment in rats. Presented at: 5th World Congress of Biological Psychiatry, Florence, Italy, 9-14 June 1991 Presented at Racagni, G., Brunello, N. and Fukuda, T. eds.Biological Psychiatry: Proceedings of the 5th World Congress of Biological Psychiatry, Florence, 9-14 June 1991, Vol. 1. International congress series Vol. 968. Amsterdam: Excerpta Medica pp. 297-300.
1990
- Kidd, E. J., Leysen, J. E. and Marsden, C. A. 1990. Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo. Journal of Neuroscience Methods 34(1-3), pp. 91-98. (10.1016/0165-0270(90)90046-I)
- Kidd, E. J., Leysen, J. E. and Marsden, C. A. 1990. Cortical 5-HT release in vivo after repeated treatment with a 5-HT2 agonist and a thyrotrophin releasing hormone analogue [Poster]. European Journal of Pharmacology 183(5), pp. 1948-1949. (10.1016/0014-2999(90)92296-U)
- Schotte, A. G., Kidd, E. J., Marsden, C. A. and Leysen, J. E. 1990. Autoradiographic measurement of 5-HT2 and 5-HT1C receptors in rat brain after chronic treatment with ritanserin and DOM [Poster]. European Journal of Pharmacology 183(5), pp. 1957-1958. (10.1016/0014-2999(90)92306-4)
1988
- Mir, A. K., Hibert, M., Tricklebank, M. D., Middlemiss, D. N., Kidd, E. J. and Fozard, J. R. 1988. MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. European Journal of Pharmacology 149(1-2), pp. 107-120. (10.1016/0014-2999(88)90048-9)
1987
- Tricklebank, M. D., Neill, J., Kidd, E. J. and Fozard, J. R. 1987. Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. European Journal of Pharmacology 133(1), pp. 47-56. (10.1016/0014-2999(87)90204-4)
1970
- Almutairi, J. A. and Kidd, E. J. 1970. Biological sex disparities in Alzheimer's disease. In: Current Topics in Behavioral Neurosciences. Berlin:, (10.1007/7854_2024_545)
Articles
- Andrews, R., Lacey, A., Bache, K. and Kidd, E. J. 2024. The role of menopausal symptoms on future health and longevity: A systematic scoping review of longitudinal evidence. Maturitas: An international journal of midlife health and beyond 190, article number: 108130. (10.1016/j.maturitas.2024.108130)
- Canonica, T., Kidd, E. J., Gibbins, D., Lana-Elola, E., Fisher, E. M. C., Tybulewicz, V. L. J. and Good, M. 2024. Dissecting the contribution of human chromosome 21 syntenic regions to recognition memory processes in adult and aged mouse models of Down syndrome. Frontiers in Behavioral Neuroscience 18, article number: 1428146. (10.3389/fnbeh.2024.1428146)
- Alsaqati, M., Thomas, R. S. and Kidd, E. J. 2023. Upregulation of endocytic protein expression in the Alzheimer's disease male human brain. Aging Brain 4, article number: 100084. (10.1016/j.nbas.2023.100084)
- Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Hamilton, D. A., Kidd, E. and Metzler-Baddeley, C. 2020. Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults. Neurobiology of Aging 94, pp. 298-310. (10.1016/j.neurobiolaging.2020.06.014)
- Evans, C. E. et al. 2020. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease. Acta Neuropathologica 139, pp. 485-502. (10.1007/s00401-019-02098-6)
- Mole, J. P., Fasano, F., Evans, J., Sims, R., Kidd, E., Aggleton, J. and Metzler-Baddeley, C. 2020. APOE-e4-related differences in left thalamic microstructure in cognitively healthy adults. Scientific Reports 10, article number: 19787. (10.1038/s41598-020-75992-9)
- Metzler-Baddeley, C. et al. 2019. Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure. NeuroImage 189, pp. 793-803. (10.1016/j.neuroimage.2019.02.007)
- Evans, C. E., Thomas, R. S., Freeman, T. J., Hvoslef-Eide, M., Good, M. A. and Kidd, E. J. 2019. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiology of Aging 75, pp. 136-149. (10.1016/j.neurobiolaging.2018.11.011)
- Evans, C., Hvoslefeide, M., Thomas, R., Kidd, E. and Good, M. 2018. A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology. Neurobiology of Learning and Memory 149, pp. 46-57. (10.1016/j.nlm.2018.02.004)
- Thomas, R., Alsaqati, M., Bice, J., Hvoslef-Eide, M., Good, M. and Kidd, E. 2017. Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology - implications for Alzheimer's disease. NeuroReport 28(15), pp. 963-968. (10.1097/WNR.0000000000000861)
