Dr Tracey Martin
(hi/ei)

: Ar gael fel goruchwyliwr ôl-raddedig

Timau a rolau for Tracey Martin

Uwch Ddarlithydd mewn Bioleg Cell a Tumour, Cyfarwyddwr Ymchwil Ôl-raddedig
Yr Ysgol Meddygaeth

Ar ôl PhD mewn Bioleg Moleciwlaidd ym Mhrifysgol Caerdydd, dechreuais yrfa ôl-ddoethurol yng Ngholeg Meddygaeth Prifysgol Cymru, gan ymchwilio i rôl Ffactor Twf Hepatocyte (HGF) ar endothelia. Arweiniodd hyn at y cyfle i archwilio HGF a'i wrthwynebydd NK4 mewn canser. Ers 1998, rwyf wedi bod yn ymwneud ag ymchwilio i rôl cyffyrdd tynn mewn canser (yn ystod metastasis) ac mewn endothelia (yn ystod angiogenesis). Mae fy niddordebau ymchwil yn cynnwys ymchwilio i sut y gellir modiwleiddio cyffyrdd tynn i reoli datgysylltiad a goresgyniad celloedd canser, ynghyd â diddordeb parhaus mewn ffactorau angiogenig a'u rôl mewn metastasis. Mae gen i ddiddordeb penodol mewn metastasis yr ymennydd ac mae rôl cyffyrdd tynn yn ennill y rhwystr gwaed-ymennydd. Mae fy nhîm yn reearching yn weithredol y mecanweithiau sylfaenol dan sylw a thargedau therapiwtig posibl / therapïau newydd.

Rolau eraill:

Cyfarwyddwr Ymchwil Ôl-raddedig yr Ysgol Feddygaeth
Dirprwy Arweinydd Ymchwil Ôl-raddedig, Is-adran Canser a Geneteg
Cyfarwyddwr Rhaglenni Ysgolheigion Gaeaf a Haf Rhyngwladol yr Ysgol Feddygaeth
Cadeirydd pwyllgor Cydraddoldeb, Amrywiaeth a Chynhwysiant yr Is-adran Canser a Geneteg
Hyrwyddwr Lles Ysgol Feddygaeth

Date
Type

2021

Xin, L. et al. 2021. SIKs suppress tumor function and regulate drug resistance in breast cancer. American Journal of Cancer Research 11(7), pp. 3537-3557.
Martin, T. A., Li, A. X., Sanders, A. J., Ye, L., Frewer, K., Hargest, R. and Jiang, W. G. 2021. NUPR1 and its potential role in cancer and pathological conditions (Review). International Journal of Oncology 58(5), article number: 21. (10.3892/ijo.2021.5201)
Liu, C., Jiang, W., Zhang, L., Hargest, R. and Martin, T. A. 2021. SIPA1 Is a modulator of HGF/MET induced tumour metastasis via the regulation of tight junction-based cell to cell barrier function. Cancers 13(7), article number: 1747. (10.3390/cancers13071747)
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P. and Jiang, W. G. 2021. Location, function and role of stromal cell-derived factors and possible implications in cancer. International Journal of Molecular Medicine 47(2), pp. 435-443. (10.3892/ijmm.2020.4811)

2020

Gong, W., Martin, T. A., Sanders, A. J., Hargest, R., Jiang, A., Sun, P. and Jiang, W. G. 2020. Influence of anaesthetics on the production of cancer cell motogens, stromal cell-derived factor-1 and hepatocyte growth factor by fibroblasts. Oncology Letters 21(2), article number: 140. (10.3892/ol.2020.12401)
Liu, C., Jiang, W., Hargest, R. and Martin, T. 2020. The role of SIPA1 in the development of cancer and metastases (Review). Molecular and Clinical Oncology 13(4), article number: 32. (10.3892/mco.2020.2102)
Cong, Y. et al. 2020. Tim-3 promotes cell aggressiveness and paclitaxel resistance through the NF-κB /STAT3 signalling pathway in breast cancer cells. Chinese Journal of Cancer Research 32(5), pp. 564-579. (10.21147/j.issn.1000-9604.2020.05.02)
Wazir, U., Tayeh, S., Orakzai, M. A., Martin, T. A., Jiang, W. G. and Mokbel, K. 2020. Stratification using hTERT and stem cell markers confers a good prognosis in invasive breast cancer. Cancer Genomics and Proteomics 17(2), pp. 169-174. (10.21873/cgp.20177)
Zhao, Z. et al. 2020. Abstract P3-01-18: Kinase D interacting substrate 220 (Kidins220) and disease progression of breast cancer, the role of heat shock protein90 (HSP90). Presented at: San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 10-14 December 2019, Vol. 80. Vol. 4, Sup. American Association for Cancer Research pp. P3-01-18., (10.1158/1538-7445.SABCS19-P3-01-18)
Zhao, Z. et al. 2020. Abstract P2-07-01: Kidins220 (kinase D interacting substrate 220) has a connection with neutrotrophic related factors, BDNF and NGF, in human breast cancer. Presented at: San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 10-14 December 2019, Vol. 80. Vol. 4, Sup. pp. P2-07-01., (10.1158/1538-7445.SABCS19-P2-07-01)

2019

Xu, Y., Jiang, W. -., Wang, H. -., Martin, T., Zeng, Y. -., Zhang, J. and Qi, Y. -. 2019. BDNF activates TrkB/PLCγ1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. European Review for Medical and Pharmacological Sciences 23(12), pp. 5093-5100. (10.26355/eurrev_201906_18173)
Wazir, U., Orakzai, M. M. A. W., Martin, T. A., Jiang, W. G. and Mokbel, K. 2019. Correlation of TERT and stem cell markers in the context of human breast cancer. Cancer Genomics and Proteomics 16(2), pp. 121-127. (10.21873/cgp.20117)

