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Dr Sarah Langley
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Sarah Langley
Darlithydd
Niwrowyddoniaeth
Trosolwg
Rwy'n fiolegydd cyfrifiadurol profiadol y mae ei ymchwil yn canolbwyntio ar ddadansoddi data omics ar raddfa fawr i ymchwilio i rôl mynegiant RNA, prosesu RNA ac omics integreiddiol o fewn iechyd a chlefydau. Mae fy ngwaith yn eistedd o fewn meysydd bioleg gyfrifiadurol, bioleg foleciwlaidd a gwyddor data, gan gymhwyso dulliau meintiol i fynd i'r afael â chwestiynau biolegol a chlinigol perthnasol. O fewn y prif ffocws hwn o fy ngwaith, effaith ehangach fy ymchwil yw ymchwilio i rôl prosesu RNA ac RNA mewn clefydau ac mae ffocws fy addysgu ar y sgiliau a'r offer rydw i'n eu defnyddio i gynnal fy ymchwil (ystadegau, rhaglennu cyfrifiadurol, dadansoddiadau omics trwybwn uchel).
Er mwyn ymchwilio i fecanweithiau clefydau a phrosesau moleciwlaidd wedi'u camreoleiddio, rydym yn defnyddio setiau data omics ar raddfa fawr - yn bennaf dilyniannu RNA, dilyniannu DNA a proteomeg sbectrometreg màs - ynghyd â thechnegau dadansoddol blaengar. Trwy integreiddio'r gwahanol setiau data omics hyn mewn dull lefel systemau, rydym yn anelu at holi'r rôl y mae prosesau moleciwlaidd yn ei chwarae yn natblygiad a dilyniant clefyd.
Rydym hefyd yn datblygu methodolegau cyfrifiadurol a phiblinellau ar gyfer egluro mewnwelediad i setiau data biolegol mawr. Mae dewis y methodolegau hyn ar gyfer datblygu yn cael ei bennu gan y cwestiynau biolegol o ddiddordeb a'n gallu presennol i'w hateb. Mae hyn yn cynnwys cyfuniad o ystadegau, rhaglennu, dysgu peiriannau a defnyddio adnoddau cyfrifiadurol perfformiad uchel.
Cyhoeddiad
2026
- Utami, K. H. et al., 2026. Convergent and divergent molecular pathways in FMR1-, TSC2- and FMR1/TSC2 knockout neurons. Molecular Neurobiology 63 883. (10.1007/s12035-026-06166-3)
- Utami, K. H. et al., 2026. TSC2 GAP domain V1646Cfs*7 variant alters protein stability and interaction networks in tuberous sclerosis complex. Neurology Genetics 12 (2) e200351. (10.1212/nxg.0000000000200351)
- Bardile, C. F. et al., 2026. Alterations in both caliber and myelination of callosal axons elicited by ubiquitous genetic ablation of c-Jun amino-terminal kinase 3 (JNK3). Journal of Neurochemistry 170 (1) e70356. (10.1111/jnc.70356)
2025
- Wang, W. et al., 2025. Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues. Cell Genomics 5 (9) 100951. (10.1016/j.xgen.2025.100951)
- Wazny, V. K. et al., 2025. Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice. Nature Communications 16 6302. (10.1038/s41467-025-61614-3)
- Lai, K. O. et al., 2025. Age-dependent regulation of hippocampal inflammation by the mitochondrial translocator protein in mice. Aging Cell 24 (6) e70039. (10.1111/acel.70039)
- Leu, C. et al., 2025. Genome-wide association meta-analyses of drug-resistant epilepsy. EBioMedicine 115 105675. (10.1016/j.ebiom.2025.105675)
- Yadav, M. et al., 2025. PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites. Nucleic Acids Research 53 (8) gkaf347. (10.1093/nar/gkaf347)
2023
- Utami, K. H. et al., 2023. Dysregulated COMT expression in fragile X syndrome. NeuroMolecular Medicine 25 (4), pp.644-649. (10.1007/s12017-023-08754-1)
- Zalivina, I. et al., 2023. Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling. Journal of Molecular and Cellular Cardiology Plus 6 100056. (10.1016/j.jmccpl.2023.100056)
- Tano, V. et al., 2023. Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease. EBioMedicine 94 104720. (10.1016/j.ebiom.2023.104720)
- Fairley, L. H. et al., 2023. Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease. Proceedings of the National Academy of Sciences 120 (8) e2209177120. (10.1073/pnas.2209177120)
2022
- Tham, N. and Langley, S. R. 2022. Evaluating the robustness of connectivity methods to noise for in silico drug repurposing studies. Frontiers in Systems Biology 2 1050730. (10.3389/fsysb.2022.1050730)
- Ziaei, A. et al., 2022. Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult. Brain Pathology 32 (5) e13064. (10.1111/bpa.13064)
- Bao, X. et al., 2022. Molecular subgroups of intrahepatic cholangiocarcinoma discovered by single-cell RNA sequencing–assisted multiomics analysis. Cancer Immunology Research 10 (7), pp.811–828. (10.1158/2326-6066.CIR-21-1101)
