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Dr Philip Pallmann
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Philip Pallmann
Prif Gymrawd Ymchwil (Ystadegau) a Dirprwy Gyfarwyddwr Treialon Heintiau, Llid ac Imiwnedd
Ymchwil Canolfan Treialon
Trosolwyg
Rwy'n Brif Gymrawd Ymchwil yn y Ganolfan Ymchwil Treialon lle rwy'n gweithio fel ystadegydd meddygol ar ddylunio, cynnal, dadansoddi ac adrodd treialon rheoledig ar hap ac astudiaethau eraill sydd wedi'u cynllunio'n dda.
Mae fy nghefndir mewn ystadegau cymhwysol, ond rwy'n gweithio ar draws ystod eang o feysydd clinigol gan gynnwys heintiau, clefydau niwroddirywiol, ac iechyd poblogaeth, yn ogystal ag ar hyrwyddo methodoleg treialon clinigol, yn enwedig dulliau dylunio effeithlon fel dyluniadau addasol.
Rwy'n Ddirprwy Gyfarwyddwr yr Is-adran Heintiau, Llid ac Imiwnedd yn y Ganolfan Ymchwil Treialon.
Rwy'n cyd-arwain Gweithgor Dyluniadau Addasol Partneriaeth Ymchwil Methodoleg Treialon MRC-NIHR.
Rwy'n aelod o bwyllgorau cyllido MRC-NIHR Efficacy and Mechanism Evaluation (EME) a EME/HTA Postdoctoral Award .
Rwy'n Olygydd Cyswllt ar gyfer y cyfnodolyn Trials a adolygir gan gymheiriaid ac yn Gynghorydd Ystadegol ar gyfer The Lancet Child & Adolescent Health.
Cyhoeddiad
2026
- Jones, H. G. et al., 2026. Peri-operative percutaneous nerve blocks and catheters in major lower limb amputation: a systematic review with meta-analysis. European Journal of Vascular and Endovascular Surgery (10.1016/j.ejvs.2026.09.013)
- Hamilton, R. et al. 2026. Multi-centre randomised controlled feasibility trial with embedded process evaluation of a samba percussion intervention for people living with Parkinson’s disease: a protocol for the Sparky Samba trial. BMJ Open 16 (9) e114372. (10.1136/bmjopen-2025-114372)
- Kotecha, S. J. et al. 2026. Obstetric Bleeding Study UK (OBS UK): protocol for a stepped wedge cluster randomised trial investigating the clinical and cost-effectiveness of a maternity quality improvement programme to reduce excess bleeding and need for transfusion after childbirth. BMJ Open 16 e118723. (10.1136/bmjopen-2026-118723)
- Baas, S. et al., 2026. Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics. Clinical Trials (10.1177/17407745261468001)
- Westlake, D. et al. 2026. A cluster randomised controlled trial of Social Workers in Schools (SWIS) in England. Research on Social Work Practice 36 (5), pp.651-671. (10.1177/10497315251338227)
- Barry, T. D. et al. 2026. National TB cohort review evaluation: insights for control strategies in low-incidence settings. IJTLD Open 3 (6), pp.396-402. (10.5588/ijtldopen.26.0678)
- Sheppard, R. et al. 2026. Decision on optimal combinatorial therapies in immune-mediated inflammatory diseases using systems approaches (DocTIS): protocol for a single-arm, adaptive basket trial in rheumatoid and psoriatic arthritis. Rheumatology Advances in Practice 10 (2) rkag036. (10.1093/rap/rkag036)
- Todd, S. et al., 2026. Procalcitonin testing combined with NEWS2 evaluation compared with usual care based on NEWS2 for identification of sepsis and antibiotic initiation in the emergency department in England and Wales (PRONTO): a multicentre, randomised, controlled, open-label, phase 3 trial. The Lancet Respiratory Medicine 14 (5), pp.417-431. (10.1016/S2213-2600(25)00433-3)
- Young, H. et al. 2026. A Sexual health and healthy relationships intervention for Further Education (SaFE): a synopsis of results from a pilot cluster randomised controlled trial including an assessment of the feasibility of record linkage and a health economic analysis. Public Health Research 14 (6), pp.1-32. (10.3310/GJHY3724)
- Aslam, R. W. et al. 2026. Optimisation of a sexual health and healthy relationships intervention for Further Education in England and Wales (SaFE). Public Health Research 14 (6), pp.33-52. (10.3310/AHDP8546)
- Lee, K. M. et al., 2026. Clinical trial simulation: planning with the OCTAVE framework, implementation and validation principles. Statistics in Medicine 45 (6-7) e70449. (10.1002/sim.70449)
- Waldron, C. et al. 2026. MR-pro-adrenomedullin (MR-proADM) and host immune response biomarkers evaluation of procalcitonin-guided antibiotic duration in children with infection for stratification of effectiveness: the PRECISE study. Efficacy and Mechanism Evaluation 13 (4)(10.3310/GJEC0818)
- Prout, H. et al. 2026. Challenges in shared decision-making about major lower limb amputation: the PERCEIVE qualitative study. BMJ Open 16 e104407. (10.1136/bmjopen-2025-104407)
2025
- Euden, J. et al. 2025. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients: the PEACH mixed methods study. Health Technology Assessment 29 (52), pp.1-32. (10.3310/GGFF9393)
- Mossop, H. et al., 2025. Practical guidance for conducting high-quality and rapid interim analyses in adaptive clinical trials. BMC Medicine 23 528. (10.1186/s12916-025-04362-x)
- Ioakeimidis, V. et al. 2025. In vivo mapping of striatal neurodegeneration in Huntington's disease with Soma and Neurite Density Imaging. eLife 14 RP107661. (10.7554/eLife.107661.1)
- Harris, S. R. S. et al., 2025. Cost‐effectiveness of a personalised self‐management intervention for people living with long Covid: the LISTEN randomised controlled trial. Health Expectations 28 e70357. (10.1111/hex.70357)
- Robertson, D. S. et al., 2025. Confidence intervals for adaptive trial designs I: a methodological review. Statistics in Medicine 44 (18-19) e70174. (10.1002/sim.70174)
- Robertson, D. S. et al., 2025. Confidence intervals for adaptive trial designs II: case study and practical guidance. Statistics in Medicine 44 (18-19) e70202. (10.1002/sim.70202)
- Schroeder, E. et al., 2025. Family VOICE: family group conferencing for children and families: implementation, context and cost-effectiveness [Abstract]. Presented at: 2nd North American Conference on Integrated Care Calgary, Canada 15-17 October 2024. Vol. 25.Vol. 178. (10.5334/ijic.NACIC24178)
- Schroeder, E. et al., 2025. Economic evaluation of a school-based social worker intervention (SWIS) [Abstract]. Presented at: 2nd North American Conference on Integrated Care Calgary, Canada 15-17 October 2024. Vol. 25.Vol. 060. (10.5334/ijic.NACIC24060)
- Henley, J. et al. 2025. Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sources. BMJ Open 15 e093210. (10.1136/bmjopen-2024-093210)
- Waldron, C. et al. 2025. Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT. Health Technology Assessment 29 (16)(10.3310/MBVA3675)