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Lowe, A. P. P., Thomas, R. S., Nials, A. T., Kidd, E. J., Broadley, K. J. and Ford, W. R. 2017. Route of administration affects corticosteroid sensitivity of a combined ovalbumin and lipopolysaccharide model of asthma exacerbation in guinea-pigs. Journal of Pharmacology and Experimental Therapeutics 362(2), pp. 327-337. (10.1124/jpet.117.241927)
- Alsaqati, M., Thomas, R. S. and Kidd, E. 2017. Proteins involved in endocytosis are upregulated by ageing in the normal human brain: implications for the development of Alzheimer's disease. Journals of Gerontology, Series A 73(3), pp. 289-298., article number: glx135. (10.1093/gerona/glx135)
- Turner, D. L., Ford, W. R., Kidd, E. J., Broadley, K. J. and Powell, C. 2017. Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. European Journal of Pharmacology 801, pp. 79-85. (10.1016/j.ejphar.2017.03.004)
- Thomas, R. S., Henson, A., Gerrish, A., Jones, L., Williams, J. and Kidd, E. J. 2016. Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease. BMC Neuroscience 17, article number: 50. (10.1186/s12868-016-0288-1)
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
- Lowe, A. P. P., Thomas, R., Nials, A. T., Kidd, E., Broadley, K. and Ford, W. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Evans, R. L. et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407)
- Lowe, A., Broadley, K. J., Nials, A. T., Ford, W. R. and Kidd, E. J. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007)
- Kidd, E. J., Hvoslef-Eide, M. and Thomas, R. S. 2014. Anti-amyloid precursor protein antibodies as a potential therapy for Alzheimer's disease [Abstract]. Neuroreport 25(3), pp. 145-145. (10.1097/01.wnr.0000443076.61006.22)
- Thomas, R. S. and Kidd, E. J. 2014. Caveolin-1 alters the amyloidogenic processing of amyloid precursor protein to amyloid-beta. Neuroreport -Oxford- 25(3), pp. 162-162. (10.1097/01.wnr.0000443076.61006.22)
- Ford, W. R., Blair, A. E., Evans, R. L., John, E., Bugert, J. J., Broadley, K. J. and Kidd, E. J. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130)
- Broadley, K. J., Fehler, M., Ford, W. R. and Kidd, E. J. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034)
- Thomas, R. S., Hvoslef-Eide, M., Good, M. A. and Kidd, E. J. 2013. Inhibition of amyloid-[beta] production by anti-amyloid precursor protein antibodies in primary mouse cortical neurones. NeuroReport 24(18), pp. 1058-1061. (10.1097/WNR.0000000000000055)
- Evans, R. L., Nials, A. T., Knowles, R. G., Kidd, E. J., Ford, W. R. and Broadley, K. J. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004)
- Turner, D. L. et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)
- Evans, B. A. J., Ham, J., Kidd, E. J. and Wilkinson, W. J. 2012. Third (2011) UK Purine Club annual symposium report [Editorial]. Purinergic Signalling 8(4), pp. 779. (10.1007/s11302-012-9297-4)
- Thomas, R. S., Lelos, M. J., Good, M. A. and Kidd, E. J. 2011. Clathrin-mediated endocytic proteins are upregulated in the cortex of the Tg2576 mouse model of Alzheimer's disease-like amyloid pathology. Biochemical and Biophysical Research Communications 415(4), pp. 656-661. (10.1016/j.bbrc.2011.10.131)
- Natividad, G. M., Broadley, K. J., Kariuki, B., Kidd, E. J., Ford, W. R. and Simons, C. 2011. Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. Journal of Ethnopharmacology 137(1), pp. 808-816. (10.1016/j.jep.2011.06.042)
- Lelos, M. J., Thomas, R. S., Kidd, E. J. and Good, M. A. 2011. Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus-or action-outcome, associations in aged Tg2576 mice. Behavioral Neuroscience 125(3), pp. 412-425. (10.1037/a0023415)
- Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
- Thomas, R. S., Liddell, J. E. and Kidd, E. J. 2011. Anti-amyloid precursor protein immunoglobulins inhibit amyloid-β production by steric hindrance. Febs Journal 278(1), pp. 167-178. (10.1111/j.1742-4658.2010.07942.x)
