Ewch i’r prif gynnwys
Tracey Martin

Dr Tracey Martin

(hi/ei)

Uwch Ddarlithydd mewn Bioleg Cell a Tumour, Cyfarwyddwr Ymchwil Ôl-raddedig

Yr Ysgol Meddygaeth

Email
MartinTA1@caerdydd.ac.uk
Telephone
+44 29206 87209
Campuses
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Llawr 1, Ystafell Swyddfa Ymchwil Ôl-raddedig, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Users
Ar gael fel goruchwyliwr ôl-raddedig

Trosolwyg

Ar ôl PhD mewn Bioleg Foleciwlaidd ym Mhrifysgol Caerdydd, dechreuais yrfa Ôl-ddoethurol yng Ngholeg Meddygaeth Prifysgol Cymru, gan ymchwilio i rôl Ffactor Twf Hepatocyte (HGF) ar endothelia. Arweiniodd hyn at y cyfle i archwilio HGF a'i wrthwynebydd NK4 mewn canser. Ers 1998, rwyf wedi bod yn ymwneud ag ymchwilio i rôl cyffyrdd tynn mewn canser (yn ystod metastasis) ac mewn endothelia (yn ystod angiogenesis). Mae fy niddordebau ymchwil yn cynnwys ymchwilio i sut y gellir modiwleiddio cyffyrdd tynn i reoli datgysylltiad a goresgyniad celloedd canser, ynghyd â diddordeb parhaus mewn ffactorau angiogenic a'u rôl mewn metastasis gyda diddordeb arbennig yn y mecanweithiau lle gall HGF reoli cynulliad cyffordd tynn a gweithredu mewn canser ac endothelia a rôl cyffyrdd tynn a metastasis ar draws rhwystr ymennydd y gwaed.

Rolau eraill:

  • Cyfarwyddwr Ymchwil Ôl-raddedig yr Ysgol Meddygaeth
  • Dirprwy Arweinydd ar gyfer Ymchwil Ôl-raddedig, Is-adran Canser a Geneteg
  • Cyfarwyddwr Rhaglenni Rhyngwladol Ysgolheigion y Gaeaf a'r Haf yr Ysgol Meddygaeth
  • Cadeirydd yr Is-bwyllgor Cydraddoldeb Canser a Geneteg, Amrywiaeth a Chynhwysiant
  • Hyrwyddwr Lles yr Ysgol Meddygaeth
  • Swyddog Llywodraethu Ymchwil Meinwe Dynol

Cyhoeddiad

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2003

2001

1999

Adrannau llyfrau

Cynadleddau

Erthyglau

Ymchwil

Cyffyrdd celloedd fel cyfryngwyr neu rwystrau i ledaenu celloedd a'r rheoleiddwyr ohono

  • Mae'r Cyffordd Dynn (TJ) yn rhanbarth lle mae pilen plasma celloedd cyfagos yn ffurfio cyfres o gysylltiadau sy'n ymddangos eu bod yn atal y gofod allgellog yn llwyr gan greu rhwystr rhynggellog a ffens trylediad intramembrane.
  • Mewn celloedd epithelaidd, mae'r TJ yn gweithredu mewn modd gludiog a gall atal datgysylltu celloedd tra bod TJs mewn celloedd endothelaidd yn gweithredu fel rhwystr lle gall moleciwlau a chelloedd llidiol basio.
  • Mae corff sylweddol o waith bellach yn bodoli ar TJ a'u rôl mewn nifer o glefydau.
  • Mae TJs wedi cael eu cydnabod fel chwaraewyr allweddol mewn metastasis canser. Awgrymodd astudiaethau cynnar fod cysylltiad rhwng lleihau proteinau TJ a gwahaniaethu tiwmorau a chynyddu tystiolaeth arbrofol wedi dod i'r amlwg i osod TJs yn y rheng flaen fel y strwythur y mae'n rhaid i gelloedd canser ei oresgyn er mwyn metastasize.
  • Mae rhyngweithio a threiddiad yr endotheliwm fasgwlaidd gan gelloedd canser datgysylltiol yn gam pwysig wrth ffurfio metastases canser.
  • Mae angen newidiadau mewn celloedd tiwmor ac endothelaidd ar gyfer twf a lledaeniad celloedd canser yn llwyddiannus a bod y newidiadau hyn ychydig yn debyg.
  • Mae newid mewn celloedd canser trwy uwchreoleiddio neu isreoleiddio proteinau TJ perthnasol yn arwain at golli cysylltiad celloedd-gell, atal cyswllt celloedd, gan arwain at dwf heb reolaeth, colli adlyniad i'r islawr a diraddio.
  • Rhaid i'r rhain fod yn golled gydamserol o gysylltiad cell-gell yn endotheliwm a modwleiddio proteinau TJ sy'n ymwneud â hwyluso hynt y celloedd canser trwy'r rhwystr hwn.
  • Rydym wedi dangos bod mynegiant gwahaniaethol o nifer o broteinau TJ trawsmembrane, yn enwedig Occludin, Claudin-5 a'r Nectin a'u bod yn cydberthyn ag aflonyddwch TJs mewn tiwmorau.
  • Mae modiwleiddio mynegiant o'r proteinau hyn yn arwain at newidiadau allweddol mewn swyddogaeth rhwystr gan arwain at ddilyniant canser a dilyniant metastasis.