- Chothani, S. P. et al., 2022. A high-resolution map of human RNA translation. Molecular Cell 82 (15), pp.2885-2899. (10.1016/j.molcel.2022.06.023)
2021
- Basnakova, A. et al., 2021. The habenula clock influences response to a stressor. Neurobiology of Stress 15 100403. (10.1016/j.ynstr.2021.100403)
2020
- Trott, J. et al., 2020. Mitchell-Riley syndrome iPSC exhibit reduced pancreatic endoderm differentiation due to an RFX6 mutation. Development 147 (21)(10.1242/dev.194878)
2019
- Zhang, J. et al., 2019. Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids. null (10.1101/850586)
- Laaniste, L. et al., 2019. Integrated systems-genetic analyses reveal a network target for delaying glioma progression.. Annals of Clinical and Translational Neurology 6 (9), pp.1616-1638. (10.1002/acn3.50850)
- Chothani, S. et al., 2019. Widespread translational control of fibrosis in the human heart by RNA-binding proteins.. Circulation 140 (11), pp.937-951. (10.1161/CIRCULATIONAHA.119.039596)
- Bardile, C. F. et al., 2019. Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America 116 (19), pp.9622-9627. (10.1073/pnas.1818042116)
- Tan, A. L. M. et al., 2019. Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore.. The Journal of Clinical Endocrinology & Metabolism 104 (2), pp.465-486. (10.1210/jc.2018-00309)
- Ooi, J. et al., 2019. Unbiased profiling of Isogenic Huntington Disease hPSC-Derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects. Cell Reports 26 (9), pp.2494-2508. (10.1016/j.celrep.2019.02.008)
2018
- Barwari, T. et al., 2018. Inhibition of profibrotic microRNA-21 affects platelets and their releasate.. JCI Insight 3 (21) e123335. (10.1172/jci.insight.123335)
- Chothani, S. et al., 2018. Translational control of cardiac fibrosis. [Online].bioRXiv. (10.1101/451666)Available at: https://doi.org/10.1101/451666.
- May, P. et al., 2018. Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study.. The Lancet. Neurology 17 (8), pp.699-708. (10.1016/s1474-4422(18)30215-1)
- McCormack, M. et al., 2018. Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.. Neurology 90 (4), pp.e332-e341. (10.1212/WNL.0000000000004853)
2017
- Berghuis, B. et al., 2017. Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy.. Epilepsia 58 (7), pp.1227-1233. (10.1111/epi.13777)
- Langley, S. R. et al. 2017. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.. Journal of Clinical Investigation 127 (4), pp.1546–1560. (10.1172/JCI86924)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome Bisulfite sequencing data identifies disease-associated changes in DNA Methylation.. Genetics 205 (4), pp.1443–1458. (10.1534/genetics.116.195008)
- Kumar Srivastava, P. et al., 2017. Genome-wide analysis of differential RNA editing in epilepsy.. Genome Research 27 (3), pp.440-450. (10.1101/gr.210740.116)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome bisulphite sequencing data identifies disease-associated changes in DNA methylation. null (10.1101/041715)
2016
- Delahaye-Duriez, A. et al., 2016. Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.. Genome Biology 17 245. (10.1186/s13059-016-1097-7)
- Gomes, R. S. et al., 2016. "Young at heart": regenerative potential linked to immature cardiac phenotypes.. Journal of Molecular and Cellular Cardiology 92 , pp.105-108. (10.1016/j.yjmcc.2016.01.026)
- Johnson, M. R. et al., 2016. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.. Nature Neuroscience 19 , pp.223-232. (10.1038/nn.4205)
- Kaudewitz, D. et al., 2016. Association of MicroRNAs and YRNAs with platelet function.. Circulation Research 118 (3), pp.420-432. (10.1161/CIRCRESAHA.114.305663)
- Zampetaki, A. et al., 2016. Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes.. Diabetes 65 (1), pp.216-227. (10.2337/db15-0389)
2015
- Langley, S. R. and Mayr, M. 2015. Comparative analysis of statistical methods used for detecting differential expression in label-free mass spectrometry proteomics.. Journal of Proteomics 129 , pp.83-92. (10.1016/j.jprot.2015.07.012)
- Roncon, P. et al., 2015. MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.. Scientific Reports 5 14143. (10.1038/srep14143)