- Broadley, K. J., Blair, A. E., Kidd, E. J., Bugert, J. J. and Ford, W. R. 2010. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. Journal of Pharmacology and Experimental Therapeutics 335(3), pp. 681-692. (10.1124/jpet.110.171876)
- Fehler, M., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by beta-phenylethylamine. Naunyn Schmiedeburgs Archives of Pharmacology 382(4), pp. 385-398. (10.1007/s00210-010-0554-1)
- Turner, D. L., Ferrari, N., Ford, W. R., Kidd, E. J., Paquet, L., Renzi, P. and Broadley, K. J. 2010. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. European Journal of Pharmacology 641(2-3), pp. 213-219. (10.1016/j.ejphar.2010.05.025)
- Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulmonary Pharmacology and Therapeutics 23(4), pp. 300-307. (10.1016/j.pupt.2010.03.001)
- Broadley, K. J. et al. 2009. Effects of dietary amines on the gut and its vasculature. British Journal of Nutrition 101(11), pp. 1645-1652. (10.1017/s0007114508123431)
- Alqallaf, S. M., Evans, B. A. J. and Kidd, E. J. 2009. Atypical P2X7 receptor pharmacology in two human osteoblast-like cell lines. British Journal of Pharmacology 156(7), pp. 1124-1135. (10.1111/j.1476-5381.2009.00119.x)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6), pp. 589-597. (10.1007/s00210-008-0331-6)
- Herbert, A. A., Kidd, E. J. and Broadley, K. J. 2008. Dietary trace amine-dependent vasoconstriction in porcine coronary artery. British Journal of Pharmacology 155(4), pp. 525-534. (10.1038/bjp.2008.286)
- Fernandez-Rodriguez, S., Ford, W. R., Broadley, K. J. and Kidd, E. J. 2008. Establishing the phenotype in novel acute and chronic murine models of allergic asthma. International Immunopharmacology 8(5), pp. 756-763. (10.1016/j.intimp.2008.01.025)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Protective role of beta 2- and beta 3-adrenoceptors at reperfusion in isolated rat heart. Journal of Molecular and Cellular Cardiology 44(4), pp. 719-719. (10.1016/j.yjmcc.2008.02.020)
- Alqallaf, S. M., Kidd, E. and Evans, B. A. J. 2007. Atypical pharmacology of P2X7 receptors in humanosteoblasts. Journal of Bone and Mineral Research (JBMR) 22(7), pp. 1135-1135.
- Thomas, R. S., Liddell, J. E., Murphy, L. S., Pache, D. M. and Kidd, E. J. 2006. An antibody to the β-secretase cleavage site on amyloid-β-protein precursor inhibits amyloid-β production. Journal of Alzheimer's Disease 10(4), pp. 379-390.
- Kidd, E. J., Clark, J., Martin, T. and Yates, L. 2006. Radioligand binding and functional response of ligands for human recombinant adenosine A3 receptors. Autonomic and Autacoid Pharmacology 26(2), pp. 191-200. (10.1111/j.1474-8673.2006.00372.x)
- Clark, J. H., Broadley, K. J., Hutcheson, I. R., Nicholson, R. I. and Kidd, E. J. 2003. Expression of adenosine receptors in MCF-7 human breast cancer cells [Abstract]. British Journal of Pharmacology 138, pp. U65.
- Connon, C. J., Young, R. D. and Kidd, E. J. 2003. P2X7 receptors are redistributed on human monocytes after pore formation in response to prolonged agonist exposure. Pharmacology 67(3), pp. 163-168. (10.1159/000067795)
- Clark, J. H., Martin, T. J., Yates, L., Kidd, E. J., Nicholson, R. I. and Broadley, K. J. 2002. Characterisation of transfected human adenosine A3 receptors [Abstract]. British Journal of Pharmacology 136
- Clark, J. H., Broadley, K. J., Hutcheson, I. R., Nicholson, R. I. and Kidd, E. J. 2002. Adenosine receptor agonists mediate the phosphorylation of mitogen activated protein kinase (MAPK) in MCF-7 human breast cancer cells [Abstract]. British Journal of Pharmacology 135
- Elneil, S., Skepper, J. N., Kidd, E. J., Williamson, J. G. and Ferguson, D. R. 2001. Distribution of P2X1 and P2X3 receptors in the rat and human urinary bladder. Pharmacology 63(2), pp. 120-128. (10.1159/000056122)
- Elneil, S., Skepper, J. N., Kidd, E. J., Williamson, J. G., Sellers, L. A. and Ferguson, D. R. 2001. Evidence for differential expression of P2X(1) and P2X(3) purine receptors in the detrusor muscle and urothelium, respectively, in the rat and human urinary bladder [Abstract]. British Journal of Pharmacology 133, pp. U11.