2018

Jia, J., Martin, T. A., Ye, L., Meng, L., Xia, N., Jiang, W. G. and Zhang, X. 2018. Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways. International Journal of Molecular Medicine 41(1), pp. 275-283. (10.3892/ijmm.2017.3224)

2017

Xin, L., Liu, Y. H., Martin, T. A. and Jiang, W. G. 2017. The era of multigene panels comes? The clinical utility of Oncotype DX and MammaPrint. World Journal of Oncology 8(2), pp. 34-40. (10.14740/wjon1019w)
Zhao, H., Owen, S., Davies, E. L., Jiang, W. G. and Martin, T. A. 2017. The effect of aurora kinase inhibitor on adhesion and migration in human breast cancer cells and clinical implications. World Journal of Oncology 8(5), pp. 151-161. (10.14740/wjon1062w)
Ismail, A. F. et al. 2017. PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells. Biochemical Journal 474(8), pp. 1333-1346. (10.1042/BCJ20160875)
Frugtniet, B. A., Martin, T. A., Zhang, L. and Jiang, W. G. 2017. Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion. BMC Cancer 17(1), article number: 224. (10.1186/s12885-017-3219-3)
Yang, X. et al. 2017. A novel NHERF1 mutation in human breast cancer and effects on malignant progression. Anticancer Research 37(1), pp. 67-73. (10.21873/anticanres.11290)
Telford, E., Jiang, W. G. and Martin, T. A. 2017. HAVcR-1 involvement in cancer progression. Histology and Histopathology 32, pp. 121-128. (10.14670/HH-11-817)
Gu, Y. et al. 2017. NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway. Oncotarget 8(5), pp. 7753-7765. (10.18632/oncotarget.13949)

2016

Liu, R., Martin, T. A., Jordan, N., Ruge, F., Ye, L. and Jiang, W. G. 2016. Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer. International Journal of Oncology 48(6), pp. 2488-2496. (10.3892/ijo.2016.3462)
Zhao, H., Yu, H., Martin, T. A., Teng, X. and Jiang, W. G. 2016. The role of JAM-B in cancer and cancer metastasis (Review). Oncology Reports 36, pp. 3-9. (10.3892/or.2016.4773)
Zhao, H., Yu, H., Martin, T. A., Zhang, Y., Chen, G. and Jiang, W. G. 2016. Effect of junctional adhesion molecule-2 expression on cell growth, invasion and migration in human colorectal cancer. International Journal of Oncology 48(3), pp. 929-936. (10.3892/ijo.2016.3340)
Martin, T. A., Jordan, N., Davies, E. L. and Jiang, W. G. 2016. Metastasis to bone in human cancer is associated with loss of occludin expression. Anticancer Research 36(3), pp. 1287-1294.
Zhao, H. et al. 2016. The clinical implications of RSK1-3 in human breast cancer. Anticancer Research 36(3), pp. 1267-1274.
Yang, X., Si, Y., Martin, T. A. and Jiang, W. G. 2016. The impact of TIMM17A on aggressiveness of human breast cancer cells. Anticancer Research 36(3), pp. 1237-1241.
Jia, W. et al. 2016. Expression of the Epithelial-Mesenchymal-Transition (EMT) markers, Twist, Slug, Snail, E- and N-cadherins and the association with clinical and pathological features of human pituitary adenomas [Abstract]. European Journal of Cancer 51(S3), pp. S592-S593., article number: 2925. (10.1016/S0959-8049(15)30055-1)