- Rai, T. et al., 2025. Managing obstetric bleeding in Wales: a qualitative evaluation of the OBS Cymru care bundle using normalisation process theory. PLoS One 20 (4) e0320754. (10.1371/journal.pone.0320754)
- Ioakeimidis, V. et al. 2025. In vivo mapping of striatal microstructure in Huntington's disease with Soma and Neurite Density Imaging. MedRXiv (10.1101/2025.03.17.25324107)
- Waldron, C. et al. 2025. Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. The Lancet Child & Adolescent Health 9 (2), pp.121-130. (10.1016/S2352-4642(24)00306-7)
- Bell, S. F. et al. 2025. Relationship between the dual platelet‐inhibited ROTEM ® Sigma FIBTEM assay and Clauss fibrinogen during postpartum haemorrhage. Anaesthesia: Peri-operative medicine, critical care and pain 80 (1), pp.104-106. (10.1111/anae.16455)
- Busse-Morris, M. et al. 2025. Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial): pragmatic, multicentre, parallel group, randomised controlled trial. BMJ Medicine 4 (1) e001068. (10.1136/bmjmed-2024-001068)
- Naseem, R. et al., 2025. Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection. NIHR Open Research 4 35. (10.3310/nihropenres.13568.2)
2024
- Williams-Thomas, R. et al. 2024. Sexual health and healthy relationships for Further Education (SaFE) in Wales and England: results from a pilot cluster randomised controlled trial. BMJ Open 14 e091355. (10.1136/bmjopen-2024-091355)
- Barry, T. D. et al. 2024. The role of nurses in national TB control programs: qualitative insights from TB cohort review in Wales. Medical Research Archives 12 (12)(10.18103/mra.v12i12.6063)
- Sandoe, J. A. T. et al., 2024. A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19. Journal of Antimicrobial Chemotherapy 79 (11), pp.2792-2800. dkae246. (10.1093/jac/dkae246)
- Schroeder, E. et al., 2024. The cost-effectiveness and cost-consequences of a school-based social worker intervention: a within-trial economic evaluation. Children and Youth Services Review 166 107928. (10.1016/j.childyouth.2024.107928)
- Robertson, D. S. et al., 2024. Confidence intervals for adaptive trial designs I: a methodological review. arXiv 2411.08495. (10.48550/arXiv.2411.08495)
- Robertson, D. S. et al., 2024. Confidence intervals for adaptive trial designs II: case study and practical guidance. arXiv 2411.08771. (10.48550/arXiv.2411.08771)
- Jarvis, R. C. et al., 2024. Development and preliminary validation of a diagnostic prediction model to optimise outpatient management of patients with urolithiasis using Urinary Stones and Intervention Quality of Life (USIQoL) measure. Quality of Life Research 33 , pp.2809–2818. (10.1007/s11136-024-03733-w)
- Bennett, V. et al. 2024. Student perspectives on school-based social workers: A mixed-methods study. Journal of Children's Services 19 (3), pp.189-221. (10.1108/JCS-04-2023-0021)
- Smith, E. E. et al., 2024. Comment on: "Integrating human intuition into prediction algorithms for improved surgical risk stratification". Annals of Surgery Open 5 (3) e485. (10.1097/AS9.0000000000000485)
- Elsmore, A. et al., 2024. The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research. Trials 25 629. (10.1186/s13063-024-08487-x)
- Drew, C. et al. 2024. F081 A naturalistic assessment of lifestyle in Huntington’s disease; results from the DOMINO-HD study. Journal of Neurology, Neurosurgery and Psychiatry 95 A103. (10.1136/jnnp-2024-EHDN.199)
- Drew, C. et al. 2024. J025 Establishing feasibility for cell replacement therapy - outcomes from the trident (trial designs for delivery of novel therapies for neurodegeneration) trial [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 95 (S1) A170. (10.1136/jnnp-2024-EHDN.346)
- Webb, E. J. D. et al., 2024. The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study. Journal of Antimicrobial Chemotherapy 79 (8), pp.1831-1842. dkae167. (10.1093/jac/dkae167)
- Deere, R. et al. 2024. Multi-domain self-management in older people with osteoarthritis and multimorbidities: protocol for the TIPTOE randomised controlled trial. Trials 25 557. (10.1186/s13063-024-08380-7)
- Ioakeimidis, V. et al. 2024. Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease. BMJ Open 14 (7) e082161. (10.1136/bmjopen-2023-082161)
- Wood, S. et al. 2024. Family group conference provision in UK local authorities and associations with children looked after rates. The British Journal of Social Work 54 (5), pp.2045-2066. (10.1093/bjsw/bcae019)
- Naseem, R. et al., 2024. Mapping decision-making pathways: determination of intervention entry points for diagnostic tests in suspected serious infection. NIHR Open Research 4 35. (10.3310/nihropenres.13568.1)
- Scourfield, J. et al. 2024. Family group conferencing for children and families: Evaluation of implementation, context and effectiveness (Family VOICE). Study protocol. PLoS ONE 19 (6) e0300834. (10.1371/journal.pone.0300834)
- Webb, E. J. D. et al., 2024. Evidence of quality of life for hospitalised patients with COVID-19: a scoping review. Health Technology Assessment 29 (52), pp.33-56. (10.3310/ATPR4281)
- Schroeder, E. et al., 2024. The cost-effectiveness and cost-consequences of a school-based social worker intervention: a within-trial economic evaluation. SSRN 4776734. (10.2139/ssrn.4776734)
- Gwilym, B. L. et al. 2024. Long-term risk prediction after major lower limb amputation: 1-year results of the PERCEIVE study. BJS Open 8 (1) zrad135. (10.1093/bjsopen/zrad135)
- Kumwenda, M. et al., 2024. Identifying critically ill children in Malawi: A modified qSOFA score for low-resource settings. PLOS Global Public Health 4 (1) e0002388. (10.1371/journal.pgph.0002388)
2023
- Dimairo, M. et al., 2023. A practical adaptive designs toolkit: making adaptive designs more accessible. Presented at: Society for Clinical Trials 44th Annual Meeting Baltimore 21-24 May 2023. Vol. 20.Vol. CP7-2. SAGE Publications. , pp.37-37. (10.1177/17407745231210703)
- Henley, J. et al. 2023. Developing a model for decision-making around antibiotic prescribing for patients with COVID-19 pneumonia in acute NHS hospitals during the first wave of the COVID-19 pandemic: Qualitative results from the Procalcitonin Evaluation of Antibiotic use in COVID-19 Hospitalised patients (PEACH Study). BMJ Open 13 (12) e077117. (10.1136/bmjopen-2023-077117)
- Ioakeimidis, V. et al. 2023. Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington's disease. [Online].medRxiv: medRxiv. (10.1101/2023.11.15.23298581)Available at: https://doi.org/10.1101/2023.11.15.23298581.
