![Philip Pallmann](https://profiles-cardiff.imgix.net/attachments/3624?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Philip Pallmann
Uwch Gymrawd Ymchwil
- PallmannP@caerdydd.ac.uk
- +44 29206 87461
- Neuadd Meirionnydd, Ystafell 505, 5ed llawr, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Rwy'n Uwch Gymrawd Ymchwil yn y Ganolfan Ymchwil Treialon lle rwy'n gweithio fel ystadegydd meddygol ar ddylunio, ymddygiad, dadansoddi ac adrodd ar hapdreialon rheoledig ac astudiaethau eraill a gynlluniwyd yn dda.
Mae fy nghefndir mewn ystadegau cymhwysol, ond rwy'n gweithio ar draws ystod eang o feysydd clinigol gan gynnwys heintiau, clefydau niwroddirywiol ac iechyd y boblogaeth, yn ogystal ag ar hyrwyddo methodoleg treialon clinigol, yn enwedig dulliau dylunio effeithlon fel dyluniadau addasol.
Rwy'n cyd-arwain Gweithgor Dyluniadau Addasol Partneriaeth Ymchwil Methodoleg Treialon MRC-NIHR, ynghyd â Sofía Villar.
Rwy'n aelod o bwyllgor cyllido MRC-NIHR Effeithiolrwydd a Gwerthuso Mecanwaith (EME).
Rwy'n Olygydd Cyswllt ar gyfer y cyfnodolyn a adolygir gan gymheiriaid Trials.
Cyhoeddiad
2023
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse, M., Godley, M. D. and Griffin, B. A. 2023. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology 23, pp. 115-148. (10.1007/s10742-022-00280-0)
- Schoenbuchner, S. M., Huang, C., Waldron, C., Thomas-Jones, E., Hood, K., Carrol, E. D. and Pallmann, P. 2023. Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials 24(1), article number: 364. (10.1186/s13063-022-06956-9)
- Robertson, D. S., Choodari-Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2023. Point estimation for adaptive trial designs II: practical considerations and guidance. Statistics in Medicine 42(8) (10.1002/sim.9734)
- Adara, L. et al. 2023. The Social Workers in Schools Trial: An evaluation of school based social work.. Project Report. Early Intervention Foundation.
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24, article number: 75. (10.1186/s13063-023-07090-w)
2022
- Lenihan, R. A. F. et al. 2022. Mid-regional pro-adrenomedullin in combination with pediatric early warning scores for risk stratification of febrile children presenting to the emergency department: secondary analysis of a nonprespecified United Kingdom cohort study. Pediatric Critical Care Medicine 23(12), pp. 980-989. (10.1097/PCC.0000000000003075)
- Gwilym, B. L. et al. 2022. Short-term risk prediction after major lower limb amputation: PERCEIVE study. BJS Open 109(12), pp. 1300-1311. (10.1093/bjs/znac309)
- Llewelyn, M. J., West, R. M., Carrol, E. D., Pallmann, P. and Sandoe, J. A. T. 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data - authors' response. Journal of Antimicrobial Chemotherapy 77(11), pp. 3211-3212., article number: dkac315. (10.1093/jac/dkac315)
- Kumwenda, M. et al. 2022. Identifying critically ill children at risk of dying during hospital admission in Malawi: prognostic accuracy of a modified qSOFA score for low-resource settings. Presented at: 11th World Congress on Pediatric Intensive and Critical Care, Virtual, 12-16 July 2022, Vol. 23. Vol. OP044., (10.1097/01.pcc.0000899856.14238.94)
- Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2022. Point estimation for adaptive trial designs I: A methodological review. Statistics in Medicine (10.1002/sim.9605)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH): protocol for a retrospective observational study. Methods and Protocols 5(6), article number: 95. (10.3390/mps5060095)
- Metzler-Baddeley, C., Busse, M. E., Drew, C. J., Pallmann, P., Jones, D. K. and Rosser, A. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September 2022, Vol. 93. Vol. S1. pp. A100-A101., (10.1136/jnnp-2022-ehdn.267)
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93(S1), article number: A44. (10.1136/jnnp-2022-ehdn.114)
- Markoulidakis, A., Busse, M., Doheny, E., Drew, C., Kirby, N. and Pallmann, P. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September, Vol. 93. Vol. S1., (10.1136/jnnp-2022-ehdn.111)
- Love, S. B. et al. 2022. Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units. Trials 23, article number: 757. (10.1186/s13063-022-06680-4)
- Westlake, D. et al. 2022. Evaluating a school-based intervention through routine local authority data and national school data: challenges and opportunities. Presented at: International Population Data Linkage Conference 2022, 7 - 9 September 2022, Vol. 7. Vol. 3., (10.23889/ijpds.v7i3.1886)
- Wason, J. M. S. et al. 2022. Practical guidance for planning resources required to support publicly‑funded adaptive clinical trials. BMC Medicine 20, article number: 254. (10.1186/s12916-022-02445-7)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6(6), article number: e36870. (10.2196/36870)
- Chatoo, S. A., Thomas-Jones, E., Pallmann, P. and Euden, J. 2022. Antibiotic prescribing in hospitalized patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review. Presented at: BSAC Spring Conference 2022, 10 - 11 May 2022, Vol. 4. Vol. S.2., (10.1093/jacamr/dlac053.012)
- Euden, J. et al. 2022. PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open 12(6), article number: e063424. (10.1136/bmjopen-2022-063424)
- Westlake, D. et al. 2022. The SWIS trial: protocol of a pragmatic cluster randomised controlled trial of school based social work. PLoS ONE 17(6), article number: e0265354. (10.1371/journal.pone.0265354)
- Llewelyn, M. J. et al. 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data. Journal of Antimicrobial Chemotherapy 77(4), pp. 1189-1196. (10.1093/jac/dkac017)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study. Presented at: Infection 2021: BSAC Winter Conference, Virtual, 9-10 December 2021, Vol. 4. Vol. 1., (10.1093/jacamr/dlac004.013)
- Waldron, C. et al. 2022. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial. BMJ Open 12(1), article number: e047490. (10.1136/bmjopen-2020-047490)
- Milosevic, S. et al. 2022. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation: a collaboratiVE study (PERCEIVE)—protocol for the PERCEIVE qualitative study. BMJ Open 12(1), article number: e053159. (10.1136/bmjopen-2021-053159)