Meysydd ymchwil

Triniaethau minimally ymledol:

  1. Technoleg therapiwtig lleiaf ymledol newydd

rhwystr ymennydd gwaed (BBB):

  1. Modulators o ddynameg BBB
  2. Cymhariaeth o wahanol gelloedd endothelaidd BBB a rôl HGF mewn metastasis ymennydd.

HAVcR-1:

  1. Swyddogaeth HAVcR-1 mewn canser y fron a'i reolaeth ar swyddogaeth rhwystr.
  2. HAVcR-1 fel modulator sylweddol o signalau HGF mewn metastasis canser y prostad trwy reoli TJs.

Occludin ac MARVELD3:

  1. Rheoli swyddogaeth TJ gan Occludin / MARVELD3 ac isofformau gwahanol mewn metastasis canser y fron a colorectal.

Arwyddion a rheolaeth ar TJs:

  1. Sut mae SIPA-1 wedi'i integreiddio i lwybr signalau HGF swyddogaeth TJ mewn canser y fron.
  2. Archwilio aelodau teulu N-Wasp a WAVE yn swyddogaeth TJ a metastasis.
  3. BDNf / NGF a'r rhaeadr metastatig.

Addysgu

Goruchwyliaeth ymchwil israddedig:

  • Elfen SSC o flwyddyn 1, 2, 3 a 4 C21 MB BCh, lleoliadau ymchwil a dewisol
  • Lleoliadau prosiect ymchwil PTY ac ad hoc
  • Prosiectau rhyng-gyfrifedig
  • Prosiectau Ffarmacoleg Feddygol

Addysgu israddedig:

  • Prosiect Llenyddiaeth SSC blwyddyn 1 C21 MB BCh
  • PCS blwyddyn 1 C21 MB BCh

Addysgu ôl-raddedig:

  • MSc Canser a Therapeutics
  • MSc yn goruchwylio prosiect

Bywgraffiad

Career overview

Team Leader and Senior Lecturer: My research interests are investigating the role of Tight Junctions in the progression of cancer, and investigating how they can be modulated in both benign and pathological disease. I also have a continued interest in angiogenic factors and their role in metastasis. I supervise a large number of PhD, MD and visiting research fellows, attend national and international conferences (I have presented over 70 papers), write original research papers, reviews (many invited) and book chapters (invited). During the last 10 years, I was employed to work on 2 major projects as a research scientist: the first was sponsored by Abbot Pharmaceuticals (2003-2005) and involved investigating factors that could affect benign and malignant breast cancer cells in regards to cellular “leakiness”. This directly involved Tight Junctions as controllers.

2003 - 2020 Lecturer: Developing a research focau on Tight Junctions in cacner and metastatic disease. From 2006-2011 I was employed as the research scientist on a Cancer-Research Wales sponsored program grant. This involved the examination of Hepatocyte Growth Factor (HGF) and how this cytokine influences stem cells markers in breast and prostate cancer (funded by Cancer Research Wales). This work led to the award of the AACR-CTR-SABSC-Susan G, Komen for the Cure Scholarship for “Evaluation of the distribution of stem cell markers (PSCA, CD44, CD49b and CD133) in human breast cancer reveals correlation with clinical progression and metastatic disease in ductal carcinoma”.

March 2000 - July 2003 Research Fellow: Undertook a program of research to determine, using molecular, cellular and in vivo techniques, the mechanisms of cancer metastasis in particular the possible application of newly discovered antagonists to growth factors as an anti-metastasis tool (Susan G. Komen Breast Cancer Foundation for a study on 'NK4, a HGF/SF antagonist, as a new anti-metastatic-agent in breast cancer). This was followed by a project sponsored by CR-UK that involved the creation of an anti-metastasis/angiogenesis compound. I also began to research the role that Tight Junctions and their molecular constituents may have in breast cancer metastasis. This research was recognised at the 2002 San Antonio Breast Cancer Symposium, where I was honoured with a Astra-Zeneca Scholar Awards showing that tight junction molecules are lost in those patients with metastatic breast cancer.

June 1997- March 2000 Research Fellow: Establishing the role of fibroblasts in the process of tissue repair and cancer metastasis, identifying fibroblast derived factors responsible for the regulatory effect of fibroblasts, in the promotion of angiogenesis, at the Wound Healing Research Unit, University Department of Surgery at UWCM, Cardiff, UK for Prof. K.G. Harding (funded by Smith & Nephew/Advanced Tissue Science Joint Venture).