- Souslova, V. et al. 2000. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X(3) receptors. Nature 407(6807), pp. 1015-1017. (10.1038/35039526)
- Kidd, E. J., Michel, A. D., Grahames, C. M., Dawe, H. and Humphrey, P. P. A. 2000. P2X(7) receptor expression and function in human THP-1 cells [Abstract]. British Journal of Pharmacology 131
- Hibell, A. D., Kidd, E. J., Chessell, I. P., Humphrey, P. P. A. and Michel, A. D. 2000. Apparent species differences in the kinetic properties of P2X(7) receptors. British Journal of Pharmacology 130(1), pp. 167-173. (10.1038/sj.bjp.0703302)
- Kidd, E. J., Miller, K. J., Sansum, A. J. and Humphrey, P. P. A. 1998. Evidence for P2X(3) receptors in the developing rat brain. Neuroscience 87(3), pp. 533-539. (10.1016/S0306-4522(98)00294-2)
- Schindler, M. et al. 1998. Molecular cloning and functional characterization of a rat somatostatin sst(2(b)) receptor splice variant. British Journal of Pharmacology 125(1), pp. 209-217. (10.1038/sj.bjp.0702064)
- Eriksson, J., Bongenhielm, U., Kidd, E. J., Matthews, T. and Fried, K. 1998. Distribution of P2X(3) receptors in the rat trigeminal ganglion after interior alveolar nerve injury. Neuroscience Letters 254(1), pp. 37-40. (10.1016/S0304-3940(98)00656-9)
- Kidd, E. J., Schindler, M., Wyatt, M. A., Sellers, L. A. and Humphrey, P. P. A. 1998. Molecular cloning, expression and localisation of the rat somatostatin sst(2(b)) receptor splice variant in the rat gastric mucosa [Abstract]. British Journal of Pharmacology 123, pp. U82.
- Simon, J., Kidd, E. J., Smith, F. M., Chessell, I. P., Murrell-Lagnado, R., Humphrey, P. P. A. and Barnard, E. A. 1997. Localization and functional expression of splice variants of the P2X(2) receptor. Molecular Pharmacology 52(2), pp. 237-248.
- McKeen, E. S., Feniuk, W., Michel, A. D., Kidd, E. J. and Humphrey, P. P. A. 1996. Identification and characterisation of heterogeneous somatostatin binding sites in rat distal colonic mucosa. Naunyn Schmiedeburgs Archives of Pharmacology 354(5), pp. 543-549. (10.1007/BF00170826)
- Holloway, S., Feniuk, W., Kidd, E. J. and Humphrey, P. P. A. 1996. Autoradiographical studies with the somatostatin sst(2)-receptor-selective novel radioligand [I-125]-BIM-23027 in rat brain [Abstract]. British Journal of Pharmacology 117(S1), pp. 320P. (10.1111/j.1476-5381.1996.tb17244.x)
- Holloway, S., Feniuk, W., Kidd, E. J. and Humphrey, P. P. A. 1996. A quantitative autoradiographical study on the distribution of somatostatin sst(2) receptors in the rat central nervous system using [I-125]-BIM-23027. Neuropharmacology 35(8), pp. 1109-1120. (10.1016/S0028-3908(96)00082-2)
- Kidd, E. J., Grahames, C. B. A., Simon, J., Michel, A. D., Barnard, E. A. and Humphrey, P. P. A. 1995. Localization of P2X purinoceptor transcripts in the rat nervous system. Molecular Pharmacology 48(4), pp. 569-573.
- Grahames, C. B. A., Kidd, E. J., Simon, J., Michel, A. D., Barnard, E. A. and Humphrey, P. P. A. 1995. Localization of P-2X-Purinoceptor Transcripts in the Rat Nervous-System [Abstract]. British Journal of Pharmacology 116(S1), pp. 138P. (10.1111/j.1476-5381.1995.tb16904.x)
- Kidd, E. J., Michel, A. D. and Humphrey, P. P. A. 1995. Autoradiographic distribution of [3H]l-NG-Nitro-arginine binding in rat brain. Neuropharmacology 34(1), pp. 63-73. (10.1016/0028-3908(94)00132-C)
- Kidd, E., Michel, A. D. and Humphrey, P. P. A. 1994. Regional autoradiographic localization of high-affinity [H-3] alpha,beta-methylene ATP binding-sites in the rat-brain [Abstract]. British Journal of Pharmacology 112, pp. U165.