- Powell, E., James, D., Collis, R., Collins, P., Pallmann, P. and Bell, S. 2022. Introduction of standardized, cumulative quantitative measurement of blood loss into routine maternity care. Journal of Maternal-Fetal and Neonatal Medicine 35(8), pp. 1491-1497. (10.1080/14767058.2020.1759534)
- Dimairo, M. et al. 2022. PANDA: a practical adaptive and novel designs and analysis toolkit. [Online]. University of Sheffield. Available at: https://panda.shef.ac.uk/
2021
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. CoBWeb: a user-friendly web application to estimate causal treatment effects from observational data using multiple algorithms. [Online]. Cornell University. Available at: https://arxiv.org/abs/2112.05035
- Gwilym, B. L. et al. 2021. The PERCEIVE quantitative study: PrEdiction of Risk and Communication of outcome following major lower-limb amputation: protocol for a collaboratiVE study. BJS Open 5(6), article number: zrab118. (10.1093/bjsopen/zrab118)
- Richards, O. et al. 2021. Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS. Antibiotics 10(11), article number: 1425. (10.3390/antibiotics10111425)
- Wilson, N. et al. 2021. Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine 19, article number: 251. (10.1186/s12916-021-02124-z)
- Preece, R. et al. 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62(1), pp. 127-135. (10.1016/j.ejvs.2021.02.038)
- Romaine, S. T. et al. 2021. Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study. BMJ Open 11(5), article number: e044091. (10.1136/bmjopen-2020-044091)
- Robertson, D. S., Choodari-Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2021. Point estimation for adaptive trial designs. [Online]. Cornell University. Available at: https://arxiv.org/abs/2105.08836
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. BMC Pregnancy and Childbirth 21, article number: 377. (10.1186/s12884-021-03853-y)
- Powell, N. et al. 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10(5), article number: 516. (10.3390/antibiotics10050516)
- Gwilym, B. et al. 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study. Presented at: National Research Collaborative Meeting 2020 (NRCM 2020), Virtual, 19 November - 10 December 2020, Vol. 5. Vol. Supple. Wiley, (10.1093/bjsopen/zrab032.089)
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. SSRN: Available at: http://doi.org/10.2139/ssrn.3746928
- Wheeler, M., Powell, E. and Pallmann, P. 2021. Use of high-fidelity simulation training for radiology healthcare professionals in the management of acute medical emergencies. British Journal of Radiology 94(1117), article number: 20200520. (10.1259/bjr.20200520)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3(1), article number: fcaa230. (10.1093/braincomms/fcaa230)
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. How balance and sample size impact bias in the estimation of causal treatment effects: a simulation study. [Online]. Cornell University. Available at: https://arxiv.org/abs/2107.09009
2020
- Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. and Jaki, T. 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. BMC Medicine 18, article number: 352. (10.1186/s12916-020-01808-2)
- Romaine, S. T. et al. 2020. Accuracy of a modified qSOFA score for predicting critical care admission in febrile children. Pediatrics 146(4), article number: e20200782. (10.1542/peds.2020-0782)
- Dimairo, M. et al. 2020. The Adaptive designs CONSORT Extension (ACE) Statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ 369, article number: m115. (10.1136/bmj.m115)
- Dimairo, M. et al. 2020. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21, article number: 528. (10.1186/s13063-020-04334-x)
- Parkes, M., Lunt, M., Pallmann, P. and Felson, D. 2020. Futility of the treatment, rather than futility of the trial, as the primary focus of interim analyses in clinical trials. Presented at: Society for Clinical Trials (SCT) 40th Annual Meeting, New Orleans, LA, US, 19-22 May 2019, Vol. 17. Vol. 1_Supp. SAGE Publications (UK and US) pp. 62., (10.1177/1740774520907457)
- Pallmann, P. et al. 2020. Designing and evaluating dose-escalation studies made easy: the MoDEsT web app. Clinical Trials 17(2), pp. 147-156. (10.1177/1740774519890146)
- Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. and Jaki, T. 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. [Online]. arXiv. Available at: https://arxiv.org/abs/2006.12811
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse-Morris, M. and Griffin, B. A. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online]. arXiv. Available at: https://arxiv.org/abs/2010.09563
2019
- Dimairo, M. et al. 2019. Introducing the Adaptive designs CONSORT Extension (ACE) Statement to improve reporting of randomised trials that use an adaptive design (P-7). Presented at: 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK, 6-9 October 2019. BioMed Central pp. -., (10.1186/s13063-019-3688-6)
- Hornbacher, J., Rumlow, A., Pallmann, P., Turcios, A. E., Riemenschneider, A. and Papenbrock, J. 2019. The levels of sulfur-containing metabolites in Brassica napus are not influenced by the circadian clock but diurnally. Journal of Plant Biology 62(5), pp. 359-373. (10.1007/s12374-019-0143-x)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Jansen, J. O., Pallmann, P., MacLennan, G. and Campbell, M. K. 2019. Bayesian clinical trial designs another option for trauma trials? Erratum. Journal of Trauma and Acute Care Surgery 86(4), pp. 760. (10.1097/TA.0000000000002236)
- Jaki, T., Pallmann, P. and Magirr, D. 2019. The R package MAMS for designing multi-arm multi-stage clinical trials. Journal of Statistical Software 88(4)
2018
- Dimairo, M. et al. 2018. Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine 16(1), article number: 210. (10.1186/s12916-018-1196-2)
- Pallmann, P., Ritz, C. and Hothorn, L. A. 2018. Simultaneous small-sample comparisons in longitudinal or multi-endpoint trials using multiple marginal models. Statistics in Medicine 37(9), pp. 1562-1576. (10.1002/sim.7610)
- Pallmann, P. et al. 2018. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine 16, article number: 29. (10.1186/s12916-018-1017-7)
2017
- Pallmann, P. and Jaki, T. 2017. Simultaneous confidence regions for multivariate bioequivalence. Statistics in Medicine 36(29), pp. 4585-4603. (10.1002/sim.7446)
