Yr Athro Valerie O'Donnell
PhD FMedSci MAE FLSW
Athro biocemeg lipid, Is-adran Haint ac Imiwnedd
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Overview
Our research uses mass spectrometry to discover and characterise new lipids (fats) made by circulating vascular cells that regulate immune defence and blood clotting.
Recently we showed that human blood platelets generate a large number of oxidized phospholipids several of which help clotting factors in plasma work more effectively. We also uncovered a new role for phospholipases in providing energy to the cell and how lipids in different people respond individually to aspirin (http://www.cardiff.ac.uk/news/view/264589-understanding-the-bodys-response-to-aspirin)
In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).
Our current research is focused on understanding the role of new lipids in vascular inflammation including cardiovascular disease, dementia and wound healing. Some lipids we discovered are being developed as the basis of new treatments for bleeding excess.
Research in our group is funded by grants from the European Research Council, Wellcome Trust, British Heart Foundation and Medical Research Council.
Cyhoeddiad
2025
- Ghorasaini, M., Costa, D., Tyrrell, V. J., Protty, M., Giera, M. and O'Donnell, V. B. 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology., Vol. 2855. New York, NY, USA: Springer, pp. 155-169., (10.1007/978-1-0716-4116-3_10)
2024
- Protty, M. B. et al. 2024. Thrombin generation is associated with extracellular vesicle and leukocyte lipid membranes in atherosclerotic cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 44(9), pp. 2038-2052. (10.1161/ATVBAHA.124.320902)
- Kopczynski, D. et al. 2024. The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data. Journal of Lipid Research 65(9), article number: 100621. (10.1016/j.jlr.2024.100621)
- Parchem, K. et al. 2024. Oxylipin profiling for clinical research: Current status and future perspectives. Progress in Lipid Research 95, article number: 101276. (10.1016/j.plipres.2024.101276)
- Burton, R. J. et al. 2024. Conventional and unconventional T cell responses contribute to the prediction of clinical outcome and causative bacterial pathogen in sepsis patients. Clinical & Experimental Immunology 216(3), pp. 293-306. (10.1093/cei/uxae019)
- Hajeyah, A. A. et al. 2024. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease.. Journal of Lipid Research 65(1), article number: 100484. (10.1016/j.jlr.2023.100484)
- Allen, N. et al. 2024. Prospective study design and data analysis in UK Biobank. Science Translational Medicine 16(729), article number: eadf4428. (10.1126/scitranslmed.adf4428)
- Witting, M. et al. 2024. Challenges and perspectives for naming lipids in the context of lipidomics. Metabolomics 20(1), article number: 15. (10.1007/s11306-023-02075-x)
2023
- O’Donnell, V. B. et al. 2023. Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples. Nature Communications 14(1), article number: 7172. (10.1038/s41467-023-41766-w)
- Conroy, M. J. et al. 2023. LIPID MAPS: Update to databases and tools for the lipidomics community. Nucleic Acids Research, article number: gkad896. (10.1093/nar/gkad896)
- Schönichen, C. et al. 2023. Antagonistic roles of human platelet integrin αIIbβ3 and chemokines in regulating neutrophil activation and fate on arterial thrombi under flow. Arteriosclerosis, Thrombosis, and Vascular Biology 43, pp. 1700-1712. (10.1161/ATVBAHA.122.318767)
- Czyzowska, A. et al. 2023. Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. Redox Biology 64, article number: 102761. (10.1016/j.redox.2023.102761)
- Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
- Oruganti, S. et al. 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13, article number: e067002. (10.1136/bmjopen-2022-067002)
- Sarmad, S. et al. 2023. A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP/UK). Nature Protocols (10.1038/s41596-022-00801-8)
- O'Donnell, V. B. 2023. Lipidomics moves to center stage of biomedicine. Function 4(1), article number: zqac071. (10.1093/function/zqac071)
2022
- Ni, Z. et al. 2022. Guiding the choice of informatics software and tools for lipidomics research applications. Nature Methods 20(2), pp. 193-204. (10.1038/s41592-022-01710-0)
- Brown, J. L. et al. 2022. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. Redox Biology 57, article number: 102518. (10.1016/j.redox.2022.102518)
- McDonald, J. G. et al. 2022. Introducing the lipidomics minimal reporting checklist. Nature Metabolism 4(9), pp. 1086–1088. (10.1038/s42255-022-00628-3)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Schebb, N. H. et al. 2022. Formation, signaling and occurrence of specialized pro-resolving lipid mediators - What is the evidence so far?. Frontiers in Pharmacology 13, article number: 838782. (10.3389/fphar.2022.838782)
- O'Donnell, V. B. 2022. New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease. Biochemical Society Transactions 50(1), pp. 1-11. (10.1042/BST20210579)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
2021
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Diskin, C., Zotta, A., Corcoran, S. E., Tyrrell, V. J., Zaslona, Z., O'Donnell, V. B. and O'Neill, L. A. J. 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207(10), pp. 2561-2569. (10.4049/jimmunol.2100488)
- Diskin, C. et al. 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207(10), pp. 2551-2560. (10.4049/jimmunol.2100402)
- Köfeler, H. C. et al. 2021. Quality control requirements for the correct annotation of lipidomics data. Nature Communications 12(1), article number: 4771. (10.1038/s41467-021-24984-y)
- Chan, M. V. et al. 2021. Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. Haematologica 106(5), pp. 1423-1432. (10.3324/haematol.2019.235895)
- Alvarez-Jarreta, J. et al. 2021. LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications. Bioinformatics 37(10), pp. 1478-1479. (10.1093/bioinformatics/btaa856)
- Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
- Gaud, C. et al. 2021. BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. F1000Research 10(4) (10.12688/f1000research.28022.1)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)
2020
- Liebisch, G. et al. 2020. Update on LIPID MAPS classification, nomenclature and shorthand notation for MS-derived lipid structures. Journal of Lipid Research 61, pp. 1539-1555. (10.1194/jlr.S120001025)
- Hajeyah, A. A., Griffiths, W. J., Wang, Y., Finch, A. J. and O'Donnell, V. B. 2020. The biosynthesis of enzymatically oxidized lipids. Frontiers in Endocrinology 11, article number: 591819. (10.3389/fendo.2020.591819)
- O'Donnell, V. B. et al. 2020. Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications. Circulation: Genomic and Precision Medicine 13(6), article number: e003019. (10.1161/CIRCGEN.120.003019)
- Rosas, M. et al. 2020. The procoagulant activity of tissue factor expressed on fibroblasts is increased by tissue factor-negative extracellular vesicles. PLoS ONE 15(10), article number: e0240189. (10.1371/journal.pone.0240189)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)
2019
