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Dr James McLaren
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for James McLaren
Uwch Ddarlithydd mewn Imiwnoleg
Trosolwyg
Mae fy niddordebau ymchwil yn canolbwyntio ar ddeall sut mae ymatebion imiwnedd addasol, sy'n cael eu gyrru gan gelloedd T, yn ymateb i heintiau firws a bacteria a hefyd sut mae micro-organebau pathogenig yn defnyddio strategaethau esblygol i osgoi celloedd T. Ar ben hynny, mae gen i ddiddordeb brwd mewn darganfod sut mae'r math hwn o imiwnedd cellog yn cael ei reoleiddio gan signalau biolegol (sytocinau) a sut y gall ansefydlogi pan fydd ymatebion imiwnedd byd-eang yn cael eu anghydbwyso, fel mewn sepsis.
Ar hyn o bryd rwy'n ymwneud â "Project Sepsis", cydweithrediad ymchwil ar draws disgyblaethau meddygaeth a gwyddonol sydd wedi'i sefydlu i fynd i'r afael ag angen meddygol brys am ddiagnosis cywir, cyflym sy'n canfod yr achos heintus sy'n sail i ddechrau sepsis. Yma, nod allweddol yw datgysylltu'r mecanweithiau imiwnolegol sy'n ysgogi atal imiwnedd addasol mewn sepsis gyda'r bwriad o helpu i wella diagnosis ac i lywio dyluniad ymyriadau therapiwtig newydd.
Cyhoeddiad
2025
- Davies, K. et al. 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology
2024
- Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
- Davies, K. and McLaren, J. 2024. Destabilisation of T cell-dependent humoral immunity in sepsis. Clinical Science 138(1), pp. 65-85. (10.1042/CS20230517)
2023
- Oruganti, S. et al. 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13, article number: e067002. (10.1136/bmjopen-2022-067002)
- Shepherd, F. R. et al. 2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6, article number: 78. (10.1038/s42003-023-04420-1)
2022
- Goncharov, M. et al. 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19(9), pp. 1017–1019. (10.1038/s41592-022-01578-0)
- Pymm, P. et al. 2022. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Reports 38(9), article number: 110449. (10.1016/j.celrep.2022.110449)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
2021
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Campion, S. L. et al. 2021. Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. Journal of Clinical Investigation 131(23), article number: e150823. (10.1172/JCI150823)
- Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
2020
- Narayanan, G. A. et al. 2020. The MAIT TCRβ chain contributes to discrimination of microbial ligand. Immunology and Cell Biology 98(9), pp. 770-781. (10.1111/imcb.12370)
- Shepherd, F. R. and McLaren, J. E. 2020. T cell immunity to bacterial pathogens: mechanisms of immune control and bacterial evasion. International Journal of Molecular Sciences 21(17), article number: 6144. (10.3390/ijms21176144)
- Pearson, F. E. et al. 2020. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology 9 (10.1002/cti2.1141)
- Edwards, S. C. et al. 2020. A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. Journal of Experimental Medicine 217(5), article number: e20190834. (10.1084/jem.20190834)
- Starke, C. E. et al. 2020. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. Journal of Clinical Investigation 130(2), pp. 789-798. (10.1172/JCI129161)
- Brenna, E. et al. 2020. CD4+ T follicular helper cells in human tonsils and blood are clonally convergent but divergent from Non-Tfh CD4+ cells. Cell Reports 30(1), pp. 137-152. (10.1016/j.celrep.2019.12.016)
2019
- Meckiff, B. J. et al. 2019. Primary EBV infection induces an acute wave of activated antigen-specific cytotoxic CD4+ T cells. Journal of Immunology 203(3), article number: ji1900377. (10.4049/jimmunol.1900377)
- Wong, E. B. et al. 2019. TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis. Communications Biology 2(1), pp. -., article number: 203. (10.1038/s42003-019-0442-2)
- Li, N. et al. 2019. Memory CD4+ T cells are generated in the human fetal intestine. Nature Immunology 20, pp. 301-312. (10.1038/s41590-018-0294-9)
- Mayassi, T. et al. 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176(5), pp. 967-981.e19. (10.1016/j.cell.2018.12.039)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
2018
- Pogorelyy, M. V. et al. 2018. Exploring the pre-immune landscape of antigen-specific T cells. Genome Medicine 10, article number: 68. (10.1186/s13073-018-0577-7)
- Wun, K. S. et al. 2018. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology 19, pp. 397-406. (10.1038/s41590-018-0065-7)
- Culina, S. et al. 2018. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology 3(20), article number: eaao4013. (10.1126/sciimmunol.aao4013)
- Shugay, M. et al. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46(D1), pp. D419-D427. (10.1093/nar/gkx760)
- Lissina, A. et al. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8(1), article number: 2534. (10.1038/s41598-017-18062-x)
2017
- Culshaw, A. et al. 2017. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nature Immunology 18, pp. 1228-1237. (10.1038/ni.3850)
- Davey, M. S. et al. 2017. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications 8, article number: 14760. (10.1038/ncomms14760)
- Dockree, T. et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85)
2016
- Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
- Pearson, J. A. et al. 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65(6), pp. 1679-1689. (10.2337/db15-1498)
2015
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
- Petersen, J. et al. 2015. Determinants of gliadin-specific T cell selection in celiac disease. The Journal of Immunology 194(12), pp. 6112-6122. (10.4049/jimmunol.1500161)
- Kloverpris, H. N. et al. 2015. CD8+ TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194(11), pp. 5329-5345. (10.4049/jimmunol.1400854)
- Roberto, A. et al. 2015. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125(18), pp. 2855-2864. (10.1182/blood-2014-11-608406)
- Skowera, A. et al. 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64(3), pp. 916-925. (10.2337/db14-0332)
- Costa, A. I. et al. 2015. Complex T-cell receptor repertoire dynamics underlie the CD8+T-cell response to HIV-1. Journal of Virology 89(1), pp. 110-119. (10.1128/JVI.01765-14)
2014
- Pearson, J., Thayer, T. C., McLaren, J. E., Miners, K. L., Ladell, K. I., Price, D. and Wong, F. S. 2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143(S2), pp. 152-152. (10.1111/imm.12406)
- Bengsch, B. et al. 2014. Identification of a TSCM phenotype HCV-specific CD8+T cell response with superior functionality in chronic HCV infection [Abstract]. Hepatology 60, pp. 1071A-1072A., article number: 1815.
- Kløverpris, H. N. et al. 2014. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. AIDS 28(14), pp. 2007-2021. (10.1097/QAD.0000000000000362)
- Gold, M. C. et al. 2014. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Journal of Experimental Medicine 211(8), pp. 1601-1610. (10.1084/jem.20140507)
- Davies, T. S., Li, N., McLaren, J., Hughes, T. R. and Ramji, D. P. 2014. Pro- therogenic actions of interferon-gamma on macrophages in atherosclerosis. Cardiology 128(S1), pp. 278-278. (10.1159/000365062)
- Lissina, A. et al. 2014. The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate. AIDS 28(4), pp. 477-486. (10.1097/QAD.0000000000000175)
2013
- Ladell, K. I. et al. 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38(3), pp. 425-436. (10.1016/j.immuni.2012.11.021)
2012
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42(12), pp. 3235-3242. (10.1002/eji.201242575)
- Doherty, T. M. et al. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7(10), article number: e48322. (10.1371/journal.pone.0048322)
2011
- McLaren, J. E., Michael, D. R., Guschina, I., Harwood, J. L. and Ramji, D. P. 2011. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46(11), pp. 1053-1061.
- Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
- McLaren, J. E., Michael, D. R., Ashlin, T. G. and Ramji, D. P. 2011. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Progress in Lipid Research 50(4), pp. 331-347. (10.1016/j.plipres.2011.04.002)
2010
- Li, N., McLaren, J. E., Michael, D. R., Clement, M., Fielding, C. A. and Ramji, D. P. 2010. ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. The Journal of Immunology 185(5), pp. 3041-3048. (10.4049/jimmunol.1000993)
- McLaren, J. E. et al. 2010. IL-33 reduces macrophage foam cell formation. The Journal of Immunology 185(2), pp. 1222-1229. (10.4049/jimmunol.1000520)
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
2009
- McLaren, J. E., Zuo, J., Grimstead, J. W., Poghosyan, Z., Bell, A. I., Rowe, M. and Brennan, P. 2009. STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells. Journal of General Virology 90(9), pp. 2239-2250. (10.1099/vir.0.011627-0)
- McLaren, J. E. and Ramji, D. P. 2009. Interferon gamma: A master regulator of atherosclerosis. Cytokine & Growth Factor Reviews 20(2), pp. 125-135. (10.1016/j.cytogfr.2008.11.003)
2007
- McLaren, J. E., Rowe, M. and Brennan, P. 2007. Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes. Journal of General Virology 88(7), pp. 1876-1886. (10.1099/vir.0.82741-0)
- McLaren, J. E. 2007. Regulation of the STAT1 by the Epstein-Barr virus.. PhD Thesis, Cardiff University.
2006
- White, P. C., Shore, A. M., Clement, M., McLaren, J. E., Soeiro, I., Lam, E. W. and Brennan, P. 2006. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25(15), pp. 2170-2180. (10.1038/sj.onc.1209255)
Articles
- Davies, K. et al. 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology
- Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
- Davies, K. and McLaren, J. 2024. Destabilisation of T cell-dependent humoral immunity in sepsis. Clinical Science 138(1), pp. 65-85. (10.1042/CS20230517)
- Oruganti, S. et al. 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13, article number: e067002. (10.1136/bmjopen-2022-067002)
- Shepherd, F. R. et al. 2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6, article number: 78. (10.1038/s42003-023-04420-1)
- Goncharov, M. et al. 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19(9), pp. 1017–1019. (10.1038/s41592-022-01578-0)
- Pymm, P. et al. 2022. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Reports 38(9), article number: 110449. (10.1016/j.celrep.2022.110449)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Campion, S. L. et al. 2021. Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. Journal of Clinical Investigation 131(23), article number: e150823. (10.1172/JCI150823)
- Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
- Narayanan, G. A. et al. 2020. The MAIT TCRβ chain contributes to discrimination of microbial ligand. Immunology and Cell Biology 98(9), pp. 770-781. (10.1111/imcb.12370)
- Shepherd, F. R. and McLaren, J. E. 2020. T cell immunity to bacterial pathogens: mechanisms of immune control and bacterial evasion. International Journal of Molecular Sciences 21(17), article number: 6144. (10.3390/ijms21176144)
- Pearson, F. E. et al. 2020. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology 9 (10.1002/cti2.1141)
- Edwards, S. C. et al. 2020. A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. Journal of Experimental Medicine 217(5), article number: e20190834. (10.1084/jem.20190834)
- Starke, C. E. et al. 2020. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. Journal of Clinical Investigation 130(2), pp. 789-798. (10.1172/JCI129161)
- Brenna, E. et al. 2020. CD4+ T follicular helper cells in human tonsils and blood are clonally convergent but divergent from Non-Tfh CD4+ cells. Cell Reports 30(1), pp. 137-152. (10.1016/j.celrep.2019.12.016)
- Meckiff, B. J. et al. 2019. Primary EBV infection induces an acute wave of activated antigen-specific cytotoxic CD4+ T cells. Journal of Immunology 203(3), article number: ji1900377. (10.4049/jimmunol.1900377)
- Wong, E. B. et al. 2019. TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis. Communications Biology 2(1), pp. -., article number: 203. (10.1038/s42003-019-0442-2)
- Li, N. et al. 2019. Memory CD4+ T cells are generated in the human fetal intestine. Nature Immunology 20, pp. 301-312. (10.1038/s41590-018-0294-9)
- Mayassi, T. et al. 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176(5), pp. 967-981.e19. (10.1016/j.cell.2018.12.039)
- McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
- Pogorelyy, M. V. et al. 2018. Exploring the pre-immune landscape of antigen-specific T cells. Genome Medicine 10, article number: 68. (10.1186/s13073-018-0577-7)
- Wun, K. S. et al. 2018. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology 19, pp. 397-406. (10.1038/s41590-018-0065-7)
- Culina, S. et al. 2018. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology 3(20), article number: eaao4013. (10.1126/sciimmunol.aao4013)
- Shugay, M. et al. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46(D1), pp. D419-D427. (10.1093/nar/gkx760)
- Lissina, A. et al. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8(1), article number: 2534. (10.1038/s41598-017-18062-x)
- Culshaw, A. et al. 2017. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nature Immunology 18, pp. 1228-1237. (10.1038/ni.3850)
- Davey, M. S. et al. 2017. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications 8, article number: 14760. (10.1038/ncomms14760)
- Dockree, T. et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85)
- Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
- Pearson, J. A. et al. 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65(6), pp. 1679-1689. (10.2337/db15-1498)
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
- Petersen, J. et al. 2015. Determinants of gliadin-specific T cell selection in celiac disease. The Journal of Immunology 194(12), pp. 6112-6122. (10.4049/jimmunol.1500161)
- Kloverpris, H. N. et al. 2015. CD8+ TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194(11), pp. 5329-5345. (10.4049/jimmunol.1400854)
- Roberto, A. et al. 2015. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125(18), pp. 2855-2864. (10.1182/blood-2014-11-608406)
- Skowera, A. et al. 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64(3), pp. 916-925. (10.2337/db14-0332)
- Costa, A. I. et al. 2015. Complex T-cell receptor repertoire dynamics underlie the CD8+T-cell response to HIV-1. Journal of Virology 89(1), pp. 110-119. (10.1128/JVI.01765-14)
- Pearson, J., Thayer, T. C., McLaren, J. E., Miners, K. L., Ladell, K. I., Price, D. and Wong, F. S. 2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143(S2), pp. 152-152. (10.1111/imm.12406)
- Bengsch, B. et al. 2014. Identification of a TSCM phenotype HCV-specific CD8+T cell response with superior functionality in chronic HCV infection [Abstract]. Hepatology 60, pp. 1071A-1072A., article number: 1815.
- Kløverpris, H. N. et al. 2014. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. AIDS 28(14), pp. 2007-2021. (10.1097/QAD.0000000000000362)
- Gold, M. C. et al. 2014. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Journal of Experimental Medicine 211(8), pp. 1601-1610. (10.1084/jem.20140507)
- Davies, T. S., Li, N., McLaren, J., Hughes, T. R. and Ramji, D. P. 2014. Pro- therogenic actions of interferon-gamma on macrophages in atherosclerosis. Cardiology 128(S1), pp. 278-278. (10.1159/000365062)
- Lissina, A. et al. 2014. The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate. AIDS 28(4), pp. 477-486. (10.1097/QAD.0000000000000175)
- Ladell, K. I. et al. 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38(3), pp. 425-436. (10.1016/j.immuni.2012.11.021)
- Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42(12), pp. 3235-3242. (10.1002/eji.201242575)
- Doherty, T. M. et al. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7(10), article number: e48322. (10.1371/journal.pone.0048322)
- McLaren, J. E., Michael, D. R., Guschina, I., Harwood, J. L. and Ramji, D. P. 2011. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46(11), pp. 1053-1061.
- Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
- McLaren, J. E., Michael, D. R., Ashlin, T. G. and Ramji, D. P. 2011. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Progress in Lipid Research 50(4), pp. 331-347. (10.1016/j.plipres.2011.04.002)
- Li, N., McLaren, J. E., Michael, D. R., Clement, M., Fielding, C. A. and Ramji, D. P. 2010. ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. The Journal of Immunology 185(5), pp. 3041-3048. (10.4049/jimmunol.1000993)
- McLaren, J. E. et al. 2010. IL-33 reduces macrophage foam cell formation. The Journal of Immunology 185(2), pp. 1222-1229. (10.4049/jimmunol.1000520)
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
- McLaren, J. E., Zuo, J., Grimstead, J. W., Poghosyan, Z., Bell, A. I., Rowe, M. and Brennan, P. 2009. STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells. Journal of General Virology 90(9), pp. 2239-2250. (10.1099/vir.0.011627-0)
- McLaren, J. E. and Ramji, D. P. 2009. Interferon gamma: A master regulator of atherosclerosis. Cytokine & Growth Factor Reviews 20(2), pp. 125-135. (10.1016/j.cytogfr.2008.11.003)
- McLaren, J. E., Rowe, M. and Brennan, P. 2007. Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes. Journal of General Virology 88(7), pp. 1876-1886. (10.1099/vir.0.82741-0)
- White, P. C., Shore, A. M., Clement, M., McLaren, J. E., Soeiro, I., Lam, E. W. and Brennan, P. 2006. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25(15), pp. 2170-2180. (10.1038/sj.onc.1209255)
Thesis
- McLaren, J. E. 2007. Regulation of the STAT1 by the Epstein-Barr virus.. PhD Thesis, Cardiff University.
- Shepherd, F. R. et al. 2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6, article number: 78. (10.1038/s42003-023-04420-1)
Addysgu
Addysgu:
- MET921 - MSc Imiwnoleg Glinigol Gymhwysol ac Arbrofol
- Gradd MBBCh SSC Blwyddyn 2: Imiwnoleg Ryngweithiol a Chlefydau Heintus - Darlithydd a chyfrannwr ymarferol
- Gradd MBBCh SSC Blwyddyn 1: Adolygiad Llenyddiaeth
- Llwyfan gradd MBBCh Blwyddyn 1 ar gyfer Gwyddoniaeth Glinigol (PCS): Imiwnoleg Gymhwysol - Tiwtor Academaidd
- Tiwtor personol gradd MBBCh
Gwerthuso'r myfyrwyr:
- Arfarnwr Myfyrwyr PhD a Chadeirydd Panel
- PhD ac MSc arholwr myfyrwyr
Bywgraffiad
Dechreuodd fy ngyrfa ymchwil yn 2004 gyda Ph.D. yn labordy yr Athro Martin Rowe a Dr Paul Brennan ym Mhrifysgol Caerdydd. Yn ystod y cyfnod hwn, canolbwyntiodd fy ymchwil ar ddyrannu sut mae Firws Epstein-Barr (EBV) yn rheoleiddio mecanweithiau gwrthfeirysol allweddol (signalau interferon) yn ystod trawsnewidiad celloedd-B. Sbardunodd yr ymchwil hon fy niddordeb mewn modiwleiddio cytokine imiwnedd addasol. O'r fan hon, ymgymerais â'm swydd ôl-ddoethurol gyntaf, dan oruchwyliaeth Dr Dipak Ramji ym Mhrifysgol Caerdydd, lle astudiais sut y mae cytocinau yn trin ffurfio celloedd ewyn sy'n deillio o facroffagau. Mae ffurfio celloedd ewyn yn broses allweddol ym pathogenesis atherosclerosis a chlefyd y galon a phenderfynais y gallai interleukin-33 (IL-33) atal ffurfio celloedd ewyn macrophage, a oedd yn ddarganfyddiad newydd ar y pryd.
Yn 2010, dyfarnwyd Cymrodoriaeth Gwerth Ymddiriedolaeth Wellcome mewn Pobl (VIP) i ymuno â labordy yr Athro David Price ym Mhrifysgol Caerdydd i ehangu fy niddordebau mewn imiwnoleg firaol a bioleg cytokine. Yma, canolbwyntiais ar berfformio dulliau uwch-dechnoleg (cytometreg llif polychromatig, dilyniant derbynnydd celloedd T uwch) i ddeall sut mae ymatebion imiwn celloedd T sy'n benodol i antigen-benodol yn cael eu defnyddio mewn bodau dynol a llygod yn ystod firws (HIV, cytomegalofirws, EBV, firws dengue), coloneiddio microbaidd, llid a chlefyd. Yn ystod y gymrodoriaeth hon a thu hwnt (2010-2018), rwyf wedi gwneud rhai cyfraniadau sylweddol i'r maes imiwnolegol, gan gynnwys nifer o gyhoeddiadau effaith uchel (Cell, Imiwnoleg Natur, Imiwnoleg Gwyddoniaeth, Imiwnedd, Journal of Experimental Medicine), ac rwyf wedi cael gwahoddiad i roi darlithoedd ar yr ymchwil hon mewn cynadleddau, cwmnïau biotechnoleg a sefydliadau academaidd yn y DU ac Awstralia. Yn ogystal, ehangais fy niddordebau mewn cytocinau (ee IL-33) trwy archwilio sut maent yn rheoleiddio imiwnedd celloedd T yn ystod haint firws yn vivo.
Yn 2018, cefais fy recriwtio fel Darlithydd mewn Imiwnedd Systemau ym Mhrifysgol Caerdydd i gymhwyso fy arbenigedd mewn proffilio celloedd T yn ystod yr haint ar gyfer "Project Sepsis", cydweithrediad ymchwil newydd a sefydlwyd i fynd i'r afael ag angen meddygol brys i roi diagnosis cywir o sepsis ac i ddatblygu ymyriadau therapiwtig newydd. Yn 2023, cefais fy nyrchafu i Uwch-ddarlithydd ac mae fy niddordebau ymchwil ar hyn o bryd yn canolbwyntio ar ddeall sut mae celloedd T yn ymateb i heintiau bacteriol a firaol a hefyd sut mae'r organebau mircro-organebau hyn yn defnyddio strategaethau i osgoi celloedd T
Anrhydeddau a dyfarniadau
- Grant Cronfa Deithio Rutherford Prifysgol Caerdydd (2018)
- Gwobr Teithio Cymdeithas Imiwnoleg Prydain – 41ain Gweithfan Rhyngwladol Rhyngwladol Herpesvirus, Madison, WI, UDA (2016)
- Gwobr Cronfa Morgan E Williams Prifysgol Caerdydd (2016)
- Gwobr Cronfa WM Thomas Prifysgol Caerdydd (2016)
- Gwobr 1af am y cyflwyniad gorau yng nghyfarfod blynyddol I3-IRG Prifysgol Caerdydd (2007)
- Cymrodoriaeth Teithio - 12fed cynhadledd ddwyflynyddol y Gymdeithas Ryngwladol ar gyfer Ymchwil ar Firws Epstein-Barr a Chlefydau Cysylltiedig, Boston, MA, UDA (2006)
Aelodaethau proffesiynol
- Aelod o Gymdeithas Imiwnoleg Prydain
Safleoedd academaidd blaenorol
- 2023-presennol: Uwch Ddarlithydd mewn Imiwnoleg, Is-adran Heintiau ac Imiwnedd, Prifysgol Caerdydd, y DU
- 2018-2023: Darlithydd mewn Imiwnedd Systemau, Is-adran Heintiau ac Imiwnedd, Prifysgol Caerdydd, UK
- 2011-2018: Cydymaith Ymchwil, Is-adran Heintiau ac Imiwnedd, Prifysgol Caerdydd, y DU
- 2014: Ysgolhaig Ymweld, Canolfan Ymchwil Brechlynnau, NIAID, NIH, Bethesda, MD 20982, UDA
- 2010-2011: Cymrawd Ymchwil Gwerth mewn Pobl Ymddiriedolaeth Wellcome, Prifysgol Caerdydd, UK
- 2007-2010: British Heart Foundation Research Associate, Ysgol y Biowyddorau, Prifysgol Caerdydd, UK
Pwyllgorau ac adolygu
Pwyllgorau ac adolygu grant:
- Adolygydd grant, Cyngor Ymchwil Meddygol
- Adolygydd grant, Academi Gwyddorau Meddygol
- Adolygydd y grant, Agence Nationale de la Recherche (Ffrainc)
- Adolygydd grant, Sefydliad Gwyddoniaeth Cenedlaethol y Swistir
- Panel grant, Ymddiriedolaeth Wellcome/ISSF Prifysgol Caerdydd
- Adolygydd / panel grant, Cyfrif Cyflymu Effaith Cysoni UKRI
- Panel Arbenigol ECR. Oxford Open Immunology
Adolygiad cyfnodolyn:
- Adolygydd cyfnodolyn, Advanced Science
- Journal Reviewer, European Journal of Immunology
- Adolygydd cyfnodolyn, Frontiers in Immunology
- Adolygydd cyfnodolyn, Frontiers in Virology
- Adolygydd Cyfnodolion, iScience
- Journal Reviewer, International Journal of Molecular Sciences
- Journal Reviewer, Journal of Immunology
- Adolygydd cyfnodolyn, Lancet EBioMedicine
- Adolygydd Cyfnodolion, Cyfathrebu Natur
Bwrdd golygyddol:
- Adran Olygydd, Journal of Immunology
- Bwrdd golygyddol, Frontiers in Genetics
- Bwrdd golygyddol, Frontiers in Medicine
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PhD sydd â diddordeb cryf mewn imiwnoleg celloedd T ym meysydd:
- Imiwnedd celloedd T sy'n benodol i firws
- Imiwnedd celloedd T sy'n cael ei yrru gan facteria
- modulation sy'n cael ei yrru gan cytokine imiwnedd addasol
- Mecanweithiau atal imiwnedd yn ystod sepsis
Goruchwyliaeth gyfredol
Kate Davies
Prosiectau'r gorffennol
- Katherine Stanswood (2022) - MSc Imiwnoleg Glinigol Gymhwysol ac Arbrofol (prosiect traethawd hir) - "Mecanweithiau imiwnoteipio camweithrediad celloedd T yn ystod dyfodiad sepsis"
- Annie Bird (2022) - MSc Biowybodeg (prosiect traethawd hir) - "Chwyldroi ffenoteipio cellog: Proffilio trawsgrifiad a phroteipio protein gan ddefnyddio dilyniannu aml-omeg un gell"
- Lucy Sheikh (2023) - Prosiect traethawd hir MSc Imiwnoleg Glinigol Gymhwysol ac Arbrofol - "imiwnedd celloedd T gwrthficrobaidd camweithredol imiwnoteipio yn ystod sepsis"
Ymgysylltu
- Cyfrannwr gweithredol at Wyddoniaeth mewn Iechyd Prifysgol Caerdydd: Wythnos fyw
- Cyfrannwr at Brosiect Allgymorth Rhwydwaith Cymdeithas Ddysgedig Cymru a Seren 2018
Contact Details
McLarenJE@caerdydd.ac.uk
+44 29207 44431
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell 2/04, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
+44 29207 44431
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell 2/04, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Imiwnoleg
- Imiwnoleg cellog
- Afiechydon heintus
- Imiwnedd celloedd T