- Metzler-Baddeley, C. et al. 2023. HD-DRUM, a tablet-based drumming training App intervention for people with Huntington Disease: App development study. Journal of Medical Internet Research 2023 (7) e48395. (10.2196/48395)
- Law, M. et al., 2023. Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing. Trials 24 640. (10.1186/s13063-023-07576-7)
- Markoulidakis, A. et al. 2023. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology 23 , pp.115-148. (10.1007/s10742-022-00280-0)
- Robertson, D. S. et al., 2023. Point estimation for adaptive trial designs II: practical considerations and guidance. Statistics in Medicine 42 (14), pp.2496-2520. (10.1002/sim.9734)
- Karanja, J. , Pallmann, P. and Poehling, H. 2023. Systemic slow-release neem formulations: the future of cabbage aphids, Brevicoryne brassicae control. Open Access Library Journal 10 e10158. (10.4236/oalib.1110158)
- Schoenbuchner, S. M. et al. 2023. Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials 24 (1) 364. (10.1186/s13063-022-06956-9)
- Metzler-Baddeley, C. et al. 2023. Applying an integrated knowledge translation framework approach to develop a tablet-based rhythmic movement training intervention for people with Huntington’s disease. [Online].JMIR Preprints. (10.2196/preprints.48395)Available at: https://preprints.jmir.org/preprint/48395.
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24 75. (10.1186/s13063-023-07090-w)
- Adara, L. et al. 2023. The Social Workers in Schools Trial: An evaluation of school based social work.. Project Report.Early Intervention Foundation.
2022
- Gwilym, B. L. et al., 2022. Short-term risk prediction after major lower limb amputation: PERCEIVE study. BJS Open 109 (12), pp.1300-1311. (10.1093/bjs/znac309)
- Lenihan, R. A. F. et al., 2022. Mid-regional pro-adrenomedullin in combination with pediatric early warning scores for risk stratification of febrile children presenting to the emergency department: secondary analysis of a nonprespecified United Kingdom cohort study. Pediatric Critical Care Medicine 23 (12), pp.980-989. (10.1097/PCC.0000000000003075)
- Wood, S. et al. 2022. A UK-wide survey of family group conference provision. Project Report.Cardiff: CASCADE.
- Kumwenda, M. et al., 2022. Identifying critically ill children at risk of dying during hospital admission in Malawi: prognostic accuracy of a modified qSOFA score for low-resource settings. Presented at: 11th World Congress on Pediatric Intensive and Critical Care Virtual 12-16 July 2022. Vol. 23.Vol. OP044. (10.1097/01.pcc.0000899856.14238.94)
- Llewelyn, M. J. et al., 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data - authors' response. Journal of Antimicrobial Chemotherapy 77 (11), pp.3211-3212. dkac315. (10.1093/jac/dkac315)
- Robertson, D. S. et al., 2022. Point estimation for adaptive trial designs I: A methodological review. Statistics in Medicine (10.1002/sim.9605)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH): protocol for a retrospective observational study. Methods and Protocols 5 (6) 95. (10.3390/mps5060095)
- Markoulidakis, A. et al. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September. Vol. 93.Vol. S1. (10.1136/jnnp-2022-ehdn.111)
- Markoulidakis, A. et al. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93 (S1) A44. (10.1136/jnnp-2022-ehdn.114)
- Metzler-Baddeley, C. et al. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting Bologna, Italy 16-18 September 2022. Vol. 93.Vol. S1. , pp.A100-A101. (10.1136/jnnp-2022-ehdn.267)
- Love, S. B. et al., 2022. Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units. Trials 23 757. (10.1186/s13063-022-06680-4)
- Westlake, D. et al. 2022. Evaluating a school-based intervention through routine local authority data and national school data: challenges and opportunities. Presented at: International Population Data Linkage Conference 2022 7 - 9 September 2022. Vol. 7.Vol. 3. (10.23889/ijpds.v7i3.1886)
- Wason, J. M. S. et al., 2022. Practical guidance for planning resources required to support publicly‑funded adaptive clinical trials. BMC Medicine 20 254. (10.1186/s12916-022-02445-7)
- Chatoo, S. A. et al., 2022. Antibiotic prescribing in hospitalized patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review. Presented at: BSAC Spring Conference 2022 10 - 11 May 2022. Vol. 4.Vol. S.2. (10.1093/jacamr/dlac053.012)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6 (6) e36870. (10.2196/36870)
- Euden, J. et al. 2022. PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open 12 (6) e063424. (10.1136/bmjopen-2022-063424)
- Westlake, D. et al. 2022. The SWIS trial: protocol of a pragmatic cluster randomised controlled trial of school based social work. PLoS ONE 17 (6) e0265354.. (10.1371/journal.pone.0265354)
- Llewelyn, M. J. et al., 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data. Journal of Antimicrobial Chemotherapy 77 (4), pp.1189-1196. (10.1093/jac/dkac017)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study. Presented at: Infection 2021: BSAC Winter Conference Virtual 9-10 December 2021. Vol. 4.Vol. 1. (10.1093/jacamr/dlac004.013)
- Waldron, C. et al. 2022. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial. BMJ Open 12 (1) e047490. (10.1136/bmjopen-2020-047490)
- Milosevic, S. et al. 2022. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation: a collaboratiVE study (PERCEIVE)—protocol for the PERCEIVE qualitative study. BMJ Open 12 (1) e053159. (10.1136/bmjopen-2021-053159)
- Dimairo, M. et al., 2022. PANDA: a practical adaptive and novel designs and analysis toolkit. [Online].University of Sheffield. Available at: https://panda.shef.ac.uk/.