- Doll, S. et al. 2019. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, pp. 693-698. (10.1038/s41586-019-1707-0)
- Gallagher, H. et al. 2019. Dihimo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis. BBA - Molecular Basis of Disease 1865(9), pp. 2538-2550. (10.1016/j.bbadis.2019.06.011)
- Hinz, C. et al. 2019. A comprehensive UHPLC ion mobility QTOF method for profiling and quantification of eicosanoids, other oxylipins and fatty acids. Analytical Chemistry 91(13), pp. 8025-8035. (10.1021/acs.analchem.8b04615)
- Kornilov, A. et al. 2019. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13- hydroxy-eicosadienoic acid. Journal of Biological Chemistry 294, pp. 9225-9238. (10.1074/jbc.RA119.008915)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Evans, R. J. et al. 2019. 15-keto-prostaglandin E₂ activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathogens 15(3), article number: e1007597. (10.1371/journal.ppat.1007597)
- O'Donnell, V., Aldrovandi, M., Murphy, R. C. and Kronke, G. 2019. Enzymatically-oxidized phospholipids assume center-stage as essential regulators of innate immunity and cell death. Science Signaling 12(574), article number: eaau2293. (10.1126/scisignal.aau2293)
- Fahy, E. et al. 2019. LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics. Bioinformatics 35(4), pp. 685-687. (10.1093/bioinformatics/bty679)
- O'Donnell, V., Dennis, E. A., Wakelam, M. J. O. and Subramaniam, S. 2019. LIPID MAP: Serving the next generation of lipid researchers with tools, resources, data and training. Science Signaling 12(563), article number: eaaw2964. (10.1126/scisignal.aaw2964)
2018
- Vliet, A. v. d. et al. 2018. Rust never sleeps: the continuing story of the Iron Bolt. Free Radical Biology and Medicine 124, pp. 353-357. (10.1016/j.freeradbiomed.2018.06.017)
- O'Donnell, V., Rossjohn, J. and Wakelam, M. J. O. 2018. Phospholipid signaling in innate immune cells. The Journal of Clinical Investigation 128(7), pp. 2670-2679. (10.1172/JCI97944)
- Freeman, B. A., O'Donnell, V. B. and Schopfer, F. J. 2018. The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling. Nitric Oxide: Biology and Chemistry 77, pp. 106-111. (10.1016/j.niox.2018.05.002)
- Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3(6), article number: e98459. (10.1172/jci.insight.98459)
- Walker, J. et al. 2018. Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin. ecancermedicalscience 12, article number: 813. (10.3332/ecancer.2018.813)
- Aldrovandi, M., Banthiya, S., Meckelmann, S., Zhou, Y., Heydeck, D., O'Donnell, V. B. and Kuhn, H. 2018. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(2), pp. 152-164. (10.1016/j.bbalip.2017.11.005)
- O'Donnell, V. B. 2018. Gus Born: scientific reflections of later years, inspiring the next generation of blood researchers. Platelets 29(8), pp. 763-765. (10.1080/09537104.2018.1534948)
2017
- Zhao, J. et al. 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57(6) (10.1165/rcmb.2017-0031OC)
- Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10(507), article number: eaan2787. (10.1126/scisignal.aan2787)
- Lue, H. et al. 2017. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes and Development 31, pp. 2067-2084. (10.1101/gad.305292.117)
- Uderhardt, S. et al. 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214(7), pp. 2121-2138. (10.1084/jem.20161070)
- O'Donnell, V. B. and Murphy, R. C. 2017. Directing eicosanoid esterification into phospholipids. Journal of Lipid Research 58(5), pp. 837-839. (10.1194/jlr.C075986)
- O'Connor, A., Brasher, C., Slatter, D., Meckelmann, S., Hawksworth, J., Allen, S. and O'Donnell, V. 2017. LipidFinder: a computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets. JCI Insight 2(7), pp. e91634. (10.1172/jci.insight.91634)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)
2016
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Heurich-Sevcenco, M., Preston, R., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017)
- Stokes, C. A. et al. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9(5), pp. 1303-1316. (10.1038/mi.2015.137)
- Chiba, T., Thomas, C. P., Calcutt, M. W., Boeglin, W. E., O'Donnell, V. B. and Brash, A. R. 2016. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate. Journal of Biological Chemistry 291(28), pp. 14540-14544. (10.1074/jbc.M115.711267)
- Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
- Hinz, C. et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291(26), pp. 13448-13464. (10.1074/jbc.M115.700609)
- Slatter, D. A. et al. 2016. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation. Cell Metabolism 23(5), pp. 930-944. (10.1016/j.cmet.2016.04.001)
- Jones, V. et al. 2016. Role of Ep2 and Ep4 receptors in airway microvascular leak induced by prostaglandin E2. British Journal of Pharmacology 173(6), pp. 992-1004. (10.1111/bph.13400)
2015
- Freeman, P., Moschonas, K., Hinz, C., O'Donnell, V. B., Kinnaird, T. D., James, P. E. and Anderson, R. A. 2015. Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients. Atherosclerosis 243(1), pp. 320-327. (10.1016/j.atherosclerosis.2015.09.024)
- McCully, M. L., Collins, P. J., Hughes, T. R., Thomas, C. P., Billen, J., O'Donnell, V. B. and Moser, B. 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. Journal of Immunology 195(1), pp. 96-104. (10.4049/jimmunol.1402961)
- Percy, C. L. et al. 2015. Correcting thrombin generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass. Blood Coagulation and Fibrinolysis 26(4), pp. 357-367. (10.1097/MBC.0000000000000243)
- Ravi, S. et al. 2015. Metabolic plasticity in resting and thrombin activated platelets. PLoS ONE 10(4), article number: e0123597. (10.1371/journal.pone.0123597)
- Morgan, A. H. et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005)
2014
- Friedmann Angeli, J. P. et al. 2014. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nature Cell Biology 16, pp. 1180-1191. (10.1038/ncb3064)
- Mathie, S. A. et al. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70(1), pp. 80-89. (10.1111/all.12536)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40(1), pp. 40-50. (10.1016/j.immuni.2013.10.022)
- Thomas, C. P., Clark, S. R., Hammond, V. J., Aldrovandi, M., Collins, P. W. and O'Donnell, V. B. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63. (10.1038/nprot.2013.163)
- O'Donnell, V., Murphy, R. C. and Watson, S. P. 2014. Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circulation Research 114(7), pp. 1185-1203. (10.1161/CIRCRESAHA.114.301597)
2013
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54(11), pp. 3085-3097. (10.1194/jlr.M041533)
- Pauling, J. D., O'Donnell, V. B. and Mchugh, N. J. 2013. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets 24(7), pp. 503-515. (10.3109/09537104.2012.719090)
- Bonilla, L., O'Donnell, V. B., Clark, S. R., Rubbo, H. and Trostchansky, A. 2013. Regulation of protein kinase C by nitroarachidonic acid: impact on human platelet activation. Archives of Biochemistry and Biophysics 533(1-2), pp. 55-61. (10.1016/j.abb.2013.03.001)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110)
- Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52(s1), pp. 138-139.