- Johnson, M. R. et al., 2015. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.. Nature Communications 6 6031. (10.1038/ncomms7031)
2014
- Johnson, M. D. et al., 2014. Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.. Plos Genetics 10 (12) e1004813. (10.1371/journal.pgen.1004813)
- Cuello, F. et al., 2014. Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis.. Molecular & cellular proteomics : MCP 13 (10), pp.2545-2557. (10.1074/mcp.M114.039446)
- Zampetaki, A. et al., 2014. Role of miR-195 in aortic aneurysmal disease.. Circulation Research 115 (10), pp.857-866. (10.1161/circresaha.115.304361)
- Goedeke, L. et al., 2014. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice.. EMBO Molecular Medicine 6 (9), pp.1133-1141. (10.15252/emmm.201404046)
- Stegemann, C. et al., 2014. Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study.. Circulation Research 129 (18), pp.1821-1831. (10.1161/circulationaha.113.002500)
- Beyer, C. et al., 2014. Signature of circulating microRNAs in osteoarthritis.. Annals of the Rheumatic Diseases 74 (3)(10.1136/annrheumdis-2013-204698)
2013
- Abonnenc, M. et al., 2013. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.. Circulation Research 113 (10), pp.1138-1147. (10.1161/circresaha.113.302400)
- Langley, S. R. et al. 2013. Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.. Cardiovascular Research 97 (4), pp.653-665. (10.1093/cvr/cvs329)
- Langley, S. R. et al. 2013. Proteomics: from single molecules to biological pathways.. Cardiovascular Research 97 (4), pp.612-622. (10.1093/cvr/cvs346)
- Stegemann, C. et al., 2013. Proteomic identification of matrix metalloproteinase substrates in the human vasculature.. Circulation. Cardiovascular genetics 6 (1), pp.106-117. (10.1161/circgenetics.112.964452)
- Yin, X. et al., 2013. Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.. Journal of Molecular and Cellular Cardiology 55 , pp.27-30. (10.1016/j.yjmcc.2012.12.014)
- Willeit, P. et al., 2013. Circulating microRNAs as novel biomarkers for platelet activation.. Circulation Research 112 (4), pp.595-600. (10.1161/circresaha.111.300539)
2011
- Lin, B. et al., 2011. Determining signalling nodes for apoptosis by a genetic high-throughput screen. Plos One 6 (9) e25023. (10.1371/journal.pone.0025023)
- Bottolo, L. et al., 2011. ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration.. Bioinformatics 27 (4), pp.587-588. (10.1093/bioinformatics/btq684)
2010
- Heinig, M. et al., 2010. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.. Nature 467 , pp.460-464. (10.1038/nature09386)
- Petretto, E. et al., 2010. New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.. PLoS Computational Biology (10.1371/journal.pcbi.1000737)
2008
- Stylianou, I. M. et al., 2008. Differences in DBA/1J and DBA/2J reveal lipid QTL genes.. Journal of Lipid Research 49 (11), pp.2402-2413. (10.1194/jlr.M800244-JLR200)
Erthyglau
- Utami, K. H. et al., 2026. Convergent and divergent molecular pathways in FMR1-, TSC2- and FMR1/TSC2 knockout neurons. Molecular Neurobiology 63 883. (10.1007/s12035-026-06166-3)
- Utami, K. H. et al., 2026. TSC2 GAP domain V1646Cfs*7 variant alters protein stability and interaction networks in tuberous sclerosis complex. Neurology Genetics 12 (2) e200351. (10.1212/nxg.0000000000200351)
- Bardile, C. F. et al., 2026. Alterations in both caliber and myelination of callosal axons elicited by ubiquitous genetic ablation of c-Jun amino-terminal kinase 3 (JNK3). Journal of Neurochemistry 170 (1) e70356. (10.1111/jnc.70356)
- Wang, W. et al., 2025. Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues. Cell Genomics 5 (9) 100951. (10.1016/j.xgen.2025.100951)
- Wazny, V. K. et al., 2025. Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice. Nature Communications 16 6302. (10.1038/s41467-025-61614-3)
- Lai, K. O. et al., 2025. Age-dependent regulation of hippocampal inflammation by the mitochondrial translocator protein in mice. Aging Cell 24 (6) e70039. (10.1111/acel.70039)
- Leu, C. et al., 2025. Genome-wide association meta-analyses of drug-resistant epilepsy. EBioMedicine 115 105675. (10.1016/j.ebiom.2025.105675)
- Yadav, M. et al., 2025. PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites. Nucleic Acids Research 53 (8) gkaf347. (10.1093/nar/gkaf347)