- Powell, E. et al., 2022. Introduction of standardized, cumulative quantitative measurement of blood loss into routine maternity care. Journal of Maternal-Fetal and Neonatal Medicine 35 (8), pp.1491-1497. (10.1080/14767058.2020.1759534)
2021
- Markoulidakis, A. et al. 2021. CoBWeb: a user-friendly web application to estimate causal treatment effects from observational data using multiple algorithms. arXiv
- Gwilym, B. L. et al., 2021. The PERCEIVE quantitative study: PrEdiction of Risk and Communication of outcome following major lower-limb amputation: protocol for a collaboratiVE study. BJS Open 5 (6) zrab118. (10.1093/bjsopen/zrab118)
- Richards, O. et al., 2021. Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS. Antibiotics 10 (11) 1425. (10.3390/antibiotics10111425)
- Wilson, N. et al., 2021. Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine 19 251. (10.1186/s12916-021-02124-z)
- Markoulidakis, A. et al. 2021. Examining the effect of exercise on the progression and severity of Huntington's disease using different covariate balancing methods and simulated data derived from the PACE-HD study [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 92 (Sup1), pp.A31. (10.1136/jnnp-2021-EHDN.74)
- Preece, R. et al., 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62 (1), pp.127-135. (10.1016/j.ejvs.2021.02.038)
- Romaine, S. T. et al., 2021. Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study. BMJ Open 11 (5) e044091. (10.1136/bmjopen-2020-044091)
- Robertson, D. S. et al., 2021. Point estimation for adaptive trial designs. arXiv
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. BMC Pregnancy and Childbirth 21 377. (10.1186/s12884-021-03853-y)
- Powell, N. et al., 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10 (5) 516. (10.3390/antibiotics10050516)
- Gwilym, B. et al., 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study [Poster]. BJS Open 5 (Sup1), pp.i25. zrab032.089. (10.1093/bjsopen/zrab032.089)
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study (October 11, 2020). SSRN (10.2139/ssrn.3746928)
- Wheeler, M. , Powell, E. and Pallmann, P. 2021. Use of high-fidelity simulation training for radiology healthcare professionals in the management of acute medical emergencies. British Journal of Radiology 94 (1117) 20200520. (10.1259/bjr.20200520)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3 (1) fcaa230. (10.1093/braincomms/fcaa230)
- Markoulidakis, A. et al. 2021. How balance and sample size impact bias in the estimation of causal treatment effects: a simulation study. arXiv 2107.09009.
2020
- Burnett, T. et al., 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. BMC Medicine 18 352. (10.1186/s12916-020-01808-2)
- Romaine, S. T. et al., 2020. Accuracy of a modified qSOFA score for predicting critical care admission in febrile children. Pediatrics 146 (4) e20200782. (10.1542/peds.2020-0782)
- Dimairo, M. et al., 2020. The Adaptive designs CONSORT Extension (ACE) Statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ 369 m115. (10.1136/bmj.m115)
- Dimairo, M. et al., 2020. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21 528. (10.1186/s13063-020-04334-x)
- Parkes, M. et al., 2020. Futility of the treatment, rather than futility of the trial, as the primary focus of interim analyses in clinical trials. Presented at: Society for Clinical Trials (SCT) 40th Annual Meeting New Orleans, LA, US 19-22 May 2019. Vol. 17.Vol. 1_Supp. SAGE Publications (UK and US). , pp.62. (10.1177/1740774520907457)
- Pallmann, P. et al. 2020. Designing and evaluating dose-escalation studies made easy: the MoDEsT web app. Clinical Trials 17 (2), pp.147-156. (10.1177/1740774519890146)
- Burnett, T. et al., 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. [Online].arXiv. Available at: https://arxiv.org/abs/2006.12811.
- Markoulidakis, A. et al. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online].arXiv. Available at: https://arxiv.org/abs/2010.09563.
2019
- Dimairo, M. et al., 2019. Introducing the Adaptive designs CONSORT Extension (ACE) Statement to improve reporting of randomised trials that use an adaptive design (P-7). Presented at: 5th International Clinical Trials Methodology Conference (ICTMC 2019) Brighton, UK 6-9 October 2019. BioMed Central(10.1186/s13063-019-3688-6)
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2018
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2017
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2016
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2015
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2014
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2013
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2012
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- Markoulidakis, A. et al. 2021. Examining the effect of exercise on the progression and severity of Huntington's disease using different covariate balancing methods and simulated data derived from the PACE-HD study [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 92 (Sup1), pp.A31. (10.1136/jnnp-2021-EHDN.74)
- Preece, R. et al., 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62 (1), pp.127-135. (10.1016/j.ejvs.2021.02.038)
- Romaine, S. T. et al., 2021. Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study. BMJ Open 11 (5) e044091. (10.1136/bmjopen-2020-044091)
- Robertson, D. S. et al., 2021. Point estimation for adaptive trial designs. arXiv
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. BMC Pregnancy and Childbirth 21 377. (10.1186/s12884-021-03853-y)
- Powell, N. et al., 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10 (5) 516. (10.3390/antibiotics10050516)
- Gwilym, B. et al., 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study [Poster]. BJS Open 5 (Sup1), pp.i25. zrab032.089. (10.1093/bjsopen/zrab032.089)
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study (October 11, 2020). SSRN (10.2139/ssrn.3746928)
- Wheeler, M. , Powell, E. and Pallmann, P. 2021. Use of high-fidelity simulation training for radiology healthcare professionals in the management of acute medical emergencies. British Journal of Radiology 94 (1117) 20200520. (10.1259/bjr.20200520)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3 (1) fcaa230. (10.1093/braincomms/fcaa230)
- Markoulidakis, A. et al. 2021. How balance and sample size impact bias in the estimation of causal treatment effects: a simulation study. arXiv 2107.09009.
- Burnett, T. et al., 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. BMC Medicine 18 352. (10.1186/s12916-020-01808-2)
- Romaine, S. T. et al., 2020. Accuracy of a modified qSOFA score for predicting critical care admission in febrile children. Pediatrics 146 (4) e20200782. (10.1542/peds.2020-0782)
- Dimairo, M. et al., 2020. The Adaptive designs CONSORT Extension (ACE) Statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ 369 m115. (10.1136/bmj.m115)
- Dimairo, M. et al., 2020. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21 528. (10.1186/s13063-020-04334-x)
- Pallmann, P. et al. 2020. Designing and evaluating dose-escalation studies made easy: the MoDEsT web app. Clinical Trials 17 (2), pp.147-156. (10.1177/1740774519890146)
- Hornbacher, J. et al., 2019. The levels of sulfur-containing metabolites in Brassica napus are not influenced by the circadian clock but diurnally. Journal of Plant Biology 62 (5), pp.359-373. (10.1007/s12374-019-0143-x)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5 (1) 87. (10.1186/s40814-019-0474-x)