- Aldrovandi, M. and O'Donnell, V. B. 2013. Oxidized PLs and vascular inflammation. Current Atherosclerosis Reports 15(5), pp. 1989-1996., article number: 323. (10.1007/s11883-013-0323-y)
2012
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818(10), pp. 2403-2412. (10.1016/j.bbamem.2011.12.013)
- Reynolds, S. L. et al. 2012. Contractile, but not endothelial, dysfunction in early inflammatory arthritis: a possible role for matrix metalloproteinase-9. British Journal of Pharmacology 167(3), pp. 505-514. (10.1111/j.1476-5381.2012.01988.x)
- O'Donnell, V. B. and Murphy, R. C. 2012. New families of bioactive oxidized phospholipids generated by immune cells: Identification and signaling actions. Blood 120(10), pp. 1985-1992. (10.1182/blood-2012-04-402826)
- Thomas, C. P. and O'Donnell, V. B. 2012. Oxidized phospholipid signaling in immune cells. Current Opinion in Pharmacology 12(4), pp. 471-477. (10.1016/j.coph.2012.02.013)
- Taylor, P. R. et al. 2012. Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter]. Blood 119(25), pp. 6173-6174. (10.1182/blood-2012-02-410928)
2011
- O'Donnell, V. B. 2011. Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1811(11), pp. 818-826. (10.1016/j.bbalip.2011.07.018)
- Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
- Guschina, I., Millership, S., O'Donnell, V. B., Ninkina, N., Harwood, J. and Buchman, V. L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46(2), pp. 121-130. (10.1007/s11745-010-3486-0)
- Ruge, F. et al. 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131(3), pp. 572-579. (10.1038/jid.2010.379)
- Zhao, J., O'Donnell, V. B., Balzar, S., St. Croix, C. M., Trudeau, J. B. and Wenzel, S. E. 2011. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 108(34), pp. 14246-14251. (10.1073/pnas.1018075108)
- Trostchansky, A., Bonilla, L., Thomas, C. P., O'Donnell, V. B., Marnett, L. J., Radi, R. and Rubbo, H. 2011. Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2. Journal of Biological Chemistry 286(15), pp. 12891-12900. (10.1074/jbc.M110.154518)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
2010
- Thomas, C. P. et al. 2010. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. Journal of Biological Chemistry 285(10), pp. 6891-6903. (10.1074/jbc.M109.078428)
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5(12), pp. 1919-1931. (10.1038/nprot.2010.162)
- Ivanov, I., Heydeck, D., Hofheinz, K., Roffeis, J., O'Donnell, V. B., Kuhn, H. and Walther, M. 2010. Molecular enzymology of lipoxygenases. Archives of biochemistry and biophysics 503(2), pp. 161-174. (10.1016/j.abb.2010.08.016)
- Morgan, L. T., Thomas, C. P., Kühn, H. and O'Donnell, V. B. 2010. Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase. Biochemical Journal 431(1), pp. 141-148. (10.1042/BJ20100415)
2009
- Tull, S. P. et al. 2009. Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biology 7(8), article number: e1000177. (10.1371/journal.pbio.1000177)
- Rubbo, H., Trostchansky, A. and O'Donnell, V. B. 2009. Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences. Archives of Biochemistry and Biophysics 484(2), pp. 167-172. (10.1016/j.abb.2008.11.007)
- Ferreira, A. et al. 2009. Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate. Biochemical Journal 417(1), pp. 223-234. (10.1042/BJ20080701)
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- Baker, P. R. S., Schopfer, F. J., O'Donnell, V. B. and Freeman, B. A. 2009. Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids. Free Radical Biology & Medicine 46(8), pp. 989-1003. (10.1016/j.freeradbiomed.2008.11.021)
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2008
- Morton, J. et al. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111(10), pp. 5187-5194. (10.1182/blood-2007-10-117283)
- Dioszeghy, V. et al. 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181(9), pp. 6514-6524.
2007
- Coles, B., Fielding, C. A., Rose-John, S., Scheller, J., Jones, S. A. and O'Donnell, V. B. 2007. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. American Journal of Pathology 171(1), pp. 315-325. (10.2353/ajpath.2007.061078)
2006
- Anning, P. B. et al. 2006. Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. Blood 108(13), pp. 4059-4062. (10.1182/blood-2006-02-005330)
2005
- Williams, P. C. et al. 2005. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Blood 106(8), pp. 2737-2743. (10.1182/blood-2005-02-0664)
- Clark, S. R., Anning, P. B., Coffey, M. J., Roberts, A. G., Marnett, L. J. and O'Donnell, V. B. 2005. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. Biochemical Journal 385(3), pp. 815-821. (10.1042/BJ20041353)
2004
- Coffey, M. J., Coles, B., Locke, M., Bermudez-Fajardo, A., Williams, P. C., Jarvis, G. E. and O'Donnell, V. B. 2004. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. FEBS Letters 576(1-2), pp. 165-168. (10.1016/j.febslet.2004.09.007)
- Coffey, M. J., Jarvis, G. E., Gibbins, J. M., Coles, B., Barrett, N. E., Wylie, O. R. and O'Donnell, V. B. 2004. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circulation Research 94(12), pp. 1598-1605. (10.1161/01.RES.0000132281.78948.65)
2002
- Clark, S. R., Coffey, M. J., McLean, R. M., Collins, P. W., Lewis, M. J., Cross, A. R. and O'Donnell, V. B. 2002. Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. The Journal of Immunology 169(10), pp. 5889-5896.
- Coles, B., Bloodsworth, A., Clark, S. R., Lewis, M. J., Cross, A. R., Freeman, B. A. and O'Donnell, V. B. 2002. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. Circulation Research 91(5), pp. 375-381. (10.1161/01.RES.0000032114.68919.EF)
2001
- Coffey, M. J. et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98(14), pp. 8006-8011. (10.1073/pnas.141136098)
Articles
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- Witting, M. et al. 2024. Challenges and perspectives for naming lipids in the context of lipidomics. Metabolomics 20(1), article number: 15. (10.1007/s11306-023-02075-x)
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- O'Donnell, V. B. 2023. Lipidomics moves to center stage of biomedicine. Function 4(1), article number: zqac071. (10.1093/function/zqac071)
- Ni, Z. et al. 2022. Guiding the choice of informatics software and tools for lipidomics research applications. Nature Methods 20(2), pp. 193-204. (10.1038/s41592-022-01710-0)
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- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Protty, M. B., Jenkins, P. V., Collins, P. W. and O'Donnell, V. B. 2022. The role of procoagulant phospholipids on the surface of circulating blood cells in thrombosis and haemostasis. Open Biology 12(4), article number: 210318. (10.1098/rsob.210318)
- Schebb, N. H. et al. 2022. Formation, signaling and occurrence of specialized pro-resolving lipid mediators - What is the evidence so far?. Frontiers in Pharmacology 13, article number: 838782. (10.3389/fphar.2022.838782)
- O'Donnell, V. B. 2022. New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease. Biochemical Society Transactions 50(1), pp. 1-11. (10.1042/BST20210579)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Diskin, C., Zotta, A., Corcoran, S. E., Tyrrell, V. J., Zaslona, Z., O'Donnell, V. B. and O'Neill, L. A. J. 2021. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. Journal of Immunology 207(10), pp. 2561-2569. (10.4049/jimmunol.2100488)
- Diskin, C. et al. 2021. The Trypanosome-derived metabolite indole-3-pyruvate inhibits prostaglandin production in macrophages by targeting COX2. Journal of Immunology 207(10), pp. 2551-2560. (10.4049/jimmunol.2100402)
