Dr Samantha Loveless
(hi/ei)
BSc (Cardiff), PhD (Cardiff)
Rheolwr Labordy, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
Trosolwyg
Ar hyn o bryd rwy'n cael fy nghyflogi fel y Rheolwr Bioystorfa a Labordy ar gyfer y Lab Niwroleg Academaidd sydd wedi'i leoli ar gampws Prifysgol Caerdydd.
Mae fy rôl yn cynnwys rheoli Banc Meinwe Niwrowyddoniaeth Cymru (WNRTB); cymeradwyo, cydsynio, casglu, storio a dyrannu samplau cleifion niwroleg ar gyfer y biobanc, yn ogystal â phrosiectau niwroleg penodol eraill (ERYRI, Epilepsi-Bio) a breichiau biofancio treialon clinigol Sglerosis Ymledol (MS) (megis Octopus a DELIVER-MS), cydlynu casglu a dosbarthu samplau ar draws sawl safle cenedlaethol a rhyngwladol.
Rwy'n rheoli'r labordy a'r cyfleusterau yn ogystal â thîm o dechnegwyr ymchwil ar gyfer y grŵp ymchwil MS ac Uned BRAIN, gan gefnogi ymchwil i ystod eang o anhwylderau gan gynnwys MS, NMO, epilepsi, MND, glioblastoma, IIH.
Mae fy ymchwil yn canolbwyntio'n bennaf ar fiofarcwyr hylif mewn MS gyda sawl papur cydweithredol wedi'u cyhoeddi hyd yma.
Cyhoeddiad
2024
- Gelissen, L. M. et al. 2024. Subcutaneous administration of natalizumab can lead to lower drug concentrations compared to intravenous administration. Multiple Sclerosis and Related Disorders 90, article number: 105796. (10.1016/j.msard.2024.105796)
- Kreft, K. L. et al. 2024. Relevance of multiple sclerosis severity genotype in predicting disease course: A real-world cohort. Annals of Neurology 95(3), pp. 459-470. (10.1002/ana.26831)
- Kodosaki, E. et al. 2024. Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes. Journal of Neuroinflammation 21(1), article number: 52. (10.1186/s12974-024-03036-4)
2023
- Zaloum, S. et al. 2023. Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination. Multiple Sclerosis Journal 29(8), pp. 979-989. (10.1177/13524585231185247)
2022
- Beesley, R. et al. 2022. Multiple sclerosis and COVID-19: Assessing risk perception, patient behaviours and access to disease-modifying therapies. Multiple Sclerosis and Related Disorders 68, article number: 104121. (10.1016/j.msard.2022.104121)
- Tallantyre, E. et al. 2022. COVID-19 vaccine response in people with multiple sclerosis. Annals of Neurology 91(1), pp. 89-100. (10.1002/ana.26251)
2021
- Hrastelj, J. et al. 2021. CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis. Brain Communications (10.1093/braincomms/fcab155)
- Hares, K. et al. 2021. KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis. Journal of Neurology 268, pp. 2175-2184. (10.1007/s00415-020-10373-w)
2020
- Zelek, W. M. et al. 2020. Cerebrospinal fluid complement system biomarkers in demyelinating disease. Multiple Sclerosis 26(14), pp. 1929-1937. (10.1177/1352458519887905)
- Naughton, M. et al. 2020. CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis. Journal of Neuroinflammation 17(1), article number: 349. (10.1186/s12974-020-02025-7)
- Anderson, V. et al. 2020. Serum neurofilament-light concentration and real-world outcome in MS. Journal of the Neurological Sciences 417, article number: 117079. (10.1016/j.jns.2020.117079)
- Saxena, G. et al. 2020. Detecting and predicting neutralization of alemtuzumab responses in multiple sclerosis. Neurology, Neuroimmunology and Neuroinflammation 7(4), article number: e767. (10.1212/NXI.0000000000000767)
- Yeo, T. et al. 2020. A blood-based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application. Scientific Reports 10, article number: 12381. (10.1038/s41598-020-69119-3)
2019
- Castle, D., Wynford-Thomas, R., Loveless, S., Bentley, E., Howell, O. W. and Tallantyre, E. C. 2019. Using biomarkers to predict clinical outcomes in multiple sclerosis. Practical Neurology 19(4), pp. 342-349. (10.1136/practneurol-2018-002000)
- Zelek, W. M. et al. 2019. Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59. Multiple Sclerosis 25(4), pp. 523-531. (10.1177/1352458518758927)
2018
- Muller, I. et al. 2018. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years.. Thyroid 28(12), pp. 1682-1693. (10.1089/thy.2018.0232)
- Kopczynska, M. et al. 2018. Complement system biomarkers in epilepsy. Seizure - European Journal of Epilepsy 60, pp. 1-7. (10.1016/j.seizure.2018.05.016)