- Jansen, J. O. et al., 2019. Bayesian clinical trial designs another option for trauma trials? Erratum. Journal of Trauma and Acute Care Surgery 86 (4), pp.760. (10.1097/TA.0000000000002236)
- Jaki, T. , Pallmann, P. and Magirr, D. 2019. The R package MAMS for designing multi-arm multi-stage clinical trials. Journal of Statistical Software 88 (4)
- Dimairo, M. et al., 2018. Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine 16 (1) 210. (10.1186/s12916-018-1196-2)
- Pallmann, P. , Ritz, C. and Hothorn, L. A. 2018. Simultaneous small-sample comparisons in longitudinal or multi-endpoint trials using multiple marginal models. Statistics in Medicine 37 (9), pp.1562-1576. (10.1002/sim.7610)
- Pallmann, P. et al. 2018. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine 16 29. (10.1186/s12916-018-1017-7)
- Pallmann, P. and Jaki, T. 2017. Simultaneous confidence regions for multivariate bioequivalence. Statistics in Medicine 36 (29), pp.4585-4603. (10.1002/sim.7446)
- Pallmann, P. , Pretorius, M. and Ritz, C. 2017. Simultaneous comparisons of treatments at multiple time points: Combined marginal models versus joint modeling. Statistical Methods in Medical Research 26 (6), pp.2633-2648. (10.1177/0962280215603743)
- Jansen, J. O. et al., 2017. Bayesian clinical trial designs: Another option for trauma trials?. Journal of Trauma and Acute Care Surgery 83 (4), pp.736-741. (10.1097/TA.0000000000001638)
- Parkes, M. et al., 2017. The two-stage treatment selection (TSTS) design: a novel approach to treatment selection in clinical trials. Trials 18 (S1), pp.166. P440. (10.1186/s13063-017-1902-y)
- Otieno, J. A. , Pallmann, P. and Poehling, H. 2017. Additive and synergistic interactions amongst Orius laevigatus (Heteroptera: Anthocoridae), entomopathogens and azadirachtin for controlling western flower thrips (Thysanoptera: Thripidae). BioControl 62 (1), pp.85-95. (10.1007/s10526-016-9767-7)
- Pallmann, P. 2017. Sample size determination in clinical trials with multiple endpoints. T. Sozu, R. Sugimoto, T. Hamasaki, and S. R. Evans (2015). New York, NY: Springer. 95 pages, ISBN: 978-3-319-22004-8. Biometrical Journal 59 (1), pp.218. (10.1002/bimj.201600135)
- Rumlow, A. et al., 2016. Quantitative expression analysis in brassica napus by northern blot analysis and reverse transcription-quantitative PCR in a complex experimental setting. PLoS ONE 11 (9) e0163679. (10.1371/journal.pone.0163679)
- Pallmann, P. and Hothorn, L. A. 2016. Boxplots for grouped and clustered data in toxicology. Archives of Toxicology 90 (7), pp.1631-1638. (10.1007/s00204-015-1608-4)
- Otieno, J. A. , Pallmann, P. and Poehling, H. -. 2016. The combined effect of soil-applied azadirachtin with entomopathogens for integrated management of western flower thrips. Journal of Applied Entomology 140 (3), pp.174-186. (10.1111/jen.12242)
- Pallmann, P. and Hothorn, L. A. 2016. Analysis of means: a generalized approach using R. Journal of Applied Statistics 43 (8), pp.1541-1560. (10.1080/02664763.2015.1117584)
- Pallmann, P. and Schaarschmidt, F. 2016. Common pitfalls when testing additivity of treatment mixtures with chi-square analyses. Journal of Applied Entomology 140 (1-2), pp.135-141. (10.1111/jen.12258)
- Pallmann, P. 2015. Simultaneous Statistical Inference: With Applications in the Life Sciences. T.Dickhaus (2014). Heidelberg: Springer. 180 pages, ISBN: 978-3-642-45181-2.. Biometrical Journal 57 (6), pp.1151-1152. (10.1002/bimj.201500129)
- Pallmann, P. 2015. Analyzing baseball data with R [book review]. Journal of the Royal Statistical Society Series A (Statistics in Society) 178 (4), pp.1099-1099. (10.1111/rssa.3_12138)
- Karanja, J. , Poehling, H. and Pallmann, P. 2015. Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter, in the control of whiteflies, aleyrodes proletella and trialeurodes vaporariorum (hemiptera: aleyrodidae). Journal of Economic Entomology 108 (3), pp.1182-1190. (10.1093/jee/tov047)
- Weese, A. et al., 2015. Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack. Frontiers in Plant Science 6 9. (10.3389/fpls.2015.00009)
- Pallmann, P. , Hothorn, L. A. and Djira, G. D. 2014. A Levene-type test of homogeneity of several variances against ordered alternatives. Computational Statistics 29 , pp.1593-1608. (10.1007/s00180-014-0508-z)
- Pallmann, P. 2014. Applied meta-analysis with R. Journal of Applied Statistics 42 (4), pp.914-915. (10.1080/02664763.2014.989464)
- Jaki, T. , Pallmann, P. and Wolfsegger, M. J. 2013. Authors' reply to Comments on 'Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs'. Statistics in Medicine 32 (30), pp.5487-5488. (10.1002/sim.6000)
- Jaki, T. , Pallmann, P. and Wolfsegger, M. J. 2013. Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs. Statistics in Medicine 32 (30), pp.5469-5483. (10.1002/sim.5886)
- Pallmann, P. et al. 2012. Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices. Molecular Ecology Resources 12 (6), pp.1068-1078. (10.1111/1755-0998.12004)
Gwefannau
- Ioakeimidis, V. et al. 2023. Protocol for a randomised controlled feasibility trial of HD-DRUM, a rhythmic movement training application for cognitive and motor symptoms in people with Huntington's disease. [Online].medRxiv: medRxiv. (10.1101/2023.11.15.23298581)Available at: https://doi.org/10.1101/2023.11.15.23298581.
- Metzler-Baddeley, C. et al. 2023. Applying an integrated knowledge translation framework approach to develop a tablet-based rhythmic movement training intervention for people with Huntington’s disease. [Online].JMIR Preprints. (10.2196/preprints.48395)Available at: https://preprints.jmir.org/preprint/48395.
- Dimairo, M. et al., 2022. PANDA: a practical adaptive and novel designs and analysis toolkit. [Online].University of Sheffield. Available at: https://panda.shef.ac.uk/.
- Burnett, T. et al., 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. [Online].arXiv. Available at: https://arxiv.org/abs/2006.12811.
- Markoulidakis, A. et al. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online].arXiv. Available at: https://arxiv.org/abs/2010.09563.
Monograffau
- Adara, L. et al. 2023. The Social Workers in Schools Trial: An evaluation of school based social work.. Project Report.Early Intervention Foundation.
- Wood, S. et al. 2022. A UK-wide survey of family group conference provision. Project Report.Cardiff: CASCADE.
Ymchwil
Crynodeb o'm hymchwil
Ar hyn o bryd rwy'n gweithio ar nifer o dreialon clinigol (CLARITY, DocTIS, HD-DRUM, OBS UK, PLACEMENT, SaFE, SParky Samba, TIPTOE, VALTIVE-C) ac astudiaethau arsylwadol (Family VOICE). Mae astudiaethau blaenorol yr wyf wedi gweithio arnynt yn cynnwys BATCH, DOMINO-HD, FLAME, LISTEN, PEACH, PERCEIVE, PRECISE, PRONTO, PROTECT (prif ymchwilydd), SaFE, SWIS, TAPERS, a TRIDENT.
Rwyf wedi bod yn rhan weithredol o'r Prosiect ACE i ddatblygu estyniad CONSORT swyddogol ar gyfer treialon clinigol gyda dyluniad addasol, y Prosiect PANDA i greu platfform addysgol ar-lein am ddyluniadau addasol, y Prosiect CAT i ddatblygu canllawiau costio arfer gorau ar gyfer CTUs sy'n cefnogi treialon dylunio addasol, a'r Prosiect ROBIN i ddatblygu canllawiau arfer gorau ar gyfer cynnal dadansoddiadau interim mewn treialon cyfnod hwyr.