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- Gaud, C. et al. 2021. BioPAN: a web-based tool to explore mammalian lipidome metabolic pathways on LIPID MAPS. F1000Research 10(4) (10.12688/f1000research.28022.1)
- Tyrrell, V. J. et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)
- Liebisch, G. et al. 2020. Update on LIPID MAPS classification, nomenclature and shorthand notation for MS-derived lipid structures. Journal of Lipid Research 61, pp. 1539-1555. (10.1194/jlr.S120001025)
- Hajeyah, A. A., Griffiths, W. J., Wang, Y., Finch, A. J. and O'Donnell, V. B. 2020. The biosynthesis of enzymatically oxidized lipids. Frontiers in Endocrinology 11, article number: 591819. (10.3389/fendo.2020.591819)
- O'Donnell, V. B. et al. 2020. Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications. Circulation: Genomic and Precision Medicine 13(6), article number: e003019. (10.1161/CIRCGEN.120.003019)
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- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)
- Doll, S. et al. 2019. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, pp. 693-698. (10.1038/s41586-019-1707-0)
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- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
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- O'Donnell, V., Aldrovandi, M., Murphy, R. C. and Kronke, G. 2019. Enzymatically-oxidized phospholipids assume center-stage as essential regulators of innate immunity and cell death. Science Signaling 12(574), article number: eaau2293. (10.1126/scisignal.aau2293)
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- O'Donnell, V., Dennis, E. A., Wakelam, M. J. O. and Subramaniam, S. 2019. LIPID MAP: Serving the next generation of lipid researchers with tools, resources, data and training. Science Signaling 12(563), article number: eaaw2964. (10.1126/scisignal.aaw2964)
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- O'Donnell, V., Rossjohn, J. and Wakelam, M. J. O. 2018. Phospholipid signaling in innate immune cells. The Journal of Clinical Investigation 128(7), pp. 2670-2679. (10.1172/JCI97944)
- Freeman, B. A., O'Donnell, V. B. and Schopfer, F. J. 2018. The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling. Nitric Oxide: Biology and Chemistry 77, pp. 106-111. (10.1016/j.niox.2018.05.002)
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- Walker, J. et al. 2018. Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin. ecancermedicalscience 12, article number: 813. (10.3332/ecancer.2018.813)
- Aldrovandi, M., Banthiya, S., Meckelmann, S., Zhou, Y., Heydeck, D., O'Donnell, V. B. and Kuhn, H. 2018. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(2), pp. 152-164. (10.1016/j.bbalip.2017.11.005)
- O'Donnell, V. B. 2018. Gus Born: scientific reflections of later years, inspiring the next generation of blood researchers. Platelets 29(8), pp. 763-765. (10.1080/09537104.2018.1534948)
- Zhao, J. et al. 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57(6) (10.1165/rcmb.2017-0031OC)
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- Lue, H. et al. 2017. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes and Development 31, pp. 2067-2084. (10.1101/gad.305292.117)
- Uderhardt, S. et al. 2017. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis and thrombotic disease. Journal of Experimental Medicine 214(7), pp. 2121-2138. (10.1084/jem.20161070)
- O'Donnell, V. B. and Murphy, R. C. 2017. Directing eicosanoid esterification into phospholipids. Journal of Lipid Research 58(5), pp. 837-839. (10.1194/jlr.C075986)
- O'Connor, A., Brasher, C., Slatter, D., Meckelmann, S., Hawksworth, J., Allen, S. and O'Donnell, V. 2017. LipidFinder: a computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets. JCI Insight 2(7), pp. e91634. (10.1172/jci.insight.91634)
- Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11, pp. 663-672. (10.1016/j.redox.2017.01.001)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Heurich-Sevcenco, M., Preston, R., O'Donnell, V. B., Morgan, B. P. and Collins, P. W. 2016. Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex. Thrombosis Research 145, pp. 84-92. (10.1016/j.thromres.2016.07.017)
- Stokes, C. A. et al. 2016. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunology 9(5), pp. 1303-1316. (10.1038/mi.2015.137)
- Chiba, T., Thomas, C. P., Calcutt, M. W., Boeglin, W. E., O'Donnell, V. B. and Brash, A. R. 2016. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate. Journal of Biological Chemistry 291(28), pp. 14540-14544. (10.1074/jbc.M115.711267)
- Bascoul-Colombo, C., Guschina, I. A., Maskrey, B. H., Good, M., O'Donnell, V. B. and Harwood, J. L. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1861(6), pp. 524-537. (10.1016/j.bbalip.2016.03.005)
- Hinz, C. et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291(26), pp. 13448-13464. (10.1074/jbc.M115.700609)
- Slatter, D. A. et al. 2016. Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation. Cell Metabolism 23(5), pp. 930-944. (10.1016/j.cmet.2016.04.001)
- Jones, V. et al. 2016. Role of Ep2 and Ep4 receptors in airway microvascular leak induced by prostaglandin E2. British Journal of Pharmacology 173(6), pp. 992-1004. (10.1111/bph.13400)
- Freeman, P., Moschonas, K., Hinz, C., O'Donnell, V. B., Kinnaird, T. D., James, P. E. and Anderson, R. A. 2015. Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients. Atherosclerosis 243(1), pp. 320-327. (10.1016/j.atherosclerosis.2015.09.024)
- McCully, M. L., Collins, P. J., Hughes, T. R., Thomas, C. P., Billen, J., O'Donnell, V. B. and Moser, B. 2015. Skin metabolites define a new paradigm in the localization of skin tropic memory T cells. Journal of Immunology 195(1), pp. 96-104. (10.4049/jimmunol.1402961)
- Percy, C. L. et al. 2015. Correcting thrombin generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass. Blood Coagulation and Fibrinolysis 26(4), pp. 357-367. (10.1097/MBC.0000000000000243)
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- Morgan, A. H. et al. 2015. A novel role for 12/15-lipoxygenase in regulating autophagy. Redox Biology 4, pp. 40-47. (10.1016/j.redox.2014.11.005)
- Friedmann Angeli, J. P. et al. 2014. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nature Cell Biology 16, pp. 1180-1191. (10.1038/ncb3064)
- Mathie, S. A. et al. 2014. Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge. Allergy 70(1), pp. 80-89. (10.1111/all.12536)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40(1), pp. 40-50. (10.1016/j.immuni.2013.10.022)
- Thomas, C. P., Clark, S. R., Hammond, V. J., Aldrovandi, M., Collins, P. W. and O'Donnell, V. B. 2014. Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. Nature Protocols 9(1), pp. 51-63. (10.1038/nprot.2013.163)
- O'Donnell, V., Murphy, R. C. and Watson, S. P. 2014. Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circulation Research 114(7), pp. 1185-1203. (10.1161/CIRCRESAHA.114.301597)
- Aldrovandi, M. et al. 2013. Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. Journal of Lipid Research 54(11), pp. 3085-3097. (10.1194/jlr.M041533)
- Pauling, J. D., O'Donnell, V. B. and Mchugh, N. J. 2013. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets 24(7), pp. 503-515. (10.3109/09537104.2012.719090)
- Bonilla, L., O'Donnell, V. B., Clark, S. R., Rubbo, H. and Trostchansky, A. 2013. Regulation of protein kinase C by nitroarachidonic acid: impact on human platelet activation. Archives of Biochemistry and Biophysics 533(1-2), pp. 55-61. (10.1016/j.abb.2013.03.001)
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- Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52(s1), pp. 138-139.