- Jolas, T. et al. 1994. Central Pre- and Postsynaptic 5-HTIA Receptors in Rats Treated Chronically With a Novel Antidepressant, Cericlamine. Journal of Pharmacology and Experimental Therapeutics 268(3), pp. 1432-1443.
- Kidd, E. J., Michel, A. D. and Humphrey, P. P. A. 1993. Regional autoradiographic localization of nitric-oxide synthase in the rat-brain using [H-3] nitroarginine [Abstract]. British Journal of Pharmacology 110(S1), article number: P81. (10.1111/j.1476-5381.1993.tb16292.x)
- Kidd, E. J., Levy, J. C., Nielsen, M., Hamon, M. and Gozlan, H. 1993. Characterisation of the non-5-HT3 high-affinity ‘R’ binding site for (R)-zacopride in brain and other tissues. European Journal of Pharmacology: Molecular Pharmacology 247(1), pp. 45-56. (10.1016/0922-4106(93)90136-W)
- Kidd, E. J. et al. 1993. 5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals. Brain Research 612(1-2), pp. 289-298. (10.1016/0006-8993(93)91674-H)
- Jolas, T. et al. 1993. (−)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn Schmiedeburgs Archives of Pharmacology 347(5), pp. 453-463. (10.1007/BF00166735)
- Kidd, E. J. et al. 1993. New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors. Journal of Pharmacology and Experimental Therapeutics 264(2), pp. 863-872.
- Kidd, E. J., Bouchelet de Vendegies, I., Levy, J. C., Hamon, M. and Gozlan, H. 1992. The potent 5-HT3 receptor antagonist (R)-zacopride labels an additional high affinity site in the central nervous system. European Journal of Pharmacology 211(1), pp. 133-136. (10.1016/0014-2999(92)90276-A)
- Kidd, E., Garratt, J. C. and Marsden, C. A. 1991. Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. European Journal of Pharmacology 200(1), pp. 131-139. (10.1016/0014-2999(91)90675-G)
- Garratt, J. C., Kidd, E., Wright, I. K. and Marsden, C. A. 1991. Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. European Journal of Pharmacology 199(3), pp. 349-355. (10.1016/0014-2999(91)90499-G)
- Kidd, E. J., Leysen, J. E. and Marsden, C. A. 1990. Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo. Journal of Neuroscience Methods 34(1-3), pp. 91-98. (10.1016/0165-0270(90)90046-I)
- Kidd, E. J., Leysen, J. E. and Marsden, C. A. 1990. Cortical 5-HT release in vivo after repeated treatment with a 5-HT2 agonist and a thyrotrophin releasing hormone analogue [Poster]. European Journal of Pharmacology 183(5), pp. 1948-1949. (10.1016/0014-2999(90)92296-U)
- Schotte, A. G., Kidd, E. J., Marsden, C. A. and Leysen, J. E. 1990. Autoradiographic measurement of 5-HT2 and 5-HT1C receptors in rat brain after chronic treatment with ritanserin and DOM [Poster]. European Journal of Pharmacology 183(5), pp. 1957-1958. (10.1016/0014-2999(90)92306-4)
- Mir, A. K., Hibert, M., Tricklebank, M. D., Middlemiss, D. N., Kidd, E. J. and Fozard, J. R. 1988. MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. European Journal of Pharmacology 149(1-2), pp. 107-120. (10.1016/0014-2999(88)90048-9)
- Tricklebank, M. D., Neill, J., Kidd, E. J. and Fozard, J. R. 1987. Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. European Journal of Pharmacology 133(1), pp. 47-56. (10.1016/0014-2999(87)90204-4)
Book sections
- Almutairi, J. A. and Kidd, E. J. 1970. Biological sex disparities in Alzheimer's disease. In: Current Topics in Behavioral Neurosciences. Berlin:, (10.1007/7854_2024_545)
Conferences
- Alqallaf, S., Kidd, E. and Evans, B. A. J. 2007. Modulation of P2X(7) receptors in human osteoblasts by oestrogen and corticosteroids. Presented at: 29th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Honolulu, HI, 2007, Vol. 22. Amer Soc Bone & Mineral Res pp. S145-S145.