Rwyf hefyd yn ymwneud â nifer o brosiectau cymrodoriaeth gan gynnwys fel cydweithredwr a ariennir ar Gymrodoriaeth Uwch HCRW/NIHR Claudia Metzler-Baddeley, fel cynghorydd ar Gymrodoriaeth Datblygu Gyrfa CRUK Haiyan Zheng, ac fel cyd-oruchwyliwr ar Gymrodoriaeth Cyn-ddoethurol NIHR Joseph Caldwell.
Rwyf wedi (cyd-)awdur a / neu gynhaliwr nifer o becynnau R sydd ar gael yn rhad ac am ddim ar CRAN, gan gynnwys MAMS (astudiaethau aml-gam aml-fraich), BayesMAMS (astudiaethau aml-gam aml-fraich Bayesian), jocre (rhanbarthau hyder ar y cyd), cymedrol (treialon cynyddu dos yn seiliedig ar fodel), ANOM (dadansoddiad o gymedr), a simboot (casgliad ar y pryd ar gyfer mynegeion amrywiaeth).
Rhwng 2017 a 2023 roeddwn yn Ddirprwy Gyfarwyddwr y Gwasanaeth Dylunio a Chynnal Ymchwil (RDCS) ar gyfer De-ddwyrain Cymru, a weithiodd gyda staff y GIG a gofal cymdeithasol i ddatblygu ceisiadau cyllid o ansawdd uchel ar gyfer prosiectau ymchwil arloesol ym maes iechyd a gofal cymdeithasol.
Cyllid grant a ddyfarnwyd yn ddiweddar
2026
- NIHR PHR: SaFE: treial ar hap o ymyrraeth iechyd rhywiol a pherthnasoedd ar gyfer addysg bellach (£2,004,726)
2024
- JGGF NRG: Gwerthuso dichonoldeb ymyrraeth taro samba ar gyfer pobl â chlefyd Parkinson (SParky Samba) (£360,881)
2023
- NIHR HTA: Treial ar hap sy'n archwilio clinigol a chost-effeithiolrwydd tri chyfundrefn antithrombotig yn dilyn ailfasgwlareiddio aelodau isaf endofasgwlaidd ar gyfer ischemia cronig sy'n bygwth aelodau: CLARITY (clopidogrel, aspirin a rivaroxaban ar ôl ailfasgwlareiddio gydag angioplasti) (£2,575,967)
- NIHR HTA: Gwerthusiad ar hap o ganlyniadau clinigol gan ddefnyddio technolegau newydd i wneud y gorau o therapi gwrthficrobaidd (PROTECT) (£204,987, Prif Ymchwilydd)
2022
- NIHR HSDR: Clinigol a chost-effeithiolrwydd rhaglen gwella ansawdd mamolaeth i leihau gwaedu gormodol a'r angen am drallwyso ar ôl genedigaeth: treial ar hap clwstwr lletem cam astudiaeth obstetreg y DU (OBS UK) (£3,650,790)
- NIHR HTA: Hunanreolaeth aml-barth mewn pobl hŷn ag osteoarthritis ac aml-afiachusrwydd (TIPTOE) (£1,711,355)
- Cyllid Cymorth CTU NIHR: Interims cadarn ar gyfer dyluniadau addasol (ROBIN): datblygu arfer gorau ar gyfer dadansoddiadau interim o ansawdd uchel a chyflym mewn treialon cam II-IV (£71,238)
- NIHR HTA: Cathhetr anesthetig lleol perineural ar ôl amputation mawr yr aelodau isaf (PLACEMENT) (£1,635,918)
2021
- Galwad COVID Hir NIHR: Cymorth hunanreoli wedi'i bersonoli COVID hir – cyd-ddylunio a gwerthuso (LISTEN) (£1,055,520)
- NIHR HS&DR: Cynadledda grŵp teuluol i blant a theuluoedd: gwerthusiad o weithredu, cyd-destun ac effeithiolrwydd (Family VOICE) (£1,194,736)
2020
- NIHR HTA: Procalcitonin: gwerthusiad o'r defnydd o wrthfiotigau mewn cleifion COVID-19 yn yr ysbyty (PEACH) (£731,858)
- HCRW RfPPB: PERCEIVE: rhagfynegi risg a chyfathrebu'r canlyniad ar ôl amputation mawr ar aelodau isaf – astudiaeth gydweithredol (£229,225)
- DfE WWCSC: Gweithwyr cymdeithasol mewn ysgolion (SWIS) (£385,597)
- NIHR EME: Gwerthusiad MR-pro-adrenomedullin (MR-proADM) ac ImmunoXpert o hyd gwrthfiotigau dan arweiniad procalcitonin mewn plant â haint ar gyfer haenu effeithiolrwydd (PRECISE) (£385,450)
2019
- Cyllid Seilwaith CTU HCRW: Canolfan Ymchwil Treialon 2020-23 (£2,470,489)
- Cyllid Cymorth CTU NIHR: Costio treialon addasol (CAT): datblygu canllawiau costio arfer gorau ar gyfer CTUs sy'n cefnogi treialon addasol (£55,629)
- NIHR HTA: Gwerthusiad procalcitonin a NEWS ar gyfer adnabod sepsis yn amserol a'r defnydd gorau posibl o wrthfiotigau yn yr adran achosion brys (PRONTO) (£1,968,786)
- NIHR PHR: Optimeiddio, profion dichonoldeb a threial peilot ar hap o SaFE: ymyrraeth iechyd rhywiol a pherthnasoedd iach ar gyfer addysg bellach (£510,815)
- EU H2020: Penderfyniad ar therapïau cyfunol gorau posibl mewn IMIDs gan ddefnyddio dulliau systemau (DocTIS) (€ 6,260,050)
2018
- Ymchwil JPND yr UE: Targedau ffordd o fyw aml-barth ar gyfer gwella prognosis mewn clefyd Huntington (DOMINO-HD) (€ 2,057,969)
- Cyllid Cymorth NIHR CTU: Pecyn cymorth ymarferol addasol a dylunio newydd (PANDA) (£98,886)
- HCRW RfPPB: Trin gorbryder i atal ailwaethygu mewn sgitsoffrenia (TAPERS) – treial dichonoldeb (£229,865)
Bywgraffiad
Addysg a chymwysterau
- 2016: PhD Bioystadegau, Leibniz Universität Hannover