2015

Liu, R., Martin, T. A., Jordan, N. J., Ruge, F., Ye, L. and Jiang, W. G. 2015. Metastasis suppressor 1 expression in human ovarian cancer: the impact on cellular migration and metastasis. International Journal of Oncology 47(4), pp. 1429-1439. (10.3892/ijo.2015.3121)
Tan, Y., Sanders, A. J., Xie, Y., Martin, T. A., Owen, S., Ruge, F. and Jiang, W. G. 2015. Interleukin-24 (IL-24) expression and biological impact on HECV endothelial cells.. Cancer Genomics and Proteomics 12(5), pp. 243-250.
Owen, S., Martin, T. A., Dart, D. A., Ablin, R. J., Mason, M. D. and Jiang, W. G. 2015. The prostate Transglutaminase, TGase-4, is potentially linked to the junctional proteins at tight junctions of prostate tissues and prostate cancer cells [Abstract]. European Journal of Cancer 51(S3), pp. S481., article number: 2516. (10.1016/S0959-8049(15)30048-4)
Owen, S. et al. 2015. An investigation of Amphiphysin II transcript expression in pituitary adenomas [Abstract]. European Journal of Cancer 51(S3), pp. S580-S580., article number: 2806. (10.1016/S0959-8049(15)30053-8)
Jiang, W. G. et al. 2015. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. Journal of Translational Medicine 13, article number: 280. (10.1186/s12967-015-0639-1)
Ali, A. Y. et al. 2015. Anti-metastatic and cytotoxic properties of frankincense and scented myrrh. Anticancer Research 35(7), pp. 4310-4311.
Martin, T. A., Jordan, N., Meyers, I. and Jiang, W. G. 2015. Comparison of blood brain barrier endothelia reveals a differential expression of tight junction proteins [Abstract]. Anticancer Research 35(7), pp. 4357-4358.
Liu, R., Jordan, N., Martin, T. A., Ruge, F., Ye, L. and Jiang, W. G. 2015. Metastasis suppressor 1 (MTSS1) expression in human ovarian cancer; the impact on cellular migration and metastasis [Abstract]. Anticancer Research 35(7), pp. 4342-4342.
Jia, W. et al. 2015. Association of mta-1 expression in pituitary tumours with bone invasion. Anticancer Research 35(7), pp. 4360.
Martin, T. A. and Tiang, W. G. 2015. The blood brain barrier and the prevention of metastatic disease. Anticancer Research 35(7), pp. 4298-4299.
Frugtniet, B., Jiang, W. G. and Martin, T. A. 2015. Investigating the effect of NWASP (Neural Wiskott-Aldrich Syndrome Protein) inhibitors on human lung cancer cell behaviour. Anticancer Research 35(7), pp. 4348-4349.
Fang, X., Jiang, W. G. and Martin, T. A. 2015. The role of claudin-5 in the cell-cell adhesion of human keratinocytes. Anticancer Research 35(7), pp. 4367.
Martin, T. A., Telford, E. and Jiang, W. G. 2015. HAVCR1 is a potential prognostic factor in human breast cancer. Anticancer Research 35(7), pp. 4327.
Jia, W. et al. 2015. Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas. Cancer Genomics and Proteomics 12(3), pp. 113-118.
Frugtniet, B., Jiang, W. G. and Martin, T. A. 2015. Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis. Breast Cancer: Targets and Therapy 2015(7), pp. 99-109. (10.2147/BCTT.S59006)
Men, W., Martin, T. A., Ruge, F., Zhang, N., Du, P., Yang, Y. and Jiang, W. G. 2015. Expression of claudins in human clear cell renal cell carcinoma. Cancer Genomics and Proteomics 12(1), pp. 1-8.
Jia, W., Zhu, J., Martin, T. A., A, J., Sanders, A. J. and Jiang, W. 2015. Epithelial-mesenchymal transition (EMT) markers in human pituitary adenomas indicate a clinical course. Anticancer Research 35(5), pp. 2635-2643.

2014

Martin, T. A. 2014. The role of tight junctions in cancer metastasis. Seminars in Cell and Developmental Biology 36, pp. 224-231. (10.1016/j.semcdb.2014.09.008)
Martin, T. A., Ruge, F., Harding, K. G. and Jiang, W. G. 2014. Brain-derived neurotrophic factor (bdnf) is a novel therapeutic agent in human wound healing [Abstract]. Wound Repair and Regeneration 22(5), pp. A91. (10.1111/wrr.12218)
Ye, L., Sun, P., Sanders, A. J., Martin, T. A., Lane, J., Mason, M. D. and Jiang, W. G. 2014. Therapeutic potential of capillary morphogenesis gene 2 extracellular vWA domain in tumour-related angiogenesis. International Journal of Oncology 45(4), pp. 1565-1573. (10.3892/ijo.2014.2533)
Martin, T. A., Mason, M. D. and Jiang, W. G. 2014. HGF and the regulation of tight junctions in human prostate cancer cells. Oncology Reports 32(1), pp. 213-224. (10.3892/or.2014.3219)
Feng, X., Jia, S., Martin, T. A. and Jiang, W. G. 2014. Regulation and involvement in cancer and pathological conditions of MAGI1, a tight junction protein. Anticancer Research 34(7), pp. 3251-3256.
Lane, J., Martin, T. A., Weeks, H. P. and Jiang, W. G. 2014. Structure and role of WASP and WAVE in Rho GTPase signalling in cancer. Cancer Genomics and Proteomics 11(3), pp. 155-165.
Jia, W., Lu, R., Martin, T. A. and Jiang, W. G. 2014. The role of claudin-5 in blood-brain barrier ( BBB) and brain metastases (Review). Molecular Medicine Reports 9(3), pp. 779-785. (10.3892/mmr.2013.1875)
Sun, T. T. et al. 2014. Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843(3), pp. 618-628. (10.1016/j.bbamcr.2013.12.013)
Martin, T. A. and Jiang, W. G. 2014. Evaluation of the expression of stem cell markers in human breast cancer reveals a correlation with clinical progression and metastatic disease in ductal carcinoma. Oncology Reports 31(1), pp. 262-272. (10.3892/or.2013.2813)
Frugtniet, B., Martin, T. A., Harding, K. G. and Jiang, W. G. 2014. nWASP (neural Wiskott-Aldrich syndrome protein) is a novel therapeutic target in human wound healing [Conference Abstract]. Wound Repair and Regeneration 22(5), pp. A80-A80. (10.1111/wrr.12218)
Jia, J., Martin, T. A., Ye, L. and Jiang, W. G. 2014. FAP-alpha (Fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway. BMC Cell Biology 15, article number: 16. (10.1186/1471-2121-15-16)