- Loveless, S. et al. 2018. Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis. Brain Pathology 28(4), pp. 507-520. (10.1111/bpa.12546)
2017
- Welton, J. L., Loveless, S., Stone, T., Von Ruhland, C., Robertson, N. and Clayton, A. 2017. Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis. Journal of Extracellular Vesicles 6(1), article number: 1369805. (10.1080/20013078.2017.1369805)
- Hakobyan, S., Luppe, S., Evans, D. R. S., Harding, K., Loveless, S., Robertson, N. P. and Morgan, B. P. 2017. Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal 23(7), pp. 946-955., article number: 135245851666900. (10.1177/1352458516669002)
2016
- Watkins, L. M. et al. 2016. Complement is activated in progressive multiple sclerosis cortical grey matter lesions. Journal of Neuroinflammation 13, article number: 161. (10.1186/s12974-016-0611-x)
2015
- Willis, M., Harding, K., Wardle, M., Pickersgill, T. P., Tomassini, V., Loveless, S. and Robertson, N. 2015. Site-specific clinical disease onset in multiple sclerosis. European Journal of Neurology 22(4), pp. 732-735. (10.1111/ene.12564)
2014
- Ingram, G. et al. 2014. Complement activation in MS: An immunohistochemical analysis. Journal of Neurology, Neurosurgery & Psychiatry 85(10), pp. e4.13. (10.1136/jnnp-2014-309236.11)
- Ingram, G. et al. 2014. Complement activation in multiple sclerosis plaques: an immunohistochemical analysis. Acta Neuropathologica Communications 2, article number: 53. (10.1186/2051-5960-2-53)
- Stewart, J. P. et al. 2014. Seroprevalence of molluscum contagiosum virus in German and UK populations. PLoS ONE 9(2), article number: e88734. (10.1371/journal.pone.0088734)
2012
- Ingram, G. et al. 2012. Systemic complement profiling in multiple sclerosis as a biomarker of disease state. Multiple Sclerosis Journal 18(10), pp. 1401-1411. (10.1177/1352458512438238)
2011
- Ingram, G., Hakobyan, S., Loveless, S., Robertson, N. and Morgan, B. P. 2011. Complement regulator factor H in multiple sclerosis. Journal of Cellular Biochemistry 112(10), pp. 2653-2654. (10.1002/jcb.23204)
2010
- Ingram, G. et al. 2010. Complement regulator factor H as a serum biomarker of multiple sclerosis disease state. Brain 133(6), pp. 1602-1611. (10.1093/brain/awq085)
- Ingram, G., Bugert, J. J., Loveless, S. and Robertson, N. 2010. Anti-EBNA-1 IgG is not a reliable marker of multiple sclerosis clinical disease activity. European Journal of Neurology 17(11), pp. 1386-1389. (10.1111/j.1468-1331.2010.03083.x)
Articles
- Gelissen, L. M. et al. 2024. Subcutaneous administration of natalizumab can lead to lower drug concentrations compared to intravenous administration. Multiple Sclerosis and Related Disorders 90, article number: 105796. (10.1016/j.msard.2024.105796)
- Kreft, K. L. et al. 2024. Relevance of multiple sclerosis severity genotype in predicting disease course: A real-world cohort. Annals of Neurology 95(3), pp. 459-470. (10.1002/ana.26831)
- Kodosaki, E. et al. 2024. Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes. Journal of Neuroinflammation 21(1), article number: 52. (10.1186/s12974-024-03036-4)
- Zaloum, S. et al. 2023. Risk of COVID-19 in people with multiple sclerosis who are seronegative following vaccination. Multiple Sclerosis Journal 29(8), pp. 979-989. (10.1177/13524585231185247)
- Beesley, R. et al. 2022. Multiple sclerosis and COVID-19: Assessing risk perception, patient behaviours and access to disease-modifying therapies. Multiple Sclerosis and Related Disorders 68, article number: 104121. (10.1016/j.msard.2022.104121)
- Tallantyre, E. et al. 2022. COVID-19 vaccine response in people with multiple sclerosis. Annals of Neurology 91(1), pp. 89-100. (10.1002/ana.26251)
- Hrastelj, J. et al. 2021. CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis. Brain Communications (10.1093/braincomms/fcab155)
- Hares, K. et al. 2021. KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis. Journal of Neurology 268, pp. 2175-2184. (10.1007/s00415-020-10373-w)
- Zelek, W. M. et al. 2020. Cerebrospinal fluid complement system biomarkers in demyelinating disease. Multiple Sclerosis 26(14), pp. 1929-1937. (10.1177/1352458519887905)