- 2012: MSc Biotechnoleg Planhigion, Leibniz Universität Hannover
- 2010: BSc Biotechnoleg Planhigion, Leibniz Universität Hannover
Anrhydeddau a dyfarniadau
- 2023: Gwobr adolygydd cymheiriaid y flwyddyn am y Journal of Clinical Epidemiology
- 2013: Gwobr Bernd Streitberg o'r Gymdeithas Biometreg Ryngwladol (Rhanbarth yr Almaen) am fy nhraethawd hir MSc Profion dau sampl a phrofion cyferbyniad lluosog o sawl mynegai amrywiaeth
-
2012: Ail Wobr am y Cyflwyniad Llafar Myfyrwyr Gorau yn y 36ain Cynhadledd Biometrig Ryngwladol yn Kobe, Japan
Aelodaethau proffesiynol
- Cyd-arweinydd Gweithgor Dylunio Addasol Partneriaeth Ymchwil Methodoleg Treialon MRC-NIHR
- Aelod o Weithgor Therapïau Uwch Rhwydwaith Huntington Ewropeaidd a Thasglu Dylunio Treialon Clinigol Therapïau Uwch
Safleoedd academaidd blaenorol
- 2026 - presennol: Dirprwy Gyfarwyddwr (Treialon Heintiau, Llid ac Imiwnedd), Canolfan Ymchwil Treialon, Prifysgol Caerdydd
- 2024 - presennol: Prif Gymrawd Ymchwil, Canolfan Ymchwil Treialon, Prifysgol Caerdydd
- 2022 - 2024: Uwch Gymrawd Ymchwil, Canolfan Ymchwil Treialon, Prifysgol Caerdydd
- 2017 - 2023: Dirprwy Gyfarwyddwr (Gwasanaeth Dylunio a Chynnal Ymchwil De-ddwyrain Cymru), Canolfan Ymchwil Treialon, Prifysgol Caerdydd
- 2017 - 2022: Cymrawd Ymchwil, Canolfan Ymchwil Treialon, Prifysgol Caerdydd
- 2015 - 2017: Uwch Gydymaith Ymchwil, Adran Mathemateg ac Ystadegau, Prifysgol Caerhirfryn
- 2012 - 2015: Cydymaith Ymchwil , Sefydliad Bioystadegau, Leibniz Universität Hannover
- 2010 - 2012: Cynorthwy-ydd Ymchwil, Sefydliad Bioystadegau, Leibniz Universität Hannover
- 2009 - 2010: Cynorthwyydd Addysgu, Sefydliad Clefydau Planhigion a Diogelu Planhigion, Leibniz Universität Hannover
Ymrwymiadau siarad cyhoeddus
Cyflwyniadau Cynhadledd (dewisol)
- Heriau dylunio a chyflwyno treial ar hap clystyrau stepped-lletem o bwndel ymyrraeth cymhleth mewn gofal mamolaeth gan ddefnyddio data gofal iechyd a gesglir fel mater o drefn. 9fed cyfarfod blynyddol ar ddatblygiadau cyfredol mewn treialon ar hap clwstwr a dyluniadau lletem cam, Llundain, y DU. 9 Tachwedd 2023. Cyd-awduron: Sarah Kotecha, Julia Townson, Dimitrios Profer, Amy Elsmore, William Parry-Smith, Peter Collins, Sarah Bell.
- Mae treial yn dylunio gyda rhagoriaeth gyd-gynradd a diweddbwyntiau nad ydynt yn israddol: pwyntiau trafod methodolegol a chanllawiau ymarferol. Cynhadledd Methodoleg Treialon Clinigol Rhyngwladol 6ed, Harrogate, y DU. 5 Hydref 2022. Cyd-awduron: Simon Schoenbuchner, Abin Thomas, David Gillespie.
- Rhanbarthau hyder ar yr un pryd ar gyfer bioequivalence aml-baramedr. 62ain Biometrisches Kolloquium & DAGStat, Göttingen, Yr Almaen. 18 Mawrth 2016. Cyfarwyddwr: Thomas Jaki
- Profion cyferbyniad lluosog gyda data hydredol. Cynhadledd Ryngwladol ar Gasgliad ar y pryd, Hannover, yr Almaen. 25 Medi 2013.
- Sefydlu bioequivalence mewn treialon traws-dros-dro AB/BA gan ddefnyddio'r gymhareb o AUCs a amcangyfrifir o ddyluniadau samplu bras. 59fed Biometrisches Kolloquium & DAGStat, Freiburg, Yr Almaen. 19 Mawrth 2013. Llenyddiaeth: Thomas Jaki, Martin J Wolfsegger
- Cymharu bioamrywiaeth drwy brofi detholiad o fynegeion amrywiaeth a ddiffiniwyd gan y defnyddiwr ar yr un pryd. 36ain Cynhadledd Biometrig Ryngwladol, Kobe, Japan. 30 Awst 2012.
- Cymharu bioamrywiaeth drwy brofi detholiad o fynegeion amrywiaeth a ddiffiniwyd gan y defnyddiwr ar yr un pryd. 58fed Biometrisches Kolloquium, Berlin, yr Almaen. 14 Mawrth 2012.
Posteri cynhadledd (dewiswyd)
- Ehangiad dos effeithlon sy'n seiliedig ar fodel ar flaenau eich bysedd: offeryn meddalwedd syml i ddylunio a gwerthuso treialon canser cam I. Cynhadledd Canser NCRI, Lerpwl, y DU. 6 Tachwedd 2017. Cyd-awduron: Fang Wan, Christina Yap, Adrian P Mander, Graham M Wheeler, Sally Clive, Thomas Jaki, Lisa V Hampson.
- Dylunio treialon aml-gam aml-fraich gyda'r pecyn R 'MAMS'. Cynhadledd PSI, Berlin, yr Almaen. 23 Mai 2016. Cyd-awduron: Thomas Jaki, Dominic Magirr.
- Dadansoddiad o ddulliau gyda'r pecyn R 'ANOM'. 62ain Biometrisches Kolloquium & DAGStat, Göttingen, Yr Almaen. 16 Mawrth 2016. Cyd-awdur: Ludwig A Hothorn.
- Casgliad sampl fach ar yr un pryd mewn lleoliadau hydredol gan ddefnyddio cyferbyniadau lluosog. 60fed Biometrisches Kolloquium, Bremen, yr Almaen. 12 Mawrth 2014.