- Pallmann, P., Pretorius, M. and Ritz, C. 2017. Simultaneous comparisons of treatments at multiple time points: Combined marginal models versus joint modeling. Statistical Methods in Medical Research 26(6), pp. 2633-2648. (10.1177/0962280215603743)
- Jansen, J. O., Pallmann, P., MacLennan, G. and Campbell, M. K. 2017. Bayesian clinical trial designs: Another option for trauma trials?. Journal of Trauma and Acute Care Surgery 83(4), pp. 736-741. (10.1097/TA.0000000000001638)
- Parkes, M., Lunt, M., Pallmann, P. and Felson, D. T. 2017. The two-stage treatment selection (TSTS) design: a novel approach to treatment selection in clinical trials. Trials 18(S1), pp. 166., article number: P440. (10.1186/s13063-017-1902-y)
- Otieno, J. A., Pallmann, P. and Poehling, H. 2017. Additive and synergistic interactions amongst Orius laevigatus (Heteroptera: Anthocoridae), entomopathogens and azadirachtin for controlling western flower thrips (Thysanoptera: Thripidae). BioControl 62(1), pp. 85-95. (10.1007/s10526-016-9767-7)
- Pallmann, P. 2017. Sample size determination in clinical trials with multiple endpoints. T. Sozu, R. Sugimoto, T. Hamasaki, and S. R. Evans (2015). New York, NY: Springer. 95 pages, ISBN: 978-3-319-22004-8. Biometrical Journal 59(1), pp. 218. (10.1002/bimj.201600135)
2016
- Rumlow, A., Keunen, E., Klein, J., Pallmann, P., Riemenschneider, A., Cuypers, A. and Papenbrock, J. 2016. Quantitative expression analysis in brassica napus by northern blot analysis and reverse transcription-quantitative PCR in a complex experimental setting. PLoS ONE 11(9), article number: e0163679. (10.1371/journal.pone.0163679)
- Pallmann, P. and Hothorn, L. A. 2016. Boxplots for grouped and clustered data in toxicology. Archives of Toxicology 90(7), pp. 1631-1638. (10.1007/s00204-015-1608-4)
- Otieno, J. A., Pallmann, P. and Poehling, H. -. 2016. The combined effect of soil-applied azadirachtin with entomopathogens for integrated management of western flower thrips. Journal of Applied Entomology 140(3), pp. 174-186. (10.1111/jen.12242)
- Pallmann, P. and Hothorn, L. A. 2016. Analysis of means: a generalized approach using R. Journal of Applied Statistics 43(8), pp. 1541-1560. (10.1080/02664763.2015.1117584)
- Pallmann, P. and Schaarschmidt, F. 2016. Common pitfalls when testing additivity of treatment mixtures with chi-square analyses. Journal of Applied Entomology 140(1-2), pp. 135-141. (10.1111/jen.12258)
2015
- Pallmann, P. 2015. Simultaneous Statistical Inference: With Applications in the Life Sciences. T.Dickhaus (2014). Heidelberg: Springer. 180 pages, ISBN: 978-3-642-45181-2.. Biometrical Journal 57(6), pp. 1151-1152. (10.1002/bimj.201500129)
- Pallmann, P. 2015. Analyzing baseball data with R [book review]. Journal of the Royal Statistical Society Series A (Statistics in Society) 178(4), pp. 1099-1099. (10.1111/rssa.3_12138)
- Karanja, J., Poehling, H. and Pallmann, P. 2015. Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter, in the control of whiteflies, aleyrodes proletella and trialeurodes vaporariorum (hemiptera: aleyrodidae). Journal of Economic Entomology 108(3), pp. 1182-1190. (10.1093/jee/tov047)
- Weese, A., Pallmann, P., Papenbrock, J. and Riemenschneider, A. 2015. Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack. Frontiers in Plant Science 6, article number: 9. (10.3389/fpls.2015.00009)
2014
- Pallmann, P., Hothorn, L. A. and Djira, G. D. 2014. A Levene-type test of homogeneity of several variances against ordered alternatives. Computational Statistics 29, pp. 1593-1608. (10.1007/s00180-014-0508-z)
- Pallmann, P. 2014. Applied meta-analysis with R. Journal of Applied Statistics 42(4), pp. 914-915. (10.1080/02664763.2014.989464)
2013
- Jaki, T., Pallmann, P. and Wolfsegger, M. J. 2013. Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs. Statistics in Medicine 32(30), pp. 5469-5483. (10.1002/sim.5886)
- Jaki, T., Pallmann, P. and Wolfsegger, M. J. 2013. Authors' reply to Comments on 'Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs'. Statistics in Medicine 32(30), pp. 5487-5488. (10.1002/sim.6000)
2012
- Pallmann, P., Schaarschmidt, F., Hothorn, L. A., Fischer, C., Nacke, H., Priesnitz, K. U. and Schork, N. J. 2012. Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices. Molecular Ecology Resources 12(6), pp. 1068-1078. (10.1111/1755-0998.12004)
Articles
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse, M., Godley, M. D. and Griffin, B. A. 2023. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology 23, pp. 115-148. (10.1007/s10742-022-00280-0)
- Schoenbuchner, S. M., Huang, C., Waldron, C., Thomas-Jones, E., Hood, K., Carrol, E. D. and Pallmann, P. 2023. Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials 24(1), article number: 364. (10.1186/s13063-022-06956-9)
- Robertson, D. S., Choodari-Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2023. Point estimation for adaptive trial designs II: practical considerations and guidance. Statistics in Medicine 42(8) (10.1002/sim.9734)
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24, article number: 75. (10.1186/s13063-023-07090-w)
- Lenihan, R. A. F. et al. 2022. Mid-regional pro-adrenomedullin in combination with pediatric early warning scores for risk stratification of febrile children presenting to the emergency department: secondary analysis of a nonprespecified United Kingdom cohort study. Pediatric Critical Care Medicine 23(12), pp. 980-989. (10.1097/PCC.0000000000003075)
- Gwilym, B. L. et al. 2022. Short-term risk prediction after major lower limb amputation: PERCEIVE study. BJS Open 109(12), pp. 1300-1311. (10.1093/bjs/znac309)
- Llewelyn, M. J., West, R. M., Carrol, E. D., Pallmann, P. and Sandoe, J. A. T. 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data - authors' response. Journal of Antimicrobial Chemotherapy 77(11), pp. 3211-3212., article number: dkac315. (10.1093/jac/dkac315)
- Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2022. Point estimation for adaptive trial designs I: A methodological review. Statistics in Medicine (10.1002/sim.9605)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH): protocol for a retrospective observational study. Methods and Protocols 5(6), article number: 95. (10.3390/mps5060095)