- Kidd, E. J., Laporte, A. M., Langlois, X., Lombard, M. C., Gozlan, H. and Hamon, M. 1992. Differential Localization and Regulation of Central 5-HT(1A) and 5-HT(3) Receptors. Presented at: Serotonin 9̀1 Conference, Birmingham, UK, 14-17 July 1991 Presented at Bradley, P. B. and Handley, S. L. eds.Serotonin, CNS Receptors and Brain Function: Proceedings of the Serotonin 9̀1 Conference held in Birmingham, UK, on 14-17 July 1991. Cospar Colloquia Series Vol. 85. Oxford: Pergamon Press pp. 13-27.
- Hamon, M., Kidd, E. J., Gozlan, H. and Martin, P. 1991. Is 5-HT3 receptor blockade able to prevent dopaminergic activation by stress. Presented at: 5th World Congress of Biological Psychiatry, Florence, Italy, 9-14 June 1991 Presented at Racagni, G., Brunello, N. and Fukuda, T. eds.Biological Psychiatry: Proceedings of the 5th World Congress of Biological Psychiatry, Florence, 9-14 June 1991, Vol. 2. International congress series Vol. 968. Amsterdam: Excerpta Medica pp. 706-709.
- Hamon, M., Lanfumey, L., Hajdahmane, S., Jolas, T., Kidd, E. J., Bolanos, F. and Gozlan, H. 1991. Adaptation of central 5-HT1A receptors after chronic antidepressant treatment in rats. Presented at: 5th World Congress of Biological Psychiatry, Florence, Italy, 9-14 June 1991 Presented at Racagni, G., Brunello, N. and Fukuda, T. eds.Biological Psychiatry: Proceedings of the 5th World Congress of Biological Psychiatry, Florence, 9-14 June 1991, Vol. 1. International congress series Vol. 968. Amsterdam: Excerpta Medica pp. 297-300.
Ymchwil
Research interests
I am interested in understanding how alzheimer's disease develops and how it could be treated. Research in my laboratory is concentrated on cellular and molecular pharmacology to understand more about the mechanisms underlying several disease processes, with the ultimate aim of improving or developing new therapies for these conditions. We use a variety of human cell lines, animal models and human tissue and many biochemical and molecular biological techniques to investigate cell function.
- Ageing in the brain
- Alzheimer's disease
- Development of models of respiratory disease
Director of Postgraduate Research Studies for the School of Pharmacy and Pharmaceutical Sciences
Novel therapeutic antibodies for Alzheimer's disease
Alzheimer's disease is a progressive neurodegenerative condition with very limited treatment and no cure. The incidence of this disease is rising worldwide as the population ages, as are the associated socioeconomic costs. There is therefore much interest in developing novel therapies. We proposed a 'blue skies' approach to devise an antibody-based therapy which would potentially halt the disease process and possibly also be used as a preventative treatment in high risk individuals. This approach differs to many others under investigation by other groups and companies worldwide and could be used in combination with other therapies to treat this debilitating and distressing disease.
Investigating how changes in endocytosis could give rise to Alzheimer's disease
It is highly likely that many factors contribute to the development of Alzheimer's disease. We are interested in changes in endocytosis, the process whereby cells take up material from the extracellular space. These changes have been identified in patients' brains and also as susceptibility genes which give a small, increased risk of developing Alzheimer's disease. We have manipulated a variety of proteins intimately involved in the two main types of endocytosis, clathrin-dependent and caveolin-dependent. Altering the levels of these proteins has contrasting effects on the levels of a number of proteins implicated in the pathogenesis of Alzheimer's disease.
Understanding the contribution of ageing to Alzheimer's disease
The main risk factor for Alzheimer's disease is increasing age but we still do not understand how ageing leads to the disease. Since endocytosis is known to be affected in Alzheimer's disease, we are examining how the expression of endocytic proteins is affected by ageing in mouse and human brains. We are investigating this using human brain samples from young, middle-aged and older people and comparing these results to those from people with Alzheimer's disease. We are also using a series of mouse brains from different ages and comparing normal mice and transgenic mice which are a model for Alzheimer's disease.
Development of asthma models
I am involved in the development of animal models of respiratory disease which more closely the mimic human disease. Such models will allow us to learn more about the pathophysiology of these conditions and may lead to novel or improved therapeutic drugs.