Education and qualifications

  • 2020: iACT Manager
  • 2013: University Leadership and Management (ILM).
  • 1996: PhD: The Use of 16S Ribosomal RNA to Investigate Microbial Diversity of River Epilithon at the Department of Pure & Applied Biology University of Wales College Cardiff.
  • 1992: BSc (hons) Microbiology & Genetics, Department of Pure & Applied Biology University of Wales College Cardiff. Honours Research Project: The Effect of Toxic Metal & Other External Factors on the Growth of the Basidiomycete Fungi Hypholoma fasciculare.

Anrhydeddau a dyfarniadau

BACR Travel Award to the 7th Chinese Conference on Oncology (CCO) and The 11th Cross-Strait Academic Conference on Oncology and the China-UK-Japan Gastro-intestinal Cancer Symposium, 2012.

AACR Scholar-in Training Award, funded by Susan G. Komen for the Cure at the CTRC-AACR San Antonio Breast Cancer Symposium, Texas, December 2009 for “Evaluation of the distribution of stem cell markers in human breast cancer reveals correlation with clinical progression and metastatic disease in ductal carcinoma".

Welsh Urologists March 2006 Asware N., Martin T.A., Matthews P.N., Jiang W.G. Welsh Urologists March 2003 Brown G.M., Martin T.A., Matthews P.N., Jiang W.G. “The expression of tight junction molecules in human bladder cancer”

San Antonio Breast Cancer Symposium, December 2004 Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG. “ROCK1 and the aggressive nature of breast cancer cells”.

Welsh Urologists March 2003 Brown G.M., Martin T.A., Matthews P.N., Jiang W.G. “The expression of tight junction molecules in human bladder cancer”

Astra-Zeneca Scholar at the San Antonio Breast Cancer Symposium, December 2002 for “Expression and distribution of tight junction molecules in breast cancer and their association with clinical outcomes” and invited give an oral presentation.

AACR Scholarship April 2002 Davies G, Martin TA, Parr C, Grimshaw D, Mason MD, Jiang WG. “NK4 reduced the growth of prostate cancer in vivo”.

Certificate of Merit at the American Society of Tissue Regeneration Conference, April 2001 for Martin TA, Jiang WG, and Harding KG. Effect of human fibroblast derived dermis on human tissue expansion. American Society of Tissue Regeneration Conference.

Aelodaethau proffesiynol

  • American Association of Cancer Research (AACR)
  • Women in Cancer Research (WICR)
  • British Association of Cancer Research
  • European Association of Cancer Research

Safleoedd academaidd blaenorol

2014-present –Group Leader, Cardiff-China Medical Research Collaborative

2003 to 2014 – Lecturer, Metastasis and Angiogenesis Research Group, Cardiff University

2000-2003 Research Fellow, Metastasis and Angiogenesis Research Group, Cardiff University

1997- 2000 Research Fellow, Wound Healing Research Unit, University Department of Surgery at University of Wales College of Medicine

1996 Research Assistant,  University of Wales Cardiff

Pwyllgorau ac adolygu

2004-present HTRGC

2015-present ICAGE Health and Safety Team

2017 DCG EDHR Committee

Meysydd goruchwyliaeth

Goruchwyliaeth ymchwil ôl-raddedig Mutli-ddisgyblaeth: PhD a MD

Myfyrwyr / Myfyrwyr presennol:

  • Henson Han Gao PhD (ar y cyd â Pheirianneg, Yr Athro Johannes Benedikt)

Prosiectau Ffarmacoleg, MSc a Intercalated diweddar (2024):

  • Chelsea Stevens
  • Y Dywysoges Musah Braimoh
  • Nikoletta Mouskoh
  • Weiyi Hu
  • Patrick Brown

Cymrodyr Ymchwil Rhyngwladol Diweddar:

  • Sue Xiashan Cao
  • Wenjing Gong
  • Shawn Zhang
  • Ling Xin
  • Huishan Zhao

Goruchwyliaeth gyfredol

Yufei Lou

Yufei Lou

Myfyriwr ymchwil

Rhiannon Yu

Rhiannon Yu

Myfyriwr ymchwil

Wenxiao Ji

Wenxiao Ji

Myfyriwr ymchwil

Milad Eshmela

Milad Eshmela

Myfyriwr ymchwil

Amber Li

Amber Li

Myfyriwr ymchwil

Niamh O'Neill

Niamh O'Neill

Myfyriwr ymchwil

Cai Wang

Cai Wang

Myfyriwr ymchwil

Prosiectau'r gorffennol

Goruchwyliaeth lwyddiannus o dros 40 o brosiectau PhD, MPhil a MD.

Ymgysylltu

Array

Arbenigeddau

  • Sgrinio canser, atal a diagnosis cynnar
  • Bioleg celloedd canser
  • Clefyd metastatig
  • Canser y fron a chanser solet arall
  • Triniaethau canser newydd