- Utami, K. H. et al., 2023. Dysregulated COMT expression in fragile X syndrome. NeuroMolecular Medicine 25 (4), pp.644-649. (10.1007/s12017-023-08754-1)
- Zalivina, I. et al., 2023. Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling. Journal of Molecular and Cellular Cardiology Plus 6 100056. (10.1016/j.jmccpl.2023.100056)
- Tano, V. et al., 2023. Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease. EBioMedicine 94 104720. (10.1016/j.ebiom.2023.104720)
- Fairley, L. H. et al., 2023. Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease. Proceedings of the National Academy of Sciences 120 (8) e2209177120. (10.1073/pnas.2209177120)
- Tham, N. and Langley, S. R. 2022. Evaluating the robustness of connectivity methods to noise for in silico drug repurposing studies. Frontiers in Systems Biology 2 1050730. (10.3389/fsysb.2022.1050730)
- Ziaei, A. et al., 2022. Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult. Brain Pathology 32 (5) e13064. (10.1111/bpa.13064)
- Bao, X. et al., 2022. Molecular subgroups of intrahepatic cholangiocarcinoma discovered by single-cell RNA sequencing–assisted multiomics analysis. Cancer Immunology Research 10 (7), pp.811–828. (10.1158/2326-6066.CIR-21-1101)
- Chothani, S. P. et al., 2022. A high-resolution map of human RNA translation. Molecular Cell 82 (15), pp.2885-2899. (10.1016/j.molcel.2022.06.023)
- Basnakova, A. et al., 2021. The habenula clock influences response to a stressor. Neurobiology of Stress 15 100403. (10.1016/j.ynstr.2021.100403)
- Trott, J. et al., 2020. Mitchell-Riley syndrome iPSC exhibit reduced pancreatic endoderm differentiation due to an RFX6 mutation. Development 147 (21)(10.1242/dev.194878)
- Zhang, J. et al., 2019. Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids. null (10.1101/850586)
- Laaniste, L. et al., 2019. Integrated systems-genetic analyses reveal a network target for delaying glioma progression.. Annals of Clinical and Translational Neurology 6 (9), pp.1616-1638. (10.1002/acn3.50850)
- Chothani, S. et al., 2019. Widespread translational control of fibrosis in the human heart by RNA-binding proteins.. Circulation 140 (11), pp.937-951. (10.1161/CIRCULATIONAHA.119.039596)
- Bardile, C. F. et al., 2019. Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease. Proceedings of the National Academy of Sciences of the United States of America 116 (19), pp.9622-9627. (10.1073/pnas.1818042116)
- Tan, A. L. M. et al., 2019. Ethnicity-specific skeletal muscle transcriptional signatures and their relevance to insulin resistance in Singapore.. The Journal of Clinical Endocrinology & Metabolism 104 (2), pp.465-486. (10.1210/jc.2018-00309)
- Ooi, J. et al., 2019. Unbiased profiling of Isogenic Huntington Disease hPSC-Derived CNS and peripheral cells reveals strong cell-type specificity of CAG length effects. Cell Reports 26 (9), pp.2494-2508. (10.1016/j.celrep.2019.02.008)
- Barwari, T. et al., 2018. Inhibition of profibrotic microRNA-21 affects platelets and their releasate.. JCI Insight 3 (21) e123335. (10.1172/jci.insight.123335)
- May, P. et al., 2018. Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study.. The Lancet. Neurology 17 (8), pp.699-708. (10.1016/s1474-4422(18)30215-1)
- McCormack, M. et al., 2018. Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.. Neurology 90 (4), pp.e332-e341. (10.1212/WNL.0000000000004853)
- Berghuis, B. et al., 2017. Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy.. Epilepsia 58 (7), pp.1227-1233. (10.1111/epi.13777)
- Langley, S. R. et al. 2017. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.. Journal of Clinical Investigation 127 (4), pp.1546–1560. (10.1172/JCI86924)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome Bisulfite sequencing data identifies disease-associated changes in DNA Methylation.. Genetics 205 (4), pp.1443–1458. (10.1534/genetics.116.195008)
- Kumar Srivastava, P. et al., 2017. Genome-wide analysis of differential RNA editing in epilepsy.. Genome Research 27 (3), pp.440-450. (10.1101/gr.210740.116)
- Rackham, O. J. L. et al., 2017. A Bayesian approach for analysis of whole-genome bisulphite sequencing data identifies disease-associated changes in DNA methylation. null (10.1101/041715)