2013

Martin, T. A., Lane, J., Harrison, G. M. and Jiang, W. G. 2013. The expression of the Nectin complex in human breast cancer and the role of Nectin-3 in the control of tight junctions during metastasis. PLoS ONE 8(12), article number: e82696. (10.1371/journal.pone.0082696)
Yang, X., Martin, T. A. and Jiang, W. G. 2013. Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Experimental and Therapeutic Medicine 6(6), pp. 1475-1481. (10.3892/etm.2013.1330)
Ye, L., Sun, P., Martin, T. A., Sanders, A. J., Mason, M. D. and Jiang, W. G. 2013. Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 31(8), pp. 1576-1583. (10.1016/j.urolonc.2012.05.006)
Martin, T. A. and Jiang, W. G. 2013. Regulation of barrier function in human breast cancer can be controlled by the ROCK signalling pathway via interaction with SIPA-1 [Abstract]. European Journal of Cancer 49, pp. S132-S132.
Martin, T. A., Mason, M. D. and Jiang, W. G. 2013. HGF and the regulation of tight junctions in human prostate cancer cells. European Journal of Cancer 49, pp. S132-S132.
Wang, Y., Martin, T. A. and Jiang, W. G. 2013. HAVcR-1 expression in human colorectal cancer and its effects on colorectal cancer cells in vitro.. Anticancer Research 33(1), pp. 207-214.
Martin, T. A., Lane, J., Ozupek, H. and Jiang, W. G. 2013. Claudin-20 promotes an aggressive phenotype in human breast cancer cells. Tissue Barriers 1(3), article number: e26518. (10.4161/tisb.26518)
Martin, T. A., Ye, L., Sanders, A. J., Lane, J. and Jiang, W. G. 2013. Cancer invasion and metastasis: molecular and cellular perspective. In: Jandial, R. ed. Metastatic Cancer Clinical and Biological Perspectives. Austin, TX: Landes Bioscience, pp. 135-168.

2012

Yang, X., Martin, T. A. and Jiang, W. G. 2012. Biological influence of brain-derived neurotrophic factor on breast cancer cells. International Journal of Oncology 41(4), pp. 1541-1546. (10.3892/ijo.2012.1581)
Ji, K. et al. 2012. Expression of signal-induced proliferation-associated gene 1 (SIPA1), a rapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells. Cancer Genomics and Proteomics 9(5), pp. 321-327.
Escudero-Esparza, A., Jiang, W. G. and Martin, T. A. 2012. Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways. Journal of Experimental & Clinical Cancer Research 31(1), pp. 43-60. (10.1186/1756-9966-31-43)
Martin, T. A., Toms, A., Davies, L. M., Cheng, S. and Jiang, W. G. 2012. The clinical and biological implications of N-WASP expression in human colorectal cancer. Translational Gastrointestinal Cancer 1(1), pp. 10-20.
Li, X., Martin, T. A. and Jiang, W. G. 2012. COM-1/p8 acts as a tumour growth enhancer in colorectal cancer cell lines. Anticancer Research 32(4), pp. 1229-1237.

2011

Sanders, A. J., Martin, T. A., Ye, L., Mason, M. D. and Jiang, W. G. 2011. EPLIN is a negative regulator of prostate cancer growth and invasion. The Journal of Urology 186(1), pp. 295-301. (10.1016/j.juro.2011.03.038)
Martin, T. A., Harrison, G. M., Mason, M. D. and Jiang, W. G. 2011. HAVcR-1 reduces the integrity of human endothelial tight junctions. Anticancer Research 31(2), pp. 467-473.
Cheng, S., Martin, T. A., Teng, X. and Jiang, W. G. 2011. Putative breast tumor suppressor TACC2 suppresses the aggressiveness of breast cancer cells through a PLCγ pathway. Current Signal Transduction Therapy 6(1), pp. 55-64. (10.2174/157436211794109361)
Martin, T. A., Mason, M. D. and Jiang, W. G. 2011. Hepatocyte growth factor signalling in cancer metastasis. Current Signal Transduction Therapy 6(2), pp. 180-190. (10.2174/157436211795659991)
Lane, J., Martin, T. A. and Jiang, W. G. 2011. HGF and rhoGTPases in cancer cell motility. Current Signal Transduction Therapy 6(2), pp. 173-179. (10.2174/157436211795660052)
Escudero-Esparza, A., Jiang, W. G. and Martin, T. A. 2011. Claudin-5 participates in the regulation of endothelial cell motility. Molecular and Cellular Biochemistry 362(1-2), pp. 71-85. (10.1007/s11010-011-1129-2)
Martin, T. A., Mason, M. D. and Jiang, W. G. 2011. Tight junctions in cancer metastasis. Frontiers in Bioscience 16(3), pp. 898-936. (10.2741/3726)
Escudero-Esparza, A., Jiang, W. G. and Martin, T. A. 2011. The Claudin family and its role in cancer and metastasis. Frontiers in Bioscience 16(3), pp. 1069-1083. (10.2741/3736)
Mustafa, N., Martin, T. A. and Jiang, W. G. 2011. Metastasis tumour suppressor-1 and the aggressiveness of prostate cancer cells. Experimental and Therapeutic Medicine 2(1), pp. 157-162. (10.3892/etm.2010.184)
Minhas, U., Martin, T. A., Ruge, F., Harding, K. G. and Jiang, W. G. 2011. Pattern of expression of CCN family members Cyr61, CTGF and NOV in human acute and chronic wounds. Experimental and Therapeutic Medicine 2(4), pp. 641-645. (10.3892/etm.2011.256)
Awsare, N. S., Martin, T. A., Haynes, M. D., Matthews, P. N. and Jiang, W. G. 2011. Claudin-11 decreases the invasiveness of bladder cancer cells. Oncology Reports 25(6), pp. 1503-1509. (10.3892/or.2011.1244)