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93(S1), article number: A44. (10.1136/jnnp-2022-ehdn.114)
- Love, S. B. et al. 2022. Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units. Trials 23, article number: 757. (10.1186/s13063-022-06680-4)
- Wason, J. M. S. et al. 2022. Practical guidance for planning resources required to support publicly‑funded adaptive clinical trials. BMC Medicine 20, article number: 254. (10.1186/s12916-022-02445-7)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6(6), article number: e36870. (10.2196/36870)
- Euden, J. et al. 2022. PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open 12(6), article number: e063424. (10.1136/bmjopen-2022-063424)
- Westlake, D. et al. 2022. The SWIS trial: protocol of a pragmatic cluster randomised controlled trial of school based social work. PLoS ONE 17(6), article number: e0265354. (10.1371/journal.pone.0265354)
- Llewelyn, M. J. et al. 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data. Journal of Antimicrobial Chemotherapy 77(4), pp. 1189-1196. (10.1093/jac/dkac017)
- Waldron, C. et al. 2022. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial. BMJ Open 12(1), article number: e047490. (10.1136/bmjopen-2020-047490)
- Milosevic, S. et al. 2022. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation: a collaboratiVE study (PERCEIVE)—protocol for the PERCEIVE qualitative study. BMJ Open 12(1), article number: e053159. (10.1136/bmjopen-2021-053159)
- Powell, E., James, D., Collis, R., Collins, P., Pallmann, P. and Bell, S. 2022. Introduction of standardized, cumulative quantitative measurement of blood loss into routine maternity care. Journal of Maternal-Fetal and Neonatal Medicine 35(8), pp. 1491-1497. (10.1080/14767058.2020.1759534)
- Gwilym, B. L. et al. 2021. The PERCEIVE quantitative study: PrEdiction of Risk and Communication of outcome following major lower-limb amputation: protocol for a collaboratiVE study. BJS Open 5(6), article number: zrab118. (10.1093/bjsopen/zrab118)
- Richards, O. et al. 2021. Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS. Antibiotics 10(11), article number: 1425. (10.3390/antibiotics10111425)
- Wilson, N. et al. 2021. Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine 19, article number: 251. (10.1186/s12916-021-02124-z)
- Preece, R. et al. 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62(1), pp. 127-135. (10.1016/j.ejvs.2021.02.038)
- Romaine, S. T. et al. 2021. Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study. BMJ Open 11(5), article number: e044091. (10.1136/bmjopen-2020-044091)
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. BMC Pregnancy and Childbirth 21, article number: 377. (10.1186/s12884-021-03853-y)
- Powell, N. et al. 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10(5), article number: 516. (10.3390/antibiotics10050516)
- Wheeler, M., Powell, E. and Pallmann, P. 2021. Use of high-fidelity simulation training for radiology healthcare professionals in the management of acute medical emergencies. British Journal of Radiology 94(1117), article number: 20200520. (10.1259/bjr.20200520)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3(1), article number: fcaa230. (10.1093/braincomms/fcaa230)
- Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. and Jaki, T. 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. BMC Medicine 18, article number: 352. (10.1186/s12916-020-01808-2)
- Romaine, S. T. et al. 2020. Accuracy of a modified qSOFA score for predicting critical care admission in febrile children. Pediatrics 146(4), article number: e20200782. (10.1542/peds.2020-0782)
- Dimairo, M. et al. 2020. The Adaptive designs CONSORT Extension (ACE) Statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ 369, article number: m115. (10.1136/bmj.m115)
- Dimairo, M. et al. 2020. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21, article number: 528. (10.1186/s13063-020-04334-x)
- Pallmann, P. et al. 2020. Designing and evaluating dose-escalation studies made easy: the MoDEsT web app. Clinical Trials 17(2), pp. 147-156. (10.1177/1740774519890146)
- Hornbacher, J., Rumlow, A., Pallmann, P., Turcios, A. E., Riemenschneider, A. and Papenbrock, J. 2019. The levels of sulfur-containing metabolites in Brassica napus are not influenced by the circadian clock but diurnally. Journal of Plant Biology 62(5), pp. 359-373. (10.1007/s12374-019-0143-x)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Jansen, J. O., Pallmann, P., MacLennan, G. and Campbell, M. K. 2019. Bayesian clinical trial designs another option for trauma trials? Erratum. Journal of Trauma and Acute Care Surgery 86(4), pp. 760. (10.1097/TA.0000000000002236)
- Jaki, T., Pallmann, P. and Magirr, D. 2019. The R package MAMS for designing multi-arm multi-stage clinical trials. Journal of Statistical Software 88(4)
- Dimairo, M. et al. 2018. Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine 16(1), article number: 210. (10.1186/s12916-018-1196-2)
- Pallmann, P., Ritz, C. and Hothorn, L. A. 2018. Simultaneous small-sample comparisons in longitudinal or multi-endpoint trials using multiple marginal models. Statistics in Medicine 37(9), pp. 1562-1576. (10.1002/sim.7610)
- Pallmann, P. et al. 2018. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine 16, article number: 29. (10.1186/s12916-018-1017-7)
- Pallmann, P. and Jaki, T. 2017. Simultaneous confidence regions for multivariate bioequivalence. Statistics in Medicine 36(29), pp. 4585-4603. (10.1002/sim.7446)
- Pallmann, P., Pretorius, M. and Ritz, C. 2017. Simultaneous comparisons of treatments at multiple time points: Combined marginal models versus joint modeling. Statistical Methods in Medical Research 26(6), pp. 2633-2648. (10.1177/0962280215603743)
- Jansen, J. O., Pallmann, P., MacLennan, G. and Campbell, M. K. 2017. Bayesian clinical trial designs: Another option for trauma trials?. Journal of Trauma and Acute Care Surgery 83(4), pp. 736-741. (10.1097/TA.0000000000001638)
- Parkes, M., Lunt, M., Pallmann, P. and Felson, D. T. 2017. The two-stage treatment selection (TSTS) design: a novel approach to treatment selection in clinical trials. Trials 18(S1), pp. 166., article number: P440. (10.1186/s13063-017-1902-y)