- Delahaye-Duriez, A. et al., 2016. Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery.. Genome Biology 17 245. (10.1186/s13059-016-1097-7)
- Gomes, R. S. et al., 2016. "Young at heart": regenerative potential linked to immature cardiac phenotypes.. Journal of Molecular and Cellular Cardiology 92 , pp.105-108. (10.1016/j.yjmcc.2016.01.026)
- Johnson, M. R. et al., 2016. Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.. Nature Neuroscience 19 , pp.223-232. (10.1038/nn.4205)
- Kaudewitz, D. et al., 2016. Association of MicroRNAs and YRNAs with platelet function.. Circulation Research 118 (3), pp.420-432. (10.1161/CIRCRESAHA.114.305663)
- Zampetaki, A. et al., 2016. Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes.. Diabetes 65 (1), pp.216-227. (10.2337/db15-0389)
- Langley, S. R. and Mayr, M. 2015. Comparative analysis of statistical methods used for detecting differential expression in label-free mass spectrometry proteomics.. Journal of Proteomics 129 , pp.83-92. (10.1016/j.jprot.2015.07.012)
- Roncon, P. et al., 2015. MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.. Scientific Reports 5 14143. (10.1038/srep14143)
- Johnson, M. R. et al., 2015. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.. Nature Communications 6 6031. (10.1038/ncomms7031)
- Johnson, M. D. et al., 2014. Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.. Plos Genetics 10 (12) e1004813. (10.1371/journal.pgen.1004813)
- Cuello, F. et al., 2014. Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis.. Molecular & cellular proteomics : MCP 13 (10), pp.2545-2557. (10.1074/mcp.M114.039446)
- Zampetaki, A. et al., 2014. Role of miR-195 in aortic aneurysmal disease.. Circulation Research 115 (10), pp.857-866. (10.1161/circresaha.115.304361)
- Goedeke, L. et al., 2014. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice.. EMBO Molecular Medicine 6 (9), pp.1133-1141. (10.15252/emmm.201404046)
- Stegemann, C. et al., 2014. Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study.. Circulation Research 129 (18), pp.1821-1831. (10.1161/circulationaha.113.002500)
- Beyer, C. et al., 2014. Signature of circulating microRNAs in osteoarthritis.. Annals of the Rheumatic Diseases 74 (3)(10.1136/annrheumdis-2013-204698)
- Abonnenc, M. et al., 2013. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.. Circulation Research 113 (10), pp.1138-1147. (10.1161/circresaha.113.302400)
- Langley, S. R. et al. 2013. Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.. Cardiovascular Research 97 (4), pp.653-665. (10.1093/cvr/cvs329)
- Langley, S. R. et al. 2013. Proteomics: from single molecules to biological pathways.. Cardiovascular Research 97 (4), pp.612-622. (10.1093/cvr/cvs346)
- Stegemann, C. et al., 2013. Proteomic identification of matrix metalloproteinase substrates in the human vasculature.. Circulation. Cardiovascular genetics 6 (1), pp.106-117. (10.1161/circgenetics.112.964452)
- Yin, X. et al., 2013. Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.. Journal of Molecular and Cellular Cardiology 55 , pp.27-30. (10.1016/j.yjmcc.2012.12.014)
- Willeit, P. et al., 2013. Circulating microRNAs as novel biomarkers for platelet activation.. Circulation Research 112 (4), pp.595-600. (10.1161/circresaha.111.300539)
- Lin, B. et al., 2011. Determining signalling nodes for apoptosis by a genetic high-throughput screen. Plos One 6 (9) e25023. (10.1371/journal.pone.0025023)
- Bottolo, L. et al., 2011. ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration.. Bioinformatics 27 (4), pp.587-588. (10.1093/bioinformatics/btq684)
- Heinig, M. et al., 2010. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.. Nature 467 , pp.460-464. (10.1038/nature09386)
- Petretto, E. et al., 2010. New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.. PLoS Computational Biology (10.1371/journal.pcbi.1000737)
- Stylianou, I. M. et al., 2008. Differences in DBA/1J and DBA/2J reveal lipid QTL genes.. Journal of Lipid Research 49 (11), pp.2402-2413. (10.1194/jlr.M800244-JLR200)
Gwefannau
- Chothani, S. et al., 2018. Translational control of cardiac fibrosis. [Online].bioRXiv. (10.1101/451666)Available at: https://doi.org/10.1101/451666.