- Aldrovandi, M. and O'Donnell, V. B. 2013. Oxidized PLs and vascular inflammation. Current Atherosclerosis Reports 15(5), pp. 1989-1996., article number: 323. (10.1007/s11883-013-0323-y)
- Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287(50), pp. 41651-41666. (10.1074/jbc.M112.405407)
- Hammond, V. J. and O'Donnell, V. B. 2012. Esterified eicosanoids: generation, characterization and function. Biochimica et Biophysica Acta - Biomembranes 1818(10), pp. 2403-2412. (10.1016/j.bbamem.2011.12.013)
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- O'Donnell, V. B. and Murphy, R. C. 2012. New families of bioactive oxidized phospholipids generated by immune cells: Identification and signaling actions. Blood 120(10), pp. 1985-1992. (10.1182/blood-2012-04-402826)
- Thomas, C. P. and O'Donnell, V. B. 2012. Oxidized phospholipid signaling in immune cells. Current Opinion in Pharmacology 12(4), pp. 471-477. (10.1016/j.coph.2012.02.013)
- Taylor, P. R. et al. 2012. Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter]. Blood 119(25), pp. 6173-6174. (10.1182/blood-2012-02-410928)
- O'Donnell, V. B. 2011. Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1811(11), pp. 818-826. (10.1016/j.bbalip.2011.07.018)
- Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
- Guschina, I., Millership, S., O'Donnell, V. B., Ninkina, N., Harwood, J. and Buchman, V. L. 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46(2), pp. 121-130. (10.1007/s11745-010-3486-0)
- Ruge, F. et al. 2011. Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated. Journal of Investigative Dermatology 131(3), pp. 572-579. (10.1038/jid.2010.379)
- Zhao, J., O'Donnell, V. B., Balzar, S., St. Croix, C. M., Trudeau, J. B. and Wenzel, S. E. 2011. 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 108(34), pp. 14246-14251. (10.1073/pnas.1018075108)
- Trostchansky, A., Bonilla, L., Thomas, C. P., O'Donnell, V. B., Marnett, L. J., Radi, R. and Rubbo, H. 2011. Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2. Journal of Biological Chemistry 286(15), pp. 12891-12900. (10.1074/jbc.M110.154518)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
- Thomas, C. P. et al. 2010. Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation. Journal of Biological Chemistry 285(10), pp. 6891-6903. (10.1074/jbc.M109.078428)
- Morgan, A. H. et al. 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5(12), pp. 1919-1931. (10.1038/nprot.2010.162)
- Ivanov, I., Heydeck, D., Hofheinz, K., Roffeis, J., O'Donnell, V. B., Kuhn, H. and Walther, M. 2010. Molecular enzymology of lipoxygenases. Archives of biochemistry and biophysics 503(2), pp. 161-174. (10.1016/j.abb.2010.08.016)
- Morgan, L. T., Thomas, C. P., Kühn, H. and O'Donnell, V. B. 2010. Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase. Biochemical Journal 431(1), pp. 141-148. (10.1042/BJ20100415)
- Tull, S. P. et al. 2009. Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biology 7(8), article number: e1000177. (10.1371/journal.pbio.1000177)
- Rubbo, H., Trostchansky, A. and O'Donnell, V. B. 2009. Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences. Archives of Biochemistry and Biophysics 484(2), pp. 167-172. (10.1016/j.abb.2008.11.007)
- Ferreira, A. et al. 2009. Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate. Biochemical Journal 417(1), pp. 223-234. (10.1042/BJ20080701)
- Maskrey, B. H. et al. 2009. Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase [Addition]. Journal of Biological Chemistry 284(37), pp. 25460. (10.1074/jbc.A611776200)
- Morgan, A. H. et al. 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284(32), pp. 21185-21191. (10.1074/jbc.M109.021634)
- Baker, P. R. S., Schopfer, F. J., O'Donnell, V. B. and Freeman, B. A. 2009. Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids. Free Radical Biology & Medicine 46(8), pp. 989-1003. (10.1016/j.freeradbiomed.2008.11.021)
- Gregory, L. G. et al. 2009. Inhaled house dust mite induces pulmonary T helper 2 cytokine production. Clinical and Experimental Allergy 39(10), pp. 1597-1610. (10.1111/j.1365-2222.2009.03302.x)
- Zhao, J. et al. 2009. Interleukin-13-induced MUC5AC is regulated by 15-Lipoxygenase 1 pathway in human bronchial epithelial cells. American Journal of Respiratory and Critical Care Medicine 179(9), pp. 782-790. (10.1164/rccm.200811-1744OC)
- Morton, J. et al. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111(10), pp. 5187-5194. (10.1182/blood-2007-10-117283)
- Dioszeghy, V. et al. 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181(9), pp. 6514-6524.
- Coles, B., Fielding, C. A., Rose-John, S., Scheller, J., Jones, S. A. and O'Donnell, V. B. 2007. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. American Journal of Pathology 171(1), pp. 315-325. (10.2353/ajpath.2007.061078)
- Anning, P. B. et al. 2006. Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. Blood 108(13), pp. 4059-4062. (10.1182/blood-2006-02-005330)
- Williams, P. C. et al. 2005. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Blood 106(8), pp. 2737-2743. (10.1182/blood-2005-02-0664)
- Clark, S. R., Anning, P. B., Coffey, M. J., Roberts, A. G., Marnett, L. J. and O'Donnell, V. B. 2005. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. Biochemical Journal 385(3), pp. 815-821. (10.1042/BJ20041353)
- Coffey, M. J., Coles, B., Locke, M., Bermudez-Fajardo, A., Williams, P. C., Jarvis, G. E. and O'Donnell, V. B. 2004. Interactions of 12-lipoxygenase with phospholipase A2 isoforms following platelet activation through the glycoprotein VI collagen receptor. FEBS Letters 576(1-2), pp. 165-168. (10.1016/j.febslet.2004.09.007)
- Coffey, M. J., Jarvis, G. E., Gibbins, J. M., Coles, B., Barrett, N. E., Wylie, O. R. and O'Donnell, V. B. 2004. Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circulation Research 94(12), pp. 1598-1605. (10.1161/01.RES.0000132281.78948.65)
- Clark, S. R., Coffey, M. J., McLean, R. M., Collins, P. W., Lewis, M. J., Cross, A. R. and O'Donnell, V. B. 2002. Characterization of nitric oxide consumption pathways by normal, chronic granulomatous disease and myeloperoxidase-deficient human neutrophils. The Journal of Immunology 169(10), pp. 5889-5896.
- Coles, B., Bloodsworth, A., Clark, S. R., Lewis, M. J., Cross, A. R., Freeman, B. A. and O'Donnell, V. B. 2002. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. Circulation Research 91(5), pp. 375-381. (10.1161/01.RES.0000032114.68919.EF)
- Coffey, M. J. et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98(14), pp. 8006-8011. (10.1073/pnas.141136098)
Book sections
- Ghorasaini, M., Costa, D., Tyrrell, V. J., Protty, M., Giera, M. and O'Donnell, V. B. 2025. A method for analysis of oxidized phospholipids from biological samples using mass spectrometry. In: Giera, M. and Sánchez-López, E. eds. Methods in Molecular Biology., Vol. 2855. New York, NY, USA: Springer, pp. 155-169., (10.1007/978-1-0716-4116-3_10)
Ymchwil
Metrigau
Google Scholar H-index 63. Dyfyniadau 3,273 yn 2022, cyfanswm dyfyniadau 25.5K
Dychwelodd cyhoeddiadau yn RAE2002, RAE2008 a REF2014 gyda 7 adolygiad allanol yn 3-4* yn REF2014, arweinydd neu gyd-awdur ar 9 cyhoeddiad a ddychwelwyd yn REF2021.
Ymchwil diweddar gan ein labordy
Mae astudiaethau diweddar wedi canolbwyntio ar ddeall sut mae dileu mitocondrial o oxylipins yn cael ei reoli yn ystod llid. Fe wnaethom nodi genynnau sy'n cael eu hisraddio i ddarparu metaboledd cynyddol trwy ocsidiad B yn dilyn ymsefydlu llid in vivo neu in vitro a datgelu rôl newydd ar gyfer yr ensym Carnitine palmitoyl transferase 1 (CPT1) yn y broses hon (Misheva et al). Ariannwyd gan BBSRC, gwnaethom ddarparu'r nodweddiad cyntaf o gyfansoddiad lipid SARS-CoV2, gan ddatgelu bilen gyfoethog ffosffolipid sy'n uchel mewn colesterol a gyda thua 50% o'r PE a PS wedi'i allanoli ar yr wyneb allanol (Saud et al). Mae gan y gwaith hwn oblygiadau i'n dealltwriaeth o sut mae'r feirws yn rhyngweithio â chelloedd cynnal i drosglwyddo haint. Gyda Maria Fedorova a'i chydweithwyr, gwnaethom gyhoeddi canllaw offeryn ar gyfer lipidomeg ar LIPID MAPS (Ni et al), a chyfrannodd at osod canllawiau rhyngwladol ar gyfer Lipidomeg trwy bapur canllaw (McDonald et al). Datgelodd sbectrometreg màs lawer o ceramidau newydd a oedd yn bresennol mewn croen a gafodd eu newid mewn soriasis (Tyrrell et al).