Collaborators
Postdoctoral research associates
- Dr Mouhamed Alsaqati (funded by BRACE)
School of Pharmacy and Pharmaceutical Sciences
- Prof Ken Broadley, Pharmacology & Physiology
- Dr Will Ford, Pharmacology & Physiology
- Dr Julia Gee, Pharmacology & Physiology
- Prof Arwyn Jones, Pharmaceutical Biology
- Dr Emma Lane, Pharmacology & Physiology
- Dr Rhian Thomas, Pharmcology & Physiology
Cardiff University
- Dr Dominic Dwyer, Psychology.
- Prof Mark Good, Psychology
- Prof Lesley Jones, Institute of Medical Genetics
- Prof Paul Kemp, Biosciences
- Dr Colin Powell, Child health
- Prof Daniel Ricardi, Biosciences
- Prof. Julie Williams, Psychological Medicine
- Dr Nigel Willams, Psychological Medicine
Key expertise
- Western blotting
- Immunocytochemistry and immunohistochemistry with bright field and fluorescent microscopy including laser scanning confocal microscopy
- ELISA
- Cell culture techniques
- RT-PCR
- In situ hybridisation
- In vivo measurements of lung function
- sIRNA
Current research students
- Charles Evans
- Adam Brelsford
Previous research students
- Dr Zakky Cholisoh
- Dr Ceri Davies
- Dr Alex Lowe
- Dr Martha Hvoslef-Eide
- Dr Gaudencio Natividad
- Dr Jill Clark
- Dr Sofia Fernandez-Rodriguez
- Dr Martina Fehler
- Dr Peter Penson
- Dr Rhys Evans
- Dr Dawn Turner
- Dr Alex Henson
- Dr Mohammed Al-Qallaf
Projects
- Novel therapies and alzheimer's disease
- Endocytosis and Alzheimer's disease
- Ageing and alzheimer's disease
- Development of models of respiratory disease.
- Studies on the exacerbation of pulmonary inflammation by viral infection
Addysgu
- PH1122 The role of the pharmacist in professional practice
- PH1124 Human body systems
- PH1125 Chemical and biological properties of drug molecules
- PH2110 Clinical & professional pharmacy
- PH2112 Principles of drug design
- PH2113 Diseases and drugs I
- PH3110 Optimisation of pharmaceutical care
- PH3113 Diseases and drugs II
- PH4116 Pharmacy research or scholarship project
- PH4117 Pharmaceutical sciences, pharmacy practice and the population
- PH4118 Pharmaceutical sciences, pharmacy practice and the patient
Bywgraffiad
Career profile
I graduated with a degree in Pharmacology from the University of Bath in 1987 and then went to the Department of Physiology and Pharmacology at Nottingham University to do a Ph.D. on the "Functional Adaptation of 5-HT Receptors" under the supervision of Prof. Charles Marsden. Having graduated from Nottingham in 1990, I went to Paris to work for two years as a postdoctoral research associate in Dr Michel Hamon's INSERM-funded laboratory. In 1992 I returned to the U.K. to work as a Postdoctoral Research Associate and subsequently as a Senior Postdoctoral Research Associate for Prof. Pat Humphrey in the Glaxo Institute for Applied Pharmacology in the Department of Pharmacology at Cambridge University. In 1999, I joined the School of Pharmacy and Pharmaceutical Sciences at Cardiff University as a lecturer and was promoted to senior lecturer in 2009, and promoted again to Reader in 2013.
Scientific and professional service
External examiner in Pharmacology, University of East Anglia, MPharm degree.