- Naughton, M. et al. 2020. CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis. Journal of Neuroinflammation 17(1), article number: 349. (10.1186/s12974-020-02025-7)
- Anderson, V. et al. 2020. Serum neurofilament-light concentration and real-world outcome in MS. Journal of the Neurological Sciences 417, article number: 117079. (10.1016/j.jns.2020.117079)
- Saxena, G. et al. 2020. Detecting and predicting neutralization of alemtuzumab responses in multiple sclerosis. Neurology, Neuroimmunology and Neuroinflammation 7(4), article number: e767. (10.1212/NXI.0000000000000767)
- Yeo, T. et al. 2020. A blood-based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application. Scientific Reports 10, article number: 12381. (10.1038/s41598-020-69119-3)
- Castle, D., Wynford-Thomas, R., Loveless, S., Bentley, E., Howell, O. W. and Tallantyre, E. C. 2019. Using biomarkers to predict clinical outcomes in multiple sclerosis. Practical Neurology 19(4), pp. 342-349. (10.1136/practneurol-2018-002000)
- Zelek, W. M. et al. 2019. Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59. Multiple Sclerosis 25(4), pp. 523-531. (10.1177/1352458518758927)
- Muller, I. et al. 2018. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years.. Thyroid 28(12), pp. 1682-1693. (10.1089/thy.2018.0232)
- Kopczynska, M. et al. 2018. Complement system biomarkers in epilepsy. Seizure - European Journal of Epilepsy 60, pp. 1-7. (10.1016/j.seizure.2018.05.016)
- Loveless, S. et al. 2018. Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis. Brain Pathology 28(4), pp. 507-520. (10.1111/bpa.12546)
- Welton, J. L., Loveless, S., Stone, T., Von Ruhland, C., Robertson, N. and Clayton, A. 2017. Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis. Journal of Extracellular Vesicles 6(1), article number: 1369805. (10.1080/20013078.2017.1369805)
- Hakobyan, S., Luppe, S., Evans, D. R. S., Harding, K., Loveless, S., Robertson, N. P. and Morgan, B. P. 2017. Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal 23(7), pp. 946-955., article number: 135245851666900. (10.1177/1352458516669002)
- Watkins, L. M. et al. 2016. Complement is activated in progressive multiple sclerosis cortical grey matter lesions. Journal of Neuroinflammation 13, article number: 161. (10.1186/s12974-016-0611-x)
- Willis, M., Harding, K., Wardle, M., Pickersgill, T. P., Tomassini, V., Loveless, S. and Robertson, N. 2015. Site-specific clinical disease onset in multiple sclerosis. European Journal of Neurology 22(4), pp. 732-735. (10.1111/ene.12564)
- Ingram, G. et al. 2014. Complement activation in MS: An immunohistochemical analysis. Journal of Neurology, Neurosurgery & Psychiatry 85(10), pp. e4.13. (10.1136/jnnp-2014-309236.11)
- Ingram, G. et al. 2014. Complement activation in multiple sclerosis plaques: an immunohistochemical analysis. Acta Neuropathologica Communications 2, article number: 53. (10.1186/2051-5960-2-53)
- Stewart, J. P. et al. 2014. Seroprevalence of molluscum contagiosum virus in German and UK populations. PLoS ONE 9(2), article number: e88734. (10.1371/journal.pone.0088734)
- Ingram, G. et al. 2012. Systemic complement profiling in multiple sclerosis as a biomarker of disease state. Multiple Sclerosis Journal 18(10), pp. 1401-1411. (10.1177/1352458512438238)
- Ingram, G., Hakobyan, S., Loveless, S., Robertson, N. and Morgan, B. P. 2011. Complement regulator factor H in multiple sclerosis. Journal of Cellular Biochemistry 112(10), pp. 2653-2654. (10.1002/jcb.23204)
- Ingram, G. et al. 2010. Complement regulator factor H as a serum biomarker of multiple sclerosis disease state. Brain 133(6), pp. 1602-1611. (10.1093/brain/awq085)
- Ingram, G., Bugert, J. J., Loveless, S. and Robertson, N. 2010. Anti-EBNA-1 IgG is not a reliable marker of multiple sclerosis clinical disease activity. European Journal of Neurology 17(11), pp. 1386-1389. (10.1111/j.1468-1331.2010.03083.x)
Contact Details
LovelessS1@caerdydd.ac.uk
+44 29207 43454
Prif Adeilad yr Ysbyty, Llawr 4ydd Llawr, Coridor B-C, Ystafell 80G, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
+44 29207 43454
Prif Adeilad yr Ysbyty, Llawr 4ydd Llawr, Coridor B-C, Ystafell 80G, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN