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Trosolwyg
Rwy'n Academydd Clinigol mewn Neffroleg ac yn Bennaeth Labordai Uned Ymchwil Aren Cymru yng Nghaerdydd. Mae gen i swydd Uwch-ddarlithydd Clinigol yn yr Ysgol Meddygaeth ym Mhrifysgol Caerdydd ac mae gennyf swydd Neffroleg Ymgynghorol er Anrhydedd ym Mwrdd Iechyd Caerdydd a'r Fro a Bwrdd Iechyd Aneurin Bevan.
Fy mhrif ddiddordebau ymchwil yw ym maes ffibrosis arennol. Nod fy grŵp yw deall a disgrifio'r mecanweithiau a all atal a/neu wrthdroi anaf acíwt a blaengar i'r arennau gan arwain at well iechyd yr arennau. Mae'r matrics allgellog yn chwarae rhan bwysig wrth gynnal iechyd biolegol yn ein celloedd a'n meinweoedd ac mae rheoleiddio matrics allgellog aberrant yn gyrru afiechyd, yn enwedig yn yr arennau. Mae fy ymchwil wedi dangos bod Hyaluronan yn glycosaminoglycans matrics allgellog, sy'n bwysig wrth reoleiddio ffenoteip celloedd stromal a swyddogaeth i ddylanwadu ar iechyd a chlefyd arennol. Mae fy astudiaethau'n canolbwyntio ar sut y gellir rheoleiddio'r gydran matrics hon i wella adferiad arennau yn dilyn anaf a chlefyd.
Mae fy meysydd ymchwil cyfochrog yn cynnwys ymchwil dialysis peritoneol (deall mecanweithiau sy'n gyrru ffibrosis yn y peritonewm) ac ymchwil cardiofasgwlaidd (deall gyrwyr cellog a moleciwlaidd mwy o batholeg cardiofasgwlaidd mewn cleifion â chlefyd yr arennau).
Mae gen i ddiddordeb sylweddol mewn addysg feddygol israddedig ac ôl-raddedig ac mae gen i swyddi addysgu arweiniol yn y ddau faes hyn. Roeddwn hefyd yn rhan o raglen SUSTAIN yr Academi Gwyddorau Meddygol pan gafodd ei sefydlu gyntaf yn 2015.
Cyhoeddiad
2024
- Smith, T. et al. 2024. Robust rat and mouse models of bilateral renal ischemia reperfusion injury. In Vivo 38(3), pp. 1049-1057. (10.21873/invivo.13538)
- Brown, C. V. M. et al. 2024. Protective effect of ischaemic preconditioning on acute and chronic renal damage following ischaemia reperfusion injury: characterisation of fibrosis development after inflammation resolution. International Journal of Clinical and Experimental Pathology 17(4), pp. 151-164. (10.62347/MFJG1164)
2023
- Cetin, E. et al. 2023. Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection. Frontiers in Cellular and Infection Microbiology 13, article number: 1285193. (10.3389/fcimb.2023.1285193)
- Grigorieva, I., Woods, E. L., Steadman, R., Bowen, T. and Meran, S. 2023. Hyaluronan in kidney fibrosis. In: Passi, A. ed. Hyaluronan: Structure, Biology and Biotechnology., Vol. 14. Biology of Extracellular Matrix Springer, pp. 77-97., (10.1007/978-3-031-30300-5_5)
2021
- Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297(3), article number: 100987. (10.1016/j.jbc.2021.100987)
2020
- Midgley, A. C. et al. 2020. Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions. American Journal of Pathology 190(6), pp. 1236-1255. (10.1016/j.ajpath.2020.02.012)
2018
- Huang, D. et al. 2018. Cordyceps Sinensis: anti-fibrotic and inflammatory effects of a cultured polysaccharide extract. Bioactive Carbohydrates and Dietary Fibre 14, pp. 2-8. (10.1016/j.bcdf.2017.07.012)
2017
- Midgley, A. C., Oltean, S., Hascall, V., Woods, E. L., Steadman, R., Phillips, A. O. and Meran, S. 2017. Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype. Science Signaling 10(506), article number: eaao1822. (10.1126/scisignal.aao1822)
2016
- Johnson, F., Phillips, D., Talabani, B., Wonnacott, A., Meran, S. and Phillips, A. 2016. The impact of acute kidney injury in diabetes mellitus. Journal of Thrombosis and Haemostatis 21(6), pp. 506-511. (10.1111/nep.12649)
- Martin, J., Midgley, A., Meran, S., Woods, E., Bowen, T., Phillips, A. O. and Steadman, R. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291, pp. 13789-13801. (10.1074/jbc.M115.670521)
2015
- Midgley, A. C., Druggal, L., Jenkins, R., Hascall, V., Steadman, R., Phillips, A. O. and Meran, S. 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. Journal of Biological Chemistry 290(18), pp. 11218-11234. (10.1074/jbc.M114.625939)
- Bowen, T., Meran, S., Williams, A., Newbury, L., Sauter, M. and Sitter, T. 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015, article number: 427038. (10.1155/2015/427038)
2014
- Wonnacott, A., Meran, S., Amphlett, B., Talabani, B. and Phillips, A. 2014. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clinical Journal of the American Society of Nephrology 9(6), pp. 1007-1014. (10.2215/CJN.07920713)
- Talabani, B., Zouwail, S., Pyart, R., Meran, S., Riley, S. and Phillips, A. 2014. Epidemiology and outcome of community-acquired acute kidney injury. Nephrology 19(5), pp. 282-287. (10.1111/nep.12221)
- Yao, X. et al. 2014. Cordyceps sinensis: in vitro anti-fibrotic bioactivity of natural and cultured preparations. Food Hydrocolloids 35, pp. 444-452. (10.1016/j.foodhyd.2013.06.023)
- Meran, S., Wonnacott, A., Amphlett, B. and Phillips, A. 2014. How good are we at managing acute kidney injury in hospital?. Clinical Kidney Journal 7(2), pp. 144-150. (10.1093/ckj/sfu010)
- Phillips, L., Phillips, B., Meran, S., Russell, J., Zouwail, S., Riley, S. and Phillips, A. 2014. The long-term impact of eGFR reporting on referral patterns. European Journal of Internal Medicine 25(1), pp. 97-101. (10.1016/j.ejim.2013.08.001)
2013
- Meran, S., Martin, J., Luo, D. D., Steadman, R. and Phillips, A. O. 2013. Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding. American Journal of Pathology 182(6), pp. 2223-2240. (10.1016/j.ajpath.2013.02.038)
2012
- Wonnacott, A., Meran, S., Roberts, G. W., Donovan, K., Riley, S. G. and Phillips, A. O. 2012. Applying estimated glomerular filtration rate to an ageing population: are we in danger of becoming ageist?. European Journal of Internal Medicine 23(8), pp. 705-710. (10.1016/j.ejim.2012.08.012)
2011
- Bommayya, G., Meran, S., Krupa, A., Phillips, A. O. and Steadman, R. 2011. Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial–mesenchymal transition of proximal tubular epithelial cells. International Journal of Biochemistry & Cell Biology 43(12), pp. 1739-1746. (10.1016/j.biocel.2011.08.009)
- Meran, S., Luo, D. D., Simpson, R. M. L., Martin, J., Wells, A., Steadman, R. and Phillips, A. O. 2011. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Journal of Biological Chemistry 286(20), pp. 17618-17630. (10.1074/jbc.M111.226563)
- Meran, S. and Steadman, R. 2011. Fibroblasts and myofibroblasts in renal fibrosis. International Journal of Experimental Pathology 92(3), pp. 158-167. (10.1111/j.1365-2613.2011.00764.x)
2010
- Meran, S., Don, K., Shah, N., Donovan, K., Riley, S. G. and Phillips, A. O. 2010. Impact of chronic kidney disease management in primary care. QJM 104(1), pp. 27-34. (10.1093/qjmed/hcq151)
2009
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Webber, J. P., Jenkins, R. H., Meran, S., Phillips, A. O. and Steadman, R. 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175(1), pp. 148-160. (10.2353/ajpath.2009.080837)
- Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Hyaluronan orchestrates transforming growth factor-β1-dependent maintenance of myofibroblast phenotype. Journal of Biological Chemistry 284(14), pp. 9083-9092. (10.1074/jbc.M806989200)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
2008
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
2007
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
Adrannau llyfrau
- Grigorieva, I., Woods, E. L., Steadman, R., Bowen, T. and Meran, S. 2023. Hyaluronan in kidney fibrosis. In: Passi, A. ed. Hyaluronan: Structure, Biology and Biotechnology., Vol. 14. Biology of Extracellular Matrix Springer, pp. 77-97., (10.1007/978-3-031-30300-5_5)
Erthyglau
- Smith, T. et al. 2024. Robust rat and mouse models of bilateral renal ischemia reperfusion injury. In Vivo 38(3), pp. 1049-1057. (10.21873/invivo.13538)
- Brown, C. V. M. et al. 2024. Protective effect of ischaemic preconditioning on acute and chronic renal damage following ischaemia reperfusion injury: characterisation of fibrosis development after inflammation resolution. International Journal of Clinical and Experimental Pathology 17(4), pp. 151-164. (10.62347/MFJG1164)
- Cetin, E. et al. 2023. Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection. Frontiers in Cellular and Infection Microbiology 13, article number: 1285193. (10.3389/fcimb.2023.1285193)
- Woods, E. L. et al. 2021. CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β1. Journal of Biological Chemistry 297(3), article number: 100987. (10.1016/j.jbc.2021.100987)
- Midgley, A. C. et al. 2020. Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions. American Journal of Pathology 190(6), pp. 1236-1255. (10.1016/j.ajpath.2020.02.012)
- Huang, D. et al. 2018. Cordyceps Sinensis: anti-fibrotic and inflammatory effects of a cultured polysaccharide extract. Bioactive Carbohydrates and Dietary Fibre 14, pp. 2-8. (10.1016/j.bcdf.2017.07.012)
- Midgley, A. C., Oltean, S., Hascall, V., Woods, E. L., Steadman, R., Phillips, A. O. and Meran, S. 2017. Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype. Science Signaling 10(506), article number: eaao1822. (10.1126/scisignal.aao1822)
- Johnson, F., Phillips, D., Talabani, B., Wonnacott, A., Meran, S. and Phillips, A. 2016. The impact of acute kidney injury in diabetes mellitus. Journal of Thrombosis and Haemostatis 21(6), pp. 506-511. (10.1111/nep.12649)
- Martin, J., Midgley, A., Meran, S., Woods, E., Bowen, T., Phillips, A. O. and Steadman, R. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291, pp. 13789-13801. (10.1074/jbc.M115.670521)
- Midgley, A. C., Druggal, L., Jenkins, R., Hascall, V., Steadman, R., Phillips, A. O. and Meran, S. 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. Journal of Biological Chemistry 290(18), pp. 11218-11234. (10.1074/jbc.M114.625939)
- Bowen, T., Meran, S., Williams, A., Newbury, L., Sauter, M. and Sitter, T. 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015, article number: 427038. (10.1155/2015/427038)
- Wonnacott, A., Meran, S., Amphlett, B., Talabani, B. and Phillips, A. 2014. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clinical Journal of the American Society of Nephrology 9(6), pp. 1007-1014. (10.2215/CJN.07920713)
- Talabani, B., Zouwail, S., Pyart, R., Meran, S., Riley, S. and Phillips, A. 2014. Epidemiology and outcome of community-acquired acute kidney injury. Nephrology 19(5), pp. 282-287. (10.1111/nep.12221)
- Yao, X. et al. 2014. Cordyceps sinensis: in vitro anti-fibrotic bioactivity of natural and cultured preparations. Food Hydrocolloids 35, pp. 444-452. (10.1016/j.foodhyd.2013.06.023)
- Meran, S., Wonnacott, A., Amphlett, B. and Phillips, A. 2014. How good are we at managing acute kidney injury in hospital?. Clinical Kidney Journal 7(2), pp. 144-150. (10.1093/ckj/sfu010)
- Phillips, L., Phillips, B., Meran, S., Russell, J., Zouwail, S., Riley, S. and Phillips, A. 2014. The long-term impact of eGFR reporting on referral patterns. European Journal of Internal Medicine 25(1), pp. 97-101. (10.1016/j.ejim.2013.08.001)
- Meran, S., Martin, J., Luo, D. D., Steadman, R. and Phillips, A. O. 2013. Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding. American Journal of Pathology 182(6), pp. 2223-2240. (10.1016/j.ajpath.2013.02.038)
- Wonnacott, A., Meran, S., Roberts, G. W., Donovan, K., Riley, S. G. and Phillips, A. O. 2012. Applying estimated glomerular filtration rate to an ageing population: are we in danger of becoming ageist?. European Journal of Internal Medicine 23(8), pp. 705-710. (10.1016/j.ejim.2012.08.012)
- Bommayya, G., Meran, S., Krupa, A., Phillips, A. O. and Steadman, R. 2011. Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial–mesenchymal transition of proximal tubular epithelial cells. International Journal of Biochemistry & Cell Biology 43(12), pp. 1739-1746. (10.1016/j.biocel.2011.08.009)
- Meran, S., Luo, D. D., Simpson, R. M. L., Martin, J., Wells, A., Steadman, R. and Phillips, A. O. 2011. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Journal of Biological Chemistry 286(20), pp. 17618-17630. (10.1074/jbc.M111.226563)
- Meran, S. and Steadman, R. 2011. Fibroblasts and myofibroblasts in renal fibrosis. International Journal of Experimental Pathology 92(3), pp. 158-167. (10.1111/j.1365-2613.2011.00764.x)
- Meran, S., Don, K., Shah, N., Donovan, K., Riley, S. G. and Phillips, A. O. 2010. Impact of chronic kidney disease management in primary care. QJM 104(1), pp. 27-34. (10.1093/qjmed/hcq151)
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Webber, J. P., Jenkins, R. H., Meran, S., Phillips, A. O. and Steadman, R. 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175(1), pp. 148-160. (10.2353/ajpath.2009.080837)
- Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Hyaluronan orchestrates transforming growth factor-β1-dependent maintenance of myofibroblast phenotype. Journal of Biological Chemistry 284(14), pp. 9083-9092. (10.1074/jbc.M806989200)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Johnson, F., Phillips, D., Talabani, B., Wonnacott, A., Meran, S. and Phillips, A. 2016. The impact of acute kidney injury in diabetes mellitus. Journal of Thrombosis and Haemostatis 21(6), pp. 506-511. (10.1111/nep.12649)
- Martin, J., Midgley, A., Meran, S., Woods, E., Bowen, T., Phillips, A. O. and Steadman, R. 2016. Tumour necrosis factor-stimulated gene (TSG)-6-mediated interactions with the inter-alpha-inhibitor heavy chain 5 facilitate TGF beta1-dependent fibroblast to myofibroblast differentiation.. Journal of Biological Chemistry 291, pp. 13789-13801. (10.1074/jbc.M115.670521)
- Midgley, A. C., Druggal, L., Jenkins, R., Hascall, V., Steadman, R., Phillips, A. O. and Meran, S. 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. Journal of Biological Chemistry 290(18), pp. 11218-11234. (10.1074/jbc.M114.625939)
- Bowen, T., Meran, S., Williams, A., Newbury, L., Sauter, M. and Sitter, T. 2015. Regulation of synthesis and roles of hyaluronan in peritoneal dialysis. BioMed Research International 2015, article number: 427038. (10.1155/2015/427038)
- Wonnacott, A., Meran, S., Amphlett, B., Talabani, B. and Phillips, A. 2014. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clinical Journal of the American Society of Nephrology 9(6), pp. 1007-1014. (10.2215/CJN.07920713)
- Talabani, B., Zouwail, S., Pyart, R., Meran, S., Riley, S. and Phillips, A. 2014. Epidemiology and outcome of community-acquired acute kidney injury. Nephrology 19(5), pp. 282-287. (10.1111/nep.12221)
- Yao, X. et al. 2014. Cordyceps sinensis: in vitro anti-fibrotic bioactivity of natural and cultured preparations. Food Hydrocolloids 35, pp. 444-452. (10.1016/j.foodhyd.2013.06.023)
- Meran, S., Wonnacott, A., Amphlett, B. and Phillips, A. 2014. How good are we at managing acute kidney injury in hospital?. Clinical Kidney Journal 7(2), pp. 144-150. (10.1093/ckj/sfu010)
- Meran, S., Martin, J., Luo, D. D., Steadman, R. and Phillips, A. O. 2013. Interleukin-1β induces hyaluronan and CD44-dependent cell protrusions that facilitate fibroblast-monocyte binding. American Journal of Pathology 182(6), pp. 2223-2240. (10.1016/j.ajpath.2013.02.038)
- Wonnacott, A., Meran, S., Roberts, G. W., Donovan, K., Riley, S. G. and Phillips, A. O. 2012. Applying estimated glomerular filtration rate to an ageing population: are we in danger of becoming ageist?. European Journal of Internal Medicine 23(8), pp. 705-710. (10.1016/j.ejim.2012.08.012)
- Bommayya, G., Meran, S., Krupa, A., Phillips, A. O. and Steadman, R. 2011. Tumour necrosis factor-stimulated gene (TSG)-6 controls epithelial–mesenchymal transition of proximal tubular epithelial cells. International Journal of Biochemistry & Cell Biology 43(12), pp. 1739-1746. (10.1016/j.biocel.2011.08.009)
- Meran, S., Luo, D. D., Simpson, R. M. L., Martin, J., Wells, A., Steadman, R. and Phillips, A. O. 2011. Hyaluronan facilitates transforming growth factor-β1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. Journal of Biological Chemistry 286(20), pp. 17618-17630. (10.1074/jbc.M111.226563)
- Meran, S. and Steadman, R. 2011. Fibroblasts and myofibroblasts in renal fibrosis. International Journal of Experimental Pathology 92(3), pp. 158-167. (10.1111/j.1365-2613.2011.00764.x)
- Meran, S., Don, K., Shah, N., Donovan, K., Riley, S. G. and Phillips, A. O. 2010. Impact of chronic kidney disease management in primary care. QJM 104(1), pp. 27-34. (10.1093/qjmed/hcq151)
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Webber, J. P., Jenkins, R. H., Meran, S., Phillips, A. O. and Steadman, R. 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175(1), pp. 148-160. (10.2353/ajpath.2009.080837)
- Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Hyaluronan orchestrates transforming growth factor-β1-dependent maintenance of myofibroblast phenotype. Journal of Biological Chemistry 284(14), pp. 9083-9092. (10.1074/jbc.M806989200)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
Ymchwil
Maes Ymchwil Sylfaenol
Mae fy ymchwil wedi canolbwyntio ar fioleg celloedd a matrics fel y'i cymhwysir at glefyd arennol cynyddol. Mae gan 15% o boblogaeth y DU glefyd cronig yr arennau, gan eu rhoi mewn mwy o berygl o amlafiachedd a marwolaeth. Nid yw atal/gwrthdroi prosesau ffibr-amlochrog sylfaenol sy'n gyrru clefyd cronig yr arennau yn bosibl eto, ac mae ymarfer clinigol cyfredol yn rhagweld yn wael a fydd cleifion yn datblygu clefyd cronig yr arennau blaengar neu'n dangos adferiad arennol a/neu ddatrysiad. Nod fy ngrŵp yw nodi targedau moleciwlaidd a chellol newydd a all atal clefyd acíwt a chronig yr arennau i atal cleifion sydd angen therapïau amnewid arennol.
Mae Hyaluronan yn glycosaminoglycans matrics sy'n dangos mwy o fynegiant strymol ym mhob math o anaf acíwt a chronig i'r arennau, gyda'i fynegiant cynyddol yn cydberthyn â chanlyniadau arennol. Mae fy grŵp wedi nodi targedau newydd sy'n gysylltiedig â Hyaluronan a'i broteinau rhwymol a all atal a gwrthdroi ffibrosis mewn systemau celloedd vitro. Mae'r ymchwil gyfredol bellach yn canolbwyntio ar ddatblygu agweddau trosiadol ar yr ymchwil hon ac yn dangos perthnasedd a chymhwysedd y targedau cellog hyn i bennu eu defnydd fel biofarcwyr wrth ragfynegi dilyniant clefyd arennol, yn ogystal ag ymchwilio i'w potensial fel therapïau gwrth-fibrotig newydd.
Meysydd ymchwil cysylltiedig
Mae gen i ddiddordeb gweithredol hefyd mewn deall y mecansims sy'n gyrru patholegau cardiofasgwlaidd mewn cleifion â chlefyd cronig yr arennau (CKD). Mae CKD bellach yn ail yn nifer yr achosion o glefyd y galon yn y byd datblygedig. Mae gan gleifion sydd â CKD cyfnod terfynol sydd ar ddialysis ganlyniadau tebyg (os nad gwaeth) i lawer o ganserau, ond nid yw hyn yn cael ei gydnabod yn dda. Diasitis cardiofasgwlaidd yw'r prif achos o afiachusrwydd a marwolaeth yn y grŵp hwn o gleifion. Yn anffodus, nid ydynt yn ymateb yn dda i therapïau cardiofasgwlaidd traddodiadol fel therapi gwrth-blatennau, therapi gostwng lipidau neu angioplasti percutaneous. Nod fy grŵp yw nodi'r mecanweithiau sy'n gyrru patholeg cardiofasgwlaidd mewn cleifion â chlefyd arennol ac ymchwilio i dargedau therapiwtig newydd. Mae meysydd ymchwil cysylltiedig eraill o fewn neffroleg yn cynnwys deall y mecanweithiau sy'n gyrru ffibrosis peritoneol ac sy'n arwain at fethiant dialysis peritoneol (PD) mewn cleifion â chlefyd arennol ac rwy'n un o'r Ymchwilwyr Prifathrawiaethol yn rhaglen ITN IMPROVE PD Marie Curie a ariennir gan Horizon 2020.
Ymchwil COVID19: Rwy'n cydweithio â grŵp o fewn y Gyfarwyddiaeth Neffroleg a Thrawsblaniadau clinigol yn ogystal â grwpiau ymchwil Imiwnoleg a Virolgy ym Mhrifysgol Caerdydd i ymchwilio i ymatebion brechlyn COVID19 mewn cleifion ar haemodialysis, gydag astudiaethau tebyg yn cael eu harwain mewn cleifion tranplanhigyn arennau sy'n cael eu rhedeg gan yr un grŵp.
Addysgu
Fi yw'r Arweinydd Arbenigedd ar gyfer addysg feddygol israddedig mewn Meddygaeth Arennol yn y Gyfarwyddiaeth Neffroleg a Thrawsblannu ac rwy'n Gadeirydd pwyllgor Llywodraethu Addysg yr adran, sy'n goruchwylio gwelliant mewn addysg a hyfforddiant arennol israddedig ac ôl-raddedig. Rwy'n eistedd ar bwyllgor Arennol STC yng Nghymru ac rwy'n Oruchwyliwr Addysgol a Chlinigol i nifer o hyfforddeion arbenigol a hyfforddeion y Rhaglen Sylfaen.
Rwy'n goruchwylio prosiectau ymchwil ar gyfer myfyrwyr PhD ac yn croesawu ymholiadau i oruchwylio myfyrwyr newydd, gan gynnwys myfyrwyr Meistr, myfyrwyr meddygol Intercalated a myfyrwyr israddedig PTY.
Yn ddiweddar, dyfarnwyd Medal Medawar i'm myfyriwr PhD diweddar Dr Charlotte Brown yng nghyfarfod Cymdeithas Trawsblannu Prydain ym mis Chwefror 2021 am ymchwil a wnaed yn fy Labordy.
Gweler gwefan Clwb Aren Cymru am fwy o wybodaeth am weithgareddau addysgu ac addysg yn ein hadran.
Bywgraffiad
Gweler dolen i'm bywgraffiad a gyhoeddwyd gan Kidney Research UK
Dolen i Adroddiad Bywyd Med Sci
Addysg a chymwysterau
- 2020: Ardystiad GCP (Arfer Clinigol Da mewn Ymchwil) (Ymchwil Iechyd a Gofal Cymru)
- 2020: FRCP, Coleg Brenhinol y Meddygon, y DU.
- 2012: Tystysgrif Cwblhau mewn Hyfforddiant (CCT) mewn Meddygaeth Arennol, Cyngor Meddygol Cyffredinol
- 2012: MRCP (DU, Meddygaeth Arennol), Coleg Brenhinol y Meddygon, y DU.
- 2008: PhD, Ysgol Meddygaeth, Prifysgol Caerdydd.
- 2004: MRCP (DU), Coleg Brenhinol y Meddygon, y DU.
- 1993 - MB ChB, Ysgol Feddygol Prifysgol Glasgow.
Trosolwg gyrfa
- 2016-presennol: Uwch Ddarlithydd Clinigol mewn Niwroleg, Ysgol Meddygaeth Prifysgol Caerdydd.
- 2016-presennol: Neffrolegydd Ymgynghorol Anrhydeddus yn BIP Caerdydd a'r Fro a Bwrdd Iechyd Prifysgol Aneurin Bevan.
- 2013-2019: Cymrodoriaeth Gwyddonydd Clinigwyr MRC, Ysgol Meddygaeth Prifysgol Caerdydd.
- 2007-2013: Cofrestrydd Arbenigol Academaidd mewn Neffroleg a Darlithydd Clinigol Walport, Deoniaeth Cymru.
- 2004-2007: Cymrawd Ymchwil Clinigol mewn Meddygaeth Arennol, Sefydliad Neffroleg, Ysgol Meddygaeth Prifysgol Caerdydd.
- 2001-2004: Uwch Swyddog Tŷ, cylchdroadau SHO Meddygol De Cymru.
- 2001-2001: Swyddog Tŷ mewn Llawfeddygaeth, Ysbyty Victoria, Glasgow.
- 2000-2001: Swyddog Tai mewn Meddygaeth, Ysbyty Brenhinol Glasgow.
- 1995-2000: Israddedigion Meddygol Prifysgol Glasgow.
Anrhydeddau a dyfarniadau
- 2013-2019: Cymrodoriaeth Gwyddonydd Clinigwyr MRC
- 2007: Gwobr Ymchwilydd Ifanc, Cymdeithas Atgyweirio Meinwe Ewropeaidd
- 2021: Medal Medawar Cymdeithas Trawsblannu Prydain yn cael ei dyfarnu i'r myfyriwr PhD Dr Charlotte Brown.
- 2018: Wythnos Aren y DU, y Cyflwyniad Llafar Haniaethol Gorau a ddyfarnwyd i'r myfyriwr PhD Dr Aled Williams.
- 2017: Cynhadledd Ryngwladol Soceity Gwyddorau Hyaluronan, Cleveland, Gwobr Ymchwil Mark Lauer i Dr Adam Midgley, ymchwilydd ôl-ddoethurol yn fy ngrŵp.
- 2016: Wythnos Aren y DU, Ymchwilydd Gyrfa Gynnar a ddyfarnwyd i Dr Adam Midgley, ymchwilydd ôl-ddoethurol yn fy ngrŵp.
Aelodaethau proffesiynol
- Aelod o Fwrdd Cymdeithas Ryngwladol Gwyddorau Hyaluronan.
- Cymrawd Coleg Brenhinol y Meddygon, y Deyrnas Unedig.
- Cymdeithas Neffroleg America, Aelod.
- Cymdeithas Arennol y Deyrnas Unedig, Aelod.
- Ymgeisydd SUSTAIN Academi Gwyddoniaeth Feddygol 2015-2016
Safleoedd academaidd blaenorol
- 2012-presennol: Uwch Ddarlithydd Clinigol yn Nephrolgy, Ysgol Meddygaeth, Prifysgol Caerdydd.
- 2012-2019: Cymrawd Gwyddonydd Clinigwr MRC, Ysgol Meddygaeth, Prifysgol Caerdydd.
- 2007-2012: Darlithydd Clinigol Walport, Ysgol Meddygaeth, Prifysgol Caerdydd.
- 2004-2007: myfyriwr PhD, Ysgol Meddygaeth, Prifysgol Caerdydd.
Meysydd goruchwyliaeth
Ardaloedd dan oruchwyliaeth
- Meddygaeth Arennol
- Anaf Acíwt i'r Arennau
- Clefyd cronig yr arennau
- Peritoneal Dialysis
- Hyaluronan a Matrix Bioleg
- Fibrosis Bioleg
- patholeg cardiofasgwlaidd mewn clefyd arennol