2010

Lane, J., Martin, T. A. and Jiang, W. G. 2010. Targeting RhoC by way of ribozyme trangene in human breast cancer cells and its impact on cancer invasion. World Journal of Oncology 1(1), pp. 7-13. (10.4021/wjon2010.01.1202)
Lane, J., Martin, T., McGuigan, C., Mason, M. and Jiang, W. 2010. The differential expression of hCNT1 and hENT1 i n breast cancer and the possible impact on breast cancer therapy. Journal of Experimental Therapeutics and Oncology 8(3), pp. 203-210.
Martin, T. A. and Jiang, W. G. 2010. Hepatocyte growth factor and cMET, new development in cancer therapies [Editorial]. Anti-Cancer Agents in Medicinal Chemistry 10(1), pp. 1.
Martin, T. A. and Jiang, W. G. 2010. Hepatocyte growth factor and its receptor signalling complex as targets in cancer therapy. Anti-Cancer Agents in Medicinal Chemistry 10(1), pp. 2-6.
Martin, T. A., Mansel, R. E. and Jiang, W. G. 2010. Loss of occludin leads to the progression of human breast cancer. International Journal of Molecular Medicine 26(5), pp. 723-734. (10.3892/ijmm_00000519)
Herman, F., Martin, T. A., Douglas-Jones, A., Kynaston, H. G., Mansel, R. E. and Jiang, W. G. 2010. Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer. Experimental and Therapeutic Medicine 1(1), pp. 153-160. (10.3892/etm_00000025)
Escudero-Esparza, A., Martin, T. A., Douglas-Jones, A., Mansel, R. E. and Jiang, W. G. 2010. PGF isoforms, PLGF-1 and PGF-2 and the PGF receptor, neuropilin, in human breast cancer: prognostic significance. Oncology Reports 23(2), pp. 537-544. (10.3892/or_00000667)

2009

Martin, T. A. and Jiang, W. G. 2009. Loss of tight junction barrier function and its role in cancer metastasis. Biochimica et Biophysica Acta (BBA) - Biomembranes 1788(4), pp. 872-891. (10.1016/j.bbamem.2008.11.005)
Minhas, U., Martin, T. A., Price, P. E., Harding, K. G. and Jiang, W. G. 2009. CCN family proteins in wound healing - a pivotal role? [Abstract]. Wound Repair and Regeneration 17(4), pp. A74. (10.1111/j.1524-475X.2009.00519.x)
Escudero-Esparza, A., Martin, T. A., Davies, M. L. and Jiang, W. G. 2009. PGF isoforms, PLGF-1 and PGF-2, in colorectal cancer and the prognostic significance. Cancer Genomics and Proteomics 6(4), pp. 239-246.

2008

Lane, J., Martin, T. A., Mansel, R. E. and Jiang, W. G. 2008. The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer. International Seminars in Surgical Oncology 5(1), article number: 23. (10.1186/1477-7800-5-23)
Jiang, W. G., Martin, T. A., Lewis-Russell, J. M., Douglas-Jones, A. G., Ye, L. and Mansel, R. E. 2008. Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome. Molecular Cancer 7, article number: 71. (10.1186/1476-4598-7-71)
Martin, T. A., Harrison, G. M., Watkins, G. and Jiang, W. G. 2008. Claudin-16 reduces the aggressive behavior of human breast cancer cells. Journal of Cellular Biochemistry 105(1), pp. 41-52. (10.1002/jcb.21797)
Sanders, A. J., Parr, C., Martin, T. A., Lane, J., Mason, M. D. and Jiang, W. G. 2008. Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation. Journal of Cellular Physiology 216(3), pp. 780-789. (10.1002/jcp.21460)
Lane, J., Martin, T. A., Watkins, G., Mansel, R. E. and Jiang, W. G. 2008. The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. International Journal of Oncology 33(3), pp. 585-593. (10.3892/ijo_00000044)
Davies, G., Martin, T. A., Ye, L., Lewis-Russell, J. M., Mason, M. D. and Jiang, W. G. 2008. Phospholipase-C gamma-1 (PLCγ-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 26(4), pp. 386-391. (10.1016/j.urolonc.2007.06.003)
Goyal, A., Martin, T. A., Mansel, R. E. and Jiang, W. G. 2008. Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome. World Journal of Surgical Oncology 6, pp. 56-61. (10.1186/1477-7819-6-56)

2007

Parr, C. et al. 2007. Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients. Clinical Cancer Research 13(12), pp. 3568-3576. (10.1158/1078-0432.CCR-06-2357)
Martin, T. A., Pereira, G., Watkins, G., Mansel, R. E. and Jiang, W. G. 2007. N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. Clinical & Experimental Metastasis 25(2), pp. 97-108. (10.1007/s10585-007-9120-8)

2006

Lane, J., Martin, T. A. and Jiang, W. G. 2006. Novel protein binding partners for Rho-associated serine-threonine protein kinases (ROCKS) in breast cancer cells [Abstract]. Breast Cancer Research and Treatment 100(1 Supp), pp. S298-S298., article number: 6127.
Jiang, W. G., Davies, G., Martin, T. A., Kynaston, H., Mason, M. D. and Fodstad, O. 2006. Com-1/p8 acts as a putative tumour suppressor in prostate cancer. International Journal of Molecular Medicine 18(5), pp. 981-986.
Harrison, G., Davies, G., Martin, T. A., Mason, M. D. and Jiang, W. G. 2006. The influence of CD44v3-v10 on adhesion, invasion and MMP-14 expression in prostate cancer cells. Oncology Reports 15(1), pp. 199-206. (10.3892/or.15.1.199)
Sanders, A. J., Parr, C., Davies, G., Martin, T. A., Lane, J., Mason, M. D. and Jiang, W. G. 2006. Genetic reduction of matriptase-1 expressionj is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo. Journal of Experimental Therapeautics and Oncology 6(1), pp. 39-48.
Sanders, A. J., Parr, C., Davies, G., Martin, T. A., Lane, J., Mason, M. D. and Jiang, W. G. 2006. Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo. Journal of Experimental Therapeutics and Oncology 6(1), pp. 39-48.