- Otieno, J. A., Pallmann, P. and Poehling, H. 2017. Additive and synergistic interactions amongst Orius laevigatus (Heteroptera: Anthocoridae), entomopathogens and azadirachtin for controlling western flower thrips (Thysanoptera: Thripidae). BioControl 62(1), pp. 85-95. (10.1007/s10526-016-9767-7)
- Pallmann, P. 2017. Sample size determination in clinical trials with multiple endpoints. T. Sozu, R. Sugimoto, T. Hamasaki, and S. R. Evans (2015). New York, NY: Springer. 95 pages, ISBN: 978-3-319-22004-8. Biometrical Journal 59(1), pp. 218. (10.1002/bimj.201600135)
- Rumlow, A., Keunen, E., Klein, J., Pallmann, P., Riemenschneider, A., Cuypers, A. and Papenbrock, J. 2016. Quantitative expression analysis in brassica napus by northern blot analysis and reverse transcription-quantitative PCR in a complex experimental setting. PLoS ONE 11(9), article number: e0163679. (10.1371/journal.pone.0163679)
- Pallmann, P. and Hothorn, L. A. 2016. Boxplots for grouped and clustered data in toxicology. Archives of Toxicology 90(7), pp. 1631-1638. (10.1007/s00204-015-1608-4)
- Otieno, J. A., Pallmann, P. and Poehling, H. -. 2016. The combined effect of soil-applied azadirachtin with entomopathogens for integrated management of western flower thrips. Journal of Applied Entomology 140(3), pp. 174-186. (10.1111/jen.12242)
- Pallmann, P. and Hothorn, L. A. 2016. Analysis of means: a generalized approach using R. Journal of Applied Statistics 43(8), pp. 1541-1560. (10.1080/02664763.2015.1117584)
- Pallmann, P. and Schaarschmidt, F. 2016. Common pitfalls when testing additivity of treatment mixtures with chi-square analyses. Journal of Applied Entomology 140(1-2), pp. 135-141. (10.1111/jen.12258)
- Pallmann, P. 2015. Simultaneous Statistical Inference: With Applications in the Life Sciences. T.Dickhaus (2014). Heidelberg: Springer. 180 pages, ISBN: 978-3-642-45181-2.. Biometrical Journal 57(6), pp. 1151-1152. (10.1002/bimj.201500129)
- Pallmann, P. 2015. Analyzing baseball data with R [book review]. Journal of the Royal Statistical Society Series A (Statistics in Society) 178(4), pp. 1099-1099. (10.1111/rssa.3_12138)
- Karanja, J., Poehling, H. and Pallmann, P. 2015. Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter, in the control of whiteflies, aleyrodes proletella and trialeurodes vaporariorum (hemiptera: aleyrodidae). Journal of Economic Entomology 108(3), pp. 1182-1190. (10.1093/jee/tov047)
- Weese, A., Pallmann, P., Papenbrock, J. and Riemenschneider, A. 2015. Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack. Frontiers in Plant Science 6, article number: 9. (10.3389/fpls.2015.00009)
- Pallmann, P., Hothorn, L. A. and Djira, G. D. 2014. A Levene-type test of homogeneity of several variances against ordered alternatives. Computational Statistics 29, pp. 1593-1608. (10.1007/s00180-014-0508-z)
- Pallmann, P. 2014. Applied meta-analysis with R. Journal of Applied Statistics 42(4), pp. 914-915. (10.1080/02664763.2014.989464)
- Jaki, T., Pallmann, P. and Wolfsegger, M. J. 2013. Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs. Statistics in Medicine 32(30), pp. 5469-5483. (10.1002/sim.5886)
- Jaki, T., Pallmann, P. and Wolfsegger, M. J. 2013. Authors' reply to Comments on 'Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs'. Statistics in Medicine 32(30), pp. 5487-5488. (10.1002/sim.6000)
- Pallmann, P., Schaarschmidt, F., Hothorn, L. A., Fischer, C., Nacke, H., Priesnitz, K. U. and Schork, N. J. 2012. Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices. Molecular Ecology Resources 12(6), pp. 1068-1078. (10.1111/1755-0998.12004)
Conferences
- Kumwenda, M. et al. 2022. Identifying critically ill children at risk of dying during hospital admission in Malawi: prognostic accuracy of a modified qSOFA score for low-resource settings. Presented at: 11th World Congress on Pediatric Intensive and Critical Care, Virtual, 12-16 July 2022, Vol. 23. Vol. OP044., (10.1097/01.pcc.0000899856.14238.94)
- Metzler-Baddeley, C., Busse, M. E., Drew, C. J., Pallmann, P., Jones, D. K. and Rosser, A. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September 2022, Vol. 93. Vol. S1. pp. A100-A101., (10.1136/jnnp-2022-ehdn.267)
- Markoulidakis, A., Busse, M., Doheny, E., Drew, C., Kirby, N. and Pallmann, P. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September, Vol. 93. Vol. S1., (10.1136/jnnp-2022-ehdn.111)
- Westlake, D. et al. 2022. Evaluating a school-based intervention through routine local authority data and national school data: challenges and opportunities. Presented at: International Population Data Linkage Conference 2022, 7 - 9 September 2022, Vol. 7. Vol. 3., (10.23889/ijpds.v7i3.1886)
- Chatoo, S. A., Thomas-Jones, E., Pallmann, P. and Euden, J. 2022. Antibiotic prescribing in hospitalized patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review. Presented at: BSAC Spring Conference 2022, 10 - 11 May 2022, Vol. 4. Vol. S.2., (10.1093/jacamr/dlac053.012)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study. Presented at: Infection 2021: BSAC Winter Conference, Virtual, 9-10 December 2021, Vol. 4. Vol. 1., (10.1093/jacamr/dlac004.013)
- Gwilym, B. et al. 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study. Presented at: National Research Collaborative Meeting 2020 (NRCM 2020), Virtual, 19 November - 10 December 2020, Vol. 5. Vol. Supple. Wiley, (10.1093/bjsopen/zrab032.089)
- Parkes, M., Lunt, M., Pallmann, P. and Felson, D. 2020. Futility of the treatment, rather than futility of the trial, as the primary focus of interim analyses in clinical trials. Presented at: Society for Clinical Trials (SCT) 40th Annual Meeting, New Orleans, LA, US, 19-22 May 2019, Vol. 17. Vol. 1_Supp. SAGE Publications (UK and US) pp. 62., (10.1177/1740774520907457)
- Dimairo, M. et al. 2019. Introducing the Adaptive designs CONSORT Extension (ACE) Statement to improve reporting of randomised trials that use an adaptive design (P-7). Presented at: 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK, 6-9 October 2019. BioMed Central pp. -., (10.1186/s13063-019-3688-6)
Monographs
- Adara, L. et al. 2023. The Social Workers in Schools Trial: An evaluation of school based social work.. Project Report. Early Intervention Foundation.