Pwyllgorau ac adolygu
Pwyllgorau goruchwylio allanol
- Aelod o'r Pwyllgor Llywio Treialon Annibynnol: NOTACS, TIP2, INTERACT, TREADON, FAITH, AD-SMART (ar hyn o bryd); MODULATE, TIP, PLAN-A, AML18/19 / LI1 (blaenorol)
- Aelod o'r Pwyllgor Monitro Data Annibynnol/Bwrdd Monitro Diogelwch Data: TRAITS, TRICEPS, ECRAID-Prime, SABRE, DETECT (ar hyn o bryd); ABC Sepsis, CANTOP-RCT (blaenorol)
Pwyllgorau cyllido
- Aelod o'r pwyllgor cyllido ar gyfer Gwobrau Ôl-ddoethurol MRC-NIHR EME/HTA (ers 2026)
- Aelod o'r pwyllgor cyllido ar gyfer Gwobrau Ôl-ddoethurol MRC-NIHR EME (2025-26)
- Aelod o'r pwyllgor cyllido ar gyfer Consortiwm Ymchwil Tiwmor yr Ymennydd NIHR (2025)
- Aelod o'r pwyllgor cyllido ar gyfer Cymrodoriaethau Uwch MRC-NIHR EME (2024-25)
- Aelod o'r pwyllgor cyllido ar gyfer MRC-NIHR EME (ers 2022)
- Aelod o Gyfadran Arbenigwyr ar gyfer galwad UKRI MRC AGHRB "Astudiaethau gweithredu brechlyn Malaria yn Affrica" (2024)
- Aelod o'r pwyllgor cyllido cyswllt ar gyfer NIHR HTA (2021-22)
Dyletswyddau golygyddol
- Golygydd Cyswllt ar gyfer Treialon
- Cynghorydd Ystadegol ar gyfer Iechyd Plant a'r Glasoed The Lancet
Adolygu
- Adolygydd cais grant ar gyfer NIHR (HTA, PHR, HS&DR), MRC (BMC DPFS, Better Methods Better Research), MRC-NIHR (EME, Rhaglen Ymchwil Methodoleg), HRB TMRN/MRC-NIHR TMRP (Cyd-ariannu Prosiect Gweithgor), UKRI (Cymrodoriaeth Arweinwyr y Dyfodol), HCRW (Ysgoloriaeth Iechyd PhD, Llwybr i Bortffolio), Blood Cancer UK yn ogystal ag yn rhyngwladol (HRB - Bwrdd Ymchwil Iechyd Iwerddon; DFG - Sefydliad Gwyddoniaeth yr Almaen; NCN - Canolfan Wyddoniaeth Genedlaethol Gwlad Pwyl; ZonMW - Sefydliad yr Iseldiroedd ar gyfer Ymchwil a Datblygu Iechyd; Inserm - Sefydliad Cenedlaethol Iechyd ac Ymchwil Feddygol Ffrainc; Canolfan Ymchwil Feddygol yng Nghorfforaeth Feddygol Hamad, Qatar)
- Adolygydd adroddiad terfynol ar gyfer NIHR (HTA, PHR)
- Adolygydd crynodeb cynhadledd ar gyfer 38ain Cyfarfod Blynyddol ESPID 2020, ICTMC 2022, ICTMC 2024, ICTMC 2026, SAPC ASM 2025
- Adolygydd cynigion llyfrau ar gyfer Gwasg Prifysgol Caergrawnt
- Adolygydd llawysgrif ar gyfer cyfnodolion gan gynnwys Statistics in Medicine, Biometrical Journal, The American Statistician, Journal of the American Statistical Association, Statistical Methods in Medical Research, Statistical Papers, Statistics, Stat, Journal of Applied Statistics, Journal of Biopharmaceutical Statistics, Communications in Statistics - Simulation and Computation, Journal of Statistical Computation and Simulation, Journal of Computational and Graphical Statistics, Statistica Neerlandica, Journal of Clinical Epidemiology, Journal of Statistical Software, Journal of Open Source Software, SoftwareX, Computer Methods and Programs in Biomedicine, Applied Stochastic Models in Business and Industry, BMJ Open, PLOS One, Royal Society Open Science, Scientific Reports, PeerJ, Trials, Clinical Trials, Contemporary Clinical Trials, BMC Medical Research Methodology, Implementation Science, Journal of the National Cancer Institute, British Journal of Cancer, Journal of Infection, Journal of Hospital Infection, Journal of the American Society of Nephrology, Frontiers in Neurology, BMJ Nutrition Prevention & Health, Trallwyso, Journal of Clinical Medicine, BMJ Medicine, The Lancet Child & Adolescent Health, The Lancet Regional Health Southeast Asia, eClinicalMedicine, eBioMedicine, Adolygiad Arbenigol o Therapi Gwrth-Heintus, Microbioleg Diagnostig a Chlefyd Heintus, Nature Communications, Nature Reviews Drug Discovery, Nature Human Behaviour, The AAPS Journal, The British Student Doctor Journal, Future Internet, Environmental Science & Pollution Research, Pest Management Science (gweler hefyd fy mhroffil Publons)
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Malavika Babu
Nathan Riddell
Tamas Barry
Prosiectau'r gorffennol
- Cyd-oruchwyliwr ar gyfer Joseph Caldwell (Prifysgol Caerhirfryn) - Amcangyfrif diduedd a llai o ragfarn mewn treialon addasol gyda phwyntiau terfynol cyd-gynradd cydberthynas a heb gydberthynas yng nghyd-destun treial clinigol PRONTO (Ystadegau MSc, 2024, gyda Fang Wan)
- Cyd-oruchwyliwr ar gyfer Andreas Markoulidakis - Dulliau ystadegol ar gyfer adnabod a modelu ffactorau ffordd o fyw sy'n gysylltiedig â difrifoldeb a dilyniant clefyd Huntington (PhD, 2024, gyda Peter Holmans, Monica Busse, a Beth Ann Griffin)
- Goruchwyliwr arweiniol ar gyfer Kittinan Praesertrungrueang – Datblygu a phrofi offeryn rhagfynegi newydd ar gyfer canlyniadau clinigol ar ôl amputation aelodau isaf mawr (MSc Data Science and Analytics, 2023, gyda David Bosanquet a Brenig Gwilym)
- Cyd-oruchwyliwr ar gyfer William Blake – Cymhwyso technegau casglu achosol i amcangyfrif effaith newidynnau ffordd o fyw ar ddifrifoldeb clefyd Huntington (MSc Ymchwil Weithredol ac Ystadegau Cymhwysol, 2022, gydag Andreas Markoulidakis a Monica Busse)
- Cyd-oruchwyliwr ar gyfer Saif Abbas Chatoo – Rhagnodi gwrthfiotigau mewn cleifion sydd yn yr ysbyty â COVID-19 fel swyddogaeth marcwyr llidiol mewn ton 1 yn erbyn ton 2: adolygiad systematig (Intercalated BSc Population Medicine, 2022, gyda Joanne Euden ac Emma Thomas-Jones)
Goruchwyliaeth gyfredol (allanol)
- Cyd-oruchwyliwr ar gyfer Joseph Caldwell (Prifysgol Caerhirfryn) – Dyluniadau treialon platfform addasol ar gyfer ymchwil stiwardiaeth gwrthficrobaidd (Cymrodoriaeth Cyn-ddoethurol NIHR, gyda Fang Wan)
Arholiad PhD
- Arholwr allanol ar gyfer Aritra Mukherjee (Prifysgol Newcastle, y DU) ac Erin Nolan (Prifysgol Newcastle, Awstralia)
- Arholwr mewnol ar gyfer Genevieve Meier (Prifysgol Caerdydd)
Contact Details
[email protected]
+44 29206 87461
Neuadd Meirionnydd, Ystafell 505, 5ed llawr, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
+44 29206 87461
Neuadd Meirionnydd, Ystafell 505, 5ed llawr, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
Arbenigeddau
- Ystadegau
- Ystadegau cymhwysol
- Ymchwil clinigol cymhwysol
- Gofal sy'n seiliedig ar dystiolaeth