- Ni, Z, Wölk, M, Jukes, G, Mendivelso Espinosa, K, Ahrends, R, Aimo, L, Alvarez-Jarreta, J, Andrews, S, Pont, A, Clair, GC, Conroy, MJ, Kopczyinki, D, Korf, A, Lopez-Clavijo, AF, Malik, A, Miranda Ackerman, J, Molenaar, MR, O'Donovan, C, Pluskal, T, Shevchenko, A Slenter, D, Siuzdak, G, Kutmon, M, Tsugawa, H, Willighagen, EL, Xia, J, O'Donnell, VB and Fedorova, M. (2023) Arwain y dewis o feddalwedd gwybodeg ac offer ar gyfer cymwysiadau ymchwil biofeddygol lipidomeg. Dulliau Natur https://doi.org/10.1038/s41592-022-01710-0, 20 (2), 193-204
- McDonald, JG, Ejsing, CS, Kopczynski, D, Holčapek, M, Aoki, J, Arita, M, Arita, M, Baker, ES, Bertrand-Michel, J, Bowden, JA, Brügger, B, Ellis, SR, Fedorova, M, Griffiths, WG, Han, X, Hartler, J, Hoffmann, N, Koelmel, JP, Köfeler, HC, Mitchell, TW, O'Donnell, VB, Saigusa, D, Schwudke, D, Shevchenko, A, Ulmer, CZ, Wenk, MR, Witting, M, Wolrab, D, Xia, Y, Ahrends, R, Liebisch G, and Ekroos, K. (2022) Cyflwyno rhestr wirio adrodd lipidomeg. Metabolaeth Natur (sylw). https://doi.org/10.1038/s42255-022-00628-3
- Saud, Z, Tyrrell, VJ Protty, M, Statkute, E, Rubina, A, Bentley, K, White, D, Rodrigues, PDS, Murphy, RC, Köfeler, H, Griffiths, WJ, Alvarez-Jarreta, J, Newcombe, RG, Heyman, J, Pritchard, M, McLeod, RWJ, Arya, A, Lynch, CA, Owens, D, Buurma, NJ, O'Donnell, VB, Thomas, DW, Stanton, RJ. Mae'r amlen SARS-CoV2 yn datgelu lefelau uchel o lipidau pro-geulo a gellir ei anactifadu gan rinsiau llafar sy'n cynnwys surfactant yn COVID19 (2022) J Lipid Res (J Lipid Res 2022 Ebr 15; 100208. doi: 10.1016 / j.jlr.2022.100208)
- Misheva, M, Kotzamanis, K, Davies, L, Tyrrell, VJ, Rodrigues, PRRS, Benavides, GA, Hinz, C, Murphy, RC, Kennedy, P, Taylor, PR, Rosas, M, Jones, SA, Deshpande, S, Andrews, R, Czubala, MA, Gurney, M, Aldrovandi, M, M, Meckelmann, SW, Ghazal, P, Darley-Usmar, VM, White, D, O'Donnell, VB (2022) Rheolir metaboledd Oxylipin gan mitochondrial B ocsidiad yn ystod llid bacteriol. Nat Commun 13, 139 (2022).
- Tyrrell, VJ, Ali, F, Boeglin, WE, Andrews, R, Burston, J, Birchall, JC, Ingram, J, Murphy, RC, Piguet V, Brash AR, O'Donnell VB, Thomas CP. (2021) Dadansoddiad lipidomig a thrawsgrifiol o lwybr biosynthetig Linoleoyl-omega-Hydroxyceramide mewn briwiau psoriatig dynol J Lipid Res (Mehefin 22; 100094. doi: 10.1016 / j.jlr.2021.100094)
2017-2020
Yn ystod y tair blynedd diwethaf, gwnaethom ddangos bod eoxPL yn chwarae rôl reoleiddiol wrth ddatblygu ymlediad aortig abdomenol ac y gallant adfer diffygion haemostatig mewn amodau diffyg ffactor geulo. Gwnaethom hefyd ddangos metaboledd lysophospholipid wedi'i newid mewn ffurf etifeddol gyffredin o glefyd cardiofasgwlaidd. Drwy gydweithrediadau, cefnogom lawer o astudiaethau allanol ar rolau lipidau bioactif mewn clefyd llidiol. Mae meddalwedd a gynhyrchir yn ein labordy a ariennir gan ERC wedi'i ymgorffori yn y gyfres LIPID MAPS o offer ar gyfer dadansoddi data lipidomeg. Adnewyddwyd ein grant Rhaglen BHF yn 2020. Astudiaethau sy'n archwilio sut y gellid targedu lipidau ar gyfer anweithgarwch firaol yn COVID19 Dechreuwyd yn vitro ac in vivo mewn cydweithrediad â chydweithwyr yn y Sefydliad Ymchwil Imiwnedd Systemau. Gyda chydweithwyr LIPID MAPS, rydym wedi datblygu canllawiau newydd ar gyfer cyhoeddiadau cyfnodolion a chonfensiynau enwi lipidau.
- O'Donnell, VB, FitzGerald, GA, Murphy, RC, Liebisch, G, Dennis, EA, Quehenberger, O, Subramaniam, S, Wakelam, MJO (2020) Camau tuag at safonau adrodd lleiaf ar gyfer sbectrometreg màs lipidomeg mewn cyhoeddiadau ymchwil biofeddygol Cylchrediad: Genomeg a Meddygaeth Fanwl (yn y wasg)
- Alvarez-Jarreta, J, Fahy, E, O'Connor, A, Price, A, Benton, P, Siuzdak, G, Rodrigues, PRS, Hawksworth, JA, Valdivia-Garcia, M, Allen, SM, O'Donnell, VB (2020) Darganfyddwr LipidDarganfyddwr 2.0: biblinell wybodeg uwch ar gyfer ceisiadau darganfod lipidomeg Biowybodeg (yn y wasg), hefyd ar BioRxiv: https://doi.org/10.1101/2020.08.16.250878
- Ipsiez, N, Pickering, RJ, Rosas, M, Tyrrell, VJ, Davies, LC, Orr, SJ, Czubala, MA, Fathalla, D, Robertson, AAB, Bryant, CE, O'Donnell, VB, Taylor, PR (2020) Mae macroffagau preswyl meinwe yn atal rhyddhau IL-1beta trwy lwybr adweithiol prostanoid / IL-10. EMBO J (2020) 39: e103454
- Meckelmann, SW, Hawksworth, JI, Gwyn, D, Andrews, R, Rodrigues, P, O'Connor, A, Alvarez-Jarreta, J, Tyrrell, VJ, Hinz, C, Zhou, Y, Williams, J, Aldrovandi, M, Watkins, WJ, Engler, AJ, Lo Sardo, V, Slatter, DA, Allen, SM, Acharya, J, Mitchell, J, J, Cooper, J, Aoki, J, Kano, K, Humphries, SE, ac O'Donnell, VB. (2020) Dysregulation metabolig o'r echel lysophospholipid / autotaxin yn y cromosom 9p21 genynnau SNP rs10757274 cylchrediad: Genomeg a Meddygaeth Fanwl (https://doi.org/10.1161/CIRCGEN.119.002806)
- O'Donnell, VB, Thomas, D, Stanton, R, Maillard, JY, Murphy, RC, Jones, SA, Humphreys, I, Wakelam, MJO, Fegan, C, Wise, AS, Bosch, A, Stattar, SA Rôl bosibl rinsiau llafar sy'n targedu'r amlen lipid firaol mewn haint SARS-CoV-2. (2020) SWYDDOGAETH. https://doi.org/10.1093/function/zqaa002
- Dol, S, Freitas, FP, Shah, R, Costa da Silva, M, Ingold, I, Grocin, AG, Panzilius, E, Scheel, C, Mourao, A, Buday, K, Wanninger, J, V, V, Ignane, T, Mohana, V, Rehberg, M, Schepers, A, O'Donnell, VB, Aldrovandi, M, Kurz, A, Sauer, M, Sattler, M, Tate, EW, Proneth, B, Schmitz, W, Schulze, A, Popowicz, G, Pratt, D, Mae Friedmann Angeli, JP, Conrad, M (2019) FSP1 yn atalydd ferroptosis glutathione-annibynnol Natur doi: 10.1038 / s41586-019-1707-0
- Allen-Redpath, K, Aldrovandi, M, Lauder, S, Gketsopoulou, A. Tyrrell, VJ, Slatter, DA, Andrews, R, Watkins, WJ, Atkinson, G, McNeill, E, Gilfedder, A, Protty, M, Burston, J, Johnson, SRC, Rodrigues, PRS, Jones, DO, Lee, R, Handa, A, Channon, K, Obaji, S, Alvarez-Jarreta, J, Krönke, G, Ackermann, J, Jenkins, PV, Collins, PW ac O'Donnell, VB. (2019) Mae pilenni ffosffolipid yn gyrru datblygiad aneurysm aortig abdomenol trwy ysgogi gweithgaredd ffactor ceulo. Proc Natl Acad Sci, UDA 116 (16) 8038-8047 https://doi.org/10.1073/pnas.1814409116
- Dysgwr, DA, Percy, CL, Allen-Redpath, K, Gajsiewicz, J, Brooks, NJ, Clayton, A, Tyrrell, VJ, Lauder, SN, Watson, A, Dul, M, Garcia-Diaz, Y, Aldrovandi, M, Heurich, M, Hall, J, Morrissey, JH, Lacroix-Desmazes, S, Delignat, S, Jenkins, PV, Collins, PW ac O'Donnell, VB (2018) Mae ffosffolipidau ocsideiddio'n ensymatig yn adfer ffurfio ceuladau gwaed yng ndiffyg ffactor VIII trwy gefnogi gweithgareddau ffactor ar arwynebau bilen J Clin Invest Insight 3(6): e98459. https://doi.org/10.1172/jci.insight.98459
- O'Donnell, VB, Rossjohn, J, Wakelam, MJO (2018) signalau ffosffolipid mewn celloedd imiwnedd cynhenid. J Clin Buddsoddi 128(7): 2670-2679 https://doi.org/10.1172/JCI97944.