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. SSRN: Available at: http://doi.org/10.2139/ssrn.3746928
Websites
- Dimairo, M. et al. 2022. PANDA: a practical adaptive and novel designs and analysis toolkit. [Online]. University of Sheffield. Available at: https://panda.shef.ac.uk/
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. CoBWeb: a user-friendly web application to estimate causal treatment effects from observational data using multiple algorithms. [Online]. Cornell University. Available at: https://arxiv.org/abs/2112.05035
- Robertson, D. S., Choodari-Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2021. Point estimation for adaptive trial designs. [Online]. Cornell University. Available at: https://arxiv.org/abs/2105.08836
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. How balance and sample size impact bias in the estimation of causal treatment effects: a simulation study. [Online]. Cornell University. Available at: https://arxiv.org/abs/2107.09009
- Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. and Jaki, T. 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. [Online]. arXiv. Available at: https://arxiv.org/abs/2006.12811
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse-Morris, M. and Griffin, B. A. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online]. arXiv. Available at: https://arxiv.org/abs/2010.09563
Ymchwil
Crynodeb o'm hymchwil
Ar hyn o bryd rwy'n gweithio ar nifer o dreialon (gan gynnwys BATCH, DocTIS®, LISTEN®, OBS UK, PLACEMENT®, PRECISE, PRONTO, SaFE, SWIS, TIPTOE®) ac astudiaethau arsylwadol (gan gynnwys DOMINO-HD, Family VOICE, PEACH a PERCEIVE). Fi yw'r prif ymchwilydd ar gyfer PROTECT. Mae astudiaethau blaenorol yr wyf wedi gweithio arnynt yn cynnwys FLAME®, TAPERS a TRIDENT®.
Rwyf wedi bod yn cymryd rhan weithredol ym Mhrosiect ACE i ddatblygu estyniad CONSORT swyddogol ar gyfer treialon clinigol gyda dyluniad addasol, Prosiect PANDA i greu platfform ar-lein addysgol am ddyluniadau addasol, a'r Prosiect CAT i ddatblygu arfer gorau sy'n costio canllawiau ar gyfer CTUs sy'n cefnogi treialon dylunio addasol.
Rwyf wedi ysgrifennu (cyd-) a / neu rwy'n cynnal nifer o becynnau R sydd ar gael yn rhwydd ar CRAN®, gan gynnwys MAMS (astudiaethau aml-gam aml-fraich), BayesMAMS (astudiaethau aml-gam aml-fraich Bayesaidd), jocre (rhanbarthau cyd-hyder), cymedrol (treialon cynyddu dosau sy'n seiliedig ar fodel), ANOM (dadansoddiad o ddulliau) a simboot (casgliad ar yr un pryd ar gyfer mynegeion amrywiaeth).
Rhwng 2017 a 2023 roeddwn yn Ddirprwy Gyfarwyddwr y Gwasanaeth Dylunio ac Ymddygiad Ymchwil (RDCS) ar gyfer De-ddwyrain Cymru, a fu'n gweithio gyda'r GIG a staff gofal cymdeithasol i ddatblygu ceisiadau ariannu o ansawdd uchel ar gyfer prosiectau ymchwil arloesol ym maes iechyd a gofal cymdeithasol.