Ymchwil
Mae technolegau genomig ac ôl-genomig wedi arwain at setiau data amlochrog ar raddfa fawr sy'n ddibynadwy ac yn syml i'w cynhyrchu. Mae'r her gydag argaeledd symiau mor fawr o ddata bellach yn gorwedd gyda'r dadansoddiad a'r dehongli i lywio ar brosesau biolegol a chlefydau a deillio rhagdybiaethau sy'n cael eu gyrru gan ddata. Er mwyn mynd i'r afael â'r her hon, mae fy ngwaith yn canolbwyntio ar integreiddio a dadansoddi data 'omics ar raddfa fawr i ymchwilio i brosesau moleciwlaidd sy'n gysylltiedig ag iechyd a'r prosesau dysreoleiddiedig hynny sy'n sail i glefyd.
Mae fy ymchwil yn defnyddio data bioleg gyfrifiadurol a omics ar raddfa fawr i ddeall sut mae mynegiant RNA a phrosesu RNA yn cyfrannu at iechyd, heneiddio a chlefyd niwroddirywiol. Trwy integreiddio data trawsgrifio â data genomig, epigenetig a proteomig, rwy'n anelu at nodi mecanweithiau moleuclar sy'n cynnal swyddogaeth yr ymennydd iechyd ac yn gyrru dilyniant clefyd niwroddirywiol.
Cyllid cyfredol a blaenorol gan: Cymdeithas Clefyd Niwronau Modur, y Gymdeithas Frenhinol, Alzheimer's Research UK, yr Academi Brydeinig, Llywodraeth Cymru, Weinyddiaeth Addysg Sinapore, Cymdeithas Genedlaethol Sglerosis Ymledol
Addysgu
Rwy'n cyfrannu at addysgu ar draws y rhaglenni ymchwil israddedig, ôl-raddedig a addysgir ôl-raddedig o fewn yr Ysgol Biowyddorau ac ar draws y Brifysgol ehangach.
Enghreifftiau o fodiwlau rwy'n eu dysgu ar:
BI1001 - Sgiliau ar gyfer Gwyddoniaeth
BI3252 - Chwyldro Omics
BIT002 - Technegau Ymchwil yn y Biowyddorau
BIT106 - Biowybodeg
Rwyf hefyd yn goruchwylio prosiectau ymchwil fel rhan o'r Prosiectau Blwyddyn Olaf, Meistr Integredig ac MScs Bioleg / Biowybodeg Data Mawr
Rwy'n Gymrawd yr Acadamy Addysg Uwch (2025).
Bywgraffiad
Addysg
- PhD, Geneteg Ystadegol a Biowybodeg, Coleg Imperial Llundain, 2008 - 2012
- MSc, Biowybodeg a Bioleg Systemau Damcaniaethol, Coleg Imperial Llundain, 2007 - 2008
- BA, Ffiseg a Gwyddorau Mathemategol, Coleg Colby, 2003 - 2007
Swyddi blaenorol
- Athro Cynorthwyol Bioleg Gyfrifiadurol Nanyang, Ysgol Meddygaeth Chian Lee Kong, Prifysgol Dechnolegol Nanyang Singapore, 2019 - 2023
- Uwch Gymrawd Ymchwil, Ysgol Feddygol Duke-NUS Singapore, 2015 - 2018
- Cydymaith Ymchwil Ôl-ddoethurol, Coleg Imperial Llundain, 2014 - 2015
- Cydymaith Ymchwil Ôl-ddoethurol, Coleg y Brenin Llundain, 2012 - 2014
Aelodaethau proffesiynol
Rwy'n Gymrawd yr Acadamy Addysg Uwch (2025).
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PGR ym meysydd
- Bioleg Gyfrifiadurol
- Prosesu RNA
- Dysregulation trawsgrifio ac ôl-drawsgrifio mewn clefyd
Goruchwyliaeth gyfredol
Jamie McDonald
Sophie Shaw