2005

Lane, J., Martin, T. and Jiang, W. G. 2005. Targeting Rho-C by way of ribozyme transgene in human breast cancer cells and its impact on cancer invasion. Breast Cancer Research and Treatment 94(1), pp. S188-S189., article number: 4068. (10.1007/s10549-005-1234-6)
Lane, J., Martin, T. A. and Jiang, W. G. 2005. ROCK inhibitor Y-27632 suppresses the effect of HGF in human breast cancer cells [Abstract]. Breast Cancer Research and Treatment 94(1 Supp), pp. S193-S194., article number: 4082.
Jiang, W. G. et al. 2005. Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy. Clinical Cancer Research 11(16), pp. 6012-6019. (10.1158/1078-0432.CCR-05-0275)
Martin, T. A., Watkins, G., Lane, J. and Jiang, W. G. 2005. Assessing microvessels and angiogenesis in human breast cancer, using VE-cadherin. Histopathology 46(4), pp. 422-430. (10.1111/j.1365-2559.2005.02104.x)
Martin, T. A., Goyal, A., Watkins, G. and Jiang, W. G. 2005. Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Annals of Surgical Oncology 12(6), pp. 488-496. (10.1245/ASO.2005.04.010)
Jiang, W., Davies, G., Martin, T. A., Parr, C., Mason, M. D. and Mansel, R. E. 2005. Manipulation of expression of MMP-14 and its impact on the invasivess and progression of breast cancer cells [Abstract]. Breast Cancer Research and Treatment 94, pp. S187-S187.

2003

Jiang, W. G. et al. 2003. Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET. Clinical Cancer Research 9(11), pp. 4274-4281.
Davies, G. et al. 2003. The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesisin vivo. International Journal of Cancer 106(3), pp. 348-354. (10.1002/ijc.11220)
Martin, T. A. et al. 2003. Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis 24(8), pp. 1317-1323. (10.1093/carcin/bgg072)

2001

Jiang, W. G., Grimshaw, A. D., Lane, J., Martin, T. A., Abounader, R., Laterra, J. and Mansel, R. E. 2001. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells. Clinical Cancer Research 7, pp. 2555-2562.
Martin, T. A., Mansel, R. E. and Jiang, W. G. 2001. Hepatocyte growth factor modulates vascular endothelial-cadherin expresssion in human endothelial cells. Clinical Cancer Research 7(3), pp. 734-737.
Martin, T. A. and Jiang, W. G. 2001. Tight junctions and their role in cancer metastasis.. Histology and Histopathology 16, pp. 1183-1195.
Martin, T. A., Harding, K. G. and Jiang, W. G. 2001. Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin. European Journal of Clinical Investigation 31(11), pp. 931-938. (10.1046/j.1365-2362.2001.00914.x)

1999

Jiang, W. G., Hiscox, S. E., Parr, C., Martin, T. A., Matsumoto, K., Nakamura, T. and Mansel, R. E. 1999. Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells. Clinical Cancer Research 5(11), pp. 3695-3703.
Jiang, W. G., Martin, T. A., Matsumoto, K., Nakamur, T. and Mansel, R. E. 1999. Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells.. Journal of Cellular Physiology 181(2), pp. 219-329. (10.1002/(SICI)1097-4652(199911)181:2<319::AID-JCP14>3.0.CO;2-S)

Cyffyrdd celloedd fel cyfryngwyr neu rwystrau i ledaenu celloedd a'r rheoleiddwyr ohono

Mae'r Cyffordd Dynn (TJ) yn rhanbarth lle mae pilen plasma celloedd cyfagos yn ffurfio cyfres o gysylltiadau sy'n ymddangos eu bod yn atal y gofod allgellog yn llwyr gan greu rhwystr rhynggellog a ffens trylediad intramembrane.
Mewn celloedd epithelaidd, mae'r TJ yn gweithredu mewn modd gludiog a gall atal datgysylltu celloedd tra bod TJs mewn celloedd endothelaidd yn gweithredu fel rhwystr lle gall moleciwlau a chelloedd llidiol basio.
Mae corff sylweddol o waith bellach yn bodoli ar TJ a'u rôl mewn nifer o glefydau.
Mae TJs wedi cael eu cydnabod fel chwaraewyr allweddol mewn metastasis canser. Awgrymodd astudiaethau cynnar fod cysylltiad rhwng lleihau proteinau TJ a gwahaniaethu tiwmorau a chynyddu tystiolaeth arbrofol wedi dod i'r amlwg i osod TJs yn y rheng flaen fel y strwythur y mae'n rhaid i gelloedd canser ei oresgyn er mwyn metastasize.
Mae rhyngweithio a threiddiad yr endotheliwm fasgwlaidd gan gelloedd canser datgysylltiol yn gam pwysig wrth ffurfio metastases canser.
Mae angen newidiadau mewn celloedd tiwmor ac endothelaidd ar gyfer twf a lledaeniad celloedd canser yn llwyddiannus a bod y newidiadau hyn ychydig yn debyg.
Mae newid mewn celloedd canser trwy uwchreoleiddio neu isreoleiddio proteinau TJ perthnasol yn arwain at golli cysylltiad celloedd-gell, atal cyswllt celloedd, gan arwain at dwf heb reolaeth, colli adlyniad i'r islawr a diraddio.
Rhaid i'r rhain fod yn golled gydamserol o gysylltiad cell-gell yn endotheliwm a modwleiddio proteinau TJ sy'n ymwneud â hwyluso hynt y celloedd canser trwy'r rhwystr hwn.
Rydym wedi dangos bod mynegiant gwahaniaethol o nifer o broteinau TJ trawsmembrane, yn enwedig Occludin, Claudin-5 a'r Nectin a'u bod yn cydberthyn ag aflonyddwch TJs mewn tiwmorau.
Mae modiwleiddio mynegiant o'r proteinau hyn yn arwain at newidiadau allweddol mewn swyddogaeth rhwystr gan arwain at ddilyniant canser a dilyniant metastasis.