2007-2017
Ers 2007, mae ein grŵp wedi darganfod nifer fawr o lipidau a wnaed gan blatennau dynol, niwtroffiliaid a monocytes, trwy'r llwybrau lipoxygenase a cyclooxygenase. Rydym wedi dangos y gall y lipidau hyn gynhenid imiwnedd gan gynnwys hyrwyddo ceulo gwaed, signalau imiwnedd a gweithgareddau gwrthfacterol leukocytes. Maent yn perthyn i deuluoedd ffosffolipidau ocsidiedig ensymatically (eoxPL), ac mae eu cenhedlaeth uchel i'w gael mewn clefyd thrombotig dynol, tra bod eu diffyg yn arwain at ddiffygion gwaedu ac amddiffyniad rhag llid fasgwlaidd. Gwneir y gwaith hwn mewn cydweithrediad â'r Athro Peter Collins a Dr Vince Jenkins (UHW).
- Lauder, SN, Allen-Redpath, K, Slatter, DA, Aldrovandi, M, O'Connor, A, Farewell, D, Percy, CL, Molhoek, JE, Rannikko, S, Tyrrell, VJ, Ferla, S, Milne, GL, Poole, AW, Thomas, CP, Obaji, S., Taylor, PR, Jones, SA, de Groot, PG, Urbanus, RT, Horkko S, Uderhardt, S, Ackermann, J, Jenkins, PV, Brancale, A, A, Kroenke, G, Collins, PW ac O'Donnell, VB (2017) Mae rhwydweithiau lipidau pilen ocsidiedig enzymatically yn cefnogi calsiwm - ffactor geulo dibynnol sy'n rhwymo i gynnal hemostasis. Gwyddoniaeth Signalau Cyf. 10, Rhifyn 507, eaan2787, DOI: 10.1126 / scisignal.aan2787
- O'Connor, A, Brasher, C, Slatter, DA, Meckelmann, SW, Hawksworth, JI, Allen, SM, O'Donnell, VB. (2017), LipidFinder, llif gwaith cyfrifiadurol ar gyfer darganfod lipidau yn nodi eicosanoid-phosphoinositides newydd mewn platennau. J Clin Buddsoddi Insight 2(7): e91634. doi: 10.1172 / jci.insight.91634
- Slatter, DA, Aldrovandi, M, O'Connor, A, Allen, S, Brasher, C, Murphy, RC, Meckelmann, S, Ravi, S, Darley-Usmar, V ac O'Donnell, VB. (2016) Mae mapio'r lipidomau platennau dynol yn datgelu ffosffolipase cytosol A2 fel rheolydd bioenergetics mitochondrial yn ystod actifadu. Metaboledd Cell 23, 930-934, gyda sylwebaeth gan FitzGerald, GA, lipidomeg platennau dynol: amrywiad, delweddu, fflwcs a thanwydd. 23, 757-759
- Hammond VJ, Morgan, AH, Thomas, CP, Brown, S, Freeman, BA, Lloyd, CM, Davies, J, Bush, A, Levonen, AL, Kansanen, E, Villacorta, L, Chen, YE, Porter, N, Garcia Diaz, YM, Schopfer, FJ & O'Donnell, VB (2012) Cynhyrchir keto-ffosffolipidau newydd gan monocytau a macroffagau, a ganfyddir mewn ffibrosis systig ac actifadu derbynnydd activate proliferator-g. J Biol Chem 287, 41651–41666.
- O'Donnell, VB, Murphy, RC. Teuluoedd newydd o ffosffolipidau oxidized bioactif a gynhyrchir gan gelloedd imiwnedd: gweithredoedd adnabod a signalau. (2012) Gwaed 120, 1985-1992
- Clark, SR, Guy, CJ., Scurr, MJ, Thomas, CP, Coles, B., Roberts, G, Eberl, M., Jones, SA, Topley, N, Kotceha, S. and O'Donnell, VB (2011) Mae eicosanoidau esterified yn cael eu cynhyrchu'n ddifrifol gan 5-lipoxygenase mewn niwtroffiliaid dynol sylfaenol ac mewn heintiau dynol a murin. Gwaed 117, 2033-2043
1999-2007
Ar ôl cyrraedd Caerdydd, fe wnes i ddiffinio gyda fy nghydweithwyr sut y gall ocsidiad lipid sy'n cael ei gyfryngu gan ensymau fasgwlaidd reoli pwysedd gwaed yn vitro ac in vivo. Mae'r prif ganfyddiadau'n cynnwys dangos sut mae lipoxygenases cellog a cyclooxygenases yn bwyta'n catalytig ocsid nitrig gan arwain at vasoconstriction a sut mae niwtroffiliaid yn patrolio'r fasgwledd gan gynnal pwysedd gwaed trwy leddfu llid a achosir gan facteria.
- Morton, J., Coles, B., Wright, K., Gallimore, A., Morrow, JD, Terry, ES, Anning PB, Morgan, BP, Dioszeghy, V., Kuhn, H., Chaitidis, P, Hobbs, A., Jones, SA ac O'Donnell, VB. (2008) "Mae cylchredeg niwtroffiliaid yn cynnal pwysedd gwaed ffisiolegol trwy atal bacteria a mynegiant iNOS dibynnol IFNg yn fasgwledd llygod iach" Gwaed 111, 5187-94
- Anning, P.B, Coles, B., Wang, H., Morrow, JD, Dey, S.K, Marnett, L.J. ac O'Donnell, VB (2006) "Mae angen tynnu ocsid nitrig ar gyfer effeithiau hypertensive a phrothrombotig o ataliad COX-2 yn vivo. Gwaed 108, 4059-4062
- Williams, PD, Coffey, M.J., Coles, B., Sanchez, S., Morrow, J.D., Cockcroft, J.R., Lewis, M.J. ac O'Donnell, VB "Yn vivo aspirin mae ychwanegiad yn atal defnydd ocsid nitrig gan blatennau dynol." (2005) Gwaed 106, 2737-2743
- Coffey, M.J., Chumley, PS, Coles, B., Natarajan, R., Thimmalapura, P., Nowell, M., Kühn, H., Lewis, M.J., Freeman, B.A. ac O'Donnell, VB (2001) "Defnydd catalytig o Nitric Ocsid gan 12/15-Lipoxygenase: Atal Actifiad Cyclase Guanylate Hydawdol Monocyte." Proc. Natl. Acad. Sci. UDA 98, 8006-8011
1996-1999
Tra'n gweithio ym Mhrifysgol Alabama yn Birmingham, gweithiais gyda'r labordy Freeman i nodweddu sut mae llwybrau ocsid nitrig ac ocsideiddio lipid yn croestorri (a gyhoeddwyd yn JBC, Biocemeg), gan ddiffinio llwybrau biocemegol newydd i synthesis nitrolipid, a dangos bod gan lipidau hyn gamau gwrthlidiol cryf.