Anrhydeddau a dyfarniadau
- Awarded Fellowship of the British Pharmacological Society (2021)
- Jointly awarded the Student Union’s Enriching Student Life Award for Personal Tutor of the Year (2020)
- Jointly awarded the Student Union’s overall Enriching Student Life Award (2020)
Aelodaethau proffesiynol
- Biochemical Society
- Alzheimer's Society
- British Neuroscience Association
- British Pharmacological Society
- Royal Pharmaceutical Society of Great Britain Academic Pharmacy Group
- Alzheimers Association
Safleoedd academaidd blaenorol
Previous appointments
- Reader in the School of Pharmacy and Pharmaceutical Sciences, 2013 – 2021
- Senior Lecturer in the School of Pharmacy and Pharmaceutical Sciences, 2009-2013
- Lecturer in the School of Pharmacy and Pharmaceutical Sciences, 1999 – 2009
- Senior Postdoctoral Research Associate, University of Cambridge, 1997–1999
- Postdoctoral Research Associate, University of Cambridge, 1992–1997
- Postdoctoral Research Fellow, INSERM Unité 288, Paris, 1990–1992
Pwyllgorau ac adolygu
University Graduate College Board
Meysydd goruchwyliaeth
I am interested in supervising students in the areas of:
- The role of age and biological sex on the development of Alzheimer's disease
- Management of depression and anti-psychotic use in patients with Alzheimer's disease
- The influence of oestrogen exposure and the menopause on longevity
Prosiectau'r gorffennol
- Graddiodd Dr Jill Clark, 'Effeithiau adenosine ar gelloedd canser y fron dynol', yn 2004.
- Graddiodd Dr Sofia Fernandez-Rodriguez, 'Llwybrau signalau celloedd yn ymatebion llidiol y llwybrau anadlu mewn asthma', yn 2006.
- Graddiodd Dr Mahmood Al-Qallaf, 'Nodweddu derbynyddion P2X7 mewn osteoblasts dynol a modiwleiddio gan estrogen', yn 2008.
- Graddiodd Dr Martina Fehler, 'Nodweddu derbynyddion olrhain amine yn y system gardiofasgwlaidd llygod mawr', yn 2008.
- Graddiodd Dr Peter Penson, 'isdeipiau b-Adrenoceptor a llwybrau trawssefydlu sy'n ymwneud â chyflyru myocardaidd cyn ac ar ôl cyflyru', yn 2009.
- Graddiodd Dr Rhys Evans, 'Modelau llid llwybrau anadlu cronig a ysgogwyd gan antigen dro ar ôl tro: swyddogaeth llwybrau anadlu a sensitifrwydd i asiantau gwrthlidiol', yn 2010.
- Graddiodd Dr Dawn Turner, 'Mecanweithiau gweithredu cyfansoddion sy'n rhoi ocsid nitrig mewn modelau o asthma', yn 2010.
- Graddiodd Dr Gaudencio Natividad, 'Unigedd a chymeriad cemegol a ffarmacolegol o antagonists derbynyddion aminau posibl o ffynonellau planhigion', yn 2011.
- Graddiodd Dr Alex Henson, 'Ymchwilio i rôl adenosine yn nhwf celloedd canser y fron dynol', yn 2011.
- Graddiodd Dr Martha Hvoslef-Eide, 'Nodweddu modelau llygoden mwtaniad APP trawsgenig o batholeg amyloid i'w defnyddio mewn imiwnotherapi cyn-glinigol', yn 2013.
- Graddiodd Dr Alex Lowe, 'Rôl heintiau firaol a bacteriol mewn gwaethygu asthma a gwrthsefyll corticosteroid', yn 2013.
- Graddiodd Dr Ceri Davies, 'In vivo examination of viral exacerbations of airways inflammation, function, mucus hypersecretion and mucociliary clearance', 2014.
- Graddiodd Dr Zakky Cholisoh, 'Mecanweithiau ymwrthedd i weithredoedd steroid yn y llwybrau anadlu', 2014
- Graddiodd Dr Charles Evans, 'Datblygu a nodweddu gwrthgorff protein rhagflaenydd gwrth-amyloid yn vivo fel therapi posibl ar gyfer clefyd Alzheimer', yn 2017.
- Graddiodd Dr Shayda Maleki-Toyserkani, 'Ymateb Eicosanoid i haint mewn sepsis', 2019.
- Graddiodd Dr Adam Brelsford, 'Iselder a dementia: Effaith patholeg ac ymyriadau therapiwtig Aβ ar brosesau affeithiol a gwybyddol mewn llygod', yn 2020.
- Graddiodd Dr Thomas Freeman, 'Elucidating rôl protein rhagflaenydd amyloid yn y cof arferol', yn 2020.
- Graddiodd Dr Jawza Almutairi, 'Deall sut mae oedran a rhywedd yn dylanwadu ar ddatblygiad clefyd Alzheimer', yn 2022.
Contact Details
+44 29208 75803
Adeilad Redwood , Ystafell 2.57B, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
Themâu ymchwil
Arbenigeddau
- Clefyd niwroddirywiol
- Niwrowyddoniaeth
- Ffarmacoleg a gwyddorau fferyllol
- Niwropharmacology
- Menopos