Meysydd ymchwil

Triniaethau minimally ymledol:

Technoleg therapiwtig lleiaf ymledol newydd

rhwystr ymennydd gwaed (BBB):

Modulators o ddynameg BBB
Cymhariaeth o wahanol gelloedd endothelaidd BBB a rôl HGF mewn metastasis ymennydd.

HAVcR-1:

Swyddogaeth HAVcR-1 mewn canser y fron a'i reolaeth ar swyddogaeth rhwystr.
HAVcR-1 fel modulator sylweddol o signalau HGF mewn metastasis canser y prostad trwy reoli TJs.

Occludin ac MARVELD3:

Rheoli swyddogaeth TJ gan Occludin / MARVELD3 ac isofformau gwahanol mewn metastasis canser y fron a colorectal.

Arwyddion a rheolaeth ar TJs:

Sut mae SIPA-1 wedi'i integreiddio i lwybr signalau HGF swyddogaeth TJ mewn canser y fron.
Archwilio aelodau teulu N-Wasp a WAVE yn swyddogaeth TJ a metastasis.
BDNf / NGF a'r rhaeadr metastatig.

Goruchwyliaeth ymchwil israddedig:

Elfen SSC o flwyddyn 1, 2, 3 a 4 C21 MB BCh, lleoliadau ymchwil a dewisol
Lleoliadau prosiect ymchwil PTY ac ad hoc
Prosiectau rhyng-gyfrifedig
Prosiectau Ffarmacoleg Feddygol

Addysgu israddedig:

Prosiect Llenyddiaeth SSC blwyddyn 1 C21 MB BCh
PCS blwyddyn 1 C21 MB BCh

Addysgu ôl-raddedig:

MSc Canser a Therapeutics
MSc yn goruchwylio prosiect

Trosolwg o'r gyrfa

Arweinydd Tîm ac Uwch Ddarlithydd: Fy niddordebau ymchwil yw ymchwilio i rôl Cyffyrdd Tynn yn dilyniant canser, ac ymchwilio i sut y gellir eu modiwleiddio mewn clefyd anfalaen a patholegol, gyda ffocws ar glefyd metastatig yr ymennydd. Mae gen i ddiddordeb parhaus mewn ffactorau angiogenig a'u rôl mewn metastasis. Rwy'n goruchwylio nifer fawr o PhD, MD a chymrodyr ymchwil gwadd, mynychu cynadleddau cenedlaethol a rhyngwladol (rwyf wedi cyflwyno dros 70 o bapurau), ysgrifennu papurau ymchwil gwreiddiol, adolygiadau (llawer wedi'u gwahodd) a phenodau llyfrau (gwahoddedig). Yn ystod y 10 mlynedd diwethaf, cefais fy nghyflogi i weithio ar 2 brosiect mawr fel gwyddonydd ymchwil: noddwyd y cyntaf gan Abbot Pharmaceuticals (2003-2005) ac roedd yn cynnwys ymchwilio i ffactorau a allai effeithio ar gelloedd canser y fron anfalaen a malaen mewn perthynas â "gollyngiadau" cellog. Roedd hyn yn ymwneud yn uniongyrchol â Tight Junctions fel rheolwyr.

2003 - 2020 Darlithydd: Datblygu ffocau ymchwil ar Gyffyrdd Tynn mewn cacner a chlefyd metastatig. Rhwng 2006-2011 cefais fy nghyflogi fel gwyddonydd ymchwil ar grant rhaglen a noddir gan Ymchwil Canser Cymru. Roedd hyn yn cynnwys archwilio Ffactor Twf Hepatocyte (HGF) a sut mae'r cytocin hwn yn dylanwadu ar farcwyr bôn-gelloedd mewn canser y fron a'r prostad (a ariennir gan Ymchwil Canser Cymru). Arweiniodd y gwaith hwn at ddyfarnu'r AACR-CTR-SABSC-Susan G, Komen ar gyfer yr Ysgoloriaeth Cure ar gyfer "Gwerthuso dosbarthiad marcwyr bôn-gelloedd (PSCA, CD44, CD49b a CD133) mewn canser y fron dynol yn datgelu cydberthynas â dilyniant clinigol a chlefyd metastatig mewn carcinoma ductal".

Mawrth 2000 - Gorffennaf 2003 Cymrawd Ymchwil: Ymgymerodd â rhaglen o ymchwil i bennu, gan ddefnyddio technegau moleciwlaidd, cellog ac in vivo, mecanweithiau metastasis canser yn enwedig cymhwyso posibl gwrthwynebwyr sydd newydd eu darganfod i ffactorau twf fel offeryn gwrth-metastasis (Sefydliad Canser y Fron Susan G. Komen ar gyfer astudiaeth ar 'NK4, gwrthwynebydd HGF / SF, fel asiant gwrth-metastatig newydd mewn canser y fron). Dilynwyd hyn gan brosiect a noddwyd gan CR-UK a oedd yn cynnwys creu cyfansoddyn gwrth-metastasis/angiogenesis. Dechreuais hefyd ymchwilio i'r rôl y gall Cyffyrdd Tynn a'u cyfansoddion moleciwlaidd gael mewn metastasis canser y fron. Cydnabuwyd yr ymchwil hon yn Symposiwm Canser y Fron San Antonio 2002, lle cefais fy anrhydeddu â Gwobrau Ysgolhaig Astra-Zeneca sy'n dangos bod moleciwlau cyffordd dynn yn cael eu colli yn y cleifion hynny â chanser y fron metastatig.