- O'Donnell, VB, Taylor, KP, Parthasarathy, S., Kühn, H., Koesling, D., Friebe, A., Bloodsworth, A., Darley-Usmar, VM a Freeman, B.A. (1999) "Mae 15-Lipoxygenase yn catalytically yn defnyddio ocsid nitrig ac yn amharu ar activation guanylate cyclase" J. Biol. Chem 274, 20083-20091
- O'Donnell, VB, Eiserich, JP, Darley-Usmar, VM, Chumley, P.H., Kirk, M., Barnes, S. a Freeman, BC (1999) Nitration o lipid annirlawn gan rywogaethau nitrogen adweithiol sy'n deillio o ocsid nitrig, peroxynitrite, nitrogen deuocsid, asid nitraidd a nitronium ion" Chem. Res. Toxicol. 12, 83-92
- Coles, B., Bloodsworth, A., Clark, SR, Lewis, M.J., Croes, PR, Freeman, B.A. ac O'Donnell, VB (2002) "Nitrolinoleate yn atal mynegeion lluosog o swyddogaeth nitrophil" Circ. Res 91, 375-381 (Golygyddol, Freedman, J. "Nitrated lipids, ddiffinio eu bioweithgaredd" (2002) Circ. Res. 91, 371-372)
- Coles, B., Bloodsworth, A., Eiserich, JP, Coffey, M.J., McLaughlin, R.M., Giddings, JC, Lewis, M.J., Haslam, R.J., Freeman, B.A. ac O'Donnell, VB (2002) "Mae nitrolinoleate yn atal actifadu platennau trwy esgusodi calsiwm mobileiddio ac ysgogi ffosfforyleiddiad ffosfforylation o ffosffoprotein ffosffohydraidd sy'n ysgogi vasodilator (VASP) trwy ddrychiad cAMP" J. Biol. Chem 277, 5832-5840
1990-1996
Astudiais ym Mhrifysgol Berne, y Swistir ar Gymrodoriaeth Marie Curie (1994-1996). Diffiniais fecanweithiau cenhedlaeth radical rhydd mitochondrial. Roedd fy PhD ym Mhrifysgol Bryste (1990-1993) yn canolbwyntio ar nodweddu gweithred ensymatig cyfansoddion iodoniwm fel atalyddion flavoenzyme a oedd yn cael eu datblygu fel asiantau gwrthlidiol. Canfûm fod y rhain yn atalyddion sy'n dibynnu ar drosiant, na ellir eu gwrthdroi sy'n ffurfio adducts cofalent gyda chyd-ffactorau flavin. Mae'r atalyddion hyn yn cynrychioli rhai o'r atalyddion NADPH oxidase a ddefnyddir fwyaf eang sy'n dal i gael eu defnyddio heddiw.
- O'Donnell, V.B., Smith, G.C.M. &Jones, O.T.G. (1994) "Cynnwys radicalau ffenyl mewn ataliad cyfansawdd iodonium o flavoenzymes". Ffarmacoleg Moleciwlaidd 46, 778-785
- O'Donnell, V.B., Tew, D.G., Jones, O.T.G., England, p.j. (1993) "Astudiaethau ar fecanwaith ataliol cyfansoddion iodoniwm gyda chyfeiriad arbennig at niwtrophil NADPH oxidase." Biochem. J. 290, 1, 41-49.
Addysgu
Gyda fy ngrŵp ymchwil, rwy'n cyfrannu at SSCs ar gyfer ein rhaglen MBBCh a phrosiectau UG ar gyfer myfyrwyr Ffarmacoleg Feddygol (BSc).
Rwy'n arweinydd modiwl ar gyfer y modiwl Imiwnomethodolegau yn ein MSc mewn Imiwnoleg.
Rwy'n fentor academaidd i fyfyrwyr UG yn y rhaglen MBBCh.
Bywgraffiad
Education:
1993 PhD Bristol University, Biochemistry
1990 BSc, University of Dublin, Trinity College, Human Nutrition and Dietetics
Anrhydeddau a dyfarniadau
Royal Society Wolfson Research Merit Awardee (2017)
ERC Advanced Investigator (2015-)
Honorary Professor, Faculty of Medicine, University of the Republic, Montevideo, since 2008.
Marie Curie Excellence Award (EU), Brussels, March 2008
Wellcome Trust University Award, Cardiff University, 2002-2007
Iron Bolt Award, Gordon Research Conference on Oxygen Radicals, 2004
Wellcome Trust RCD Fellow, Cardiff University, 1999-2002
Parker B Francis Pulmonary Fellow, University of Alabama at Birmingham, 1997-1999
European Union Marie Curie Fellow, University of Berne, Switzerland, 1995-1996
Aelodaethau proffesiynol
Arweinydd, Academia Europaea (2020-)
Arweinydd Grŵp Cyswllt, Sefydliad Babraham Caergrawnt (2020-2022)
Cymrawd yr Academi Gwyddorau Meddygol (2020-)
Cymrawd Cymdeithas Ddysgedig Cymru, Ebrill 2015 -
Aelod Cyswllt, UK DRI, UK Dementia Research Insitute (Hydref 2020-)
Athro Anrhydeddus, Cyfadran Meddygaeth, Prifysgol y Weriniaeth, Montevideo, ers 2008.
Pwyllgorau ac adolygu
Diweddar yn unig
-Aelod a Dirprwy Gadeirydd (ers 2023), Grŵp Llywio Amlafiachedd, Cyngor Ymchwil Meddygol / NIHR (2018-)
-Grŵp Llywio, Cynhadledd Ryngwladol ar Biowyddoniaeth Lipidau (ICBL) (2022-)
Grŵp Goruchwylio Strategol, UKBiobank (2022-)
-Aelod, Grŵp Cynghori ar Ddatblygu a Darganfod Ffisioleg Ymddiriedolaeth Wellcome (2022-2023)
-Grŵp Golygyddol Gweithredol, Swyddogaeth, Cymdeithas Ffisiolegol America, 2020-.
-Aelod, Panel Cyllid Offer Cyfalaf MRC, 2021-2023
-Aelod, Pwyllgor Adrannol ar gyfer Academi Gwyddorau Meddygol SC3) 2020-2023
-Aelod grŵp Rheolaeth ar gyfer y DU, ar gyfer Rhwydwaith Gweithredu COST yr UE, EpiLIPIDNET, cyd-ymgeisydd (O'Donnell)
Meysydd goruchwyliaeth
Biocemeg lipid
Ymchwil cardiofasgwlaidd
Imiwnoleg lipidau
Llid
Ymgysylltu
LIPID MAPS Database and Resource funded by Cardiff-led funding from Wellcome Trust
In 2016, the Wellcome Trust funded a £1.3M 5 yr initiative led by our group jointly with Babraham Institute, Cambridge, and University of California San Diego to fund continuation and further development of LIPID MAPS, the global online database and resource for lipid research (http://www.cardiff.ac.uk/news/view/380752-new-funding-boosts-lipidomics-research).