Dyfarnwyd cyllid grant yn ddiweddar
2023
- NIHR HTA: Gwerthuso ar hap platfform o ganlyniadau clinigol gan ddefnyddio technolegau newydd i optimeiddio therapi gwrthficrobaidd (PROTECT) (£204,987)
2022
- NIHR HSDR: Clinigol a chost-effeithiolrwydd rhaglen gwella ansawdd mamolaeth i leihau gwaedu gormodol a'r angen am drallwysiad ar ôl genedigaeth: camodd astudiaeth gwaedu obstetrig y DU (OBS UK) dreial ar hap clwstwr lletem (£3,650,790)
- NIHR HTA: Hunanreolaeth aml-barth mewn pobl hŷn sydd ag osteoarthritis ac aml-afiachedd (TIPTOE) (£1,711,355)
- NIHR CTU Cymorth Cyllid: Eirioliadau cadarn ar gyfer dyluniadau addasol (ROBIN): datblygu arfer gorau ar gyfer dadansoddiadau interim o ansawdd uchel a chyflym mewn treialon cam II-IV (£71,238)
- NIHR HTA: cathetr anesthetig lleol perineural ar ôl torri aelodau isaf (PLACEMENT) (PLACEMENT®) (£1,635,918)
2021
- NIHR Long COVID galwad: Cymorth hunanreoli personol COVID hir – cyd-ddylunio a gwerthuso (LISTEN) (£1,055,520)
- NIHR & DR: Cynadledda grŵp teulu ar gyfer plant a theuluoedd: gwerthuso gweithredu, cyd-destun ac effeithiolrwydd (Llais y Teulu) (£1,194,736)
2020
- NIHR HTA: Procalcitonin: gwerthuso defnydd gwrthfiotig mewn cleifion ysbyty COVID-19 (PEACH) (£731,858)
- HCRW RfPPB: PERCEIVE: rhagfynegi risg a chyfathrebu canlyniad yn dilyn torri aelodau isaf mawr – astudiaeth gydweithredol (£229,225)
- DfE WWCSC: Gweithwyr cymdeithasol mewn ysgolion sy'n cynyddu (SWIS) (£385,597)
- NIHR EME: MR-pro-adrenomedullin (MR-proADM) a gwerthusiad ImmunoXpert o hyd anitbiotig dan arweiniad procalcitonin mewn plant sydd â haint ar gyfer haenu effeithiolrwydd (PRECISE) (£385,450)
2019
- Cyllid Seilwaith HCRW CTU: Y Ganolfan Treialon Ymchwil 2020-23 (£2,470,489)
- Cyllid Cymorth CTU NIHR: Costau treialon addasol (CAT): datblygu arfer gorau sy'n costio canllawiau ar gyfer CTUs sy'n cefnogi treialon addasol (£55,629)
- NIHR HTA: Gwerthusiad Procalcitonin a NEWYDDION ar gyfer adnabod sepsis yn amserol a'r defnydd gorau posibl o wrthfiotigau yn yr adran frys (PRONTO) (£1,968,786)
- NIHR: Optimeiddio, profi dichonoldeb a threial peilot ar hap o SaFE: ymyrraeth iechyd rhywiol a pherthnasoedd iach ar gyfer addysg bellach (£510,815)
- H2020 yr UE: Penderfyniad ar therapïau cyfunol gorau posibl mewn IMIDs gan ddefnyddio dulliau systemau (DocTIS) (€ 6,260,050)
2018
- Ymchwil JPND yr UE: Targedau ffordd o fyw aml-barth ar gyfer gwella prognosis yng nghlwy'r Huntington (DOMINO-HD) (€ 2,057,969)
- Cyllid Cymorth CTU NIHR: Pecyn cymorth dylunio addasol a newydd ymarferol (PANDA) (£98,886)
- HCRW RfPPB: Trin pryder er mwyn atal llithro mewn sgitsoffrenia (TAPERS) – treial dichonoldeb (£229,865)
Bywgraffiad
Addysg a chymwysterau
- 2016: PhD Bioystadegau, Leibniz Universität Hannover
- 2012: MSc Biotechnoleg Planhigion, Leibniz Universität Hannover
- 2010: BSc Biotechnoleg Planhigion, Leibniz Universität Hannover
Anrhydeddau a dyfarniadau
- 2013: Gwobr Bernd Streitberg y Gymdeithas Biometrig Ryngwladol (Rhanbarth yr Almaen) am fy nhraethawd hir MSc Profion dau sampl a phrofion cyferbyniad lluosog o sawl mynegai amrywiaeth
2012: Ail Wobr am y Cyflwyniad Llafar Myfyrwyr Gorau yn y 36ain Cynhadledd Biometrig Ryngwladol yn Kobe, Japan
Aelodaethau proffesiynol
- Cyd-arweinydd y Gweithgor Dyluniadau Addasol, Partneriaeth Ymchwil Methodoleg Treialon MRC-NIHR (yn flaenorol: MRC Network of Hubs for Trials Methodology Research)
- Aelod o Rwydwaith Clefyd Huntington Ewrop
Safleoedd academaidd blaenorol
- 2022 - presennol: Uwch Gymrawd Ymchwil, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- 2017 - 2023: Dirprwy Gyfarwyddwr RDCS, Canolfan Ymchwil Treialon Prifysgol Caerdydd
- 2017 - 2022: Cymrawd Ymchwil, Canolfan Treialon Ymchwil, Prifysgol Caerdydd
- 2015 - 2017: Uwch Gydymaith Ymchwil, Adran Mathemateg ac Ystadegau, Prifysgol Lancaster
- 2012 - 2015: Cydymaith Ymchwil , Sefydliad Bioystadegau, Leibniz Universität Hannover
- 2010 - 2012: Cynorthwy-ydd Ymchwil, Sefydliad Bioystadegau, Leibniz Universität Hannover
- 2009 - 2010: Cynorthwy-ydd Addysgu, Sefydliad Clefydau Planhigion a Diogelu Planhigion, Leibniz Universität Hannover
Ymrwymiadau siarad cyhoeddus
Cyflwyniadau Cynhadledd (dewisol)
- Mae treial yn dylunio gyda rhagoriaeth gyd-gynradd a diweddbwyntiau nad ydynt yn israddol: pwyntiau trafod methodolegol a chanllawiau ymarferol. ICTMC, Harrogate, UK. 5 Hydref 2022. Cyd-awduron: Simon Schoenbuchner, Abin Thomas, David Gillespie.
- Rhanbarthau hyder ar yr un pryd ar gyfer bioequivalence aml-baramedr. 62ain Biometrisches Kolloquium & DAGStat, Göttingen, Yr Almaen. 18 Mawrth 2016. Cyfarwyddwr: Thomas Jaki
- Profion cyferbyniad lluosog gyda data hydredol. Cynhadledd Ryngwladol ar Gasgliad ar y pryd, Hannover, yr Almaen. 25 Medi 2013.
- Sefydlu bioequivalence mewn treialon traws-dros-dro AB/BA gan ddefnyddio'r gymhareb o AUCs a amcangyfrifir o ddyluniadau samplu bras. 59fed Biometrisches Kolloquium & DAGStat, Freiburg, Yr Almaen. 19 Mawrth 2013. Llenyddiaeth: Thomas Jaki, Martin J Wolfsegger
- Cymharu bioamrywiaeth drwy brofi detholiad o fynegeion amrywiaeth a ddiffiniwyd gan y defnyddiwr ar yr un pryd. 36ain Cynhadledd Biometrig Ryngwladol, Kobe, Japan. 30 Awst 2012.