Mehefin 1997 - Mawrth 2000 Cymrawd Ymchwil: Sefydlu rôl ffibroblastau yn y broses o atgyweirio meinwe a metastasis canser, nodi ffactorau sy'n deillio o ffibroblastau sy'n gyfrifol am effaith reoleiddiol ffibroblastau, wrth hyrwyddo angiogenesis, yn yr Uned Ymchwil Iachau Clwyfau, Adran Llawfeddygaeth y Brifysgol yn Y Drindod Dewi Sant, Caerdydd, y DU ar gyfer yr Athro K.G. Harding (a ariennir gan Smith & Nephew/Advanced Tissue Science Joint Venture).

Addysg a chymwysterau

2020: Rheolwr iACT
2013: Arweinyddiaeth a Rheolaeth y Brifysgol (ILM).
1996: PhD: Defnyddio RNA ribosomaidd 16S i ymchwilio i amrywiaeth microbaidd Afon Epilithon yn yr Adran Bioleg Bur a Chymhwysol, Coleg Prifysgol Cymru, Caerdydd.
1992: BSc (anrh) Microbioleg a Geneteg, Adran Bioleg Bur a Chymhwysol, Coleg Prifysgol Cymru, Caerdydd. Prosiect Ymchwil Anrhydedd: Effaith Metel Gwenwynig a Ffactorau Allanol Eraill ar Dwf y Ffyngau Basidiomycete Hypholoma fasciculare.

Anrhydeddau a dyfarniadau

BACR Travel Award to the 7th Chinese Conference on Oncology (CCO) and The 11th Cross-Strait Academic Conference on Oncology and the China-UK-Japan Gastro-intestinal Cancer Symposium, 2012.

AACR Scholar-in Training Award, funded by Susan G. Komen for the Cure at the CTRC-AACR San Antonio Breast Cancer Symposium, Texas, December 2009 for “Evaluation of the distribution of stem cell markers in human breast cancer reveals correlation with clinical progression and metastatic disease in ductal carcinoma".

Welsh Urologists March 2006 Asware N., Martin T.A., Matthews P.N., Jiang W.G. Welsh Urologists March 2003 Brown G.M., Martin T.A., Matthews P.N., Jiang W.G. “The expression of tight junction molecules in human bladder cancer”

San Antonio Breast Cancer Symposium, December 2004 Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG. “ROCK1 and the aggressive nature of breast cancer cells”.

Welsh Urologists March 2003 Brown G.M., Martin T.A., Matthews P.N., Jiang W.G. “The expression of tight junction molecules in human bladder cancer”

Astra-Zeneca Scholar at the San Antonio Breast Cancer Symposium, December 2002 for “Expression and distribution of tight junction molecules in breast cancer and their association with clinical outcomes” and invited give an oral presentation.

AACR Scholarship April 2002 Davies G, Martin TA, Parr C, Grimshaw D, Mason MD, Jiang WG. “NK4 reduced the growth of prostate cancer in vivo”.

Certificate of Merit at the American Society of Tissue Regeneration Conference, April 2001 for Martin TA, Jiang WG, and Harding KG. Effect of human fibroblast derived dermis on human tissue expansion. American Society of Tissue Regeneration Conference.

Aelodaethau proffesiynol

American Association of Cancer Research (AACR)
Women in Cancer Research (WICR)
British Association of Cancer Research
European Association of Cancer Research

Safleoedd academaidd blaenorol

2014-present –Group Leader, Cardiff-China Medical Research Collaborative

2003 to 2014 – Lecturer, Metastasis and Angiogenesis Research Group, Cardiff University

2000-2003 Research Fellow, Metastasis and Angiogenesis Research Group, Cardiff University

1997- 2000 Research Fellow, Wound Healing Research Unit, University Department of Surgery at University of Wales College of Medicine

1996 Research Assistant, University of Wales Cardiff

Pwyllgorau ac adolygu

2004-2024 Cartref

Tîm Iechyd a Diogelwch DCAGE 2015-2020

2017-presennol Pwyllgor EDI DCG

Goruchwyliaeth ymchwil ôl-raddedig Mutli-ddisgyblaeth: PhD a MD

Myfyrwyr / Myfyrwyr presennol:

Henson Han Gao PhD (ar y cyd â Pheirianneg, Yr Athro Johannes Benedikt)

Prosiectau Ffarmacoleg, MSc a Intercalated diweddar (2024):

Chelsea Stevens
Y Dywysoges Musah Braimoh
Nikoletta Mouskoh
Weiyi Hu
Patrick Brown

Cymrodyr Ymchwil Rhyngwladol Diweddar:

Sue Xiashan Cao
Wenjing Gong
Shawn Zhang
Ling Xin
Huishan Zhao

Goruchwyliaeth gyfredol

Yufei Lou

Rhiannon Yu

Wenxiao Ji

Milad Eshmela

Amber Li

Niamh O'Neill

Cai Wang

Prosiectau'r gorffennol

Goruchwyliaeth lwyddiannus o dros 40 o brosiectau PhD, MPhil a MD.

Array

Contact Details

MartinTA1@caerdydd.ac.uk
+44 29206 87209
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Neuadd Meirionnydd, Llawr 4, Ystafell Swyddfa Ymchwil Ôl-raddedig, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS

Themâu ymchwil

Arbenigeddau

Sgrinio canser, atal a diagnosis cynnar
Bioleg celloedd canser
Clefyd metastatig
Triniaethau canser newydd

Dr Tracey Martin (hi/ei)