- Cymharu bioamrywiaeth drwy brofi detholiad o fynegeion amrywiaeth a ddiffiniwyd gan y defnyddiwr ar yr un pryd. 58fed Biometrisches Kolloquium, Berlin, yr Almaen. 14 Mawrth 2012.
Posteri cynhadledd (dewiswyd)
- Ehangiad dos effeithlon sy'n seiliedig ar fodel ar flaenau eich bysedd: offeryn meddalwedd syml i ddylunio a gwerthuso treialon canser cam I. Cynhadledd Canser NCRI, Lerpwl, y DU. 6 Tachwedd 2017. Cyd-awduron: Fang Wan, Christina Yap, Adrian P Mander, Graham M Wheeler, Sally Clive, Thomas Jaki, Lisa V Hampson.
- Dylunio treialon aml-gam aml-fraich gyda'r pecyn R 'MAMS'. Cynhadledd PSI, Berlin, yr Almaen. 23 Mai 2016. Cyd-awduron: Thomas Jaki, Dominic Magirr.
- Dadansoddiad o ddulliau gyda'r pecyn R 'ANOM'. 62ain Biometrisches Kolloquium & DAGStat, Göttingen, Yr Almaen. 16 Mawrth 2016. Cyd-awdur: Ludwig A Hothorn.
- Casgliad sampl fach ar yr un pryd mewn lleoliadau hydredol gan ddefnyddio cyferbyniadau lluosog. 60fed Biometrisches Kolloquium, Bremen, yr Almaen. 12 Mawrth 2014.
Pwyllgorau ac adolygu
Pwyllgorau goruchwylio allanol
- Aelod Pwyllgor Llywio Treial Annibynnol: NOTACS®, TIP2, INTERACT®, TREADON (ar hyn o bryd); MODIWLAIDD, TIP, PLAN-A, AML18/19/LI1 (yn flaenorol)
- Aelod o'r Pwyllgor Monitro Data Annibynnol / Swyddog o'r Bwrdd Monitro Diogelwch Data: NODWEDDION, TRICEPS, ECRAID-Prime, SABRE, DETECT (ar hyn o bryd); ABC Sepsis, CANTOP-RCT (yn flaenorol)
Pwyllgorau cyllido
- Aelod o'r pwyllgor cyllido ar gyfer MRC-NIHR EME (ers 2022)
- Aelod pwyllgor cyllido cyswllt ar gyfer NIHR HTA (2021-2022)
Dyletswyddau golygyddol
- Golygydd Cyswllt ar gyfer Treialon
- Golygydd Adolygiad ar gyfer Frontiers in Psychology
Adolygu
- Adolygydd ceisiadau grant ar gyfer NIHR (HTA, EME, PHR, HS &DR), MRC (BMC DPFS, Better Methods Better Research), MRC-NIHR (Rhaglen Ymchwil Methodoleg), UKRI (Cymrodoriaeth Arweinwyr y Dyfodol), HCRW (Ysgoloriaeth Iechyd PhD, Llwybr i Bortffolio) yn ogystal ag yn rhyngwladol (DFG - Sefydliad Gwyddoniaeth Almaeneg; NCN - Canolfan Wyddoniaeth Genedlaethol Gwlad Pwyl; ZonMW - Sefydliad yr Iseldiroedd ar gyfer Ymchwil a Datblygu Iechyd)
- adolygydd adroddiad terfynol ar gyfer NIHR (HTA, PHR)
- adolygydd haniaethol ar gyfer Cyfarfod Blynyddol 38ain ESPID 2020, ICTMC 2022
- Adolygydd cynnig llyfr ar gyfer Gwasg Prifysgol Caergrawnt
- adolygydd llawysgrifau ar gyfer cyfnodolion gan gynnwys Statistics in Medicine, Journal of Statistical Software, Biometrical Journal, The American Statistician, Statistical Methods in Medical Research, Statistical Papers, Statistics, Journal of Applied Statistics, Journal of Biopharmaceutical Statistics, Communications in Statistics - Efelychu a Chyfrifiant, Journal of Statistical Computation and Simulation, Journal of Computational and Graphical Statistics, Statistica Neerlandica, Journal of Clinical Epidemioleg, Journal of Open Source Software, Modelau stochastig Cymhwysol mewn Busnes a Diwydiant, BMJ Open, PLOS One, Gwyddoniaeth Agored y Gymdeithas Frenhinol, PeerJ, Treialon, Treialon Clinigol, Treialon Clinigol Cyfoes, Journal of Infection, Frontiers in Neurology, BMJ Nutrition Atal ac Iechyd, Trafusion, Journal of Meddygaeth Glinigol, Adolygiadau Natur Darganfod Cyffuriau, Natur Ymddygiad Dynol, The AAPS Journal, The British Student Doctor Journal, Y Rhyngrwyd yn y Dyfodol, Ymchwil Gwyddoniaeth Amgylcheddol a Llygredd, Gwyddor Rheoli Plâu (gweler fy mhroffil Publons)
Meysydd goruchwyliaeth
Goruchwyliaeth gyfredol
Mr Andreas Markoulidakis
Myfyriwr ymchwil
Dr Tamas Barry
Myfyriwr ymchwil
Prosiectau'r gorffennol
- Cyd-oruchwyliwr William Blake – Cymhwyso technegau casgliadau achosol i amcangyfrif effaith newidynnau ffordd o fyw ar ddifrifoldeb clefyd Huntington (MSc Ymchwil Gweithredol ac Ystadegau Cymhwysol, 2022, gydag Andreas Markoulidakis a Monica Busse)
- Cyd-oruchwyliwr Saif Abbas Chatoo – presgripsiynu gwrthfiotigau mewn cleifion ysbyty gyda COVID-19 fel swyddogaeth o farcwyr llidiol yn nhon 1 yn erbyn ton 2: adolygiad systematig (Meddygaeth Poblogaeth BSc Rhyng-gyfrifedig, 2022, gyda Joanne Euden ac Emma Thomas-Jones)
Arbenigeddau
- Ystadegau
- Ystadegau cymhwysol
- Ymchwil clinigol cymhwysol
- Gofal sy'n seiliedig ar dystiolaeth
- GIG